Dissertations / Theses on the topic 'Small animal imaging'
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Evans, Eleanor. "Improved quantification in small animal PET/MR." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/252640.
Full textWeisenberger, Andrew Gerard. "Gamma-ray imaging detector for small animal research." W&M ScholarWorks, 1998. https://scholarworks.wm.edu/etd/1539623944.
Full textLarsson, Daniel. "Small-Animal Imaging with Liquid-Metal-Jet X-Ray Sources." Doctoral thesis, KTH, Biomedicinsk fysik och röntgenfysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-163169.
Full textRöntgenavbildning av små försöksdjur är en viktig metod inom medicinsk forskning. Röntgenstrålar penetrerar material, vilket gör det möjligt att undersöka 3D-strukturen hos försöksdjur och andra tjocka biologiska prov med hjälp av datortomografi (CT). Tyvärr kräver smådjursavbildning ofta dels hög upplösning, eftersom de relevanta strukturerna är små, dels korta exponeringstider, eftersom objektet tenderar att röra sig. Detta är en utmaning, då båda egenskaperna kräver kompakta röntgenkällor med speciella egenskaper som inte är brett tillgängliga. I denna avhandling visar vi den första användningen av metallstråleröntgenkällor för avbildning av hela smådjur. Den här typen av röntgenkälla uppfanns vid KTH för drygt tio år sedan. Genom att låta elektronerna träffa en stråle av flytande metall, istället för en solid metallanod, kan vi generera mer röntgenstrålning men samtidigt behålla en liten källpunkt, vilket behövs för avbildning med hög upplösning. En ny metallstrålekälla utvecklades som en del av denna avhandling. Den ger ett röntgenspektrum med högre energier, vilket gör källan mer lämpad än tidigare källor för avbildning av små försöksdjur och andra centimetertjocka biologiska objekt. Vi har använt metallstrålekällor för att avbilda intakta, avlivade möss och zebrafiskar. Med högupplöst absorptions-CT har vi detekterat små bendetaljer inuti möss. Vi har även använt faskontrastavbildning, en ny metod som avsevärt kan förbättra avbildning av mjukvävnad, till att demarkera millimeterstora tumörer inuti en hel mus, samt för avbildning av brosk i leder hos möss. Faskontrast ger en kraftig förstärkning av kontrasten i bilden, vilket även har använts för att för första gången detektera individuella muskelfibrer (och eventuellt även myofibriller) inuti zebrafiskar med en kompakt röntgenkälla. Muskelstrukturerna har diametrar på 5-7 μm och låg kontrast, vilket gör dem svåra att observera. Med hjälp av faskontrast har vi utvecklat en metod för att avbilda blodkärl med diametrar under 10 μm inuti organ och vävnader från möss och råttor ex vivo, med stråldoser som är kompatibla med studier av levande smådjur. Detta är inte möjligt med konventionell absorptionskontrast och jod-baserade kontrastmedel. Vi har dessutom avbildat nyformade blodkärl kring tumörer i musöron och observerat kärlens kaotiska struktur. Slutligen presenterar vi de första resultaten från en prototyp av en ny högeffektskälla. Källan har tio gånger högre effekt än tidigare metallstrålekällor, men bibehåller samma storlek på källpunkten. Den här högeffektskällan är ett viktigt steg mot framtida laboratoriebaserad avbildning av levande små försöksdjur med hög upplösning.
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Qian, Jianguo. "A versatile imaging system for in vivo small animal research." W&M ScholarWorks, 2008. https://scholarworks.wm.edu/etd/1539623532.
Full textTerrin, Massimo. "Micro-CT for small animal imaging : Optimization of the tube voltage for low-contrast imaging." Thesis, KTH, Skolan för teknik och hälsa (STH), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176482.
Full textManivannan, Niranchana. "Use of Multiple Imaging Views for Improving Image Quality in Small Animal MR Imaging Studies." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1436753010.
Full textDaibes, Figueroa Said. "Discrete NaI(TI) crystal detector optimization for small animal SPECT molecular imaging." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/5821.
Full textThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (November 15, 2006) Vita. Includes bibliographical references.
Kujala, Naresh Gandhi Yu Ping. "Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/7021.
Full textCooper, Reynold James. "Performance of the SmartPET Positron Emission Tomography System for Small Animal Imaging." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491374.
Full textValastyán, Iván. "Software Solutions for Nuclear Imaging Systems in Cardiology, Small Animal Research and Education." Doctoral thesis, KTH, Medicinsk teknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12069.
