Books: 'Significant molecules'

1

Smyth, W. Franklin. Voltammetric determination of molecules of biological significance. Chichester, West Sussex, England: New York, 1992.

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2

Doggett, Thad H. Menstruation: Origin and evolutionary significance. New York: Vantage Press, 1995.

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3

Jochen, Klein, Löffelholz Konrad, and International Cholinergic Symposium (9th : 1995 : Mainz, Rhineland-Palatinate, Germany), eds. Cholinergic mechanisms: From molecular biology to clinical significance. Amsterdam: Elsevier, 1996.

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4

Symposium on Mechanisms and Biological Significance of Pulsatile Hormone Secretion (1999 : London, England), ed. Mechanisms and biological significance of pulsatile hormone release. Chichester, West Sussex, England: Wiley, 2000.

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5

Z, Langer S., ed. Serotonin receptor subtypes: Pharmacological significance and clinical implications. Basel: Karger, 1992.

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6

Emel, Arinç, Schenkman John B, Hodgson Ernest 1932-, and NATO Advanced Study Institute on Molecular Aspects of Drug Metabolizing Enzymes (1993 : Kus̜adası, Turkey), eds. Molecular aspects of oxidative drug metabolizing enzymes: Their significance in environmental toxicology, chemical carcinogenesis, and health. Berlin: Springer-Verlag, 1995.

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7

NATO Advanced Study Institute on Molecular Aspects of Drug Metabolizing Enzymes (1993 Kuşadası, Turkey). Molecular aspects of oxidative drug metabolizing enzymes: Their significance in environmental toxicology, chemical carcinogenesis, and health. Berlin: Springer-Verlag,in cooperation with NATO Scientific Affairs Division, 1995.

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8

Cherdanceva, Tat'yana, Vladimir Klimechev, and Igor' Bobrov. Pathological and molecular biological analysis of renal cell carcinoma. Diagnosis and prognosis. ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1020785.

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The monograph is devoted to the study of pathomorphological and molecular-biological characteristics of renal cell carcinoma and peritumoral zone depending on the degree of malignancy, and determine prognostic significance of criteria for predicting the postoperative survival of patients. Of interest to urologists, oncologists, pathologists, researchers, graduate students, dealing with the diagnosis of renal cell carcinoma and subsequent prediction of postoperative survival of patients.

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9

Puhal'skiy, Vitaliy. Introduction to Genetics. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1019851.

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The textbook outlines the cytological foundations of heredity, the regularities of Mendelian genetics, the chromosomal theory of heredity, the basics of molecular genetics and genetic engineering, the patterns of inheritance during distant hybridization, polyplodia and mutagenesis. Special attention is paid to the heterosis and genetics of populations. A significant part of the data is presented in the form of figures, diagrams, graphs and tables that facilitate the understanding of the material presented. Meets the requirements of the federal state educational standards of higher education of the latest generation. For students of higher educational institutions studying in agronomic specialties.

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10

European Symposium on Calcified Tissues (20th 1987 Sirmione, Italy). XX European Symposium on Calcified Tissues, Sirmione, Italy, October 4-8, 1987: Abstracts, including Satellite Workshop on Molecular and Cell Biology and Satellite Workshop on Biology and Regulation of Bone Metabolism : Clinical Significance. New York: Springer International, 1987.

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11

Tyukavin, Aleksandr. Fundamentals of pathology. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1242551.

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The textbook reveals the concepts of health and disease, presents modern ideas about the causes and conditions of the occurrence of actual types of pathology. The importance of molecular genetic factors of heredity and reactivity in the formation of typical pathological processes is shown. The main regularities and features of manifestations of organ and system dysfunction in various types of pathology are described. Special attention is paid to the causes and mechanisms of development of socially significant diseases of the heart and blood vessels, brain, respiratory organs and other vital systems of the body. A separate section of the textbook provides up-to-date information on first aid. The criteria of safe conditions for first aid are described; the main clinical manifestations of emergency conditions in accidents, injuries, poisoning and diseases are described. A list of first aid measures for life-threatening conditions is presented. The cloud service contains a video of the basic algorithm for conducting cardiopulmonary resuscitation in a pharmacy or office. It is written in accordance with the program of the academic discipline "Fundamentals of Pathology" in the specialty 33.02.01 "Pharmacy" and refers to the educational and methodological publications of the cycle of general professional disciplines for students of pharmaceutical technical schools.

