Academic literature on the topic 'Skipped cycles'
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Journal articles on the topic "Skipped cycles":
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Burlon, S., H. Mroueh, and J. P. Cao. "‘Skipped cycles’ method for studying cyclic loading and soil–structure interface." Computers and Geotechnics 61 (September 2014): 209–20. http://dx.doi.org/10.1016/j.compgeo.2014.05.007.
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Cucco, Marco, Marco Grenna, and Irene Pellegrino. "Egg Characteristics in Relation to Skipped Days of Laying in the Grey Partridge." Avian Biology Research 10, no. 4 (November 2017): 231–40. http://dx.doi.org/10.3184/175815617x15036738758853.
Abstract:
Birds sometimes skip a day along the sequence of egg laying, which may vary the mass or the composition of delayed eggs compared with those that were laid consecutively. Our literature review shows that this has been interpreted as a short-term adaptation that enables females to overcome energetic constraints during the laying period, but other hypotheses implying the influence of weather, pollution, or hormonal cycles have also been proposed. We collected freshly laid Grey Partridge Perdix perdix eggs to determine the effects of laying gaps on egg characteristics. Egg shape, as well as egg components (beta-carotene, avidin and lysozyme concentrations) did not vary in relation to skipped days. Eggs were slightly heavier when one or two days were skipped (0.72% and 0.45%, respectively). However, when examining the hatching rate, we found a significant decrease in relation to skipped days, hence eggs following laying gaps showed a lower hatching rate than other eggs. The pattern observed could indicate the presence of some physiological stress that caused females to skip one or two days and to lay eggs that hatched less.
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Mäeorg, Uno, Andi Kipper, Indrek Kalvet, Kaido Tämm, Lauri Sikk, Peeter Burk, and Kuldar Kõiv. "Synthesis of Unprotected CH2-Skipped Piperazine-Pyridine Alternating Cycles with Azide End-Group." HETEROCYCLES 90, no. 1 (2015): 625. http://dx.doi.org/10.3987/com-14-s(k)12.
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Cui, X., and C. Q. Doe. "The role of the cell cycle and cytokinesis in regulating neuroblast sublineage gene expression in the Drosophila CNS." Development 121, no. 10 (October 1, 1995): 3233–43. http://dx.doi.org/10.1242/dev.121.10.3233.
Abstract:
The precise temporal control of gene expression is critical for specifying neuronal identity in the Drosophila central nervous system (CNS). A particularly interesting class of genes are those expressed at stereotyped times during the cell lineage of identified neural precursors (neuroblasts): these are termed ‘sublineage’ genes. Although sublineage gene function is vital for CNS development, the temporal regulation of this class of genes has not been studied. Here we show that four genes (ming, even-skipped, unplugged and achaete) are expressed in specific neuroblast sublineages. We show that these neuroblasts can be identified in embryos lacking both neuroblast cytokinesis and cell cycle progression (string mutants) and in embryos lacking only neuroblast cytokinesis (pebble mutants). We find that the unplugged and achaete genes are expressed normally in string and pebble mutant embryos, indicating that temporal control is independent of neuroblast cytokinesis or counting cell cycles. In contrast, neuroblasts require cytokinesis to activate sublineage ming expression, while a single, identified neuroblast requires cell cycle progression to activate even-skipped expression. These results suggest that neuroblasts have an intrinsic gene regulatory hierarchy controlling unplugged and achaete expression, but that cell cycle- or cytokinesis-dependent mechanisms are required for ming and eve CNS expression.
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Rahman, Nayem. "Saving DBMS Resources While Running Batch Cycles in Data Warehouses." International Journal of Technology Diffusion 1, no. 2 (April 2010): 42–55. http://dx.doi.org/10.4018/jtd.2010040102.
Abstract:
In a large data warehouse, thousands of jobs run during each cycle in dozens of subject areas. Many of the data warehouse tables are quite large and they need to be refreshed at the right time, several times a day, to support strategic business decisions. To enable cycles to run more frequently and keep the data warehouse environment stable the database system’s resource utilization must be optimal. This paper discusses refreshing data warehouses using a metadata model to make sure jobs under batch cycles run on an as-needed basis. The metadata model limits execution of the stored procedures in different analytical subject areas to source data changes in the source staging subject area tables, and then implements refreshes of analytical tables for which new data has arrived from the operational databases. The load is skipped if source data has not changed. Skipping unnecessary loads via this metadata driven approach enables significant database resources savings. The resource savings statistics based on an actual production data warehouse demonstrate an excellent reduction of computing resources consumption achieved by the proposed techniques.
