Academic literature on the topic 'Sodium fluoroacetate'
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Journal articles on the topic "Sodium fluoroacetate"
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Proudfoot, Alex T., Sally M. Bradberry, and J. Allister Vale. "Sodium Fluoroacetate Poisoning." Toxicological Reviews 25, no. 4 (2006): 213–19. http://dx.doi.org/10.2165/00139709-200625040-00002.
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Camboim, Expedito K. A., Michelle Z. Tadra-Sfeir, Emanuel M. de Souza, Fabio de O. Pedrosa, Paulo P. Andrade, Chris S. McSweeney, Franklin Riet-Correa, and Marcia A. Melo. "Defluorination of Sodium Fluoroacetate by Bacteria from Soil and Plants in Brazil." Scientific World Journal 2012 (2012): 1–5. http://dx.doi.org/10.1100/2012/149893.
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The aim of this work was to isolate and identify bacteria able to degrade sodium fluoroacetate from soil and plant samples collected in areas where the fluoroacetate-containing plantsMascagnia rigidaandPalicourea aenofuscaare found. The samples were cultivated in mineral medium added with 20 mmol L−1sodium fluoroacetate. Seven isolates were identified by 16S rRNA gene sequencing asPaenibacillussp. (ECPB01),Burkholderiasp. (ECPB02),Cupriavidussp. (ECPB03),Staphylococcussp. (ECPB04),Ancylobactersp. (ECPB05),Ralstoniasp. (ECPB06), andStenotrophomonassp. (ECPB07). All seven isolates degraded sodium-fluoroacetate-containing in the medium, reaching defluorination rate of fluoride ion of 20 mmol L−1. Six of them are reported for the first time as able to degrade sodium fluoroacetate (SF). In the future, some of these microorganisms can be used to establish in the rumen an engineered bacterial population able to degrade sodium fluoroacetate and protect ruminants from the poisoning by this compound.
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Camboim, Expedito K. A., Arthur P. Almeida, Michelle Z. Tadra-Sfeir, Felício G. Junior, Paulo P. Andrade, Chris S. McSweeney, Marcia A. Melo, and Franklin Riet-Correa. "Isolation and Identification of Sodium Fluoroacetate Degrading Bacteria from Caprine Rumen in Brazil." Scientific World Journal 2012 (2012): 1–6. http://dx.doi.org/10.1100/2012/178254.
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The objective of this paper was to report the isolation of two fluoroacetate degrading bacteria from the rumen of goats. The animals were adult goats, males, crossbred, with rumen fistula, fed with hay, and native pasture. The rumen fluid was obtained through the rumen fistula and immediately was inoculated 100 μL in mineral medium added with 20 mmol L−1sodium fluoroacetate (SF), incubated at 39°C in an orbital shaker.Pseudomonas fluorescens(strain DSM 8341) was used as positive control for fluoroacetate dehalogenase activity. Two isolates were identified by 16S rRNA gene sequencing asPigmentiphaga kullae(ECPB08) andAncylobacter dichloromethanicus(ECPB09). These bacteria degraded sodium fluoroacetate, releasing 20 mmol L−1of fluoride ion after 32 hours of incubation in Brunner medium containing 20 mmol L−1of SF. There are no previous reports of fluoroacetate dehalogenase activity forP. kullaeandA. dichloromethanicus. Control measures to prevent plant intoxication, including use of fences, herbicides, or other methods of eliminating poisonous plants, have been unsuccessful to avoid poisoning by fluoroacetate containing plants in Brazil. In this way,P. kullaeandA. dichloromethanicusmay be used to colonize the rumen of susceptible animals to avoid intoxication by fluoroacetate containing plants.
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King, DR, DR King, LE Twigg, LE Twigg, JL Gardner, and JL Gardner. "Tolerance to Sodium Monofluoroacetate in Dasyurids in Western Australia." Wildlife Research 16, no. 2 (1989): 131. http://dx.doi.org/10.1071/wr9890131.
