Dissertations / Theses: 'SK'

1

Lopes, Raquel Vieira 1983. "Sk-splines de funções periódicas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/306562.

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Orientador: Sérgio Antonio Tozoni
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matemática Estatística e Computação Científica
Made available in DSpace on 2018-08-22T06:19:51Z (GMT). No. of bitstreams: 1 Lopes_RaquelVieira_M.pdf: 1141005 bytes, checksum: 8091e673668abab031630ae7fd1b7436 (MD5) Previous issue date: 2013
Resumo: Os sk-splines são uma generalização natural dos splines polinomiais, os quais foram introduzidos e tiveram sua teoria básica desenvolvida por Alexander Kushpel nos anos de 1983-1985. Estas funções são importantes em várias aplicações e seu espaço é gerado por translações discretas de uma única função núcleo. Neste trabalho, estudamos condições necessárias e suficientes para a existência e unicidade de sk-splines interpolantes de funções periódicas. Além disso, estudamos a aproximação de funções de determinadas classes por sk-splines nos espaços Lp. Como aplicação estudamos a aproximação de funções infinitamente diferenciáveis e finitamente diferenciáveis por sk- splines
Abstract: The sk-splines are a natural generalization of polynomial splines. They were introduced and their basic theory developed by Alexander Kushpel between 1983 and 1985. These functions are important in many applications and the space of sk-splines is the linear span of shifts of a single kernel K. In this work, we study necessary and sufficient conditions for the existence and uniqueness of sk-splines interpolants of periodic functions. Furthermore, we study the approximation in several classes of functions by sk-splines in the Lp spaces. As an application we study the approximation of infinitely and finitely differentiable functions by sk-splines
Mestrado
Matematica Aplicada
Mestra em Matemática Aplicada

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2

Pucci, Michael. "Restrukturalizace společnosti VÁHOSTAV - SK, a.s." Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-359150.

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The main objective of this work is to clarify and define causes, which led to decline of the Váhostav - SK, a. s., review completed reorganization of the company and give overall look on the reorganization possibilities in Slovakia, compared to the possibilities of reorganization in Czech Republic. The work is divided into theoretical and practical part. The theoretical part contains a brief look on the Bankruptcy and Restructuring Act in Slovakia, with the main focus being on the restructuring process. The practical part is divided into two parts, first one describes restructuring of Váhostav - SK, a. s. The second part contains a critical view on the Slovak Bankruptcy and Restructuring Act, which is compared to the Czech Insolvency Act, where the main focus is still on the process of reorganization.

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3

Bystedt, Rasmus. "Möjlig efterträdare till skolflygplan SK 60." Thesis, Försvarshögskolan, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-4757.

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The SK 60 Aircraft has been a workhorse for the Air Force’s training of future pilots since the late 1960s. The aging SK60 aircraft is going out of style, and the system has merely a few years of total running time left. A replacement for the SK 60 needs to be implemented in the coming years, and the Armes Forces Flying School has been commissioned to conduct flight tests on suitable replacement systems. This study will conduct a system analysis of two aircrafts mentioned in the Flying Schools report. The systems are mainly valued on their suitability as a replacement for the SK 60 from a training perspective. The systems are also valued based on the possibility of expanding the military utility of each system such as their ability to carry out attack operations. Based on the sample the Pilatus Aircraft PC -21 and BAE Systems Hawk MK 120 aircrafts were chosen for evaluation. The two planes are different yet comparable which makes them suitable for comparison in this study. Hawk MK 120 was deemed as the most suitable replacement for the SK 60. The MK 120 appeared as slightly more favorable than the PC-21 after valuation and appraisal, both from an educational point of view but also with regard to its ability for extended military purposes.

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4

Krátka, Barbora. "TRANSFORMACE PRŮMYSLOVÉHO AREÁLU V PARTIZÁNSKÉM (SK)." Master's thesis, Vysoké učení technické v Brně. Fakulta architektury, 2017. http://www.nusl.cz/ntk/nusl-316338.

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The content of this diploma thesis is an urban study with the architectural details of the former Bata Industrial Park in Partizánske, and a particular conversion program for the building. My goal was to find a suitable concept for converting building no. 61 with respect to the city, to the people living in it, and to reintegrate into the life of a building that is empty today, unused and dilapidated. The goal was not to forcefully fill the functions of the building, but in successive steps and phases to find a solution how to reuse the building and to point to the factory as a element of the city's foundation and also to highlight the unique architecture of the Baťa period.

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5

Bodlund, Per, and Roderik Elfström. "Intersport & Skiljebo SK : Ett vinnande samarbete?" Thesis, Mälardalen University, School of Sustainable Development of Society and Technology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-732.

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Sammanfattning

Seminariedatum: 2008-06-04

Nivå: Kandidatuppsats i företagsekonomi, 15 Högskolepoäng

Handledare: Claes Jonsson

Författare: Per Bodlund 1983 Roderik Elfström 1981

pbd04002@student.mdh.se rem03001@student.mdh.se Västerås Västerås

Nyckelord: Relationsmarknadsföring, engagemang, förtroende, kommunikation, relationer, lojalitet.

Titel: Intersport & Skiljebo SK. Ett vinnande samarbete?

Problem: Sponsring är en viktig marknadsföringskanal för näringslivet och en viktig inkomstkälla för det svenska föreningslivet. Det är därför viktigt att relationen mellan sponsor och sponsortagare fungerar och att sponsorerna får ut vad de förväntar sig av samarbetet. Intersport och Skiljebo SK (SSK) har sedan många år tillbaka ett sponsrings- och samarbetsavtal. Intersport sponsrar SSK med utrustning och pengar mot att de får agera som återförsäljare/leverantör till föreningen samt att de hoppas få föreningens medlemmar som lojala kunder. De vet i dagsläget inte det exakta resultatet av samarbetet och är intresserade av att ta reda på om föreningens medlemmar är lojala kunder hos dem. De vill också stärka relationen till föreningen och deras medlemmar. För att kunna ta reda på hur de kan stärka relationen till SSK och medlemmarna i föreningen måste undersökningen visa hur det ser ut idag.

Syfte: Syftet med undersökningen är att beskriva och analysera relationerna mellan Intersport, SSK och SSK:s medlemmar utifrån attributen kommunikation, förtroende och engagemang. Dessa tre attribut är mycket viktiga beståndsdelar i en relation. Vidare är syftet att ta reda på om samarbetet leder till en ömsesidig lojalitet mellan Intersport och SSK respektive en köplojalitet mellan Intersport och SSK:s medlemmar.

Metod: För att kunna beskriva och analysera relationerna och för att ta reda på om det finns en lojalitet används ett något annorlunda angreppssätt där vi frågade alla tre inblandade parter. Det är alltså en triad av relationer där varje relation undersöks utifrån ovan givna attribut. För att få fram svar på hur det förhåller sig i relationerna används intervjuer för Intersport och SSK. För att få fram SSK:s medlemmars åsikter görs en enkätundersökning.

Resultat: Undersökningen visar att det finns brister i relationerna och att köplojaliteten mellan SSK:s medlemmar och Intersport är lägre än förväntat. Den ömsesidiga lojaliteten mellan Intersport och SSK som förening är dock mycket hög.

Abstract

Date: 2008-06-04

Level: Bachelor thesis in business economics, 15 Swedish credits

Supervisor: Claes Jonsson

Authors: Per Bodlund Roderik Elfström

1983 Västerås 1981 Västerås

pbd04002@student.mdh.se rem03001@student.mdh.se

Keywords: Relationship marketing, commitment, trust, communication, connected relationship, loyalty.

Title: Intersport and Skiljebo SK. A winning collaboration?

Problem: Sponsorship is an important marketing channel for the business world and an important income source for the Swedish sports associations. It is therefore important that the relationship between the sponsor and the sponsorship receiver is working and that the sponsors get what they expects of the collaboration. Intersport and Skiljebo SK (SSK) has since many years back a sponsor and collaboration deal. Intersport is giving SSK club equipment and money so they in return can be the retailer and supplier to the club and their members. Intersport hope this collaboration will lead to loyal SSK customers. Intersport does not know the exact result of the collaboration so they are interested to found out if the club members are loyal customers or not. Intersport wants to strengthen the relationship with the club and their members. To be able to do this they have to found out, with the help of this research, how the situation looks today.

Purpose: The purpose with the research is to describe and analyze the relationships between Intersport, SSK club and their members on the basis of the three attributes communication, trust and commitment. These three attributes are all very important parts in a relationship. The purpose is also to found out if the collaboration is leading to a mutual loyalty between Intersport and SSK club and respectively a buying loyalty between Intersport and SSK club members.

Method: To be able to describe and analyze the relationships and to see if there is a loyalty, a rather unusual approach is used were, we ask all three involved parties. It is a triad of relationships where every relation is investigated on the basis of the before mentioned attributes. Interviews were done with Intersport and SSK club to get an answer how the relationship is working. A survey was done to see what opinion SSK club members had about the relationships.

Result: The research show that there are some flaws in the relationships and the buying loyalty between SSK members and Intersport is not as high as Intersport maybe expected. The mutual loyalty between Intersport and SSK club is however very high.

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6

Dukkipati, Saihari Shekar. "SK Channel Clustering in SOD1-G93A Motoneurons." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1464713486.

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7

Brejcha, Lukáš. "Ocenění sportovního klubu SK Slavia Praha a.s." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-197601.

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The purpose of my Master's Thesis is to determine the value of the SK Slavia Praha a.s. as of 30.06.2013. I focus on comparing differences between valuation of classical manufaturing company and valuation of sport club in theoretical part. I describe suitable methods for valuation of company and apparatus, that I chose to valuation of club of course in theoretical part. I use financial analysis to analyse main indicators, which affect the value of company in practical part. I use yield and property method for valuation. Property method is more meaningful due to the fact that company does not have profit in recent years. Sports club in the Czech Republic are not traded on stock market unfortunately, so we can't compare result with anything. On the other hand Slavia changed owners recenty unfortunately, so estimate value could be based on the price which current owner bought it, but this value is only for comparison, relative to situation which club was at that time.

