Dissertations / Theses: 'Skin'

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JESUS, CRISTIANE FATIMA DIAS DE. "SKIN DISORDERS: ONE SKIN FOR TWO?" PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2004. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5226@1.

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COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
A pele tem uma importância fundamental na nossa constituição psíquica. Através dos primeiros contatos de pele com a mãe ou ambiente maternante o bebê começa a formar as mais primitivas impressões acerca do corpo que lhe pertence e do mundo que o rodeia. Este estudo pretende mostrar que as afecções de pele refletem um desejo de retorno ou permanência no estado de indiferenciação com a mãe. Deste modo, parte-se do princípio que distorções no elo mãe-filho desde cedo não permitem ao mesmo vivenciar com naturalidade seu trajeto rumo à independência, nos termos de Winnicott, ou em direção à individuação, de acordo com Mahler. A falta de um ambiente bom o bastante dificulta a aquisição de uma experiência subjetiva de corpo. Por outro lado, abordam- se também os pressupostos da Escola de Psicossomática de Paris, segundo a qual, os processos que levam à vulnerabilidade psicossomática também estariam relacionados à falhas na estruturação desta ligação, resultando na insuficiência e/ ou desorganização das funções psíquicas. Portanto, com este objetivo pretende-se mostrar que as afecções de pele refletem uma falha nos processos de delimitação das fronteiras do corpo pela falta ou inadequação do investimento materno nos primeiros anos de vida, dificultando a experiência de unidade e coesão de seus processos internos e externos. Na parte final, procede-se à discussão de um caso clínico à luz das teorias anteriormente mencionadas.
The skin is of basic importance to our psychic constitution. Through the first skin contacts with the mother or mothering environment the baby starts to form the most primitive impressions concerning the body that belongs to him/her as well as the world that surrounds it. This study intends to show that skin disorders reflect the desire of a return or permanence in the state of indiferenciation with the mother. In this way, based on distortions in the early mother-baby link, the child is not allowed to naturally live his passage towards independence, as per Winnicott, or towards individuation, according to Mahler. The lack of a good enough environment makes the acquisition of a subjective body experience difficult. On the other hand, principles of the school of psychoanalytic psychosomatics of Paris were used, according to which processes that lead to the psychosomatic vulnerability would also be related to imperfections in structuring this relationship, which would result in an insufficient and/or a disorganization of the psychic functions. Therefore with this objective in mind, it was intended to show that skin disorders reflect a failure in the process of delimitation of the body limits due to the lack or inadequate maternal investments in the first years of life, hindering an experience of oneness and cohesion of internal and external processes. In the final part of the dissertation a clinical case is discussed according to the theoretical background covered in this work.

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Pan, Wei. "Skin image processing and skin characterizations." Thesis, London South Bank University, 2017. http://researchopen.lsbu.ac.uk/1847/.

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The skin hydration and skin Trans epidermal water loss (TEWL) are of great importance in many skin research areas, such as dermatology, clinical analysis, pharmacology and cosmetic science etc. However, to measure them is not easy. Over the year , our research group has developed three novel technologies for such measurement : Opto Thermal Transient Emission Radiometry (OTTER), AquaFlux and capacitive contact imaging based on the Fingerprint sensor. The aim of this research is to develop new skin image processing and data analysis techniques for capacitive contact images, as well as digital colour images, and to develop new methodologies for skin characterization by using the three technologies. For skin image processing, a new GUI based MATLAB programme has been developed, which can be used for extracting and analysing the images from the result files created by the measurement instruments. The programme implement the skin image processing techniques such as image enhancement (i.e. brightness equalization, extraction of skin texture, hair removal), image stitching, image matching and skin surface 3D profiling etc. Another image processing programme based on OpenCV has also been developed, which is more suitable for real time video processing, including contour detection, texture extraction and face detection etc. For the skin characterization, several experiments are conducted: skin over hydration experiments; kin damage assessment including intensive washing, SLS irritations, and tape stripping; dermabrasion experiments; soap drying effect assessment. These experiments provide better understandings of the technologies. The occlusion effects in capacitive images shows good potential for skin damage assessment, as it can not only reflect the scale of damage, but also the types of damage.

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George, Maryan. "Adrenaline releases level on skin-to skin touches." Thesis, Högskolan i Skövde, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19090.

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Human pleasant touches promote feelings of security, supportiveness, and wellbeing. Conversely, human unpleasant touches promote the body for either “fight or flight” or “short term acute stress” during emergencies, feeling of stress or danger. The promoted stress response is released from the hypothalamus by the sympathetic nerve system further to the spinal cord to reach the signals to the adrenal medulla, where stress hormones adrenaline is released. Adrenaline, which is characterized by a mimic sympathetic nerve system, interacts with α and β receptors on different organs. The aim for this study was to investigate whether the stroker (partner/stranger) touch effects on adrenaline hormone releases. The null hypothesis for this study entails a significant adrenaline reduction in partners’ touches compared with strangers’ touches. Indirect competitive ELISA method was used, and concentration data of a total of sixteen participants was obtained. Whitney-U test was carried out to compare group differences within stroker (stranger/partner) touches and adrenaline releasing level. In addition, correlation in adrenaline with noradrenaline and oxytocin hormones was obtained using Spearman’s correlation test. The significant p-value 0.05 was conducted. The result of this study showed no differences between stroker (partner/stranger) associated with adrenaline hormone release. Correlation between partner maximum (max) concentration data for both oxytocin and adrenaline had significant differences. However, max variables for adrenaline and noradrenaline within stroker did not show significant differences. The conclusion of this study is that the gentle touch stimulus used in this study was not enough to detect stress hormone in adrenaline.

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Lutz, Monica Ann. "Skin-to-Skin Bonding and Cesarean Section Delivery." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1368115929.

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Meade, Celia. "Skin boat." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0002/MQ34931.pdf.

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Orth, Margaret A. (Margaret Ann) 1964. "Skin flicks." Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/69305.

