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1

Guerin, Bernard, and Robert D. Watson. "Skin Tests." Clinical Reviews in Allergy 6, no. 2 (September 1988): 211–27. http://dx.doi.org/10.1007/bf02914939.

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2

Cohen, Sheldon G., and Jean R. King. "Skin Tests." Immunology and Allergy Clinics of North America 21, no. 2 (May 2001): 191–249. http://dx.doi.org/10.1016/s0889-8561(05)70202-2.

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3

Leipzig, Jeffrey R., and Raymond G. Slavin. "Epicutaneous Skin Tests." Ear, Nose & Throat Journal 75, no. 11 (November 1996): 705–9. http://dx.doi.org/10.1177/014556139607501104.

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4

Starke, Jeffrey R. "TUBERCULIN SKIN TESTS." Pediatric Infectious Disease Journal 12, no. 7 (July 1993): 623. http://dx.doi.org/10.1097/00006454-199307000-00021.

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5

Mangi, Richard J. "Allergy Skin Tests." Otolaryngologic Clinics of North America 18, no. 4 (November 1985): 719–23. http://dx.doi.org/10.1016/s0030-6665(20)31819-3.

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6

Gale, Allen E. "Anaphylaxis after skin tests." Medical Journal of Australia 160, no. 3 (February 1994): 161. http://dx.doi.org/10.5694/j.1326-5377.1994.tb126571.x.

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7

Leipzig, Jeffrey R., and Raymond G. Slavin. "Immunology of Skin Tests." Ear, Nose & Throat Journal 75, no. 3 (March 1996): 132. http://dx.doi.org/10.1177/014556139607500306.

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8

Leipzig, Jeffrey R., and Raymond G. Slavin. "Disposable Epicutaneous Skin Tests." Ear, Nose & Throat Journal 75, no. 12 (December 1996): 762–63. http://dx.doi.org/10.1177/014556139607501204.

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9

Leipzig, Jeffrey R., and Raymond G. Slavin. "Single Intradermal Skin Tests." Ear, Nose & Throat Journal 76, no. 1 (January 1997): 16. http://dx.doi.org/10.1177/014556139707600105.

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10

Maderazo, Eufronio G. "Interpreting tuberculosis skin tests." Lancet 348, no. 9030 (September 1996): 832–33. http://dx.doi.org/10.1016/s0140-6736(05)65259-2.

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11

Kasik, J. E. "Skin Tests for Tuberculosis." Infection Control 8, no. 9 (September 1987): 350–52. http://dx.doi.org/10.1017/s0195941700067394.

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12

Balabolkin, I. I., and D. Sh Macharadze. "SKIN TESTS: INDICATIONS AND CONTRAINDICATIONS." Current pediatrics 12, no. 3 (May 14, 2013): 31. http://dx.doi.org/10.15690/vsp.v12i3.678.

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13

SULZINSKY, JOANNE E. "MORE ON TB SKIN TESTS." AJN, American Journal of Nursing 85, no. 6 (June 1985): 651. http://dx.doi.org/10.1097/00000446-198506000-00010.

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14

Backman, Alf. "Skin tests for epidemiologic studies." Allergy 49, no. 7 (August 1994): 493–94. http://dx.doi.org/10.1111/j.1398-9995.1994.tb01118.x.

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15

Goldberg, Arnon. "Variability of venom skin tests." Current Opinion in Allergy and Clinical Immunology 7, no. 4 (August 2007): 342–45. http://dx.doi.org/10.1097/aci.0b013e3281f828f8.

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16

Acaial, M. C., C. Brusl, S. Francalanci, M. Gola, and A. Sertoli. "Skin tests with fresh foods." Contact Dermatitis 24, no. 1 (January 1991): 67–68. http://dx.doi.org/10.1111/j.1600-0536.1991.tb01643.x.