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Hrubý, Petr. "Analýza práce s fanoušky SK DYNAMO České Budějovice." Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-192415.

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The aim of this thesis is to identify and analyse factors affecting the attendance of domestic football matches of SK Dynamo club České Budějovice. The main emphasis is placed on working with fans. The theoretical part relates to the topic and focuses on the determining factors of demand for sport events, the sport product theory and phenomenon of a fan. The practical part introduces the club SK Dynamo České Budějovice more closely and analyses individual factors affecting demand for the club's matches and defines the significance of these factors. A chapter on working with the fans follows. At first the elements of sport product are characterised and secondly the club marketing elements. The practical section chapters are underpinned by the results of a survey which was carried out among the fans of SK Dynamo České Budějovice. The discourse and conclusion summarize the analysed results, evaluates working with fans and last but not least outlines possible steps for improvements of attendance and working with club's fans.

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9

Uksila, Tommi, and Thomas Norman. "Bolagiseringens påverkan på elitfotbollen : Fallet Örebro SK Elitfotboll AB." Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27643.

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1967 tog svensk idrott beslutet att avskaffa amatörreglerna, vilket innebar att idrottare nu kunde ta emot pengar för sitt idrottsutövande. Det dröjde dock fram till slutet på 1980-talet innan svensk fotboll på allvar professionaliserades och där hela spelartrupper heltidsanställdes av fotbollsklubben. I och med TV:s och medias ökade inblandning och intresse i fotbollen har sporten kommersialiserats allt mer och idag kommer stora delar av fotbollsklubbars intäkter från TV, reklam och sponsring. 1999 tog Riksidrottsförbundet ett beslut som gav idrottsföreningar tillåtelse att starta ett aktiebolag (IdrottsAB) som arbetar jämsides med den ideella föreningen, dock med begränsningen att ägandet i aktiebolaget till 51 % måste innehas av den ideella föreningen och dess medlemmar. I svensk fotboll har trenden med IdrottsAB inte tagit den fart som först förutspåddes, med tre allsvenska klubbar 2012 som valt vägen att bolagisera verksamheten. En av dessa tre klubbar är Örebro SK som 2006 bildade ÖSK Elitfotboll AB efter att 2004 ha blivit tvångsnedflyttade till Superettan på grund av ett negativt eget kapital. Syftet med den här studien är att undersöka hur bolagiseringen har påverkat ÖSK, vilka för- och nackdelar som upplevs med IdrottsAB, om fokus på det ekonomiska tagit överhand, om bolagisering hotar det ideella engagemanget och vilka för- och nackdelar som ses med 51-procentsregeln. Denna studie drivs med en kvalitativ ansats där vi valt att intervjua fem personer med koppling till ÖSK. Respondenterna ansåg att den största anledningen till att klubben valde att bolagisera var dels att ett aktiebolag ger ett proffsigare intryck samt att reglerna som gäller för aktiebolag är betydligt tydligare än de som gäller för ideella föreningar. Detta är även de största fördelarna tillsammans med ett större fokus på marknadsintäkter. Delade meningar råder om huruvida momspliktigheten varit positiv eller negativ för klubben. Den stora nackdelen anses vara poliskostnader vid matcharrangemang som faktureras aktiebolag men inte ideella föreningar. Respondenterna påpekar att bolagiseringen varit betydelsefull för klubben, om beslutet inte tagits hade vägen tillbaka till Allsvenskan varit mycket längre. Vad gäller 51-procentsregeln råder det delade meningar om ett avskaffande av den vore positiv eller negativ för svensk fotbolls konkurrenskraft internationellt. Nyckelord: IdrottsAB, professionalisering, kommersialisering, 51-procenstregeln

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Giacomin, Paul R. "Understanding the mechanism of oxygen sensitivity of SK channels /." Title page and summary only, 2002. http://web4.library.adelaide.edu.au/theses/09SB/09SBg429.pdf.

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Orfali, Razan. "SK Channel Modulators as Drug Candidates and Pharmacological Tools." Chapman University Digital Commons, 2018. https://digitalcommons.chapman.edu/pharmaceutical_sciences_theses/1.

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The small- and intermediate-conductance Ca2+ activated K + (SK/IK) channels play a fundamental role in the regulation of neurons in the central nervous system. In animal models, SK/IK channel positive modulators have been shown to be effective in reducing the symptoms of neurological diseases such as ataxia. Ataxia is a lethal neurological rare disease characterized by lack of balance and incoordination of muscle movements, often as a result of cerebellar or spinocerebellar neurodegeneration. SK/IK channel modulators have been developed over the past few decades. Currently available modulators are often weak in potency. Lack of knowledge about the binding site for the compounds is the main reason hindering the development of more potent and effective therapeutics targeting SK channels. Dr. Zhang and his colleagues recently discovered the binding pocket for these positive modulators of SK/IK channels. This pocket is located at the interface between the channel and calmodulin. Dr. Zhang and his colleagues performed screening of a large number of compounds in silico, to find those fitting into the binding pocket. I performed electrophysiological recordings to evaluate the efficacy and the potency of these modulators on SK2 channels. We discovered a correlation between the total binding energy values calculated from the structures and the potencies determined from electrophysiological recording.

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Ferraro, T. "Cellular localisation and function of neuronal SK potassium channels." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445445/.

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In the central nervous system, small conductance calcium-activated potassium channels (SK) are important for the generation of the afterhyperpolarisation that follows single or trains of action potentials. Three SK channels have been cloned (SKI, SK2 and SK3), which are selectively blocked by the venom toxin apamin and present distinct pharmacological properties. The principal aim of this work is to investigate the subcellular distribution of SK2 and SK3 channels in neurones. For this purpose, antibodies directed against specific regions of SK2 and SK3 subunits were raised, purified and characterised. Immunohistochemistry on rat brain sections showed that the SK2 protein is localised in somatic and dendritic structures in various brain regions. SK3 immunoreactivity is mainly associated with fibers, but also with neuronal somata and dendrites. Intense SK3 expression was detected in the substantia nigra pars compacta, the locus coeruleus and the dorsal raphe. In these brain regions, the distribution of the channel was analysed in relation to monoamine- containing neurones, at two different developmental stages. In this work, I also report the characterization of a new SK2 variant, SK2-860, which differs from the SK2 subunit by having an extended amino terminus. Heterologous expression of this variant in primary neurones indicates that the majority of the protein is located in clusters distributed throughout the cytoplasm. Western blot analysis with the SK2 antibody and with a specific antibody for the new variant showed that SK2-860 subunit is expressed in the rat central nervous system. The distribution pattern of the SK2-860 in the rat brain largely overlaps the one observed for SK2. Finally, in the last part of this work, the molecular determinants responsible for the difference in apamin sensitivity among the different members of the SK channel family were investigated. The study showed that the extracellular loop that connects transmembrane segments S3 and S4 of SK channel a subunits significantly contributes to apamin sensitivity of SK2 channels.

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Fransson, Martin, and Kristin Nilsson. "Marknadsföringens roll inom ishockeyföreningar : En fallstudie på elitserielaget Södertälje SK." Thesis, University of Kalmar, Baltic Business School, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-198.

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Sports Marketing is a growing part in the world of sports today. Our main purpose of this paper was to analyze which role marketing plays for an ice hockey organization in the Swedish elite today. For this study we did a case study research on the Swedish team Södertälje Sportklubb, where we interviewed seven people. In addition to the people in the organizations we chose to interview two sport journalists. This research was made from an organizations point of view and all of the interviews were of qualitative character. We could in our analysis draw clear parallels from the empirical and theoretical data. We could analyze the importance of marketing for Södertälje SK and also some general conclusions for the Swedish Elitserien in ice hockey. In our end discussion we created a model that we called Ice hockey Organizations Moment 22, where we show how the marketing function for the Södertälje SK works, according to our opinion.

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Ro, Seungil. "SK channels : distribution, function and regulation in mouse colonic myocytes /." abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3090879.

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Gábor, Radek. "Aplikace elektroerozivního hloubení při technologii výroby vyměnitelných břitových destiček SK." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228099.

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Chu, Ka Man Emily. "Desensitisation of the CGRP receptor in SK-N-MC cells." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487319.

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Calcitonin gene-related peptide (CORP) and adrenomedullin (AM) are potent vasodilators that activate the calcitonin-like receptor complexed with one of three receptor activity modifying proteins (RAMP1 for CORP, RAMP 2/3 for AM). Desensitisation of these receptors was characterised in the human neuroblastoma SK-NMC cell line. Desensitisation was dose-dependent (ICso values: CORP, 2.92 x 10-7 M; AM, 1.08 x 10-7 M) and time-dependent, being maximal with a 2-hour agonist pretreatment. Inhibitor experiments showed that CORP-induced desensitisation was independent of protein kinase A (H-89) but was partially mediated by protein kinase C (OFI09203X). Lipid raft-mediated receptor endocytosis did not seem to contribute to signal attenuation (methyl-f3-cyclodextrin and filipin), but clathrin-mediated internalisation plays a role (sucrose). Stable overexpression of dominant-negative ORK2 or dynamin had no effect on desensitisation, suggesting that ORKs and dynamin are not involved. Unlabelled CORP competed 2-[12sI]iodohistidyllO-hCORP (ICso=1.97 x 10-10 M). 15% 12SI_CORP internalised after 10 min, 47% after 120 min. Receptor endocytosis was not blocked by lipid raft inhibitors but was significantly reduced by sucrose, in line with the hypothesis that its effect on desensitisation was due to inhibition of clathrin-mediated internalisation. Overexpression of dominant-negative ORK2 or Dyn 1 did not alter internalisation, suggesting that ORKs and dynamin are not involved. CORP receptor endocytosis was confirmed by confocal immunofluorescence microscopy and biotin internalisation. f3-arrestin 2-eYFP did not redistribute following CORP stimulation. Cells stably expressing short hairpin RNA against f3-arrestinl and/or 2 were generated. Maximum silencing of f3-arrestinl mRNA was 29.8%. 48.2% f3-arrestin2 mRNA knockdown was achieved, with possible reduction of protein. CORP receptor desensitisation was unchanged compared to wild-type cells, consistent with the hypothesis that f3-arrestin2 is not required. Taken together, the data demonstrate desensitisation of the SK-N-MC CORP and AM receptors. CORP receptor desensitises through a PKC-mediated mechanism involving internalisation via clathrin-coated vesicles.

