Dissertations / Theses on the topic 'SMCR8'
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1
Pietri, David. "Structure and function of the C9ORF72-SMCR8-WDR41 complex and its implication for Amyotrophic Lateral Sclerosis (ALS)." Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAJ087.
Abstract:
La sclérose latérale amyotrophique (SLA ou maladie de Charcot) est la troisième maladie neurodégénérative la plus répandue. La principale cause génétique de la SLA est une expansion de répétitions GGGGCC dans le gène C9ORF72, dont la protéine forme un complexe avec les protéines SMCR8 et WDR41. Afin de mieux comprendre ses fonctions moléculaires, résoudre sa structure était un objectif principal de ma thèse. En parallèle, nous avons découvert que C9ORF72 régule un mécanisme nouvellement décrit de biogenèse de nouveaux lysosomes nommé reformation autophagique des lysosomes (ALR). Ce processus a largement été investigué dans cette thèse afin de mieux comprendre sa régulation, notamment pour la régénération des lysosomes en conditions basales et de privation d’acides aminés. Mon travail révèle un nouveau partenaire du complexe C9ORF72 et une nouvelle fonction de ce complexe dans la biogenèse des lysosomes. Ces résultats pourraient ainsi expliquer le dysfonctionnement des lysosomes et la neurodégénérescence observés dans la SLA, ce qui pourrait ainsi ouvrir de nouvelles voies thérapeutiques pour cette maladie dévastatriceAmyotrophic lateral sclerosis (ALS or Charcot disease) is the third most common neurodegenerative disease. The main genetic cause of ALS is an expansion of GGGGCC repeats in the C9ORF72 gene which protein forms a complex with the SMCR8 and WDR41 proteins. To better understand its molecular functions, solving its structure was a main goal of my thesis. In parallel, we discovered that C9ORF72 regulates a newly described mechanism of biogenesis of newly-formed lysosomes, called autophagic lysosome reformation (ALR). This process has been extensively investigated during my thesis, in order to better understand its regulation, particularly for the regeneration of lysosomes in basal conditions and amino acid deprivation. My work reveals a new partner of the C9ORF72 complex as a novel function in lysosome biogenesis. These results could thus explain the dysfunction of lysosomes and neurodegeneration observed in ALS, which open new therapeutic ways for this devastating disease
2
O'Donohue, Daniel J. "First-term retention of enlisted Selected Marine Corps (SMCR) Reservists." Thesis, Monterey, California. Naval Postgraduate School, 1988. http://hdl.handle.net/10945/23233.
Abstract:
This thesis examines factors that influence a male, first-term enlisted reservist's decision to remain in the Selected Marine Corps Reserve (SMCR). Specifically, the logistic regression model was used to determine the relative impact of bio-demographic and both pecuniary and nonpecuniary job factors on retention. Models were developed for both nonprior (NPS) and prior active service (PS) reservists. The database was a combination of the responses of participants in the 1986 Reserve Components Surveys and their personnel records from the Reserve Components Common Personnel Data System. The thesis concludes with reserve policy implications and recommendations for further research. Important findings of this thesis were: Reserve income has a statistically significant and positive impact on SMCR retention. Civilian income was not found to be a factor. Educational benefits, civilian job-related training, and retirement benefits were found to be significant factors in retaining prior service reservists. Keywords: Marine corps personnel, Job training, Personnel retention, Theses
3
Licari, Anthony D. "DEVELOPING A MARKOV MODEL FOR FORECASTING END STRENGTH OF SELECTED MARINE CORPS RESERVE (SMCR) OFFICERS." Monterey, California. Naval Postgraduate School, 2013. http://hdl.handle.net/10945/32856.
Abstract:
This thesis develops Markov models for prior service (PS) and non-prior service (NPS) Selected Marine Corps Reserve (SMCR) officers. Data were collected from the Total Force Data Warehouse (TFDW) for all SMCR officers who served between September 30, 1998 and October 31, 2012. Determining SMCR officer end strength is necessary for reserve manpower planners to balance the force structure, minimize personnel excesses and shortages that impact training and labor costs, and to manage career progression. The PS model validation and analysis show that an aggregate monthly rate and unique monthly transition rates produce similar results. Both models perform well and they are consistent and accurate. Consistency and accuracy are important because budget planners and recruiting command rely on manpower estimates during the fiscal year. Overall, the aggregate monthly rate models perform slightly better than the unique monthly transition rate models with respect to end strength prediction, average strength prediction, and cost. More importantly, all four PS models performed better than the current Reserve Affairs model. We are unable to validate the NPS officer model. Since there are so few observations, the transition rates are suspect because they have a very high variance.
