To see the other types of publications on this topic, follow the link: Sherpa.

Journal articles on the topic 'Sherpa'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Sherpa.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Droma, Yunden, Masayuki Hanaoka, Takumi Kinjo, Nobumitsu Kobayashi, Masanori Yasuo, Yoshiaki Kitaguchi, and Masao Ota. "The blunted vascular endothelial growth factor-A (VEGF-A) response to high-altitude hypoxia and genetic variants in the promoter region of the VEGFA gene in Sherpa highlanders." PeerJ 10 (August 17, 2022): e13893. http://dx.doi.org/10.7717/peerj.13893.

Full text
Abstract:
Background Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitudes, which may be achieved by mechanisms promoting microcirculatory blood flow and capillary density at high altitudes for restoring oxygen supply to tissues. Vascular endothelial growth factors (VEGFs) are important signaling proteins involved in vasculogenesis and angiogenesis which are stimulated by hypoxia. We hypothesize that the VEGF-A, the major member of the VEGF family, and the gene encoding VEGF-A (VEGFA) play a part in the adaptation to high-altitude hypoxia in Sherpa highlanders. Methods Fifty-one Sherpa highlanders in Namche Bazaar village at a high altitude of 3,440 meters (m) above sea level and 76 non-Sherpa lowlanders in Kathmandu city at 1,300 m in Nepal were recruited for the study. Venous blood was sampled to obtain plasma and extract DNA from each subject. The plasma VEGF-A concentrations were measured and five single-nucleotide polymorphisms (SNPs, rs699947, rs833061, rs1570360, rs2010963, and rs3025039) in the VEGFA were genotyped. The VEGF-A levels and allelic frequencies of the SNPs were compared between the two populations. Results A significant difference in oxygen saturation (SpO2) was observed between the two ethnic groups locating at different elevations (93.7 ± 0.2% in Sherpas at 3,440 m vs. 96.7 ± 0.2% in non-Sherpas at 1,300 m, P < 0.05). The plasma VEGF-A concentration in the Sherpas at high altitude was on the same level as that in the non-Sherpas at low altitude (262.8 ± 17.9 pg/ml vs. 266.8 ± 21.8 pg/ml, P = 0.88). This result suggested that the plasma VEGF-A concentration in Sherpa highlanders was stable despite a high-altitude hypoxic stimulus and that therefore the Sherpas exhibited a phenotype of blunted response to hypoxic stress. Moreover, the allele frequencies of the SNPs rs699947, rs833061, and rs2010963 in the promoter region of the VEGFA were different between the Sherpa highlanders and non-Sherpa lowlanders (corrected P values = 3.30 ×10−5, 4.95 ×10−4, and 1.19 ×10−7, respectively). Conclusions Sherpa highlanders exhibited a blunted VEGF-A response to hypoxia at high altitudes, which was speculated to be associated with the distinctive genetic variations of the SNPs and haplotype in the promoter region of VEGFA in Sherpa highlanders.
APA, Harvard, Vancouver, ISO, and other styles
2

Rahman, Mustafizur, and Prof S. Ganesh Baskaran. "CONSONANTAL SYSTEM OF SHERPA." Journal of English Language and Literature 09, no. 01 (2022): 01–10. http://dx.doi.org/10.54513/joell.2022.9101.

Full text
Abstract:
The present study “Consonantal system of Sherpa” discusses the Sherpas of Sikkim mainly settled in South and West District. According to the Census of India 2001, the total speaker of Sherpa in Sikkim is 13,922. However, Denzong Sherpa Association claims that the population of Sherpa is more than 65,000 out of which more than 32,000 people speak their Mother Tongue in their native environment particularly in the home domain. Linguistically, Robert Shafer has divided Tibeto-Burman into four main groups: Bodic, Baric, Burmic and Karenic. According to Shafer, Sherpa belongs to the Central Unit of the Bodish Section within the Bodic Sub-division of Sino-Tibetan. The present paper attempts to describe the Consonantal system of Sherpa. Sherpa has twenty six (26) consonantal sounds. It has fourteen stops i.e., /p, pʰ, b, t, tʰ, d, ʈ, ʈʰ, ɖ, c, cʰ, k, kʰ, ɡ/, four nasals /m, n, ɲ, ŋ/, four fricatives /s, ʃ, ʒ, h/ one lateral /l/one trill /r/ and two semi-vowels; bilabial semi-vowel /w/ and palatal semi-vowel /j/. Consonant combination in Sherpa can be classified into two categories these are: (i) consonant cluster (ii) consonant sequence. Sherpa has initial and medial consonant clusters that occur within the syllabic boundary. Sherpa has a wide variety of consonant sequences. Gemination, Homorganic and Contagious are the Consonant sequences found in Sherpa Language.
APA, Harvard, Vancouver, ISO, and other styles
3

