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Academic literature on the topic 'SHTG'

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Published: 12 May 2023

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Journal articles on the topic "SHTG"

1

Christian, Jennifer B., Maneesh X. Juneja, Amy M. Meadowcroft, Spencer Borden, and Kimberly A. Lowe. "Prevalence, Characteristics, and Risk Factors of Elevated Triglyceride Levels in US Children." Clinical Pediatrics 50, no. 12 (August 3, 2011): 1103–9. http://dx.doi.org/10.1177/0009922811414286.

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Limited information is available on the epidemiology of hypertriglyceridemia (HTG; 150-499 mg/dL) and severe HTG (SHTG; >500 mg/dL) in children. This study estimates the prevalence of HTG and SHTG, evaluates factors that may be associated with these conditions, and describes the use of dyslipidemic agents in children. The sample included children 12 to 19 years old who participated in National Health and Nutrition Examination Survey (NHANES) 2001-2008 (n = 3248) and children 5 to 19 years of age who were part of a large managed-care claims database in the United States (n = 65 258). Results from NHANES confirm the rarity of SHTG in the US pediatric population (ie, 0.2%). Factors statistically significantly associated with having HTG or SHTG in the claims database were being male, 12 to 19 years old, having high low-density lipoprotein (LDL), having low high-density lipoprotein (HDL), diabetes, and psychological disorders. Fibrates were the most commonly prescribed triglyceride-lowering agent among children with SHTG, followed by statins and Lovaza.
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Anand, Neil, Evan Campbell, Tracey Macgann, Joanna Kelly, and Julie Calvert. "PP298 Scottish Health Technologies Group (SHTG) Adaptations: Utilizing Other Agencies’ HTAs In Scotland." International Journal of Technology Assessment in Health Care 37, S1 (December 2021): 34. http://dx.doi.org/10.1017/s0266462321001501.

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IntroductionHealth Technology Assessment (HTA) is an important but time-consuming process to inform decision-making. Following requests from stakeholders in Scotland to provide advice on technologies that had recently undergone HTA in other jurisdictions, SHTG recognized a gap in their ‘product menu’. Colleagues within the SHTG team devised a mechanism through which an original HTA could be adapted for Scotland, taking into account local contextual factors.MethodsSHTG Adaptations comprise the following: i) assessment of the original HTA using the EUnetHTA HTA Adaptation Toolkit and checklist; ii) draft Adaptation using the outcome of the assessment and contextual information for Scotland; iii) consultation group of relevant Scottish clinicians is provided with the original HTA and draft SHTG Adaptation; iv) modified Delphi approach (max. three rounds of questioning) is used to ascertain the relevance of the original HTA to Scotland; v) the Adaptation is submitted to SHTG Council for endorsement.ResultsSHTG Adaptations have a timeline of 2–3 months, three have been published since this product was launched. The process has run smoothly with excellent clinical engagement from across NHS Scotland. Key learning focusses on the role of the SHTG Council (i.e. appraisal committee) in this process and in handling of expert opinion of evidence which has already been appraised by another agency.ConclusionsThe SHTG Adaptation is a new product which offers a timely assessment and utilization of an HTA from another agency.
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Kandulu, Jess. "OP314 What Happened Next? Assessing Health Technology Assessment Impact In Scotland." International Journal of Technology Assessment in Health Care 37, S1 (December 2021): 12. http://dx.doi.org/10.1017/s0266462321000957.

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IntroductionThe Scottish Health Technologies Group (SHTG) set out to assess the impact of HTA products. Two questions were posed: Does advice from SHTG have influence? How is SHTG advice used?MethodsSHTG adapted a tool developed by the International Network of Agencies for Health Technology Assessment (INAHTA). The INAHTA framework investigates indications of impact and categorizes outputs into levels of impact. Over three years, potential users of SHTG advice were contacted six to twelve months after advice was published and asked how the advice had been used. HTA outputs were categorized into the four levels of influence they achieved: ‘major influence’, ‘some influence’, ‘some consideration’ and ‘no known influence’.ResultsHTA products were found to have been used in four main ways: ‘informed discussion’, ‘referenced’, ‘informed policy’ or ‘directly informed practice’. Levels of influence had steadily increased over the three years assessed. The findings were well received by internal audiences, with particular interest in the various ways HTA recommendations had been used. There was also feedback about ‘marking our own homework’. These results have informed a new SHTG strategy and supported clear messaging around the value of HTA.ConclusionsSHTG has found a pragmatic, resource-light way to explore the impact of HTA outputs, which has proved valuable for driving strategy and messaging.
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4

O’Dea, Louis St L., James MacDougall, Veronica J. Alexander, Andres Digenio, Brant Hubbard, Marcello Arca, Patrick M. Moriarty, et al. "Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles." Journal of the Endocrine Society 3, no. 12 (October 11, 2019): 2397–410. http://dx.doi.org/10.1210/js.2019-00214.