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12

Sivasankar, Shoba, Noel Ellis, Ljupcho Jankuloski, and Ivan Ingelbrecht, eds. Mutation breeding, genetic diversity and crop adaptation to climate change. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0000.

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Abstract This book presents reviews on the application of the technology for crop improvement towards food and nutrition security, and research status on mutation breeding and associated biotechnologies in both seed crops and vegetatively propagated crops. It also presents perspectives on the significance of next-generation sequencing and bioinformatics in determining the molecular variants underlying mutations and on emerging biotechnologies such as gene editing. Reviews and articles are organized into five sections in the publication: (1) Contribution of Crop Mutant Varieties to Food Security; (2) Mutation Breeding in Crop Improvement and Climate-Change Adaptation; (3) Mutation Induction Techniques for Enhanced Genetic Variation; (4) Mutation Breeding in Vegetatively Propagated and Ornamental Crops; and (5) Induced Genetic Variation for Crop Improvement in the Genomic Era. The contents of this volume present excellent reference material for researchers, students and policy makers involved in the application of induced genetic variation in plants for the maintenance of biodiversity and the acceleration of crop adaptation to climate change to feed a growing global population in the coming years and decades.

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13

Szudy, Józef. 100 lat optyki na Uniwersytecie Warszawskim (1921–2021). University of Warsaw Press, 2021. http://dx.doi.org/10.31338/uw.9788323550211.

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This publication is related to the centenary of physics at the University of Warsaw. It describes the history of optics at the university since 1921, when Stefan Pieńkowski founded the Division of Physics at 69 Hoża Street in Warsaw. The author reports on the rapid development of research and significant discoveries in this field in the interwar period, when the Division of Physics earned a reputation as a world centre for molecular luminescence and atomic spectroscopy, attracting scientists from all over the world to Warsaw. Rebuilt after World War II, it got a new image when lasers were used for studies on the structure of atoms and molecules as well as atomic collisions. Today, it has become an internationally recognised modern centre for optical physics, including nonlinear optics, Fourier optics, plasmonics and quantum technologies.

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14

Dunlop, Storm. 4. Water in the atmosphere. Oxford University Press, 2017. http://dx.doi.org/10.1093/actrade/9780199571314.003.0004.

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Among the planets in the Solar System, Earth is unique in possessing large quantities of water, and water’s properties are highly significant in determining weather. This is because water readily exists in three different phases (ice, liquid water, and water vapour) at temperatures frequently encountered on Earth. ‘Water in the atmosphere’ explains humidity and saturation: the number of molecules of water vapour in the air is determined solely by temperature. Unstable conditions lead to the formation of cumuliform clouds and precipitation is created by either glaciation or coalescence. There are three groups of clouds—cumuliform, stratiform, and cirriform—with ten types of cloud identified based on their altitude and structure.

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15

1937-, Jost J. P., and Saluz H. P. 1952-, eds. DNA methylation: Molecular biology and biological significance. Basel: Birkhäuser Verlag, 1992.

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16

Jost, J., and H. Saluz. DNA Methylation: Molecular Biology and Biological Significance. Birkhauser Verlag, 2013.

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17

Jost, J. Dna Methylation: Molecular Biology And Biological Significance. Springer, 2011.

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18

Webb, Andrew. Colloids in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0056.

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Colloid solutions are homogenous mixtures of large molecules suspended in a crystalloid solution. The efficacy of colloids as volume substitutes or expanders, and length of effect are determined by their physicochemical properties. Smaller volumes of colloid than crystalloid are required for resuscitation. The primary use of colloids is in the correction of circulating volume. Rather than using fixed haemodynamic endpoints, fluid can be given in small aliquots with assessment of the dynamic haemodynamic response to each aliquot. The aim of a fluid challenge is to produce a small, but significant (200 mL) and rapid increase in plasma volume with changes in central venous pressure or stroke volume used to judge fluid responsiveness. Colloid fluids give a reliable increase in plasma volume to judge fluid responsiveness.

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19

Zaheer Ul-Haq and Angela K. Wilson, eds. Frontiers in Computational Chemistry: Volume 6. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150368481220601.