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17

Ackroyd, J. F. "SKIN TESTS FOR PENICILLIN HYPERSENSITIVITY." Lancet 333, no. 8633 (February 1989): 335. http://dx.doi.org/10.1016/s0140-6736(89)91353-6.

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18

PALMACARLOS, L., A. PALMACARLOS, and M. MEDINA. "Skin Tests in Nsaids Hypersensitivity." Journal of Allergy and Clinical Immunology 121, no. 2 (February 2008): S192. http://dx.doi.org/10.1016/j.jaci.2007.12.712.

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19

Kontou-Fili, Kalliopi. "Patients with negative skin tests." Current Opinion in Allergy and Clinical Immunology 2, no. 4 (August 2002): 353–57. http://dx.doi.org/10.1097/00130832-200208000-00010.

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20

Asakawa, H., T. Araki, I. Imai, Y. Tsutsumi, and F. Kawakami. "Skin tests of steroid allergy." Allergy 54, no. 6 (June 1999): 645–46. http://dx.doi.org/10.1034/j.1398-9995.1999.00151.x.

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21

Palma-Carlos, A. G., M. Medina, and M. L. Palma-Carlos. "Skin tests in Nsaids hypersensitivity." World Allergy Organization Journal &NA; (November 2007): S267. http://dx.doi.org/10.1097/01.wox.0000301118.34925.35.

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22

Vichyanond, Pakit, and Harold S. Nelson. "Circadian variation of skin reactivity and allergy skin tests." Journal of Allergy and Clinical Immunology 83, no. 6 (June 1989): 1101–6. http://dx.doi.org/10.1016/0091-6749(89)90452-1.

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23

Ledford, Dennis K. "Skin Tests and In Vitro Tests for Insect Allergy." Journal of Allergy and Clinical Immunology: In Practice 4, no. 3 (May 2016): 562–63. http://dx.doi.org/10.1016/j.jaip.2016.03.014.

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24

Bansie, Rakesh D., A. Faiz Karim, Maurits S. van Maaren, Maud AW Hermans, Paul LA van Daele, Roy Gerth van Wijk, and Saskia M. Rombach. "Assessment of immediate and non-immediate hypersensitivity contrast reactions by skin tests and provocation tests: A review." International Journal of Immunopathology and Pharmacology 35 (January 2021): 205873842110150. http://dx.doi.org/10.1177/20587384211015061.

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Introduction: Allergic and nonallergic hypersensitivity reactions to iodinated contrast media (ICM) and gadolinium-based contrast media are classified as immediate or non-immediate hypersensitivity reactions (IHR and NIHR), respectively. Skin tests and provocation tests are recommended for the evaluation of hypersensitivity reactions to contrast agents; however provocations are not common in clinical practice. Methods: A MEDLINE search was conducted to investigate studies comprising both skin tests and provocation tests that evaluated hypersensitivity reactions to ICM. Results: Nineteen studies were identified that reported on skin tests, followed by provocations. In the case of IHR to ICM, 65/69 (94%) patients with a positive skin test for the culprit media tolerated a challenge with a skin-test-negative alternative ICM. In IHR to ICM with a negative skin test for the culprit media, provocations were positive in 3.2%–9.1% patients. In the case of a NIHR to ICM with a positive skin test, provocation with a skin-test-negative agent was tolerated in 75/105 (71%) of cases. In NIHR with a negative skin test for the culprit agent, re-exposure to the culprit or an alternative was positive in 0%–34.6% patients. Provocations with the same ICM in skin test positive patients with IHR or NIHR were positive for a majority of the patients, although such provocation tests were rarely performed. Data on hypersensitivity reactions, skin tests and provocations with gadolinium-based contrast media were limited; however, they exhibited a pattern similar to that observed in ICM. Conclusion: In both ICM and gadolinium-based contrast media, the risk of an immediate repeat reaction is low when skin tests are negative. In contrast, a provocation with a skin-test-positive contrast medium showed a high risk of an immediate repeat hypersensitivity reaction. Therefore, a thorough medical history is necessary, followed by skin tests. A provocation is recommended, for diagnostic work-up, when the diagnosis is uncertain.
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25

