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Journal articles on the topic 'Small Immunology'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 January 2023

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1

Chong, S. K. F., and J. A. Walker-Smith. "Immunology of small bowel disease." Journal of the Royal Society of Medicine 80, no. 10 (October 1987): 656–59. http://dx.doi.org/10.1177/014107688708001023.

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2

Bland, P. W., and M. Bailey. "Immunology of the small intestine." Transplantation Proceedings 30, no. 6 (September 1998): 2560–61. http://dx.doi.org/10.1016/s0041-1345(98)00725-8.

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3

Kumar, P. J. "Small intestinal immunology and coeliac disease." Current Opinion in Gastroenterology 6, no. 2 (April 1990): 280–87. http://dx.doi.org/10.1097/00001574-199004000-00018.

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4

Allenspach, Karin. "Clinical Immunology and Immunopathology of the Canine and Feline Intestine." Veterinary Clinics of North America: Small Animal Practice 41, no. 2 (March 2011): 345–60. http://dx.doi.org/10.1016/j.cvsm.2011.01.004.

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5

Li, Jindian, Juno Van Valkenburgh, Xingfang Hong, Peter S. Conti, Xianzhong Zhang, and Kai Chen. "Small molecules as theranostic agents in cancer immunology." Theranostics 9, no. 25 (2019): 7849–71. http://dx.doi.org/10.7150/thno.37218.

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6

Kennedy, Melissa A. "A Brief Review of the Basics of Immunology: The Innate and Adaptive Response." Veterinary Clinics of North America: Small Animal Practice 40, no. 3 (May 2010): 369–79. http://dx.doi.org/10.1016/j.cvsm.2010.01.003.

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7

Sarnacki, Sabine, and Nadine Cerf-Bensussan. "Immunologic aspects of small bowel transplantation." Current Opinion in Organ Transplantation 4, no. 4 (December 1999): 343. http://dx.doi.org/10.1097/00075200-199912000-00008.

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8

Berger, M., A. Zeevi, D. G. Farmer, and K. M. Abu-Elmagd. "Immunologic Challenges in Small Bowel Transplantation." American Journal of Transplantation 12 (November 26, 2012): S2—S8. http://dx.doi.org/10.1111/j.1600-6143.2012.04332.x.

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9

Breneman, James C. "Immunology of Delayed Food Allergy." Otolaryngology–Head and Neck Surgery 113, no. 6 (December 1995): 701–4. http://dx.doi.org/10.1016/s0194-59989570008-0.

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Studies here and abroad are stockpiling evidence that immunoglobulin E explains only a small part of food allergy. Involvement of the entire immune system is evident if the more prevalent delayed-type food allergy is to be explained. To adequately diagnose food hypersensitivity a testing technique must be used that identifies delayed food allergy, such as the patch test here described, along with a test that diagnoses immediate immunoglobulin E-mediated food allergy.

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10

Cicalese, L., W. M. Halfter, P. F. Heeckt, W. H. Schraut, and A. J. Bauer. "Immunology and functional sequelae of acute rejecting rat small intestinal allografts." Gastroenterology 107, no. 4 (October 1994): 1232. http://dx.doi.org/10.1016/0016-5085(94)90325-5.

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11

Martin, Richard J. "Small airways symposium." Journal of Allergy and Clinical Immunology 124, no. 6 (December 2009): S71. http://dx.doi.org/10.1016/j.jaci.2009.07.063.

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12

Sherry, Barbara, and Anthony Cerami. "Small cytokine superfamily." Current Opinion in Immunology 3, no. 1 (January 1991): 56–60. http://dx.doi.org/10.1016/0952-7915(91)90077-e.

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13

Wood, Richard F. M., and A. Graham Pockley. "Small bowel transplantation." Transplant Immunology 2, no. 2 (June 1994): 163–66. http://dx.doi.org/10.1016/0966-3274(94)90055-8.

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14

Jung, Chi Young, and Scott J. Antonia. "Tumor Immunology and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer." Tuberculosis and Respiratory Diseases 81, no. 1 (2018): 29. http://dx.doi.org/10.4046/trd.2017.0120.

