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Sushma, Vasamsetti Ramya Sri, K. Nikhil, K. Ashish Reddy, and L. Sunitha. "Diagnosis of Cardiovascular Disease using Deep Learning." International Journal for Research in Applied Science and Engineering Technology 11, no. 4 (April 30, 2023): 371–78. http://dx.doi.org/10.22214/ijraset.2023.49209.
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Abstract: Cardiovascular disease is one of the most horrendous illnesses, particularly the silent heart attack that strikes a person so abruptly that there is no time for treatment. It's difficult to diagnose a disease of this nature. One of the scariest diseases that c an kill a person at any time without warning is heart disease, and most doctors are unable to predict silent heart attacks. The lac k of specialists and an increase in cases of wrong diagnoses have fueled the demand for the creation of an efficient cardiovascul ar disease prediction system. This resulted in the exploration and development of original machine learning and medical data mi ning methodologies. The principal goal of this research is to identify the most crucial qualities for silent heart attack identificatio n by using classification algorithms to extract significant patterns and features from medical data. Although it is not innovative t o build such a system, the current ones have flaws and are not designed to detect the likelihood of silent heart attacks. Another is sue with the present heart attack prediction method is the use of characteristics. Choosing the typical features for the heart attac k prediction algorithm frequently yields unreliable results. To increase prediction accuracy, the suggested method aims to extract suitable attributes from the datasets. We developed a framework in this exploration that can understand the principles of predicti ng the risk profile of patients with the clinical data parameters. This research suggests an effective neural network with convolut ional layers to classify clinical data that is noticeably class-imbalanced. In order to forecast the development of Coronary Heart Disease, data from the National Health and Nutritional Examination Survey (NHANES) is collected (CHD). This research aime d to design a robust deep-learning algorithm to predict heart disease. Heart disease prediction is performed using SMOTE and MLP Classifier algorithms and Deep Neural Network Algorithms. The effectiveness of the model that accurately predicts the pre sence or absence of heart disease was examined using DNN and ANN. In this research article, we'll look at a machine-learnin g model that can clearly assess cardiac issues and be utilized by analysts and medical professionals
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Sharma, Bhuvan, and Spinder Kaur. "Analysis and Solutions of Silent Heart Attack Using Python." International Journal of Computer Sciences and Engineering 10, no. 1 (January 31, 2022): 37–40. http://dx.doi.org/10.26438/ijcse/v10i1.3740.
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Anastasilakis, Dimitrios A., Polyzois Makras, Stergios A. Polyzos, and Athanasios D. Anastasilakis. "Asymptomatic and normocalcemic hyperparathyroidism, the silent attack: a combo-endocrinology overview." Hormones 18, no. 1 (September 25, 2018): 65–70. http://dx.doi.org/10.1007/s42000-018-0069-6.
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Teitelbaum, Michael, Rafail A. Kotronias, Luciano A. Sposato, and Rodrigo Bagur. "Cerebral Embolic Protection in TAVI: Friend or Foe." Interventional Cardiology Review 14, no. 1 (February 25, 2019): 22–25. http://dx.doi.org/10.15420/icr.2018.32.2.
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Cerebrovascular accidents including stroke or transient ischaemic attack are one of the most feared complications after transcatheter aortic valve implantation. Transcatheter aortic valve implantation procedures have been consistently associated with silent ischaemic cerebral embolism as assessed by diffusion-weighted MRI. To reduce the risk of cerebrovascular accidents and silent emboli, cerebral embolic protection devices were developed with the aim of preventing procedural debris reaching the cerebral vasculature. The authors summarise the available data regarding cerebral embolic protection devices and its clinical significance.
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Mykland, Martin Syvertsen, Martin Uglem, Lars Jacob Stovner, Eiliv Brenner, Mari Storli Snoen, Gøril Bruvik Gravdahl, Trond Sand, and Petter Moe Omland. "Insufficient sleep may alter cortical excitability near the migraine attack: A blinded TMS crossover study." Cephalalgia 43, no. 3 (February 14, 2023): 033310242211483. http://dx.doi.org/10.1177/03331024221148391.
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Background Migraine is a brain disorder with a multifaceted and unexplained association to sleep. Brain excitability likely changes periodically throughout the migraine cycle. In this study we examine the effect of insufficient sleep on neuronal excitability during the course of the migraine cycle. Methods We examined 54 migraine patients after two nights of eight-hour habitual sleep and two nights of four-hour restricted sleep in a randomised, blinded crossover study. We performed transcranial magnetic stimulation and measured cortical silent period, short- and long-interval intracortical inhibition, intracortical facilitation and short-latency afferent inhibition. We analysed how responses changed before and after attacks with linear mixed models. Results Short- interval intracortical inhibition was more reduced after sleep restriction compared to habitual sleep the shorter the time that had elapsed since the attack ( p = 0.041), and specifically in the postictal phase ( p = 0.013). Long-interval intracortical inhibition was more increased after sleep restriction with time closer before the attack ( p = 0.006), and specifically in the preictal phase ( p = 0.034). Short-latency afferent inhibition was more decreased after sleep restriction with time closer to the start of the attack ( p = 0.026). Conclusion Insufficient sleep in the period leading up to a migraine attack may cause dysfunction in cortical GABAergic inhibition. The results also suggest that migraine patients may have increased need for sufficient sleep during a migraine attack to maintain normal neurological function after the attack.
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Li, Ying, Nan Liu, Yonghua Huang, Wei Wei, Fei Chen, and Weiwei Zhang. "Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack." Medical Science Monitor 22 (February 11, 2016): 447–53. http://dx.doi.org/10.12659/msm.895759.
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Yang, Tiancheng, Ankit Mittal, Yunsi Fei, and Aatmesh Shrivastava. "Large Delay Analog Trojans: A Silent Fabrication-Time Attack Exploiting Analog Modalities." IEEE Transactions on Very Large Scale Integration (VLSI) Systems 29, no. 1 (January 2021): 124–35. http://dx.doi.org/10.1109/tvlsi.2020.3034878.
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Demirel, Esra Aciman, Ufuk Emre, Aysun Ünal, Banu Özen, H. Tuğrul Atasoy, and Fürüzan Öztürk. "Evaluation of silent cerebral lesions in patients with first ischemic stroke attack." Neurology, Psychiatry and Brain Research 18, no. 1 (January 2012): 22–26. http://dx.doi.org/10.1016/j.npbr.2011.12.001.
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Howard, George, Gregory W. Evans, and James F. Toole. "Silent cerebral infarctions in transient ischemic attack populations: Implications of advancing technology." Journal of Stroke and Cerebrovascular Diseases 4 (January 1994): S47—S50. http://dx.doi.org/10.1016/s1052-3057(10)80257-5.
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Jati, Wasisto. "From bombing to social media: The role of returning foreign fighters in nurturing terrorism in Asian countries." Simulacra 4, no. 2 (November 18, 2021): 201–13. http://dx.doi.org/10.21107/sml.v4i2.11688.
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This article aims for revisiting the terrorism studies from different perspective. The terror attacks itself cannot be hundred percent zero but it just fluctuated trend. More specifically, terrorism always adaptive in following trends. While terror attacks still to target innocent civilians, the perpetrators could be closest relatives and neighbors. The way terror attack to reach out that group of people basically shows the silent role of returning foreign fighters (RFF)/returnees nurturing dan breeding terror ideologies. By using critical literature review especially historical narrative analysis, this study wants to examine the current terror trend that utilizes social media. It can spread terror narration and also affecting people to join. The way to analyze data is making clear connection from each literature. The findings of this study are: the RFF is adept at social media in nurturing terror ideologies and then making their home country and new terrorist cells to be breeding grounds.
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Keshavarz, Mohammad Hossein. "Impoliteness in Power-imbalance and Power-neutral Relational Contexts: Evidence from a Persian TV Drama." Journal of Pragmatics Research 4, no. 1 (February 7, 2022): 41–59. http://dx.doi.org/10.18326/jopr.v4i1.41-59.