Mulé, Pasquale, Bruce Mazer, Danbing Ke, Duncan Lejtenyi, Liane Beaudette, Julia Upton, Edmond Chan, Ann Clarke, Sofianne Gabrielli, and Moshe Ben-Shoshan. "Temporal Trends of Skin Prick Tests." Journal of Allergy and Clinical Immunology 147, no. 2 (February 2021): AB171. http://dx.doi.org/10.1016/j.jaci.2020.12.606.

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26

Jacobs, Guido A., and Mark A. Martens. "OECD Skin Irritation Tests on Butylbenzene." Journal of the American College of Toxicology 11, no. 6 (November 1992): 732. http://dx.doi.org/10.3109/10915819209142125.

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27

Aouam, K., H. Belhadj Ali, S. Chaabane, M. Amri, N. A. Boughattas, and J. Zili. "DRESS Syndrome: Interest of Skin Tests." Drug Safety 29, no. 10 (2006): 911–1010. http://dx.doi.org/10.2165/00002018-200629100-00059.

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28

Kemper, Kathi J. "Follow-Up of Tuberculin Skin Tests." Journal of Health Care for the Poor and Underserved 5, no. 1 (1994): 1–4. http://dx.doi.org/10.1353/hpu.2010.0360.

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29

OLDFELT, VERA. "Skin Tests in Mumps Meningo-Encephalitis1." Acta Medica Scandinavica 142, no. 2 (April 24, 2009): 77–81. http://dx.doi.org/10.1111/j.0954-6820.1952.tb13845.x.

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30

Navin, Joanne A., Joshua E. Kaplan, and Elizabeth L. Desilvio. "Self-Reading of PPD Skin Tests." Journal of American College Health 43, no. 1 (July 1994): 37–38. http://dx.doi.org/10.1080/07448481.1994.9939083.

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31

Paye, M., V. Charbonnier, B. M. Morrison, and H. I. Maibach. "Suberythematous Skin Irritation Tests Using Squamometry." American Journal of Contact Dermatitis 12, no. 1 (March 2001): 57. http://dx.doi.org/10.1097/01634989-200103000-00032.

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32

Paye, M., V. Charbonnier, B. M. Morrison, and H. I. Maibach. "Suberythematous Skin Irritation Tests Using Squamometry." Dermatitis 12, no. 1 (March 2001): 57. http://dx.doi.org/10.1097/01206501-200103000-00032.

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33

Morell, F., V. Curull, R. Orriols, and J. De Gracia. "Skin tests in bird breeder's disease." Thorax 41, no. 7 (July 1, 1986): 538–41. http://dx.doi.org/10.1136/thx.41.7.538.

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34

Reichman, Lee B. "Tuberculin Skin Tests in Hospital Employees." Annals of Internal Medicine 124, no. 6 (March 15, 1996): 612. http://dx.doi.org/10.7326/0003-4819-124-6-199603150-00014.

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35

Bailey, Thomas C. "Tuberculin Skin Tests in Hospital Employees." Annals of Internal Medicine 124, no. 6 (March 15, 1996): 612. http://dx.doi.org/10.7326/0003-4819-124-6-199603150-00015.

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36

Antunes, João, Luís Borrego, Ana Romeira, and Paula Pinto. "Skin prick tests and allergy diagnosis." Allergologia et Immunopathologia 37, no. 3 (June 2009): 155–64. http://dx.doi.org/10.1016/s0301-0546(09)71728-8.

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37

Valyasevi, Mickey A., Daniel E. Maddox, and James T. C. Li. "Systemic reactions to allergy skin tests." Annals of Allergy, Asthma & Immunology 83, no. 2 (August 1999): 132–36. http://dx.doi.org/10.1016/s1081-1206(10)62624-5.