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The tolerances to sodium fluoroacetate (1080) were estimated for Dasyurus geoffroii (LD*50, ca. 7.5 mg 1080 kg-1), D. hallucatus (ca. 7.5 mg kg-1), Antechinus flavipes (ca. 11.0 mg kg-1) and Phascogale calura (ca. 17.5 mg kg-1) from Western Australia and comparisons were made with D. viverrinus (ca. 1.5 mg kg-1) and A. flavipes (ca. 3.5 mg kg-1) from south-eastern Australia. The species from Western Australia have had evolutionary exposure to naturally occurring fluoroacetate and were more tolerant to the toxin than dasyurids from south-eastern Australia, Presumably, they have acquired this tolerance through feeding on prey which had fed on plants containing fluoroacetate.
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Twigg, Laurie E., Gary R. Martin, Alan F. Eastman, the late Dennis R. King, and Winifred E. Kirkpatrick. "Sensitivity of some Australian animals to sodium fluoroacetate (1080): additional species and populations, and some ecological considerations." Australian Journal of Zoology 51, no. 5 (2003): 515. http://dx.doi.org/10.1071/zo03040.
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The sensitivity to fluoroacetate (1080) of a number of species of rodents and dasyurids with and without evolutionary exposure to fluoroacetate-bearing vegetation was determined. Rattus fuscipes, and species of Pseudomys from populations with exposure to this vegetation, were particularly tolerant to fluoroacetate. However, the level of tolerance varied among the different populations of each species, depending on the degree to which the toxic plants were present in their microhabitat. The tolerance of the F1 offspring of sensitive R. fuscipes (South Australia) crossed with tolerant conspecifics from Western Australia was mid-range between those of the parental populations. The sensitivity of introduced R. rattus and Mus domesticus from areas with fluoroacetate-producing plants in Western Australia was similar to that reported elsewhere for these rodents. This suggests that their relatively short coexistence with the toxic plants has had little obvious impact on their level of sensitivity to fluoroacetate. The dibbler, Parantechinus apicalis, which coexists with the toxic vegetation, was exceptionally tolerant for a native carnivore/insectivore (LD50 ~35 mg 1080 kg–1). In contrast, however, Phascogale tapoatafa from southern Western Australia was more sensitive to 1080 than was expected, with an estimated LD50 of 7 mg 1080 kg–1. Although the level of tolerance to fluoroacetate was seen to vary depending on the level of exposure of each species/population to fluoroacetate-bearing vegetation, our findings provide further evidence of the evolutionary impact that fluoroacetate-producing plants appear to have had on the genetic composition of indigenous Australian fauna.
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Hugghins, Ernest J., Howard H. Casper, and C. David Ward. "Tissue Fluoroacetate Residues in Prairie Dogs Dosed with Low-Level Sodium Monofluoroacetate." Journal of AOAC INTERNATIONAL 71, no. 3 (May 1, 1988): 579–81. http://dx.doi.org/10.1093/jaoac/71.3.579.
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Abstract A total of 83 black-tailed prairie dogs (Cynomys ludovicianus) from South Dakota were subjected to low-level treatment with sodium monofluoroacetate (Compound 1080) in the laboratory (0.01-0.30 mg 1080/kg). The acute oral median lethal dose (LD50) of 1080 administered by oral gavage was established at 0.173 mg/kg. To assay fluoroacetate residues, 8 kinds of tissue from each of 10 prairie dogs dead of low-level 1080 poisoning were analyzed by capillary gas chromatography-mass spectrometry. Of the total of 79 tissues analyzed, 73 contained <100 ppb fluoroacetate, and 67 contained <50 ppb fluoroacetate. To test the effect of secondary poisoning on nontarget species, 8 European ferrets (Mustela furo) were fed ground whole carcasses of prairie dogs dead of low-level 1080 poisoning, with no observable ill effects on the ferrets
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Sherley, M. "Is sodium fluoroacetate (1080) a humane poison?" Animal Welfare 16, no. 4 (November 2007): 449–58. http://dx.doi.org/10.1017/s096272860002738x.