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Thesis (M.S.V.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1993.
Includes bibliographical references (leaves 100-102).
The written and artistic part of this thesis are both separated into the two categories of "SKIN" and "FLICKS". The Artistic part of my thesis consists of five artificial skins made on my body, and a series of video tapes of the performance of me making those skins. A number of devices have been built into these skins to provide my body and self with messages and stimuli from the outside. Through the action of rebuilding myself and exposing some of the elements that form me I am physically and materially exploring the nature of subjectivity and constructed self in our society. The video tapes of the performance are representations of both the act of rebuilding myself and my body. They are reflections and criticism of the way women are taught to see and present themselves in our culture. They are the product of my perspective and of a culture of surveillance, pornography and empirical observation. The written part of my thesis deals with the sanctity of making through the two categories of "SKIN" and "FLICKS". The "SKIN" part consists of analysis of the physical properties of skin, its ability to be imitated and its role in material making. It relates our attempt to recreate ourselves to the "rebuilding" of the natural world. It explores through the physical material skin, the value and purpose of material making. The "FLICKS" section of my document explores and examines some of the history of the representation of skin in visual art. This history includes some classical works, Renaissance works, nineteenth century nudes and contemporary films. It also questions the ability of images to represent anything other than skin through a discussion of iconoclasm and its relation to some contemporary critical practices in the arts.
by Margaret Orth.
M.S.V.S.

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Pugach, N. V., and S. S. Stryzhak. "The skin." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/40573.

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The skin is our body‘s envelope, acting both as a protection and as a means of interacting with the outside world. Its structure is complex and divided into three layers: the epidermis, the outermost layer, the dermis, and the deepest, the hypodermis, each of which fulfils precise functions.

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Gentry, Retha D., Lisa Ousley, and Candice N. Short. "Skin Examination." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7148.

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Bielak, Britta. "Second Skin." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3583.

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Reason for writing. The space of confusion and possibility where the practices of art and design collide seems to be in a constant amoebic state. This place of shared influence and growth seems to pervade not only the intersection of these two disciplines, but within interior design, the intersection of people and space. How can the boundaries between an interior space and it’s inhabitants be as richly embedded with tension and opportunity as the edges where art and design meet? Like art and design, how can a space and it’s visitors interact to affect one another? Problem + Methodology: This project explores these questions in a context mindful of their origin: The Virginia Museum of Fine Arts. The design proposal of inserting a fashion wing into the VMFA’s existing context evolves from research and process work across art, design, and architecture, from the scale of the building to the scale of a seat. Results + Implications: The challenge of creating public space that can be just as responsive to and influential over it’s inhabitants as private space seems resolved through the navigation of movement and moment. Finding value in an unscripted discovery of a space and the ownership of private experiences, offers a way to feel engaged with and connected to a space that doesn’t rely on object ownership or territorial comfort. This solution does rely, however, on inhabitants capable of being present and responsive to their environment, allowing other visitor’s interactions with the space and their individual path through the exhibits to affect their perceptions of and connectedness with the design.

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Williams, Court. "Sensitive skin." Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28932.

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The work being considered for examination will be my gallery installation Affliction. Consisting of approximately six hundred digitally printed and hand constructed three dimensional models, it will be installed on the gallery floor as a part of the Postgraduate Degree show at Sydney College of the Arts (Tuesday December 9th through to Wednesday December 17th). My masters project explores the isolation and dislocation experienced in the urban environment and situates un-commissioned street art as a construct that potentially generates modes of plurality through immediate encounter, collaboration and intervention. My work explores the inter-activity of street art. This is done through a reading of Nicolas Bourriaud’s Relational Aesthetics - a theory of art that takes as its theoretical horizon the realm of human inter-actions in social spaces. 1 demonstrate the inter-activity of street art through a discussion of my work as well as the work of three other street artists. In doing so, 1 also draw attention to the virtual characteristics of the anonymous urban environment by locating street art as a virtual representation of the art world, the street artist as an avatar and the city surface as an online blog.

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Newall, Tracy (Nelly). "Skin tear prevention: what Is “usual” skin moisturising practice?" Thesis, Curtin University, 2014. http://hdl.handle.net/20.500.11937/2248.

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This study was an adjunct to a randomised controlled trial (RCT) to test whether skin moisturising reduced the incidence of skin tear development.Staff surveys and interviews identified that there was ad hoc moisturising practice pre-intervention while post-intervention “usual”’ practice matched the intervention protocol at just the intervention sites. This finding therefore allowed the RCT to conclude that the lower skin tear incidence found in the intervention sites could be attributed to the moisturising protocol.

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Larocque, Catherine. "Are We on the Same Page About Skin-to-Skin Care? A Descriptive Correlational Study Exploring Skin-to-Skin Care for Postoperative NICU Infants." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41079.

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Family-centered care (FCC) is considered the gold standard for care delivery in the Neonatal Intensive Care Unit (NICU). However, there are challenges with the implementation of FCC in practice and there is limited literature about how to tailor this approach for specialized NICU populations. To explore FCC for surgical neonates in the NICU, the concept was explored using Roger’s evolutionary concept analysis. Results illustrate that FCC in the NICU is a philosophy or care, rather than a set of interventions. The subsequent cross-sectional descriptive exploratory study showed that the surgical infants in our sample (n=11) received a limited amount of skin-to-skin care (median 0 mins/day) and parents reported challenges to being involved in their infant’s care. This thesis supports the challenges with the implementation of FCC in practice and both the need to consider multiple perspectives and the need for broader systemic change in order to support a FCC philosophy.

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Miller, Melina Rose, and Melina Rose Miller. "Best practice guidelines for skin-to-skin contact following birth." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626827.

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The purpose of this thesis was to develop an educational pamphlet with best practice guidelines for expectant parents and nurses about skin-to-skin contact. The research conducted for this thesis focused on the benefits of skin-to-skin contact for mothers, pre-term infants, and term infants following both vaginal and cesarean deliveries. Skin-to-skin contact has been referred to as the optimal form of care for a newborn (Erlandsson, Dsilna, Fagerberg, & Christensson, 2007). When skin-to-skin contact does not occur following birth, the most common reasons are lack of education among parents and lack of collaboration of the healthcare team (Zwedberg, Blomquist, & Sigestad, 2013). Some of the benefits skin-to-skin contact has to offer for mothers is as a reduction in anxiety, depression, and postpartum hemorrhage (Moore, Anderson, & Bergmen, 2009). Some of the benefits of skin-to-skin contact for infants is a reduction in sepsis, infection, and hypothermia. Pre-term infants are also more likely to breastfeed and gain more weight daily if they engage in skin-to-skin contact (Conde-Agudelo & Díaz-Rossello, 2016). Implementing an educational pamphlet within the setting of a childbirth class would provide expecting parents with evidence-based information on the benefits and feasibility of skin-to-skin contact.