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This study investigated impoliteness in relational contexts. Interlocutors analyzed the data from a Persian TV drama from two perspectives: intentionality and perception of impoliteness. Two relational contexts were identified: power-imbalance and power-neutral, each comprising two types of impoliteness: reciprocal and non-reciprocal. Reciprocal impoliteness occurred in hostile and conflictual situations where impoliteness was both intended by the speaker and perceived by the recipient as a direct face-attack. In non-reciprocal impoliteness, however, when power imbalance was due to family hierarchy, the recipient of impoliteness remained silent; in other situations, the intentional face-attack was tolerated, unless the recipient’s social identity face was directly attacked. In power-neutral situations, impoliteness was not reciprocated when intimacy existed between the interactants. It was neither intended nor perceived as face-threatening; however, direct face-attack was reciprocal in hostile situations. The findings of the present study point to the significant role of the relational context in the interpretation of impoliteness.
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Kazantsev, A. N., R. A. Vinogradov, M. A. Chernyavsky, V. N. Kravchuk, V. V. Matusevich, K. P. Chernykh, A. R. Shabaev, et al. "Multicenter study: carotid endarterectomy in the first hours after ischemic stroke." Russian Journal of Cardiology 26, no. 6 (July 16, 2021): 4316. http://dx.doi.org/10.15829/1560-4071-2021-4316.
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Aim. To analyze inhospital outcomes of carotid endarterectomy (CE) in the acute period (within 3 days from the onset) of ischemic stroke.Material and methods. This retrospective multicenter study for the period from January 2008 to August 2020 included 357 patients who underwent CE in the acute period of stroke. An interdisciplinary commission defined the revascularization timing. There were following inclusion criteria: 1. Mild neurological disorders: NIHSS stroke of 3-8; modified Rankin Scale score <2; Bartel index >61; 2. Indications for CE according to the current national guidelines; 3. Brain ischemic focus <2,5 cm in diameter. There were following exclusion criteria: 1. Presence of contraindications to CE. The endpoints were such unfavorable cardiovascular events as death, myocardial infarction (MI), stroke/transient ischemic attack (TIA), silent stroke, silent hemorrhagic transformations, Bleeding Academic Research Consortium (BARC) type >3b bleeding, internal carotid artery thrombosis, composite endpoint (death + all strokes/TIA + MI). Silent strokes were those strokes, established according to control multi-slice computed tomography angiography, without symptoms.Results. During the in-hospital follow-up period, 8 deaths (2,24%), 5 MIs (1,4%), 6 strokes/TIAs (1,7%), 15 silent ischemic strokes (4,2%), 13 hemorrhagic transformations (3,6%), 26 silent hemorrhagic transformations (7,3%), and 6 BARC type >3b bleeding (1,7%) were recorded. Thus, the combined endpoint was 20,4% (n=73).Conclusion. Due to the high incidence of cardiovascular events, CE is not a safe operation for patients in the acute period of ischemic stroke. The stroke + mortality rate exceeding 3% demonstrates the ineffectiveness of this method of treatment.
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Geyer, Thomas F., Vanessa T. Claus, Philipp M. Hall, and Ennes Sarradj. "Silent owl flight: The effect of the leading edge comb." International Journal of Aeroacoustics 16, no. 3 (April 2017): 115–34. http://dx.doi.org/10.1177/1475472x17706131.
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The feathers of owls possess three adaptations that are held responsible for their quiet flight. These are a comb-like structure at the leading edge of the wing, fringes at the trailing edge, and a soft and porous upper surface of the wing. To investigate the effect of the first adaptation, the leading edge comb, on the aerodynamic performance and the noise generation during gliding flight, wind tunnel measurements were performed on prepared wings of a Barn owl ( Tyto alba) with and without the comb. In agreement with existing studies it was found that the leading edge comb causes a small increase in lift. Additionally, at high angles of attack the results from the acoustic measurements indicate that the presence of the comb leads to a reduction in gliding flight noise. Although this reduction is relatively small, it further helps the owl to approach its prey during the final stages of the landing phase.
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Salem, Ahmed, Xuening Liao, Yulong Shen, and Xiaohong Jiang. "Provoking the Adversary by Detecting Eavesdropping and Jamming Attacks: A Game-Theoretical Framework." Wireless Communications and Mobile Computing 2018 (August 28, 2018): 1–14. http://dx.doi.org/10.1155/2018/1029175.
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This paper investigates the secrecy and reliability of a communication where the user is assisting an Intrusion Detection System (IDS) in detecting the adversary’s attack. The adversary is assumed to be sophisticated such that it can conduct eavesdropping and jamming attacks. The IDS is equipped with the capability of detecting both of those attacks. Two scenarios were considered; the first scenario is that the user is trying to detect the adversary by assisting the IDS, and the second scenario is that the user is equipped with a silent time slot in its communication protocol besides assisting the IDS, in order to provoke the adversary into jamming the channel, thus detecting it with a higher probability. Interestingly, adding the capability of detecting eavesdropping attacks pushed the adversary into conducting jamming attacks much more, thus aiding in detecting the adversary earlier. All of that was modeled by means of stochastic game theory, in order to analyze and study the behavior and the interactions between the user and the adversary. Results show a major improvement in the first scenario by 188% and an improvement by 294% in the second scenario in the game value when the probability of detecting eavesdropping attacks was 0.3, which represents the payoff that the user gains in terms of secrecy and reliability.
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Li, Rui-Yan, Zhi-Gang Cao, Ji-Rong Zhang, Ying Li, and Rui-Tao Wang. "Decreased Serum Bilirubin Is Associated With Silent Cerebral Infarction." Arteriosclerosis, Thrombosis, and Vascular Biology 34, no. 4 (April 2014): 946–51. http://dx.doi.org/10.1161/atvbaha.113.303003.
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Objective— The presence of silent cerebral infarction (SCI) increases the risk of transient ischemia attack, symptomatic stroke, cardiovascular disease, and dementia. Total bilirubin (TB) levels were demonstrated to be decreased in carotid intima–media thickness, cardiovascular disease, stroke, and peripheral arterial disease. However, little information is available concerning the correlation between TB and SCI. Approach and Results— A cross-sectional study was conducted to evaluate the association between TB and SCI in 2865 subjects (1831 men and 1034 women) undergoing medical checkup. The participants with SCI had lower TB levels than those without SCI. The subjects with a low TB had a higher prevalence of SCI. Moreover, partial correlation showed that TB levels were tightly correlated with brachial-ankle pulse wave velocity after adjusting for confounding covariates ( r =−0.149; P <0.001). Multivariate logistic regression analysis revealed that higher TB was associated with a lower risk of SCI (odds ratio, 0.925; 95% confidence interval, 0.897–0.954; P <0.001). Conclusions— TB is a novel biochemical indicator for SCI regardless of classical cardiovascular risk factors. Early measurement of TB may be useful to assess the risk of SCI.
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Sirmatel, Fatma, Munife Neyal Muftuoglu, Nursan Tahtaci, Abdurrahman Neyal, Binnur Bulbul, and Ocal Sirmatel. "Chlamydia Pneumoniae Seropositivity in Patients with Cerebral Ischemic Attack with or without Silent Brain Infarcts." Upsala Journal of Medical Sciences 108, no. 3 (January 2003): 205–12. http://dx.doi.org/10.3109/2000-1967-114.
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Fernandez, Vanessa, Yannick Béjot, Marianne Zeller, Joëlle Hamblin, Benoit Daubail, Agnes Jacquin, Maud Maza, Claude Touzery, Yves Cottin, and Maurice Giroud. "Silent Atrial Fibrillation after Ischemic Stroke or Transient Ischemic Attack: Interest of Continuous ECG Monitoring." European Neurology 71, no. 5-6 (2014): 313–18. http://dx.doi.org/10.1159/000357561.