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AbstractSodium fluoroacetate (1080) is widely used for the control of vertebrate pests in Australia. While the ecological impact of 1080 baiting on non-target species has been the subject of ongoing research, the animal welfare implications of this practice have received little attention. Literature relevant to the humaneness of 1080 as a vertebrate pest control agent is reviewed in this paper. Previous authors have largely concentrated on the perception of pain during 1080 toxicosis, giving limited attention to other forms of distress in their assessments. Authors who suggest that 1080 is a humane poison largely base their conclusions on the argument that convulsive seizures seen in the final stages of 1080 toxicosis indicate that affected animals are in an unconscious state and unable to perceive pain. Other authors describe awareness during seizures or periodic lucidity that suggests central nervous system (CNS) disruption cannot be assumed to produce a constant pain-free state. Some literature report that 1080 poisoning in humans is painless and free of distress, but this is contradicted by other clinical studies. Using available data an attempt is made to reassess the humaneness of 1080 using the following criteria: speed and mode of action, appearance and behaviour of affected animals, experiences of human victims, long-term effect on survivors, and welfare risk to non-target animals. It is concluded that sodium fluoroacetate should not be considered a humane poison, and there is an urgent need for research into improving the humaneness of vertebrate control methods in Australia.
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Cowled, Brendan D., Eddie Gifford, Michelle Smith, Linton Staples, and Steven J. Lapidge. "Efficacy of manufactured PIGOUT® baits for localised control of feral pigs in the semi-arid Queensland rangelands." Wildlife Research 33, no. 5 (2006): 427. http://dx.doi.org/10.1071/wr05083.
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Conservative population declines of 73% were recorded in three independent feral pig populations in Welford National Park, Queensland, when PIGOUT® baits containing 72 mg of sodium fluoroacetate were used in a baiting program following prefeeding. Declines were measured using a prebaiting population census with remote cameras, followed by carcass recovery. The knockdown of susceptible feral pigs may have been higher than this, since any carcasses not recovered reduced the recorded efficacy. In addition, feral pigs know to have left the baiting area after trapping and telemetry-tagging, and subsequently not exposed to toxic baits, were included in the analysis. The use of remote cameras and carcass recovery appears to be a relatively accurate means of recording localised declines in feral pig populations. This method is applicable only when carcass recovery is possible, such as in open areas in the semi-arid rangelands. A decline of 86% of radio-tagged feral pigs attending bait stations was also recorded. Camera observations revealed no non-target consumption of baits. Measurement of sodium fluoroacetate–contaminated tissues from feral pigs showed that residues were too low to present a significant risk to recorded scavenging animals in the area. Some feral pigs vomited before death, with vomitus containing sodium fluoroacetate poison at high concentrations. No vomitus was consumed by non-target species. Almost all feral pigs were killed relatively rapidly after ingestion of sodium fluoroacetate and the signs observed in a small number of poisoned feral pigs did not indicate a significant welfare concern.
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Collicchio-Zuanaze, R. C., M. Sakate, D. S. Schwartz, E. Trezza, and A. J. Crocci. "Calcium gluconate and sodium succinate for therapy of sodium fluoroacetate experimental intoxication in cats: clinical and electrocardiographic evaluation." Human & Experimental Toxicology 25, no. 4 (April 2006): 175–82. http://dx.doi.org/10.1191/0960327106ht609oa.
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Sodium fluoroacetate (SFAC) or Compound 1080 is a potent rodenticide, largely used after 1946 for rodent and home pest control. The toxic effects of SFAC are caused by fluorocitrate action, a toxic metabolite, which has a competitive action with aconitase enzyme, leading to citrate accumulation and resulting in interference in energy production by Krebs cycle blockade. In the present study, domestic cats were intoxicated with oral doses of fluoroacetate (0.45 mg/kg). The intoxicated animals presented emesis, diarrhea with abdominal pain posture and an abdominal palpation, tachypnea, bilateral midriasis, hypothermia, hyperexcitability and convulsions. Blood gas analysis indicated decreased pH and bicarbonate levels. Serum ionized calcium was also decreased. ECG showed non–specific changes in ventricular repolarization and ventricular arrhythmias. The survival rate was 75% in the treated group with calcium gluconate and sodium succinate and 37.5% in the nontreated group.
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Parry, Emily, and Stuart A. Willison. "Direct aqueous injection of the fluoroacetate anion in potable water for analysis by liquid chromatography tandem mass-spectrometry." Analytical Methods 10, no. 46 (2018): 5524–31. http://dx.doi.org/10.1039/c8ay02046a.