4
Conley, Gary D. "Examining the Cover and Composition of the Successional Vegetation Mosaic of Pre-SMCRA Mined Landscapes in Southeast Ohio." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1357751096.
5
Holsinger, John Frederick. "The Impact of SMCRA on Select Soil Properties in Reclaimed Mine Sites Determined by Geochemical and Hydrological Analyses." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1406134738.
6
Leveroos, Maura K. "Economic Viability of Woody Bioenergy Cropping for Surface Mine Reclamation." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/50950.
Abstract:
Planting woody biomass for energy production can be used as a mine reclamation procedure to satisfy the Surface Mining Control and Reclamation Act of 1977 (SMCRA) and provide renewable energy for the United States. This study examines the economic viability of bioenergy production on previously mined lands using multiple hardwood species and treatments. Five species were planted at two densities; one-half of the trees were fertilized in year two. Height and diameter of the trees were measured annually for five years; the first three years by cooperating researchers at Virginia Tech, the last two years specifically for this report. Current and predicted mass of the species, effects of planting density and fertilizer application, and the land expectation value (LEV) of each treatment were summarized. A sensitivity analysis was conducted to determine how changes in production costs, stumpage price, rotation length, and interest rate affect the economic feasibility of bioenergy production. Renewable energy and mine reclamation policies were investigated and it was determined that woody bioenergy can be planted as a mine reclamation procedure and may receive financial incentives. Production cost appears to have the largest impact on LEV and is often the difference between positive and negative returns for the landowner. The extra cost of fertilization and high density planting do not increase LEV; the unfertilized, low density treatments have the best LEV in all examined scenarios. In general, bioenergy was found to be economically viable as a mine reclamation procedure only in limited circumstances. In low cost, high price scenarios, bioenergy crops could have the potential to reforest both active and abandoned mine lands throughout southern Appalachia.Master of Science
7
Prichard, Elizabeth Dulaney. "Sustainable Community Development in Boom and Bust Economies: A Comparative Case Analysis of Institutional Stakeholder Interaction in Four Appalachian Natural Resource Dependent Locales." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/99286.
Abstract:
The purpose of this dissertation research is to examine how local context in four natural resource dependent Appalachian settings shape the formal Basic Engagement Plan (BEP). In 2002, the federal Office of Surface Mining, Reclamation and Enforcement (OSMRE) formed a partnership with AmeriCorps VISTA and local environmental improvement organizations to restore Appalachian locales suffering from pre-regulatory environmental damage. To stimulate diverse local institutional engagement, the partnership developed the BEP. It is a formal process of institutional interaction to initiate working relationships where none exist between participating organizations and public administrators, legislators, and nonprofit organizations. To explore the research question, I use a multiple-case study design and comparative analysis. Because the partners work to restore local environments through sustainable community development, the research is grounded in sustainable community development literature. I continue the trend that juxtaposes its considerations of environmental protection, economic development, and social justice with the interactional perspective of community, a sociological model of community grounded in social interaction. Sustainable community development literature is dominated by an authoritative intervention paradigm. The juxtaposed model at the heart of this research does not deny the important contributions of authoritative intervention. Rather, it complements this conventional arrangement by discussing the important role of horizontal institutions in the process. Key findings show local contexts are multi-faceted and dynamic. In this regard, the variation in impact of local contexts on the formal BEP process shows that a one-size-fits-all approach is problematic for sustainable community development in natural resource dependent settings. The dissertation concludes with a set of comparative findings across the four cases and discussion of four important ways in which the research contributes to theory and practice.PHD
8
Erhardt, Bruce J. Jr. "Development of a Markov Model for Forecasting Continuation Rates for Enlisted Prior Service and Non-Prior Service Personnel in the Selective Marine Corps Reserve (SMCR)." Thesis, Monterey, California. Naval Postgraduate School, 2012. http://hdl.handle.net/10945/6791.
Abstract:
The purpose of this thesis is to develop a Markov model to determine the continuation rates for Prior Service and Non-Prior Service enlisted population in the Selected Marine Corps Reserve (SMCR). Determining the end strength for these populations is necessary for reserve manpower planners to balance the force structure to minimize personnel overage or underages that impact training and labor costs, as well as career progression. The results of model validation indicate that models based on annual aggregate monthly transition rates fails the stationarity assumption required of Markov models. These results suggest that the attrition behaviors are seasonal for both enlisted populations leading to numerous states being non stationary in part due to their correlation with seasonality. We recommend developing and employing models with unique transition rates for each month.
