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Academic literature on the topic 'Single-pa'

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Published: 1 April 2023

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Journal articles on the topic "Single-pa"

1

Abramov, V. V. "Single-spin asymmetry in pp and pA-collisions." Journal of Physics: Conference Series 678 (February 5, 2016): 012039. http://dx.doi.org/10.1088/1742-6596/678/1/012039.

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2

Lijnen, H. R., L. Nelles, B. Van Hoef, F. De Cock, and D. Collen. "Inhibition in Purified Systems and in Human Plasma of Chimaeric Plasminogen Activators Consisting of the NH2-Terminal Region of Tissue-Type Plasminogen Activator and the COOH-Terminal Region of UrokinaseType Plasminogen Activator." Thrombosis and Haemostasis 60, no. 02 (1988): 247–50. http://dx.doi.org/10.1055/s-0038-1647039.

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SummaryRecombinant chimaeric molecules between tissue-type plasminogen activator (t-PA) and single chain urokinase-type plasminogen activator (scu-PA) or two chain urokinase-type plasminogen activator (tcu-PA) have intact enzymatic properties of scu-PA or tcu-PA towards natural and synthetic substrates (Nelles et al., J Biol Chem 1987; 262: 10855-10862). In the present study, we have compared the reactivity with inhibitors of both the single chain and two chain variants of recombinant u-PA and two recombinant chimaeric molecules between t-PA and scu-PA (t-PA/u-PA-s: amino acids 1-263 of t-PA and 144-411 of u-PA; t-PA/u-PA-e: amino acids 1-274 of t-PA and 138-411 of u-PA). Incubation with human plasma in the absence of a fibrin clot for 3 h at 37° C at equipotent concentrations (50% clot lysis in 2 h), resulted in significant fibrinogen breakdown (to about 40% of the normal value) for all two chain molecules, but not for their single chain counterparts. Preincubation of the plasminogen activators with plasma for 3 h at 37° C, resulted in complete inhibition of the fibrinolytic potency of the two chain molecules but did not alter the potency of the single chain molecules. Inhibition of the two chain molecules occurred with a t½ of approximately 45 min. The two chain variants were inhibited by the synthetic urokinase inhibitor Glu-Gly-Arg-CH2CCl with apparent second-order rate constants of 8,000-10,000 M−1s−1, by purified α2-antiplasmin with second-order rate constants of about 300 M−1s−1, and by plasminogen activator inhibitor-1 (PAI-1) with second-order rate constants of approximately 2 × 107 M−1s−1.It is concluded that the reactivity of single chain and two chain forms of t-PA/u-PA chimaers with inhibitors is very similar to that of the single and two chain forms of intact u-PA.
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Lijnen, H. R., B. Van Hoet, F. De Cock, and D. Collen. "Effect of Fibrin-Like Stimulators on the Activation of Plasminogen by Tissue-Type Plasminogen Activator (t-PA) - Studies with Active Site Mutagenized Plasminogen and Plasmin Resistant t-PA." Thrombosis and Haemostasis 64, no. 01 (1990): 061–68. http://dx.doi.org/10.1055/s-0038-1647254.

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SummaryThe activation of plasminogen by t-PA was measured in the presence and absence of fibrin stimulation, using natural human plasminogen (nPlg) and rPlg-Ala740, a recombinant plasminogen with the active site Ser740 mutagenaed to Ala. Recombinant wild type t-PA (rt-PA) was used as well as rt-PA -Glul275, a recombinant single chain t-PA in which the Arg of the plasmin sensitiv e Arg275- Ile276 peptide bond was substituted with Glu. Conversion of 125I-labeled single chain plasminogen to two-chain plasmin by wild-type or mutant t-PA, was quantitated by SDS gel electrophoresis and radioisotope counting of gel slices, and expressed as initial activation rates (v0 in pM s−1) per 1 μM enzyme. In the absence of fibrin stimulation, the vs for the activation of nPlg and rPlg-Ala740 with the single chain forms of both t-PAs were comparable (0.6 to 2.7 pM s−1) but were lower than with the corresponding two-chain forms (5.3 to 23 pM s−1). In the presence of 1 μM soluble fibrin monomer (desAAfibrin), the v0 for nPlg and rPlg-Ala740 by single chain rt-PA was also comparable (24 and, 33 pM s-1 respectively), whereas with 1 pM CNBr-digested fibrinogen, the vs for nPlg with single chain rt-PA was about 20-fold higher than that of rPlg-Ala740 (135 and 7.5 pM s−1 respectively). In contrast, the vs for nPlg and rPlg-Ala740 by single chain rt-PA- G1u275, two-chain rt-PA-G1u275 or two-chain rt-PA were comparable in the presence of either desAAfibrin or CNBr-digested fibrinogen.These findings confirm and establish: 1) that single chain t-PA is an active enzyme both in the presence and absence of fibrin stimulator; 2) that, in a system devoid of plasmin activity (rPlg- Ala740), the two-chain form of t-PA is about L5 times more active than the single chain form in the absence of fibrin but equipotent in the presence of desAAfibrin; and 3) that the mechanism of stimulation of plasminogen activation with single chain t-PA by CNBr-digested fibrinogen is different from that by soluble fibrin.
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Holvoet, P., Y. Laroche, JM Stassen, HR Lijnen, B. Van Hoef, F. De Cock, A. Van Houtven, Y. Gansemans, G. Matthyssens, and D. Collen. "Pharmacokinetic and thrombolytic properties of chimeric plasminogen activators consisting of a single-chain Fv fragment of a fibrin- specific antibody fused to single-chain urokinase." Blood 81, no. 3 (February 1, 1993): 696–703. http://dx.doi.org/10.1182/blood.v81.3.696.696.