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Tonini, G., B. Vincenzi, E. Vasile, V. Catalano, V. Virzì, A. Fontana, S. Intagliata, G. Catalano, A. Falcone, and D. Santini. "Phase II capecitabine and gemcitabine fixed dose rate (FDR) in patients with advanced pancreatic cancer." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e15530-e15530. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15530.
Abstract:
e15530 Background: The aims of this phase II trial are to determine the activity and the safety of the new combination modality with Gemcitabine fixed dose rate (FDR) infusion and Capecitabine in patients with advanced pancreatic cancer. Methods: Patients with unresectable pancreatic cancer who had pathologically confirmed adenocarcinoma, no prior chemotherapy, ECOG PS < 2 and measurable disease were enrolled. Gemcitabine (800 mg/mq IV infused in 80 minutes on days 1 and 8) and Capecitabine (650 mg/mq orally twice daily for 14 days) were administered and repeated every 21 days. Results: 47 patients were enrolled between January 2004 and October 2008. Median age was 66 (range: 37–79), 18 female and 29 male. A total of 299 cycles were administered, median cycles for patient were 6 (range: 1–17). CR was observed in one patient (2.1 %) and 10 patients achieved PR (21.3 %) giving an overall response rate of 23.4 % in intention-to-treat population. 22 pts (46.8 %) had stable disease obtaining an overall tumour control of 70.2 %. The median time to progression was 5.2 months (95 % CI, 2.4–7.6); the median overall survival was 8.4 months (95 % CI, 5.5–20). Grade 3–4 neutropenia was observed in 29.8 % of subjects, thrombocytopenia in 6.4 %. Grade 1–2 non-hematological toxicities were asthenia (61.7 %), diarrhea (29.8%), stomatitis (29.8 %) and hand foot syndrome (2.1 %). There were no treatment-related deaths. Gemcitabine was skipped at least once/reduced in 51/10.6 % of the patients, respectively. Capecitabine was skipped at least once/reduced in 16/8 % of the patients, respectively. Conclusions: The combination of FDR Gemcitabine and Capecitabine with this modality of infusion is feaseble, safe and seems to be active. No significant financial relationships to disclose.
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Stark, Lloyd R. "Skipped reproductive cycles and extensive sporophyte abortion in the desert moss Tortula inermis correspond to unusual rainfall patterns." Canadian Journal of Botany 80, no. 5 (May 1, 2002): 533–42. http://dx.doi.org/10.1139/b02-053.
Abstract:
A phenological assessment of Tortula inermis (Brid.) Mont. populations in the Mojave Desert, Nevada, U.S.A., over a period of 4 years revealed that the sporophyte cohort initiated in early 1995 remained dormant until early 1998, by which time approximately 66% of the sporophytes had aborted. The viable sporophytes of this cohort were significantly shorter in length and had significantly less biomass than the previous cohort of sporophytes. In the intervening years 1996 and 1997, the sexual reproductive cycle was skipped altogether. The absence of sporophyte initiation in these two years was attributed to reduced winterspring rainfall. The majority of abortive sporophytes aborted in the late embryonic and seta elongation phenophases. The 1997 and 1998 summers were characterized by unusually heavy rains. Following the heavy summer rain events of 1997, sporophyte abortion in the 1995 cohort increased from 9 to 43%, and abortive sporophytes in this cohort further increased to 66% following the summer rains of 1998. Abortive sporophyte biomass averaged 49 µg or 33% of the mean biomass of the viable sporophytes in the cohort at maturity. These data suggest that the summer rain events precipitated two waves of sporophyte abortion, possibly through heavy membrane damage associated with rapid drying and high temperatures while hydrated.Key words: sporophyte abortion, bryophyte, desert, Tortula, desiccation.