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Moka, Nagaishwarya, Kelley cross, Marianne Brannon, Janet Lightner, Megan Dycus, William Stone, Victoria Palau, and Koyamangalath Krishnan. "Delta-tocotrienol and simvastatin induces differential cytotoxicity and synergy in BRAF wild-type SK-MEL-2 and mutant BRAF SK-MEL-28 melanoma cancer cells." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/215.

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Targeting the mutant BRAF and immunotherapy are new approaches to the treatment of metastatic malignant melanoma that has significantly improved survival but is associated with significant toxicity and cost. Potent and specific BRAF inhibitors like vemurafenib and dabrafenib are superior to chemotherapy in treatment of BRAF mutant melanomas which represent nearly 50% of all melanomas. A less toxic approach to treatment of malignant melanoma is hence appealing. Delta-tocotrienol (DT3), an unsaturated vitamin E isoform, and simvastatin, an HMG-CoA reductase inhibitor have been shown to have anti-neoplastic properties. We studied the effects of these chemicals in both BRAF-mutated SK-MEL-28 and BRAF-wild type SK-MEL-2 melanoma cells. MTS assays were used to analyze cytotoxicity. SK-MEL-28 and SK-MEL-2 cells were cultured in MEM media containing 10% serum and plated in 96-well culture plates for 48 hours then treated with DT3 (0-80 µM), simvastatin (0-10 µM), or a combination and dosed again at 72 hours. SK-MEL-28 and SK-MEL-2 cells were grown in 60 mm plates and treated with DT3 at concentrations of 30 µM, simvastatin at concentrations of 10 µM and combination of DT3 and simvastatin at concentrations of 10 µM and 2 µM. Cell were lysed with RIPPA buffer with protease and phosphatase inhibitor after 6 hours of treatment. Protein concentration of cell lysates was measured spectrophotometrically (GLO Max Multi+, Promega), using a BCA protein assay kit. The samples were run in SDS PAGE and blotted onto nitrocellulose membranes. Membranes were incubated with antibodies against Hsp 70 (Enzo Life Sciences, Farmingdale, NY), Hsp 90 (Santa Cruz, Dallas, TX), pS6 and pERK (Cell Signaling, Danvers, MA) and pAKT. Using MTS assay, we found that DT3 (IC50 75.2 μM) and simvastatin (IC50 8.3μM) have cytotoxic effects on melanoma cell line SK-MEL-2, but not on the SK-MEL-28 cells DT3 and simvastatin at the concentrations studied (10-80 μM DT3) and (0.625- 10 μM simvastatin). Further studies determined that simvastatin decreased expression of pS6, pERK on SK-MEL-2 and not DT3. However, these effects are different in SK-MEL-28 cells where there is only decrease in expression of pS6; treated SK-MEL-2 cells also show over-expression of Hsp70 suggestive of a rescue effect leading to lesser cytotoxic activity. The selective cytotoxicity observed in wild type BRAF melanoma cell lines by DT3 and simvastatin warrants further research into the potential therapeutic use of these drugs. A differential cytotoxicity is shown by DT3 and simvastatin in malignant melanoma cells with selective more potency in wild type BRAF melanoma compared to mutant BRAF melanoma cells. Further studies will be undertaken to dissect the mechanistic basis of this differential response.

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Hancock, Jane M. "Resolving the role of SK channel activation in the mouse heart." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627925.

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Atrial Fibrillation (AF) is the most common sustained arrhythmia, affecting approximately 1 % of the population. In its treatment, pharmacological inhibition of repolarising potassium channel currents prolongs the atrial action potential (AP) and refractoriness, but due to a lack of atrial-selectivity the majority of existing drugs can have unwanted proarrhythmic side effects in the ventricles. Small-conductance calcium-activated potassium (SK) channels have been proposed as a promising atrial-selective drug target. However, data in the field are controversial. Although some discrepancies may be due to species differences there are nevertheless direct contradictions. The aim of this study was to confirm the presence of SK channels in the mouse atrium and resolve their functional role in the mouse heart. Three subtypes of SK channels have been cloned (SKI, SK2 and SK3). The presence of SK2 protein in mouse atrial myocytes was confirmed using confocal immunofluorescence microscopy. Whole-cell patch-clamp recordings revealed an outward current in mouse atrial myocytes that was partially inhibited by the SK inhibitors apamin, UCLI684 or NS8593. The effect of NS8593 was unlike that of apamin or UCL1684. Furthermore, NS8593 blocked other heterologously expressed cardiac channels, indicating multichannel block. Apamin inhibited the current in atrial myocytes with an ICso of 118 pM, close to reported values for homomeric SK2 channels. UCLI684 prolonged the AP duration (APD) in isolated mouse atrial myocytes and in the intact atrium. However, UCLI684 prolonged APD significantly more than did apamin, suggesting that there is an apamin-insensitive population of SK channels activated during an action potential. Co-expression of SK2 and SK3 channels in HEK293 cells produced a current with a pharmacology that matched that observed during atrial action potentia Is, suggesting the presence of heteromeric SK2-SK3 channels. Finally, UCLI684 increased beat-to-beat variability in repolarisation raising the possibility that SK inhibition may be pro-arrhythmic.

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Montgomery, Jenna Rachel. "Functional properties of recombinant SK channels expressed in tsA-201 cells." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492617.

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Costamagna, Alejandra. "El lugar del deseo en los cuentos de Antonio Sk?rmeta." Tesis, Universidad de Chile, 2010. http://repositorio.uchile.cl/handle/2250/108643.

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Tesis para optar al grado de Mag?ster en Literatura
Partiendo de las aproximaciones cr?ticas que examinan el fen?meno literario en di?logo fecundo con sus condiciones de producci?n y consideran que las obras se inscriben ?a veces integr?ndose, a veces resistiendo? en el ?mbito cultural y social que las sostiene, este trabajo se propone explorar la obra cuent?stica de Antonio Sk?rmeta en el contexto de su producci?n inicial. Lo que interesa ac? es revisar la po?tica original y el gesto narrativo de un autor que escoge el cuento como un g?nero eficaz, provechoso y esencialmente comunicativo para producir, seg?n sus propios t?rminos, ?un momento intenso de humanidad?. Lejos de pensar en la literatura como un reflejo inmediato de la sociedad, la propuesta de esta investigaci?n apunta a conectar la obra de Sk?rmeta con aquella concepci?n del mundo que la encauza. Esto supone considerar la escritura como un trabajo transformativo plagado de referencias que, siguiendo a No? Jitrik, se adhiere a cierto ?instrumental ideol?gico que no por internalizado (modas, selectividad de temas o im?genes, etc.) es menos resultado de una previa existencia cultural?. Para Jitrik el acto de escritura ocurrir? siempre desde la ideolog?a. Y desde ella, entonces, tendr? lugar la elecci?n de las t?cnicas aptas para que el trabajo se realice adecuadamente. Los cuentos de Sk?rmeta, en ese sentido, hacen suya la visi?n del mundo propia de una juventud que respira y protagoniza una ?poca de tanto entusiasmo y apertura como incertidumbre hist?rica. En efecto, 1967 no s?lo fue el a?o del debut en la narrativa de este escritor chileno nacido en 1940, sino tambi?n un momento clim?tico en el desarrollo cultural de Occidente, marcado por las invocaciones de una juventud en emergencia. Durante la alborotada d?cada del sesenta, por decirlo as?, confluyeron las aguas de una riqu?sima corriente de sensibilidades que se manifestaron en lo que Susan Sontag designar?a entonces como una ?voracidad de entusiasmos?. Los cuentos que aqu? estudiaremos (en el tercer cap?tulo de esta investigaci?n) se alojan en la atm?sfera plena de estos cambios en la metr?poli, en la regi?n latinoamericana y en nuestro pa?s, lo que entre otras cosas implica una ruptura formal y de contenidos con la producci?n literaria inmediatamente previa, la de la generaci?n del cincuenta, marcada en gran medida por la sensibilidad de postguerra y el pesimismo que le sobrevino como una cortina de acero. Y en Chile y en nuestra literatura, adem?s, por la ruptura frente al anquilosado criollismo de los a?os treinta y cuarenta, vigente todav?a en las letras locales. Tal como apunta el cr?tico Jos? Promis, los autores del cincuenta fueron ?testigos del resquebrajamiento del espacio social en que estaban insertos?. Con marcado talante individualista, los j?venes escritores de aquellos a?os dieron cuenta de la angustia vital que los aquejaba a trav?s de im?genes apocal?pticas, de un mundo cerrado y sin salida, ?frente al cual la ?nica respuesta posible, o quiz?s la m?s f?cil de asumir, era el escepticismo?. En este contexto, tal vez la pieza clave de la ?poca haya sido el libro de cuentos La dif?cil juventud, de Claudio Giaconi, que a partir de los inquietantes versos de Nicanor Parra citados en el ep?grafe (?Me preguntaron que de d?nde ven?a/ Contest? que s?, que no ten?a planes determinados/ Contest? que no, que de ah? en adelante?) fij? las coordenadas de lo que Antonio Avaria denominar?a acertadamente ?la anatom?a de la abulia?. Pero si el temple an?mico imperante en estos cuentistas fue el del hast?o, la atm?sfera de la d?cada siguiente ?la que nos interesa revisar en este trabajo? ser? la opuesta y corresponder?, como ya dijimos, al horizonte hist?rico de buena parte del mundo occidental. El arrojo y la vitalidad, as? como el ?nimo comunitario, la incorporaci?n de la cultura popular y del habla de la calle, el ?nfasis en la cotidianeidad y la disposici?n al goce, marcar?n la ruta de los narradores del sesenta. Especialmente de los veintea?eros, como el propio Antonio Sk?rmeta y sus cong?neres de la llamada nov?sima generaci?n o generaci?n del postboom. M?s all? de las etiquetas, sin embargo, la mirada de estas obras no estar? puesta en el individuo pesaroso ni en su atormentada existencia, sino m?s bien en los movimientos de hombres y mujeres que nacen, viven, leen, comen, bailan, fornican, viajan y tambi?n mueren. Seres que se configuran como una pluralidad. Si Giaconi parafraseaba la idea de Tolstoi, cuestion?ndola, cuando dec?a que era necesario describir bien el alma de la propia aldea para ser universal, es posible admitir que la tendencia de la d?cada siguiente ser? regresar al cuerpo colectivo de esa misma aldea, a su atm?sfera extasiada que movilizar? tanto al individuo como a la sociedad en su conjunto, para ser todav?a m?s universales.