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Abstract The pharmacokinetic and thrombolytic properties were determined of two recombinant single-chain chimeric plasminogen activators (PA) consisting of u-PA-33k, a low-molecular weight derivative of single- chain urokinase-type PA (scu-PA) comprising amino acids Ala132 through Leu411, and of either a single-chain variable region fragment (Fv) derived from the fibrin fragment D-dimer-specific monoclonal antibody MA-15C5 (K12G0S32) or of the deglycosylated single-chain Fv fragment obtained by substitution of Asn88 with Glu (K12G2S32). Following bolus injection in hamsters, clearances of recombinant scu-PA (rscu-PA) and of K12G0S32 were similar. In contrast, clearance of K12G2S32 was fourfold slower than that of rscu-PA. The thrombolytic potency (percent lysis per u-PA administered in milligrams per kilogram body weight) and specific thrombolytic activity (percent lysis per microgram per milliliter steady-state plasma u-PA antigen level) of these compounds were studied in hamsters with an experimental pulmonary embolus consisting of a human plasma clot injected via the jugular vein. The doses of K12G0S32 and K12G2S32 required to obtain maximal rate of clot lysis were sixfold and 11-fold lower than that of rscu-PA. The steady- state u-PA-related plasma antigen levels of K12G0S32 and K12G2S32 required to obtain maximal rate of clot lysis were 10-fold and fourfold lower than that of rscu-PA. Thus, targeting of K12G0S32 to the clot surface by means of its glycosylated Fv fragment results in a 10-fold increase of its specific thrombolytic activity and sixfold increase of its thrombolytic potency as compared with those of rscu-PA. Targeting of K12G2S32 to the clot surface by means of its deglycosylated Fv fragment results in only a twofold increase of its thrombolytic activity. However, its fourfold slower clearance, combined with its twofold higher specific thrombolytic activity, results in an 11-fold increase of its thrombolytic potency over that of rscu-PA. These findings indicate that the thrombolytic potency of chimeric antibody- targeted PA may be increased by increasing the specific thrombolytic activity, reducing the clearance, or both.
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Holvoet, P., Y. Laroche, JM Stassen, HR Lijnen, B. Van Hoef, F. De Cock, A. Van Houtven, Y. Gansemans, G. Matthyssens, and D. Collen. "Pharmacokinetic and thrombolytic properties of chimeric plasminogen activators consisting of a single-chain Fv fragment of a fibrin- specific antibody fused to single-chain urokinase." Blood 81, no. 3 (February 1, 1993): 696–703. http://dx.doi.org/10.1182/blood.v81.3.696.bloodjournal813696.

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The pharmacokinetic and thrombolytic properties were determined of two recombinant single-chain chimeric plasminogen activators (PA) consisting of u-PA-33k, a low-molecular weight derivative of single- chain urokinase-type PA (scu-PA) comprising amino acids Ala132 through Leu411, and of either a single-chain variable region fragment (Fv) derived from the fibrin fragment D-dimer-specific monoclonal antibody MA-15C5 (K12G0S32) or of the deglycosylated single-chain Fv fragment obtained by substitution of Asn88 with Glu (K12G2S32). Following bolus injection in hamsters, clearances of recombinant scu-PA (rscu-PA) and of K12G0S32 were similar. In contrast, clearance of K12G2S32 was fourfold slower than that of rscu-PA. The thrombolytic potency (percent lysis per u-PA administered in milligrams per kilogram body weight) and specific thrombolytic activity (percent lysis per microgram per milliliter steady-state plasma u-PA antigen level) of these compounds were studied in hamsters with an experimental pulmonary embolus consisting of a human plasma clot injected via the jugular vein. The doses of K12G0S32 and K12G2S32 required to obtain maximal rate of clot lysis were sixfold and 11-fold lower than that of rscu-PA. The steady- state u-PA-related plasma antigen levels of K12G0S32 and K12G2S32 required to obtain maximal rate of clot lysis were 10-fold and fourfold lower than that of rscu-PA. Thus, targeting of K12G0S32 to the clot surface by means of its glycosylated Fv fragment results in a 10-fold increase of its specific thrombolytic activity and sixfold increase of its thrombolytic potency as compared with those of rscu-PA. Targeting of K12G2S32 to the clot surface by means of its deglycosylated Fv fragment results in only a twofold increase of its thrombolytic activity. However, its fourfold slower clearance, combined with its twofold higher specific thrombolytic activity, results in an 11-fold increase of its thrombolytic potency over that of rscu-PA. These findings indicate that the thrombolytic potency of chimeric antibody- targeted PA may be increased by increasing the specific thrombolytic activity, reducing the clearance, or both.
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Santos, Fávero G., Bernardo R. B. de A. Leite, and André A. Mariano. "A multimode CMOS PA with a single propagation path." Analog Integrated Circuits and Signal Processing 108, no. 2 (June 9, 2021): 421–35. http://dx.doi.org/10.1007/s10470-021-01886-z.

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7

Iacono, Teresa, and Linda Cupples. "Assessment of Phonemic Awareness and Word Reading Skills of People With Complex Communication Needs." Journal of Speech, Language, and Hearing Research 47, no. 2 (April 2004): 437–49. http://dx.doi.org/10.1044/1092-4388(2004/035).