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Abstract Context Differentiation between familial chylomicronemia syndrome (FCS, type 1 hyperlipoproteinemia), a rare metabolic disorder, and the more common multifactorial severe hypertriglyceridemia (sHTG, type 5 hyperlipoproteinemia) is challenging because of their overlapping symptoms but important in patient management. Objective To assess whether readily obtainable clinical information beyond triglycerides can effectively diagnose and differentiate patients with FCS from those with sHTG, based on well-curated data from two intervention studies of these conditions. Methods The analysis included 154 patients from two phase 3 clinical trials of patients with sHTG, one cohort with genetically confirmed FCS (n = 49) and one with multifactorial sHTG (n = 105). Logistic regression analyses were performed to determine the ability of variables (patient demographics, medical history, and baseline lipids, individually or in sets) to differentiate the patient populations. Receiver operating characteristics were used to determine the variable sets with the highest accuracy (percentage of times actual values matched predicted) and optimal sensitivity and specificity. Results The primary model diagnosed 45 of 49 patients with FCS and 99 of 105 patients with sHTG correctly. Optimal sensitivity for all available parameters (n = 17) was 91.8%, optimal specificity was 94.3%, and accuracy was 93.5%. Fasting low-density lipoprotein cholesterol (LDL-C) provided the highest individual predictability. However, a three-variable set of ultracentrifugally measured LDL-C, body mass index, and pancreatitis history differentiated the diseases with a near similar accuracy of 91.0%, and adding high-density lipoprotein cholesterol and very low-density lipoprotein cholesterol for a five-variable set provided a small incremental increase in accuracy (92.2%). Conclusions In the absence of genetic testing, hypertriglyceridemic patients with FCS and sHTG can be differentiated with a high degree of accuracy by analyzing readily obtainable clinical information.
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Klingel, Reinhard, Andreas Heibges, and Cordula Fassbender. "Hypertriglyzeridämie mit Pankreatitis." Dialyse aktuell 25, no. 01 (February 2021): 38–44. http://dx.doi.org/10.1055/a-1303-8379.

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ZUSAMMENFASSUNGInsbesondere die schwere Hypertriglyzeridämie (SHTG) führt zu einem erhöhten Risiko für eine besonders schwer verlaufende Pankreatitis. In der Akutsituation einer SHTG-Pankreatitis müssen die Triglyzeride sehr rasch gesenkt werden, um einen weiteren Organschaden zu verhindern. Mithilfe der therapeutischen Apherese in Form des Plasmaaustausches oder der Doppelfiltrations-Plasmapherese (DFPP) gelingt dies effektiv und sicher. Für Patienten mit rezidivierender SHTG-Pankreatitis kann eine Langzeittherapie mit Apherese zusätzlich zu Diät, Lebensstilmaßnahmen und medikamentöser Therapie ein wichtiges Therapiemodul zur Prävention erneuter Ereignisse sein. In der Schwangerschaft ist jede zweite Pankreatitis durch zu hohe Triglyzeride verursacht. Bei fortbestehender Fettstoffwechselstörung kann die therapeutische Apherese eine Therapieoption sein, um ein solches für den Fötus und die Mutter lebensbedrohliches Ereignis zu verhindern.
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Hauenschild, A., H. Schnell-Kretschmer, and H. U. Klör. "Severe hypertriglyceridemia (SHTG) and atherosclerosis." Atherosclerosis 144 (May 1999): 135–36. http://dx.doi.org/10.1016/s0021-9150(99)80529-2.

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Hauenschild, A., H. Schnell-Kretschmer, and H. U. Kloer. "Severe hypertriglyceridemia (SHTG) and atherosclerosis." Atherosclerosis 151, no. 1 (July 2000): 177. http://dx.doi.org/10.1016/s0021-9150(00)80803-5.

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Kandulu, Jess, Ed Clifton, Iain Robertson, Neil Smart, and Karen Macpherson. "OP303 Do You Get The Message? Making HTA Findings Easier For Decision-Makers To Implement." International Journal of Technology Assessment in Health Care 37, S1 (December 2021): 11. http://dx.doi.org/10.1017/s026646232100091x.

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IntroductionOften health technology assessment (HTA) products developed by the Scottish Health Technologies Group (SHTG) did not reach clear directive conclusions because the evidence base for a technology was weak. Despite being methodologically robust, these products did not meet the needs of decision-makers and may have had negligible impact.MethodsSHTG set out to equip and empower the recommendation-making council (that is, appraisal committee) to reach clear conclusions. SHTG broadened the HTA components and types of evidence that could be considered. The increased breadth of evidence included: clinicians attending council meetings to respond to questions; patient groups making submissions and presenting at council meetings; Scotland-specific economic modelling; and consultation on draft recommendations. SHTG also restructured the council for improved deliberative decision-making.ResultsClear directive conclusions were reached in a substantially higher proportion of HTA products (eighty-eight percent in 2019 compared with eight percent in 2017). It became possible for decision-makers to implement findings. It also became feasible to assess the impact and implementation of recommendations.ConclusionsBroadening SHTG's consideration of HTA components has led to a clearer conclusion being reached and stronger messaging for decision makers. This positions SHTG to increase its influence in the use of health technologies in Scotland.
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Tu, Yung-Chun, Shui-Jinn Wang, Tseng-Hsing Lin, Chien-Hsiung Hung, Tsung-Che Tsai, Ru-Wen Wu, Kai-Ming Uang, and Tron-Min Chen. "Hydrothermal Growth of Quasi-Monocrystal ZnO Thin Films and Their Application in Ultraviolet Photodetectors." International Journal of Photoenergy 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/261372.

