Journal articles on the topic 'Site enabling'

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1

Seeliger, Barbara, Michele Diana, Jelle P. Ruurda, Konstantinos M. Konstantinidis, Jacques Marescaux, and Lee L. Swanström. "Enabling single-site laparoscopy: the SPORT platform." Surgical Endoscopy 33, no. 11 (January 8, 2019): 3696–703. http://dx.doi.org/10.1007/s00464-018-06658-x.

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Shehab, Mohamed, Moonam Ko, and Hakim Touati. "Enabling cross-site interactions in social networks." Social Network Analysis and Mining 3, no. 1 (February 7, 2012): 93–106. http://dx.doi.org/10.1007/s13278-012-0051-2.

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Han, Ming-Jie, De-Cai Xiong, and Xin-Shan Ye. "Enabling Wittig reaction on site-specific protein modification." Chemical Communications 48, no. 90 (2012): 11079. http://dx.doi.org/10.1039/c2cc35738k.

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4

McMurry, Andrew J., Shawn N. Murphy, Douglas MacFadden, Griffin Weber, William W. Simons, John Orechia, Jonathan Bickel, et al. "SHRINE: Enabling Nationally Scalable Multi-Site Disease Studies." PLoS ONE 8, no. 3 (March 7, 2013): e55811. http://dx.doi.org/10.1371/journal.pone.0055811.

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Ney, Peter, Ian Smith, Gabriel Cadamuro, and Tadayoshi Kohno. "SeaGlass: Enabling City-Wide IMSI-Catcher Detection." Proceedings on Privacy Enhancing Technologies 2017, no. 3 (July 1, 2017): 39–56. http://dx.doi.org/10.1515/popets-2017-0027.

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Abstract Cell-site simulators, also known as IMSI-catchers and stingrays, are used around the world by governments and criminals to track and eavesdrop on cell phones. Despite extensive public debate surrounding their use, few hard facts about them are available. For example, the richest sources of information on U.S. government cell-site simulator usage are from anonymous leaks, public records requests, and court proceedings. This lack of concrete information and the difficulty of independently obtaining such information hampers the public discussion. To address this deficiency, we build, deploy, and evaluate SeaGlass, a city-wide cellsite simulator detection network. SeaGlass consists of sensors that measure and upload data on the cellular environment to find the signatures of portable cell-site simulators. SeaGlass sensors are designed to be robust, low-maintenance, and deployable in vehicles for long durations. The data they generate is used to learn a city’s network properties to find anomalies consistent with cell-site simulators. We installed SeaGlass sensors into 15 ridesharing vehicles across two cities, collecting two months of data in each city. Using this data, we evaluate the system and show how SeaGlass can be used to detect signatures of portable cell-site simulators. Finally, we evaluate our signature detection methods and discuss anomalies discovered in the data.
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Han, Ming-Jie, De-Cai Xiong, and Xin-Shan Ye. "ChemInform Abstract: Enabling Wittig Reaction on Site-Specific Protein Modification." ChemInform 44, no. 12 (March 14, 2013): no. http://dx.doi.org/10.1002/chin.201312194.

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Tudoran, Radu, Alexandru Costan, Olivier Nano, Ivo Santos, Hakan Soncu, and Gabriel Antoniu. "JetStream: Enabling high throughput live event streaming on multi-site clouds." Future Generation Computer Systems 54 (January 2016): 274–91. http://dx.doi.org/10.1016/j.future.2015.01.016.

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Robles, Omar, and Daniel Romo. "Chemo- and site-selective derivatizations of natural products enabling biological studies." Nat. Prod. Rep. 31, no. 3 (2014): 318–34. http://dx.doi.org/10.1039/c3np70087a.

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The direct chemo- and site-selective modification of native bioactive natural products (NP) for structure–activity relationship (SAR) studies and cellular probe synthesis has recently begun to be addressed (FG = functional group). This review highlights selected recent examples of these functionalization strategies, including those that simultaneously introduce a linker and reactive group (gray structure) for subsequent conjugation to reporter tags.
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Dixit, Saurav. "Analysing Enabling Factors Affecting the On-site Productivity in Indian Construction Industry." Periodica Polytechnica Architecture 49, no. 2 (November 27, 2018): 185–93. http://dx.doi.org/10.3311/ppar.12710.