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Ahmad, E., A. Singh, R. R. Chaudhary, and M. S. Sarda. "Assessment of cardiac complication in diabetic patient of rural India." International Journal of Research in Medical Sciences 8, no. 8 (July 24, 2020): 2958. http://dx.doi.org/10.18203/2320-6012.ijrms20203446.
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Background: Diabetes mellitus (DM) is a common endocrine disorder affecting approximately 382 million people worldwide. Diabetes mellitus (DM) is group of metabolic disorder in which glucose is underutilized, thus producing hyperglycemia resulting from a defect in insulin secretion, action, or both. Cardiovascular disease is the most common cause of death and disability among people with diabetes. The cardiovascular disease that accompany diabetes include angina, myocardial infarction (heart attack), Stroke, peripheral artery disease and congestive heart failure. In people with diabetes, high blood pressure, high cholesterol, high blood glucose and other risk factors contribute to the increased risk of cardiovascular complications.Method: This study was conducted to determine the cardiac complication in diabetic patient of rural India. It was Cross sectional retrospective study, done in between period of January 2018 to December 2019.Result: In the present study authors found that 47.7% patients have Coronary artery disease (CAD), Silent 21.6% have myocardial ischemia (SMI), 36% Diastolic dysfunction (DF), 28.8% have Systolic dysfunction (SDF).Conclusion: In this study authors found that wide spectrum of cardiac complications in diabetic patients ranging silent myocardial ischemia to heart failure. CAD was the most common complication including silent myocardial ischemia (SMI) which is the one of the major concern of rural diabetic population which need proper screening by exercise treadmill test.
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Güler, Muhlike, Fuat Laloğlu, and Naci Ceviz. "Changes in valvular regurgitation in mid-term follow-up of children with first attack acute rheumatic fever: first evaluation after the updated Jones criteria." Cardiology in the Young 30, no. 3 (January 10, 2020): 369–71. http://dx.doi.org/10.1017/s1047951119003317.
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AbstractAim:In present study, we aimed to evaluate the changes in valvular regurgitations in mid-term follow-up of children with first attack acute rheumatic fever diagnosed after updated Jones criteria.Materials and methods:The medical records of the children diagnosed with acute rheumatic fever between June 2015 and November 2018 were evaluated retrospectively. When compared to the findings during diagnosis, the changes in the degree of valvular regurgitation in the last visit were coded as same, regressed, or disappeared.Results:A total of 50 children were diagnosed with the first attack of acute rheumatic fever between the noted dates. Nine patients (18%) could be diagnosed depending on the new criteria. Eight patients did not have carditis, and 35 patients (49 valves) could be followed for a median follow-up period of 11.7 ± 3.3 months. In our study, the valvar lesions continued in 82% of patients with clinical carditis at the end of the first year and the degree of valvular regurgitation decreased in 39% of them. Despite this, in a significantly higher (p = 0.031) ratio of patients with silent carditis (41%), valvar lesions disappeared in the same follow-up period. In 18.4% of the involved valves, regurgitation regressed to physiological level.Conclusion:Updated Jones criteria make it possible to diagnose a significant number of patients, and the ratio of complete recovery among patients with silent carditis is significantly higher. Also, it can be speculated that the normal children in whom a physiological mitral regurgitation is detected should be followed in terms of rheumatic heart disease.
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Agarwal, Megha, M. L. Yadav, R. M. Jaiswal, and Pradeep Kumar Bansal. "Stroke in sickle cell disease: case report." International Journal of Research in Medical Sciences 8, no. 5 (April 27, 2020): 1928. http://dx.doi.org/10.18203/2320-6012.ijrms20201954.
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Sickle cell disease is an inherited blood disorder that affects red blood cells. It is characterized by polymerization of haemoglobin, erythrocyte stiffening, and subsequent vaso-occlusions. These can lead to microcirculation obstructions, tissue ischemia, infarction and acute stroke. Transient ischemic attack, Ischaemic stroke, haemorrhagic stroke, silent cerebral infarction, headache, Moyamoya disease, neuropathic pain, and neurocognitive impairment are neurological complications of sickle cell disease. Here we report a case of ischemic stroke in a patient of sickle cell disease. For early diagnosis and proper management of sickle cell disease neurological complications require specialised haematological and neurological expertise. The newly used medications under ongoing research will be the hope to overcome this devastating disease and its complications.
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Giroud, M., and J. Reis. "Stroke and air pollution. a worldwide public health problem." Health Risk Analysis, no. 3 (September 2020): 19–22. http://dx.doi.org/10.21668/health.risk/2020.3.02.
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After myocardial infarction, stroke is now associated with air pollution. From local data and literature, we report the strength of the association between air pollution and stroke. We try to understand the biological mechanisms between exposure to air pollutants and stroke risk. The association between air pollution and stroke is strong, confirmed and real. Air pollution and small particulate matter are the most toxic. Patients with classical neuro-vascular risk factors or a history of stroke or transient ischemic attack are at risk of stroke induced by air pollution. Air pollution is a serious modifiable risk factor for stroke and a silent killer inducing stroke. This new neuro-vascular risk factor is useful for public health policies.
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Giroud, M., and J. Reis. "Stroke and air pollution. a worldwide public health problem." Health Risk Analysis, no. 3 (September 2020): 19–22. http://dx.doi.org/10.21668/health.risk/2020.3.02.eng.
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After myocardial infarction, stroke is now associated with air pollution. From local data and literature, we report the strength of the association between air pollution and stroke. We try to understand the biological mechanisms between exposure to air pollutants and stroke risk. The association between air pollution and stroke is strong, confirmed and real. Air pollution and small particulate matter are the most toxic. Patients with classical neuro-vascular risk factors or a history of stroke or transient ischemic attack are at risk of stroke induced by air pollution. Air pollution is a serious modifiable risk factor for stroke and a silent killer inducing stroke. This new neuro-vascular risk factor is useful for public health policies.
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Herderscheê, D., A. Hijdra, A. Algra, P. J. Koudstaal, L. J. Kappelle, and J. van Gijn. "Silent stroke in patients with transient ischemic attack or minor ischemic stroke. The Dutch TIA Trial Study Group." Stroke 23, no. 9 (September 1992): 1220–24. http://dx.doi.org/10.1161/01.str.23.9.1220.
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Garnaev, Andrey, Wade Trappe, and Athina Petropulu. "A Dilemma in the Communication of a UAV with its Controller." International Game Theory Review 22, no. 02 (April 18, 2020): 2040003. http://dx.doi.org/10.1142/s0219198920400034.
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In this paper, we investigate a dilemma of employing silent mode and communication mode by an unmanned aerial vehicle (UAV) in communication with its controller. In many applications, a UAV communicates with a controller to receive instructions or accurate positioning, but such active communication poses a threat that the UAV can be hijacked through spoofing. On the other hand, during a silent mode (when the UAV does not communicate with the controller), the UAV is safe from spoofing, but is not receiving updates or other important data, and can degrade the overall UAV mission. To gain insight into the UAV risk versus benefit tradeoff, a simple game-theoretic model is presented. Additionally, this paper investigates how incomplete information about the capability of the controller to quickly learn the adversary’s attack and adjust its strategy accordingly can impact the equilibrium strategies. In contrast to regular-type capability, when both the rivals maximize their payoffs simultaneously, the capability of the controller to quickly learn is modeled by having the controller apply the best-response strategy. We model this problem using a Bayesian game, where the adversary knows only a priori probabilities about what capability the controller has. Dependence of the equilibrium strategies on these a priori probabilities is illustrated.
