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Journal articles on the topic 'Skin pathologies'

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Author: Grafiati

Published: 30 May 2022

Last updated: 31 May 2022

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1

Snarskaya, Elena Sergeevna, Olga Yurievna Olisova, Alexander Davidovich Makatsariya, Nikolai Georgievich Kochergin, Lyudmila Radetskaya, Viktoriya Bitsadze, and Jamilya Khizroeva. "Skin pathologies in pregnancy." Journal of Perinatal Medicine 47, no. 4 (May 27, 2019): 371–80. http://dx.doi.org/10.1515/jpm-2018-0338.

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Abstract Progesterone is a hormone responsible for pregnancy maintenance and the amount of progesterone increases in a woman’s body during pregnancy, as well as the level of female sex hormones, estrogens are also upregulated. Due to these changes the cutaneous sensitivity to external stimuli (meteorological factors, bacteria, etc.) increases. In general, all skin changes during pregnancy can be divided into three groups: physiological changes (hormone-associated), nonspecific or dermatoses that existed before pregnancy or were triggered by it, and specific pregnancy-related dermatoses, which appear during pregnancy and resolve in the postpartum period. In this brief review, we describe the dermatoses commonly seen in pregnancy and present our own clinical examples. We hope the review will be of some practical help for dermatologists and obstetricians.

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2

Bongiovanni, Laura, Eliane J. Müller, and Leonardo Della Salda. "Survivin in skin pathologies." Experimental Dermatology 20, no. 6 (May 18, 2011): 457–63. http://dx.doi.org/10.1111/j.1600-0625.2011.01273.x.

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3

Cobo, Ramón, Jorge García-Piqueras, Juan Cobo, and José A. Vega. "The Human Cutaneous Sensory Corpuscles: An Update." Journal of Clinical Medicine 10, no. 2 (January 10, 2021): 227. http://dx.doi.org/10.3390/jcm10020227.

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Sensory corpuscles of human skin are terminals of primary mechanoreceptive neurons associated with non-neuronal cells that function as low-threshold mechanoreceptors. Structurally, they consist of an extreme tip of a mechanosensory axon and nonmyelinating peripheral glial cells variably arranged according to the morphotype of the sensory corpuscle, all covered for connective cells of endoneurial and/or perineurial origin. Although the pathologies of sensitive corpuscles are scarce and almost never severe, adequate knowledge of the structure and immunohistochemical profile of these formations is essential for dermatologists and pathologists. In fact, since sensory corpuscles and nerves share a basic structure and protein composition, a cutaneous biopsy may be a complementary method for the analysis of nerve involvement in peripheral neuropathies, systemic diseases, and several pathologies of the central nervous system. Thus, a biopsy of cutaneous sensory corpuscles can provide information for the diagnosis, evolution, and effectiveness of treatments of some pathologies in which they are involved. Here, we updated and summarized the current knowledge about the immunohistochemistry of human sensory corpuscles with the aim to provide information to dermatologists and skin pathologists.

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4

Cobo, Ramón, Jorge García-Piqueras, Juan Cobo, and José A. Vega. "The Human Cutaneous Sensory Corpuscles: An Update." Journal of Clinical Medicine 10, no. 2 (January 10, 2021): 227. http://dx.doi.org/10.3390/jcm10020227.

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Sensory corpuscles of human skin are terminals of primary mechanoreceptive neurons associated with non-neuronal cells that function as low-threshold mechanoreceptors. Structurally, they consist of an extreme tip of a mechanosensory axon and nonmyelinating peripheral glial cells variably arranged according to the morphotype of the sensory corpuscle, all covered for connective cells of endoneurial and/or perineurial origin. Although the pathologies of sensitive corpuscles are scarce and almost never severe, adequate knowledge of the structure and immunohistochemical profile of these formations is essential for dermatologists and pathologists. In fact, since sensory corpuscles and nerves share a basic structure and protein composition, a cutaneous biopsy may be a complementary method for the analysis of nerve involvement in peripheral neuropathies, systemic diseases, and several pathologies of the central nervous system. Thus, a biopsy of cutaneous sensory corpuscles can provide information for the diagnosis, evolution, and effectiveness of treatments of some pathologies in which they are involved. Here, we updated and summarized the current knowledge about the immunohistochemistry of human sensory corpuscles with the aim to provide information to dermatologists and skin pathologists.

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5

Stolbova, O. "SKIN DISEASES OF DIFFERENT ETIOLOGY IN DOGS." THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL, no. 22 (May 19, 2021): 504–8. http://dx.doi.org/10.31016/978-5-6046256-1-3.2021.22.504-508.