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The growth in construction productivity is low and do not continue for a long span of time. The purpose of the present research paper is to analyse the factors affecting on-site construction productivity in Indian construction industry. The tools used for the analysis are reliability analysis to check the consistency of the data, Pearson correlation analysis to mathematically validate the factor analysis, and linear regression analysis to propose a framework of factors affecting construction productivity. The findings of the reliability analysis concludes that the all the factors having a value of more than 0.67, which is considered to be good for the study, and the findings of the study conclude that the most significant 3 attributes grouped in linear regression analysis change in scope (R2), revision in drawings (R15), and response to change orders (R3) having maximum impact over the construction productivity. The research paper attempts to provide an insight and better understanding of the factors affecting on-site construction productivity in India and the ways and means to control and improve construction productivity of construction projects."This paper is the revised version of the paper that has been published in the proceedings of the Creative Construction Conference 2018: Dixit, S., Mandal, S. N., Thanikal, J. V, & Saurabh, K. (2018). Critical Analysis of Factors Affecting the on-site Productivity in Indian Construction Industry, (July), 38–45. https://doi.org/10.3311/CCC2018-006"
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Guo, Manman, Fen Qiu, Yuxi Yuan, Ting Yu, Cailei Yuan, and Zhang-Hui Lu. "Active Site Engineering in CoP@NC/Graphene Heterostructures Enabling Enhanced Hydrogen Evolution." Inorganic Chemistry 60, no. 21 (October 14, 2021): 16761–68. http://dx.doi.org/10.1021/acs.inorgchem.1c02639.

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11

Nucci, Nathaniel V., Maxim Pometun, and A. Joshua Wand. "Enabling Site-Resolved Measurement of Hydration Water-Protein Interactions by Solution NMR." Biophysical Journal 98, no. 3 (January 2010): 175a. http://dx.doi.org/10.1016/j.bpj.2009.12.4217.

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Steffen, Wojtek, Fu Chong Ko, Jigar Patel, Victor Lyamichev, Thomas J. Albert, Jörg Benz, Markus G. Rudolph, et al. "Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins." Journal of Biological Chemistry 292, no. 38 (July 27, 2017): 15622–35. http://dx.doi.org/10.1074/jbc.m117.797811.

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Plessius, Raoul, Nicole Orth, Ivana Ivanović-Burmazović, Maxime A. Siegler, Joost N. H. Reek, and Jarl Ivar van der Vlugt. "Reversible multi-electron storage in dual-site redox-active supramolecular cages." Chemical Communications 55, no. 84 (2019): 12619–22. http://dx.doi.org/10.1039/c9cc07138e.

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Norris, Michael H., Yun Kang, Bruce Wilcox, and Tung T. Hoang. "Stable, Site-Specific Fluorescent Tagging Constructs Optimized for Burkholderia Species." Applied and Environmental Microbiology 76, no. 22 (September 17, 2010): 7635–40. http://dx.doi.org/10.1128/aem.01188-10.

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ABSTRACT Several vectors that facilitate stable fluorescent labeling of Burkholderia pseudomallei and Burkholderia thailandensis were constructed. These vectors combined the effectiveness of the mini-Tn7 site-specific transposition system with fluorescent proteins optimized for Burkholderia spp., enabling bacterial tracking during cellular infection.
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Hasnat, Mohammad A., Mohammed M. Rahman, Iqbal A. Siddiquey, S. M. Borhanuddin, M. Saiful Alam, M. Hamidur Rahman, and Abdullah M. Asiri. "Aggregated Pt–Pd nanoparticles on Nafion membrane for impulsive decomposition of hydrogen peroxide." RSC Advances 5, no. 57 (2015): 46295–300. http://dx.doi.org/10.1039/c5ra05620a.

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A Pd site initiates hydrogen peroxide decomposition by adsorbing one ‘O’ followed by splitting of O–H bond. Meanwhile, a Pt site finally completes the decomposition process by enabling desorption of the incipient O2 species.
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Schultz, Gregory M., Joe Keranen, Stephen Billings, John Foley, Raul Fonda, and Jerry Hodgson. "Integrated Methods for Marine Munitions Site Characterization: Technical Approaches and Recent Site Investigations." Marine Technology Society Journal 45, no. 6 (November 1, 2011): 47–61. http://dx.doi.org/10.4031/mtsj.45.6.7.