Full textDissertations / Theses on the topic "Sodium fluoroacetate"
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Morgan, D. R. "Maximising the effectiveness of aerial 1080 control of possums (Trichosurus vulpecula)." Diss., Connect to this title online, 2004. http://theses.lincoln.ac.nz/public/adt-NZLIU20060911.123107/index.html.
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Kirkpatrick, Winifred E. "Assessment of sodium fluoroacetate (1080) in baits and its biodegradation by microorganisms." Thesis, Curtin University, 1999. http://hdl.handle.net/20.500.11937/128.
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In Western Australia dried meat baits containing 1080 are used extensively by agricultural and conservation organisations to control foxes and dingoes for the protection of agricultural production and native fauna. Field trials were conducted to assess 1080 loss from dried meat baits and this required the analysis of over five hundred baits. Because of this large number of baits it was essential to have a simple and efficient 1080 extraction procedure and method of 1080 analysis. In this study three methods of 1080 extraction and the new bioassay method for 1080 analysis were investigated. A simple and cost-effective 1080 extraction method using water with a 98% 1080 recovery rate was developed and modifications to the bioassay method were made.Factory-produced 1080 dried meat baits were laid in the field during different seasons at four locations in Western Australia, samples were collected over time and analysed for 1080 content using the bioassay. Rainfall was recorded and temperature data was collected for each site. Baits were exposed to the elements but were placed in mesh or wire cages to restrict invertebrate attack and prevent removal by vertebrates. Some baits were placed on the surface and others were buried. Initially 1080 loss from baits from all 4 sites was minimal, ranging from 0 - 21% at day 7 - 9. Further loss was gradual even when rainfall was recorded. Generally baits had to be exposed to at least 50 mm of rain before 1080 loss increased to 50%. At some sites baits continued to remain toxic to foxes even after long exposure. The mean 1080 content of baits from the Carnarvon site at day 226 was 2.0 mg (55% of the mean 1080 content of baits at day zero) with 137 mm of rainfall recorded for that period. Loss of 1080 from baits buried occurred at a faster rate than from baits placed on the surface during the same time period. By day 14 no 1080 was detected in the buried baits compared to the 68% detected in the surface baits. Under certain conditions 1080 loss from baits was minimal. Levels of 1080 in baits from Nangeen Hill remained fairly constant during the months of September to December 1995, and again during February to April 1996.Gastrolobium plant tissue and soil samples from the southwest of Western Australia were investigated for the presence of 1080 degrading microorganisms. Microbes were isolated and individually tested in solution containing 1080 as the sole carbon source. Isolates which showed 1080 degrading ability were further tested for their degrading efficiency in McClung carbon-free solution with added 1080 as the sole source of carbon and in factory 1080 waste solution, at 1080 concentrations of 20 and 200 mM. The effect of temperature on their rate of degradation was also examined. Thirteen isolates (7 fungi and 6 bacteria) showing varying degrees of 1080 degrading ability were obtained. Rates of 1080 degradation varied among isolates but were highest in the factory waste solution at the 20 mM concentration and in the McClung solution, where 1080 was the sole source of carbon, at the higher concentration of 200 mM. The most efficient isolates OSK and 10H (both Pseudomonas species) degraded all the 1080 present in sterile factory waste solution up to 20 mM 1080 concentration in 4 days and the isolate 1AF (Fusarium oxysporum) degraded 93% of 200 mM 1080 in the McClung solution in 9 days. The optimum temperatures for 1080 degradation were 30 degrees celsius and fluctuating ambient temperatures of 15 28 degrees celsius.
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Kirkpatrick, Winifred E. "Assessment of sodium fluoroacetate (1080) in baits and its biodegradation by microorganisms." Curtin University of Technology, School of Biomedical Sciences, 1999. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=10174.