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A series of phonemic awareness (PA) and single-word reading tasks, which did not require spoken responses, was developed for administration to people with complex communication needs. The aims of the study were to (a) determine the construct validity of the PA tasks and (b) investigate the relationship between PA and single-word reading in adults with complex communication needs. Forty adults with physical and/or intellectual disability were administered these tasks and a standardized measure of receptive spoken vocabulary. In assessing construct validity, data from all participants, including those who used speech, were included in a factor analysis, which indicated that the PA tasks loaded onto a single factor. This factor was interpreted to be PA. The relationship between PA and single-word reading in adults with complex communication needs was determined using correlational and multiple regression analyses of data from 34 of the original participants who did not have functional speech skills. These analyses indicated that receptive spoken vocabulary accounted for a significant amount of variance on most tasks. Additional significant variance in performance on the single-word reading tasks was accounted for by performance on the PA tasks, in particular, Nonword Blending and Phoneme Analysis. These results indicate that the tasks developed provide a valid means of assessing PA and single-word reading skills. In addition, the results indicate that adults with complex communication needs demonstrate the same positive association between PA and reading as has been found in other groups of individuals with and without disability.
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Fischer, B. E. "Comparison of the effects of fibrin binding on the biochemical properties of single-chain tissue-type plasminogen activator (t-PA) and single-chain chimeric plasminogen activator (t-PA/scu-PA)." Blood Coagulation & Fibrinolysis 3, no. 1 (February 1992): 39–46. http://dx.doi.org/10.1097/00001721-199202000-00007.

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9

Stump, DC, JM Stassen, E. Demarsin, and D. Collen. "Comparative thrombolytic properties of single-chain forms of urokinase- type plasminogen activator." Blood 69, no. 2 (February 1, 1987): 592–96. http://dx.doi.org/10.1182/blood.v69.2.592.592.

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Abstract The specific thrombolytic properties of urokinase and three molecular forms of single-chain urokinase-type plasminogen activator (scu-PA) were compared in a human plasma milieu in vitro and in an experimental thrombosis model in rabbits. These scu-PA molecules included Mr 54,000 scu-PA from human urine (urinary scu-PA), scu-PA from conditioned media of a human lung adenocarcinoma cell line (CALU-3,ATCC,HTB-55) (cellular scu-PA) and an Mr 32,000 proteolytic derivative of cellular scu-PA (scu- PA-32k). All four molecular forms induced significant lysis of a 125I- labeled human plasma clot immersed in citrated human plasma at concentrations between 50 and 200 IU/mL. None of the four showed absolute fibrin-specificity, but at equivalent lytic dose the three single-chain forms appeared to cause less fibrinogen degradation and alpha 2-antiplasmin consumption than two-chain urokinase. In addition, the fibrinolytic potential of the three single-chain forms was largely maintained during pre-incubation in plasma for up to 48 hours whereas that of urokinase was completely inhibited. Intravenous (IV) infusion of cellular scu-PA or scu-PA-32k into rabbits with a 125I-labeled thrombus in the jugular vein caused significant dose-dependent lysis at concentrations ranging from 8,700 to 35,000 and from 9,000 to 36,000 IU/kg respectively. Clot lysis was accompanied by minor alpha 2- antiplasmin consumption or fibrinogen breakdown. In contrast, urokinase induced lysis at doses between 20,000 and 200,000 IU/kg, but at higher doses was associated with significant systemic activation of the fibrinolytic system. It is concluded that scu-PA obtained from CALU-3 cell cultures has identical thrombolytic properties to that obtained from urine. In addition, the scu-PA-32k proteolytic derivative has the same fibrin-specific thrombolytic properties as the intact molecule. Cellular scu-PA and scu-PA-32k may therefore constitute more readily available alternatives for clot-selective thrombolytic therapy in man.
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Stump, DC, JM Stassen, E. Demarsin, and D. Collen. "Comparative thrombolytic properties of single-chain forms of urokinase- type plasminogen activator." Blood 69, no. 2 (February 1, 1987): 592–96. http://dx.doi.org/10.1182/blood.v69.2.592.bloodjournal692592.

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The specific thrombolytic properties of urokinase and three molecular forms of single-chain urokinase-type plasminogen activator (scu-PA) were compared in a human plasma milieu in vitro and in an experimental thrombosis model in rabbits. These scu-PA molecules included Mr 54,000 scu-PA from human urine (urinary scu-PA), scu-PA from conditioned media of a human lung adenocarcinoma cell line (CALU-3,ATCC,HTB-55) (cellular scu-PA) and an Mr 32,000 proteolytic derivative of cellular scu-PA (scu- PA-32k). All four molecular forms induced significant lysis of a 125I- labeled human plasma clot immersed in citrated human plasma at concentrations between 50 and 200 IU/mL. None of the four showed absolute fibrin-specificity, but at equivalent lytic dose the three single-chain forms appeared to cause less fibrinogen degradation and alpha 2-antiplasmin consumption than two-chain urokinase. In addition, the fibrinolytic potential of the three single-chain forms was largely maintained during pre-incubation in plasma for up to 48 hours whereas that of urokinase was completely inhibited. Intravenous (IV) infusion of cellular scu-PA or scu-PA-32k into rabbits with a 125I-labeled thrombus in the jugular vein caused significant dose-dependent lysis at concentrations ranging from 8,700 to 35,000 and from 9,000 to 36,000 IU/kg respectively. Clot lysis was accompanied by minor alpha 2- antiplasmin consumption or fibrinogen breakdown. In contrast, urokinase induced lysis at doses between 20,000 and 200,000 IU/kg, but at higher doses was associated with significant systemic activation of the fibrinolytic system. It is concluded that scu-PA obtained from CALU-3 cell cultures has identical thrombolytic properties to that obtained from urine. In addition, the scu-PA-32k proteolytic derivative has the same fibrin-specific thrombolytic properties as the intact molecule. Cellular scu-PA and scu-PA-32k may therefore constitute more readily available alternatives for clot-selective thrombolytic therapy in man.
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Dissertations / Theses on the topic "Single-pa"

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Strang, Christof. "The Effect of CO2-Pneumoperitoneum on Ventilation Perfusion Distribution of the Lung." Doctoral thesis, Uppsala universitet, Klinisk fysiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149746.