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AbstractInvestigation and remediation of munitions and explosives of concern (MEC) at marine sites are both time consuming and expensive. MEC assessment in marine environments has additional challenges compared to terrestrial sites, including the high cost of marine operations, the general absence of surface sweeps prior to geophysical assessments, the difficulty of quick or effective site reconnaissance activities, and high levels of clutter in ports, harbors, and bays. Consequently, a high payoff exists for effective methods of feature extraction and data fusion for improved assessment in marine settings. Recent site investigations have pointed to the potential of utilizing innovative geophysical sensing and new methods that directly link MEC experts to enabling technologies. We present two case studies to highlight the benefits of combining various technologies to provide the information needed for comprehensive munitions site characterization. This approach has been successful for both time-critical response activities and longer-term remedial investigations.
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Yu, Li, Gong Zhang, Chunlei Liu, Huachun Lan, Huijuan Liu, and Jiuhui Qu. "Site-specific surface tailoring for metal ion selectivity via under-coordinated structure engineering." Nanoscale Horizons 3, no. 6 (2018): 632–39. http://dx.doi.org/10.1039/c8nh00094h.

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18

Prasertying, Paithoon, Nanthatchaphon Jantawong, Thitaporn Sonsa-ard, Thinnapong Wongpakdee, Nuttamon Khoonrueng, Supatana Buking, and Duangjai Nacapricha. "Gold leaf electrochemical sensors: applications and nanostructure modification." Analyst 146, no. 5 (2021): 1579–89. http://dx.doi.org/10.1039/d0an02455d.

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19

Fletcher, Gena M., Timothy K. Behrens, and Lorie Domina. "Barriers and Enabling Factors for Work-Site Physical Activity Programs: A Qualitative Examination." Journal of Physical Activity and Health 5, no. 3 (May 2008): 418–29. http://dx.doi.org/10.1123/jpah.5.3.418.

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Background:Work sites offer a productive setting for physical activity (PA) promoting interventions. Still, PA participation remains low. Thus, the purpose of this study was to examine the reasoning behind commonly reported barriers and enabling factors to participation in PA programs in a work-site setting.Methods:Employees from a large city government were recruited to participate in focus groups, stratified by white- and blue-collar occupations. Responses from open-ended questions about factors influencing participation in PA programs were audio recorded and transcribed verbatim. Resulting data were analyzed with open and axial coding.Results:The sample consisted of 60 employees composing 9 focus groups. Although time was the most common barrier between both groups, white-collars workers responded that scheduling and work conflicts were the most common barrier concerning time. Blue-collar workers indicated shift work as their most common barrier. In addition, health was a significant enabling factor for both occupational categories. White-collar workers were much more concerned with appearances and were more highly motivated by weight loss and the hopefulness of quick results than were blue-collar workers.Conclusions:These findings are important in the understanding of PA as it relates to the reasoning behind participation in work-site programs in regard to occupational status.
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Robles, Omar, and Daniel Romo. "ChemInform Abstract: Chemo- and Site-Selective Derivatizations of Natural Products Enabling Biological Studies." ChemInform 45, no. 24 (June 2, 2014): no. http://dx.doi.org/10.1002/chin.201424267.

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Kopach, Olga, Kayiu Zheng, Olga A. Sindeeva, Meiyu Gai, Gleb B. Sukhorukov, and Dmitri A. Rusakov. "Polymer microchamber arrays for geometry-controlled drug release: a functional study in human cells of neuronal phenotype." Biomaterials Science 7, no. 6 (2019): 2358–71. http://dx.doi.org/10.1039/c8bm01499j.

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22

Sudomo, Aris, Dewi Maharani, Dila Swestiani, Gerhard E. Sabastian, James M. Roshetko, Aulia Perdana, Diana Prameswari, and Rizki A. Fambayun. "Intercropping Short Rotation Timber Species with Teak: Enabling Smallholder Silviculture Practices." Forests 12, no. 12 (December 13, 2021): 1761. http://dx.doi.org/10.3390/f12121761.