Full textAbstract:
In Western Australia dried meat baits containing 1080 are used extensively by agricultural and conservation organisations to control foxes and dingoes for the protection of agricultural production and native fauna. Field trials were conducted to assess 1080 loss from dried meat baits and this required the analysis of over five hundred baits. Because of this large number of baits it was essential to have a simple and efficient 1080 extraction procedure and method of 1080 analysis. In this study three methods of 1080 extraction and the new bioassay method for 1080 analysis were investigated. A simple and cost-effective 1080 extraction method using water with a 98% 1080 recovery rate was developed and modifications to the bioassay method were made.Factory-produced 1080 dried meat baits were laid in the field during different seasons at four locations in Western Australia, samples were collected over time and analysed for 1080 content using the bioassay. Rainfall was recorded and temperature data was collected for each site. Baits were exposed to the elements but were placed in mesh or wire cages to restrict invertebrate attack and prevent removal by vertebrates. Some baits were placed on the surface and others were buried. Initially 1080 loss from baits from all 4 sites was minimal, ranging from 0 - 21% at day 7 - 9. Further loss was gradual even when rainfall was recorded. Generally baits had to be exposed to at least 50 mm of rain before 1080 loss increased to 50%. At some sites baits continued to remain toxic to foxes even after long exposure. The mean 1080 content of baits from the Carnarvon site at day 226 was 2.0 mg (55% of the mean 1080 content of baits at day zero) with 137 mm of rainfall recorded for that period. Loss of 1080 from baits buried occurred at a faster rate than from baits placed on the surface during the same time period. By day 14 no 1080 was ++detected in the buried baits compared to the 68% detected in the surface baits. Under certain conditions 1080 loss from baits was minimal. Levels of 1080 in baits from Nangeen Hill remained fairly constant during the months of September to December 1995, and again during February to April 1996.Gastrolobium plant tissue and soil samples from the southwest of Western Australia were investigated for the presence of 1080 degrading microorganisms. Microbes were isolated and individually tested in solution containing 1080 as the sole carbon source. Isolates which showed 1080 degrading ability were further tested for their degrading efficiency in McClung carbon-free solution with added 1080 as the sole source of carbon and in factory 1080 waste solution, at 1080 concentrations of 20 and 200 mM. The effect of temperature on their rate of degradation was also examined. Thirteen isolates (7 fungi and 6 bacteria) showing varying degrees of 1080 degrading ability were obtained. Rates of 1080 degradation varied among isolates but were highest in the factory waste solution at the 20 mM concentration and in the McClung solution, where 1080 was the sole source of carbon, at the higher concentration of 200 mM. The most efficient isolates OSK and 10H (both Pseudomonas species) degraded all the 1080 present in sterile factory waste solution up to 20 mM 1080 concentration in 4 days and the isolate 1AF (Fusarium oxysporum) degraded 93% of 200 mM 1080 in the McClung solution in 9 days. The optimum temperatures for 1080 degradation were 30 degrees celsius and fluctuating ambient temperatures of 15 28 degrees celsius.
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Peterson, Amanda Jane. "The long-term impacts of an aerial 1080 application on non-target forest species." Thesis, University of Canterbury. Biological Sciences, 2014. http://hdl.handle.net/10092/9700.
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The control of introduced mammalian predators in New Zealand forests is crucial for the protection of native species and essential ecosystem services. Possum control in the form of aerial 1080 applications is conducted by TbFree New Zealand to prevent the spread of bovine tuberculosis, and often has the added conservation benefit of temporarily reducing levels of other mammalian predators such as rodents and mustelids. However, native non-target species such as birds and weta can also be at risk of direct and secondary poisoning following 1080 applications, as well as increased predation risk through mesopredator release. To determine whether the benefits of 1080 applications outweigh the risks to non-target native species, both short and long-term monitoring of populations following aerial 1080 applications is needed.
For this study, two forest regions in the South Island were selected for pre- and post-treatment monitoring of non-target species following an aerial 1080 application for possum control. Each region contained a treatment site and a paired non-treatment site. Relative indicies of possums, rodents and other mammalian predators were obtained using tracking tunnels and chew cards, indicies of birds were obtained using five-minute bird counts, and indicies of tree weta were obtained using tracking tunnels and artificial shelters. Monitoring was conducted before the aerial 1080 was applied in August 2012, and over the following 2012/13 and 2013/14 summer seasons.
The aerial 1080 applications were successful at reducing possums to undetectable levels at both treatment sites for the two seasons following treatment. Mice were significantly reduced at one treatment site relative to the paired non-treatment site immediately following the 1080 operation, but had increased to pre-1080 levels by the second post-treatment monitoring season. Rats were detected at low levels, and showed no response to the treatment. Mustelids were not detected at either region throughout the monitoring period.