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Laparoscopic operations are a common and popular way for abdominal procedures. They are usually performed by insufflation of carbon dioxide (CO2) into the abdominal cavity. However, insufflation of CO2 may interfere with cardiac and circulatory as well as respiratory functions. The CO2-pneumoperitoneum (PP) may cause hypercarbia and acidosis. The direct effects of CO2 and acidosis lead to decreased cardiac contractility, sensitization of the myocardium to arrhythmogenic effects of catecholamines and systemic vasodilatation. There may even be long-lasting post-operative effects on breathing control. The pneumoperitoneum may also cause several respiratory changes, e.g. decreased functional residual capacity (FRC) and vital capacity (VC), formation of atelectasis, reduced respiratory compliance and increased airway pressure. Still, arterial oxygenation is mostly maintained or even improved during PP. In view of the apparently contradictory results in respiratory mechanics and gas exchange, the present studies were performed to evaluate respiratory changes on gas exchange and ventilation-perfusion distributions during PP in a porcine model. It was demonstrated that atelectasis during anaesthesia and PP may be estimated by an increased arterial to endtidal PCO2-gradient (study I). Perfusion was redistributed away from dorsal, collapsed lung regions when PP was established. This resulted in a better ventilation-perfusion match (study II). Increasing abdominal pressure shifted blood flow more and more away from collapsed lung tissue, decreased pulmonary shunt and improved oxygenation from 8 to 16 mmHg PP, despite an increase of atelectasis formation (study III). CO2-PP enhanced the shift of blood flow towards better ventilated parts of the lung compared to Air-PP. Moreover, sodium natriumprusside worsened the ventilation-perfusion match even more and blunted the effects previously seen with carbon dioxide. CO2 should therefore be the mediator of enhancing HPV during PP. In conclusion, pneumoperitoneum with CO2 causes atelectasis with elimination of ventilation in the dependent lung regions. However, an efficient shift of blood flow away from collapsed, non-ventilated regions results in a better ventilation-perfusion matching and better oxygenation of blood than without PP. A prerequisite for the beneficial effect is the use of carbon dioxide for the abdominal inflation, since it enhances HPV.
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Ben, mabrouk Mouna. "PA efficiency enhancement using digital linearization techniques in uplink cognitive radio systems." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0296/document.

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Pour un terminal mobile alimenté sur batterie, le rendement de l’amplificateur de puissance (AP) doit êtreoptimisé. Cette optimisation peut rendre non-linéaire la fonction d’amplification de l’AP. Pour compenser lesdistorsions introduites par le caractère non-linéaire de l’AP, un détecteur numérique fondé sur un modèle deVolterra peut être utilisé. Le comportement de l’AP et le canal étant modélisé par le modèle de Volterra, uneapproche par filtrage de Kalman (FK) permet d’estimer conjointement les noyaux de Volterra et les symbolestransmis. Dans ce travail, nous proposons de traiter cette problématique dans le cadre d’une liaison montantedans un contexte radio intelligente (RI). Dans ce cas, des contraintes supplémentaires doivent être prises encompte. En effet, étant donné que la RI peut changer de bande de fréquence de fonctionnement, les nonlinéaritésde l’AP peuvent varier en fonction du temps. Par conséquent, nous proposons de concevoir une postdistorsionnumérique fondée sur une modélisation par modèles multiples combinant plusieurs estimateurs àbase de FK. Les différents FK permettant de prendre en compte les différentes dynamiques du modèle.Ainsi, les variations temporelles des noyaux de Volterra peuvent être suivies tout en gardant des estimationsprécises lorsque ces noyaux sont statiques. Le cas d’un signal monoporteuse est adressé et validé par desrésultats de simulation. Enfin, la pertinence de l’approche proposée est confirmée par des mesures effectuéessur un AP large bande (300-3000) MHz
For a battery driven terminal, the power amplifier (PA) efficiency must be optimized. Consequently,non-linearities may appear at the PA output in the transmission chain. To compensatethese distortions, one solution consists in using a digital post-distorter based on aVolterra model of both the PA and the channel and a Kalman filter (KF) based algorithm tojointly estimate the Volterra kernels and the transmitted symbols. Here, we suggest addressingthis issue when dealing with uplink cognitive radio (CR) system. In this case, additionalconstraints must be taken into account. Since the CR terminal may switch from one subbandto another, the PA non-linearities may vary over time. Therefore, we propose to designa digital post-distorter based on an interacting multiple model combining various KF basedestimators using different model parameter dynamics. This makes it possible to track thetime variations of the Volterra kernels while keeping accurate estimates when those parametersare static. Furthermore, the single carrier case is addressed and validated by simulationresults. In addition, the relevance of the proposed approach is confirmed by measurementscarried on a (300-3000) MHz broadband PA
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Silva, Carlos Augusto Uchôa da. "Análise de precisão dos posicionamentos relativo e por ponto simples para bases curtas, com o sistema NAVSTAR/GPS: estudo de caso em Belém-PA." Universidade de São Paulo, 2000. http://www.teses.usp.br/teses/disponiveis/18/18137/tde-01032018-081755/.