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Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. The sixth volume of this series features these six different perspectives on the application of computational chemistry in rational drug design: 1. Computer-aided molecular design in computational chemistry 2. The role of ensemble conformational sampling using molecular docking & dynamics in drug discovery 3. Molecular dynamics applied to discover antiviral agents 4. Pharmacophore modeling approach in drug discovery against the tropical infectious disease malaria 5. Advances in computational network pharmacology for Traditional Chinese Medicine (TCM) research 6. Progress in electronic-structure based computational methods: from small molecules to large molecular systems of biological significance

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20

Conrad, M. Adaptability: The Significance Of Variability From Molecule To Ecosystem. Springer, 2012.

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21

Conrad, M. Adaptability: The Significance of Variability from Molecule to Ecosystem. Springer London, Limited, 2012.

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22

Conrad, M. Adaptability: The Significance of Variability from Molecule to Ecosystem. Springer My Copy UK, 2012.

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23

Klein, J., and K. Löffelholz. Cholinergic Mechanisms: From Molecular Biology to Clinical Significance. Elsevier Science & Technology Books, 1996.

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24

Cedar, Aharon Razin Howard. DNA Methylation: Biochemistry and Biological Significance. Springer New York, 2011.

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25

Jost, J., and H. Saluz. DNA Methylation: Molecular Biology and Biological Significance (Experientia Supplementum). Birkhauser, 1992.

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26

Smyth, W. Franklin. The electroanalysis of selected organic, organometallic and inorganic molecules of biological significance. 1985.

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27

Barros, Rodrigo José Saraiva de, Tereza Cristina de Brito Azevedo, Carla de Castro Sant’Anna, Marianne Rodrigues Fernandes, Leticia Martins Lamarão, and Rommel Mario Rodríguez Burbano. Grupos sanguíneos e anticorpos anti-eritrocitários de importância transfusional. Brazil Publishing, 2020. http://dx.doi.org/10.31012/978-65-5861-112-7.

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Immunohematology is an area dedicated to the study of the interactions of the immune system and blood cells in transfusion practice. Blood transfusion is a therapeutic technique that has been widely used since the 17th century. The transfusion medicine aims to repair the pathological needs of blood components in the living organism, be it red blood cells, plasma, platelets, clotting factors, among others. Despite being a therapeutic means, transfusion of blood components can be considered at risk because it is a biological material and due to the transfusion immunological reactions that can be caused during or after the moment of transfusion. In the surface structure of red blood cells, numerous molecules of a protein, glycoprotein or glycolipid nature are found, which are also called membrane antigens that make up structures and perform transport functions, as receptors, as adhesion, enzymatic and / or complement regulatory molecules. The formation of these antigens occurs by an approximate amount of 39 genes involved in their production, of which 282 different antigens are organized in more than 30 blood group systems. This antigenic diversity is a major cause of the formation of irregular anti-erythrocyte antibodies. Therefore, with the increase in blood transfusions in surgeries, transplants and clinical treatment of cancer and other chronic diseases, a significant increase in the occurrence of alloimmunizations in polytransfused patients began to be observed. Such biological phenomena motivated us to carry out this study and the antigenic diversity motivated us to elaborate this small compendium where we also describe the main blood groups.

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28

Schrader, Michael, and Markus Islinger, eds. Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation. Frontiers Media SA, 2017. http://dx.doi.org/10.3389/978-2-88945-104-3.

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29

Phenotypic Plasticity: Molecular Mechanisms, Evolutionary Significance and Impact on Speciation. Nova Science Pub Inc, 2013.

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30

Jost, J. P. DNA Methylation: Molecular Biology and Biological Significance (Exs (Experientia Supplementum)). Birkhauser, 1993.

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31

Fragoulis, George E., and Iain B. McInnes. Small molecules in the treatment of psoriatic arthritis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0031.

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Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, occurring in about one third of psoriasis patients, and exhibiting very varied clinical manifestations and comorbidities. Although the clinical outcome of the disease has been significantly improved recently, mainly due to utilization of novel agents targeting the IL-23/-17 axis, unmet needs still exist. Emerging insights into the disease’s pathogenesis led to development of new drugs acting against critical molecular targets and their efficacy in psoriasis and/or PsA has been tested in Phase III clinical trials. Some of these therapeutic regimens have been already approved; some look promising but others have been proven inefficacious. Future studies are expected to determine the place of these compounds within the therapeutic algorithm of PsA. In this chapter we describe the rationale and clinical impact of incorporating small molecules in PsA treatment, as well as specific molecules involved in pathogenesis that may serve as therapeutic targets.