No native species showed a decline in a treatment site that was not matched in the non-treatment site. Chaffinches significantly declined at both treatment sites relative to non-treatment sites, likely due to an indirect delayed effect such as competition for food resources. Tomtits showed a positive response to the treatment, significantly increasing in both treatment sites over the post-treatment monitoring periods. Tree weta showed no significant decline in response to the treatment. The reduction of possums to low levels, and the maintenance of possum control with ongoing 1080 operations, is likely to continue to provide an overall net benefit to native non-target species.
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Cunha, Luciana Castro da. "Avaliação dos efeitos tóxicos da Mascagnia rigida em ratos. Estudo anatomopatológico. Comparação entre metodologias cromatográficas para detecção do fluoroacetato de sódio." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-28052008-100702/.
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O fluoroacetato de sódio (FAS), também conhecido como \"composto 1080\", foi um raticida amplamente utilizado no combate de roedores a partir da década de 40, mas que teve seu uso proibido em diversos países, incluindo o Brasil, devido a sua alta toxicidade e ausência de tratamento efetivo nas intoxicações. A despeito deste fato, diversos casos de intoxicação ainda são registrados em seres humanos e animais, em virtude de seu uso ilícito como raticida doméstico ou adição em iscas nas intoxicações criminosas. O FAS, na natureza, pode ser encontrado, também, em algumas plantas tóxicas de grande importância no Brasil, como a Palicourea marcgravii, e possivelmente seja o princípio ativo tóxico de outras plantas de relevância, como a Mascagnia rigida. Neste sentido, este trabalho objetivou o estudo dos aspectos clínicos e anatomopatológicos encontrados nas intoxicações provocadas pelo FAS, em ratos, comparando estes com os encontrados nas intoxicações por extrato aquoso da M. rígida. Também foram comparadas metodologias analíticas para identificação deste agente tóxico utilizando cromatografia em camada delgada (CCD) e cromatografia de alta eficiência (CLAE) com dois tipos de detectores o de UV e o de Condutividade Iônica. Para tanto, quatro grupos contendo seis ratos Wistar, machos, receberam em dose única por via oral 7,0 mg/kg de FAS ou água destilada ou ainda 1,6 ou 3,2 g/kg de extrato aquoso de M. rígida, sendo avaliados os sinais clínicos apresentados por estes animais. Após eutanásia foram coletados fragmentos de cérebro, coração, fígado, rins, pulmão, intestino e baço para exame histopatológico. Tanto os animais que receberam FAS como os que receberam extrato aquoso de M. rígida apresentaram sintomatologia similar com presença de prostração, desconforto respiratório, tremores, pêlos arrepiados, cromodacriorreia, convulsão tônica e tônico-clônica. Na necropsia destes animais não foram observadas alterações macroscópicas, contudo alterações histopatológicas significativas foram encontradas no cérebro, miocárdio, fígado e rins. Os estudos das análise toxicológicas utilizando as três técnicas cromatográficas mostraram que os resultados obtidos na CCD foram adequados para detecção de FAS nas concentrações acima de 1,0 μg do padrão puro e as análises das duas plantas estudadas apresentaram resultados positivos para FAS. As técnicas utilizando CLAE, com dois diferentes detectores, mostraram que quando se utiliza detector de UV o limite de detecção é de 3,75 μg injetado ou de 75 μg/mL e foi possível, também, detectar a presença de FAS nas duas plantas estudadas, porém a técnica não se apresentou adequada para a detecção de intoxicação em tecido animal. O detector de condutividade iônica mostrou limite de detecção de 0,30 μg/mL, isto é, o mais sensível entre os três métodos estudados, e portanto o mais adequado para diagnóstico de intoxicação em tecido animal; no entanto, para identificação do FAS na M. rigida este método não se mostrou adequado devido a interferentes no extrato aquoso e no soro de animais intoxicados.Sodium fluoroacetate (SFA), also known as \"compound 1080,\" was a rodenticide widely used in the 1940s, but its use was banned in several countries, including Brazil, for its high toxicity and lack of an effective treatment in poisoning. Despite this fact, several cases of poisoning are still registered in humans and animals, because of their misuse as baits, in addition to criminal poisoning. SFA, in the form of natural molecules, can be found in some toxic plants of great importance in Brazil, such