Gautam, Bhim Lal. "Language Use and Attitude among the Sherpa Speaking Community in the Kathmandu Valley." Gipan 3, no. 2 (November 1, 2017): 26–37. http://dx.doi.org/10.3126/gipan.v3i2.48897.

Full text
Abstract:
This paper aims to explore the status of language use and attitude among the Sherpa speaking community in the Kathmandu valley, the multilingual capital city of Nepal. It focuses on language contact situations in different domains viz. social, cultural, personal, and official as well as media related activities where the Sherpas make use of different languages along with the use of their own mother tongue. Based on 45 questionnaires from different informants, this paper presents interesting patterns of language use and attitudes among the Sherpa speaking community in Kathmandu.
APA, Harvard, Vancouver, ISO, and other styles
4

Curry, Carolann Lee. "SHERPA Services and SHERPA/RoMEO." Journal of Electronic Resources in Medical Libraries 14, no. 3-4 (September 26, 2017): 135–38. http://dx.doi.org/10.1080/15424065.2017.1368424.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Simpson, Todd. "SHERPA/RoMEO." Charleston Advisor 18, no. 1 (July 1, 2016): 31–35. http://dx.doi.org/10.5260/chara.18.1.31.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Moyle, Martin, Rebecca Stockley, and Suzanne Tonkin. "SHERPA‐LEAP." OCLC Systems & Services: International digital library perspectives 23, no. 2 (June 5, 2007): 125–32. http://dx.doi.org/10.1108/10650750710748423.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Gilbert-Kawai, Edward, Jonny Coppel, Jo Court, Jildou van der Kaaij, Andre Vercueil, Martin Feelisch, Denny Levett, Monty Mythen, Michael P. Grocott, and Daniel Martin. "Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude." Journal of Applied Physiology 122, no. 4 (April 1, 2017): 1011–18. http://dx.doi.org/10.1152/japplphysiol.00970.2016.

Full text
Abstract:
Anecdotal reports suggest that Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitude, despite exhibiting lower arterial oxygen content than acclimatized lowlanders. This study tested the hypothesis that Sherpas exposed to hypobaric hypoxia on ascent to 5,300 m develop increased microcirculatory blood flow as a means of maintaining tissue oxygen delivery. Incident dark-field imaging was used to obtain images of the sublingual microcirculation from 64 Sherpas and 69 lowlanders. Serial measurements were obtained from participants undertaking an ascent from baseline testing (35 m or 1,300 m) to Everest base camp (5,300 m) and following subsequent descent in Kathmandu (1,300 m). Microcirculatory flow index and heterogeneity index were used to provide indexes of microcirculatory flow, while capillary density was assessed using small vessel density. Sherpas demonstrated significantly greater microcirculatory blood flow at Everest base camp, but not at baseline testing or on return in Kathmandu, than lowlanders. Additionally, blood flow exhibited greater homogeneity at 5,300 and 1,300 m (descent) in Sherpas than lowlanders. Sublingual small vessel density was not different between the two cohorts at baseline testing or at 1,300 m; however, at 5,300 m, capillary density was up to 30% greater in Sherpas. These data suggest that Sherpas can maintain a significantly greater microcirculatory flow per unit time and flow per unit volume of tissue at high altitude than lowlanders. These findings support the notion that peripheral vascular factors at the microcirculatory level may be important in the process of adaptation to hypoxia. NEW & NOTEWORTHY Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitude, yet the physiological mechanisms underlying this tolerance remain unknown. In our prospective study, conducted on healthy volunteers ascending to Everest base camp (5,300 m), we demonstrated that Sherpas have a higher sublingual microcirculatory blood flow and greater capillary density at high altitude than lowlanders. These findings support the notion that the peripheral microcirculation plays a key role in the process of long-term adaptation to hypoxia.
APA, Harvard, Vancouver, ISO, and other styles
8

Kim, Park Sa, and Hwan-Jin Song. "Usefulness of Automatic Hyperparameter Optimization in Developing Radiation Emulator in a Numerical Weather Prediction Model." Atmosphere 13, no. 5 (April 30, 2022): 721. http://dx.doi.org/10.3390/atmos13050721.