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Currently, skin pathologies in animals are of close attention by veterinary practitioners, since the qualities of service dogs are reduced against their background, as well as natural resistance is decreased, which contributes to the emergence of skin diseases of different etiology. In this regard, a goal was set to study and analyze the occurrence of skin diseases of different etiology in dogs. To study skin pathologies in dogs, animals were examined from 2010–2018. According to the results of the data obtained, we found that skin diseases were widespread. Among skin pathologies, diseases of parasitic etiology, allergic diseases, infectious skin diseases, diseases caused by formation of neoplasms, as well as endocrine dermopathy were recorded. At the same time, the taxonomic composition of parasites in dogs was represented by 8 species, of which the class Arachnida, Cuvier, 1812 by five species of parasites, and the class Insécta, Linnaeus, 1758 by three representatives. For skin pathologies of infectious nature, representatives of these classes are Bacillales Erenberg, 1835 (Staphylococcus Rosenbach, 1884; Streptococcus Rosenbach, 1884) and the class Eurotiomycetes Microsporum Gruby 1843; Trichophyton verrucosum (Boden, 1902).

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6

Morales-Avalos, Rodolfo, and Priscila Madelein Requena-Araujo. "The Dynamic Microanatomy of skin and fascia. From the deep fascia to the skin surface." Dermatology and Dermatitis 2, no. 2 (May 23, 2018): 01–05. http://dx.doi.org/10.31579/2578-8949/024.

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The study of the structure of the skin and fascia in recent years has made important advances with respect to the "dynamic anatomy" that they present, that is, the anatomical relationships and tissue interconnections that you share through different tissues. In the same way fascias have been recognized as important sources of origin of different pathologies in the last years, so the greater knowledge of their function and structure is indispensable. The aim of this article is to review the last advances in the anatomic terminology of the soft superficial tissues as advances and recent anatomical discoveries.

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7

Esposito, Elisabetta, Claudio Nastruzzi, Maddalena Sguizzato, and Rita Cortesi. "Nanomedicines to Treat Skin Pathologies with Natural Molecules." Current Pharmaceutical Design 25, no. 21 (September 26, 2019): 2323–37. http://dx.doi.org/10.2174/1381612825666190709210703.

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The skin and mucous membranes are subjected to many disorders and pathological conditions. Nature offers a wide range of molecules with antioxidant activity able to neutralize, at least in part, the formation of free radicals and therefore to counteract the phenomena of cellular aging. Since synthetic drugs for the treatment of skin diseases can induce resistance, it is particularly interesting to use compounds of plant origin, transporting them in pharmaceutical forms capable of controlling their release and absorption. This review provides an overview of new findings about the use of lipid-based nanosystems for the delivery of natural molecules useful on the topical treatment of skin disorders. Several natural molecules encapsulated in lipid nanosystems have been considered in the treatment of some skin pathologies or diseases. Particularly, the use of rosemary and eucalyptus essential oil, saffron derivatives, curcumin, eugenol, capsaicin, thymol and lycopene has been reported. The molecules have been alternatively encapsulated in viscous systems, such as the organogels, or in liquid systems, such as ethosomes, transferosomes, solid lipid nanoparticles and monoolein based dispersions thickened by inclusion in carbomer gels. The nanostructured forms have been in vitro and in vivo investigated for the treatment of skin disorders due to dehydration, inflammation, melanoma, wound healing, fungal infections or psoriasis. The data reported in the different studies have suggested that the cutaneous application of lipid nanosystems allows a deep interaction between lipid matrix and skin strata, promoting a prolonged release and efficacy of the loaded natural molecules. This review suggests that the application of natural molecules onto the skin by lipid-based nanosystems can provide numerous clinician benefits in dermatology and cosmetics.

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8

Bratchenko, I. A., M. V. Alonova, O. O. Myakinin, A. A. Moryatov, S. V. Kozlov, and V. P. Zakharov. "Hyperspectral visualization of skin pathologies in visible region." Computer Optics 40, no. 2 (January 1, 2016): 240–48. http://dx.doi.org/10.18287/2412-6179-2016-40-2-240-248.

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9

Gieringer, Matthias, Ramin Naim, Karl Hormann, Katherine Elliott, Alexander Sauter, and Jan Gosepath. "Angiogenesis in Different Types of the Skin: Pathologies." Otolaryngology–Head and Neck Surgery 141, no. 2_suppl (September 2009): P34—P35. http://dx.doi.org/10.1016/j.otohns.2009.06.099.

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10

Bristow, Ivan. "Non-ulcerative skin pathologies of the diabetic foot." Diabetes/Metabolism Research and Reviews 24, S1 (2008): S84—S89. http://dx.doi.org/10.1002/dmrr.818.

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11

Brooks, Anna E. S. "Skin-resident CD4+ T cells express NK receptors: Lessons from skin pathologies." Cytometry Part A 85, no. 10 (July 18, 2014): 827–29. http://dx.doi.org/10.1002/cyto.a.22492.

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12

Csekes, Erika, and Lucia Račková. "Skin Aging, Cellular Senescence and Natural Polyphenols." International Journal of Molecular Sciences 22, no. 23 (November 23, 2021): 12641. http://dx.doi.org/10.3390/ijms222312641.