9
Pennington, Michael Sean. "Is the coal industry worth protecting? an examination of the effects of competing advocacy coalitions on implementation of the Surface Mining Control and Reclamation Act (SMCRA) of 1977." Texas A&M University, 2008. http://hdl.handle.net/1969.1/85961.
Abstract:
Harold Lasswell (1936) defined politics as the exploration of "who gets what,
when, and how." As such, one of the central concerns of democratic governance is the
role that affected interests play not only in politics, but in the implementation of adopted
policies as well. In this dissertation, I use both comparative method case studies, as well
as pooled-time series statistical techniques, to examine the effects of political, economic
and market forces, and competition between the affected interests on implementation of
the Surface Mining Control and Reclamation Act of 1977. The findings of this, as well
as previous, research shows that state-level implementing agencies have some discretion
in enforcement activities; however, closer examination shows that this discretion is
rarely used. This lack of use of regulatory discretion by the state-level implementing
agencies suggests that in most states, there is either sufficient competition between the
affected interests to neutralize the excessive use of discretion in enforcement activity, or
that there is insufficient pressure placed on the implementing agencies by the affected
interests to warrant the use of discretion.
10
Pollock, Matthew John. "Geomorphic Differences between Unmined and Surface Mined Lands in Southeastern Ohio." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429613137.
11
Ruhm, Catherine Terese. "The Effects of Two Types of Reclamation on Abandoned Non-Coal Surface Mines in Cuyahoga Valley National Park, Ohio." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1543876471411951.
12
Back, Michael Patrick. "Working Backwards: Enhancing Forest Restoration by Reversing Effects of Surface Mine Reclamation on Soil Bulk Density and Soil Chemistry." Kent State University Honors College / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors162014875138985.
13
Jonsson, Peder. "Kommunikationsmodeller inom public relations." Doctoral thesis, KTH, Industriell ekonomi och organisation (Inst.), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-205887.
Abstract:
Once a year for over forty years public relations’ practitioners in Sweden gathers, the political week in Almedalen, in the town of Visby. There they exchange knowledge and experience on all types of subjects using different and common communication models whether they are aware of them or not. The research on communication models is sparse, with one exception: Grunig’s model. Both practitioners and researches believe them to be important, even strategic. But too little knowledge about the models as such negatively impacts the understanding of public relations’ activities. It also contributes to the view that public relations is frittered. The thesis studies and analyses communication models of public relations. Models have been created by theorists and practitioners to describe the phenomenon, to understand communication as such and to facilitate communication between humans. The thesis addresses basic questions such as which models there are, where they stem from, who the originators were and the characteristics of each respective model. The basis of the study is comprehensive Anglo-American literature. All in all, over twenty different models have been analyzed in three different ways, i.e. the structure of a model, its historical deposits (sediment) and the application of the model. The result is manifold, since many characteristics form ten attributes and three families of models (a reduction). The characteristics can be seen as the models’ building blocks, e.g. the direction of the communication, the number of contacts and synchronism. Three model families are built on three differentiating characteristics, and the families are named correspondingly. Directional model (Riktningsmodellen), the Co-orientational model (Saminriktningsmodellen) and the Connectivity model (Konnektivitetsmodellen). The classification is of course not set in stone. It should be regarded as a first step to reduce the number of models in use and concentrate on the important characteristics of the models that help public relations researchers and professionals to solve problems and theorists to explain, foresee or guide to better public relations. Finally, five areas of future research are presented: a multinational study of models, a study of practitioners’ model use, a deeper history study according the concept of sediment, a notational system for models and, last but not least, a development of the Connectivity model. The last subject is the one that once inspired me to write a thesis.QC 20170426
14
Gumbel, John D. "An evaluation of the Selected Reserve Educational Assistance Program (SREAP) as it relates to the Selected Marine Corps Reserve (SMCR)." Thesis, 1987. http://hdl.handle.net/10945/22788.
15
Chang, Lih-Yun, and 張力云. "Involvement of an inverted repeats in promoter of Vibrio vulnificus protease gene, vvp, in binding with SmcR and vvp expression." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/40070838247791346840.