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21

Deng, Zhihui. "SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (SK) CHANNELS IN MAMMALIAN SPINAL MOTONEURONS." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1237821684.

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Jerresand, Daniel, and Mats Johansson. "Elitlicensen : En studie i fallet med Örebro SK och problematiken kring kontrollbalansräkningen." Thesis, Södertörn University College, School of Business Studies, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-143.

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För att skydda fotbollens rykte och anseende satte det europeiska fotbollsförbundet UEFA ekonomiska krav på de nationella fotbollsförbunden. Utfärdad av det Svenska Fotbollsförbundet infördes därför år 2001 den s.k. Elitlicensen i svensk fotboll, gällande Allsvenskan och Superettan för herrar samt Damallsvenskan.

Elitlicensen sätter ett antal krav på klubbarna, med största vikt på att det egna kapitalet i föreningen inte får vara negativt, och att påföljden om detta inte uppfylls blir att föreningen tvångsnedflyttas en division. Örebro SK blev den första allsvenska klubb som tvingades ned en division pga. negativt eget kapital. Beslutet var dock långt ifrån okomplicerat och Örebro SK överklagade fotbollsförbundets beslut i tre instanser men fick avslag av alla tre.

Syftet med den här uppsatsen är att studera hur Örebro SK, Licensnämnden, Riksidrottsnämnden och Appellationsnämnden gick tillväga när dom hanterade och gjorde sin bedömning i fallet med Örebro SK:s elitlicens. Vi vill med denna uppsats se vilka regler som finns tillgängliga och ifall dom i detta fall med Örebro SK i nämndernas beslut efterföljdes på ett korrekt sätt. Fanns det en grund i gällande regler för besluten eller handlade det om tolkningsfrågor där man lika gärna hade kunnat ge Örebro SK rätt? Resultatet av fallet kom att handla om tre huvudpunkter, sakkunnigheten i Appellationsnämnden, spelartruppens bokförda värde och en fjärrvärmeskuld till kommunen. Tolkningarna i dessa frågor skiljer sig mellan nämndernas beslut och det finns regelmässiga grunder som gör det möjligt att ta ställning för båda sidor i detta fall vilket bara bevisar exakt hur svårbedömt det här fallet var. Riksidrottsnämnden avslog Örebro SK:s överklagande och flyttade ner klubben till Superettan men den här rapporten visar att man lika gärna hade kunnat ge ÖSK rätt och därmed låtit dom fortsätta spela allsvensk fotboll. Det hade sannolikt lett till minst lika stora reaktioner och diskussioner som nu blev fallet, men en sak hade ändå varit säker.

Istället för ett allsvenskt lag med balanserad ekonomi i Superettan, hade vi idag haft ett allsvenskt lag med balanserad ekonomi i Allsvenskan. Är det inte det som det Svenska Fotbollsförbundet i slutändan strävar mot att ha?

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Johansson, Nylander Per, Sebastian Nilsen, and Pontus Röstlund. "Fotbollens intressenter En fallstudie av bolagiserade fotbollsklubbarna Djurgårdens IF och Örebro SK." Thesis, Örebro universitet, Handelshögskolan vid Örebro Universitet, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-44733.

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Brom, Josef. "Komparace marketingových strategií SK Dynamo České Budějovice a FK Olympie Týn nad Vltavou." Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-201576.

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This diploma thesis deals with sport marketing - specifically with marketing strategies comparison of professional and amateur football clubs. Forms of commercial communications are described and specifics of sport marketing as well, then there SK Dynamo České Budějovice and FK Olympie Týn nad Vltavou presented including their marketing strategies. In frame of this work there was performed survey focused on perception of the club among it's own fans. The results of the survey were also compared with results of survey from bachelor thesis of the same author - the aim was to assess the influence of amateur marketing department of FK Olympie Týn nad Vltavou on perception of the club.

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SOARES, Paula Roberta Otaviano. "Atividade Antiproliferativa de Benzaldeído Canfeno Tiossemicarbazonas em Células de Melanoma Humano (SK-MEL-37)." Universidade Federal de Goiás, 2008. http://repositorio.bc.ufg.br/tede/handle/tde/1274.

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Made available in DSpace on 2014-07-29T15:16:34Z (GMT). No. of bitstreams: 1 Mestrado Paula.pdf: 2508093 bytes, checksum: eaf6dc0cbce3c8dd66202b6bce9a4939 (MD5) Previous issue date: 2008-05-21
The thiosemicarbazones are chemical compounds of considerable scientific interest due to their important biological properties, such as antitumoral, antibacterial, antiviral, and antiprotozoal, among others. The studied compounds have the natural monoterpene camphene in the R4 position and the benzaldehyde in R2, with the substitution in the ring for different (R) groups, making this work unique. In this way, thirteen different compounds were derived from the benzaldehyde camphene thiosemicarbazone: camphene isotyiocyanate, camphene thiosemicarbazide, benzaldehyde camphene thiosemicarbazone, p-metyl benzaldehyde camphene thiosemicarbazone, p-methoxy benzaldehyde camphene thiosemicarbazone, o-chloro benzaldehyde camphene thiosecarbazone, m-chloro benzaldehyde camphene thiosemicarbazone, p-chloro-benzaldehyde camphene thiosemicarbazone, o-nitrobenzaldehyde camphene thiosemicarbazone, m-nitro- benzaldehyde camphene thiosemicarbazone, p-nitrobenzaldehyde camphene thiosemicarbazone, p-dimetylamino benzaldehyde camphene thiosemicarbazone and p-hydroxy benzaldehyde camphene thiosemicarbazone. The experiments were conducted in vitro using human melanoma cells (SK-Mel-37), because the melanoma is the most serious type of skin cancer due to its high possibility to metastasize and its resistance to the induction of apoptosis by antineoplastic drugs. We first performed a visual screening to observe if there was detachment of more than 85% of the total number of cells, after treatment with the sole concentration of 100 μM. Thus, six compounds were selected: benzaldehyde camphene thiosemicarbazone, m-chloro benzaldehyde camphene thiosemicarbazone, m-nitro-benzaldehyde camphene thiosemicarbazone, p-dimetylamino benzaldehyde camphene thiosemicarbazone, p-hydroxy benzaldehyde camphene thiosemicarbazone e p-methoxy benzaldehyde camphene thiosemicarbazone. The morphological analysis of the treated cells, by inverted phase contrast microscope and Giemsa stain, showed intense cellular vacuolization and nuclear fragmentation. In the cellular viability test, through the MTT colorimetric assay, the compounds showed IC50 (inhibitory concentration for 50% of the cells) values between 12, 84 μM and 32, 18 μM, which are bellow of those described in the literature for compounds with antineoplastic action. The analysis of nuclear fragmentation by fluorescence microscopy was performed by the incorporation of propidium iodide, and it was observed, at different time points, a progressive increase of cellular damage and a pronounced nuclear fragmentation after the cellular detachment. The analysis of the DNA fragmentation by agarose gel electrophoresis revealed that the unequivocal cytotoxic action of the compounds occurred by apoptosis. Our results showed that six compounds derived from the benzaldehyde camphene thiosemicarbazones had cytotoxic activity in human melanoma cells (SK-Mel-37) in vitro, and constitute potential candidates for future analysis aiming its therapeutic application.
As tiossemicarbazonas são compostos de considerável interesse científico devido às suas importantes propriedades biológicas, tais como antitumoral, antimicrobiana, antiviral, antiprotozoária, dentre outras. Os compostos estudados apresentam o monoterpeno natural canfeno na posição R4 e o benzaldeído em R2, com substituição no anel por diferentes grupos (R), o que confere ao presente trabalho um caráter inédito. Dessa forma, foram apresentados para este estudo onze diferentes compostos derivados de benzaldeído canfeno tiossemicarbazona: benzaldeído canfeno tiossecarbazona, p-metil benzaldeído canfeno tiossemicarbazona, p-metóxi benzaldeído canfeno tiossemicarbazona, o-cloro benzaldeído canfeno tiossemicarbazona, m-cloro benzaldeído canfeno tiossemicarbazona, p-cloro benzaldeído canfeno tiossemicarbazona, onitro benzaldeído canfeno tiossemicarbazona, m-nitro benzaldeído canfeno tiossemicarbazona, p-nitro benzaldeído canfeno tiossemicarbazona, p-dimetilamino benzaldeído canfeno tiossemicarbazona e p-hidróxi benzaldeído canfeno tiossemicarbazona, além de isotiocianato canfeno e canfeno tiossemicarbazida. Os experimentos foram realizados in vitro utilizando-se células de melanoma humano (SKMel- 37), visto que o melanoma é o tipo mais grave de câncer de pele devido à sua alta possibilidade de metástase e resistência à indução de apoptose por drogas antineoplásicas. Inicialmente, realizamos um screening visual observando-se o desprendimento de mais de 85% do total das células, após tratamento com a concentração única de 100 μM. Dessa análise, foram selecionados seis compostos: benzaldeído canfeno tiossemicarbazona, mcloro- benzaldeído canfeno tiossemicarbazona, m-nitro-benzaldeído canfeno tiossemicarbazona, p-dimetilamino-benzaldeído canfeno tiossemicarbazona, p-hidróxibenzaldeído canfeno tiossemicarbazona e p-metóxi benzaldeído canfeno tiossemicarbazona. A análise morfológica das células tratadas e coradas com Giemsa e observadas através de microscópio óptico invertido em contraste de fase demonstrou intensa vacuolização celular e fragmentação nuclear. Na análise da viabilidade celular, através do ensaio colorimétrico do MTT, os compostos apresentaram valores de IC50 (Concentração Inibitória para 50% das células) entre 12,84 μM e 32,18 μM, valores que se encontram abaixo do descrito na literatura para compostos com ação antineoplásica. A análise da fragmentação nuclear através de microscopia de fluorescência foi realizada pela incorporação de iodeto de propídio. Observamos, em diferentes tempos, o aumento progressivo dos danos celulares e a fragmentação nuclear pronunciada após o desprendimento das células. A análise de fragmentação de DNA por eletroforese em gel de agarose revelou de maneira inequívoca que a ação citotóxica observada ocorre por apoptose. Os resultados obtidos demonstraram que seis compostos derivados do benzaldeído canfeno tiossemicarbazonas apresentaram atividade citotóxica em células de melanoma humano (SK-Mel-37) in vitro, e são candidatos promissores para as análises futuras visando à sua aplicação terapêutica.