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38

Merali, Zeeya. "Human skin to replace animal tests." New Scientist 195, no. 2614 (July 2007): 14. http://dx.doi.org/10.1016/s0262-4079(07)61866-1.

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39

Alvares, Michael L., and David A. Khan. "Allergic Rhinitis with Negative Skin Tests." Current Allergy and Asthma Reports 11, no. 2 (December 2, 2010): 107–14. http://dx.doi.org/10.1007/s11882-010-0166-3.

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40

Wöhrl, S., K. Vigl, M. Binder, G. Stingl, and M. Prinz. "Automated Measurement of Skin Prick Tests." Journal of Allergy and Clinical Immunology 117, no. 2 (February 2006): S75. http://dx.doi.org/10.1016/j.jaci.2005.12.301.

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41

Charpin, D., M. Tafforeau, F. Pirson, D. Vervloet, and J. Charpin. "4 Relationship between skin tests to common allergens and skin tests or rast to hymenoptera venoms." Journal of Allergy and Clinical Immunology 81, no. 1 (January 1988): 169. http://dx.doi.org/10.1016/0091-6749(88)90241-2.

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42

Basketter, David, Geoff Gilpin, Michael Kuhn, Dick Lawrence, Fiona Reynolds, and Ed Whittle. "Patch tests versus use tests in skin irritation risk assessment." Contact Dermatitis 39, no. 5 (November 1998): 252–56. http://dx.doi.org/10.1111/j.1600-0536.1998.tb05919.x.

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43

Wood, Robert A., Wanda Phipatanakul, Robert G. Hamilton, and Peyton A. Eggleston. "A comparison of skin prick tests, intradermal skin tests, and RASTs in the diagnosis of cat allergy." Journal of Allergy and Clinical Immunology 103, no. 5 (May 1999): 773–79. http://dx.doi.org/10.1016/s0091-6749(99)70419-7.

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44

Hurst, David S., Bruce R. Gordon, and John H. Krouse. "The Importance of Glycerin-Containing Negative Control Tests in Allergy Research Studies that Use Intradermal Skin Tests." Otolaryngology–Head and Neck Surgery 127, no. 3 (September 2002): 177–81. http://dx.doi.org/10.1067/mhn.2002.127890.

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OBJECTIVE: We sought to assess skin whealing with glycerin-containing control injections for intradermal skin tests. DESIGN: Observational. METHODS: Wheal sizes were measured at 0, 10, and 15 minutes after intradermal injection of 0.01 and 0.02 mL of phenolated normal saline and 0.5% and 5% concentrations of glycerin in the same quantity of phenolated saline. RESULTS: Intradermal injection of 0.01 mL of phenolated saline produced an average 4.9-mm wheal, which expanded to 5.2 mm at 10 minutes and to 6.0 mm at 15 minutes. Intradermal injection of 0.02 mL of phenolated saline produced a 6.4-mm wheal, which expanded to 7.0 mm at 10 minutes and 8.0 mm at 15 minutes. The addition of glycerin produced proportionally larger wheals. CONCLUSIONS: Because glycerin increases whealing beyond that with phenolated saline, skin tests containing glycerin must be compared with glycerin-containing negative controls. Intradermal skin tests that fail to compare findings in this manner contain an inherent methodologic flaw and are uninterpretable. A major issue in allergy testing is deciding whether the observed skin response is truly indicative of the patient having a clinically relevant, IgE-mediated reaction. 1 Skin test results are influenced by many variables, including patient skin response, specific technique, and tester consistency. Wheal measurement, comparisons with positive and negative control solutions, and interpretation are of equal importance. The development of in vitro methods for allergy diagnosis has helped to independently verify the accuracy of skin tests. In some cases, poor standardization of antigen sources and testing techniques has been shown to lead to discrepancies between skin tests and in vitro IgE antibody results of more than 100-fold. 2 It is also possible for skin tests to be falsely negative, as has been shown by comparing IgE blood tests with both skin tests and challenge tests. 3 Conversely, skin tests may be falsely positive because of nonspecific irritants, such as glycerin, present in allergen solutions. 4,5 Recommendations for immunotherapy must be based on clinical appropriateness as related to valid testing of proposed therapeutic agents. Recent reports by Nelson et al 6 and Wood et al 7 have suggested that skin prick tests (SPTs), even when negative, are sufficiently sensitive to diagnose clinical atopy without the need for further intradermal skin tests (IDTs). Both authors describe performance of a single IDT with injection of 0.02 mL of antigen solution. The basic tenant of their methodology is that all wheals resulting from an IDT measuring 6 mm or greater, accompanied by erythema, are to be recorded as positive. Nelson et al took measurements at 15 minutes, and Wood et al took measurements at an unspecified time. We were concerned that their methodology for IDTs created many false-positive results. This led to the condemnation of IDTs by these authors, stating that “a positive intradermal skin test response to Timothy grass in the presence of a negative skin prick test response to Timothy grass did not indicate the presence of clinically significant sensitivity to Timothy grass.” 6 We found the conclusion based on their particular IDT method to be suspect for 2 reasons: (1) it categorically assumes that an injection of 0.02 would produce a wheal of less than 6 mm and (2) it ignores the effects of small concentrations of the preservative glycerin, used in most all allergy test solutions, on whealing. Either assumption would lead to frequent false-positive skin test interpretations and discredit 60 years of intradermal testing. We therefore sought to evaluate control tests appropriate for use with the methodologies published in the general allergy literature to determine whether a 6-mm wheal with erythema should appropriately be interpreted as a positive or as a negative test.
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45