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The skin, being the barrier organ of the body, is constitutively exposed to various stimuli impacting its morphology and function. Senescent cells have been found to accumulate with age and may contribute to age-related skin changes and pathologies. Natural polyphenols exert many health benefits, including ameliorative effects on skin aging. By affecting molecular pathways of senescence, polyphenols are able to prevent or delay the senescence formation and, consequently, avoid or ameliorate aging and age-associated pathologies of the skin. This review aims to provide an overview of the current state of knowledge in skin aging and cellular senescence, and to summarize the recent in vitro studies related to the anti-senescent mechanisms of natural polyphenols carried out on keratinocytes, melanocytes and fibroblasts. Aged skin in the context of the COVID-19 pandemic will be also discussed.

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13

Boivin, Wendy A., Rani P. Cruz, Hongyan Zhao, Tyler Varnals, David C. Walker, and David J. Granville. "Granzyme B and perforin in atherosclerosis and skin pathologies." Matrix Biology 27 (December 2008): 40. http://dx.doi.org/10.1016/j.matbio.2008.09.343.

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14

Vinokurov, V., Yu Khristoforova, O. Myakinin, I. Bratchenko, A. Moryatov, A. Machikhin, and V. Zakharov. "Neural network classifier for hyperspectral images of skin pathologies." Journal of Physics: Conference Series 2127, no. 1 (November 1, 2021): 012026. http://dx.doi.org/10.1088/1742-6596/2127/1/012026.

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Abstract This paper describes the use and results of a neural network classifier trained on a set of hyperspectral images of benign and malignant neoplasms. The analysis is carried out on 2D images extruded from hyperspectral data. The ranges of wavelengths at which the research is carried out is represented by the intervals 530–570 nm and 600–606 nm, which is caused by the assumption that the analysis of the entire spectral range is redundant and the prospect of saving resources. Melanoma, basal cell carcinoma (BCC), nevus and papilloma are accepted as primary classes, as the most dangerous, most common and non-malignant types of neoplasms, respectively. The neural network classifier is based on a three-block VGG network. With a training set included 1944 images, the classification accuracy for 4 types of samples was 92%.

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15

Vinokurov, V. O., I. A. Matveeva, Y. A. Khristoforova, O. O. Myakinin, I. A. Bratchenko, L. A. Bratchenko, A. A. Moryatov, et al. "Neural network classifier of hyperspectral images of skin pathologies." Computer Optics 45, no. 6 (November 2021): 879–86. http://dx.doi.org/10.18287/2412-6179-co-832.

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The paper presents results of using a neural network classifier to analyze images of malignant skin lesions obtained using a hyper-spectral camera. Using a three-block neural network of VGG architecture, we conducted the classification of a set of two-dimensional images of melanoma, papilloma and basal cell carcinoma, obtained in the range of 530 – 570 and 600 – 606 nm, characterized by the highest absorption of melanin and hemoglobin. The sufficiency of the inclusion in the training set of two-dimensional images of a limited spectral range is analyzed. The results obtained show significant prospects of using neural network algorithms for processing hyperspectral data for the classification of skin pathologies. With a relatively small set of training data used in the study, the classification accuracy for the three types of neoplasms was as high as 96 %.

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16

Shuginina, Elena A., and Olga I. Rassokhina. "Principles of Non-Pharmacological Correction of Skin Toxicity and Skin Manifestations of a Chronic «Graft Versus Host» Disease." Oncopediatrics 6, no. 2 (July 24, 2019): 87–93. http://dx.doi.org/10.15690/onco.v6i2.2020.

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This publication focuses on skin toxicity and skin manifestations of a chronic graft versus host disease (chGVHD). The article provides analysis of contemporary literature on these pathologies, presents new approach to preventing its development and also introduces pathogenetically determined patterns of non-drug correction of skin manifestations.

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17

Jiang, Lina, Yizhou Jiang, Xiaohui Ji, Jiangtao Li, and Ximei Zhai. "MiR-132 enhances proliferation and migration of HaCaT cells by targeting TIMP3." RSC Advances 9, no. 37 (2019): 21125–33. http://dx.doi.org/10.1039/c8ra10552a.

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18

Hurabielle, Charlotte, Verena M. Link, Nicolas Bouladoux, Seong-Ji Han, Eric Dean Merrill, Yaima L. Lightfoot, Nickie Seto, et al. "Immunity to commensal skin fungi promotes psoriasiform skin inflammation." Proceedings of the National Academy of Sciences 117, no. 28 (June 29, 2020): 16465–74. http://dx.doi.org/10.1073/pnas.2003022117.

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Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell responses, is expected to precede any inflammatory trigger. How this pool of preformed microbiota-specific T cells contributes to tissue pathologies remains unclear. Here, using an experimental model of psoriasis, we show that recall responses to commensal skin fungi can significantly aggravate tissue inflammation. Enhanced pathology caused by fungi preexposure depends on Th17 responses and neutrophil extracellular traps and recapitulates features of the transcriptional landscape of human lesional psoriatic skin. Together, our results propose that recall responses directed to skin fungi can directly promote skin inflammation and that exploration of tissue inflammation should be assessed in the context of recall responses to the microbiota.