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15

Nitsche, Lindsay Joyce, Sarbajit Mukherjee, Kareena Cheruvu, Cathleen Krabak, Rohit Rachala, Kalyan Ratnakaram, Priyanka Sharma, Maddy Singh, and Sai Yendamuri. "Exploring the Impact of the Obesity Paradox on Lung Cancer and Other Malignancies." Cancers 14, no. 6 (March 11, 2022): 1440. http://dx.doi.org/10.3390/cancers14061440.

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There is a paradoxical relationship between obesity, as measured by BMI, and many types of cancer, including non-small-cell lung cancer. Obese non-small-cell lung cancer patients have been shown to fare better than their non-obese counterparts. To analyze the multifaceted effects of obesity on oncologic outcomes, we reviewed the literature on the obesity paradox, methods to measure adiposity, the obesity-related derangements in immunology and metabolism, and the oncologic impact of confounding variables such as gender, smoking, and concomitant medications such as statins and metformin. We analyzed how these aspects may contribute to the obesity paradox and cancer outcomes with a focus on lung cancer. We concluded that the use of BMI to measure adiposity is limited and should be replaced by a method that can differentiate abdominal obesity. We also concluded that the concomitant metabolic and immunologic derangements caused by obesity contribute to the obesity paradox. Medications, gender, and smoking are additional variables that impact oncologic outcomes, and further research needs to be performed to solidify the mechanisms.

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16

Henning, Stefan, and Steve Cleverley. "Small GTPases in lymphocyte biology." Immunologic Research 20, no. 1 (August 1999): 29–42. http://dx.doi.org/10.1007/bf02786505.

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17

Guo, Zhongxin, Yang Li, and Shou-Wei Ding. "Small RNA-based antimicrobial immunity." Nature Reviews Immunology 19, no. 1 (October 9, 2018): 31–44. http://dx.doi.org/10.1038/s41577-018-0071-x.

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18

Wood, R. F. M., and C. L. Ingham Clark. "Small bowel transplantation: future prospects." Immunology Letters 29, no. 1-2 (July 1991): 157–59. http://dx.doi.org/10.1016/0165-2478(91)90219-z.

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19

McManus, Michael T. "Small RNAs and Immunity." Immunity 21, no. 6 (December 2004): 747–56. http://dx.doi.org/10.1016/j.immuni.2004.11.007.

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20

Lin, Hui, Pingfang Song, Yi Zhao, Li-Jia Xue, Yi Liu, and Cong-Qiu Chu. "Targeting Th17 Cells with Small Molecules and Small Interference RNA." Mediators of Inflammation 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/290657.

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T helper 17 (Th17) cells play a central role in inflammatory and autoimmune diseases via the production of proinflammatory cytokines interleukin- (IL-) 17, IL-17F, and IL-22. Anti-IL-17 monoclonal antibodies show potent efficacy in psoriasis but poor effect in rheumatoid arthritis (RA) and Crohn’s disease. Alternative agents targeting Th17 cells may be a better way to inhibit the development and function of Th17 cells than antibodies of blocking a single effector cytokine. Retinoic acid-related orphan receptor gamma t (RORγt) which acts as the master transcription factor of Th17 differentiation has been an attractive pharmacologic target for the treatment of Th17-mediated autoimmune disease. Recent progress in technology of chemical screen and engineering nucleic acid enable two new classes of therapeutics targeting RORγt. Chemical screen technology identified several small molecule specific inhibitors of RORγt from a small molecule library. Systematic evolution of ligands by exponential enrichment (SELEX) technology enabled target specific aptamers to be isolated from a random sequence oligonucleotide library. In this review, we highlight the development and therapeutic potential of small molecules inhibiting Th17 cells by targeting RORγt and aptamer mediated CD4+T cell specific delivery of small interference RNA against RORγt gene expression to inhibit pathogenic effector functions of Th17 lineage.

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21

Betancor, Diana, Blanca Barroso Garcia, Victoria Villalobos Violan, Rosialzira Natasha Vera, and Mar Del Mar Fernandez-Nieto. "Does small airway predict bronchial hyperresponsiveness? An observational retrospective study to evaluate small airways dysfunction." Journal of Allergy and Clinical Immunology 143, no. 2 (February 2019): AB13. http://dx.doi.org/10.1016/j.jaci.2018.12.040.