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Bertaux, Emilie. "Mechanical friction between skin and sport textiles yielding skin irritation." Valenciennes, 2008. https://ged.uphf.fr/nuxeo/site/esupversions/808ac959-0f92-473f-b3bb-2a0acab897a8.

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Afin d'améliorer le confort des coureurs en réduisant l'irritation de la peau due au phénomène de friction mécanique, le Textile Friction Analyzer a été récemment développé au sein de l'Empa. Cet appareillage permet de caractériser la friction peau-textile (T-shirt et chaussette) en utilisant une peau artificielle (skin model) et ceci en simulant les conditions de contacts durant la pratique sportive. Différentes peaux artificielles ont été développées afin de reproduire les propriétés frictionnelles de la peau du pied ou du téton humain. Les paramètres de tests comme la force de contact, la vitesse relative et le nombre de cycles propres à chaque textile et type d'activité sportive ont été définis par la réalisation d'études biomécaniques. Une autre étape importante a consisté au développement d'un système de chauffage pour la peau artificielle et la simulation de la sudation. Ces conditions spécifiques permettent donc la simulation de la friction mécanique entre la peau et les vêtements sportifs du type chaussette et T-shirt proche de la réalité. Le Textile Friction Analyzer a été utilisé pour étudier l'influence des fibres et des constructions sur la friction. De plus, des tests avec sujets ont été réalisé afin d'analyser les relations entre les paramètres textiles, physiologiques et sensoriels basés sur le confort durant la pratique sportive. Les résultats obtenus représentent une avancée dans la compréhension de l'influence des différents paramètres sur l'irritation de la peau durant l'activité sportive et peuvent être utilisés ultérieurement pour le développement de vêtements sportifs à faible coefficient de friction afin d'améliorer le confort des sportifs
In order to improve runners' comfort by reducing skin irritation due to mechanical friction, a Textile Friction Analyzer was previously developed at Empa. This measurement device characterizes the friction of socks and T-shirts against mechanical skin models under cyclic contact conditions which are typical for sport activities. Different skin models were developed in order to simulate the frictional properties of human foot skin or the human nipple. Testing parameters such as contact pressure, sliding velocity and number of friction cycles depend on the specific textile and sport application and were defined on the basis of biomechanical studies using pressure sensors and high speed cameras. Another important step was to develop a heating system for the skin models used on the Textile Friction Analyzer and to simulate the sweating of the human body. The specified testing conditions allow simulating cyclic friction contacts between sport textiles such as socks and T-shirts and skin close to reality. The Textile Friction Analyzer was used to study the influence of fibers and constructions on friction. Moreover, subjective tests were carried out to investigate the relationships between textile, physiological and sensorial parameters on comfort during sport activity using principal component analysis and decision trees. The results of this research represent a step towards a better understanding of the influence of different parameters on skin manifestations during sport activity which can be used for developing low friction sport textiles to increase sportsmen's comfort

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Karsten, Aletta Elizabeth. "The effect of skin phototype on laser propagation through skin." Thesis, University of Pretoria, 2012. http://hdl.handle.net/2263/24272.

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The use of lasers for diagnosis and treatment in medical and cosmetic applications is increasing worldwide. Not all of these modalities are superficial and many require laser light to penetrate some distance into the tissue or skin to reach the treatment site. Human skin is highly scattering for light in the visible and near infrared wavelength regions, with a consequent reduction of the fluence rate. Melanin, which occurs in the epidermis of the skin, acts as an absorber in these wavelength regions and further reduces the fluence rate of light that penetrates through the epidermis to a treatment site. In vivo fluence rate measurements are not viable, but validated and calibrated computer models may play a role in predicting the fluence rate reaching the treatment site. A layered planar computer model to predict laser fluence rate at some depth into skin was developed in a commercial raytracing environment (ASAP). The model describes the properties of various skin layers and accounts for both the absorption and scattering taking place in the skin. The model was validated with optical measurements on skin-simulating phantoms in both reflectance and transmission configurations. It was shown that a planar epidermal/dermal interface is adequate for simulation purposes. In the near infrared wavelength region (676 nm), melanin (consisting of eumelanin and pheomelanin) is the major absorber of light in the epidermis. The epidermal absorption coefficient is one of the required input parameters for the computer model. The range of absorption coefficients expected for typical South African skin phototypes (ranging from photo-sensitive light skin, phototype I on the Fitzpatrick scale, to the photo-insensitive darker skin phototype V) was not available. Non-invasive diffuse reflectance spectroscopy measurements were done on 30 volunteers to establish the expected range of absorption coefficients. In the analysis it became apparent that the contributions of the eumelanin and pheomelanin must be accounted for separately, specifically for the Asian volunteers. This is a new concept that was introduced in the diffuse reflectance probe analysis. These absorption coefficient measurements were the first to be done on the expected range of skin phototypes for the South African population. Other authors dealing with diffuse reflectance probe analysis only account for the dominant eumelanin. Both the epidermal absorption coefficient and thickness are important in the prediction of the fluence rate loss. The computer model was used to evaluate the effect of the epidermal absorption coefficient (a parameter dictated by an individual’s skin phototype) and the epidermal thickness on the fluence rate loss through the skin. The epidermal absorption is strongly wavelength dependent with the higher absorption at the shorter wavelengths. In the computer model a longer wavelength of 676 nm (typical for a photodynamic treatment (PDT) of cancer) was used. For the darker skin phototypes (V) only about 30% of the initial laser fluence rate reached a depth of 200 ìm into the skin (just into the dermis). For the PDT application, results from the computer model indicated that treatment times need to be increased by as much as 50% for very dark skin phototypes when compared to that of very light phototypes.
Thesis (PhD)--University of Pretoria, 2012.
Physics
unrestricted

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Eriksson, Sofia. "Beyond the skin." Thesis, Konstfack, Ädellab, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:konstfack:diva-6409.