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Este trabalho constitui-se num método para estudo, implantação e análise de precisão dos posicionamentos relativo e por ponto simples para vetores de linhas bases curtas com o GPS. Para isso, o autor elegeu, nomeou e observou com receptores GPS 21 pontos geodésicos na região metropolitana de Belém-PA, denominada de malha GPS99. Simultaneamente mediu dados meteorológicos \"in loco\" através de medições psicrométricas. As condutas organizadas para processamento dos dados diferem entre si em: tipos de correções inseridas e resultados analisados. Estes resultados são comparados entre si para a apresentação de análises, conclusões e recomendações acerca de diferentes fatores: PPP, L1 versus L3, Resolver ou fixar ambiguidade, inserir ou não variáveis meteorológicas reais para bases curtas, posicionamento relativo versus ponto simples, variação do ponto simples e influência da pressão atmosférica na precisão final de uma observação GPS. Adicionalmente é apresentada e discutida a metodologia PPP, desenvolvida pelo JPL.
The constitution of this work is a method for the study, introduction and analysis of precision of the relative positionings and for simple point to vectors of short base with the GPS. For this, the author elected, designated and observed with GPS receivers 21 geodesic points in the metropolitan region of Belém-PA, denominated of GPS99 net. Simultaneously methereological data were measured \"in loco\" through the psychometric measurements. The procedures to the data processing are different among them: types of inserted correction and analysed results. These results are compared among them to the presentation of analyse, conclusions and recommendations considering different factors: PPP L1 versus L3; solve of fix ambiguity insert or no real methereological variables to short base, relative positioning versus simple point, variation of the simple point and influence of atmospheric pressure into the final pressure of one GPS observation. Additionally the PPP methodology developed by JPL.
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Rashid, S. M. Shahriar. "Design and Heterogeneous Integration of Single and Dual Band Pulse Modulated Class E RF Power Amplifiers." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543505207173487.

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Hsiao-chuan, Peng，, and 彭筱娟. "The Study of Single Parent Children’s Counseling Process in PA Group." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/95386217809301137873.

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碩士
國立花蓮教育大學
國民教育研究所
94
The study aimed to explore the participation behaviors and adjustment process of the single parent’s children in PA (Project Adventure) Counseling Group at an elementary school in Hualien. Moreover, the PA and children’s condition in returning to their classes were discussed. Adhering to the qualitative research method, the researcher collected data from participation-observation, interviews, and related documents, which were then analyzed with the immersion/ crystallization approach. The following themes were the findings of the study. 1.Children’s behaviors and performance in PA Group All children’s common language and behaviors include interference, violence, imitation, and looking for support, etc. The single parent children were noticeable that they took more time opening their mind, and were more instable, cooperative, active and emulous. 2.The PA group educators’ practical knowledge It was necessary for the educators to enhance their self-reflective ability, knowledge of counseling, and empathy. More patience and proper guidance for the children were important. If coworkers could communicate in time, enhance their guidance ability and design the proper PA, the effect of counseling would increase. 3.Single parent children’s performance in their original classes After participating in PA Group in one semester, those single parent children could gradually behave well in their classes; especially the emotion control, self-affirmation and peer adaptation were enhanced.
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Lee, Wei-Ting, and 李威廷. "Research on 2.4-GHz CMOS Single-Mixer Transceiver/5-GHz PA RFIC and High-Q Spiral Inductor for Wireless Communication Applications." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/04887114348935771068.

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碩士
國立成功大學
電機工程學系碩博士班
92
This thesis presents the design and implementation of a 2.4-GHz CMOS single-mixer transceiver (TSMC 0.25�慆), a 5.7-GHz PA RFIC (TSMC 0.18�慆), and research on the high-Q spiral inductor for wireless communication applications. It is found that the CMOS planar spiral inductor shunting two metal layers exhibits a higher quality factor than that with a single metal layer. Although the two-layer spiral inductor has a higher parasitic capacitance, the self-resonant frequency and inductance are close to those of the single-layer spiral inductor. The 5.7-GHz CMOS three-stage class-A power amplifier (TSMC 0.18�慆) adopts the 3.3V high-voltage transistor to achieve the design specification. The PA exhibits a linear gain of 10.48dB, output P1dB of 15.95dBm, OIP3 of 25.11dBm and PAE of 11.37%. .The maximum allowable output power is 10.74dBm (data rate=54Mbps) The maximum allowable PA output power is 11.3, 10.2, 9.6 and 7.45dBm at the data rate of 24, 36, 48 and 54Mbps for the EVM measurement. The 2.4GHz CMOS transceiver RF front-end RFIC (TSMC 0.25�慆) consists of a LNA(with AGC), a series-type T/R switch and a PA with a diode-linearizer. The CMOS transceiver exhibits a gain of 12.9dB, noise figure of 5.7dB, input P1dB of –5.3dBm, IIP3 of 1.5dBm, gain tuning range of 12.93 to 2.24dB and noise figure tuning range of 5.7 to 10.35dB for the receiving mode. For the transmitting mode, the transceiver exhibits a linear gain of 28.0dB, output P1dB of 13.5dBm, OIP3 of 20.29dBm and PAE of 14.9%. The maximum allowable output power is 13.43dBm(data rate=11Mbps) for the IEEE 802.11b transmit spectrum mask test. The 2.4GHz CMOS single-mixer transceiver (TSMC 0.25�慆) integrates a T/R switch, a LNA, a passive switching mixer and a VCO into a single chip with the PA in a separated chip. The single-mixer transceiver architecture uses the same mixer in up- and down-conversion. The receiver exhibits a conversion gain of –0.13dB, noise figure of 6.16dB, input P1dB of –11.5dBm, IIP3 of –5.1dBm, gain tuning range of –0.13 to –15.13dB and noise figure tuning range of 6.16 to 18.35dB. The measured EVM and ACPR are all about 1.7% and –37dBc at the data rate of 1, 2, 5.5 and 11Mbps, respectively, for the IEEE 802.11b signal test. The transmitter exhibits a conversion gain of 14.8dB, output P1dB of 3.8dBm, OIP3 of 7.77dBm. The maximum allowable output power is 3.07dBm for the IEEE 802.11b transmit spectrum mask test (data rate = 11Mbps) with an EVM of 12.62% at an output power of 3.3dBm.
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7