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22

Jachimowicz, Lauren A., Peifang Ye, Yan Lu, Garret Guenther, and LI Nancy. "Detection of small particles by flow cytometry: Analysis of small particle beads and extracellular vesicles." Journal of Immunology 202, no. 1_Supplement (May 1, 2019): 130.17. http://dx.doi.org/10.4049/jimmunol.202.supp.130.17.

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Abstract The importance of cell-derived small particles has recently been recognized in multiple biological processes and is an increasing topic of investigation in biomedical research. Extracellular vesicles (EV) are cell-derived membranous vesicles that include exosomes, microvesicles, and apoptotic bodies. Small particle analysis by flow cytometry can bring much needed discoveries in small particle research, with the capability to detect rare events in significant numbers as well as measure surface protein levels. However, traditional flow cytometers were not capable of resolving them due to their small diameter and variable composition. The aim of this investigation is to determine the capacities of the NovoCyte QuanteonTM flow cytometer to resolve small particles, using both beads and cell-derived EV. We first performed analysis of three commercially available small particle bead mixes ranging in size of 100nm-1300nm and determined the Quanteon is able to resolve beads as small as 100nm. Since beads scatter more light than similar sized membranous particles, it is important to measure biological samples to test the detection limits of the Quanteon. Therefore, HEK293 derived GFP lipoparticles were analyzed for scatter resolution and GFP expression. In addition, plasma was analyzed for purified EV with and without ADP addition, a molecule known to induce platelet activation and EV release. Next, EV from a cancer cell line, SW480, was analyzed for known EV markers CD9, CD81, and AnnexinV. The Quanteon was able to effectively analyze lipoparticles and secreted EV. In conclusion, the NovoCyte Quanteon equipped with new technologies allows better discrimination of small particles and provide increased capacity for research into EV.

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23

Walser-Kuntz, Debby. "Academic civic engagement in the Immunology classroom: from grant proposals to immunology theater (EDU1P.255)." Journal of Immunology 192, no. 1_Supplement (May 1, 2014): 49.9. http://dx.doi.org/10.4049/jimmunol.192.supp.49.9.

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Abstract There is a growing recognition and sense of urgency that scientists need to be better equipped to communicate scientific ideas to the general public. Improved communication is an opportunity with significant policy, behavior, and funding implications. For the past 5 years, I have integrated civic engagement projects into the upper-level Immunology course I teach at Carleton College - a small liberal arts college located in Northfield, MN - in order to provide an opportunity for students to practice translating complex, jargon-rich information into engaging materials for use in the local community. These projects are by nature reciprocal; they provide an authentic learning opportunity for students and a very real benefit for our community partners. Additional student outcomes include increased awareness of local public health issues, enhanced understanding of the connection between immunology and real world problems, and improved scientific communication skills, including in some cases, grant writing skills. Civic engagement projects range from writing grant proposals or research reports for local nonprofit organizations to performing “Immunology Theater” with at-risk high school students or developing comics and videos to teach about sexually transmitted diseases. Assessment of the effectiveness and impact of the civic engagement projects included alumni surveys (2009-2013 graduates; n=192), evaluation of student reflections, and community partner surveys.

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24

Luban, Naomi L. C. "Not just a small adult." Transfusion 42, no. 6 (June 2002): 666–68. http://dx.doi.org/10.1046/j.1537-2995.2002.00177.x.

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25

Kalden, P., T. Krause, B. Volk, H. H. Peter, and J. von Kempis. "Myositis of small foot muscles." Rheumatology International 18, no. 2 (August 20, 1998): 79–82. http://dx.doi.org/10.1007/s002960050061.

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26

Minton, Kirsty. "ILC3s take control in small intestine." Nature Reviews Immunology 19, no. 6 (April 12, 2019): 353. http://dx.doi.org/10.1038/s41577-019-0166-z.