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This paper presents an investigation in stages of transformation between body and ornament to show upon their fluid relationship and their role for the creation of human identity. I see the act of adorning the body as an act of desire, in which we take part to become something more elevated than our original state of being. I use my background as a jeweller and the body as the territory for investigating these acts of transformation. Through material explorations I examine how we mirror ourselves in the things we make and how we reinvent our bodies through making. I compare the role of the maker with the scientist and discuss the increased interest in the body and its relation to a more and more virtual reality. I make links between ancient body modifications and human enhancement within new technology and throughout the paper I discuss my work in relation to other artists work and theorists relating to visual practices.

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McCaffrey, Clare Alexis. "Inhabiting the Skin." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/35220.

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Appreciation of the natural light, air, and scenery outside the built interior environment spurs the architect's desire to "bring the outside in". (Lately, floor-to-ceiling glazing is the most popular way of doing this.) Appreciation of what can be found "in the wall" also inspires the architect. Neither inside nor outside, being "in the wall" offers unique sensory experiences. Historically, the thick masonry walls of public buildings provided spaces (such as the arched vestibule of a library) within the walls' openings where people could gather to talk or wait out the rain. Another example of space within walls is the window seat, which is the architect's response to many peoples' desire to curl up inside a window to read a book or to watch what's going on outside. Modern materials and technologies have allowed us to build buildings taller and lighter than ever before but they also have led us to cease creating those special spaces, neither inside nor outside, that protect people from the elements without entirely cutting them off from them. It is this third space, neither inside nor outside, that I seek to reclaim in this thesis project. I hope to return to people space of fresh air, indirect, natural light, sense of protection, and openness; a place where stories are traded, secrets are whispered, and stars are wished on. With this project, I seek to develop a third space.
Master of Architecture

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Taylor, Justine Michelle. "The Third Skin." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/9514.

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The Third Skin project consists of two parts: a research paper that critically examines the convergence of theories of dress and the Japanese all over Body Tattoo (JAOBT) as practices and markers of identity or embodied subjectivity; and a creative body of work consisting of an installation comprised of four garments that feature motifs of carnivorous plants as tattoo prints to reference the femme fatale and women’s sexuality in the popular imagination. By drawing on contemporary popular imagination and nineteenth century Darwinian parallels between insectivorous plants and the suppressed yet purportedly voracious sexual appetite of Victorian women, the studio work visually comments on the control of women’s sexuality in the West. The depictions of carnivorous plants serve as feminist motifs because of their association with a voracious sexuality that cannot be contained. Coupled with discordant colour ways, the motifs suggest perversity and transgression that are allied to queer subjectivity. The prints are stylistic adaptations from the art of the Edo period of Japan arranged on the body and digitally printed on t-shirts in the same saddle shoulder shape as the JAOBT; they feature a replicated graphic background or ‘wind bars’. Examining the body as the key component and by situating the JAOBT in a historical and contemporary context, the research paper investigates how dress and tattooing serves to inscribe the body with meaning, and how tattooing uses a literal method of inscription to achieve the same result. Keeping this in mind, The Third Skin examines and establishes the areas of overlap as they pertain to fashion, identity, art and the tattooed body.

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Taylor, Anne. "Knowledge and reported behaviour of South Australian adults regarding sun protection /." Adelaide : University of Adelaide, Dept. of Community Medicine, 1996. http://web4.library.adelaide.edu.au/theses/09MPM/09mpmt238.pdf.

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Njoku, Francisca. "Translating Evidence of Skin-to-Skin and Rooming-in to Practice." Thesis, Walden University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10621910.

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The old practice of separating the mother-baby-dyad was without measurable benefits to mothers or their infants. Evidence has shown that skin-to-skin care (SSC) prevents hypothermia and hypoglycemia, decreases crying during painful procedures in newborns, and reduces maternal anxiety, stress, and postpartum depression. Rooming-in care (RIC) has been linked to an increase in the rate of breastfeeding and mother-infant interaction, as well as a decrease in the infant morbidity rate. This project assessed the effect of an educational intervention to increase rates of SSC and RIC in an obstetric unit, in addition to measuring nurses’ attitudes and barriers in relation to SSC and RIC. The obstetric nurses received educational content related to SSC and RIC based on Kotter’s model of change. A pre and postintervention evaluation showed a significant increase in the rates of SSC and RIC from pretest of 10%, to posttest of 96%; and RIC from pretest of 10% to posttest of 92%. Using a Wilcoxon test, a significant difference was found from pretest to posttest for every subscale score of the Mother-Newborn Skin-to-Skin Contact Questionnaire and Nurse Attitudes and Barriers to nonseparation Scale (p < 0.001), with the exception of belief about obstacles for SSC, which yielded a nonsignificant change (p = 0.57). This DNP project led to changes in the organization’s culture, including the closure of the well-baby nursery. This project promoted social change across the organization, in that the team health care providers delivered evidence-based, standardized, unbiased, and family-centered care to the mother-baby dyad.

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Kerr, Peter Joseph. "A study of skin homeostasis and skin tumorigenesis using transgenic mice." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366197.

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Marecki, Andrew T. (Andrew Thomas). "Skin strain analysis software for the study of human skin deformation." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/74986.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 58).
Skin strain studies have never been conducted in a precise and automated fashion. Previous in vivo strain investigations have been labor intensive and the data resolution was extremely limited such that their results were largely qualitative. There is a need for a better system to collect, compute, and output strain measurements of the skin in vivo for the purpose of designing better mechanical interfaces with the body. Interfaces that have the same strain behavior as human skin can minimize shear forces and discomfort for the user. One particular application is improving the design of prosthetic liners for amputees, creating a second skin sleeve that provides support without hindering movement. A custom approach offering high resolution marker density, automatic point tracking and correspondences, and computational transparency is presented in this thesis. The entire computational toolbox is presented, which takes in high resolution digital photographs, tracks points on the surface of the body, corresponds points between body poses, computes a series of strain measures, and graphically displays these data. The results of studies of a full bodied human knee and a transtibial amputee's residual limb are presented here as well.
by Andrew T. Marecki.
S.M.