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Citro, Lucas Abraham. "High-field Cardiac Magnetic Resonance Imaging in Small Animal Models of Cardiovascular Disease." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1365082830.
Full textRasmussen, John C. "Development of a radiative transport based, fluorescence-enhanced, frequency-domain small animal imaging system." Thesis, [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1067.
Full textAmbrosini, Valentina <1975>. "Pre-clinical imaging: small animal pet and CT applications in pneumology, oncology and cardiology." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/1087/.
Full textKonik, Arda Bekir. "Evaluation of attenuation and scatter correction requirements in small animal PET and SPECT imaging." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/691.
Full textHesterman, Jacob Yost. "The Multi-Module, Multi-Resolution SPECT System: A Tool for Variable-Pinhole, Small-Animal Imaging." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/196056.
Full textTrumbull, Tara. "Simulation and Analysis of an Adaptive SPECT Imaging System for Tumor Estimation." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/144580.
Full textAkinyi, Teckla G. "An Affordable Open-Source Small Animal MR and Hyperpolarized Gas Compatible Ventilator: Feasibility in preclinical imaging." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490354672385997.
Full textVandervoort, Eric. "Improving attenuation corrections obtained using singles-mode transmission data in small-animal PET." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/608.
Full textKwon, Sun Kuk. "Dynamic fluorescence imaging with molecular agents for cancer detection." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1064.
Full textRoy, Debashish. "3D Cryo-Imaging System For Whole Mouse." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1259006676.
Full textŞensoy, Levent. "Geo-Pet : a novel generic Organ-Pet for small animal organs and tissues." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3186.
Full textTapfer, Arne [Verfasser], Franz [Akademischer Betreuer] Pfeiffer, and Axel [Akademischer Betreuer] Haase. "Small Animal X-ray Phase-Contrast Imaging / Arne Tapfer. Gutachter: Axel Haase ; Franz Pfeiffer. Betreuer: Franz Pfeiffer." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/104227701X/34.
Full textAttarwala, Ali Asgar [Verfasser], and Frederik [Akademischer Betreuer] Wenz. "Development and evaluation of quantitative imaging for improved estimation of radiopharmaceutical bio-distribution in small animal imaging / Ali Asgar Attarwala ; Betreuer: Frederik Wenz." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1177688883/34.
Full textEdjlali, Ehsan. "Fluorescence diffuse optical tomographic iterative image reconstruction for small animal molecular imaging with continuous-wave near infrared light." Thèse, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/10673.
Full textAbstract : The simplified spherical harmonics (SPN) approximation to the radiative transfer equation has been proposed as a reliable model of light propagation in biological tissues. However, few analytical solutions have been found for this model. Such analytical solutions are of great value to validate numerical solutions of the SPN equations, which must be resorted to when dealing with media with complex curved geometries. In the first part of this thesis, analytical solutions for two curved geometries are presented for the first time, namely for the sphere and for the cylinder. For both solutions, the general refractiveindex mismatch boundary conditions, as applicable in biomedical optics, are resorted to. These solutions are validated using mesh-based Monte Carlo simulations. So validated, these solutions allow in turn to rapidly validate numerical code, based for example on finite differences or on finite elements, without requiring lengthy Monte Carlo simulations. provide reliable tool for validating numerical simulations. In the second part, iterative reconstruction for fluorescence diffuse optical tomography imaging is proposed based on an Lq-Lp framework for formulating an objective function and its regularization term. To solve the imaging inverse problem, the discretization of the light propagation model is performed using the finite difference method. The framework is used along with a multigrid mesh on a digital mouse model. The inverse problem is solved iteratively using an optimization method. For this, the gradient of the cost function with respect to the fluorescent agent’s concentration map is necessary. This is calculated using an adjoint method. Quantitative metrics resorted to in medical imaging are used to evaluate the performance of the framework under different conditions. The results obtained support this new approach based on an Lq-Lp formulation of cost functions in order to solve the inverse fluorescence problem with high quantified performance.
Pesnel, Sabrina. "Développement de modalités d'imagerie in vivo pour l'oncologie expérimentale." Phd thesis, Université d'Orléans, 2010. http://tel.archives-ouvertes.fr/tel-00597262.
Full textFoudray, Angela Marie Klohs. "Design of an advanced positron emission tomography detector system and algorithms for imaging small animal models of human disease." Diss., [La Jolla, Calif.] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3344655.