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19

Johnson, GR, P. Han, and JA Giacopelli. "Tissue expansion as an alternative to skin grafting for closure of skin deficits." Journal of the American Podiatric Medical Association 82, no. 5 (May 1, 1992): 249–59. http://dx.doi.org/10.7547/87507315-82-5-249.

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Recent advances in the technical aspects of tissue expanders for closure of skin deficits have led to an overall reduction in the high rate of complications typically associated with their usage. The authors provide a review of the recent refinements in the technique of the tissue expansion process. A discussion of current and future applications using this technique in the treatment of various lower extremity pathologies, including clubfoot, is presented. A case report on the use of a subcutaneous tissue expander for the treatment of a failed skin graft of the medial ankle is included.

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20

Arasiewicz, Hubert, Martyna Zbiciak-Nylec, and Ligia Brzezińska-Wcisło. "Pathologies of the skin and its appendages in endocrine diseases." Dermatology Review 2 (2016): 143–52. http://dx.doi.org/10.5114/dr.2016.59137.

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21

Jerjes, W., Z. Hamdoon, T. Upile, and C. Hopper. "Photodynamic therapy outcome for skin pathologies: A single institute experience." Photodiagnosis and Photodynamic Therapy 8, no. 2 (June 2011): 145. http://dx.doi.org/10.1016/j.pdpdt.2011.03.074.

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22

Szauter, Kornelia Molnarne, Tongyu Cao, Charles D. Boyd, and Katalin Csiszar. "Lysyl oxidase in development, aging and pathologies of the skin." Pathologie Biologie 53, no. 7 (September 2005): 448–56. http://dx.doi.org/10.1016/j.patbio.2004.12.033.

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23

Bouer, Marcio. "2087299 Ultrasound Aplication With High Frequency Transducer In Skin Pathologies." Ultrasound in Medicine & Biology 41, no. 4 (April 2015): S15. http://dx.doi.org/10.1016/j.ultrasmedbio.2014.12.108.

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24

de Jesus, Priscila da Costa C., Sabrina Ikeda N. Saeki, and Antonio Claudio Tedesco. "Anex vivostudy of photobiostimulation in the treatment of skin pathologies." Journal of Biophotonics 9, no. 11-12 (March 15, 2016): 1189–98. http://dx.doi.org/10.1002/jbio.201500288.

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25

Rajesh, Aarthi, Lyn Wise, and Merilyn Hibma. "The role of Langerhans cells in pathologies of the skin." Immunology & Cell Biology 97, no. 8 (May 8, 2019): 700–713. http://dx.doi.org/10.1111/imcb.12253.

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26

Jerjes, W., Z. Hamdoon, and C. Hopper. "Photodynamic therapy outcome for skin pathologies: a single institute experience." British Journal of Oral and Maxillofacial Surgery 49 (June 2011): S71. http://dx.doi.org/10.1016/j.bjoms.2011.03.135.

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27

Ben Yehuda Greenwald, Maya, Marina Frušić-Zlotkin, Yoram Soroka, Shmuel Ben Sasson, Ronit Bitton, Havazelet Bianco-Peled, and Ron Kohen. "Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–17. http://dx.doi.org/10.1155/2017/5205471.

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Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin are being hampered by its insufficient solubility, chemical instability, and poor absorption, leading to low efficacy in preventing skin pathologies. These limitations can be overcome by using a nanotechnology-based delivery system. Here, we elucidated the possibility of using curcumin encapsulated in a microemulsion preserving its unique chemical structure. We also examined whether curcumin microemulsion would reduce UVB-induced toxicity in skin. A significant curcumin concentration was found in the human skin dermis following topical application of a curcumin microemulsion. Moreover, curcumin microemulsion enhanced the reduction of UV-induced cytotoxicity in epidermal cells, paving the way for other incorporated electrophiles in encapsulated form protecting skin against stress-related diseases.

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28

Asano, Yoshihide. "The Pathogenesis of Systemic Sclerosis: An Understanding Based on a Common Pathologic Cascade across Multiple Organs and Additional Organ-Specific Pathologies." Journal of Clinical Medicine 9, no. 9 (August 19, 2020): 2687. http://dx.doi.org/10.3390/jcm9092687.