李定原. "Research on “Zhao Wu Niang Pi Pa Ji” Compiled by Lai Bixia -------Form Hakka Chinese Narrative to single-port Hakka Opera of broadcast." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/cydx58.

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碩士
國立新竹教育大學
音樂學系碩士班
101
The creative ideas often match the products , but they changes a little because of external factors. Lai Bixia (hereafter referred to as ”Lai”)compiled “Zhao Wu Niang Pi Pa Ji” (hereafter referred to as ” Pi Pa Ji”)by tooking “Hakka Narrative” as the creative source. In the compiling process, Lai used ideas of Hakka songs, Holo songs and popular musics in Taiwan in that period to finish “Pi Pa Ji”, so we can get deep feelings not only of “Hakka Narrative” but also of “Hakka Opera” while appreciating it. The differences from“Pi Pa Ji” to “Hakka Opera” are they didn’t have body languages “Zuo” and “Da” when broadcast on the radio, Such changes on broadcasting media and playing style borned a new performance type, we can say it : “Hakka Opera of broadcast”. Further, there was only one player acted all the roles In a Opera show, so it could be called “Single-Port Hakka Opera of broadcast” better. This research is trying to set “Hakka Opera of broadcast” a proper position by three ways: scripts, tunes’ using and background music.
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Books on the topic "Single-pa"

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This side of married. New York: Viking, 2004.

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Pastan, Rachel. This side of married. New York: Penguin Books, 2005.

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1967-, Midal Fabrice, ed. Recalling Chogyam Trungpa. Boston, Mass: Shambhala, 2005.

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Leslie, Gould. Courting Cate. Thorndike, Maine: Center Point Large Print, 2013.

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Leslie, Gould. Courting Cate. Minneapolis, Minn: Bethany House, 2012.

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Blaise, Clark. Pittsburgh stories. Erin, Ont: Porcupine's Quill, 2001.

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Robards, Karen. Guilty. London: Hodder & Stoughton, 2008.

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Henry, DeWitt. The marriage of Anna Maye Potts: A novel. Knoxville: University of Tennessee Press, 2001.

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Robards, Karen. Guilty. Leicester: Charnwood, 2009.

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Wideman, John Edgar. Damballah. Boston: Houghton Mifflin, 1998.

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Book chapters on the topic "Single-pa"

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Declerck, P. J., H. R. Lijnen, and D. Collen. "Fibrin-specific Clot Lysis with Single Chain Urokinase-type Plasminogen Activator (scu-PA)." In New Trends in Haemostasis, 232–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-84318-1_21.

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VILLARREAL-SALAZAR, Angelly del Carmen, María Cristina ENRIQUEZ-REYNA, Perla Lizeth HERNÁNDEZ-CORTÉS, and Rosa Elena MEDINA-RODRÍGUEZ. "Assessment of physical activity, sedentary behaviors and physical fitness in perimenopausal women." In CIERMMI Women in Science Medicine and Health Sciences Handbooks T-XIII, 57–77. ECORFAN-Mexico, S.C., 2021. http://dx.doi.org/10.35429/h.2021.13.57.77.

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Introduction. Promoting active lifestyles to maintain physical functionality in middle-aged women implies field assessments which could sometimes be considered subjective or problematic. The proposal was to analyze physical activity, sedentary behaviors, and physical fitness in perimenopausal women living in the urban area of Monterrey. Methods. An analytical and descriptive study that includes comparative and association aspects with a single measurement. A personal data form was applied, as well as accelerometry with an ActiGraph GT3X+ movement detector, the AMAI Socioeconomic Level Questionnaire, the Sedentary Behavior Questionnaire, and the International Physical Activity Questionnaire (IPAQ)-Long Form. Physical fitness was assessed in relation to strength in the upper limbs (dynamometry) and lower limbs (30 second Sit to Stand Test) in addition to balance (Unipedal Stance Test). Data analysis was performed with the SPPS software, version 21.0; with descriptive and inferential statistics considering a critical value of 0.05 for Cronbach's alpha. Results. According to the IPAQ report, 54.8% of the participants meet the global recommendations for health, whereas, with accelerometry, the result was 52.4% (p > 0.05). On average, the participants spend more than 850 minutes a day in sedentary activities. No differences were found between the self-report and the objective accelerometry measurement of PA and sedentary behaviors in the participants of this sample. In more than half of the participants, physical fitness is considered as of a low level for all the tests considered. The participants who are housewives presented more PA in their leisure time than those who work (p < .05). Excess weight exerted an effect on overall physical activity and on balance with the eyes open (p < .05). Conclusions. Perimenopausal women usually present excess weight, sedentary behaviors, and low level of physical fitness. In this sample, no differences were found between the self-report of PA and sedentary behaviors in relation to the accelerometry measurement. Promoting active lifestyles and physical assessment in the life stage is advisable to maintain physical functionality prior to old age.
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Conference papers on the topic "Single-pa"