Full text
Abstract:
To improve the forecasting accuracy of a radiation emulator in a weather prediction model over the Korean peninsula, the learning rate used in neural network training was automatically optimized using the Sherpa. The Sherpa experiment results were compared with two control simulation results using learning rates of 0.0001 and 1 for different batch sizes (full to 500). In the offline evaluation, the Sherpa results showed significant improvements in predicting longwave/shortwave heating rates and fluxes compared to the lowest learning rate results, whereas the improvements compared to the highest learning rate were relatively small because the optimized values by the Sherpa were 0.4756–0.6656. The online evaluation results over one month, which were linked with the weather prediction model, demonstrated the usefulness of Sherpa on a universal performance for the radiation emulator. In particular, at the full batch size, Sherpa contributed to reducing the one-week forecast errors for longwave/shortwave fluxes, skin temperature, and precipitation by 39–125%, 137–159%, and 24–26%, respectively, compared with the two control simulations. Considering the widespread use of parallel learning based on full batch, Sherpa can contribute to producing robust results regardless of batch sizes used in neural network training for developing radiation emulators.
APA, Harvard, Vancouver, ISO, and other styles
9

Cloosterman, Sonja, Inez Wijnands, Simone Huygens, Valérie Wester, Ka-Hoo Lam, Eva Strijbis, Bram den Teuling, and Matthijs Versteegh. "The Potential Impact of Digital Biomarkers in Multiple Sclerosis in The Netherlands: An Early Health Technology Assessment of MS Sherpa." Brain Sciences 11, no. 10 (September 30, 2021): 1305. http://dx.doi.org/10.3390/brainsci11101305.

Full text
Abstract:
(1) Background: Monitoring of Multiple Sclerosis (MS) with eHealth interventions or digital biomarkers provides added value to the current care path. Evidence in the literature is currently scarce. MS sherpa is an eHealth intervention with digital biomarkers, aimed at monitoring symptom progression and disease activity. To show the added value of digital biomarker–based eHealth interventions to the MS care path, an early Health Technology Assessment (eHTA) was performed, with MS sherpa as an example, to assess the potential impact on treatment switches. (2) Methods: The eHTA was performed according to the Dutch guidelines for health economic evaluations. A decision analytic MS model was used to estimate the costs and benefits of MS standard care with and without use of MS sherpa, expressed in incremental cost-effectiveness ratios (ICERs) from both societal and health care perspectives. The efficacy of MS sherpa on early detection of active disease and the initiation of a treatment switch were modeled for a range of assumed efficacy (5%, 10%, 15%, 20%). (3) Results: From a societal perspective, for the efficacy of 15% or 20%, MS sherpa became dominant, which means cost-saving compared to the standard of care. MS sherpa is cost-effective in the 5% and 10% scenarios (ICERs EUR 14,535 and EUR 4069, respectively). From the health care perspective, all scenarios were cost-effective. Sensitivity analysis showed that increasing the efficacy of MS sherpa in detecting active disease early leading to treatment switches be the most impactful factor in the MS model. (4) Conclusions: The results indicate the potential of eHealth interventions to be cost-effective or even cost-saving in the MS care path. As such, digital biomarker–based eHealth interventions, like MS sherpa, are promising cost-effective solutions in optimizing MS disease management for people with MS, by detecting active disease early and helping neurologists in decisions on treatment switch.
APA, Harvard, Vancouver, ISO, and other styles
10

Flück, Daniela, Laura E. Morris, Shailesh Niroula, Christine M. Tallon, Kami T. Sherpa, Mike Stembridge, Philip N. Ainslie, and Ali M. McManus. "UBC-Nepal expedition: markedly lower cerebral blood flow in high-altitude Sherpa children compared with children residing at sea level." Journal of Applied Physiology 123, no. 4 (October 1, 2017): 1003–10. http://dx.doi.org/10.1152/japplphysiol.00292.2017.