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27

Levantovsky, Rachel, and Nicolas Vabret. "Hydroxychloroquine: small effects in mild disease." Nature Reviews Immunology 20, no. 6 (April 14, 2020): 350. http://dx.doi.org/10.1038/s41577-020-0315-4.

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28

Cottini, Marcello, Carlo Lombardi, Alvise Berti, and Pasquale Comberiati. "Small-airway dysfunction in paediatric asthma." Current Opinion in Allergy & Clinical Immunology 21, no. 2 (January 18, 2021): 128–34. http://dx.doi.org/10.1097/aci.0000000000000728.

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29

Schepens, Bert, Dorien De Vlieger, and Xavier Saelens. "Vaccine options for influenza: thinking small." Current Opinion in Immunology 53 (August 2018): 22–29. http://dx.doi.org/10.1016/j.coi.2018.03.024.

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30

Schulz, Olga, and Oliver Pabst. "Antigen sampling in the small intestine." Trends in Immunology 34, no. 4 (April 2013): 155–61. http://dx.doi.org/10.1016/j.it.2012.09.006.

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31

DeMaio, Andrew, and Daniel Sterman. "Bronchoscopic intratumoural therapies for non-small cell lung cancer." European Respiratory Review 29, no. 156 (June 16, 2020): 200028. http://dx.doi.org/10.1183/16000617.0028-2020.

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The past decade has brought remarkable improvements in the treatment of non-small cell lung cancer (NSCLC) with novel therapies, such as immune checkpoint inhibitors, although response rates remain suboptimal. Direct intratumoural injection of therapeutic agents via bronchoscopic approaches poses the unique ability to directly target the tumour microenvironment and offers several theoretical advantages over systemic delivery including decreased toxicity. Increases in understanding of the tumour microenvironment and cancer immunology have identified many potential options for intratumoural therapy, especially combination immunotherapies. Herein, we review advances in the development of novel bronchoscopic treatments for NSCLC over the past decade with a focus on the potential of intratumoural immunotherapy alone or in combination with systemic treatments.

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32

Moticka, Edward. "Integrating immunology into a case based medical curriculum (51.3)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 51.3. http://dx.doi.org/10.4049/jimmunol.186.supp.51.3.

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Abstract Several innovations in the delivery of the pre-clinical medical curriculum have focused on non-discipline approaches. These include Problem Based Learning, Team Based Learning and the Clinical Presentation (CP) Curriculum. All these approaches require the integration of various science disciplines into clinical scenarios organized by organ systems. The CP Curriculum involves integrating didactic material in the context of approximately 125 clinical presentations (i.e. chest pain, hematuria, shortness of breath). During the pre-clinical years, a clinician provides an overview of the clinical problems which might be seen followed by a series of basic science presentations relevant to the clinical presentation. Incorporation of immunology into a CP curriculum requires coverage of both basic concepts and pathophysiology of immunologic diseases in each organ system. Our approach is to use a small number of clinical presentations (sore throat, recurrent infections) to cover basic concepts. This is followed by presentations in each organ system during which disease mechanisms and additional immunological concepts are introduced. This presentation will review the ability to include topics identified by USMLE as well as those identified by ASM in such a curriculum along with data on the performance of students enrolled in a medical school using this approach.

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33

O'Connell, David. "Small is beautiful." Nature Reviews Microbiology 3, no. 7 (July 2005): 520. http://dx.doi.org/10.1038/nrmicro1196.

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34

Goulet, Olivier. "Small bowel transplantation." Current Opinion in Organ Transplantation 4, no. 4 (December 1999): 333. http://dx.doi.org/10.1097/00075200-199912000-00006.

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35

Tzakis, Andreas G. "Small bowel transplantation." Current Opinion in Organ Transplantation 5, no. 3 (September 2000): 277–78. http://dx.doi.org/10.1097/00075200-200009000-00019.

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36

Fryer, Jonathan P., and Kenneth A. Newell. "Small bowel transplantation." Current Opinion in Organ Transplantation 9, no. 2 (June 2004): 225–32. http://dx.doi.org/10.1097/01.mot.0000127451.07864.56.