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Santos, Favero Guilherme, Bernardo Rego Barros de Almeida Leite, and Andre Augusto Mariano. "A Novel Single Propagation Path Multimode PA." In 2020 33rd Symposium on Integrated Circuits and Systems Design (SBCCI). IEEE, 2020. http://dx.doi.org/10.1109/sbcci50935.2020.9189920.

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Enrico De Falco, Paolo, Konstantinos Mimis, Souheil Ben Smida, Kevin Morris, Gavin Watkins, Atsushi Yamaoka, and Keiichi Yamaguchi. "Single-Ended Branch PA Characterisation for Outphasing Amplifiers." In 2018 13th European Microwave Integrated Circuits Conference (EuMIC). IEEE, 2018. http://dx.doi.org/10.23919/eumic.2018.8539963.

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Ducloué, Bertrand, Tuomas Lappi, and Yan Zhu. "Single inclusive hadron production in pA collisions at NLO." In XXIV International Workshop on Deep-Inelastic Scattering and Related Subjects. Trieste, Italy: Sissa Medialab, 2016. http://dx.doi.org/10.22323/1.265.0195.

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Liu, Ling, Wenhua Chen, Liyong Ma, and He Sun. "Single-PA-feedback digital predistortion for beamforming MIMO transmitter." In 2016 IEEE International Conference on Microwave and Millimeter Wave Technology (ICMMT). IEEE, 2016. http://dx.doi.org/10.1109/icmmt.2016.7762371.

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Nguyen, G., L. Bara, M. Samama, J. Conard, P. Van Dreden, P. Desnoyers, and A. V. Bendetowicz. "COMPARISON OF SINGLE-CHAIN AND TWO-CHAIN RECOMBINANT TISSUE-PLAS-MINOGEN ACTIVATOR (t-PA) IN VITRO. TURNOVER OF SINGLE-CHAIN t-PA IN ANIMALS AND MAN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644409.

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Two preparations of recombinant t-PA obtained from mammalian cells (Boehringer Ingelheim) containing mainly single-chain forms t-PA (sct-PA > 95%) or two-chain forms t-PA (tct-PA > 70%) were compared in vitro for their thrombolytic and fibrinogeno-lytic properties.Thrombolytic activities studied on human hanging clots were similar for both preparations, at plasma concentrations ranging from 62.5 to 1,000 IU/ml. Fibrinogenolysis appeared for both preparations at concentrations higher than 500 IU/ml, after a 90 min incubation at 37°C. For higher concentrations, fibrinogenolysis was dose-dependent, and- there was a trend with sct-PA to provoke less fibrinogenolysis.The turnover of sct-PA was studied in rabbits and cats. After an intravenous bolus injection of 0.2 mg/kg, t-PA activity and antigen showed a double decay disappearance curve. Initial and secondary phases had similar t.1/2 for the activity and the antigen, as well as in both species, which were respectively estimated about 2 min and 20 min.Although the biological and immunological clearance rates were not significantly different, sct-PA antigen values were much higher than the activity.Sct-PA clearance rate was also measured in patients with acute myocardial infarction, treated with intravenous infusion of sct-PA, 100 mg over 3 hours, of which 60 mg during the first hour (n=4). t-PA antigen was regularly measured within 20 min after the end of the first hour infusion.A biphasic disappearance curve was observed, the first phase was extremely rapid with a t.1/2 of 3.2 ± 1.2 min, and the secondary phase had a t.1/2 of 10.4 ± 2.6 min.
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Bennati, M., F. Thei, M. Rossi, M. Crescentini, G. D'Avino, A. Baschirotto, and M. Tartagni. "20.5 A Sub-pA ΔΣ Current Amplifier for Single-Molecule Nanosensors." In 2009 IEEE International Solid-State Circuits Conference (ISSCC 2009). IEEE, 2009. http://dx.doi.org/10.1109/isscc.2009.4977451.

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Dooi jewaard, G., D. J. Binnema, and C. Kluft. "CONTACT ACTIVATION AND SINGLE-CHAIN UROKINASE-TYPE PLASMINOGEN ACTIVATOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642958.