Full textTitle from first page of PDF file (viewed March 19, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 404-423).
Choi, Woo Jhon. "Structural and functional imaging of the human and small animal eyes using ultrahigh speed Fourier domain optical coherence tomography." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/93058.
Full textCataloged from PDF version of thesis.
Includes bibliographical references.
Optical coherence tomography (OCT) is a non-invasive optical imaging technique that allows the three-dimensional structure of biological tissue to be visualized with micrometer resolution. In ophthalmology OCT has the unique advantage that it provides cross-sectional images of the retina and choroid noninvasively and in vivo, which have led OCT to be a clinical standard for the diagnosis of a variety of retinal diseases. Although current commercial Fourier domain OCT systems have high imaging speeds of 20-100kHz A-scan rates, these imaging speeds are not sufficient for more advanced structural and functional imaging techniques. Current state-of-the-art spectral domain and swept source OCT provide ultrahigh imaging speeds of >200kHz A-scan rates. These speeds enable functional imaging of retinal blood flow, OCT angiography of the retinal and choroidal microvasculature, and wide field volumetric structural imaging of the retina and choroid. In this thesis, advances in structural and functional ophthalmic imaging techniques for the human and small animal eyes are investigated using ultrahigh speed Fourier domain OCT. The following topics are discussed: (1) a method for numerically extracting and compensating dispersion mismatch in ultrahigh resolution spectral domain OCT, (2) ultrahigh speed spectral domain imaging in the small animal eye for measuring total retinal blood flow, (3) development of ultrahigh speed phase stable swept source OCT system for human retinal imaging, (4) OCT angiography of the choriocapillaris in the human eye, (5) clinical applications of OCT angiography in retinal diseases, including diabetic retinopathy and age-related macular degeneration, (6) small animal anesthesia protocol for functional hemodynamic imaging, and (7) imaging of neurovascular coupling in small animals using ultrahigh speed OCT.
by Woo Jhon Choi.
Ph. D.
Ma, Rui Verfasser], Vasilis [Akademischer Betreuer] Ntziachristos, and Thorsten [Akademischer Betreuer] [Hugel. "Development of multispectral optoacoustic imaging for high resolution small animal visualization / Rui Ma. Gutachter: Thorsten Hugel ; Vasilis Ntziachristos. Betreuer: Vasilis Ntziachristos." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1031075488/34.
Full textAkkoul, Smaïl. "Filtrage et déconvolution en imagerie de bioluminescence chez le petit animal." Phd thesis, Université d'Orléans, 2010. http://tel.archives-ouvertes.fr/tel-00585392.
Full textDi, Sopra Lorenzo. "Geometric Misalignment Calibration and Detector Lag Effect Artifact Correction in a Cone-Beam Flat Panel micro-CT System for Small Animal Imaging." Thesis, KTH, Skolan för teknik och hälsa (STH), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-179873.
Full textLefrançois, William. "Développements méthodologiques en imagerie cardiovasculaire par résonance magnétique chez le petit animal." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21833/document.
Full textCardiovascular MRI in rodents is a real challenge in terms of spatial and temporal resolution, contrast and experiment times. Though it is accepted that 3D acquisition should be preferred in small animals, 3D acquisition times can be very long. However, they must remain compatible with in vivo experiment times. The aim of this thesis was therefore to develop new fast 3D methods of cardiovascular imaging in small animals at 4.7 and 9.4 T. First, two 4D cardiac MRI methods (3D time resolved) were developed in «black-blood» contrast. The first method is based on a TrueFISP sequence (Fast Imaging with Steady-state Precession). It allowed to make black blood contrast in one hour acquisition time. The second method is based on a FLASH sequence (Fast Low Angle Shot). It uses a bipolar gradient to suppress the blood signal and the contrast was enhanced by using Manganese. Thirty minutes were then enough. Next, a time-of-flight angiography method for the whole body of mice was developed. The vascular contrast was improved by adding preparation modules to suppress the signal from tissues. The imaging of the whole arterial tree was realized within less than ten minutes. Finally, a new 4D time-of-flight method of functional cine angiography with echo-planar acquisition was developed. Preliminary results showed that acquisition times could be divided by four compared with those in classical functional angiography. All these results show that high resolution 3D cardiovascular imaging is possible in reasonable or even fast acquisition times
Cosette, Jérémie. "Design and optimization of small animal non-invasive imaging approaches for evaluating the effects of innovative treatments of Primary Central Nervous System Lymphomas." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T069/document.