as Palicourea marcgravii, and possibly is the active principle of other plants of relevance, such as Mascagnia rigid. Therefore, this study aimed to evaluate the clinical and pathological findings in poisoning caused by the SFA in rats, and compare them with those found in poisoning by the aqueous extract of M. rigid. Moreover, we compared analytical methods for identifying this toxic agent using thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) employing two types of detectors: ultraviolet (UV) and ionic conductivity. Therefore, four groups containing six male Wistar rats each, received a single oral dose of 7.0 mg / kg of SFA, an equal volume of distilled water, or 1.6 or 3.2 g / kg of an aqueous extract of M. rigid, and the clinical signs displayed by these animals were evaluated. After euthanasia fragments of brain, heart, liver, kidney, lung, intestine and spleen were collected for histological examination. Both the animals that received SFA and those who received the aqueous extract of M. rigid showed similar symptoms, including prostration, respiratory distress, tremors, shivering, and tonic or tonic-clonic seizures. At necropsy, these animals did not display macroscopic changes. Nevertheless, significant histopathological changes were found in the brain, heart, liver and kidneys. Toxicological analysis using the three chromatographic techniques described above showed that the results obtained in the TLC were suitable for detection of SFA at concentrations above 1.0 μg of pure standard, and analysis of the two plants mentioned showed positive results for SFA. The techniques using HPLC with two different detectors showed that when using the UV detector, the detection limit is of 3.75 μg (injected) or 75 μg / mL, and SFA could also be detected by these methods in the two plants studied, but the technique does not seem suitable for the detection of intoxication in animal tissue samples. The ionic conductivity detector showed a detection limit of 0.30 μg/ mL, therefore the most sensitive of the three methods studied, and hence is the most appropriate for diagnosis of poisoning in animal tissue; however, for the identification of SFA in the M. rigid, this method was not appropriate due to a putative interference in the aqueous extract.
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Foronda, Natalia, and n/a. "Health risk assessment and health risk management with special reference to sodium monofluoroacetate (1080) for Possum control in New Zealand." University of Otago. Department of Pharmacology & Toxicology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20080131.145423.
Full textAbstract:
The principal use of sodium monofluoroacetate (1080) in New Zealand is to control brushtail possums (Trichosurus vulpecula). Aerial application of baits containing 1080 is the most common method used for large-scale control of possums.
The use of 1080 attracts a great deal of controversy, in particular the effects on the environmental, non-target species, and the potential chronic effects in humans associated with environmental exposures. Although the nature of the acute toxicity of 1080 has been known for more than fifty years, little is known of its effects on humans, in particular its chronic effects to environmental exposures.
A benchmark dose (BMD) as an alternative to a no-observed-adverse-effect-level (NOAEL) approach was investigated as a means to improve current health risk assessment values of 1080. Both approaches were investigated for three critical toxicological end points, namely cardiomyopathy, testicular toxicity and teratogenic effects identified from the few available critical studies. The calculated BMDs and lower-bound confidence limits (BMDLs) for the three end points were estimated using the Weibull, probit and quanntal linear models. A benchmark response (BMR) of 10% (extra risk) was chosen and the Akaike�s information criterion (AIC) was used in selecting the appropriate model. The BMDL estimates derived were generally slightly higher but comparable to the corresponding NOAEL for those same endpoints. The computed BMD₁₀ and BMDL₁₀ for cardiomyopathy and testicular effects were 0.21 mg kg⁻�bw⁻� and 0.10 mg kg⁻�bw⁻�, respectively. Tolerable Daily Intakes (TDIs) were derived using the NOAEL approach and the BMD methodology and applying an uncertainty factor of 3000. The resulting TDI using the BMDL were generally consistently slightly higher than those derived using the NOAEL approach. Based on the best fit of modelled dose-response data, a TDI of 0.03 [mu]g kg⁻�bw⁻�day⁻� is proposed for human health risk assessment.