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Quasi-monocrystal ZnO film grown using the hydrothermal growth method is used for the fabrication of Cu2O/ZnO heterojunction (HJ) ultraviolet photodetectors (UV-PDs). The HJ was formed via the sputtering deposition of p-type Cu2O onto hydrothermally grown ZnO film (HTG-ZnO-film). The effect of annealing temperature in the nitrogen ambient on the photoluminescence spectra of the synthesized ZnO film was studied. The optoelectronic properties of Cu2O/ZnO film with various Cu2O thicknesses (250–750 nm) under UV light (365 nm; intensity: 3 mW/cm2) were determined. The UV sensitivity of the HTG-ZnO-film-based UV-PDs and the sputtered ZnO-film-based UV-PDs were 55.6-fold (SHTG) and 8.8-fold (Ssputter), respectively. The significant gain in sensitivity (SHTG/Ssputter= 630%) of the proposed ZnO-film-based device compared to that for the device based on sputtered film can be attributed to the improved photoelectric properties of quasi-monocrystal ZnO film.
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Macpherson, Karen, Lorna Thompson, and Susan Myles. "VP197 Sustainable Production Of Rapid Health Technology Assessments And Clinical Guidelines." International Journal of Technology Assessment in Health Care 33, S1 (2017): 241–42. http://dx.doi.org/10.1017/s026646231700424x.

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INTRODUCTION:With increasing resource pressures on health systems, rapid developments in innovative technologies and limited numbers of skilled assessors, there is a need to establish sustainable methods to provide advice on healthcare technologies for decision makers. The European Network for Health Technology Assessment (EUnetHTA) has been testing an approach of collaborative production of rapid Health Technology Assessments (HTAs) and adaptation of these locally. The Scottish Health Technologies Group (SHTG) participated in two collaborative and adaptation projects to test whether this could save time and resource, whilst providing a product as robust and relevant as if developed locally. Concurrently the Scottish Intercollegiate Guidelines Network (SIGN) has been exploring ways to develop clinical guidelines more efficiently, including the use of rapid HTAs to inform recommendations.METHODS:Having established the relevance of the topics to NHS Scotland, SHTG participated as peer reviewers for EUnetHTA reviews on mitral valve repair and mechanical thrombectomy. On completion, SHTG summarized their content to fit with the well-accepted rapid review report format used in Scotland. Content was supplemented with a review of economic evidence, currently not included in the European reports, local epidemiological information and recently published studies. The thrombectomy report and associated Advice Statement were used by a small expert group to update a SIGN clinical guideline recommendation.RESULTS:Providing advice through adaptation proved feasible and acceptable to stakeholders. Limited time was saved because of the supplementary work undertaken, and lessons have been learned about what should and should not be done in future .The guideline recommendation was updated and made available more quickly than similar previous updates.CONCLUSIONS:Further such collaborations and adaptations will be pursued as this appears to be a sustainable approach for the future. The process could be aided by EUnetHTA publishing forward work plans and also by the inclusion of economic information, with details of the decision-making context provided, to allow assessment of its relevance locally.
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Dissertations / Theses on the topic "SHTG"

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Sanchez, Washington. "Modulation of the SHBG signalling axis." Queensland University of Technology, 2009. http://eprints.qut.edu.au/28604/.