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Li, Zhaoxia, Jie Tang, Diane C. Bassham, and Stephen H. Howell. "Daily temperature cycles promote alternative splicing of RNAs encoding SR45a, a splicing regulator in maize." Plant Physiology 186, no. 2 (March 10, 2021): 1318–35. http://dx.doi.org/10.1093/plphys/kiab110.
Abstract:
Abstract Elevated temperatures enhance alternative RNA splicing in maize (Zea mays) with the potential to expand the repertoire of plant responses to heat stress. Alternative RNA splicing generates multiple RNA isoforms for many maize genes, and here we observed changes in the pattern of RNA isoforms with temperature changes. Increases in maximum daily temperature elevated the frequency of the major modes of alternative splices (AS), in particular retained introns and skipped exons. The genes most frequently targeted by increased AS with temperature encode factors involved in RNA processing and plant development. Genes encoding regulators of alternative RNA splicing were themselves among the principal AS targets in maize. Under controlled environmental conditions, daily changes in temperature comparable to field conditions altered the abundance of different RNA isoforms, including the RNAs encoding the splicing regulator SR45a, a member of the SR45 gene family. We established an “in protoplast” RNA splicing assay to show that during the afternoon on simulated hot summer days, SR45a RNA isoforms were produced with the potential to encode proteins efficient in splicing model substrates. With the RNA splicing assay, we also defined the exonic splicing enhancers that the splicing-efficient SR45a forms utilize to aid in the splicing of model substrates. Hence, with rising temperatures on hot summer days, SR45a RNA isoforms in maize are produced with the capability to encode proteins with greater RNA splicing potential.
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Mobarak, Ahmed Mushfiq, and Maira Emy Reimão. "Seasonal Poverty and Seasonal Migration in Asia." Asian Development Review 37, no. 1 (March 2020): 1–42. http://dx.doi.org/10.1162/adev_a_00139.
Abstract:
Four in five poor people in the Asia and Pacific region live in rural areas. Crop cycles in agrarian areas create periods of seasonal deprivation, or preharvest “lean seasons,” when work is scarce and skipped meals become frequent. In this paper, we document this phenomenon of seasonal poverty and discuss existing formal mechanisms for coping with it. We then focus on seasonal migration from rural to urban areas as a potential coping strategy and review the evidence on the effects of encouraging seasonal migration through transport subsidies. Over the past 10 years, we have conducted a series of randomized control trials in Bangladesh and Indonesia that provided rural agricultural workers with small migration subsidies to pay for the cost of round-trip travel to nearby areas in search of work. This paper summarizes the lessons learned from this multicountry, multiyear series of seasonal migration trials, the implications of these results for spatial misallocation, urbanization, and growth, and the replicability and relevance of this and other policies encouraging domestic migration more broadly for other areas in the Asia and Pacific region.
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Santini, D., B. Vincenzi, E. Vasile, V. Catalano, V. Virzì, G. Masi, S. Intagliata, G. Catalano, A. Falcone, and G. Tonini. "Fixed dose rate (FDR) gemcitabine (G) and capecitabine (C) in patients with metastatic biliary tract cancer (BTC): Final results of phase II trial." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e15510-e15510. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15510.
Abstract:
e15510 Background: The combination of fixed dose rate (FDR) gemcitabine (C) and capecitabine (G) has been demonstrated to be well tolerated in patients with advanced cancers. To determine the activity and safety of this combination in metastatic metastatic biliary tract cancer patients, a phase II trial was conducted. Methods: Patients with unresectable BTC who had pathologically confirmed adenocarcinoma, no prior chemotherapy, ECOG PS < 2 and measurable disease were enrolled. Treatment consisted of FDR G at 800 mg/m(2) infused in 80 minutes on days 1 and 8 every 21 days with C administered orally bid in equal doses (650 mg/m2 bid) for 14 days (28 doses). Results: Between Feb 2005 and Sept 2008, 30 pts were enrolled. Median age was 67 (45–86) with 14 males. 30 pts were evaluable for response and toxicity. A total of 219 cycles were administered (median, 8; range, 2–16). One patient achieved CR and 8 pts achieved PR giving an overall response rate of 30.0% in intention-to-treat population (95% CI, 19.2–42.6%). And 11 pts (36.6%) had stable disease. The median time to progression of all patients was 7.4 months (mo) (95% CI, 3.2–19.5). The median overall survival was 15.3 mo (95% CI, 4.6–27.9). Grade 3/4 neutropenia and thrombocytopenia were noted in 13.3% and 6.6% of the pts, respectively. Grade 2/3 non-hematologic toxicities were asthenia (50.0 % of pts), diarrhea (16.6%), stomatitis (23.3%) and hand-foot syndrome (6.6%). There was no treatment-related death. Gemcitabine was skipped at least once/reduced in 20%/15% of the patients, respectively. Capecitabine was skipped at least once/reduced in 20%/25% of the patients, respectively. Conclusions: The combination of FDR gemcitabine and capecitabine in this three week cycle is safe and seems to have advantages in activity over other regimens in advanced biliary cancer. No significant financial relationships to disclose.