Full textPrimary central nervous system lymphomas (PCNSL) are very aggressive malignancies with poor survival rate even with treatments (survival median is 44 months). This disease affects immune cells (lymphocytes) and forms diffuse and non-surgically removable tumor in the central nervous system. High-dose chemotherapy and radiotherapy are the common treatments with severe side effects. New therapeutic approaches are required for increasing treatment efficiency. We focused on primary intraocular lymphomas (PIOL) and primary cerebral lymphomas (PCL), which are subtypes of PCNSL. PIOL and PCL cells have a high propensity to migrate and form metastases in the brain and in the controlateral eye in the case of PIOL, and in the eye in the PCL case. However, metastatic dissemation mechanisms remain unclear. The objective of the present work was to study the effects of innovative treatments of B-cell lymphoma on primary tumor, on metastases, and on circulating tumor cells in PIOL and PCL immunocompetent syngeneic murine models of lymphomas using non-invasive in vivo imaging methods. We studied the effects of Ublituximab, a glycoengineered anti-CD20 monoclonal antibody (mAb), and CpG-ODN, a TLR-9 agonist, in mouse models. We showed that Ublituximab exhibits significant anti-tumor effect in PIOL and PCL, while CpG showed significant anti-tumor effect in PCL. We monitored the tumor burden and metastases using innovating non-invasive optical imaging or cell detection methods: bioluminescence imaging (BLI) and in vivo flow cytometer (IVFC). BLI was used to locate metastasis and to quantify tumor burden. We indeed developed a bioluminescence-based tumor burden quantification method that reduces user-dependence, allows comparisons between experiments, reveals statistical relevance, and which is easy to use. An IVFC device was set up to investigate the role of circulating tumor cells (CTCs) in PIOL and PCL. This fluorescence-based technique allows detection of CTCs by analyzing the cells flowing in blood vessels. However we had to overcome the problem of autofluorescence and tissue absorption. Two approaches were studied in parallel: a elaborating new cell line expressing far red fluorescent proteins, modulating the excitation light of an IVFC device to give the cell a unique signature therefore enhancing sensitivity, increasing signal to noise ratio. The modulated excitation IVFC allowed us to calculate the velocity of cells, and infer their position in blood vessel phantoms. The analysis of treatment effects on tumor burden, metastases and CTCs in PIOL and PCL could help understanding lymphoma metastatic dissemination and contribute to treatment follow-up, thus allowing design of new therapeutic approaches with increased efficacy
Namati, Jacqueline Thiesse. "Phenotype characterization of lung structure in inbred mouse strains using multi modal imaging techniques." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/256.
Full textRabell, Montiel Adela. "Development of acoustic tissue mimicking materials for preclinical ultrasound imaging applications." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31342.
Full textDillenseger, Jean-Philippe. "Imagerie préclinique multimodale chez le petit animal : qualification des instruments et des méthodes (IRM, µTDM et µTEMP)." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAD026/document.
Full textPreclinical imaging is mostly performed on mouse animal models (61%). It is a necessary step in preclinical research, in compliance the first two recommendations of the 3Rs rules (reduction, refinement and replacement). In order to give a biological significance to measurements extracted from in vivo-acquired mouse images, it is necessary to evaluate instruments performances but also experimental procedures involved. The qualification of apparatuses requires the use of specific phantoms while the evaluation of methods requires procedures tests on non-pathological animals before experimentations. The scope of this work was to develop tools and methods to qualify imaging instruments and in vivo procedures. The need for quantification in small animal imaging, leads us to consider preclinical imaging instruments as metrological tools; which means integrating measurement uncertainty into
Bergeron, Mélanie. "Construction et expérimentation d'un scanner bimodal TEP/TDM combiné de résolution spatiale submillimétrique pour petits animaux." Thèse, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/6755.
Full textBrard, Emmanuel. "La tomographie à émission de positrons à géométrie axiale : de l’imagerie de la souris au cerveau humain." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAE003/document.