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Vyas, N., H. Alkhawam, R. Sogomonian, RA Ching Companioni, and A. Walfish. "ID: 37: SILENT BUT DEADLY CYTOMEGALOVIRUS TRIGGERING AUTOIMMUNE HEPATITIS." Journal of Investigative Medicine 64, no. 4 (March 22, 2016): 942.2–943. http://dx.doi.org/10.1136/jim-2016-000120.62.
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IntroductionTo consider that viruses, more specifically cytomegalovirus (CMV), can trigger autoimmune hepatitis.Case Report54 year-old female presents with new onset jaundice, which was associated with abdominal distension, lower extremity edema and 10 pound weight gain. She has no history of intravenous drug use, blood transfusions, any new sexual partners in over 8 years or a family history of liver disease. The physical examination was remarkable for spider angiomata, icteric sclera, ascites, and edema.The results of the biochemical analysis of the blood were the following: Liver enzymes were all elevated ALP 162 U/L, GGT 65 U/L, AST 154 U/L, ALT 72 U/L. Furthermore, her autoimmune workup was significant for an elevated ANA titer of 1:640, anti-smooth muscle ab titer 1:40 and a significant increase in immunoglobulins specifically IgG which was 4100 mg/dL. Interestingly, CMV Ab IgM was positive at 36.6 u/mL as well as CMV Ab IgG, which was positive at >10.00 u/mL. The rest of the work up was unremarkable in regards to hepatitis A, B, C, HIV, HSV, Epstein Barr virus (EBV), alpha1 antitrypsin, ceruloplasmin, iron level, ferritin and antimitochondrial ab. A liver biopsy was performed which showed heavy infiltration with lymphoplasmacytic inflammatory cells, interface hepatitis, bridging necrosis, and fibrosis. These pathologic and laboratory findings led us to a definitive diagnosis of autoimmune hepatitis (AIH) Type 1. In the setting of positive CMV IgG and IgM ab titers, we suggest that the trigger for AIH in this case was a preceding CMV infection. Her evolution was satisfactory under corticosteroid and azathioprine therapy.DiscussionAutoimmune hepatitis is a chronic hepatocellular inflammation and necrosis of unknown cause. The most supported pathogenesis of AIH postulates that a combination of environmental triggers, failure of immune system tolerance and a genetic predisposition that may induce a T cell–mediated immune attack against the liver. Case studies in the literature report AIH being triggered by virus and drugs. There is evidence of cross-reactivity between anti-LKM1 and antibodies against homologous regions of cytomegalovirus (exon CMV130-135). This case could explain an association between cytomegalovirus infection and autoimmune hepatitis.As clinicians, it is difficult to diagnose autoimmune hepatitis because its presentation can be acute, severe, asymptomatic or chronic. Diagnosis requires multiple findings and exclusions of similar diseases. When excluding, make sure viral etiologies are part of the differential, which in this case is CMV. If indeed a trigger is required to set off a sequence of events leading to autoimmune hepatitis in these predisposed individuals, viruses are among the most likely candidates.Abstract ID: 37 Figure 1
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Elmelund-Præstekær, Christian, Michael Baggesen Klitgaard, and Gijs Schumacher. "What wins public support? Communicating or obfuscating welfare state retrenchment." European Political Science Review 7, no. 3 (November 24, 2014): 427–50. http://dx.doi.org/10.1017/s1755773914000253.
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Conventional wisdom holds that in order to evade electoral punishment governments obfuscate welfare state retrenchment. However, governments do not uniformly lose votes in elections after they cut back on welfare benefits or services. Recent evidence indicates that some of these unpopular reforms are in fact vote-winners for the government. Our study of eight Danish labor marked related reforms uses insights from experimental framing studies to evaluate the impact of welfare state retrenchment on government popularity. We hypothesize that communicating retrenchment is a better strategy than obfuscating retrenchment measures. In addition, we hypothesize that the opposition’s choice between arguing against the retrenchment measure, or staying silent on the issue, affects the government’s popularity. Thus, the study presents a novel theoretical model of the popularity effects of welfare state retrenchment. In order to evaluate our propositions, we move beyond the standard measure in the literature and use monthly opinion polls to reduce the number of other factors that might affect government popularity. We demonstrate that governments can evade popular punishment by communication. They can even gain popularity if the opposition chooses not to attack. On the other hand, government popularity declines if the government obfuscates – and the decline is even larger if the opposition chooses to attack.
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Sari, Dewi Puspito, and Dwi Sutiningsih. "Primary Risk of Hypertension in Women with Age 45 - 54 Years." STRADA JURNAL ILMIAH KESEHATAN 8, no. 2 (November 19, 2019): 123–28. http://dx.doi.org/10.30994/sjik.v8i2.200.
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Hypertension is the silent killer, one of the main risk factors for heart attack and stroke. Based on Riskesdas data in 2018 the prevalence of hypertension blood pressure measurements in Indonesia increased by 8.3%, from 25.8% (in 2013) to 34.1% (in 2018). The prevalence of hypertension in Jambi Province based on the results of the 2013 Riskesdas was quite high at 24.6%. In Sarolangun Regency primary hypertension was second only to ARI, which was 16.3%. But the study of the characteristics of patients with primary hypertension in Sarolangun District is still limited. The purpose of this study was to determine the characteristics of patients with primary hypertension, especially the age and sex of patients in Sarolangun District in 2016. The method of this study was an observational descriptive study, with a case control study design. The sampling technique uses total sampling.
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Saleem, Tayyaba, Hafsa Maqbool, Saira Suqaina, Mavra Irfan, Raana Zafar, and Nadeem Sheikh. "A Synonymous Variant, GABRG2 rs211037 might be a Predictive Genetic Marker of Migraine: A Case Control Study from Pakistan." Albus Scientia 2022, no. 1 (June 28, 2022): 1–6. http://dx.doi.org/10.56512/as.2022.1.e220628.
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Background: Migraine is a severe neurovascular disease with some temporary symptoms like unilateral headache attacks associated with sensory and autonomic disturbances. It affects 12% of the general population worldwide. Females are more susceptible to migraine than males. The genetic and environmental factors contribute as a causative agent to its symptomatology. Gamma-aminobutyric acid (GABA) neurotransmitter plays a potential role in migraine pathophysiology that prompted us to evaluate the association between gamma-aminobutyric acid type a receptor gamma two subunit gene (GABRG2) polymorphisms and the risk of a migraine attack. Methods The present case-control study included 220 subjects (100 control; 120 patients). Blood samples were taken from all the participants and DNA was isolated. The selected SNPs (rs211037, rs121909672, and T813C) of exons 5, 7, and 8 of the GABRG2 gene were genotyped for cases and controls. Results: A silent polymorphism was found at the rs211037 polymorphic site, while no variation was found on other targeted sites either in the case or control population. Statistical analysis indicated significant differences in genotypic (p=<0.05) and allelic frequencies (p = <0.001; OR 2.039; 95% CI 1.346-3.089) and for dominant model (p = <0.001; OR 2.836; 95% CI 1.618-4.970). Conclusion: The result of our study showed that rs211037 polymorphism of the GABRG2 gene was significantly associated with migraines in the Pakistani population.
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Ost, David. "“Down with 1989!”: The Peculiar Right-Wing Backlash against 1968 in Poland." East European Politics and Societies: and Cultures 33, no. 4 (September 27, 2019): 843–60. http://dx.doi.org/10.1177/0888325419857141.
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This article is part of the special cluster titled Generation ’68 in Poland (with a Czechoslovak Comparative Perspective). Whereas much of the European right greeted the fiftieth anniversary of 1968 with a critique of its legacy, Poland’s ruling Law and Justice party was largely silent, both because 1968 did not usher in a counterculture and because the protests were directed against the communist party. And yet the Law and Justice party detests the legacy of 1968, for three reasons: 1968 was shaped by the left, ’68 activists and their values played a key role in the ensuing opposition, and because the right actually sympathizes with the communists of 1968, then dominated by nationalists. The right thus traditionally attacks the legacy of 1968 by attacking 1989 instead, when ’68’ ers played a central role and new left progressivism could finally emerge. That began changing early in 2018 when Poland’s parliament passed its Holocaust-speech law banning calumny against the “Polish Nation.” The resulting criticism brought 1968 back with a vengeance, with the right openly inhabiting the role of the national-communists, and beginning to attack Poland’s 1968 directly. Shedding new light on the diverse meanings of 1968 and the relationship of the right to national communism, the piece ends by looking at developments through Bernhard and Kubik’s theory of the politics of memory.