Full text
Abstract:
Developmental cerebral hemodynamic adaptations to chronic high-altitude exposure, such as in the Sherpa population, are largely unknown. To examine hemodynamic adaptations in the developing human brain, we assessed common carotid (CCA), internal carotid (ICA), and vertebral artery (VA) flow and middle cerebral artery (MCA) velocity in 25 (9.6 ± 1.0 yr old, 129 ± 9 cm, 27 ± 8 kg, 14 girls) Sherpa children (3,800 m, Nepal) and 25 (9.9 ± 0.7 yr old, 143 ± 7 cm, 34 ± 6 kg, 14 girls) age-matched sea level children (344 m, Canada) during supine rest. Resting gas exchange, blood pressure, oxygen saturation and heart rate were assessed. Despite comparable age, height and weight were lower (both P < 0.01) in Sherpa compared with sea level children. Mean arterial pressure, heart rate, and ventilation were similar, whereas oxygen saturation (95 ± 2 vs. 99 ± 1%, P < 0.01) and end-tidal Pco2 (24 ± 3 vs. 36 ± 3 Torr, P < 0.01) were lower in Sherpa children. Global cerebral blood flow was ∼30% lower in Sherpa compared with sea level children. This was reflected in a lower ICA flow (283 ± 108 vs. 333 ± 56 ml/min, P = 0.05), VA flow (78 ± 26 vs. 118 ± 35 ml/min, P < 0.05), and MCA velocity (72 ± 14 vs. 88 ± 14 cm/s, P < 0.01). CCA flow was similar between Sherpa and sea level children (425 ± 92 vs. 441 ± 81 ml/min, P = 0.52). Scaling flow and oxygen uptake for differences in vessel diameter and body size, respectively, led to the same findings. A lower cerebral blood flow in Sherpa children may reflect specific cerebral hemodynamic adaptations to chronic hypoxia. NEW & NOTEWORTHY Cerebral blood flow is lower in Sherpa children compared with children residing at sea level; this may reflect a cerebral hemodynamic pattern, potentially due to adaptation to a hypoxic environment.
APA, Harvard, Vancouver, ISO, and other styles
11

Swancutt, D., E. Jack, H. Neve, J. Tredinnick-Rowe, N. Axford, and R. Byng. "26 Introducing the Sherpa Model for Managing Multi-Morbidity to Trainee GPS: Outcomes and Relevance to Elderly CareÂ." Age and Ageing 50, Supplement_1 (March 2021): i7—i11. http://dx.doi.org/10.1093/ageing/afab029.05.

Full text
Abstract:
Abstract Background Primary care trainees are traditionally taught to use a consultation model which focuses on eliciting the patients’ main reason for consulting “today”. As the number of patients with multi-morbidity increases, this approach is often inappropriate or unhelpful. Patients can be left without an understanding of their interacting health issues. The SHERPA model provides a biopsychosocial framework for consulting patients with multi-morbidity. We aimed to examine the responses to this model when integrated into a training programme for newly registered GPs. Methods Sixteen participants provide qualitative data on their experience and follow-up use of SHERPA. Four hours of teaching were observed. Twenty-four feedback templates on training (n = 18) and SHERPA application (n = 6) were collected. Individual semi-structured one-to-one interviews were conducted with trainees (n = 5) and trainers (n = 3). Data were transcribed and, using the Framework approach, systematically analysed focussing on the trainees’ reaction to the teaching sessions and their ability to use the SHERPA consultation model. Results Participants engaged well with the teaching sessions, enjoying the scenarios and bringing observations from their own experience. Five participants went on to apply SHERPA successfully with their patients. Barriers to using this approach were: not seeing appropriate patients with multi-morbidities (due to current placement or patient type); time; lack of confidence and familiarity; concern about missing important immediate clinical issues; and viewing the approach as “in addition” rather than key to shared decision-making. Conclusion The SHERPA model was viewed as a helpful addition by trainee GPs, although practical issues, fears and not seeing it as their priority for their case-mix, limited their application of it. Regular support from trainers, where trainees reflect on their experience of using SHERPA, could increase their confidence and familiarity with this method. These findings suggest that SHERPA may be relevant to other specialities such as geriatric medicine, where multi-morbidity is common.
APA, Harvard, Vancouver, ISO, and other styles
12

Cooper, Brian F., P. P. S. Narayan, Raghu Ramakrishnan, Utkarsh Srivastava, Adam Silberstein, Philip Bohannon, Hans-Arno Jacobsen, Nick Puz, Daniel Weaver, and Ramana Yerneni. "PNUTS to Sherpa." Proceedings of the VLDB Endowment 12, no. 12 (August 2019): 2300–2307. http://dx.doi.org/10.14778/3352063.3352146.