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Sex hormone-binding globulin (SHBG) is a homodimeric plasma glycoprotein that is the major sex steroid carrier-protein in the bloodstream and functions also as a key regulator of steroid bioavailability within target tissues, such as the prostate. Additionally, SHBG binds to prostatic cell membranes via the putative and unidentified SHBG receptor (RSHBG), activating a signal transduction pathway implicated in stimulating both proliferation and expression of prostate specific antigen (PSA) in prostate cell lines in vitro. A yeast-two hybrid assay suggested an interaction between SHBG and kallikrein-related protease (KLK) 4, which is a serine protease implicated in the progression of prostate cancer. The potential interaction between these two proteins was investigated in this PhD thesis to determine whether SHBG is a proteolytic substrate of KLK4 and other members of the KLK family including KLK3/PSA, KLK7 and KLK14. Furthermore, the effects from SHBG proteolytic degradation on SHBG-regulated steroid bioavailability and the activation of the putative RSHBG signal transduction pathway were examined in the LNCaP prostate cancer cell line. SHBG was found to be a proteolytic substrate of the trypsin-like KLK4 and KLK14 in vitro, yielding several proteolysis fragments. Both chymotrypsin-like PSA and KLK7 displayed insignificant proteolytic activity against SHBG. The kinetic parameters of SHBG proteolysis by KLK4 and KLK14 demonstrate a strong enzyme-substrate binding capacity, possessing a Km of 1.2 ± 0.7 µM and 2.1 ± 0.6 µM respectively. The catalytic efficiencies (kcat/Km) of KLK4 and KLK14 proteolysis of SHBG were 1.6 x 104 M-1s-1 and 3.8 x 104 M-1s-1 respectively, which were comparable to parameters previously reported for peptide substrates. N-terminal sequencing of the fragments revealed cleavage near the junction of the N- and C-terminal laminin globulin-like (G-like) domains of SHBG, resulting in the division of the two globulins and ultimately the full degradation of these fragments by KLK4 and KLK14 over time. Proteolytic fragments that may retain steroid binding were rapidly degraded by both proteases, while fragments containing residues beyond the steroid binding pocket were less degraded over the same period of time. Degradation of SHBG was inhibited by the divalent metal cations calcium and zinc for KLK4, and calcium, zinc and magnesium for KLK14. The human secreted serine protease inhibitors (serpins), α1-antitrypsin and α2-antiplasmin, inhibited KLK4 and KLK14 proteolysis of SHBG; α1-antichymotrypsin inhibited KLK4 but not KLK14 activity. The inhibition by these serpins was comparable and in some cases more effective than general trypsin protease inhibitors such as aprotinin and phenylmethanesulfonyl fluoride (PMSF). The binding of 5α-dihydrotestosterone (DHT) to SHBG modulated interactions with KLK4 and KLK14. Steroid-free SHBG was more readily digested by both enzymes than DHT-bound SHBG. Moreover, a binding interaction exists between SHBG and pro-KLK4 and pro-KLK14, with DHT strengthening the binding to pro-KLK4 only. The inhibition of androgen uptake by cultured prostate cancer cells, mediated by SHBG steroid-binding, was examined to assess whether SHBG proteolysis by KLK4 and KLK14 modulated this process. Proteolytic digestion eliminated the ability of SHBG to inhibit the uptake of DHT from conditioned media into LNCaP cells. Therefore, the proteolysis of SHBG by KLK4 and KLK14 increased steroid bioavailability in vitro, leading to an increased uptake of androgens by prostate cancer cells. Interestingly, different transcriptional responses of PSA and KLK2, which are androgen-regulated genes, to DHT-bounsd SHBG treatment were observed between low and high passage number LNCaP cells (lpLNCaP and hpLNCaP respectively). HpLNCaP cells treated with DHT-bound SHBG demonstrated a significant synergistic upregulation of PSA and KLK2 above DHT or SHBG treatment alone, which is similar to previously reported downstream responses from RSHBG-mediated signaling activation. As this result was not seen in lpLNCaP cells, only hpLNCaP cells were further investigated to examine the modulation of potential RSHBG activity by KLK4 and KLK14 proteolysis of SHBG. Contrary to reported results, no increase in intracellular cAMP was observed in hpLNCaP cells when treated with SHBG in the presence and absence of either DHT or estradiol. As a result, the modulation of RSHBG-mediated signaling activation could not be determined. Finally, the identification of the RSHBG from both breast (MCF-7) and prostate cancer (LNCaP) cell lines was attempted. Fluorescently labeled peptides corresponding to the putative receptor binding domain (RBD) of SHBG were shown to be internalized by MCF-7 cells. Crosslinking of the RBD peptide to the cell surfaces of both MCF-7 and LNCaP cells, demonstrated the interaction of the peptide with several targets. These targets were then captured using RBD peptides synthesized onto a hydrophilic scaffold and analysed by mass spectrometry. The samples captured by the RBD peptide returned statistically significantly matches for cytokeratin 8, 18 and 19 as well as microtubule-actin crosslinking factor 1, which may indicate a novel interaction between SHBG and these proteins, but ultimately failed to detect a membrane receptor potentially responsible for the putative RSHBG-mediated signaling. This PhD project has reported the proteolytic processing of SHBG by two members of the kallikrein family, KLK4 and KLK14. The effect of SHBG proteolysis by KLK4 and KLK14 on RSHBG-mediated signaling activation was unable to be determined as the reported signal transduction pathway was not activated after treatment with SHBG, in combination with either DHT or estradiol. However, the digestion of SHBG by these two proteases positively regulated androgen bioavailability to prostate cancer cells in vitro. The increased uptake of androgens is deleterious in prostate cancer due to the promotion of proliferation, metastasis, invasion and the inhibition of apoptosis. The increased bioavailability of androgens, from SHBG proteolysis by KLK4 and KLK14, may therefore promote both carcinogenesis and progression of prostate cancer. Finally, this information may contribute to the development of therapeutic treatment strategies for prostate cancer by inhibiting the proteolysis of SHBG, by KLK4 and KLK14, to prevent the increased uptake of androgens by hormone-dependent cancerous tissues.
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2

Sanchez, Washington Yamanda. "Modulation of the SHBG signalling axis." Thesis, Queensland University of Technology, 2009. https://eprints.qut.edu.au/28604/2/Washington_Sanchez_Thesis.pdf.