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Widyasari, Kristin, Mazen Alazem, and Kook-Hyung Kim. "Soybean Resistance to Soybean Mosaic Virus." Plants 9, no. 2 (February 8, 2020): 219. http://dx.doi.org/10.3390/plants9020219.
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Soybean mosaic virus (SMV) occurs in all soybean-growing areas in the world and causes huge losses in soybean yields and seed quality. During early viral infection, molecular interactions between SMV effector proteins and the soybean resistance (R) protein, if present, determine the development of resistance/disease in soybean plants. Depending on the interacting strain and cultivar, R-protein in resistant soybean perceives a specific SMV effector, which triggers either the extreme silent resistance or the typical resistance manifested by hypersensitive responses and induction of salicylic acid and reactive oxygen species. In this review, we consider the major advances that have been made in understanding the soybean–SMV arms race. We also focus on dissecting mechanisms SMV employs to establish infection and how soybean perceives and then responds to SMV attack. In addition, progress on soybean R-genes studies, as well as those addressing independent resistance genes, are also addressed.
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Fridman, Sebastian, Stephen P. Lownie, and Jennifer Mandzia. "Diagnosis and management of carotid free-floating thrombus: A systematic literature review." International Journal of Stroke 14, no. 3 (February 6, 2019): 247–56. http://dx.doi.org/10.1177/1747493019828554.
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Background There is no consensus regarding the management of carotid free-floating thrombi in patients with acute ischemic stroke and transient ischemic attack. Aims This systematic review aims to (1) describe the current imaging methods for diagnosis of carotid free-floating thrombi and its associated risk factors, (2) estimate the proportion of carotid free-floating thrombi diagnosed in stroke patients, (3) estimate the proportion of carotid free-floating thrombi patients treated medically and surgically, and (4) evaluate 30-day outcomes. Methods We searched MEDLINE, EMBASE, and manually for references reporting carotid free-floating thrombi from 1960 until June 2017. We estimated the frequency of carotid free-floating thrombi and evaluated 30-day outcomes using Cox regression. We defined the timing of surgical intervention as early (less than 72 h) and delayed (more or equal to 72 h). Summary of review We retrieved 525 carotid free-floating thrombi cases from 58 case series and 83 case reports. Carotid free-floating thrombi were present in 1.53% of stroke patients. Carotid free-floating thrombi diagnosis was made by digital subtraction angiography (38.1%), carotid duplex ultrasound (29.5%), and computed tomography angiography (29.5%). The 30-day risk of transient ischemic attack, silent brain ischemia, any stroke or death was 17.1%. In multivariate analyses, there were no differences in outcome for any anticoagulation regime or timing of revascularization procedure. Conclusions The diagnosis of carotid free-floating thrombi is more common due to the increased use of early noninvasive vascular imaging in transient ischemic attack and stroke. It poses a high short-term risk of stroke and death, but there is as yet no established treatment. The low quality of evidence in the carotid free-floating thrombi literature limits the interpretation of our results and warrants a large-scale prospective cohort study in carotid free-floating thrombi.
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Breen, Michelle Dunne, Patricia Easteal, Kate Holland, Georgina Sutherland, and Cathy Vaughan. "Exploring Australian journalism discursive practices in reporting rape: The pitiful predator and the silent victim." Discourse & Communication 11, no. 3 (March 17, 2017): 241–58. http://dx.doi.org/10.1177/1750481317697858.
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This article draws on the qualitative research component of a mixed-methods project exploring the Australian news media’s representation of violence against women. This critical discourse analysis is on print and online news reporting of the case of ‘Kings Cross Nightclub Rapist Luke Lazarus’, who in March 2015 was tried and convicted of raping a female club-goer in a laneway behind his father’s nightclub in Sydney, Australia. We explore the journalism discursive practices employed in the production of the news reports about the Lazarus trial. Our analysis shows how some lexical features, quoting strategies and structuring elements serve to minimise the victim’s experience while emphasising the adverse effects of the trial on the accused. Furthermore, we demonstrate how such practices allow for the graphic representation of the attack in a salacious manner while minimising the impact of the crime on the victim by selectively referencing her victim impact statement. We found some differences between print and online news stories about this case, some of which may be attributable to the greater space available to the telling of news stories online. We conclude that in news reporting of the Lazarus case, routine journalism discursive practices, such as the inverted pyramid news-writing structure and decisions about who and what to quote, serve simultaneously to diminish the victim’s experience while objectifying her. These results build on international findings about media reporting practices in relation to violence against women and add substantially to what we know about these practices in Australia.
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Bedrick, Jeffrey D. "Mental Illness And Brain Disease." Folia Medica 56, no. 4 (December 1, 2014): 305–8. http://dx.doi.org/10.1515/folmed-2015-0012.
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Abstract It has become common to say psychiatric illnesses are brain diseases. This reflects a conception of the mental as being biologically based, though it is also thought that thinking of psychiatric illness this way will reduce the stigma attached to psychiatric illness. If psychiatric illnesses are brain diseases, however, it is not clear why psychiatry should not collapse into neurology, and some argue for this course. Others try to maintain a distinction by saying that neurology deals with abnormalities of neural structure while psychiatry deals with specific abnormalities of neural functioning. It is not clear that neurologists would accept this division, nor that they should. I argue that if we take seriously the notion that psychiatric illnesses are mental illnesses we can draw a more defensible boundary between psychiatry and neurology. As mental illnesses, psychiatric illnesses must have symptoms that affect our mental capacities and that the sufferer is capable of being aware of, even if they are not always self-consciously aware of them. Neurological illnesses, such as stroke or multiple sclerosis, may be diagnosed even if they are silent, just as the person may not be aware of having high blood pressure or may suffer a silent myocardial infarction. It does not make sense to speak of panic disorder if the person has never had a panic attack, however, or of bipolar disorder in the absence of mood swings. This does not mean psychiatric illnesses are not biologically based. Mental illnesses are illnesses of persons, whereas other illnesses are illnesses of biological individuals.
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Ramarianda, Ninda Putri. "FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN TEKANAN DARAH PASIEN HIPERTENSI." JURNAL MEDIA KESEHATAN 8, no. 1 (November 13, 2018): 63–70. http://dx.doi.org/10.33088/jmk.v8i1.259.
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Hypertension is often referred to as the silent killer. Hypertension is a condition of elevated bloodpressure in the arteries that lead to increased risk for stroke, aneurysm, heart failure, heart attack and kidneydamage. Some of the causes of hypertension were age, sex, carbohydrate intake, saturated fat and unsaturatedfat. The purpose of this study to determine the factors that most influence the blood pressure of hypertensivepatients. This type of research analytic survey with a cross-sectional design with independent variables (age,sex, carbohydrate intake, saturated fat and unsaturated fat) and the dependent variable (blood pressure). Totalpopulation of 476 hypertensive patients. Samples taken by accidental sampling. The Total samples is 83. Theresults showed that there is a significant relationship between age, intake of carbohydrates, saturated fat andunsaturated fat with blood pressure. There is no significant difference in blood pressure between the sexes. Themost dominant factor is the systolic blood pressure is age and diastolic blood pressure is carbohydrate intake.
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Ramarianda, Ninda Putri. "FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN TEKANAN DARAH PASIEN HIPERTENSI." JURNAL MEDIA KESEHATAN 8, no. 1 (November 13, 2018): 63–70. http://dx.doi.org/10.33088/jmk.v8i1.259.