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Marie, Nicolas. "Mécanismes de régulation du récepteur opioi͏̈de delta humain dans le neuroblastome SK-N-BE." Paris 5, 2003. http://www.theses.fr/2003PA05P602.

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Les opiacés exogènes, telle la morphine sont à l'heure actuelle les analgésiques les plus puissants utilisés en thérapeutique. Cependant, leur utilisation prolongée induit une tolérance conduisant à augmenter les doses de médicament pour obtenir les mêmes effets pharmacologiques et donc augmente les risques d'effets secondaires comme la dépression respiratoire. Depuis plusieurs années, de nombreuses études semblent indiquer que la tolérance pourrait prendre naissance dans un phénomène cellulaire bien connu : la désensibilisation. Le travail de cette thèse a consisté à étudier les mécanismes mis en jeu lors de la désensibilisation du récepteur opioi͏̈de d humain exprimé de manière endogène dans le neuroblastome SK-N-BE, sous l'action de différents agonistes. En effet ce récepteur, au même titre que le récepteur m, est impliqué dans l'analgésie. Nous avons montré que : - le récepteur d subissait une désensibilisation rapide (de l'ordre de 90 % à 30 min de traitement) en présence des agonistes sélectifs (DPDPE, deltorphine I, AR-M1000390, SNC-80) comparée à celle (environ 40 % à 30 min) induite par des agonistes non sélectifs (étorphine, enképhalines) - dans le cas des agonistes sélectifs, à l'exception de l'AR-M1000390 qui ne provoque pas d'internalisation des récepteurs, les récepteurs d sont séquestrés puis dégradés dans les lysosomes alors qu'en présence des agonistes non sélectifs, la séquestration des récepteurs est suivie de leur recyclage - la désensibilisation des récepteurs d en présence d'étorphine met en jeu les PKC et la GRK2, alors que pour la DPDPE et la deltorphine I, ce sont plutôt des tyrosines kinases. Au vu de ces résultats, nous pouvons conclure : 1 - qu'il existe une désensibilisation différentielle du récepteur d, dépendant de la sélectivité de l'agoniste 2 - que c'est la destiné du récepteur internalisé qui joue un rôle dans sa désensibilisation, plutôt que l'internalisation elle-même 3 - que l'implication de différentes kinases serait responsable de cette désensibilisation différentielle
Opiates, such as morphine, are still the most powerful drugs in the management of pain. However, their chronic use induces tolerance, compelling to increase drug dose to obtain the same pharmacological effects and consequently raising the risk of adverse side effects, such as respiratory depression. As m-opioid receptors, d-opioid receptors are involved in analgesia and could participate to the development of tolerance. Accumulating evidence, indicate that tolerance could be initiated by a well-known cell process : desensitization. We conducted our study on the desensitization mechanisms of the human d-opioid receptor, endogenously expressed in the neuroblastoma SK-N-BE cells, activated by distinct opioid agonists. We demonstrated that : - d selective agonists (DPDPE, deltorphin I, SNC-80, AR-M1000390) induced a rapid desensitization (9̃0% for 30 min-pretreatment period) of d opioid receptor compared to non-selective agonists (etorphine, enkephalins) - selective agonists but AR-M1000390, that does not induce receptor sequestration, promoted internalization of d-opioid receptors followed by their degradation in the lysosomal compartment, whereas non-selective agonists induced mainly a recycling after internalization - etorphine-induced desensitization involves PKC and GRK2, while tyrosine kinases are required for desensitization produced by DPDPE and deltorphin. Conclusions : 1 - we demonstrated that d-opioid receptors undergo a differential desensitization, largely depending on the agonist selectivity 2 - the desensitization rate is rather depending on the fate of the opioid receptor, once internalized, than its sequestration from the plasma membrane 3 - the recruitment of different kinases would underlie the differential desensitization induced by selective and non selective agonist

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Lebrazi, Jamal. "Etude des effets des activateurs du plasminogène sur les fonctions plaquettaires : aspects fonctionnels et biochimiques." Paris 6, 1994. http://www.theses.fr/1994PA066817.

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Hörmann, Wolfgang, and Josef Leydold. "Generating Generalized Inverse Gaussian Random Variates." WU Vienna University of Economics and Business, 2013. http://epub.wu.ac.at/3784/1/Report123.pdf.

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The generalized inverse Gaussian distribution has become quite popular in financial engineering. The most popular random variate generator is due to Dagpunar (1989). It is an acceptance-rejection algorithm method based on the Ratio-of-uniforms method. However, it is not uniformly fast as it has a prohibitive large rejection constant when the distribution is close to the gamma distribution. Recently some papers have discussed universal methods that are suitable for this distribution. However, these methods require an expensive setup and are therefore not suitable for the varying parameter case which occurs in, e.g., Gibbs sampling. In this paper we analyze the performance of Dagpunar's algorithm and combine it with a new rejection method which ensures a uniformly fast generator. As its setup is rather short it is in particular suitable for the varying parameter case. (authors' abstract)
Series: Research Report Series / Department of Statistics and Mathematics

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Olivo, Valeria. "The role of Gq protein-coupled receptors and SK channels in synaptic NMDA receptor function." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.658068.

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SK channels are activated by a rise in intracellular [Ca2+] and are expressed in the postsynaptic density of dendritic spines of CAl pyramidal neurons in the hippocampus, where they are activated by Ca2+ influx through both NMDA receptors (NMDARs) and voltage-gated Ca channels. Activation of SK channels hyperpolarises spines, reducing the amplitude of EPSPs, and therefore increasing the Mg2+ block of NMDARs and the threshold for long-term potentiation (LTP) induction, It has been shown that activation of M1 muscarinic acethylcholine receptors enhances the NMDAR-mediated component of EPSPs by inhibiting of SK channels in a PKC-dependent manner. This study investigates the possibility that other Gq protein-coupled receptors in CAl pyramidal cells could inhibit SK channels by similar molecular pathways and thereby facilitate synaptic NMDAR function. Firstly, it was confirmed that muscarinic M1 receptor activation enhanced the NMDAR-mediated component of EPSPs by inhibiting SK2 channels in a PKCdependent manner. Subseq"uently, the ability of Gq protein-coupled metabotropic glutamate receptors to inhibit SK channels was examined. Activation of mGluRl receptors by DHPG enhanced the NMDAR-mediated component of EPSPs through inhibition of SK channels in a similar fashion to M1 receptors, but interestingly this occured in a PKC-independent manner. Finally, it was tested whether Gq coupled dopamine receptors could inhibit SK channels and enhance the NMDAR-mediated component of EPSPs. The putative D1-D2 heteromeric dopamine receptor agonist SKF83959 strongly inhibited SK channels and enhanced the NMDAR-mediated component of EPSPs. However, these effects were not blocked by D1 or D2 dopamine receptor antagonists and furthermore a broad spectrum dopamine reteptor agonist did not replicate the effect of SKF83959. These results are more consistent with an effect of . SKF83959 on SK channels that is independent of dopamine receptors.

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Bagdonaitė, Agnė. "Pacientų nuomonės ir lūkesčių įvertinimas apie UAB “SK IMPEKS „MEDICINOS DIAGNOSTIKOS CENTRE“ teikiamas reabilitacijos paslaugas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120607_133746-20297.