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32

The role of the inhibitory molecule l[kappa]B[alpha] in teh priming of lung injury after resuscitated hemorrhagic shock: Molecular mechanisms and significance. Ottawa: National Library of Canada, 2003.

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33

(Editor), J. Klein, and K. Löffelholz (Editor), eds. Cholinergic Mechanisms: From Molecular Biology to Clinical Significance (Progress in Brain Research). Elsevier Science, 1996.

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34

(Editor), S. Mancuso, and S. Shabala (Editor), eds. Rhythms in Plants: Phenomenology, Mechanisms, and Adaptive Significance. Springer, 2007.

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35

Levin, Frank S. Surfing the Quantum World. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198808275.001.0001.

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Surfing the Quantum World bridges the gap between in-depth textbooks and typical popular science books on quantum ideas and phenomena. Among its significant features is the description of a host of mind-bending phenomena, such as a quantum object being in two places at once or a certain minus sign being the most consequential in the universe. Much of its first part is historical, starting with the ancient Greeks and their concepts of light, and ending with the creation of quantum mechanics. The second part begins by applying quantum mechanics and its probability nature to a pedagogical system, the one-dimensional box, an analog of which is a musical-instrument string. This is followed by a gentle introduction to the fundamental principles of quantum theory, whose core concepts and symbolic representations are the foundation for most of the subsequent chapters. For instance, it is shown how quantum theory explains the properties of the hydrogen atom and, via quantum spin and Pauli’s Exclusion Principle, how it accounts for the structure of the periodic table. White dwarf and neutron stars are seen to be gigantic quantum objects, while the maximum height of mountains is shown to have a quantum basis. Among the many other topics considered are a variety of interference phenomena, those that display the wave properties of particles like electrons and photons, and even of large molecules. The book concludes with a wide-ranging discussion of interpretational and philosophic issues, introduced in Chapters 14 by entanglement and 15 by Schrödinger’s cat.

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36

Bernstein, Joel. Polymorphism in Molecular Crystals. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780199655441.001.0001.

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First recognized in 1822, polymorphism of crystals is now a widely recognized and observed phenomenon, with both fundamental and commercial ramifications in disciplines and industries that study and utilize solid forms of matter. The purpose of this edition is to summarize and to bring up to date the current knowledge and understanding of polymorphism in molecular crystals, and to concentrate it in one source. The information has been gleaned from a wide variety (~2500) of sources in the open literature; however, because of the increasing commercial importance of the phenomenon, a significant portion of the information is less accessible, we have attempted to include both the information from those sources as well with full details of their citations. An introductory chapter on fundamental concepts, definitions, and historical development is followed by a presentation of the physical and structural bases for crystallization and polymorphism. The exploration of the crystal form landscape is described in detail, including polymorph screens, concomitant polymorphs, and disappearing polymorphs. A survey of analytical methods for studying and characterizing polymorphs is followed by a discussion of rapidly developing computational methods for studying and attempting to predict polymorphic behavior. A chapter with many examples of the utilization of polymorphic systems to investigate structure–property relationships in solids precedes three individual chapters on the role and importance of polymorphism in pharmaceuticals, high energy materials, and pigments. The book closes with a chapter on the role of polymorphism in establishing and protecting intellectual property connected with polymorphs through the patent system.

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37

Gabriel, Roland, and Emel Arinç John B. Schenkman. Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health. Springer, 2011.

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38

Arinc, Emel, John B. Schenkman, and Ernest Hodgson. Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health. Springer London, Limited, 2013.

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39

Kotzer, Katrina E., and Sarah E. Kerr. Molecular Technologies and Test Issues. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190604929.003.0005.

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Molecular genetic testing has been around since the discovery and offering of clinical testing for the first gene sequenced. However, in recent years the methods and scope of molecular genetic testing have evolved significantly to encompass next-generation sequencing, multigene panels, and whole exome and genome testing. With this evolution in molecular methods, the nomenclature and variant evaluation and annotation processes are crucial for the systematic and standard interpretation of molecular test results. This chapter will provide the laboratory genetic counselor with information about the common sample types analyzed by molecular techniques for the purposes of genetic testing and the various methodologies available and their limitations. Guidelines are given for the standard approach to molecular variant reporting with respect to nomenclature and variant classification.