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Hamidi, Maryam. "MICROBIOME OF PRETERM INFANTFROM SKIN-TO-SKIN CARE TO ANTIBIOTIC STEWARDSHIP." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625851422254064.

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Horst, Joanna Horst. "Effect of Multiple Skin-to-Skin Experiences on Exclusive Breastfeeding Rates." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3612.

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Breastmilk feeding at birth demonstrates short- and long-term medical and neurodevelopmental advantages. Infants who are exclusively breastfed demonstrate less nausea, vomiting, and diarrhea, and they experience less upper respiratory and ear infections than do infants who are not breastfed. One strategy that supports breastfeeding initiation is providing skin-to-skin contact (STS) with mothers and newborns immediately upon birth. The purpose of this project was to evaluate the impact of a second session of STS on the postpartum unit on exclusive breastfeeding rates at discharge. A retrospective comparison design using Swanson's caring model was used to guide the evaluation study that examined and compared the rate of exclusive breastfeeding before and after the new model of care was implemented. The historical controls rate included all delivered women in a 3-month period who expressed a desire to exclusively breastfeed and who had one session of STS. In this group, the exclusive breastfeeding rates were 46% at discharge. After the practice change, the 75 women who expressed a desire to exclusively breastfeed and who had the second session of STS demonstrated exclusive breastfeeding rates of 72% at discharge. The increased rate of exclusive breastfeeding and the promotion of newborn health represent a major contribution to positive social change through the introduction of a second session of STS. The extension of the STS practice from only the immediate postdelivery setting to the postpartum setting provides a contribution to nursing practice that can be shared in any birth or similar practice setting.

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Berzina, Zane. "Skin stories charting and mapping the skin research using analogies of human skin tissue in relation to ma textile pratice." Online version, 2000. http://ethos.bl.uk/OrderDetails.do?did=1&uin=uk.bl.ethos.412114.

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Bodén, Ida. "Near infrared and skin impedance spectroscopic in vivo measurements on human skin : development of a diagnostic tool for skin cancer." Doctoral thesis, Umeå universitet, Kirurgi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50605.

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Every year approximately 2800 Swedes are diagnosed with malignant melanoma, the form of cancer that is most rapidly increasing in incidence in the Western world. The earlier we can identify and diagnose a malignant melanoma, the better is the prognosis. In Sweden, 155 000 benign naevi, harmless skin tumours or moles, are surgically excised each year, many of them because melanoma cannot be dismissed by non-invasive methods. The excisions result in substantial medical costs and cause unrest and suffering of the individual patient. For untrained physicians, it is often difficult to make an accurate diagnosis of melanoma, thus a tool that could help to strengthen the diagnosis of suspected melanomas would be highly valuable. This thesis describes the development and assessment of a non-invasive method for early skin cancer detection. Using near infrared (NIR) and skin impedance spectroscopy, healthy and diseased skin of various subjects was examined to develop a new instrument for detecting malignant melanoma. Due to the complex nature of skin and the numerous variables involved, the spectroscopic data were analysed multivariately using Principal Component Analysis (PCA) and partial leas square discriminant analysis (PLS-DA). The reproducibility of the measurements was determined by calculating Scatter Values (SVs), and the significance of separations between overlapping groups in score plots was determined by calculating intra-model distances. The studies indicate that combining skin impedance and NIR spectroscopy measurements adds value, therefore a new probe-head for simultaneous NIR and skin impedance measurements was introduced. Using both spectroscopic techniques it was possible to separate healthy skin at one body location from healthy skin at another location due to the differences in skin characteristics at various body locations. In addition, statistically significant differences between overlapping groups of both age and gender in score plots were detected. However, the differences in skin characteristics at different body locations had stronger effects on the measurements than both age and gender. Intake of coffee and alcohol prior to measurement did not significantly influence the outcome data. Measurements on dysplastic naevi were significantly separated in a score plot and the influence of diseased skin was stronger than that of body location. This was confirmed in a study where measurements were performed on 12 malignant melanomas, 19 dysplastic naevi and 19 benign naevi. The malignant melanomas were significantly separated from both dysplastic naevi and benign naevi. Overall, the presented findings show that the instrument we have developed provides fast, reproducible measurements, capable of distinguishing malignant melanoma from dysplastic naevi and benign naevi non-invasively with 83% sensitivity and 95% specificity. Thus, the results are highly promising and the instrument appears to have high potential diagnostic utility.

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Berzina, Zane. "Skin stories : charting and mapping the skin : research using analogies of human skin tissue in relation to my textile practice." Thesis, University of the Arts London, 2004. http://ualresearchonline.arts.ac.uk/2297/.

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The practice based research "Skin stories: charting and mapping the skin" deals with issues across the fields of art, design, technology, biology and material science. In an attempt to bridge the gap between aesthetics and technology by investigating the potential of new and industrial materials, the epidermis is used as a metaphor for creating innovative textile surfaces which behave, look or feel like skin. As a result of theoretical enquiry and practical experiments, interactive design solutions have been developed to a prototype stage for possible application in domestic environments and public spaces as well as for integration into body related design concepts. The development of such functional and interactive textile membranes will hopefully enable individuals to experience a polysensual and responsive environment and it is this aspect which is considered to be an original contribution to knowledge in the textiles field. The aim of this written thesis is not only to illustrate the journeys and investigations made along the way and to demonstrate the outcome of the research, but also to situate the practical work in its cultural, critical and technological context. This thesis is accompanied by an interactive CD-ROM which is a visual representation of my 'research map' and holds a record of the practical work carried out during the research project. The ideas of the project "Skin stories: charting and mapping the skin" have been developed and tested during a 3-year research programme towards a Ph. D. at The London College of Fashion, University of the Arts London.

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Sivertsson, Åsa. "Detection and analysis of genetic alterations in normal skin and skin tumours." Doctoral thesis, KTH, Biotechnology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3432.