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Systemic sclerosis (SSc) is a multisystem autoimmune and vascular disease resulting in fibrosis of various organs with unknown etiology. Accumulating evidence suggests that a common pathologic cascade across multiple organs and additional organ-specific pathologies underpin SSc development. The common pathologic cascade starts with vascular injury due to autoimmune attacks and unknown environmental factors. After that, dysregulated angiogenesis and defective vasculogenesis promote vascular structural abnormalities, such as capillary loss and arteriolar stenosis, while aberrantly activated endothelial cells facilitate the infiltration of circulating immune cells into perivascular areas of various organs. Arteriolar stenosis directly causes pulmonary arterial hypertension, scleroderma renal crisis and digital ulcers. Chronic inflammation persistently activates interstitial fibroblasts, leading to the irreversible fibrosis of multiple organs. The common pathologic cascade interacts with a variety of modifying factors in each organ, such as keratinocytes and adipocytes in the skin, esophageal stratified squamous epithelia and myenteric nerve system in gastrointestinal tract, vasospasm of arterioles in the heart and kidney, and microaspiration of gastric content in the lung. To better understand SSc pathogenesis and develop new disease-modifying therapies, it is quite important to understand the complex pathogenesis of SSc from the two distinct perspectives, namely the common pathologic cascade and additional organ-specific pathologies.

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29

Abdulmutalimova, T. O., and G. D. Mamasheva. "The quality of drinking water as a risk-factor of skin lesions among the North Daghestan population." Medical Herald of the South of Russia 9, no. 3 (October 1, 2018): 58–64. http://dx.doi.org/10.21886/2219-8075-2018-9-3-58-64.

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Objective: to study the epidemiological features of the spread of arsenodermatitis among the population of Northern Dagestan with the identification of populations most exposed to arsenic.Materials and methods: in the course of this study, 915 case histories of patients of the Republic Dermatovenerologic Dispensary, who have lived for more than 5 years in the territory of the hydrogeochemical anomaly, were analyzed. The study of ethnic predisposition to the development of skin pathologies was carried out on the basis of an analysis of available literature data.Results: 40.6 % of the population use artesian water with arsenic contamination 20-50 times higher than the permissible level for drinking. The prevailing localization in the analysis of the general structure of skin diseases of a noninfectious nature by study areas is the various forms of the psoriases, which were detected in half of the patients (51.6%). The spread of skin pathologies among different ethnic groups in North Dagestan did not reveal any differences.Conclusions: the clinical cases of dermatitis among the patients of the Republic Dermatovenerologic Dispensary revealed in the population are characterized by symptoms similar to those described in the literature of arsenodermatitis. To verify the data, it is necessary to conduct detailed studies using biomarkers (hair, urine) in exposed groups of the populationwith identified skin pathologies consuming water with different levels of arsenic for drinking.

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30

Murashkin, Nikolay N., Alena A. Savelova, Roman A. Ivanov, Eduard T. Ambarchian, Alexander I. Materikin, Roman V. Epishev, and Leonid A. Opryatin. "Etiopathogenetic Similarities of Combined Forms of Localized Scleroderma and Vitiligo." Current Pediatrics 19, no. 6 (December 27, 2020): 452–59. http://dx.doi.org/10.15690/vsp.v19i6.2147.

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Vitiligo is a common skin disease characterized by idiopathic progressive skin hypomelanosis. Vitiligo is associated with several comorbid autoimmune diseases such as localized scleroderma. This article demonstrates the general development mechanism of these pathologies, as well as the key aspect of cross-effect between autoimmune diseases on the molecular level. Recently, dermatologists have noted the increasing number of patients suffering from combined pathologies. Such patients (in pediatrics) have torpid course of disease and no pathognomonic symptoms. That exaggerates the diagnostics and adequate therapy prescription. This leads to increased awareness among physicians of different specialties on possible combinations, clinical presentation and pathogenesis aspects of such conditions.

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31

Banerjee, Jaideep, Yuk Cheung Chan, and Chandan K. Sen. "MicroRNAs in skin and wound healing." Physiological Genomics 43, no. 10 (May 2011): 543–56. http://dx.doi.org/10.1152/physiolgenomics.00157.2010.

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MicroRNAs (miRNAs) are small endogenous RNA molecules ∼22 nt in length. miRNAs are capable of posttranscriptional gene regulation by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation or suppression of translation. miRNAs have recently been shown to play pivotal roles in skin development and are linked to various skin pathologies, cancer, and wound healing. This review focuses on the role of miRNAs in cutaneous biology, the various methods of miRNA modulation, and the therapeutic opportunities in treatment of skin diseases and wound healing.

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32

de Veer, Simon J., Laetitia Furio, Jonathan M. Harris, and Alain Hovnanian. "Proteases and proteomics: Cutting to the core of human skin pathologies." PROTEOMICS - Clinical Applications 8, no. 5-6 (April 13, 2014): 389–402. http://dx.doi.org/10.1002/prca.201300081.

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33

Katoh, Masaru. "FGFR2 Abnormalities Underlie a Spectrum of Bone, Skin, and Cancer Pathologies." Journal of Investigative Dermatology 129, no. 8 (August 2009): 1861–67. http://dx.doi.org/10.1038/jid.2009.97.

