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Relevant bibliographies by topics / Small molecule-radio conjugates

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Journal articles
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Academic literature on the topic 'Small molecule-radio conjugates'

Author: Grafiati

Published: 14 March 2023

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Journal articles on the topic "Small molecule-radio conjugates"

1

Cazzamalli, Samuele, Andrea Galbiati, Aureliano Zana, et al. "Abstract LB527: A novel dimeric small molecule-radio conjugate targeting fibroblast activation protein with high and prolonged tumor uptake." Cancer Research 82, no. 12_Supplement (2022): LB527. http://dx.doi.org/10.1158/1538-7445.am2022-lb527.

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Abstract Imaging procedures based on small molecule-radio conjugates targeting Fibroblast Activation Protein (FAP) are taking the spotlight in clinical practice for the diagnosis of a wide variety of cancer lesions. However, therapeutic applications of FAP-targeting radioligand therapeutics are limited by their short residence time in tumor lesions. We have recently described the discovery of OncoFAP, a novel ultra-high affinity ligand of FAP which has been already validated for PET imaging applications in more than twenty patients with solid tumors. In this abstract, we describe the developme

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2

Vainshtein, Inna, Scott Silveria, Poonam Kaul, Riaz Rouhani, Richard M. Eglen, and John Wang. "A High-Throughput, Nonisotopic, Competitive Binding Assay for Kinases Using Nonselective Inhibitor Probes (ED-NSIP™)." Journal of Biomolecular Screening 7, no. 6 (2002): 507–14. http://dx.doi.org/10.1177/1087057102238624.

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A novel competitive binding assay for protein kinase inhibitors has been developed for high-throughput screening (HTS). Unlike functional kinase assays, which are based on detection of substrate phosphorylation by the enzyme, this novel method directly measures the binding potency of compounds to the kinase ATP binding site through competition with a conjugated binding probe. The binding interaction is coupled to a signal amplification system based on complementation of β-galactosidase enzyme fragments, a homogeneous, nonisotopic assay technology platform developed by DiscoveRx Corp. In the pr

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3

Lakhanpal, Tamanna, Jaya Shukla, Rajender Kumar, et al. "Abstract A10: Radiolabelled AMD3100 for the management of malignant lymphoma: Translational study." Blood Cancer Discovery 3, no. 5_Supplement (2022): A10. http://dx.doi.org/10.1158/2643-3249.lymphoma22-a10.

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Abstract Introduction: Malignant lymphomas are heterogeneous group of neoplasm comprising of proliferating lymphoid cells or their precursors. The two main types of lymphoma are Hodgkin Lymphoma and Non- Hodgkin Lymphoma. The current treatment modalities include chemotherapy; radiation therapy; passive immunotherapy; radio-immunotherapy and small-molecule inhibitors. Radiation therapy is the treatment of choice if disease is localized. Targeted therapy with antibody and small molecules may be more suitable for malignant lymphomas. Lymphoma cells are reported to over-express chemokine receptors

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4

Galbiati, Andrea, Aureliano Zana, Matilde Bocci, et al. "A novel dimeric FAP-targeting small molecule-radio conjugate with high and prolonged tumour uptake." Journal of Nuclear Medicine, May 19, 2022, jnumed.122.264036. http://dx.doi.org/10.2967/jnumed.122.264036.

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Dissertations / Theses on the topic "Small molecule-radio conjugates"

1

Millul, Jacopo. "Drug Conjugates Specific to Fibroblast Activation Protein and Carbonic Anhydrase IX for Applications in Oncology." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1193822.

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Despite the different therapeutic options available, more than 10 million deaths every year are caused by cancer, thus representing one of the majors’ causes of death worldwide. Lung cancer (1.8 million), breast cancer (700’000), colorectal cancer (950’000), and liver cancer (830’000) represent half of the global cancer incidence. Common approaches for the treatment of cancer include surgery, radiotherapy (external beam radiation and Radioligand Therapy, RLT), chemotherapy and immunotherapy. While radiotherapy indistinctively targets all cells within the tumor environment, chemotherapeutic

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