WU, JOHN Z., REN G. DONG, W. PAUL SMUTZ, and AARON W. SCHOPPER. "EFFECTS OF PRECONDITIONING ON THE ELASTIC BEHAVIOR OF SKIN UNDER COMPRESSIVE LOADING." Journal of Mechanics in Medicine and Biology 03, no. 03n04 (September 2003): 275–83. http://dx.doi.org/10.1142/s0219519403000788.

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In physiological loading conditions, the skin tissues are, sometimes, loaded compressively. The mechanical characteristics of skins in tension have been studied intensively, while those in compression have not been studied thoroughly. Previous studies suggested that, in order to obtain repeatable mechanical parameters, the skin sample should be properly preconditioned in the tensile tests. The present study is to investigate if the skin sample should be preconditioned in the compressive tests. Pigskins were used in the present study. Compression tests were performed in confined and unconfined loading configurations and at four different loading speeds (0.5, 1.0, 40, and 400 μm/s). Our results show that skin samples should be preconditioned in compressive tests, to obtain repeatable mechanical parameters. The necessary number of the loading cycles in the preconditioning treatment for compressive testing is less than that for tensile testing. Our findings indicate that the skin samples reach repeatable mechanical behavior after 3–4 loading cycles, independent of the loading rate and loading configurations (confined or unconfined compressions).
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46

R de Freitas, Gabriel, Judith Miklossy, Stephanie Christen-Zäch, Marc Reichhart, and Julien Bogousslavsky. "False-Negative Tests in CADASIL." Stroke 32, suppl_1 (January 2001): 341. http://dx.doi.org/10.1161/str.32.suppl_1.341-b.

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P14 Background: The diagnosis of CADASIL is normally confirmed by screening DNA for mutations of Notch 3 gene or by skin biopsy. The pathological hallmark of this disease is the presence of characteristic granular osmiophilic material within the basal membrane of vascular smooth-muscle cells. Objective: We report the first CADASIL case with negative results for both genetic analysis and skin biopsy. Methods: A 69-year-old woman presented with recurrent TIA and strokes, seizures, and dementia. MRI revealed diffuse periventricular white matter abnormalities. Extensive investigation failed to reveal the cause of the disease. Analysis for CADASIL were performed. Results: The patient had no mutations in the Notch 3 gene, had a normal skin biopsy, but showed characteristic CADASIL abnormalities on brain pathological examination. Ultrastructural analysis of the brain showed marked destruction of smooth muscle cells with an accumulation of granular osmiophilic material in the muscular layer. Conclusion: Our findings suggest that negative results in the skin biopsy and genetic test do not exclude the disease, and a leptomeningeal biopsy should be considered in such cases. CADASIL may be more common than previously reported.
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47