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34

Strąkowska, Maria, Robert Strąkowski, Michał Strzelecki, Gilbert De Mey, and Bogusław Więcek. "Thermal modelling and screening method for skin pathologies using active thermography." Biocybernetics and Biomedical Engineering 38, no. 3 (2018): 602–10. http://dx.doi.org/10.1016/j.bbe.2018.03.009.

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35

Abuabara, Allan, Celso Alfredo Schramm, João César Zielak, and Flares Baratto-Filho. "Dental infection simulating skin lesion." Anais Brasileiros de Dermatologia 87, no. 4 (August 2012): 619–21. http://dx.doi.org/10.1590/s0365-05962012000400017.

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Orocutaneous fistulas or cutaneous sinus, a tract of dental origin, is an uncommon but welldocumented condition that usually requires emergency treatment. Such condition may be misdiagnosed by physicians and dentists and may sometimes be confused with bone and skin tumor, osteomyelitis, congenital fistula, salivary gland fistula, pyogenic granuloma, infected cyst, deep mycotic infection, and other pathologies. A case of facial sinus tract that was initially misdiagnosed by a physician as a nonodontogenic lesion is presented. Nonsurgical endodontic therapy was the treatment of choice for this case. Facial cutaneous sinus tracts must be considered of dental origin. Early diagnosis and prompt treatment minimize patient discomfort and esthetic problems, reducing the possibility of further complications such as sepsis and osteomyelitis.

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36

Sedoshkina, K., and S. Filioglo. "Dog’s Juvenile Cellulite." Bulletin of Science and Practice 5, no. 4 (April 15, 2019): 245–47. http://dx.doi.org/10.33619/2414-2948/41/32.

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According to statistics, dermatological pathologies of animals occupy one of the first places in the frequency of occurrence. In addition to infections and allergic reactions, there are autoimmune diseases that occur with the defeat of the skin, as well as pathologies with unknown etiology. Juvenile cellulite (washing of puppies, juvenile pyoderma) is a rare, idiopathic form of panniculitis of young dogs, more often puppies, characterized by generalized aseptic inflammation of the subcutaneous tissue.

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37

Tikhonova, I. V. "Age-dependent changes of oscillation processes of human skin microcirculation in normal and vascular pathologies." Regional blood circulation and microcirculation 17, no. 3 (September 30, 2018): 42–57. http://dx.doi.org/10.24884/1682-6655-2018-17-3-42-57.

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The review is devoted to the problems related to changes of the oscillation processes in the skin microvascular bed in human, which result from physiological aging. It is shown that both systemic (arterial hypertension) and local (chronic obstructive pulmonary disease and bronchial asthma) microcirculation disorders are reflected on cutaneous peripheral microhemodynamics. It is demonstrated that these diseases against the background of physiological aging of organism can lead to multidirectional changes of skin microcirculation parameters as compared with healthy subjects. It may be due to both local activation of the compensatory mechanisms with their subsequent influence on the skin microcirculation and adequate drug therapy.

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38

de la Garza-Castro, Oscar, Sandra Sánchez-González, Oscar DeLaGarza-Pineda, Abraham Espinosa-Uribe, Alejandro Quiroga-Garza, Rodrigo Elizondo-Omaña, and Santos Guzmán-López. "Dermatology Surgery Training in a Live Animal Model." Journal of Morphological Sciences 35, no. 03 (August 31, 2018): 187–90. http://dx.doi.org/10.1055/s-0038-1669904.

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Background Surgical technique is an important part of resident training, which is the reason why various models have been implemented to acquire this skill. Animal models have been useful in teaching dermatologic suturing techniques. With the advancements in technology, simulators have been developed for these exercises, but at a very high cost. The use of pig heads and freshly killed animals have proven to be effective and low-cost. However, they do not reproduce skin pathologies with accuracy. Objective To evaluate the effectiveness of a live anesthetized rat model to simulate skin pathologies requiring surgical excision in a dermatologic suture workshop for residents. Methods We analyze the outcome of a theoretical and practical suturing workshop using live Wistar rats with 13 dermatology residents. Results The residents showed an improvement in surgical maneuvers, suturing techniques, and in the use of surgical instruments (p < 0.01). Conclusion The model proposed in the present study was economic, easy to obtain and to manage, and it portrays live and accurate skin response to manipulation. Therefore, it is effective for conducting surgical training sessions in dermatology.

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Richter, JG, O. Sander, M. Schneider, and P. Klein-Weigel. "Diagnostic algorithm for Raynaud’s phenomenon and vascular skin lesions in systemic lupus erythematosus." Lupus 19, no. 9 (August 2010): 1087–95. http://dx.doi.org/10.1177/0961203310374304.

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Skin discolorations and skin lesions due to vascular pathologies are common clinical features in systemic lupus erythematosus. A variety of clinical manifestations such as Raynaud’s phenomenon, acrocyanosis, livedo patterns, erythematous or violaceous macules and papules or necrosis are triggered by heterogeneous pathophysiological mechanisms such as vasospasm, vasculitis or thromboembolism. A standardized macro- and microvascular assessment is necessary to establish the correct diagnosis. We describe and illustrate common clinical features of vascular skin manifestations in systemic lupus erythematosus and present a diagnostic algorithm. Lupus (2010) 19, 1087—1095.