Dissertations / Theses on the topic "Skipped cycles":
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Hendrycks, Baptiste. "Modélisation de l'assemblage roue/essieu ferroviaire et de sa tenue en fatigue sous chargement cyclique." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILN049.
Abstract:
Cette thèse a pour objectif de proposer des modèles numériques permettant une meilleure compréhension du comportement en fatigue de l'assemblage roue-essieu ferroviaires.Un premier modèle simule l'opération de calage des roues sur les portées de l'essieu. Pour sa réalisation, une attention particulière a été portée au comportement en friction entre la roue et l'essieu ce qui a notamment permis de montrer une dépendance du facteur de frottement à la pression de contact. Aussi, la simulation met en évidence la création d'une singularité géométrique en début d'opération ayant une influence sur la distribution de contraintes dans la structure.Ensuite, un modèle permet la simulation de la sollicitation cyclique multiaxiale subie par un assemblage roue/essieu éprouvette échelle 1. Un modèle de comportement pour l'acier EA1N, utilisé pour la fabrication des essieux, a été développé afin de traduire à la fois la réponse monotone et cyclique du matériau. Le choix d'un niveau de chargement élevé a permis à ce modèle de caractériser l'influence du contact en montrant une déformation importante de la portée lorsqu'il y a ouverture.Afin d'avoir un dimensionnement en fatigue compatible avec le bureau d'étude, la méthode des sauts de cycles a été choisie afin de calculer rapidement un état mécanique stabilisé. L'utilisation de cette méthode dans un premier temps sur un assemblage roue/essieu simplifié, puis sur un cas réel montre une bonne précision des résultats malgré une dépendance au raffinement locaux et au comportement matériau développé qui peut contraindre le temps de calcul.Enfin, on s'intéresse à la durée de vie en fatigue de la structure avec l'application d'un critère de fatigue sur l'état stabilisé. On propose également une discussion à partir de trajets de chargement, notamment sur l'apparition de cisaillement alterné sur la portée de l'essieuThe objective of this thesis is to propose numerical models allowing a better understanding of the fatigue behavior of the railway wheel-axle assembly.A first model simulates the press fit operation in the assembly of a railway axle and wheel. A particular attention was paid to the friction between the wheel and the axle, which notably made it possible to show a dependence of the friction factor on the contact pressure. Also, the simulation highlights the creation of a geometric singularity at the start of the operation having an influence on the distribution of stresses in the structure.Then, a model simulates the multiaxial cyclic stress on a scale 1 test specimen wheel/axle assembly. A behavior model for the EA1N steel, used for the axles, was developed in order to be used for both monotonic and cyclic problems. This model, with a high loading level, shows a significant deformation of the wheel seat with the contact opening.The skipped cycles method was chosen in order to quickly calculate a stabilized mechanical state. The use of this method initially on a simplified wheel/axle assembly, then on a real case shows good precision of the results despite a dependence on local refinement and the developed material behavior which can constrain the calculation time.Finally, we calculate the fatigue strength of the structure with the application of a fatigue criterion. We also propose a discussion based on loading paths, in particular on the appearance of alternating shear on the wheel seat
Conference papers on the topic "Skipped cycles":
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Warner, Michael, Tenice Nangoo, Nikhil Shah, Adrian Umpleby, and Joanna Morgan. "Full-waveform inversion of cycle-skipped seismic data by frequency down-shifting." In SEG Technical Program Expanded Abstracts 2013. Society of Exploration Geophysicists, 2013. http://dx.doi.org/10.1190/segam2013-1067.1.