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The investigation of genetic alterations in cancer-relatedgenes is useful for research, prognostic and therapeuticpurposes. However, the genetic heterogeneity that often occursduring tumour progression can make correct analysischallenging. The objective of this work has been to develop,evaluate and apply techniques that are sufficiently sensitiveand specific to detect and analyse genetic alterations in skintumours as well as in normal skin.

Initially, a method based on laser-assisted microdissectionin combination with conventional dideoxy sequencing wasdeveloped and evaluated for the analysis of the p53 tumoursuppressor gene in small tissue samples. This method was shownto facilitate the analysis of single somatic cells fromhistologic tissue sections. In two subsequent studies themethod was used to analyse single cells to investigate theeffects of ultraviolet (UV) light on normal skin. Single p53immunoreactive and nonimmunoreactive cells from differentlayers of sunexposed skin, as well as skin protected fromexposure, were analysed for mutations in the p53 gene. Theresults revealed the structure of a clandestine p53 clone andprovided new insight into the possible events involved innormal differentiation by suggesting a role for allele dropout.The mutational effect of physiological doses of ultravioletlight A (UVA) on normal skin was then investigated by analysingthe p53 gene status in single immunoreactive cells at differenttime-points. Strong indications were found that UVA (even atlow doses) is indeed a mutagen and that its role should not bedisregarded in skin carcinogenesis.

After slight modifications, the p53 mutation analysisstrategy was thenused to complement an x-chromosomeinactivation assay for investigation of basal cell cancer (BCC)clonality. The conclusion was that although the majority ofBCCs are of monoclonal origin, an occasional tumour withapparently polyclonal origin exists. Finally, apyrosequencing-based mutation detection method was developedand evaluated for detection of hot-spot mutations in the N-rasgene of malignant melanoma. More than 80 melanoma metastasissamples were analysed by the standard approach of single strandconformation polymorphism analysis (SSCP)/DNA sequencing and bythis pyrosequencing strategy. Pyrosequencing was found to be agood alternative to SSCP/DNA sequencing and showed equivalentreproducibility and sensitivity in addition to being a simpleand rapid technique.

Keywords:single cell, DNA sequencing, p53, mutation,UV, BCC, pyrosequencing, malignant melanoma, N-ras

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Gregori, Pla Clara. "Biophysical propertiesof Skin PerfusionPressure : Study of the mechanical pressure on the skin." Thesis, KTH, Fysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-123812.

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Harrison, Caroline Anne. "'In vitro' use of tissue-engineered skin to investigate skin graft contraction." Thesis, University of Sheffield, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427225.

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Walonski, Christopher. "Skin Deep: Body Modification and Agentic Identities Among Women with Skin Conditions." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3906.

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This study explores processes of identity construction among women who have skin conditions and body modifications. Analyzing seven semi-structured qualitative interviews, the author examines how individuals affected by skin conditions employ body modification practices to organize their identities and promote feelings of agency across both personal and social domains. Engaging a Bakhtinian dialogic lens, the author argues that body modification may operate as a de-stigmatization strategy that supports individuals with skin conditions in cultivating a sense of self-determination and bodily sovereignty. Shaped by grounded theory, this study’s findings trace relationships between body modification and the development of agentic identities among women with skin conditions. Confronted by medical, physical, and social disenfranchisement, women affected by skin conditions may implement body modification practices to navigate treatment, incorporate their conditions, and negotiate their relationships. The author additionally suggests implications for the application of body modification practices as somatic therapeutic modalities.

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Almutairi, Wedad Matar. "The Role of Skin-to-Skin Contact and Breastfeeding on Postpartum Hemorrhage." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1492689214882551.

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Teelucksingh, S. "Glucocorticoids and the skin." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/27520.

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Glucocorticoids are the most effective anti-inflammatory agents currently available, but a variety of adverse effects limit their clinical usefulness. This work explores further two facets of the interaction between glucocorticoids and the skin, with the aim of identifying means of reducing glucocorticoid toxicity. (a) Metabolism of glucocorticoid by skin: Human skin is active in the terminal metabolism of cortisol to cortisone, but the biological implications of this process in skin are uncertain. Because there are technical difficulties in dealing with human skin, an animal model, the nude mouse, has been evaluated for its suitability to the study of the metabolism of corticosterone to 11β-dehydrocorticosterone (the homologous reaction in rodents of cortisol to cortisone conversion in man); a process mediated by 11β-hydroxysteroid dehydrogenase. In this model, skin 11β-hydroxysteroid dehydrogenase had an apparent Km for corticosterone of 37 uM. Skin 11β-hydroxysteroid dehydrogenase was up-regulated, in-vivo, by active glucocorticoids and was NADP dependent. By comparison, kidney 11β-hydroxysteroid dehydrogenase had a higher apparent Km (120 uM) for corticosterone, used NAD and NADP with equal facility and was not regulated in-vivo by glucocorticoids. These data suggest that the skin may possess an isoform distinct from that of the kidney. (b) Skin vasoconstrictor response (blanching) to topical glucocorticoids: Glucocorticoids applied topically to human skin produce vasoconstriction in dermal vessels, the degree of which correlates closely with the potency and clinical efficacy of these compounds. Although previous works had noted heterogeneity in blanching responses to glucocorticoids, this was never systematically studied. In qualitative studies, it was shown that skin blanching was inducible by RU-28362, a specific glucocorticoid receptor (type II) agonist and blocked by RU-38486, a glucocorticoid antagonist.

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Andrews, S. G. "Skin cancer image recognition." Thesis, Lancaster University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421835.

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Greenaway, Ruth Elizabeth. "Psychorheology of skin cream." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/13622/.