Full textPositrons emission tomography is a nuclear imaging technics using nuclear decays. It is used both in clinical and preclinical studies. The later requires the use of small animals such as the mouse. The objective is to obtain the best signal with the best spatial resolution. Yet, a weight ratio between humans and mice indicates the need of a sub-millimeter resolution. A conventional scanner is based on detection modules surrounding the object to image and arranged perpendicularly. This implies a strong relationship between efficiency and spatial resolution. This work focuses on the axial geometry in which detection modules are arranged parallel to the object. This limits the relationship between the figures of merit, leading to both high spatial resolution and efficiency. The simulations of prototypes showed great perspectives in term of sub-millimeter resolution with efficiencies of 15 or 40% according to the scanner’s axial extension. These results indicate great perspectives for both clinical and preclinical imaging
Ma, Xiaopeng [Verfasser], Vasilis [Akademischer Betreuer] [Gutachter] Ntziachristos, Moritz G. F. [Gutachter] Wildgruber, and Bernhard [Gutachter] Wolfrum. "Assessment of hybrid FMT-XCT for respiratory and cardiovascular small animal imaging applications / Xiaopeng Ma ; Gutachter: Moritz G. F. Wildgruber, Bernhard Wolfrum, Vasilis Ntziachristos ; Betreuer: Vasilis Ntziachristos." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1126644110/34.
Full textBled, Emilie. "Développements méthodologiques de l’IRM en 3D chez la souris : résolution temporelle et sensibilité du contraste." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR21934.
Full textIn vivo 3D MRI is a powerful method which can be used to answer emerging biological issues. However, low temporal resolution due to intrinsic low sensitivity is one of its main drawbacks. Similarly, breakthroughs are needed to detect by MRI low-concentrated contrast agents used for molecular imaging. In this work, several methodology developments in small animals are proposed to greatly reduce acquisition times of 3D MRI and to increase contrast sensitivity to T2* agents. Both achievements were performed through the manipulation of the k-space, i.e the acquired data space in a retrospective approach. To achieve very high temporal resolution a 3D keyhole technique was chosen. This allowed the acquisition time in cardiac 3D-cine imaging in mice to be reduced by a factor 4. Image quality (signal-to-noise ratio) and the extracted functional data were preserved. Interestingly, 3D keyhole imaging also allowed the evaluation of T1 and T2* contrast enhancement and biodistribution in real time in the whole mouse body. In the last part of the work, the goal was to generate highly T2*-sensitive 3D images in mouse abdomen to detect diluted iron-oxide-based contrast agents. The use of a navigator echo enabled efficient motion correction and detection threshold of less than 100 picomol iron per kilogram. The results are discussed in a general frame of future applications and development of fast and highly-resolved 3D imaging
Namati, Eman, and eman@namati com. "Pre-Clinical Multi-Modal Imaging for Assessment of Pulmonary Structure, Function and Pathology." Flinders University. Computer Science, Engineering and Mathematics, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081013.044657.
Full textOmidvari, Negar [Verfasser], Stephan [Akademischer Betreuer] Paul, Stephan [Gutachter] Paul, and Sibylle [Gutachter] Ziegler. "Development and Characterization of MADPET4: A High Resolution Small Animal Positron Emission Tomography Insert for a 7 T Magnetic Resonance Imaging Scanner / Negar Omidvari ; Gutachter: Stephan Paul, Sibylle Ziegler ; Betreuer: Stephan Paul." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1170872611/34.
Full textManook, André [Verfasser], Markus [Akademischer Betreuer] Schwaiger, and Johann [Akademischer Betreuer] Förstl. "Preclinical PET as Translational Tool for Imaging Alzheimer's Disease : Small-Animal PET Imaging of Beta-Amyloid Plaques with [11C]PiB, its Multi-Modal Validation and Application to the Evaluation and Ranking of New AD Tracers / André Manook. Gutachter: Markus Schwaiger ; Johann Förstl. Betreuer: Markus Schwaiger." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1047883465/34.
Full textKastis, Georgios. "Multi-modality imaging of small animals." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/289830.
Full textJiménez, González Xavier. "Improvements in the registration of multimodal medical imaging : application to intensity inhomogeneity and partial volume corrections." Doctoral thesis, Universitat Politècnica de Catalunya, 2016. http://hdl.handle.net/10803/458881.