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Sex hormone-binding globulin (SHBG) is a homodimeric plasma glycoprotein that is the major sex steroid carrier-protein in the bloodstream and functions also as a key regulator of steroid bioavailability within target tissues, such as the prostate. Additionally, SHBG binds to prostatic cell membranes via the putative and unidentified SHBG receptor (RSHBG), activating a signal transduction pathway implicated in stimulating both proliferation and expression of prostate specific antigen (PSA) in prostate cell lines in vitro. A yeast-two hybrid assay suggested an interaction between SHBG and kallikrein-related protease (KLK) 4, which is a serine protease implicated in the progression of prostate cancer. The potential interaction between these two proteins was investigated in this PhD thesis to determine whether SHBG is a proteolytic substrate of KLK4 and other members of the KLK family including KLK3/PSA, KLK7 and KLK14. Furthermore, the effects from SHBG proteolytic degradation on SHBG-regulated steroid bioavailability and the activation of the putative RSHBG signal transduction pathway were examined in the LNCaP prostate cancer cell line. SHBG was found to be a proteolytic substrate of the trypsin-like KLK4 and KLK14 in vitro, yielding several proteolysis fragments. Both chymotrypsin-like PSA and KLK7 displayed insignificant proteolytic activity against SHBG. The kinetic parameters of SHBG proteolysis by KLK4 and KLK14 demonstrate a strong enzyme-substrate binding capacity, possessing a Km of 1.2 ± 0.7 µM and 2.1 ± 0.6 µM respectively. The catalytic efficiencies (kcat/Km) of KLK4 and KLK14 proteolysis of SHBG were 1.6 x 104 M-1s-1 and 3.8 x 104 M-1s-1 respectively, which were comparable to parameters previously reported for peptide substrates. N-terminal sequencing of the fragments revealed cleavage near the junction of the N- and C-terminal laminin globulin-like (G-like) domains of SHBG, resulting in the division of the two globulins and ultimately the full degradation of these fragments by KLK4 and KLK14 over time. Proteolytic fragments that may retain steroid binding were rapidly degraded by both proteases, while fragments containing residues beyond the steroid binding pocket were less degraded over the same period of time. Degradation of SHBG was inhibited by the divalent metal cations calcium and zinc for KLK4, and calcium, zinc and magnesium for KLK14. The human secreted serine protease inhibitors (serpins), α1-antitrypsin and α2-antiplasmin, inhibited KLK4 and KLK14 proteolysis of SHBG; α1-antichymotrypsin inhibited KLK4 but not KLK14 activity. The inhibition by these serpins was comparable and in some cases more effective than general trypsin protease inhibitors such as aprotinin and phenylmethanesulfonyl fluoride (PMSF). The binding of 5α-dihydrotestosterone (DHT) to SHBG modulated interactions with KLK4 and KLK14. Steroid-free SHBG was more readily digested by both enzymes than DHT-bound SHBG. Moreover, a binding interaction exists between SHBG and pro-KLK4 and pro-KLK14, with DHT strengthening the binding to pro-KLK4 only. The inhibition of androgen uptake by cultured prostate cancer cells, mediated by SHBG steroid-binding, was examined to assess whether SHBG proteolysis by KLK4 and KLK14 modulated this process. Proteolytic digestion eliminated the ability of SHBG to inhibit the uptake of DHT from conditioned media into LNCaP cells. Therefore, the proteolysis of SHBG by KLK4 and KLK14 increased steroid bioavailability in vitro, leading to an increased uptake of androgens by prostate cancer cells. Interestingly, different transcriptional responses of PSA and KLK2, which are androgen-regulated genes, to DHT-bounsd SHBG treatment were observed between low and high passage number LNCaP cells (lpLNCaP and hpLNCaP respectively). HpLNCaP cells treated with DHT-bound SHBG demonstrated a significant synergistic upregulation of PSA and KLK2 above DHT or SHBG treatment alone, which is similar to previously reported downstream responses from RSHBG-mediated signaling activation. As this result was not seen in lpLNCaP cells, only hpLNCaP cells were further investigated to examine the modulation of potential RSHBG activity by KLK4 and KLK14 proteolysis of SHBG. Contrary to reported results, no increase in intracellular cAMP was observed in hpLNCaP cells when treated with SHBG in the presence and absence of either DHT or estradiol. As a result, the modulation of RSHBG-mediated signaling activation could not be determined. Finally, the identification of the RSHBG from both breast (MCF-7) and prostate cancer (LNCaP) cell lines was attempted. Fluorescently labeled peptides corresponding to the putative receptor binding domain (RBD) of SHBG were shown to be internalized by MCF-7 cells. Crosslinking of the RBD peptide to the cell surfaces of both MCF-7 and LNCaP cells, demonstrated the interaction of the peptide with several targets. These targets were then captured using RBD peptides synthesized onto a hydrophilic scaffold and analysed by mass spectrometry. The samples captured by the RBD peptide returned statistically significantly matches for cytokeratin 8, 18 and 19 as well as microtubule-actin crosslinking factor 1, which may indicate a novel interaction between SHBG and these proteins, but ultimately failed to detect a membrane receptor potentially responsible for the putative RSHBG-mediated signaling. This PhD project has reported the proteolytic processing of SHBG by two members of the kallikrein family, KLK4 and KLK14. The effect of SHBG proteolysis by KLK4 and KLK14 on RSHBG-mediated signaling activation was unable to be determined as the reported signal transduction pathway was not activated after treatment with SHBG, in combination with either DHT or estradiol. However, the digestion of SHBG by these two proteases positively regulated androgen bioavailability to prostate cancer cells in vitro. The increased uptake of androgens is deleterious in prostate cancer due to the promotion of proliferation, metastasis, invasion and the inhibition of apoptosis. The increased bioavailability of androgens, from SHBG proteolysis by KLK4 and KLK14, may therefore promote both carcinogenesis and progression of prostate cancer. Finally, this information may contribute to the development of therapeutic treatment strategies for prostate cancer by inhibiting the proteolysis of SHBG, by KLK4 and KLK14, to prevent the increased uptake of androgens by hormone-dependent cancerous tissues.
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3