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The relationship between physical and sensory properties of 40 model skin creams was investigated. Creams were formulated according to an experimental design to ensure that a wide range of textural properties could be produced from a minimal number of ingredients. The core project study comprised of objective sensory profiling of model skin creams (QDA, Quantitative Descriptive Analysis) and the physical characterisation of the textural and flow properties relevant to the use of skin creams (rheology, texture analysis and force plate analysis). Sensory attributes related to initial skin cream application procedures (firmness, thickness, resistance, spreadability, stickiness and slipperiness) were highly correlated to rheological and texture analysis parameters. Attributes related to application procedures involving a time factor and absorption of cream into the skin (drying, dragging, final greasiness and absorption) were found to be correlated to parameters from force plate analysis. A consumer study was also conducted based on a subset of the model skin creams to identify properties of skin creams that are liked by the naïve consumer. Cluster analysis and external preference mapping identified groups of consumers with different types of liking behaviour. The firmness and thickness of the samples were found to be important regarding consumer liking. Models were generated to predict the sensory properties of creams from the physical parameters. Rheological parameters (G′ at 100 % strain and logG′′ at 100 % strain) produced the most robust models that could predict firmness, thickness, resistance, spreadability and slipperiness. Models predicting attributes involving absorption of cream into the skin were less robust, these involved force plate analysis parameters.

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Khan, Z. U. "Dimethylsulphoxide and skin permeation." Thesis, Cardiff University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383119.

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Greig, Aina Vibeke Hiller. "Purinergic signalling in skin." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407987.

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Pollard, Frederick. "Sensitive skin for robotics." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558848.

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This thesis explores two novel ways of reducing the data complexity of tactile sensing. The thesis begins by examining the state-of-the art in tactile sensing, not only examining the sensor construction and interpretation of data but also the motivation for these designs. The thesis then proposes two methods for reducing the complexity of data in tactile sensing. The first is a low-power tactile sensing array exploiting a novel application of a pressure-sensitive material called quantum tunnelling composite. The properties of this material in this array form are shown to be beneficial in robotics. The electrical characteristics of the material are also explored. A bit-based structure for representing tactile data called Bitworld is then defined and its computational performance is characterised. It is shown that this bit-based structure outperforms floating-point arrays by orders of magnitude. This structure is then shown to allow high-resolution images to be produced by combining low resolution sensor arrays with equivalent functional performance to a floating-point array, but with the advantages of computational efficiency. Finally, an investigation into making Bitworld robust in the presence of positional noise is described with simulations to verify that such robustness can be achieved. Overall, the sensor and data structure described in this thesis allow simple, but effective tactile systems to be deployed in robotics without requiring a significant commitment of computational or power resources on the part of a robot designer.

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Shubitz, Lisa, Christine Butkiewicz, and Sharon M. Dial. "Cocci Skin Tests 2000." The University of Arizona, 2000. http://hdl.handle.net/10150/620000.

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An epidemiological survey of Valley Fever (coccidioidomycosis) was conducted in dogs in Tucson and Phoenix. Dogs were tested for delayed type hypersensitivity (DTH) using coccidioidin, a reagent that is not commercially available and results of the skin tests were compared with corresponding serologic test results.

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Shubitz, Lisa, and Christine Butkiewicz. "Cocci Skin Tests 2015." The University of Arizona, 2016. http://hdl.handle.net/10150/620002.

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Dogs in the Tucson area with a known history of clinical Valley Fever were tested with two skin test reagents to determine their ability to detect delayed type hypersensitivity (DTH) to the Coccidioides spp. The reagents used were Spherusol, from Nielsen Biologicals, and coccidioidin, which is no longer commercially available. Skin tests were read 48 hours after placement and evaluated for erythema and/or induration.

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41

Gartman, Kelly. "Living Without your Skin." ScholarWorks@UNO, 2004. http://scholarworks.uno.edu/td/73.

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Merriman, Carolyn. "Skin, Hair, and Nails." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/8531.

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Al-Masri, Antoun Salim. "Museum of Skin Instruments." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/35418.

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Skin is a very broad topic that allows discovering and exploring all the possibilities of what skin can be. Furthermore, skin is much known for its flexibility that can shape and wrap almost every object we can think of. At the beginning of my thesis research about skin, I thought I knew enough about it to start, but I discovered later on that skin is not a surface. Moreover, I directed myself into exploring more and more about skin and its characteristics. I built many models to help me understand some of the natural identity of skin and related materials. Those models became a concept for my project - a museum of skin instruments - in Alexandria, Virginia where I implied the mechanism of different skin instruments in each building. Exploration and experiments were the key to develop my design process.
Master of Architecture

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Bloomfield, Chris L. "In the Skin: Poems." Bowling Green State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1237118459.

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Turner, Sarah. "Voice on the Skin." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2126.

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“The body can write on the skin from the inside—the soul, the mind, and the passions rise to the surface in boils, blushes, and rashes, and the invisible inside speaks by writing from the other side of the page”. -James Elkins Skin not only covers but reveals what is behind it. I utilize its language as indicator of flaws and pathologies. I depict and manipulate this, not just as it already exists with the human body, but as projections of my psychological states onto inanimate objects. Proposing that sight is a kind of touch, we touch with our minds, through memory, experience, and emotions. Empathetic looking involves projecting ourselves onto the objects as each simultaneously projects itself onto us.

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Wiley, Candace G. "Blue skin, yellow flesh." Connect to this title online, 2009. http://etd.lib.clemson.edu/documents/1252937246/.

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Zeng, Huanzhao. "Preferred skin colour reproduction." Thesis, University of Leeds, 2011. http://etheses.whiterose.ac.uk/2090/.