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Hypertension is often referred to as the silent killer. Hypertension is a condition of elevated bloodpressure in the arteries that lead to increased risk for stroke, aneurysm, heart failure, heart attack and kidneydamage. Some of the causes of hypertension were age, sex, carbohydrate intake, saturated fat and unsaturatedfat. The purpose of this study to determine the factors that most influence the blood pressure of hypertensivepatients. This type of research analytic survey with a cross-sectional design with independent variables (age,sex, carbohydrate intake, saturated fat and unsaturated fat) and the dependent variable (blood pressure). Totalpopulation of 476 hypertensive patients. Samples taken by accidental sampling. The Total samples is 83. Theresults showed that there is a significant relationship between age, intake of carbohydrates, saturated fat andunsaturated fat with blood pressure. There is no significant difference in blood pressure between the sexes. Themost dominant factor is the systolic blood pressure is age and diastolic blood pressure is carbohydrate intake.
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Milicevic, Miroslav. "Acute cholecystitis." Acta chirurgica Iugoslavica 50, no. 4 (2003): 27–33. http://dx.doi.org/10.2298/aci0304027m.
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Only 20 - 30% of patients with gallstones have symptoms and the probability of a patient with silent gallstones developing biliary-related pain is 1- 2% while the risk of developing a serious complication (e.g. empyema, perforation, peritonitis etc.) is less than 0.1% per year. Imaging techniques are important in establishing the diagnosis and evaluating the patient. Laparoscopic cholecystectomy (LC) is the golden standard for the management of symptomatic gallstones and there are two surgical treatment options: early cholecystectomy (same hospital admission) and interval (delayed) cholecystectomy (6-8 weeks after resolution of acute attack). Early LC has medical and socioeconomic advantages over interval LC. LC can be undertaken for the majority of patients with AC and in some high risk groups the postoperative mortality can even be reduced. LC in AC is associated with longer operating time, a higher rate of conversion and bile damage. Early diagnosis and early operation can prevent the development of complications associated with AC.
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Guanglei, Meng, Zhao Runnan, Wang Biao, Zhou Mingzhe, Wang Yu, and Liang Xiao. "Target Tactical Intention Recognition in Multiaircraft Cooperative Air Combat." International Journal of Aerospace Engineering 2021 (November 9, 2021): 1–18. http://dx.doi.org/10.1155/2021/9558838.
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Accurately identifying the tactical intention of the target can facilitate the prediction of the opponent’s behavior and improve the efficiency of collaborative decision. We have observed that traditional methods could achieve high recognition rate on conventional tactical intent. Nevertheless, their performance would deteriorate seriously when recognizing cooperative tactical intention in multiaircraft air combat environment. The main reason resides on key features that are difficult to extract for traditional methods. To this end, this paper proposes a novel approach to recognizing tactical intention of multiaircraft cooperative air combat. Specifically, we employ support vector machine (SVM) to forecast the attack intention based on 19 low correlation features. The purpose of the employment of SVM is to avoid local optimization and reduce data dimension. Moreover, we use three models, i.e., dynamic Bayesian network (DBN), radar model, and threat assessment model to extract crucial information regarding maneuver occupancy, silent penetration, and attack tendency. The extracted information would make great contribution to the recognition accuracy of six types of cooperative tactics. Finally, we learn a decision tree model on train samples processed by above two phases to classify different tactical intention. In order to verify the effectiveness of the proposed method, we use data sets from a loop simulation platform. The experimental results have approved the superiority of our method via the comparison to several baseline methods with respect to recognition rate and efficiency. In addition, we underline that our method also performs well on incomplete and uncertain information.
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Di Bella, Gianluca, Fabio Minutoli, Antonino Recupero, Carmelo Anfuso, Salvatore Patanè, Emanuele Scribano, Francesco Arrigo, and Sebastiano Coglitore. "Cerebral transient ischemic attack due to left ventricular thrombus formation in a young patient with silent myocardial infarction and normal coronary arteries." International Journal of Cardiology 132, no. 2 (February 2009): 293–95. http://dx.doi.org/10.1016/j.ijcard.2007.08.070.
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Li, W., W. Fan, J. Zhu, Z. Chen, and F. Liu. "SAT0560 THE PROGNOSTIC VALUE OF ULTRASONOGRAPHIC FINDINGS IN INDIVIDUALS WITH ASYMPTOMATIC HYPERURICEMIA." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1238.2–1238. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4253.
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Background:Chronic and steady asymptomatic hyperuricemia (AHU) can eventually lead to the deposition of monosodium urate crystals in joints and soft tissues. The rate of progression from AHU to clinically evident gout varies and mainly depends on serum uric acid levels. However, little is known about the prognostic value of ultrasonographic findings in individuals with AHU in detail.Objectives:To explore the prognostic value of ultrasonographic findings in individuals with asymptomatic hyperuricemia.Methods:We analyzed the ultrasonographic findings (snowstorm sign, double-contour (DC) sign, tophi, bone erosion, and abnormal blood flow) of bilateral knees, ankles and the first metatarsal-phalangeal joints (1st MTP) of individuals with AHU at Peking University People’s hospital between June 2014 and May 2016. All individuals were followed up for two years.Results:Among 218 individuals with AHU, the prevalence of snowstorm sign, DC sign, tophi, bone erosion and abnormal blood flow was 41%, 23%, 4%, 9% and 13%, respectively. Gout attacked in 36 patients during 2-year follow-up with 4.5 years of HU duration. The first attack affected the 1st MTP in 60%, the ankle in 31%, and the knee in 11% of the patients with gout. Patients with gout attack has longer hyperuricemia duration compared with individuals with AHU without gout attack. DC sign, tophi, and bone erosion on ultrasound were more frequently presented in patients with gout attack compared with individuals with AHU without gout attack. However, the prevalence of snowstorm sign and and abnormal blood flow on ultrasound has no significant differences between patients with gout attack and individuals with AHU without gout attack.Conclusion:Longer hyperuricemia duration, DC sign, tophi, and bone erosion on ultrasound in individuals with AHU could be associated with gout attack.References:[1]Neogi T, Jansen TL, Dalbeth N, Fransen J, Schumacher HR, Berendsen D, et al. 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2015;74(10):1789-98.[2]Estevez-Garcia IO, Gallegos-Nava S, Vera-Pérez E, Silveira LH, Ventura-Ríos L, Vancini G, et al. Levels of cytokines and MicroRNAs in individuals with asymptomatic hyperuricemia and ultrasonographic findings of gout: A Bench-to-Bedside Approach. Arthritis Care Res. 2018;70(12):1814-21.[3]Elsaman AM, Muhammad EM, Pessler F. Sonographic findings in gouty arthritis: diagnostic value and association with disease duration. Ultrasound Med Biol. 2016;42(6):1330-6.[4]Joosten LAB, Crişan TO, Bjornstad P, Johnson RJ. Asymptomatic hyperuricaemia: a silent activator of the innate immune system. Nat Rev Rheumatol. 2020;16(2):75-86.Acknowledgments:This work was supported by National Natural Science Foundation of China (No. 81571684 to Jiaan Zhu), Peking University People’s Hospital Research and Development Funds (RDC2014-02 to Wenting Fan).Disclosure of Interests:None declared
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Mitrega, Katarzyna, Gregory Y. H. Lip, Beata Sredniawa, Adam Sokal, Witold Streb, Karol Przyludzki, Tomasz Zdrojewski, et al. "Predicting Silent Atrial Fibrillation in the Elderly: A Report from the NOMED-AF Cross-Sectional Study." Journal of Clinical Medicine 10, no. 11 (May 26, 2021): 2321. http://dx.doi.org/10.3390/jcm10112321.