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Darbo tikslas. Įvertinti pacientų nuomonę ir lūkesčius apie UAB“Sk Impeks Medicinos Diagnostikos Centre“ teikiamas reabilitacijos paslaugas. Darbo uždaviniai.: 1. Įvertinti pacientų pasiskirstymą UAB ,,SK Impeks Medicinos diagnostikos centre” teikiamoms reabilitacijos paslaugoms. 2. Nustatyti pacientų vertinimus teikiamoms reabilitacijos paslaugoms pasirinktoje sveikatos priežiūros įstaigoje. 3. Įvertinti sveikatos priežiūros paslaugų kokybę ir prieinamumą, lojalumą pasirinktai sveikatos priežiūros įstaigai Tyrimo metodika. 2011 metais UAB“Sk Impeks Medicinos Diagnostikos Centre“ atlikta anoniminė 381 pacientų apklausa. Tyrimas atliktas 2011 metų lapkričio, gruodžio ir 2012 metų sausio mėnesiais. Pacientų apklausai sudaryta 36 klausimų anoniminė anketa. Tyrimo duomenų analizė atlikta naudojant statistinį duomenų analizės paketą SPSS 20.0. Rezultatai. Atliktame tyrime dalyvavo 338 pacientai: (31,9 proc.) (n =108 ) - vyrų, (68,0 proc.) (n =230 ) – moterų. Įvertinus apklaustųjų amžių nustatyta, jog skaitlingiausios buvo 25 – 44 metų (42,0 proc.) ir 19 – 24 metų (32,3 proc.) amžiaus grupės. 65 – 74 metų ir vyresnių, daugiau negu 75 metų amžiaus grupėse respondentų skaičius buvo beveik vienodas (6,4 proc.) ir (5,8 proc.) Pastebėta tendencija, kad vyrams buvo labai svarbi aukštesnė personalo kvalifikacija (30,5 proc.) ir tobulesnė įranga ir medžiagos (13,0 proc.) negu moterims. Moterų pasirinkime dominavo: malonesnis personalo bendravimas (28,6 proc.), pacientui skiriama... [toliau žr. visą tekstą]
Research objective. Assess patients opinions and expectations about „SK Impeks Medicinos Diagnostikos Centre“ provided rehabilitation services. Research tasks. 1) to analyze,,SK Impeks Medicinos Diagnostikos Centre“ provided rehabilitation services; 2) to assess health status of patients visiting ,,SK Impeks Medicinos Diagnostikos Centre“ according to their gender, age; 3) to assess patients‘ opinions and expectations regarding provision of rehabilitation services. Research methodology. During 2011 an anonymous survey of 381 patients from “SK Impeks Medicinos Diagnostikos Centre“ were conducted. Research has been conducted during November and December of 2011 as well as January of 2012. For patients‘ survey an anonymous questionnaire with 36 questions were used. Research data analysis was performed using statistical analisys package SPSS 20.0. Results. There were 338 patients participating in the study: (31,9 proc.) (n =108) – men, (68,0 proc.) (n =230) – women. Assesing the age of respondents the most were 25 – 44 years old (42,0 proc.) and 19 – 24 years old (32,3 proc.), age groups 65 – 74 years and 75 years and older were similar (6,4 proc.) and (5,8 proc.). It was noticed that for men compared to women high quality of personnel was very important (30,5 proc.) and better equipment and materials (13,0 proc.). Women mostly choose: stuff communication (28,6 proc.), time given to patients (7,0 proc.) and shorter visits waiting time (7,4 proc.). Assesing reposndents... [to full text]

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Wojdowski, Patrick Stephen 1971. "An X-ray spectroscopic study of the SMC X-1/Sk X-ray binary system." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85257.

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Caplinger, John N. "MematineHCI and Amino-Alkyl-Cyclohexanes (621,625) Inhibit HSV-1 in SK-N-SH Neuronal Cells." Youngstown State University / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1007757941.

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Muge, Rosemary. "Poverty, protest and sport : poaching in the East Midlands, c.1820-1900." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49161/.

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In the East Midlands counties of Derbyshire, Leicestershire and Nottinghamshire levels of poaching equalled or exceeded those in many counties which are thought of as prime poaching areas. Using principally Criminal Registers, Game Laws Returns to Parliament, and local newspapers of the period, this study shows that people poached from three motives: because they were poor; because poaching was a sport; and as a protest. Day and night poachers,including night poaching gangs frequently involved in affrays, pursued their activities undeterred by the efforts at prevention of the landowners, police and courts. Poaching here was predominantly for ground game and declined in the last quarter of the century, but continued to be a source of anger and frustration for game preservers and the authorities to the end of this period. The poaching war in these counties, waged in an area with large aristocratic estates but where extreme game preservation was viewed critically, was not perceived as impacting on law and order in general. This was unlike Lancashire, where the activities of poachers were regarded as being a threat to the fabric of society. The causes of these differences between the East Midlands and Lancashire were rooted in police practice, attitudes to game preservation, and differences in gentry sport and hunting.

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Ali, Sk Imran [Verfasser], and Sander van [Akademischer Betreuer] Smaalen. "Synthesis, Superstructure, Vacancy-Ordering of Intercalated Transition Metal Dichalcogenides / Sk Imran Ali. Betreuer: Sander van Smaalen." Bayreuth : Universität Bayreuth, 2014. http://d-nb.info/1061071936/34.

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Schmücker, Helmut. "Resonanzstruktur des Zerfalls D+-1tnS->K°SK°Sp+- [D S K S K S pi]." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967681405.

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36

Wilhelmy, Florian [Verfasser], and Carsten [Akademischer Betreuer] Culmsee. "Die Rolle der SK-Kanäle in alpha-Synuclein-aktivierter primärer Mikroglia / Florian Wilhelmy ; Betreuer: Carsten Culmsee." Marburg : Philipps-Universität Marburg, 2019. http://d-nb.info/1183909225/34.

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37

Andrade, Anderson Cleyton Ferreira de [Verfasser], and Günter [Akademischer Betreuer] Höglinger. "Die Aktivierung von SK-Kanälen in einem Parkinson-Zellmodell / Anderson Cleyton Ferreira de Andrade. Betreuer: Günter Höglinger." Marburg : Philipps-Universität Marburg, 2014. http://d-nb.info/1064097383/34.

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38

Nilsson, Hallgren Clara, and Moa Ström. ""Även jag kommer bli fri(sk) en vacker dag" : Tonårsflickors upplevelser av att leva med Anorexia nervosa." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16862.

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Bakgrund: Anorexia nervosa (AN) räknas idag till en av de allvarligaste psykiska störningar eftersom sjukdomen är förenad med allvarliga komplikationer. Vanligaste åldern för insjuknande är 14–19 år. Tonårsflickor med AN upplever nedsatt hälsa och välbefinnande samt ökat lidande. Sjuksköterskans roll vid AN syftar till att normalisera vikten samtidigt som tonårsflickorna påtalar en önskan om att sjuksköterskan ska inge stöd och motivation. Syfte: Att beskriva tonårsflickors upplevelser av att leva med Anorexia nervosa. Metod: Självbiografiska blogginlägg har analyserats utifrån en manifest kvalitativ innehållsanalys med en induktiv ansats. Resultat: I resultatet framkom fyra huvudkategorier som beskriver tonårsflickors upplevelser av att leva med AN. Dessa innefattar Att leva i ständig konflikt med sig själv, Att leva med en förändrad kropp, Känslan av psykisk påfrestning och dess konsekvenser samt Att vilja bli frisk och fri. Konklusion: Att möta tonårsflickor som lever med AN kan upplevas svårt och kan innebära en utmaning för sjuksköterskan. Vidare påvisas att tonårsflickors behov och önskemål inte överensstämmer med sjuksköterskans roll vid AN. Som sjuksköterska är det angeläget att se till tonårsflickors behov och önskemål för att kunna öka upplevelsen av hälsa och välbefinnande, lindra lidande samt främja tillfrisknande.
Background: Anorexia nervosa (AN) is considered one of the most serious mental disorders since the disease is associated with serious complications. The most common age for AN is 14–19 years. Teenage girls with AN experience impaired health and well-being and increased suffering. The nurse's role aims to normalize the bodyweight. Teenage girls needs support and motivation from the nurse. Aim: To describe teenage girls' experiences of living with Anorexia nervosa. Method: Autobiographical blog entries have been analyzed based on a manifest qualitative content analysis with an inductive approach. Results: The result revealed four main categories that include Living in constant conflict with oneself, Living with a changed body, The feeling of mental stress and its consequences and Wanting to be healthy and free. Conclusion: Meeting teenage girls who live with AN can be a difficult experience for the nurse. Furthermore, it is shown that the needs of teenage girls do not correspond to the nurse's role in AN. As a nurse, it is important to look at the needs of teenage girls in order to increase the experience of health and well-being, alleviate suffering and promote recovery.

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39

Allouche, Stéphane. "Le neuroblastome humain sk-n-be comme modele d'etude des recepteurs opioides : caracterisation des voies de transduction." Caen, 1998. http://www.theses.fr/1998CAEN2013.

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La desensibilisation des recepteurs opioides serait l'un des evenements impliques dans le developpement de la tolerance aux morphiniques. Jusqu'a present, ce phenomene a ete etudie a partir de modeles cellulaires simples exprimant une population plus ou moins homogene de recepteurs. Toutefois, en ce qui concerne les recepteurs opioides humains, il n'existe pas de modele adequat. Dans notre laboratoire, il a ete precedemment montre qu'un neuroblastome humain, la lignee sk-n-be, exprimait de facon endogene uniquement des recepteurs opioides , et plus precisement, les sous-types pharmacologiques 1 et 2. Dans l'optique d'utiliser cette lignee cellulaire comme modele d'etude de la desensibilisation, nous avons tout d'abord caracterise les voies de transduction de ces recepteurs puis determine le type de desensibilisation. La premiere partie de ce travail a consiste a determiner les voies de transduction de ces deux sous-types, a savoir l'interaction des recepteurs avec les proteines g et des effecteurs intracellulaires (adenylate cyclase, phospholipase c et ca#2#+). Nous avons observe que l'activation des proteines g# par les recepteurs opioides etait directement liee a la nature, alcaloide ou peptidique, des agonistes utilises. Quant aux effecteurs intracellulaires, ces recepteurs inhibent l'accumulation d'ampc par l'intermediaire d'une ou plusieurs proteines g sensibles a la toxine pertussique et declenchent une liberation de calcium a partir de stocks intracellulaires sensibles a la ryanodine. Ce dernier effet est independant de la production d'insp3, et s'il implique une proteine g, elle est insensible aux toxines pertussiques et choleriques. En ce qui concerne l'etude des deux sous-types pharmacologiques 1 et 2, ils presentent des caracteristiques de transduction similaires et sont codes par un seul messager, ce qui laisse supposer qu'ils correspondraient a une meme entite moleculaire possedant des sites de liaison distincts pour les agonistes 1 et 2 selectifs. Enfin, dans une deuxieme partie, l'etude de la desensibilisation de l'inhibition de l'accumulation d'ampc a revele une desensibilisation heterologue entre les recepteurs opioides , dopaminergiques d2 et 2-adrenergiques apres un traitement prolonge de deux heures. Cette lignee sk-n-be, modele original, apparait comme un bon modele pour l'etude des evenements cellulaires et moleculaires responsables de la desensibilisation des recepteurs opioides humains.

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40

HASBI, AHMED. "Mecanismes de desensibilisation et de resensibilisation des recepteurs opioides delta humains dans le neuroblastome sk-n-be." Caen, 1999. http://www.theses.fr/1999CAEN2013.