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Community forest management for timber production requires short- and long-rotation companion species to fulfill the demands of the timber industry, improve farmer welfare and maintain environmental sustainability. Four species (Falcataria moluccana, Neolamarckia cadamba, Acacia mangium and Gmelina arborea) were tested as short-rotation timber crop companion species for teak (Tectona grandis) on dry-rocky soil in the Gunungkidul community forest. The selection of short-rotation timber species was based on growth performance and survival rate at the teak site. Two years after planting, the viability of G. arborea (87.3%) and A. mangium (78.2%) was significantly (p < 0.05) higher than that of N. cadamba (40.6%) and F. moluccana (18.0%). G. arborea and N. cadamba achieved the best growth in terms of height, diameter, basal area, and volume, with the growth of A. mangium and F. moluccana being significantly inferior. Gmelina arborea has the ability to adapt to teak sites, grow well, and accompany teak. Neolamarckia cadamba demonstrated good growth with potential as a teak companion, and it demonstrated limited drought tolerance on the dry-rocky soils of the study sites. Acacia mangium had a high survival but produced slow growth, indicating that it required an advance evaluation in future years. Falcataria moluccana has different growing site requirements to teak so the performance was relatively poor at the study site. This mixed pattern provides benefits to farmers through commercial thinning of short rotations species, 5–8 years post establishment. Thinning operations will also increase the productivity of residual teak stands. The diversification of timber species in community forests can provide earlier returns, enabling the adoption of silviculture management by smallholders and communities.
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Smith, Robert William, Elaina Orlando, and Whitney Berta. "Enabling continuous learning and quality improvement in health care." International Journal of Health Care Quality Assurance 31, no. 6 (July 9, 2018): 587–99. http://dx.doi.org/10.1108/ijhcqa-10-2017-0198.

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Purpose The purpose of this paper is to examine how the design and implementation of learning models for performance management can foster continuous learning and quality improvement within a publicly funded, multi-site community hospital organization. Design/methodology/approach Niagara Health’s patient flow performance management system, a learning model, was studied over a 20-month period. A descriptive case study design guided the analysis of qualitative observational data and its synthesis with organizational learning theory literature. Emerging from this analysis were four propositions to inform the implementation of learning models and future research. Findings This performance management system was observed to enable: ongoing performance-related knowledge exchange by creating opportunities for routine social interaction; collective recognition and understanding of practice and performance patterns; relationship building, learning for improvement, and “higher order” learning through dialogue facilitated using humble inquiry; and, alignment of quality improvement efforts to organizational strategic objectives through a multi-level feedback/feed-forward communication structure. Research limitations/implications The single organization and descriptive study design may limit the generalizability of the findings and introduce confirmation bias. Future research should more comprehensively evaluate the impact of learning models on organizational learning processes and performance outcomes. Practical implications This study offers novel insight which may inform the design and implementation of learning models for performance management within and beyond the study site. Originality/value Few studies have examined the mechanics of performance management systems in relation to organizational learning theory and research. Broader adoption of learning models may be key to the development of continuously learning and improving health systems.
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Machovina, Melodie M., Sam J. B. Mallinson, Brandon C. Knott, Alexander W. Meyers, Marc Garcia-Borràs, Lintao Bu, Japheth E. Gado, et al. "Enabling microbial syringol conversion through structure-guided protein engineering." Proceedings of the National Academy of Sciences 116, no. 28 (June 24, 2019): 13970–76. http://dx.doi.org/10.1073/pnas.1820001116.

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Microbial conversion of aromatic compounds is an emerging and promising strategy for valorization of the plant biopolymer lignin. A critical and often rate-limiting reaction in aromatic catabolism isO-aryl-demethylation of the abundant aromatic methoxy groups in lignin to form diols, which enables subsequent oxidative aromatic ring-opening. Recently, a cytochrome P450 system, GcoAB, was discovered to demethylate guaiacol (2-methoxyphenol), which can be produced from coniferyl alcohol-derived lignin, to form catechol. However, native GcoAB has minimal ability to demethylate syringol (2,6-dimethoxyphenol), the analogous compound that can be produced from sinapyl alcohol-derived lignin. Despite the abundance of sinapyl alcohol-based lignin in plants, no pathway for syringol catabolism has been reported to date. Here we used structure-guided protein engineering to enable microbial syringol utilization with GcoAB. Specifically, a phenylalanine residue (GcoA-F169) interferes with the binding of syringol in the active site, and on mutation to smaller amino acids, efficient syringolO-demethylation is achieved. Crystallography indicates that syringol adopts a productive binding pose in the variant, which molecular dynamics simulations trace to the elimination of steric clash between the highly flexible side chain of GcoA-F169 and the additional methoxy group of syringol. Finally, we demonstrate in vivo syringol turnover inPseudomonas putidaKT2440 with the GcoA-F169A variant. Taken together, our findings highlight the significant potential and plasticity of cytochrome P450 aromaticO-demethylases in the biological conversion of lignin-derived aromatic compounds.
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Fernandes, Samantha, Cian Vyas, Peggy Lim, Rúben F. Pereira, Amaya Virós, and Paulo Bártolo. "3D Bioprinting: An Enabling Technology to Understand Melanoma." Cancers 14, no. 14 (July 20, 2022): 3535. http://dx.doi.org/10.3390/cancers14143535.