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Background: Silent atrial fibrillation (SAF) is common and is associated with poor outcomes. Aims: to study the risk factors for AF and SAF in the elderly (≥65 years) general population and to develop a risk stratification model for predicting SAF. Methods: Continuous ECG monitoring was performed for up to 30 days using a vest-based system in a cohort from NOMED-AF, a cross-sectional study based on a nationwide population sample. The independent risk factors for AF and SAF were determined using multiple logistic regression. ROC analysis was applied to validate the developed risk stratification score. Results: From the total cohort of 3014 subjects, AF was diagnosed in 680 individuals (mean age, 77.5 ± 7.9; 50.1% men) with AF, and, of these, 41% had SAF. Independent associations with an increased risk of AF were age, male gender, coronary heart disease, thyroid diseases, prior ischemic stroke or transient ischemic attack (ICS/TIA), diabetes, heart failure, chronic kidney disease (CKD), obesity, and NT-proBNP >125 ng/mL. The risk factors for SAF were age, male gender, ICS/TIA, diabetes, heart failure, CKD, and NT-proBNP >125 ng/mL. We developed a clinical risk scale (MR-DASH score) that achieved a good level of prediction in the derivation cohort (AUC 0.726) and the validation cohort (AUC 0.730). Conclusions: SAF is associated with various clinical risk factors in a population sample of individuals ≥65 years. Stratifying individuals from the general population according to their risk for SAF may be possible using the MR-DASH score, facilitating targeted screening programs of individuals with a high risk of SAF.
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Ito, Ayaka, Shinichi Iwata, Soichiro Tamura, Andrew T. Kim, Shinichi Nonin, Sera Ishikawa, Asahiro Ito, et al. "Prevalence and Risk Factors of Silent Brain Infarction in Patients with Aortic Stenosis." Cerebrovascular Diseases Extra 10, no. 3 (October 8, 2020): 116–23. http://dx.doi.org/10.1159/000510438.
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<b><i>Introduction:</i></b> Silent brain infarction (SBI) is an independent risk factor for subsequent symptomatic stroke in the general population. Although aortic stenosis (AS) is also known to be associated with an increased risk of future symptomatic stroke, little is known regarding the prevalence and risk factors for SBI in patients with AS. <b><i>Methods:</i></b> The study population comprised 83 patients with severe AS with no history of stroke or transient ischemic attack and paralysis or sensory impairment (mean age 75 ± 7 years). All patients underwent brain magnetic resonance imaging to screen for SBI and multidetector-row computed tomography to quantify the aortic valve calcification (AVC) volume. Comprehensive transthoracic and transesophageal echocardiography were performed to evaluate left atrial (LA) abnormalities, such as LA enlargement, spontaneous echo contrast, or abnormal LA appendage emptying velocity (<20 cm/s), and complex plaques in the aortic arch. <b><i>Results:</i></b> SBI was detected in 38 patients (46%). Multiple logistic regression analysis indicated that CHA<sub>2</sub>DS<sub>2</sub>-VASc score and estimated glomerular filtration rate (eGFR) were independently associated with SBI (<i>p</i> < 0.05), whereas LA abnormalities and AVC volume were not. When patients were divided into 4 groups according to CHA<sub>2</sub>DS<sub>2</sub>-VASc score and eGFR, the group with a higher CHA<sub>2</sub>DS<sub>2</sub>-VASc score (≥4) and a lower eGFR (<60 mL/min/1.73 m<sup>2</sup>) had a greater risk of SBI than the other groups (<i>p</i> < 0.05). <b><i>Conclusion:</i></b> These findings indicate that AS is associated with a high prevalence of SBI, and that the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and eGFR are useful for risk stratification.
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Juryńczyk, Maciej, Anu Jacob, Kazuo Fujihara, and Jacqueline Palace. "Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: practical considerations." Practical Neurology 19, no. 3 (December 8, 2018): 187–95. http://dx.doi.org/10.1136/practneurol-2017-001787.
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The field of central nervous system (CNS) inflammatory diseases has recently broadened to include a new condition associated with pathogenic serum antibodies against myelin oligodendrocyte glycoprotein (MOG). This is distinct from multiple sclerosis (MS) and aquaporin-4 (AQP4) antibody neuromyelitis optica spectrum disorders (NMOSD). MOG antibody-associated disease phenotypes are varied and range from classical neuromyelitis optica to acute demyelinating encephalomyelitis and cortical encephalitis. The diagnosis depends on using a reliable, specific and sensitive assay of the antibody. Clinical and imaging features of MOG-associated syndromes overlap with AQP4 antibody NMOSD but can be usually distinguished from MS: in particular, the silent lesions typical of MS that progressively increase lesion volume are rare in MOG antibody disease. The disease can relapse but medium-term immunosuppression appears to be protective. Permanent disability, particularly severe ambulatory and visual disability, is less frequent than in AQP4 antibody NMOSD and usually results from the onset attack. However, sphincter and sexual dysfunction after a transverse myelitis is common. Here we review the practical aspects of diagnosing and managing a patient with MOG antibody-associated disease.
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Muwarni, Arita, and Sarni Anggoro. "The Effect of Murottal Therapy on Blood Pressure in Elderly Patients With Hypertension at Jambidan Posyandu, Banguntapan 1 Community Health Center." JOURNAL OF NONCOMMUNICABLE DISEASES 3, no. 1 (April 30, 2023): 8. http://dx.doi.org/10.52365/jond.v3i1.440.
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Hypertension is a non-communicable disease that poses a threat to people in developing countries. Hypertension is a cause of death, called the silent killer, and is mostly suffered by the elderly. This is caused by physiological factors, namely decreased body function due to the aging process, so that non-communicable diseases attack many elderly people. The global health standard does not only rely on curative measures because most diseases can be prevented by healthy lifestyles and avoiding risky lifestyles. This study aims to determine the effect of murottal therapy on blood pressure in the elderly with hypertension. This study used a quasi-experimental research design using a one-group pre-post test design and a sample size of 34 elderly with the sampling technique of purposive sampling and bivariate analysis using the Wilcoxon test. The result is that murottal therapy has an effect on reducing blood pressure in elderly people with hypertension, with a Wilcoxon signed rank test p-value of 0.000 (P <0.05), so there is an effect of murottal therapy on blood pressure in the elderly with hypertension.
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Galpin, Timothy J. "Alfred Scott McLaren, Silent and Unseen: On Patrol in Three Cold War Attack Submarines. Annapolis: U.S. Naval Institute Press, 2015. 256 pp. $39.95." Journal of Cold War Studies 18, no. 2 (April 2016): 194–95. http://dx.doi.org/10.1162/jcws_r_00628.
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Brinjikji, Waleed, Deena M. Nasr, Christopher P. Wood, and Vivek N. Iyer. "Pulmonary Arteriovenous Malformations Are Associated with Silent Brain Infarcts in Hereditary Hemorrhagic Telangiectasia Patients." Cerebrovascular Diseases 44, no. 3-4 (2017): 179–85. http://dx.doi.org/10.1159/000478734.