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Al Yaqoobi, A., and M. Warner. "Full Waveform Inversion - A Strategy to Invert Cycle-skipped 3D Onshore Seismic Data." In 75th EAGE Conference and Exhibition incorporating SPE EUROPEC 2013. Netherlands: EAGE Publications BV, 2013. http://dx.doi.org/10.3997/2214-4609.20130838.
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Paulraj, Lemuel Srinivasan, Anuroopa Varsha, Subramanya Karadi, and Devendra Kumar. "Engine Modelling with Smart Online DoE." In Symposium on International Automotive Technology. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2024. http://dx.doi.org/10.4271/2024-26-0338.
Abstract:
<div class="section abstract"><div class="htmlview paragraph">The implementation of TREM/CEV 5 emission norms on farm equipment will bring in cost pressure due to the need for exhaust after treatment systems. This cost increase needs to be reduced by bringing in more efficient and effective processes to shorten the development phase and to provide better fuel efficiencies.</div><div class="htmlview paragraph">In this work ETAS ASCMO Online DoE with Constraint Modelling (ODCM) was applied to execute smart online DoE on a new common rail diesel engine with EGR, whose exact bounds of operation was not available. A Global test plan with ASCMO Static was created without much focus on detailed constraints of engine operation, other than the full load curve. The parameters which were selected were Speed, Torque, Rail Pressure, Main Timing, EGR Valve Position, Pilot Separation and Quantity and Post Quantity and Separation. For these parameters, the safe operating bounds were not available.</div><div class="htmlview paragraph">This ASCMO Static test plan is automated and executed on engine test cell with ETAS INCAFlow. ODCM at each step delivers a next operating point to be measured on testbench and if this operating point is within the defined limits of engine operations, the point is measured or if it outside the limits, the point is skipped. At every step, ODCM uses the information generated to modify the order of remaining DoE points in which only feasible measurement are suggested and those which are not feasible are skipped.</div><div class="htmlview paragraph">The results of this work showed a 35% reduction in the total efforts. Since the model was Global, other variants were also covered with the same ASCMO Static Models without any requirements for additional test runs/measurements. Stringent cycle SFC mandates, which was not possible with earlier methods, was also realized with ODCM approach as ODCM extends the coverage range of measurements. The results also reduced the need for new engine development to meet the stringent requirements.</div></div>
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Cluever, Joseph, Thomas C. Esselman, and Sam Harvey. "Financial Optimization of a Preventive Replacement Strategy for Individual Components." In ASME 2018 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/pvp2018-84833.
Abstract:
Électricité de France (EDF) has developed the Investment Portfolio Optimal Planning (IPOP) software tool [1] to be released with the Integrated Life Cycle Management (ILCM) software tool developed by the Electric Power Research Institute (EPRI) [2]. IPOP is an extremely powerful tool that uses genetic algorithms to provide an optimal strategy for investment in spare components and preventive replacements of multiple components at multiple power plant stations across an entire fleet. A drawback of IPOP is that it requires an extensive amount of user information to run even a single component. In response, Component Optimization Analysis Tools (COATs) was developed to simplify the process of deriving an optimal strategy for purchasing spares and replacements for a single component. This paper describes a two-layer algorithm used in the replacement strategy optimization in COATs. The inner layer consists of a Monte Carlo simulation that estimates the Expected Net Present Value (ENPV) of a given replacement strategy. A strategy consists of: the age of a component at which it needs to be replaced, the age of a component at which a spare should be purchased, years left in the plant at which to skip a scheduled replacement, and the end of life at which the scheduled replacement is skipped; and the years left in the plant at which no more spares are purchased. The Monte Carlo analysis uses these four strategy inputs with component costs, acquisition times, and reliability curves with plant downtime costs to calculate an ENPV for that strategy. The outer layer of the algorithm is an optimization layer that can use either Bayesian optimization or genetic algorithms to maximize the ENPV. These optimization algorithms are routinely available in various software packages and effectively treat the ENPV Monte Carlo as a black box function. An efficiency comparison is given between the two optimization algorithms to demonstrate under which conditions each algorithm out performs the other.