Grishkovskaya, Irina. "Kristallographische Studie zum Sexualhormon-bindenden Globulin (SHBG)." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/66/index.html.

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DUMOULIN, SYLVIE. "Effet des hormones thyroidiennes sur les glycoproteines de transport des steroides, shbg et cbg sur le rapport gbg/shbg." Toulouse 3, 1993. http://www.theses.fr/1993TOU31535.

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Aebiacher, Nicholas J. "Aspects of the biology of the shag (Palacrocorax aristotelis)." Thesis, Durham University, 1985. http://etheses.dur.ac.uk/7880/.

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On the Isle of May, Scotland, large numbers of Shags have been marked annually since 1962. From 1981 to 1983, this marked population was sampled to investigate retrospectively a catastrophic decline in numbers of breeding Shags between 1974 and 1976. An electrolytic method was developed to read incomplete ring-numbers on abraded rings: it was 94% successful. The adult annual survival rate before, during and after the decline remained constant at 87%; during the decline, up to 60% of experienced adults refrained from breeding, laying was a month later than usual, chick production and post-fledging survival were both abnormally low. Failure of the fish stocks around the Isle of May probably caused the decline. Dispersal, pair-bond and reproductive performance with respect to age, timing of breeding and nest-site quality were also examined. Natal and breeding fidelity were strong, and more pronounced in males. Second-year males, breeding for the first time, performed half as well as older males; the effects of other male age categories and female age were unimportant. A strong age-independent seasonal decline in breeding performance was attributable to both environmental factors and individual quality. Four nest-site quality criteria affected reproduction: ledge size, dampness, exposure, and vulnerability to the sea. Experienced Shags bred early and occupied good sites; the social structure forced later-breeding recruits onto poorer sites within the breeding group. Shags which changed sites between years preferred those with a previous history of occupation. Sites occupied continuously were of highest quality. The study population currently shows no sign of density-dependent regulation; potential future regulatory factors are food and a shortage of good quality nest-sites.
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Hall, Margaret Emily. "Senescence and reproductive performance in the European shag (Phalacrocorax aristotelis)." Thesis, University of Glasgow, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404641.

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Jänne, Marja. "Regulation of human sex hormone-binding globulin gene (shbg) expression." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/janne/.

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King, Ruth. "Bayesian model discrimination in the analysis of capture-recapture and related data." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391229.

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Петровський, А. А., and І. О. Товкач. "Модуль захисту авторизації системи «ПОЛІДАР» на основі гібридного алгоритму W-SHAG." Thesis, Cумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/47084.

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Podeur, Vincent. "Modélisation expérimentale et numérique du power take-off d’un bassin houlomoteur." Electronic Thesis or Diss., Brest, École nationale supérieure de techniques avancées Bretagne, 2022. http://www.theses.fr/2022ENTA0005.