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Melanoma is a potentially fatal cancer with rising incidence over the last 50 years, associated with enhanced sun exposure and ultraviolet radiation. Its incidence is highest in people of European descent and the ageing population. There are multiple clinical and epidemiological variables affecting melanoma incidence and mortality, such as sex, ethnicity, UV exposure, anatomic site, and age. Although survival has improved in recent years due to advances in targeted and immunotherapies, new understanding of melanoma biology and disease progression is vital to improving clinical outcomes. Efforts to develop three-dimensional human skin equivalent models using biofabrication techniques, such as bioprinting, promise to deliver a better understanding of the complexity of melanoma and associated risk factors. These 3D skin models can be used as a platform for patient specific models and testing therapeutics.
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Golding, William A., and Robert J. Phipps. "Electrostatically-directed Pd-catalysis in combination with C–H activation: site-selective coupling of remote chlorides with fluoroarenes and fluoroheteroarenes." Chemical Science 11, no. 11 (2020): 3022–27. http://dx.doi.org/10.1039/d0sc00105h.

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Song, Zhaoying, Federico Tomasetto, Xiaoyun Niu, Wei Qi Yan, Jingmin Jiang, and Yanjie Li. "Enabling Breeding Selection for Biomass in Slash Pine Using UAV-Based Imaging." Plant Phenomics 2022 (April 22, 2022): 1–14. http://dx.doi.org/10.34133/2022/9783785.

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Traditional methods used to monitor the aboveground biomass (AGB) and belowground biomass (BGB) of slash pine (Pinus elliottii) rely on on-ground measurements, which are time- and cost-consuming and suited only for small spatial scales. In this paper, we successfully applied unmanned aerial vehicle (UAV) integrated with structure from motion (UAV-SfM) data to estimate the tree height, crown area (CA), AGB, and BGB of slash pine for in slash pine breeding plantations sites. The CA of each tree was segmented by using marker-controlled watershed segmentation with a treetop and a set of minimum three meters heights. Moreover, the genetic variation of these traits has been analyzed and employed to estimate heritability (h2). The results showed a promising correlation between UAV and ground truth data with a range of R2 from 0.58 to 0.85 at 70 m flying heights and a moderate estimate of h2 for all traits ranges from 0.13 to 0.47, where site influenced the h2 value of slash pine trees, where h2 in site 1 ranged from 0.13~0.25 lower than that in site 2 (range: 0.38~0.47). Similar genetic gains were obtained with both UAV and ground truth data; thus, breeding selection is still possible. The method described in this paper provides faster, more high-throughput, and more cost-effective UAV-SfM surveys to monitor a larger area of breeding plantations than traditional ground surveys while maintaining data accuracy.
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Fang, Ming, Wen-Bo Xu, Shun Han, Peijiang Cao, Wangying Xu, Deliang Zhu, Youming Lu, and Wenjun Liu. "Enhanced urea oxidization electrocatalysis on spinel cobalt oxide nanowires via on-site electrochemical defect engineering." Materials Chemistry Frontiers 5, no. 9 (2021): 3717–24. http://dx.doi.org/10.1039/d0qm01119c.

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A reversed-potential tuning strategy is proposed to introduce defects on the surface of cobalt oxide nanowires, enabling significantly improved electrocatalytic performance for urea oxidization under alkaline conditions.
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Pillow, Thomas H., Jack D. Sadowsky, Donglu Zhang, Shang-Fan Yu, Geoffrey Del Rosario, Keyang Xu, Jintang He, et al. "Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates." Chemical Science 8, no. 1 (2017): 366–70. http://dx.doi.org/10.1039/c6sc01831a.

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Zhong, Jieqiang, Yifan Huang, and Yehia Mechref. "Derivatization of Sialylated Glycopeptides (DOSG) Enabling Site-Specific Isomeric Profiling Using LC-MS/MS." Analytical Chemistry 93, no. 14 (March 31, 2021): 5763–72. http://dx.doi.org/10.1021/acs.analchem.0c05149.

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Trant, Jennifer. "Enabling Educational Use of Museum Digital Materials: The Museum Educational Site Licensing (MESL) Project." Art Documentation: Journal of the Art Libraries Society of North America 15, no. 2 (October 1996): 25–28. http://dx.doi.org/10.1086/adx.15.2.27948843.