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37

Osterman, Mark T. "Big risk, small risk: Small bowel cancer in Crohnʼs disease." Inflammatory Bowel Diseases 15, no. 9 (September 2009): 1434–35. http://dx.doi.org/10.1002/ibd.20888.

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38

Michael McCoy. "Roche licenses Repare small molecule." C&EN Global Enterprise 100, no. 20 (June 6, 2022): 13. http://dx.doi.org/10.1021/cen-10020-buscon14.

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39

Benam, Kambez Hajipouran. "Organ-on-Chip Meets Immunology: Let’s Start with the Lungs." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 159.14. http://dx.doi.org/10.4049/jimmunol.204.supp.159.14.

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Abstract Organs-on-chips are biomimetic, microfluidic, cell culture devices created with microchip manufacturing methods that contain continuously perfused hollow microchannels inhabited by living tissue cells arranged to simulate organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interfaces, chemical gradients, mechanical cues, and vascular perfusion of the body, these devices produce levels of tissue and organ functionality not possible with conventional 2D or 3D culture systems. They also enable high-resolution, real-time imaging and in vitro analysis of biochemical, genetic and metabolic activities of living human cells in a functional human tissue and organ context. Here, we discuss development of ‘Human Lung Small Airway-on-a-Chip’ – an engineered cell-by-cell reconstituted microfluidic device with living human tissues to model airway inflammation in the context of debilitating lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). In addition, we will present our preliminary data on recreating a hematopoietically active bone marrow niche in vitro (‘BM-on-a-Chip’) for microphysiological integration with the Small Airway-on-a-Chip to emulate innate immune cell egress into circulation (from the BM) and their recruitment to the lung airway.

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40

Dinkel, Brittney A. "Teaching Undergraduate Immunology Using Journal Club Discussions and Case Studies." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 222.5. http://dx.doi.org/10.4049/jimmunol.204.supp.222.5.

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Abstract With immunology being a rapidly progressing field, it is important to not only teach the basic immunology concepts but also teach current methods and navigation of primary literature. Based off our curriculum, students entering the 400-level immunology course already have had a brief introduction to immunology through the microbiology course. This allows us to dive more deeply into the material using primary literature and regular journal club discussions. Approximately half of the class each week provides background information and key concepts. The second half of the class each week is focused around either a recent publication focused around the concepts discussed during lecture or a case study that works to incorporate the understanding of multiple concepts into a disease or related condition. The journal clubs not only increase the depth and level of understanding around the topics but also works to expose students at small liberal arts colleges to techniques and data analysis that cannot be done on campus due to various limitations. Assessment is based off paper discussion forms, in-class discussion participation, and ability to analyze data and apply the knowledge during an exam.

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41

Greene, Russell T., and Stefan Schwarz. "Small antibiotic resistance plasmids in Staphylococcus intermedius." Zentralblatt für Bakteriologie 276, no. 3 (February 1992): 380–89. http://dx.doi.org/10.1016/s0934-8840(11)80545-1.

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42

Gazdar, Adi F., and John D. Minna. "Small cell lung cancers made from scratch." Journal of Experimental Medicine 216, no. 3 (February 13, 2019): 476–78. http://dx.doi.org/10.1084/jem.20182216.

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In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a different method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al. 2018. Science. https://doi.org/10.1126/science.aat5749). These approaches and their models provide important new resources for developing diagnostic, preventative, and therapeutic approaches for high-grade NE tumors.

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43

Thorshauge, H., I. Fallesen, and P. Aa Østergaard. "Farmer's lung in infants and small children." Allergy 44, no. 2 (February 1989): 152–55. http://dx.doi.org/10.1111/j.1398-9995.1989.tb02238.x.

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44

Neschadim, Anton, Lakshmi P. Kotra, and Donald R. Branch. "Small molecule phagocytosis inhibitors for immune cytopenias." Autoimmunity Reviews 15, no. 8 (August 2016): 843–47. http://dx.doi.org/10.1016/j.autrev.2016.06.004.