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De Pessemier, Britta, Lynda Grine, Melanie Debaere, Aglaya Maes, Bernhard Paetzold, and Chris Callewaert. "Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions." Microorganisms 9, no. 2 (February 11, 2021): 353. http://dx.doi.org/10.3390/microorganisms9020353.

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The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.

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Mende, Klaus C., Theresa Krätzig, Malte Mohme, Manfred Westphal, and Sven O. Eicker. "Keyhole approaches to intradural pathologies." Neurosurgical Focus 43, no. 2 (August 2017): E5. http://dx.doi.org/10.3171/2017.5.focus17198.

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OBJECTIVESpinal tumors account for 2%–4% of all tumors of the central nervous system and can be intramedullary, intradural extramedullary, or extradural. In the past, wide approaches were used to obtain safe access to these tumors, as complete resection is the goal in treating most tumor entities. To reduce surgical complications due to large skin incisions and destabilizing laminectomies, minimally invasive approaches were established. In this study, the authors share their experience with mini-open approaches to intradural tumor pathologies.METHODSThe authors retrospectively reviewed cases involving patients with intramedullary and intradural extramedullary lesions treated between 2009 and 2016. They present their surgical mini-open approach to the spinal cord as well as unique characteristics, key steps, and postsurgical complications for specific tumor subgroups (meningioma, neuroma, and intramedullary tumors).RESULTSA total of 245 intradural tumors were surgically treated during the study period. Of these lesions, 151 were intradural extramedullary meningiomas (n = 79) or neuromas (n = 72). Nine (12.5%) of the neuromas were dumbbell neuromas. Ninety-four tumors were intramedullary. The mean age of the patients was 51.4 years, and 53.9% were female. The mean duration of follow-up was 46.0 months.All meningiomas and neuromas could be resected using a mini-open keyhole approach, but only 5.3% of the intramedullary lesions could be accessed using this technique. Of the 94 patients with intramedullary tumors, 76.6% required a laminotomy, 7.4% required a hemilaminectomy, and 10.6% required a 2-level laminectomy. Only 2 of the patients with intramedullary tumors needed stabilization for progressive cervical kyphosis during follow-up. None of the other patients developed spinal instability after undergoing surgery via the mini-open (keyhole/interlaminar) approach. There were significantly more surgery-associated complications in the large exposure group than in the patients treated with the mini-open approach (19.1% vs 9.6%, p < 0.01).CONCLUSIONSIntradural extramedullary and in selected cases intramedullary pathologies may safely be resected using a mini-open interlaminar approach. Avoiding laminectomy, laminotomy, and even hemilaminectomy preserves spinal stability and significantly reduces comorbidities, while still allowing for complete resection of these tumors.

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De Annunzio, Sarah Raquel, Natalia Caroline Silva Costa, Rafaela Dalbello Mezzina, Márcia A. S. Graminha, and Carla Raquel Fontana. "Chlorin, Phthalocyanine, and Porphyrin Types Derivatives in Phototreatment of Cutaneous Manifestations: A Review." International Journal of Molecular Sciences 20, no. 16 (August 8, 2019): 3861. http://dx.doi.org/10.3390/ijms20163861.

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Recent scientific research has shown the use of chlorin, phthalocyanines, and porphyrins derivatives as photosensitizers in photodynamic therapy in the treatment of various pathologies, including some of the major skin diseases. Thus, the main goal of this critical review is to catalog the papers that used these photosensitizers in the treatment of acne vulgaris, psoriasis, papillomavirus infections, cutaneous leishmaniasis, and skin rejuvenation, and to explore the photodynamic therapy mechanisms against these conditions alongside their clinical benefits.

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Horn, Martin, Olga Zbodakova, Petr Kasparek, Jaroslav Srp, Radka Haneckova, Martin Hradilek, Michael Mares, and Radislav Sedlacek. "Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models." Biological Chemistry 399, no. 9 (September 25, 2018): 1085–89. http://dx.doi.org/10.1515/hsz-2018-0116.

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AbstractKallikrein-related proteases (KLKs) play a critical role in epidermis physiology and have been implicated in skin pathologies such as Netherton syndrome. The contribution of individual KLKs to skin proteolysis is poorly understood. Monitoring of their activities in skin proteome is hampered by overlapping substrate specificities, and there is a need for novel assays. Here, we present a platform of selective and sensitive fluorogenic substrates and inhibitors for profiling KLK5, KLK7 and KLK14. These chemical tools were evaluated using recombinant KLKs and tissue from a unique set of mice deficient in eight combinations of KLKs and their natural regulator LEKTI.