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For many years it is known that activation of the factor XII (FXII) -prekallikrein (PKK)- kininogen system of coagulation (contact activation) also may be involved in activation of fibrinolysis. Despite the numerous efforts over the past two decades to clarify this process, our current insights in this matter are far from complete. Also the physiological meaning of this possible interlinkage of coagulation and fibrinolysis is still uncertain; clearcut clinical manifestations in patients deficient in FXII or PKK are not found.No doubt, activation of fibrinolysis is a much more complicated process than it originally was thought to be, and it is only recently that the importance of urokinase for fibrinolysis in the circulation became clear. Two pathways of plasminogen (Pig) activation may be distinguished: 1. the extrinsic system, catalysed by t-PA, which upon stimulus is increasingly released from the endothelial cells of the vessel wall and 2. the intrinsic system, catalysed via Pig proactivators which circulate in the blood at a fairly constant level of concentration. The discovery that the virgin 55 kD urokinase molecule in fact is a single-chain proenzym (now denoted by scu-PA, single-chain urokinase-type PA), the notion that 55 kD scu-PA occurs in the blood and that its concentration even among individuals is fairly constant (2.1+/-0.4 ng/ml, n=52), and the observation that the efficacy of scu-PA is fibrin selective, all are recent findings pointing to the involvement of scu-PA in the intrinsic system.Still the relation between contact activation and the activation of scu-PA is obscure. Active KK, for instance, is an effective activator of 55 kD scu-PA, but proteolytic cleavage of scu-PA resulting in an active molecule, is readily achieved in plasma’s deficient in FXII or PKK. In addition, a portion of Pig activator activity which is dependent for its activation on FXII and PKK, is fully recovered in plasma’s artificially depleted in 55 kD scu-PA. Yet, both portions are activated by negatively charged surfaces or dextransulphate (DXS) as a substitute! These observations have led to the concept of two co-ordinative pathways of Pig activation for the intrinsic system: one containing scu-PA, the other containing FXII, PKK and a postulated Pig proactivator (note that the Pig activator activities of FXIIa and KK per se do not account for the latter portion of activity). Until recently in both pathways was a missing link: in the former it was the step between the negatively charged surface and scu-PA, in the latter it was the postulated Pig proactivator between active KK and Pig. This year, however, it became clear that in plasma artificially depleted in u-PA, still a substantial amount of protein immunochemically related to u-PA, can be detected (at least 35 ng/ml), but only after SDS PAGE. Part of this protein is a single-chain 110 kD molecule which in plasma can be converted to a cleaved molecule with Pig activator activity provided the plasma contains FXII and PKK. Although the relation with the 55 kD scu-PA remained unclear, the discovery of this 110 kD PA with latent urokinase antigen, undoubtedly, explains the missing link between KK and Pig. The other missing link still remains unexplained. It could be an in vitro artefact by DXS causing scu-PA catalysed activation of Pig as fibrin clots do. Since subsequently generated plasmin is capable of activation of both scu-PA and FXII, the two intrinsic pathways are thus interlinked via feed-back activation and consequently may be co-operative in function.
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Shang, Yanling, Ting Feng, Xichen Wang, Anton Khomenko, James Chen, and X. Steve Yao. "Distributed Measurement of Bending-Induced Birefringence in Single-Mode Fibers with PA-OFDR." In CLEO: Applications and Technology. Washington, D.C.: OSA, 2018. http://dx.doi.org/10.1364/cleo_at.2018.jth2a.117.

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Ali, Abdul, Jongwon Yun, Herman Jalli Ng, Dietmar Kissinger, Franco Giannini, and Paolo Colantonio. "90 GHz Bandwidth Single-Ended PA for D-Band Applications in BiCMOS Technology." In 2020 4th Australian Microwave Symposium (AMS). IEEE, 2020. http://dx.doi.org/10.1109/ams48904.2020.9059473.

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Cohen, Emanuel, Shmuel Ravid, and Dan Ritter. "Design consideration of a 5 stage bidirectional single ended LNA PA in 60GHz." In 2011 IEEE International Conference on Microwaves, Communications, Antennas and Electronic Systems (COMCAS). IEEE, 2011. http://dx.doi.org/10.1109/comcas.2011.6105923.

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Reports on the topic "Single-pa"

1

Perk, Shimon, Maricarmen Garcia, Alexander Panshin, Caroline Banet-Noach, Irina Gissin, Mark W. Jackwood, and David Stallknecht. Avian Influenza Virus H9N2: Characterization and Control Strategies. United States Department of Agriculture, June 2007. http://dx.doi.org/10.32747/2007.7709882.bard.

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Control of Avian Influenza (AI) infection is a highly topical subject of major economicimportance for the worldwide poultry industry at the national level and for international trade.H9N2 viruses are endemic in poultry throughout Asia and the Middle East, causing major losses inproduction. Moreover, these viruses pose wider threats since they have been isolated from bothswine and humans. At the same time, study of the AI viruses affords an opportunity to explore anumber of problems of intriguing scientific interest. The overall goal of this project was to developa sound control strategy for avian influenza subtype H9N2 viruses (AI H9N2) in commercialpoultry in Israel. The one-year feasibility study focused on two main goals, namely: to study themolecular characteristics of AI H9N2 circulating during the last seven years in Israel and todevelop tools enabling differentiation between the immune response to vaccination and infectionwith H9N2.Genetic and phylogenetic characterization of 29 selected AI H9N2 isolates (2000-2006)was performed by complete sequencing of hemagglutinin (HA), neuraminidase (NA), and all sixinternal genes [nucleoprotein (NP), polymerase basic 1 (PB1), polymerase basic 2 (PB2),polymerase acid (PA), matrix (M), and nonstructural (NS) genes]; comparative phylogenetic andgenetic analyses of these sequences; and comparative genetic analyses of deduced amino acidsequences of the HA, NA, NS1, and NS2 proteins. The major conclusions of the molecularanalyses were: (1) Israeli isolates, together with other H9N2 viruses isolated in Middle Eastcountries, comprise a single regional sublineage related to the G1-lineage. In addition, Israeliisolates subdivided into three different subgroups. Genetic analysis of these viruses suggests thatthey underwent divergent evolution paths.
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