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40

Sapse, Anne-Marie, ed. Molecular Orbital Calculations for Biological Systems. Oxford University Press, 1998. http://dx.doi.org/10.1093/oso/9780195098730.001.0001.

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Molecular Orbital Calculations for Biological Systems is a hands-on guide to computational quantum chemistry and its applications in organic chemistry, biochemistry, and molecular biology. With improvements in software, molecular modeling techniques are now becoming widely available; they are increasingly used to complement experimental results, saving significant amounts of lab time. Common applications include pharmaceutical research and development; for example, ab initio and semi-empirical methods are playing important roles in peptide investigations and in drug design. The opening chapters provide an introduction for the non-quantum chemist to the basic quantum chemistry methods, ab initio, semi-empirical, and density functionals, as well as to one of the main families of computer programs, the Gaussian series. The second part then describes current research which applies quantum chemistry methods to such biological systems as amino acids, peptides, and anti-cancer drugs. Throughout the authors seek to encourage biochemists to discover aspects of their own research which might benefit from computational work. They also show that the methods are accessible to researchers from a wide range of mathematical backgrounds. Combining concise introductions with practical advice, this volume will be an invaluable tool for research on biological systems.

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41

Higginbotham, James. Languages and Idiolects: Their Language and Ours. Edited by Ernest Lepore and Barry C. Smith. Oxford University Press, 2009. http://dx.doi.org/10.1093/oxfordhb/9780199552238.003.0006.

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An idiolectal conception of language is compatible with a substantive role for external things — objects, including other people — in the characterization of idiolects. Illustrations of this role are not hard to come by. The point of looking outward from the individual is pretty evident for the case of reference to perceptually encountered objects: had the world been significantly different, a person with the same molecular history would have acquired, and called by the same familiar names, different physical and other concepts. An idiolectal conception of language is by no means committed, and has some reason to be opposed, to internalism, and to individualism in Burge's sense; that is, to the view that the organization of the body, abstracting from external things, is constitutive of any linguistically significant aspect of language.

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42

Divan, Aysha, and Janice A. Royds. 9. Future challenges. Oxford University Press, 2016. http://dx.doi.org/10.1093/actrade/9780198723882.003.0009.

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Advances in molecular biology provide us with opportunities for tackling chronic global issues. ‘Future challenges’ discusses two areas of molecular biology that will have significant impact on society in the coming years: non-communicable diseases and synthetic biology. Molecular biology is being applied to some of the most serious challenges facing our future health and longevity. These are the obesity epidemic, personalized medicine, and the impact of genetic diseases. Synthetic biology combines genetic engineering techniques with the practical principles of engineering to design and build new biological systems or organisms with novel or enhanced properties. What are the ethical and social concerns raised by this advancing technology?

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43

Connor, Thomas, and Patrick H. Maxwell. Molecular basis of renal tumour syndromes. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0328.

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Kidney cancer is among the most common adult malignancy. It accounts for over 3% of all new cases of cancer diagnosed in men and around 2% of all cancers in women in the United Kingdom. In the United States, 1 in 75 people will develop renal cancer in their lifetime and approximately one-third will have metastatic disease at presentation. Kidney cancer has a notoriously poor response to chemotherapy and radiotherapy, but treatment has evolved significantly in the past 10 years. Key to these recent developments in therapy has been a revolution in our understanding of the molecular basis of the renal tumour syndromes which are described in this chapter. Two to three per cent of cases of renal cancer are recognized as due to these syndromes, but they are likely to be recurrent, and to occur in other family members. Seven genes are currently implicated in these syndromes.

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44

Mechanisms and Biological Significance of Pulsatile Hormone Secretion (Novartis Foundation Symposia). Wiley, 2000.

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45

Jarnecke, Amber M., and Susan C. South. Behavior and Molecular Genetics of the Five Factor Model. Edited by Thomas A. Widiger. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199352487.013.25.

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Behavior and molecular genetics informs knowledge of the etiology, structure, and development of the Five Factor Model (FFM) of personality. Behavior genetics uses quantitative modeling to parse the relative influence of nature and nurture on phenotypes that vary within the population. Behavior genetics research on the FFM has demonstrated that each domain has a heritability (proportion of variation due to genetic influences) of 40–50%. Molecular genetic methods attempt to identify specific genetic mechanisms associated with personality variation. To date, findings from molecular genetics are tentative, with significant results failing to replicate and accounting for only a small percentage of the variance. However, newer techniques hold promise for finding the “missing heritability” of FFM and related personality domains. This chapter presents an overview of commonly used behavior and molecular genetic techniques, reviews the work that has been done on the FFM domains and facets, and offers a perspective for future directions.