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The memory colour reproduction is an important factor in judging image quality of photographic images of real life scenes. As the most important memory colour category, skin tone was extensively studied for preferred colour reproduction in this research. The methodology to study skin colour preference was then applied to study the colour preference of two other important colour categories: green foliage and blue sky. There are three essential parts for preferred skin colour enhancement: 1) building a skin colour model to detect skin colours or skin pixels; 2) finding a preferred skin colour region or a preferred skin colour centre; and 3) developing an algorithm to morph skin colours toward the preferred skin colour region. This study for skin colour enhancement started with the mathematical modelling of the skin colour region for skin colour detection. The modelling of skin colours was then applied to adjust skin colours of test images for psychophysical experiments that were to determine a preferred skin colour region. Finally, the skin colour modelling and the preferred skin colour centres were applied to adjust skin colours of digital photographic images for preferred colour reproduction. Two approaches were developed to model the skin colour distribution for skin colour detection. The first approach was to model a local colour region for general applications. A convex hull is constructed to fit the geometrical shape of a local region, and then the convex hull is approximated with mathematical formulae. The formulations and data fitting are adjusted with interactive 3-D visualization. The approach is flexible for fitting data gamut with various mathematical forms for different purposes. The other approach was to model skin colours with elliptical shapes. Three elliptical skin colour models were developed for skin colour detection. The first one is to model the skin colour cluster using a single ellipse ignoring the lightness (or luminance) dependency. It is simple and efficient, and the skin colour detection accuracy may be adequate for many applications. In the second model, the skin colour ellipse is adapted to different lightness so that the shape of the ellipse fits the skin colour cluster more accurately. The model is more complex to train and is less efficient in computation, but it is more accurate in skin colour detection. In the third method, an ellipsoid is trained to fit the skin colour cluster. It is almost as simple to train as the first model, but the skin colour detection accuracy is improved. Finally, these models were applied to train mixed skin colours, African skin colours, Caucasian skin colours, and Asian skin colours.

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Krishnan, Gayathri. "Skin penetration enhancement techniques." Thesis, Curtin University, 2011. http://hdl.handle.net/20.500.11937/1471.

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Transdermal drug delivery is an effective alternative to conventional oral and injectable drug delivery routes. It offers painless and convenient once daily or even once weekly dosing for a variety of clinical indications. The major limitation to successful transdermal drug delivery is the efficient barrier properties of the skin. Significant research efforts have been focused on developing strategies to overcome these barrier properties. These strategies include the use of physical and chemical penetration enhancers. Physical skin penetration enhancers use an external energy source to alter the barrier properties of the skin. The current research focuses on some of these physical skin penetration enhancers on a range of drug molecules and peptides.The first technology investigated was Dermaportation that utilised pulsed electromagnetic energy. This technology enhanced the epidermal permeation of naltrexone in vitro as compared to passive diffusion. A 5-fold increase in naltrexone permeation was observed during Dermaportation application when compared to passive administration. Multiphoton tomography-fluorescence life-time imaging microscopy (MPT-FLIM) analysis of the permeation of gold nanoparticles in the presence of Dermaportation revealed increased penetration across ex vivo human skin. These results demonstrated that the channels created by dermaportation must be larger than the 10 nm diameter of the applied nanoparticles.The second technology investigated was an unpowered magnetic film array technology (ETP), which utilised unpowered magnetic energy. Chapter 3 presents enhanced epidermal permeation of urea with ETP. A 4-fold increase in urea penetration was observed across human epidermis in the in vitro permeation study. Optical resonance tomography was used to visualise the changes in epidermal thickness due to urea permeation as an indication of increased hydration. The results revealed an increase in epidermal thickness at 30 min, to 16% for ETP induced urea permeation as compared to 3% with urea from occlusion. These results further substantiated our previous findings that magnetic energy creates hydrophilic diffusion channels or pores in the skin.The third technology investigated was low-frequency sonophoresis that utilises cavitation bubbles as a force to create channels for drug delivery in the skin. Chapter 4 presents enhanced human skin permeation of 5-aminolevuleninic acid in vitro and curcumin dye in vivo with low-frequency sonophoresis. Two different sources of ultrasound devices that generated low-frequency sonophoresis were investigated. MPT-FLIM analysis was utilised to investigate the effects of sonophoresis on human skin in vivo. This revealed that there was substantial disturbance in the epidermal cells due to cavitation by sonophoresis. Permeation of curcumin was found in the deeper layers of the epidermal membrane with 55 kHz sonophoresis and was confined to the more superficial layers of skin with 21 kHz sonophoresis. Permeation of 5-aminolevuleninic acid across human skin increased significantly when compared to passive permeation.The fourth technology investigated in this research was iontophoresis which utilises a small electric current to drive charged and uncharged molecules across the skin. Chapter 5 presents enhanced epidermal permeation of a range of model therapeutic and cosmetic peptides. Various key parameters such as pH, concentration and presence of counterions and co-ions that are essential for effective iontophoretic delivery of these peptides were investigated. The iontophoretic delivery of 5- aminolevulenic acid revealed a 15-fold enhancement when compared to passive diffusion. For dipeptide (Ala-Trp) the mean cumulative amount increased iontophoretic delivery from 0.4±0.4, 0.1μg/cm2 to 16.0±8.8, 3.6μg/cm2 (Mean±SD, SEM) was observed when the donor pH was reduced from 7.4 to 5.5. The corresponding current intensity (0.38mA/cm2) normalised flux was 36.1±19.5, 11.2μg/(mA.h) for iontophoretic Ala-Trp. For the tetrapeptide (Ala-Ala-Pro-Val) the mean cumulative amount that permeation with 2h iontophoresis was 350.4±45.9, 15.3μg/cm2 (Mean±SD, SEM) compared to zero passive permeation. A 4-fold increase in acetyl hexapeptide-3 delivery occurred with iontophoresis compared with passive application. In addition it was observed that lowering of donor solution pH and the presence of counterions and co-ions reduced the iontophoretic delivery of acetylhexapeptide-3. Iontophoresis provided a significant enhancement factor for the decapeptide, triptorelin acetate with a 16-fold increase in epidermal permeation compared with passive permeation. The iontophoretic permeation was concentration dependent with mean cumulative amounts of 48±28, 14 μg/cm2 (Mean±SD, SEM) achieved with 9 mM concentration of triptorelin acetate.Overall the technologies investigated in this research work presented enhanced permeation of drug molecules and peptides. In addition MPT-FLIM was demonstrated to be an efficient visualisation tool for permeation within the skin. This research demonstrates the effectiveness of physical skin permeation enhancement techniques and extends our understanding of these technologies.

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Pritchard-Jones, Rowan. "Expression of a novel inhibitory form of VEGF in skin and skin cancer." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435867.

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Dörr, Wolfgang. "Skin and Other Reactions to Radiotherapy – Clinical Presentation and Radiobiology of Skin Reactions." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133998.

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Dissertations / Theses on the topic 'Skin'

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