Tornero Molina, P., P. Rojas-Perez-Ezquerra, B. Noguerado-Mellado, ML Baeza Ochoa de Ocáriz, A. Garrido Sánchez, M. Alonso Mateos, and JM Zubeldia Ortuño. "Drug Challenge Tests With General Anesthetics: Predictive Value of Skin Tests." Journal of Investigational Allergology and Clinical Immunology 30, no. 2 (April 23, 2020): 101–7. http://dx.doi.org/10.18176/jiaci.0402.

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48

Ene-Cociș, M., M. Mureșan, C. Petrișor, N. Hagău, and N. Onițiu-Gherman. "Incidence of systemic reactions to skin tests and drug challenge tests." Revue Française d'Allergologie 58, no. 5 (September 2018): 367–72. http://dx.doi.org/10.1016/j.reval.2018.03.001.

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49

Titova, N. "Skin tests in the diagnosis of food allergy." Immunopathology, Allergology, Infectology 2021, no. 4 (October 1, 2021): 6–13. http://dx.doi.org/10.14427/jipai.2021.4.6.

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Skin tests are an important step in diagnosing food allergy. Several types of skin tests are used: prick test, intradermal, patch tests, as well as a special version of skin tests - these are tests with native (fresh allergens) – prick-prick tests. We review sensitivity, specificity, the possibility of false positive and false negative results when using natural products in testing. The safety of skin tests and certain contraindications for their use have to be considered. The advantages of using fresh products specimens for skin tests, their high sensitivity and negative predictive value of tests are described. This allows to reduce the likelihood of missing true positives:: the real patients with risk of a severe systemic reaction.
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50

Rochmah, Nur, Dyahris Kuntartiwi, Anang Endaryanto, and Aryanto Harsono. "Inverse association between positive tuberculin tests and positive allergy skin tests in children." Paediatrica Indonesiana 49, no. 1 (March 1, 2009): 7. http://dx.doi.org/10.14238/pi49.1.2009.7-10.

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Background The association between Mycobacterium tuberculosisinfection and atopy remains controversial. Reaction to tuberculosisinfection is mediated by Th-1 immune responses whereas allergicreactions are mediated by Th- 2 immune response. In patients withatopic syndrome who also suffer from tuberculosis infection, theTh-2 response will be suppressed and allergy manifestations willdecrease. Therefore, it is important to determine the appropriateallergy test and to predict outcome after completing tuberculosistreatment.Objective To evaluate the influence of a positive tuberculin teston skin test results in diagnosing atopic disease.Methods A cross sectional study was conducted in the pediatricallergy outpatient clinic, Soetomo Hospital, Surabaya, Indonesiabetween 2004 and 2007. Eighty-five patients were enrolled inthis study. The tuberculin test was performed on all patientswith allergy. The allergy test was carried out by performing a skinscratch test.Results There was a weak inverse correlation between positivetuberculin tests and positive allergy skin tests in children (housedust mite, food and pet allergies). The correlation between apositive tuberculin test and house dust mite allergy test wasr: -0.364 (P=O.OOl; a=O.Ol). The correlation between thetuberculin test and food allergies was r: -0.420 (P=O.OOl;a=O.Ol). The correlation between the tuberculin test and petallergies was r: -0.344 (P= 0.001; a=O.Ol).Conclusions A positive tuberculin test is weakly correlated withpositive allergy skin test results, suggesting that it is appropriate todo allergy skin testing even in children with a positive tuberculintest.
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