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46

Sawyer, Donald T., and R. J. P. Williams. Oxygen Chemistry. Oxford University Press, 1992. http://dx.doi.org/10.1093/oso/9780195057980.001.0001.

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This book places oxygen on the center stage of chemistry in a manner that parallels the focus on carbon by 19th century chemists. One measure of the significance of oxygen chemistry is the greater diversity of oxygen-containing molecules than of carbon-containing molecules. One of the most important compounds is water, containing the properties of being a unique medium for biological chemistry and life, the source of all the dioxygen in the atmosphere, and the moderator of the earth's climate. Sawyer first introduces the biological origins of dioxygen and role of dioxygen in aerobic biology and oxidative metabolism, and in separate chapters discusses the oxidation-reduction thermodynamics of oxygen species, and the nature of the bonding for oxygen in its compounds. Additional chapters focus on the reactivities of specific oxygen compounds. The book will be of interest to chemists and biochemists, as well as graduate students, life scientists, and medical researchers.

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47

Bianconi, Ginestra. Multilayer Networks. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198753919.001.0001.

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Multilayer networks are formed by several networks that interact with each other and co-evolve. Multilayer networks include social networks, financial markets, transportation systems, infrastructures and molecular networks and the brain. The multilayer structure of these networks strongly affects the properties of dynamical and stochastic processes defined on them, which can display unexpected characteristics. For example, interdependencies between different networks of a multilayer structure can cause cascades of failure events that can dramatically increase the fragility of these systems; spreading of diseases, opinions and ideas might take advantage of multilayer network topology and spread even when its single layers cannot sustain an epidemic when taken in isolation; diffusion on multilayer transportation networks can significantly speed up with respect to diffusion on single layers; finally, the interplay between multiplexity and controllability of multilayer networks is a problem with major consequences in financial, transportation, molecular biology and brain networks. This field is one of the most prosperous recent developments of Network Science and Data Science. Multilayer networks include multiplex networks, multi-slice temporal networks, networks of networks, interdependent networks. Multilayer networks are characterized by having a highly correlated multilayer network structure, providing a significant advantage for extracting information from them using multilayer network measures and centralities and community detection methods. The multilayer network dynamics (including percolation, epidemic spreading, diffusion, synchronization, game theory and control) is strongly affected by the multilayer network topology. This book will present a comprehensive account of this emerging field.

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48

Zinsstag, J., E. Schelling, J. Solera, J. M. Blasco, and I. Moriyón. Brucellosis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0007.

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Brucellosis has been successfully controlled and eliminated in a number of countries by effective, well managed vaccination and test-slaughter strategies. Their cost was essentially borne by national governments including the cost of acceptable compensation for culled animals. Brucellosis is, however, endemically persisting in livestock and causing human disease in the Mediterranean region, Africa, the Near East and Central America and is re-emerging as a major preventable disease in countries of the former Soviet Union and Mongolia. There has been significant progress in knowledge of the molecular biology of Brucellosis and with new antibiotics for the treatment of human cases. Significantly more efficacious and safe animal vaccines in terms of reduction of transmission are still lacking. Control strategies that have been successful in Western countries are not directly applicable to low income and transition countries because their national governments do not have the finance to compensate farmers and lack the technical capacity for effective control campaigns. However, new staged control approaches in developing economies are proving effective.

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49

Molecular and Cellular Basis for Cell to Cell Interaction: Its Significance in Cancer (Proceedings of the Princess Takamatsu Cancer Research Fund). Princeton Scientific Pub, 1995.

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50

North, Robert, and Ganesh Rao. Medulloblastoma. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0006.

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Medulloblastoma is the most common brain malignancy in children. This chapter details the current diagnostic criteria, pathological classification, and treatment paradigms. Recent molecular characterization of medulloblastoma has revealed significant variations in clinical behavior of different tumor types. While the treatments for medulloblastoma are generally quite successful, with 5 year survival rates approaching 80%, the responsiveness of each subtype to treatment varies. The authors cover common clinical scenarios along with management pearls and key references.

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Books on the topic 'Significant molecules'

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