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Demori, Ilaria, Zeinab El Rashed, Viola Corradino, Annamaria Catalano, Leila Rovegno, Linda Queirolo, Sebastiano Salvidio, et al. "Peptides for Skin Protection and Healing in Amphibians." Molecules 24, no. 2 (January 18, 2019): 347. http://dx.doi.org/10.3390/molecules24020347.

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Amphibian skin is not to be considered a mere tegument; it has a multitude of functions related to respiration, osmoregulation, and thermoregulation, thus allowing the individuals to survive and thrive in the terrestrial environment. Moreover, amphibian skin secretions are enriched with several peptides, which defend the skin from environmental and pathogenic insults and exert many other biological effects. In this work, the beneficial effects of amphibian skin peptides are reviewed, in particular their role in speeding up wound healing and in protection from oxidative stress and UV irradiation. A better understanding of why some species seem to resist several environmental insults can help to limit the ongoing amphibian decline through the development of appropriate strategies, particularly against pathologies such as viral and fungal infections.

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Sherendak, V. P., I. A. Bratchenko, O. O. Myakinin, P. N. Volkhin, Yu A. Khristoforova, A. A. Moryatov, A. S. Machikhin, V. E. Pozhar, S. G. Kozlov, and V. P. Zakharov. "Hyperspectral in vivo analysis of normal skin chromophores and visualization of oncological pathologies." Computer Optics 43, no. 4 (August 2019): 661–70. http://dx.doi.org/10.18287/2412-6179-2019-43-4-661-670.

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In the paper, we present test results of methods for the noninvasive diagnosis of skin neoplasms, based on the hyperspectral registration of images by using a camera with an acousto-optic tunable filter. For the identification of oncological pathologies, an integral spectral index has been proposed for a set of concentric regions around the source of neoplasm growth for the tissue sample under study. As well as taking account of changes in the spectral properties of the tissue, the introduced index indirectly takes into account classical ABCD dermatoscopic features: asymmetry, border irregularity, color diversity, and the tumor diameter. Results of training set separating are presented and the applicability of the proposed approaches to the clinical practice is shown.

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Borkow, Gadi, Richard C. Zatcoff, and Jeffrey Gabbay. "Reducing the risk of skin pathologies in diabetics by using copper impregnated socks." Medical Hypotheses 73, no. 6 (December 2009): 883–86. http://dx.doi.org/10.1016/j.mehy.2009.02.050.

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Zakharov, V. P., I. A. Bratchenko, Yu A. Khristoforova, and D. V. Kornilin. "Diagnostics of skin pathologies based on spectral analysis of backward and raman scattering." Optics and Spectroscopy 115, no. 2 (August 2013): 182–86. http://dx.doi.org/10.1134/s0030400x13080213.

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Watanabe, Kenji, Shuichi Shibuya, Yusuke Ozawa, Koutaro Yokote, and Takahiko Shimizu. "Superoxide Dismutase 1 Deficiency Causes Age-Related Skin Pathologies Accompanied by p53 Activation." Free Radical Biology and Medicine 76 (November 2014): S39. http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.465.

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Romero Heredia, Nathaly Alejandra, and Andrés Joaquín Guarnizo Chávez. "Psychocutaneous disorder due to university stress-A case study." Journal of Neurology & Stroke 12, no. 1 (January 21, 2022): 5–7. http://dx.doi.org/10.15406/jnsk.2022.12.00488.

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Psychocutaneous disorders, or allergies exacerbated by psychological factors in adults, are a group of dermatological diseases, where an underlying condition such as atopic dermatitis is triggered by psychological stressors, and whose diagnosis is made by clinical, questioning, and ruling out others most frequent skin pathologies. It is closely linked to certain triggering psychological factors, which can be stress or anxiety. The present article includes a case study of an undergraduate patient, with the classic symptoms of a skin allergy. However, her case undergoes diagnostic trials without revealing any apparent cause. By means of a more thorough anamnesis, the stress factors that produce the skin affectation are identifiable.

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Petruk, Ganna, Rita Del Giudice, Maria Manuela Rigano, and Daria Maria Monti. "Antioxidants from Plants Protect against Skin Photoaging." Oxidative Medicine and Cellular Longevity 2018 (August 2, 2018): 1–11. http://dx.doi.org/10.1155/2018/1454936.

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Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase in oxidative stress and thus in photoaging. Exogenous supplementation with dietary antioxidants and/or skin pretreatment with antioxidant-based lotions before sun exposure might be a winning strategy against age-related skin pathologies. In this context, plants produce many secondary metabolites to protect themselves from UV radiations and these compounds can also protect the skin from photoaging. Phenolic compounds, ascorbic acid and carotenoids, derived from different plant species, are able to protect the skin by preventing UV penetration, reducing inflammation and oxidative stress, and influencing several survival signalling pathways. In this review, we focus our attention on the double role of oxidants in cell metabolism and on environmental and xenobiotic agents involved in skin photoaging. Moreover, we discuss the protective role of dietary antioxidants from fruits and vegetables and report their antiaging properties related to the reduction of oxidative stress pathways.

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