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Background and Purpose: There is a high prevalence of right-to-left shunting pulmonary arteriovenous malformations (PAVMs), which are stroke risk factors, in hereditary hemorrhagic telangiectasia (HHT) patients. While the prevalence of ischemic complications in HHT patients is known, the prevalence of silent brain infarcts (SBI) remains unknown. The purpose of this study was to determine the prevalence and risk factors for SBI in HHT patients. Materials and Methods: Our institutional HHT database was queried to identify HHT patients who received a baseline screening brain MRI from January 2000 to February 2017. This study group was further refined by excluding patients who had a history of clinical ischemic disease as defined by having a stroke or transient ischemic attack (TIA). Brain MRIs were reviewed for SBI. Baseline data on demographics, Curacao criteria, presence of PAVMs, and cardiovascular risk factors were collected. The primary outcome was SBI prevalence. We also examined which baseline patient characteristics were associated with SBI through univariate chi-square and Student t tests and multivariate logistic regression analyses. Results: Three hundred fifty three consecutive HHT patients from January 2000 to February 2017 with a screening brain MRI and no prior history of stroke/TIA were included. SBI prevalence was 9.9% (35/353). SBI patients were more likely to have PAVMs than non-SBI patients (80.6 vs. 53.1%, p = 0.005). The median age was 66 in the SBI group and 52 in the non-SBI group (p = 0.006). SBI patients had higher prevalence of hyperlipidemia (34.3 vs. 9.8%, p < 0.0001), hypertension (48.6 vs. 22.0%, p = 0.005), and tobacco use (25.7 vs. 9.8%, p = 0.005). No patients under 30 had SBI. In the 60-69 age group, the prevalence of SBI was 18.8% with rates of 28.6% in the PAVM group and 10.5% in the non-PAVM group. For patients ≥70 years old, the prevalence of SBI was 21.4% overall and 27.6% in the PAVM group and 10.5% in the non-PAVM group. On multivariate analysis, PAVMs (OR 3.62, 95% CI 1.46-10.40) and increasing age (OR 1.04, 95% CI 1.01-1.07) were independently associated with SBI. Conclusions: Overall, a similar 10% SBI prevalence in the HHT cohort was noted as compared to the general population. However, the prevalence of SBI was higher in HHT patients with PAVMs when compared to that of the general population, particularly among patients than 60 years old. These findings highlight the need to accurately identify, and when appropriate, treat PAVMs in the HHT population especially given the multiple significant, clinical consequences of SBI.
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Zivkovic, Nenad, Marko Markovic, and Milan Spaic. "Convexity meningioma associated with depression: A case report." Srpski arhiv za celokupno lekarstvo 142, no. 9-10 (2014): 586–88. http://dx.doi.org/10.2298/sarh1410586z.
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Introduction. Meningiomas are slow growing, extra-axial lesions, and can be neurologically silent for a long time and present only with depression. Case Outline. A 65-year-old woman developed major depression and was treated with antidepressants for two years. Depression failed to respond to drug treatment and there was no improvement. Two months before admission to hospital, due to the onset of epilepsy attack the patient underwent reinvestigation, and a large temporal convexity meningioma, which corresponded in position to the original electroencephalography focus, was diagnosed using the computer topography of the brain. The patient underwent osteoplastic craniotomy, and a left fronto-temporal convexity meningioma of 5 cm in diameter was completely removed with its attachment to the dura. Histological examination confirmed a fibroblastic meningioma. Conclusion. Total resection of convexity meningioma and decompression of the brain tissue in the region of limbic pathways that are involved, may contribute to a complete remission of depression symptoms. This case also illustrates the need for a prompt neuroimaging of the brain when patients present any atypical psychiatric symptoms, with late onset (>50 years old) of the first depressive episode or fast changes of the mental state.
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Irawan, Dudi, Izzati Muhimmah, and Tito Yuwono. "PROTOTYPE SMART INSTRUMENT UNTUK KLASIFIKASI PENYAKIT HIPERTENSI BERDASARKAN JNC-7." Jurnal Teknologi Informasi dan Terapan 4, no. 2 (April 1, 2019): 111–18. http://dx.doi.org/10.25047/jtit.v4i2.68.
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High blood disease or famous to known as hypertension almost 95% the cause is very difficult to know. One way to know the condition of our health is by checking routine to the nearest clinic or hospital. Hypertension is one of the risk factors for dangerous diseases, such as stroke, heart attack, and kidney failure. Hypertension can cause high morbidity (pain) and mortality (death), hypertension is often called silent killer disease. People with Hypertension rarely show early symptoms, and their recognition is usually through screening, or when seeking medical treatment for unrelated health problems. The cause factors of hypertension include weight and height, body fat, and alcohol levels inside of body. To know the condition of body to hypertension need a monitoring system and use tool tensimeter. In this research has been made the means of detecting factor symptoms of hypertension. After the measurements are done by each sensor then the data is processed by Arduino Microcontroller to be processed to computer via serial port (USB). On the computer data that has been sent will be processed using decision tables with databases obtained from experts, the resultin a decision will give classification of hypertension and non-pharmacological management.
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Díez González, María del Carmen, and Rafael Marcos Sánchez. "The impact of fear in the post covid era." Journal of Neurology & Stroke 11, no. 6 (December 13, 2021): 186–89. http://dx.doi.org/10.15406/jnsk.2021.11.00484.
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Feeling fear is involuntary, as it is often unconscious. However, there are other faces of fear that we can recognize and that are familiar to us. We go from real fears to unreal fears, from present fears to projective fears that are reinforced and mutate into other more complex situations that further reinforce our fear. The more we reinforce these thoughts the stronger our fear becomes. So, what is feeding our fear? How do we react to fear? Is it the desire to dodge the blow, to strike back, to attack it? Fear is a very powerful mechanism that should only be activated in dangerous situations. If we use fear for educational purposes we will project very deep blockages in the new generations. However, when we recognize and accompany the thoughts and impulses generated by fear, they become silent. Once silenced, they are no longer activated unconsciously. Therefore, if we look at what is happening, consciously, "without judgement" it will facilitate our journey towards our true SELF. The EmocionaTFamilia program invites us to accompany our path "lightly and at the right time". Change is simple, the lesson is the opposite of what we have learned.
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Sukma, Haria, Emy Yuliantini, and Tetes Wahyu Witradharma. "The Occurrence of Hypertension in Adult Groups of Fishermen Families." Jurnal Ilmu dan Teknologi Kesehatan 7, no. 2 (March 31, 2020): 104–14. http://dx.doi.org/10.32668/jitek.v7i2.219.
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Hypertension is often called a silent killer because it triggers other deadly diseases and increases the risk of heart attack, heart failure, stroke, and renal failure. Risk factors of hypertension are genes, gender, age, race, obesity, sodium consumption, smoking, alcohol, less physical activity, stress, and caffeine consumption. The purpose of this research is to know the relationship of age, sodium consumption, body mass index (BMI), the ratio of hip waist circumference (RLPP) with the incidence of hypertension in adult groups of fishermen in the work area fish Market Puskesmas Kota Bengkulu Year 2019. The study used a descriptive-analytical design with a cross-sectional approach. The technique used is purposive sampling, with a sample number of 45 people aged (26-45 years). Statistical analysis is a chi-square test and logistics regression test. The results indicate the absence of age relations and RLPP with the incidence of hypertension (P-value > 0.05), there are IMT relations and sodium consumption with the prevalence of hypertension (p-value ≤ 0.05) and the most influential factor in the incidence hypertension, sodium ingestion (p-value 0.0005; OR 206, 28). Researchers advise people to reduce the consumption of high sodium foods.
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Evans, Matthew. "Plato's Rejection of Thoughtless and Pleasureless Lives." Phronesis 52, no. 4 (2007): 337–63. http://dx.doi.org/10.1163/156852807x229249.
Full textAbstract:
AbstractIn the Philebus Plato argues that every rational human being, given the choice, will prefer a life that is moderately thoughtful and moderately pleasant to a life that is utterly thoughtless or utterly pleasureless. This is true, he thinks, even if the thoughtless life at issue is intensely pleasant and the pleasureless life at issue is intensely thoughtful. Evidently Plato wants this argument to show that neither pleasure nor thought, taken by itself, is sufficient to make a life choiceworthy for us. But there is some disagreement among commentators about whether or not he also wants the argument to show why. Is the argument designed to establish that we should reject thoughtless and pleasureless lives because some pleasures and some thoughts are goods? Or is it silent on this issue? Many interpreters take the first option, claiming that Plato uses the argument to attack both the hedonist view that only pleasures are goods and the intellectualist view that only thoughts are goods. My aim in this paper is to show that the second option is at least as attractive as the first, both exegetically and philosophically.