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Malgre la diversite des effets pharmacologiques des substances opioides, leur utilisation therapeutique reste liee principalement a leur effet analgesique puissant. Cependant, la tolerance et la dependance tant physique que psychique representent les deux contraintes majeures qui amenent a reduire leur utilisation clinique. Le but de l'ensemble des travaux, presentes dans cette these, est de faire une approche moleculaire des mecanismes qui sous-tendent l'apparition de la tolerance aux opioides, phenomene caracterise par l'obligation d'augmenter les doses pour retablir l'effet escompte. En effet, la tolerance aux substances opioides peut-etre consideree comme le reflet physiologique de ce que represente la desensibilisation des recepteurs sur le plan moleculaire, cette derniere etant caracterisee par une diminution de la reponse d'un effecteur intracellulaire a une stimulation chronique du recepteur. Apres avoir montre que la desensibilisation des recepteurs opioides delta humain, exprimes de facon naturelle par le neuroblastome sk-n-be, est heterologue avec les recepteurs dopaminergiques d2 et partiellement avec les recepteurs 2-adrenergiques, nous nous sommes interesses aux mecanismes moleculaires impliques dans cette desensibilisation. Nous montrons que le recepteur opioide delta humain est une phosphoproteine membranaire de 51 kda, dont le taux de phosphorylation augmente apres traitement par un agoniste opioide, l'etorphine. Cette phosphorylation, correlee a la desensibilisation du recepteur, impliquerait une kinase de la famille des grk (g-protein-coupled receptor kinase), et plus precisement la grk2. Cette phosphorylation, facteur declenchant la desensibilisation du recepteur, serait aussi a l'origine de l'internalisation (sequestration) de ce dernier par la voie de la clathrine. Nous montrons egalement que cette internalisation serait une etape importante permettant la dephosphorylation, le recyclage et la resensibilisation du recepteur opioide delta. A long-terme, cette internalisation devient irreversible, due probablement a une degradation du recepteur. Par ailleurs, nous montrons que la -arrestine-1 est la seule isoforme de la famille des arrestines presente dans notre modele d'etude, et qu'elle subit une translocation du cytosol vers la membrane, une fois le recepteur active. Ceci suggere l'intervention de cette proteine dans la desensibilisation et l'internalisation du recepteur opioide delta humain. Des resultats preliminaires montrent, par ailleurs, que ce recepteur est internalise sous forme dimerique.

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41

Abdulkareem, Zana Azeez. "SK potassium and TRPM7 ion channel role in CNS cell survival and breast cancer cell death decisions." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/80343/.

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Cell survival is modulated by a cocktail of ion channels engaging cell life and death decisions through controlling key cellular messages such as apoptosis and proliferation. Unnatural regulation of these processes results in various disorders, for example neurodegenerative diseases, as well as the cancers. Nowadays, these pathologies are affecting millions of people per year in the world. Potassium (K+) ion channels appear to play a potent role in such illnesses since they can control many cellular gates in cell physiology such as ionic homeostasis and signalling cascades. Amongst the K+ channels, small (SK1-3) and intermediate (SK4) conductance Ca2+-activated potassium ion channels have recently been shown to save cells, thereby protecting mitochondrial function which serves as a cell survival platform. In the case of other ion channels, for instance transient receptor potential melastatin 7 (TRPM7), it is also repeatedly stated that such membrane channels shows an impressive and differential role in excitable and non-excitable cell survival. This channel also modulates ionic homeostasis of crucial ions in cellular physiology such as Ca2+. This study reveals that central nervous system (CNS) and breast cancer cells differentially express SK1-4 ion channel subtypes, and their functional presence is pharmacologically confirmed, however, in most cases these results were further clarified through small interference RNA (siRNA) method. Similarly, functional TRPM7 channel expression in CNS cells is also confirmed. In the CNS, SK1-4 channel activation rescues neurons from oxidative stress, whereas, TRPM7 channel inhibition protects CNS cells from this hydrogen peroxide (H2O2) harmful effect, as well as hypoxia and apoptosis, so improving cell survival. Excitingly, SK1-4 channels differentially exist between wild-type and Huntington’s affected mouse striatal cells, where diseased cells lack SK1-3 channels, key players in action potential activity. Interestingly, SK2 or SK3 channel subtypes are also functionally expressed in breast cancer cells with various phenotypes. This study established that these ion channels are powerful agents in a survival role, in fact controlling growth through cross-talk with an apoptotic avenue “intrinsic pathway”. SK2 or SK3 channel activation enhances cell viability, while its inhibition dampens cell growth. It is very noteworthy that SK2 and SK3 channels are not expressed in non-tumorigenic breast cells. In brief, SK1-4 and TRPM7 molecules are clearly implicated in the survival of diverse cell types through an apoptotic route, indicating that these ionic regulators are promising targets in channelopathies related to cellular degeneration and growth.

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42

Passos, Débora Cristina Silva dos. "Ação biológica in vitro de tiossemicarbazonas derivadas de canfeno e limoneno em células de melanoma humano (SK-MEL-37)." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3426.

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Melanoma is a type of cancer that arises from melanocytes and is notoriously resistant to radiation and chemotherapy. The thiosemicarbazones are synthetic compounds with marked biological properties such as antibacterial, antiviral, antiprotozoal and antitumor and previous studies have demonstrated cytotoxic activity against the human melanoma cells, so in this study, we evaluated the antiproliferative activity, the enzymatic activity of Caspases 2, 3, 6, 8, 9, the effect on the cell cycle gene expression levels of caspases 2, 3, 6, 8, 9, Apaf-1 and microscopic morphological changes in human melanoma cells (SK -MEL-37) twenty one monoterpene derived from natural thiosemicarbazone (-) - camphene: camphene, benzaldehyde, benzophenone, menthone, ethyl pyruvate, p-nitroacetophenone, pchloroacetophenone, p-methoxyacetophenone, p-methylacetophenone, p fluoracetofenona-phidroxiacetofena, furan, 3-methoxy-4-hydroxybenzaldehyde, p-fluorbenzaldehyde, 2- hydroxybenzaldehyde, cinnamic aldehyde, thiophene-2-carboxaldehyde, 1-H-imidazole-4- carboxaldehyde, tiossemicaroazida and six montoterpeno natural R-(+)-limonene: benzaldehyde, thiosemicarbazide, o-nitro, m-nitro, p-nitro, p-hydroxy and p-dimethylamino. The values found for the inhibitory concentration for 50% of cells (IC50) were between 12 μM and 55 μM. The percentage of cells in phase and in phase G0/G1 decreased SG2 / M increased after forty-eight hours of incubation with benzaldehyde thio-camphene, limonene thio-benzaldehyde, m-nitro, p-hydroxy and thiosemicarbazide increased indicating that the growth inhibitory effect might be also due to arrest of cells at S-G2/M phase. We observed increased activity of caspase 3 (m-nitro thio-limonene), 6 (camphene thio-benzaldehyde and p-hydroxy thio-limonene) and 8 (thio-benzaldehyde limonene). Late apoptotic features were detected in 62% of cells treated with benzaldehyde thio-camphene and morphological changes typical of apoptosis were visualized by fluorescence microscopy and scanning electron microscopy (SEM) after treatment with benzaldehyde thio-camphene chosen due to their low IC50 value (12 mM). It was observed gene expression of caspases 2, 3, 6, 8 and Apaf-1 in cells treated with benzaldehyde thio-camphene indicating the participation of these enzymes in the anti-proliferative effect observed. Our results indicate that the thiosemicarbazones derivatives can inhibit proliferation, regulate cell cycle, induce apoptosis of human melanoma cells (SK-MEL-37) and could be an candidate for future preclinical in vivo studies.
O melanoma é um tipo de câncer que surge nos melanócitos e é notoriamente resistente à radioterapia e quimioterapia. As tiossemicarbazonas são compostos sintéticos com marcantes propriedades biológicas tais como antibacteriana, antiviral, antiprotozoária e antitumoral e em estudos anteriores demonstraram ação citotóxica frente à celulas de melanoma humano, por isso, neste estudo, foi avaliada a atividade anti-proliferativa, a atividade enzimática das caspases 2, 3, 6, 8, 9, o efeito no ciclo celular, os níveis de expressão gênica das caspases 2, 3, 6, 8, 9, Apaf-1 e as alterações morfológicas por microscopia em células de melanoma humano (SK-MEL-37) de vinte e uma tiossemicarbazonas derivadas do monoterpeno natural (-)- canfeno: canfeno, benzaldeído, benzofenona, mentona, etil piruvato, acetofenona, pnitroacetofenona, p-cloroacetofenona, p-metoxiacetofenona, p-metilacetofenona, pfluoracetofenona, p-hidroxiacetofena, furano, 3-metóxi-4-hidroxibenzaldeído, pfluorbenzaldeído, 2-hidroxibenzaldeído, aldeído cinâmico, tiofeno-2-carboxialdeído, 1-Himidazol- 4-carboxialdeído, tiossemicaroazida, bem como seis do montoterpeno natural R-(+)- limoneno: benzaldeído, tiossemicarbazida, o-nitro, m-nitro, p-nitro, p-dimetilamino e phidróxi . Os valores encontrados para a concentração inibitória para 50% das células (IC50) situaram-se entre 12 μM e 55 μM. A porcentagem de células na fase G0/G1diminuiu e na fase SG2/M aumentou após quarenta e oito horas de incubação com o benzaldeído tio-canfeno, benzaldeído tio-limoneno, m-nitro, p-hidróxi e tiossemicarbazida, indicando que o efeito antiproliferativo observado pode ser devido a uma interrupção das células na fase SG2/M. Observou-se uma maior atividade de caspase 3 (m-nitro tio-limoneno), 6 (benzaldeído tiocanfeno e p-hidróxi tio-limoneno) e 8 (benzaldeído tio-limoneno). Características apoptóticas tardias foram detectados em 62% das células tratadas com benzaldeído tio-canfeno e as alterações morfológicas típicas de processo de apoptose foram visualizadas através da microscopia de fluorescência e de microscopia eletrônica de varredura (MEV) após tratamento com o benzaldeído tio-canfeno escolhido devido ao seu baixo valor de IC50 (12 μM). Observou-se a expressão gênica das caspases 2, 3, 6, 8 e o apaf-1 nas células tratadas com benzaldeído tio-canfeno indicando a participação dessas enzimas no efeito antiproliferativo observado. Os resultados indicam que as tiossemicarbazonas derivadas de canfeno e limoneno podem inibir a proliferação celular, regular o ciclo celular e induzir apoptose nas células de melanoma humano (SK-MEL-37), portanto, podem ser considerados candidatos para futuros ensaios pré-clínico in vivo.