Two sets of Provisional Maximum Acceptable Values (PMAV) were derived using the highest concentration of 4.0 [mu]g L⁻� 1080 found in water (N=1450), and using the maximum allowable concentration of 2.0 [mu]g L⁻� of 1080 in water for adults (0.58 [mu]g L⁻� and 0.94 [mu]g L⁻�, respectively) and children (0.23 [mu]g L⁻� and 0.4 [mu]g L⁻�, respectively). Parameters used in the derivation of PMAVs were average weight, average quantity of water consumed, and proportion of total intake allocated to drinking water. The derived adult PMAV of 0.60 [mu]g L⁻� is proposed in revising the PMAV for 1080 in the Drinking Water Standards New Zealand. This value is 6-fold lower than the current PMAV of 3.5 [mu]g L⁻�. Additional toxicology studies are recommended to meet the definition of a "complete database" and therefore estimating a more defensible TDI, and consequently a PMAV for 1080.
Risk management approaches are consistent with the Ministry of Health�s current precautionary approach. A PMAV of 0.60 [mu]gL⁻� in drinking water is recommended to consider it suitable for human consumption and that continuous monitoring be carried if the level of 1080 exceeds 50% of the proposed PMAV as a requirement for Priority 2 determinands in the Drinking Water Standards. Precautionary approach appears to be warranted and this was supported by information provided by the Public Health Units (PHU) where 1080 was permitted to be dropped onto drinking water catchments. The PHUs exercised precautionary measures by imposing appropriate conditions to suit local circumstances. As 1080 may likely remain an essential tool to contain tuberculosis spread by possums and to reduce possum damage to forests and crops until better methods of control are developed, a number of recommendations were proposed to protect public health.
Books on the topic "Sodium fluoroacetate"
1
Warburton, B. Comparison of three methods for maintaining possums at low density. Wellington, N.Z: Dept. of Conservation, 2002.
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2
Veltman, C. J. The potential of poisoned foliage as bait for controlling feral goats (Capra hircus). Wellington, N.Z: Dept. of Conservation, 2002.
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3
Eisler, Ronald. Sodium monofluoroacetate (1080) hazards to fish, wildlife, and invertebrates: A synoptic review. Washington, D.C: U.S. Dept. of the Interior, National Biological Service, 1995.
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4
Eisler, Ronald. Sodium monofluoroacetate (1080) hazards to fish, wildlife, and invertebrates: A synoptic review. Washington, D.C: U.S. Dept. of the Interior, National Biological Service, 1995.
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5
Benfield, W. F. At war with nature: Corporate conservation and the industry of extinction. Wellington, New Zealand: Tross Publishing, 2015.
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6
Towns, D. R. Restoration plan for Korapuki Island (Mercury Islands), New Zealand, 2004-2024 / David R.Towns and Ian A.E. Atkinson. Wellington, N.Z: Dept. of Conservation, 2004.
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7
Sodium monofluoroacetate (1080) hazards to fish, wildlife, and invertebrates: A synoptic review. Washington, D.C: U.S. Dept. of the Interior, National Biological Service, 1995.
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8
Wilson, Carla, and D. R. Towns. Community Consultation Processes for Aerial 1080 Applications (Science for Conservation,). Department of Conservation, 2004.
Find full textBook chapters on the topic "Sodium fluoroacetate"
1
Gooch, Jan W. "Sodium Fluoroacetate." In Encyclopedic Dictionary of Polymers, 674. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_10830.
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2
Hallenbeck, William H., and Kathleen M. Cunningham-Burns. "Sodium Fluoroacetate." In Pesticides and Human Health, 125. New York, NY: Springer New York, 1985. http://dx.doi.org/10.1007/978-1-4612-5054-8_85.
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3
Wallace, David R. "Sodium Fluoroacetate." In Encyclopedia of Toxicology, 62–64. Elsevier, 2005. http://dx.doi.org/10.1016/b0-12-369400-0/00889-9.
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"Sodium fluoroacetate." In Encyclopedic Dictionary of Polymers, 898. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-30160-0_10634.
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5
Wallace, D. R. "Sodium Fluoroacetate." In Encyclopedia of Toxicology, 331–33. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-386454-3.00196-2.
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