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Sievers, Hans-Hinrich, Bartosz Rylski, Martin Czerny, Anna L. M. Baier, Maximilian Kreibich, Matthias Siepe, and Friedhelm Beyersdorf. "Aortic dissection reconsidered: type, entry site, malperfusion classification adding clarity and enabling outcome prediction." Interactive CardioVascular and Thoracic Surgery 30, no. 3 (November 22, 2019): 451–57. http://dx.doi.org/10.1093/icvts/ivz281.

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Abstract OBJECTIVES Aortic dissection is complex. Imaging and treatment modalities are evolving, demanding a more differentiated but pragmatic dissection classification. Our goal was to provide a new practical classification system including Type of dissection, location of the tear of the primary Entry and Malperfusion (TEM). METHODS We extended the Stanford dissection classification (A and B) by adding non-A non-B aortic dissection, the location of the primary entry tear (E) and malperfusion (M). A 0 was added if the primary entry tear was not visible; 1, if it was in the ascending aorta; 2, if it was in the arch; and 3, if it was in the descending aorta (E0, E1, E2, E3). We added 0 if malperfusion was absent; 1, if coronary arteries; 2, if supra-aortic vessels; and 3, if visceral/renal and/or a lower extremity was affected (M0, M1, M2, M3). Plus (+) was added if malperfusion was clinically present and minus (−) if it was a radiological finding. RESULTS The new classification system was analysed in 357 patients retrospectively; distribution was 59%, 31% and 10% for A, B and non-A non-B dissections. The in-hospital mortality rate was 16%, 5% and 8% (P = 0.01). Postoperative stroke occurred in 14%, 1% and 3% (P &lt; 0.001). The in-hospital mortality rate was 22%, 14%, 40% and 0% in A E0, E1, E2 and E3 (P = 0.023), respectively. Two years after the onset of dissection, the lowest survival rate was observed in A, followed by non-A non-B and B (83 ± 3% vs 88 ± 6% vs 93 ± 3%; P = 0.019). CONCLUSIONS The new practical TEM aortic dissection classification system adds clarity regarding the extent of the disease process, enhances awareness of the disease mechanism, aids in decision-making regarding the extent of repair and helps in anticipating outcome.
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Jin, Kang, Tianlu Li, Hoi Yee Chow, Han Liu, and Xuechen Li. "P−B Desulfurization: An Enabling Method for Protein Chemical Synthesis and Site-Specific Deuteration." Angewandte Chemie International Edition 56, no. 46 (October 18, 2017): 14607–11. http://dx.doi.org/10.1002/anie.201709097.

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Jin, Kang, Tianlu Li, Hoi Yee Chow, Han Liu, and Xuechen Li. "P−B Desulfurization: An Enabling Method for Protein Chemical Synthesis and Site-Specific Deuteration." Angewandte Chemie 129, no. 46 (October 18, 2017): 14799–803. http://dx.doi.org/10.1002/ange.201709097.

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Zung, Naama, and Maya Schuldiner. "New horizons in mitochondrial contact site research." Biological Chemistry 401, no. 6-7 (May 26, 2020): 793–809. http://dx.doi.org/10.1515/hsz-2020-0133.

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AbstractContact sites, areas where two organelles are held in close proximity through the action of molecular tethers, enable non-vesicular communication between compartments. Mitochondria have been center stage in the contact site field since the discovery of the first contact between mitochondria and the endoplasmic reticulum (ER) over 60 years ago. However, only now, in the last decade, has there been a burst of discoveries regarding contact site biology in general and mitochondrial contacts specifically. The number and types of characterized contacts increased dramatically, new molecular mechanisms enabling contact formation were discovered, additional unexpected functions for contacts were shown, and their roles in cellular and organismal physiology were emphasized. Here, we focus on mitochondria as we highlight the most recent developments, future goals and unresolved questions in the field.
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Suh, Sung-Eun, Leah E. Nkulu, Shishi Lin, Shane W. Krska, and Shannon S. Stahl. "Benzylic C–H isocyanation/amine coupling sequence enabling high-throughput synthesis of pharmaceutically relevant ureas." Chemical Science 12, no. 30 (2021): 10380–87. http://dx.doi.org/10.1039/d1sc02049h.