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Les travaux présentés portent sur l'étude du power take off d'un système houlomoteur. Celui-ci est constitué d'un ensemble de bassins connectés entre eux via des clapets souples assurant une circulation à sens unique. Les mouvements de la plate-forme sur laquelle le système est installé induisent un phénomène de ballottement du fluide présent dans ces bassins. Les vagues ainsi générées viennent alors alimenter une cuve cylindrique dont le fond est percé d'un orifice central. Le fluide injecté dans ce réservoir engendre un écoulement de type tourbillon de vidange, dont l’énergie cinétique est extraite par une turbine à axe vertical. La première phase de ces travaux se concentre sur l'étude expérimentale du tourbillon de vidange en écoulement stationnaire. L'évolution du champ de vitesse dans le bassin, avec et sans turbine, est étudié par particle image velocimetry (PIV). En parallèle, la puissance délivrée par la turbine et la hauteur d'eau dans le bassin sont mesurées. Ces résultats sont utilisés pour définir les hypothèses de départ pour la création d'un modèle numérique. La deuxième phase de ces travaux porte sur l'étude expérimentale du tourbillon de vidange en écoulement instationnaire. Un second dispositif de mesure est spécialement construit et instrumenté. Ce dernier permet de modéliser plus fidèlement l'écoulement rencontré dans le système houlomoteur. La méthode PIV est de nouveau utilisée. La dernière phase des travaux porte sur la modélisation numérique de la turbine à axe vertical. Le modèle développé se fonde sur la théorie des écoulements potentiels et prend en compte les effets 3D. Les résultats obtenus sont comparés aux résultats expérimentaux
The present work aims at studying the power take-off of a wave energy converter (WEC). This system is composed of a set of connected tanks. Rubber flaps are installed at tanks inlet and outlet to ensure a one-way flow direction. Thanks to wave induced motions of the supporting platform, sloshing appears inside the WEC tanks which feed a cylindrical basin with a centered drain hole at its bottom. Then, a bathtub vortex flow appears within this tank, where a vertical axis turbine is installed to harvest kinetic energy from the flow. The first phase of this research focuses on studying the steady bathtub flow. To do so, a dedicated experiment is built. Velocity field within the cylindrical basin, with and without the turbine, is studied via Particle Image Velocimetry (PIV). In addition, power production from the turbine and water level inside the tank are measured. These results are used to define starting hypothesis for developing a numerical model of the turbine. The second phase of this research focuses on studying the unsteady bathtub flow. For this purpose, a second experiment is built. This setup provides a more realistic environment, closer to what can be observed with the WEC system. PIV measurements are also used extensively to study the flow with and without the turbine. The last stage of this research focuses on the numerical modelling of the vertical axis turbine. The model is based on the potential flow theory. First, a two-dimensional approach is used to validate the early pieces of the model. Secondly, a three-dimensional approach is adopted to account for more complex flow features. Finally, numerical and experiment results are compared
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Books on the topic "SHTG"

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Tumanova, Alla. Shag vpravo, shag vlevo--. Moskva: Progress, 1995.

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Gromov, Aleksandr. Shag vlevo, shag vpravo. Moskva: Izd-vo AST, 1999.

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Han, Jenny. Shug. New York: Simon & Schuster Books for Young Readers, 2006.

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Han, Jenny. Shug. London: Simon & Schuster, 2006.

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McClung, Robert M. Shag. Hamden, Conn: Linnet Books, 1991.

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Ishtavkhaĭ, N. Khonot͡s︡: Shog naĭruulal, shog khoshin ȯgu̇u̇lėgu̇u̇d. Ulaanbaatar: Mongolyn Sėtgu̇u̇lchdiĭn Kholboo, 1985.

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Ḥayātʼi shāg. Kīc: Astīn Shangkār, 2015.

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Smirnova, Natasha. Shag navstrechu. Moskva: Muraveĭ, 2002.

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Akengin, Yahya. Shteg dashurie. Shkup: Fine-Art, 2005.

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Akengin, Yahya. Shteg dashurie. Shkup: Fine-Art, 2005.

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Book chapters on the topic "SHTG"

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Gooch, Jan W. "Shag Carpet." In Encyclopedic Dictionary of Polymers, 656. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_10513.

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Sinha, Frances, Ajay Tankha, K. Raja Reddy, and Malcolm Harper. "SHG Members." In Microfinance Self-Help Groups in India, 25–32. Rugby, Warwickshire, United Kingdom: Practical Action Publishing, 2009. http://dx.doi.org/10.3362/9781780440293.003.

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Harrison, Ken M. "SHG Processing Software." In The Patrick Moore Practical Astronomy Series, 145–70. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-24874-5_8.

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Piek, Jürgen. "31. Schädelhirntrauma (SHT)." In Neurochirurgie für Einsteiger, edited by Jürgen Piek, 221–54. Berlin, Boston: De Gruyter, 2019. http://dx.doi.org/10.1515/9783110611304-031.

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Harrison, Ken M. "Amateur Digital SHG Instruments." In The Patrick Moore Practical Astronomy Series, 171–217. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-24874-5_9.

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Niemeyer, P. "Bedeutung von Selbsthilfegruppen (SHG)." In Angeborene Stoffwechselkrankheiten bei Erwachsenen, 65–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-45188-1_7.

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Micoli, M. Di. "Schädel-Hirn-Trauma (SHT)." In Taktische Medizin, 249–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-20697-9_14.

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Mayer, C., and W. Siems. "Schädel-Hirn-Trauma (SHT)." In 100 Krankheitsbilder in der Physiotherapie, 176–95. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-17267-0_18.

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Di Micoli, M. "Schädel-Hirn-Trauma (SHT)." In Taktische Medizin, 309–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-39689-2_18.

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Mehlhorn, Heinz. "Soil-Transmitted Helminths (SHT)." In Encyclopedia of Parasitology, 2530. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_4334.