Full textEl registre d'imatges mèdiques té un paper rellevant en les decisions de diagnòstic i tractament clíniques així com en la recerca. Amb el desenvolupament de noves tecnologies d'imatge multimodal, el registre robust d'informació funcional i anatòmica és encara avui un repte, en particular, en imatge de petit animal amb un menor contingut estructural que en humans de certes parts anatòmiques com el cervell. A més, els artefactes induïts pel propi pacient i per la tècnica d'adquisició que afecten el contingut d'informació de les imatges complica encara més el procés de registre. És el cas de les inhomogeneïtats d'intensitat (IIH) que apareixen a les RM i de l'efecte de volum parcial (PVE) característic en PET. Tot i que existeixen mètodes de referència pel registre acurat d'imatges la seva eficàcia es veu greument minvada en casos de poc solapament entre les imatges. De la mateixa manera, també existeixen mètodes per la correcció d'IIH i de PVE però que no garanteixen o que requereixen un registre robust. Aquesta tesi es centra en superar aquestes limitacions sobre el registre per habilitar nous mètodes per la correcció d'IIH i de PVE.
Portal, Loriane. "Etude de la tomographie à comptage de rayons X avec des pixels hybrides en Si et en CdTe et application au suivi longitudinal du carcinome hépatocellulaire chez la souris." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0351/document.
Full textMy PhD thesis is at the interface between experimental physics and biology. This work has been developed within the imXgam team at CPPM, which has built a micro-computed tomography prototype for the non-invasive longitudinal monitoring of small animal, equipped with the XPAD3 hybrid pixel camera that operates in X-ray photon counting mode. X-ray photon counting that has been made possible by hybrid pixels, allows to free images from the electronic noise and thus to increase detectability of weakly contrasted tissues. Moreover, it provides the possibility to set an energy threshold for each pixel that allows to accessing spectral information on the detected X-rays and paving the way to the development of a spectral imaging modality also named K-edge imaging, which allows to differentiate selected contrast agents. Actually, the XPAD3 camera developed with a Si sensor presents a low detective efficiency that limits its use for biomedical imaging. A XPAD3 camera with a better efficiency above 25 keV has been assembled with high-Z CdTe sensors. Firstly, we have performed a comparison of XPAD3/Si and XPAD3/CdTe cameras for standard absorption CT and K-edge imaging. Then, in collaboration with a team of biologists from IBDM, we have carried out the quantitative and in vivo follow-up of hepatic tumour development in a specific mouse model over several months, and of the effectiveness of a treatment targeting these tumour cells. Finally, we have developed a protocol for low dose acquisition of spectral data to realize an in vivo spectral tomography of a mouse liver using the barium spectral signature
Marchadier, Arnaud. "Analyses d'images de tomographie X chez le petit animal : applications aux études de phénotypage ex vivo et in vivo." Phd thesis, Université d'Orléans, 2011. http://tel.archives-ouvertes.fr/tel-00779806.
Full textBrullé, Laura. "Développement de stratégies d'imagerie multimodalités pour la pharmacologie des agents anticancéreux." Phd thesis, Université d'Orléans, 2012. http://tel.archives-ouvertes.fr/tel-00747343.
Full textOuamara, Hamid. "Comparaison de la micro-tomodensitométrie par comptage de photons et par intégration de charges avec le dispositif d'irradiation PIXSCAN." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4004/document.
Full textThe pathway that has been followed by the imXgam team at CPPM was to adapt the hybrid pixel technology XPAD to biomedical imaging. It is in this context that the micro-CT PIXSCAN II based on the new generation of hybrid pixel detectors called XPAD3 has been developed. This thesis describes the process undertaken to assess the contribution of the hybrid pixel technology in X-ray computed tomography in terms of contrast and dose and to explore new opportunities for biomedical imaging at low doses. Performance evaluation as well as the validation of the results obtained with data acquired with the detector XPAD3 were compared to results obtained with the CCD camera DALSA XR-4 similar to detectors used in most conventional micro-CT systems. The detector XPAD3 allows to obtain reconstruced images of satisfactory quality close to that of images from the DALSA XR-4 camera, but with a better spatial resolution. At low doses, the images from the detector XPAD3 have a better quality that is those from CCD camera. From an instrumentation point of view, this project demonstrated the proper erations of the device PIXSCAN II for mouse imaging. We were able to reproduce an image quality similar to that obtained with a charge integration detector such as a CCD camera. To improve the performance of the detector XPAD3, we will have to optimize the stability of the thresholds and in order to obtain more homogeneous response curves of the pixels as a function as energy by using a denser sensor such as CdTe
Song, Yang. "Semi-Automatic Registration Utility for MR Brain Imaging of Small Animals." Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-theses/148.
Full textFang, Yu-Hua. "Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1238635584.
Full textDepartment of Biomedical Engineering Abstract Title from OhioLINK abstract screen (viewed on 10 April 2009) Available online via the OhioLINK ETD Center