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45

van der Zanden, Sabina Y., Jolien J. Luimstra, Jacques Neefjes, Jannie Borst, and Huib Ovaa. "Opportunities for Small Molecules in Cancer Immunotherapy." Trends in Immunology 41, no. 6 (June 2020): 493–511. http://dx.doi.org/10.1016/j.it.2020.04.004.

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46

Alvarez-Gonzalez, Juan Antonio, Robert Maul, Rahul M. Kohli, and Patricia J. Gearhart. "Small molecule inhibitors of Activation-Induced Deaminase." Journal of Immunology 200, no. 1_Supplement (May 1, 2018): 48.18. http://dx.doi.org/10.4049/jimmunol.200.supp.48.18.

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Abstract Activation-Induced Deaminase (AID) is a cytosine deaminase that converts cytosine into uracil in DNA, which initiates a cascade of mutagenic DNA repair to introduce point mutations and double-strand breaks. Specific targeting of AID to the immunoglobulin heavy chain locus promotes somatic hypermutation in antibody variable genes for affinity maturation, and breaks in switch regions for class switch recombination (CSR). However, mis-targeting of AID to other loci could initiate tumor development and lead to greater drug resistance among cancer cells when continually expressed. To identify a small molecule inhibitor of AID, we screened ~400,000 compounds in conjunction with the NCATS core facility at NIH. Using FRET based analysis of cytosine deamination, we identified 150 potential inhibitors of AID catalytic activity. To confirm biological function, we examined their effects on CSR in an in vitro murine B-cell activation assay using CH12 cells, wherein 30 were confirmed inhibitor candidates. We then selected the top seven molecules to proceed with further characterization in wild type primary splenocytes, and found two near-identical compounds that had inhibitory activity. From these structures, we tested commercially available analogues and identified two molecules with inhibitory efficacy in the nanomolar range. Using these approaches, we hope to identify a small molecule with great efficacy and low toxicity for use as a molecular probe to further characterize AID’s intricacies, or even as a therapeutic agent.

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47

McDole, Jeremiah, Leroy Wheeler, Rodney Newberry, and Mark Miller. "A small intestine trans-epithelial conduit system assists in lamina propria DC sampling (90.2)." Journal of Immunology 184, no. 1_Supplement (April 1, 2010): 90.2. http://dx.doi.org/10.4049/jimmunol.184.supp.90.2.

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Abstract The mechanisms by which lamina propria DCs sample antigens from the gut remains a crucial topic in mucosal immunology. DCs acquire antigen by several distinct processes including M cell transcytosis, specialized transport involving the neonatal Fc receptor, paracellular leak and by DC trans-epithelial dendrite extension. The continuous sampling of luminal contents by gut resident DCs could both contribute to rapid pathogen recognition and provide normal flora and food antigens for tolerance induction. We used two-photon microscopy, to examine DC sampling behavior in vivo and discovered a previously unreported small-intestine-trans-epithelial-conduit (SiTEC) system. We found that SiTECs could carry macromolecules across the epithelium to the lamina propria where they were taken up by resident DCs. SiTECs have a functional molecular weight cut-off of approximately 70kD based on dextran permeability and can pass small proteins as well. The SiTEC system presents a simple mechanism to deliver luminal antigens to lamina propria DCs for the maintenance of tolerance in the steady-state.

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48

Holliger, P., and Greg Winter. "Diabodies: small bispecific antibody fragments." Cancer Immunology, Immunotherapy 45, no. 3-4 (November 24, 1997): 128–30. http://dx.doi.org/10.1007/s002620050414.

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49

Lacomis, David, Michael J. Giuliani, Virginia Steen, and Henry C. Powell. "Small fiber neuropathy and vasculitis." Arthritis & Rheumatism 40, no. 6 (June 1997): 1173–77. http://dx.doi.org/10.1002/art.1780400624.

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50

Butcher, Brian T., and Daniel E. Banks. "IMMUNOLOGIC AND CLINICAL FEATURES OF OCCUPATIONAL ASTHMA ATTRIBUTABLE TO SMALL MOLECULAR WEIGHT AGENTS." Immunology and Allergy Clinics of North America 12, no. 2 (May 1992): 329–47. http://dx.doi.org/10.1016/s0889-8561(22)00112-6.

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