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43

Kye, Min-Jeong. "Regulation of small-conductance, calcium-activated potassium channels (SK) in mouse brain in response to aging and stress." [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/kye/kye.pdf.

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44

Asplund, Love. "Från amatörism till professionalism : en undersökning av organisationerna hos Västerås SK ocg Gideonsbergs IF efter amatörismens avskaffande 1967." Thesis, Mälardalen University, Department of Social Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-366.

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Syftet med undersökningen är att belysa hur två fotbollsföreningar i Västerås påverkats av amatörismens avskaffande 1967. Gideonsbergs IF (damer) och Västerås SK (herrar). Undersökningen har fokus på hur dessa föreningars organisation och budget förändrats i och med professionalismens införande i den svenska idrotten, samt hur föreningarna skaffat sponsorer. Dessutom påvisas de skillnader som funnits mellan föreningarna. Forskningsansatsen är kvalitativ och data har insamlats främst från de båda föreningarnas styrelseprotokoll men även genom en intervju med en person som varit anställd av båda föreningarna under den undersökta perioden. Resultatet blev att tydliga förändringar syntes inom båda föreningarnas budget och organisation efter amatörismens avskaffande. Omsättningen i föreningarna ökade och organisationerna effektiviserades. Likheter och skillnader mellan klubbarna redovisas även.

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45

Drake, W. M. "Desensitisation of calcitonin gene-related peptide of adrenomedullin receptors in vascular smooth muscle of SK-N-MC cells." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275192.

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Pearce, N. J. "Studies on the mechanism of organ selective receptor occupation by the synthetic thyromimetic SK and F L-94901." Thesis, University of London, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383708.

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47

Oliveira, Antonio Edinardo de. "Uma caracterizaÃÃo do produto Sk (cos θ) x Sn-k (sen θ) na esfera euclidiana S^ (n+1)." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11689.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico
Neste trabalho consideraremos hipersuperfÃcies n-dimensionais com curvaturas escalar constante na esfera unitÃria S^(n+1). Caracterizaremos as hipersuperfÃcies dadas por produtos de esferas, cuja dimensÃo Ã n, na esfera unitÃria S^(n+1) e mostraremos que existe vÃrias hipersuperfÃcies compactas com curvaturas escalar constante na esfera unitÃria S^(n+1) que nÃo sÃo congruentes entre si. Em particular, provaremos que se M Ã uma hipersuperfÃcie n-dimensional (n>3) completa, localmente conformemente plana com curvatura escalar constante n(n-1)r na esfera unitÃria S^(n+1), entÃo r Ã maior do que um valor prÃ-estabelecido e sÃo provados dois resultados, um envolvendo isometrias e o outro de existÃncia, quando r e S satisfazem determinadas condiÃÃes, onde S Ã o quadrado da norma se segunda forma fundamental de M.
In this paper we consider n-dimensional hypersurfaces with constant scalar curvature in the unit sphere S ^ (n +1). Characterize the hypersurfaces given by products of spheres whose size is n, the unit sphere S ^ (n +1) and show that there is more compact hypersurfaces with constant scalar curvature in the unit sphere S ^ (n +1) that are not congruent itself. In particular, prove that M is an n-dimensional hypersurface (n> 3) complete with buckle locally flat accordingly constant scalar n (n-1) on the unit sphere S r ^ (n +1) is greater than r a pre-established and two results are proven value, and the other one involving isometries of existence, when are S satisfy certain conditions, where S is the square of the standard is second fundamental form of M.

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Oliveira, Antônio Edinardo de. "Uma caracterização do produto Sk (cos θ) x Sn-k (sen θ) na esfera euclidiana S^ (n+1)." reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/8108.

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OLIVEIRA, Antônio Edinardo de. Uma caracterização do produto Sk (cos θ) x Sn-k (sen θ) na esfera euclidiana S^ (n+1). 2013. 63 f. Dissertação (Mestrado em Matemática) ) - Centro de Ciências, Universidade Federal do Ceará, Programa de Pós-Graduação em Matemática, Fortaleza, 2013.
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In this paper we consider n-dimensional hypersurfaces with constant scalar curvature in the unit sphere S ^ (n +1). Characterize the hypersurfaces given by products of spheres whose size is n, the unit sphere S ^ (n +1) and show that there is more compact hypersurfaces with constant scalar curvature in the unit sphere S ^ (n +1) that are not congruent itself. In particular, prove that M is an n-dimensional hypersurface (n> 3) complete with buckle locally flat accordingly constant scalar n (n-1) on the unit sphere S r ^ (n +1) is greater than r a pre-established and two results are proven value, and the other one involving isometries of existence, when are S satisfy certain conditions, where S is the square of the standard is second fundamental form of M.
Neste trabalho consideraremos hipersuperfícies n-dimensionais com curvaturas escalar constante na esfera unitária S^(n+1). Caracterizaremos as hipersuperfícies dadas por produtos de esferas, cuja dimensão é n, na esfera unitária S^(n+1) e mostraremos que existe várias hipersuperfícies compactas com curvaturas escalar constante na esfera unitária S^(n+1) que não são congruentes entre si. Em particular, provaremos que se M é uma hipersuperfície n-dimensional (n>3) completa, localmente conformemente plana com curvatura escalar constante n(n-1)r na esfera unitária S^(n+1), então r é maior do que um valor pré-estabelecido e são provados dois resultados, um envolvendo isometrias e o outro de existência, quando r e S satisfazem determinadas condições, onde S é o quadrado da norma se segunda forma fundamental de M.

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49

Gettová, Zuzana. "Bezpečnost práce a pracovní úrazy ve stavebnictví." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2017. http://www.nusl.cz/ntk/nusl-265492.

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The subject of this thesis was to compare injuries. First comparison accidents took place within the area of SK - NACE, their sources, and their causes in the Slovak Republic in the years 2012 - 2015. In the next step compared accidents within the area CZ - NACE, their sources, and causes in the Czech Republic in years 2011 - 2015. The last took place juxtaposition between the Slovak and Czech Republic.

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50

Gómez-Bofill, Walter. "Über einparametrische Optimierungsprobleme (spezielle Einbettungen) und einparametrische Variationsgleichungen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II, 1999. http://dx.doi.org/10.18452/14358.

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In dieser Arbeit werden zwei parametrische Aufgaben untersucht, Optimierungsprobleme und Variationsungleichungen. Beide Probleme werden unter der urspruenglich fuer einparametrische Optimierungsprobleme definierten Regularitaet im Sinne von Jongen, Jonker und Twilt betrachtet. Unter der oben genannten Regularitaet bezueglich Optimierungsproblemen werden zwei spezielle Einbettungen studiert. Ausgehend von der Kenntnis eines inneren Punktes des zulaessigen Bereiches eines Optimierungsproblems P wird eine Einbettung definiert, deren parametrische zulaessige Menge fuer t<1 in Inneren von P ist. Fuer t=0 ist die Loesung trivial und fuer t=1 wird das Problem P erzeugt. Die Erreichbarkeit des Parameterwertes t=1 bei der Benutzung von Kurvenverfolgungsverfahren mit Spruengen wird eroertert. Durch die Unterscheidung der verschiedenen Richtungen in t, in denen ein Rueckkehrpunkt auftreten kann, wird bewiesen, dass die genannte Methode erfolgreich ist (bei erfolgreichen Spruengen). Fuer diese Einbettung wird die Voraussetzung der Regularitaet untersucht und ein Rechtfertigungssatz bewiesen. Durchgefuehrt wird ein kurzer Vergleich mit einer aehnlichen Homotopie in der Literatur. Fuer die zweite untersuchte Einbettung (eine Penalty-Einbettung aus der Literatur) wird ein Satz zur Rechtfertigung der Regularitaetsvoraussetzung bewiesen. Die Regularitaet im Sinne von Jongen, Jonker und Twilt wird fuer den Fall von Variationsungleichungen definiert und die 5 Typen neu beschrieben. Die Unterschiede zu den Typen bei Optimierungsproblemen ergeben sich aus der Tatsache, dass die Symmetrie der Hessematrix der Lagrangefunktion bezueglich x verloren geht. Das erfordert die sorfaeltige Umformulierung einiger Bedingungen. Auss erdem musste bei den Beweisen der lokalen Eigenschaften (geometrische Struktur, Aenderung der charakteristischen Groessen) diese neue Situation beruecksichtigt werden. Ebenfalls wird der generische Charakter dieser Regularitaet nachgewiesen. Aussagen ueber die Existenz verbindender Kurven zwischen t=0 und t=1 unter der Voraussetzung der Regularitaet werden angefuehrt. Die gesamte Betrachtung der genannten Regularitaet fuer einparametrische Variationsungleichungen und die daraus resultierenden Schluss folgerungen liefern einen nuetzlichen Beitrag zur Untersuchung von Variationsungleichungen.
We consider two types of one-parametric problems: optimization problems and variational inequalities. Both are studied in relationship with the regularity approach due to Jongen, Jonker and Twilt (JJT-regularity), which was defined initially only for one-parametric optimization problems. The properties of two special embeddings are analysed under the assumption of JJT-regularity. Given an optimization problem P, the first embedding analysed is defined with use of an interior point of the feasible set. It holds for this embedding, that the parametric feasible set for tglobal approach. Statements concerning the existence of solution curves connecting problems (for instance t=0 and t=1) under the defined regularity are studied in the last section. The consideration of JJT-regularity for the case of variational inequalities is a new and usefull aspect for the study of this problem.

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