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Conference papers on the topic "SHTG"

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Chen, Yufei, Weiwei Sun, and Xiaojun Wan. "Accurate SHRG-Based Semantic Parsing." In Proceedings of the 56th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). Stroudsburg, PA, USA: Association for Computational Linguistics, 2018. http://dx.doi.org/10.18653/v1/p18-1038.

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Kim, Jong Man, Byung S. Choi, Yoon S. Choi, Sun I. Kim, Jong-Min Kim, Hans I. Bjelkhagen, and Nicholas J. Phillips. "Transmission and reflection SHSG holograms." In Photonics West 2001 - Electronic Imaging, edited by Stephen A. Benton, Sylvia H. Stevenson, and T. John Trout. SPIE, 2001. http://dx.doi.org/10.1117/12.429461.

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Campagnola, Paul J., Molly A. Brewer, Karissa Tilbury, Visar Ajeti, Kevin E. Eliceiri, Patricia J. Keely, and Manish Patankar. "SHG imaging of Cancer." In Biomedical Optics. Washington, D.C.: OSA, 2012. http://dx.doi.org/10.1364/biomed.2012.bsu4b.1.

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Kitaoka, Yasuo, Kiminori Mizuuchi, Kazuhisa Yamamoto, Makoto Kato, Wang Long Zhou, and Takatomo Sasaki. "Compact SHG green lasers." In Photonics West '96, edited by Kurt J. Linden and Prasad R. Akkapeddi. SPIE, 1996. http://dx.doi.org/10.1117/12.237673.

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Tatsuno, K., K. Ito, S. Helmfrid, and S. Makio. "Waveguide QPM-SHG-Modulator." In Compact Blue-Green Lasers. Washington, D.C.: Optica Publishing Group, 1994. http://dx.doi.org/10.1364/cbgl.1994.cthb.4.

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A Novel intensity modulator for second harmonic waveguide laser is demonstrated. Noise caused by spectrum broadening in a diode-laser direct-modulation schem is avoided by using the electro-optic effect to modulate the phase mismatch in the frequency-doubling process.
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Soos, J. I., X. L. Wang, Y. G. Liu, J. R. Han, B. Xu, and M. H. Jiang. "Novel acoustooptic SHG modulator." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1991. http://dx.doi.org/10.1364/oam.1991.fv7.

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We have demonstrated, the first to our knowledge, acoustooptic second-harmonic generation (AOSHG) modulator. A LiNbO3 longitudinal piezoelectric transducer was bounded in a 1.06–0.53-µm KTP* SHG crystal. The modulator is operated at 100 MHz and with 50 MHz bandwidth. The modulation of green light has been achieved.
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Andreev, Yury M., Valery A. Svetlichnyi, Alexander Tanichev, Konstantin A. Kokh, Artem B. Kuznetsov, Gregory V. Lanskii, and Dmitry Ezhov. "SHG in γ-Ga2S3 powder." In XIII International Conference on Atomic and Molecular Pulsed Lasers, edited by Andrei M. Kabanov and Victor F. Tarasenko. SPIE, 2018. http://dx.doi.org/10.1117/12.2303581.

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Durécu, A., G. Canat, J. Le Gouët, L. Lombard, and P. Bourdon. "Coherent combining of SHG converters." In CLEO: Applications and Technology. Washington, D.C.: OSA, 2014. http://dx.doi.org/10.1364/cleo_at.2014.jth2a.19.

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Masuda, Hisashi, Fumisada Maeda, Michio Oka, Yushi Kaneda, Minako Sugiura, and Shigeo Kubota. "Miniature integrated SHG green laser." In Compact Blue-Green Lasers. Washington, D.C.: Optica Publishing Group, 1992. http://dx.doi.org/10.1364/cbgl.1992.fa3.

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Diode-pumped intracavity frequency doubled Nd:YAG lasers have been intensively investigated. Low noise characteristics of such a laser as well as its shorter wavelength than conventional laser diodes are attractive features for the higher density optical disk applications.1
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Vinevskij, E. I., E. E. Ul'yanchenko, O. V. Troshchij, and A. A. Polonenko. "Mechanized technology for harvesting tobacco seeds and shag." In General question of world science. "Science of Russia", 2019. http://dx.doi.org/10.18411/gq-31-07-2019-15.

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Reports on the topic "SHTG"

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Bannochie, C. J. Results Hg speciation testing on tank 21 and solvent hold tank (SHT) material. Office of Scientific and Technical Information (OSTI), September 2015. http://dx.doi.org/10.2172/1215493.

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Bannochie, C. J. Results of Preliminary Hg Speciation Testing on Tank 21 and Solvent Hold Tank (SHT) Material. Office of Scientific and Technical Information (OSTI), April 2015. http://dx.doi.org/10.2172/1178651.

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Bannochie, C. Results of Hg speciation testing on 3Q15 tank 50, salt solution feed tank (SSFT), and solvent hold tank (SHT) materials. Office of Scientific and Technical Information (OSTI), August 2015. http://dx.doi.org/10.2172/1212656.

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