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A copper-based catalyst system composed of commercially available reagents enables C–H isocyanation with exquisite (hetero)benzylic site selectivity, enabling high-throughput access to pharmaceutically relevant ureas via coupling with amines.
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Schilter, David, Vladimir Pelmenschikov, Hongxin Wang, Florian Meier, Leland B. Gee, Yoshitaka Yoda, Martin Kaupp, Thomas B. Rauchfuss, and Stephen P. Cramer. "Synthesis and vibrational spectroscopy of 57Fe-labeled models of [NiFe] hydrogenase: first direct observation of a nickel–iron interaction." Chem. Commun. 50, no. 88 (2014): 13469–72. http://dx.doi.org/10.1039/c4cc04572f.

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Isotopically labelled Ni57Fe models of the [NiFe] hydrogenase active site have been prepared and studied with nuclear resonant vibrational spectroscopy, enabling direct characterization of metal–metal bonding.
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Baselga, Andrés, Alberto Jiménez-Valverde, and Gilles Niccolini. "A multiple-site similarity measure independent of richness." Biology Letters 3, no. 6 (October 9, 2007): 642–45. http://dx.doi.org/10.1098/rsbl.2007.0449.

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The Diserud–Ødegaard multiple-site similarity index makes use of data on species shared by two or more sites, but produces equal similarity values in two different circumstances: species loss and true species turnover. We developed a new multiple-site similarity measure, which is independent of richness and performs better than the Diserud–Ødegaard index under conditions of equal richness between sites, because it discriminates between situations in which shared species are distributed evenly among sites or concentrated in few pairs of sites. We conducted several simulations to assess the relative performance of both the indices. The use of the new measure is recommended, enabling the simultaneous analysis of turnover and richness gradients based on two independent measures.
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Matsuo, K., Y. Tanaka, L. F. G. Sarmenta, T. Nakai, and E. Bagarinao. "Enabling On-demand Real-time Functional MRI Analysis Using Grid Technology." Methods of Information in Medicine 44, no. 05 (2005): 665–73. http://dx.doi.org/10.1055/s-0038-1634023.

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Summary Objectives: The analysis of brain imaging data such as functional MRI often requires considerable computing resources, which in most cases are not readily available in many medical imaging facilities. This lack of computing power makes it difficult for researchers and medical practitioners alike to perform on-site analysis of the generated data. This paper presents a system that is capable of analyzing functional MRI data in real time with results available within seconds after data acquisition. Methods: The system employs remote computational servers to provide the necessary computing power. System integration is accomplished by an accompanying software package, which includes fMRI analysis tools, data transfer routines, and an easy-to-use graphical user interface. The remote analysis is transparent to the user as if all computations are performed locally. Results: The use of PC clusters in the analysis of fMRI data significantly improved the performance of the system. Simulation runs fully achieved real-time performance with a total processing time of 1.089 s per image volume (64 x 64 x 30 in size), much less than the per volume acquisition time set to 3.0 s. Conclusions: The results show the feasibility of using remote computational resources to enable on-demand real-time fMRI capabilities to imaging sites. It also offers the possibility of doing more intensive analysis even if the imaging site doesn’t have the necessary computing resources.
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40

Zheng, Yunan, Partha Sarathi Addy, Raja Mukherjee, and Abhishek Chatterjee. "Defining the current scope and limitations of dual noncanonical amino acid mutagenesis in mammalian cells." Chemical Science 8, no. 10 (2017): 7211–17. http://dx.doi.org/10.1039/c7sc02560b.

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We systematically evaluate potential platforms for site-specifically incorporating two distinct noncanonical amino acids into proteins expressed in mammalian cells with optimal fidelity and efficiency – a technology that will have many enabling applications.
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De Rosa, Lucia, Rossella Di Stasi, Alessandra Romanelli, and Luca Domenico D’Andrea. "Exploiting Protein N-Terminus for Site-Specific Bioconjugation." Molecules 26, no. 12 (June 9, 2021): 3521. http://dx.doi.org/10.3390/molecules26123521.

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Although a plethora of chemistries have been developed to selectively decorate protein molecules, novel strategies continue to be reported with the final aim of improving selectivity and mildness of the reaction conditions, preserve protein integrity, and fulfill all the increasing requirements of the modern applications of protein conjugates. The targeting of the protein N-terminal alpha-amine group appears a convenient solution to the issue, emerging as a useful and unique reactive site universally present in each protein molecule. Herein, we provide an updated overview of the methodologies developed until today to afford the selective modification of proteins through the targeting of the N-terminal alpha-amine. Chemical and enzymatic strategies enabling the selective labeling of the protein N-terminal alpha-amine group are described.
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42

Walsh, Stephen J., Soleilmane Omarjee, Warren R. J. D. Galloway, Terence T. L. Kwan, Hannah F. Sore, Jeremy S. Parker, Marko Hyvönen, Jason S. Carroll, and David R. Spring. "Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates." Chemical Science 10, no. 2 (2019): 633–34. http://dx.doi.org/10.1039/c8sc90248h.