Abstract:
碩士國立成功大學
微生物暨免疫學研究所
93
Abstract We have found previously that SmcR, a transcriptional activator, is involved in the regulation of the metalloprotease (vvp) and cytolysin genes in Vibrio vulnificus, a marine bacterium causing wound infections and fatal septicemia. The putative SmcR-binding site in the vvp promoter region has been identified by DNase I footprint analysis, in which an inverted repeat sequence with a spacer of 14 bp was found. To determine the involvement of this inverted repeat region in binding with SmcR and transcriptional activation of vvp, seven point mutations at different positions in this region were created. The promoter mutations together with a downstream lacZ gene (Pvvp-lacZ) that served as the reporter were cloned individually into a suicide plasmid and subsequently introduced into V. vulnificus chromosome via homologous recombination between the lacZ gene in the plasmid and that in the chromosome. By assaying the -galactosidase activity in these strains, we found that four mutations that were located in the inverted repeats resulted in significant decreases in vvp promoter activity. However, another mutation in the inverted repeat and two mutations in the spacer did not affect the vvp promoter activity. We further examined the binding of SmcR to vvp promoter with the various mutations in this region by electrophoresis motive shift assay (EMSA). There was little difference between the wild type vvp promoter and the mutated ones, even those showing reduced vvp promoter activity, in binding with SmcR. One explanation for this inconsistency is that other factors may be involved in binding with vvp promoter region and regulation of vvp expression. On the other hand, the amino acid sequence from residues 39 to 59 of SmcR showed significant homology to the helix turn helix (HTH) DNA-binding domains of LuxR family. To determine the role of this putative HTH domain in binding with vvp promoter, five SmcR mutants were generated. Surprisingly, when expressed from a plasmid in the strain with a Pvvp-lacZ fusion, SmcR devoid of the HTH domain, namely, SmcR63-205 and SmcR101-205, retained the ability to activate the vvp promoter. On the contrary, those containing the HTH domain, SmcR29-205 and SmcR1-99, did not activate the vvp promoter. Furthermore, when combined with the various vvp promoter mutations, the -galactosidase expression patterns of SmcR63-205 were similar to those of the intact SmcR. However, for some reason not clear at this moment, the -galactosidase expression levels of the various vvp promoter mutants were similar to one another in the presence of SmcR101-205. We further examined the binding of SmcR63-205 to the vvp promoter with the various mutations by EMSA, and found that just like the intact SmcR, it bound to all the mutated promoter sequences. These results suggest that the SmcR C-terminal domain may be more important than the HTH domain for binding with and activation of vvp promoter.
16
Wu, Sin-Syuan, and 吳昕玹. "Studies on the Effect of Capsular Polysaccharides on Formation of Biofilm and Expression of Quorum-sensing Regulators LuxR/SmcR in Vibrio vulnificus." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/21810891370752940076.
Abstract:
碩士輔英科技大學
醫學檢驗生物技術系碩士班
101
Vibrio vulnificus is a halophilic gram-negative bacterial species. In nature, V. vulnificus is present in marine environment and causes opportunistic infections in humans including septicemia and wound infection. The capsular polysaccharide is one of potential virulence factors and associated with formation of biofilm. To understand the effect of capsular polysaccharide on the formation of biofilm, this study uses the acapsular strain JF046 (ΔORFVV0364) with a mutation in capsular polysaccharide surface factor. The characteristics of bacterial growth and formation of biofilm were analyzed between strains. Furthermore, the mRNA expression of quorum-sensing regulators including LuxR and SmcR were determined and compared. First, the colony of YJ016 appeared to be opaque and JF046 was translucent. Second, the results of growth curve indicated that the bacterial density for growth (A600) were lower in JF046 than those in YJ016 both in seawater environment (cultured for 24 hours, 1.795 for YJ016, 1.486 for JF046; p=0.006) and fresh water environment (cultured for 24 hours, 1.519 for YJ016, 1.141 for JF046; p=0.005), respectively. Third, the bacterial aggregates were existed in JF046 and absent in YJ016. Fourth, the ability for formations of biofilm (A492/A620) in acapsular mutant JF046 were higher than those in wild type YJ016 both in seawater environment (0.91±0.15 for YJ016, 1.50±0.23 for JF046; p=0.047) and fresh water (0.50±0.05 for YJ016, 1.26±0.20 for JF046; p=0.013). Fifth, the expressions of quorum-sensing regulators, LuxR and SmcR, were compared between JF046 and YJ016. The results form regression analysis revealed that the correlation between mRNA expressions of LuxR and SmcR were r2=0.885 (y=1.045x+7.798) in YJ016 and r2=0.798 (y=0.928x+25.835) in JF046, respectively. In conclusion, the results demonstrated that the ORFVV0364 for capsular polysaccharide surface factor of Vibrio vulnificus is associated with formation of biofilm and quorum-sensing regulators expression.