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Correction for ‘A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates’ by Stephen J. Walsh et al., Chem. Sci., 2019, DOI: 10.1039/c8sc04645j.
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43

Michiyuki, Takuya, Itaru Osaka, and Kimihiro Komeyama. "Reductive amidation of alkyl tosylates with isocyanates by a Ni/Co-dual catalytic system." Chemical Communications 56, no. 8 (2020): 1247–50. http://dx.doi.org/10.1039/c9cc09377j.

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Reductive amidation of alkyl tosylates using a Ni/Co-dual catalytic system is disclosed. The method proceeds efficiently and can discriminate the steric environment of two tosylate moieties, enabling regioselective amidation at the less-bulky site.
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44

Doran, Glen H., David N. Dickel, and Lee A. Newsom. "A 7,290-Year-Old Bottle Gourd from the Windover Site, Florida." American Antiquity 55, no. 2 (April 1990): 354–60. http://dx.doi.org/10.2307/281653.

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A bottle gourd (Lagenaria siceraria) recovered from a burial context at the Windover site (8 BR246) in east-central Florida has been dated directly to 7,290 ± 120 radiocarbon years B.P. This provides the earliest documentation of bottle gourds north of Mexico and demonstrates approximate contemporaneity with other eastern United States Cucurbitacae. Investigations of wet sites such as Windover, while requiring substantially greater consideration of conservation than in typical dry sites, greatly expands the recovery of organic materials enabling broader insights to prehistoric processes.
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Zhao, Panxia, Jie Chen, Nana Ma, Jingfei Chen, Xiangquan Qin, Chuanfei Liu, Fuquan Yao, Lishan Yao, Longyi Jin, and Zhiqi Cong. "Enabling highly (R)-enantioselective epoxidation of styrene by engineering unique non-natural P450 peroxygenases." Chemical Science 12, no. 18 (2021): 6307–14. http://dx.doi.org/10.1039/d1sc00317h.

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H2O2-dependent epoxidation of unfunctionalized styrenes is achieved with high (R)-enantioselectivity and moderate to excellent TONs by combining site-mutated variants of cytochrome P450BM3 monooxygenase and a dual-functional small molecule (DFSM).
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Nikolakis, Nikolaos, Giannis Kantaris, Kyriakos Bourmpouchakis, and Kosmas Alexopoulos. "A cyber-physical system approach for enabling ventilation on-demand in an underground mining site." Procedia CIRP 97 (2021): 487–90. http://dx.doi.org/10.1016/j.procir.2020.05.265.

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47

Lopez, Marco A., Joshua A. Buss, and Shannon S. Stahl. "Cu-Catalyzed Site-Selective Benzylic Chlorination Enabling Net C–H Coupling with Oxidatively Sensitive Nucleophiles." Organic Letters 24, no. 2 (December 29, 2021): 597–601. http://dx.doi.org/10.1021/acs.orglett.1c04038.

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48

Jiang, Yiting, Zhengli Lu, Shengli Zou, Huagui Lai, Zhihao Zhang, Jincheng Luo, Yuanfang Huang, et al. "Dual-site passivation of tin-related defects enabling efficient lead-free tin perovskite solar cells." Nano Energy 103 (December 2022): 107818. http://dx.doi.org/10.1016/j.nanoen.2022.107818.

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49

Liu, Jun, Rujin Cheng, Ned Van Eps, Nanxi Wang, Takefumi Morizumi, Wei-Lin Ou, Paul C. Klauser, Sharon Rozovsky, Oliver P. Ernst, and Lei Wang. "Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents." Journal of the American Chemical Society 142, no. 40 (September 11, 2020): 17057–68. http://dx.doi.org/10.1021/jacs.0c06820.

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50

Liu, Meng, Yan-Fei Mu, Shuang Yao, Song Guo, Xiang-Wei Guo, Zhi-Ming Zhang, and Tong-Bu Lu. "Photosensitizing single-site metal−organic framework enabling visible-light-driven CO2 reduction for syngas production." Applied Catalysis B: Environmental 245 (May 2019): 496–501. http://dx.doi.org/10.1016/j.apcatb.2019.01.014.

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