Full text
APA, Harvard, Vancouver, ISO, and other styles
13

Schweitzer, Helmuth. "Management by Sherpa." Sozial Extra 43, no. 2 (March 20, 2019): 88–91. http://dx.doi.org/10.1007/s12054-019-00166-5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

Tremblay, Joshua C., Ryan L. Hoiland, Howard H. Carter, Connor A. Howe, Mike Stembridge, Christopher K. Willie, Christopher Gasho, David B. MacLeod, Kyra E. Pyke, and Philip N. Ainslie. "UBC-Nepal expedition: upper and lower limb conduit artery shear stress and flow-mediated dilation on ascent to 5,050 m in lowlanders and Sherpa." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 6 (December 1, 2018): H1532—H1543. http://dx.doi.org/10.1152/ajpheart.00345.2018.

Full text
Abstract:
The study of conduit artery endothelial adaptation to hypoxia has been restricted to the brachial artery, and comparisons with highlanders have been confounded by differences in altitude exposure, exercise, and unknown levels of blood viscosity. To address these gaps, we tested the hypothesis that lowlanders, but not Sherpa, would demonstrate decreased mean shear stress and increased retrograde shear stress and subsequently reduced flow-mediated dilation (FMD) in the upper and lower limb conduit arteries on ascent to 5,050 m. Healthy lowlanders (means ± SD, n = 22, 28 ± 6 yr) and Sherpa ( n = 12, 34 ± 11 yr) ascended over 10 days, with measurements taken on nontrekking days at 1,400 m (baseline), 3,440 m ( day 4), 4,371 m ( day 7), and 5,050 m ( day 10). Arterial blood gases, blood viscosity, shear stress, and FMD [duplex ultrasound of the brachial and superficial femoral arteries (BA and SFA, respectively)] were acquired at each time point. Ascent decreased mean and increased retrograde shear stress in the upper and lower limb of lowlanders and Sherpa. Although BA FMD decreased in lowlanders from 7.1 ± 3.9% to 3.8 ± 2.8% at 5,050 versus 1,400 m ( P < 0.001), SFA FMD was preserved. In Sherpa, neither BA nor SFA FMD were changed upon ascent to 5,050 m. In lowlanders, the ascent-related exercise may favorably influence endothelial function in the active limb (SFA); selective impairment in FMD in the BA in lowlanders is likely mediated via the low mean or high oscillatory baseline shear stress. In contrast, Sherpa presented protected endothelial function, suggesting a potential vascular aspect of high-altitude acclimatization/adaptation. NEW & NOTEWORTHY Upper and lower limb arterial shear stress and flow-mediated dilation (FMD) were assessed on matched ascent from 1,400 to 5,050 m in lowlanders and Sherpa. A shear stress pattern associated with vascular dysfunction/risk manifested in both limbs of lowlanders and Sherpa. FMD was impaired only in the upper limb of lowlanders. The findings indicate a limb-specific impact of high-altitude trekking on FMD and a vascular basis to acclimatization wherein endothelial function is protected in Sherpa on ascent
APA, Harvard, Vancouver, ISO, and other styles
15

Stembridge, Mike, Alexandra M. Williams, Christopher Gasho, Tony G. Dawkins, Aimee Drane, Francisco C. Villafuerte, Benjamin D. Levine, Rob Shave, and Philip N. Ainslie. "The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives." Proceedings of the National Academy of Sciences 116, no. 33 (July 29, 2019): 16177–79. http://dx.doi.org/10.1073/pnas.1909002116.

Full text
Abstract:
In contrast to Andean natives, high-altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity. Decades of physiological and genomic research have assumed that the lower hemoglobin concentration in Himalayan natives results from a blunted erythropoietic response to hypoxia (i.e., no increase in total hemoglobin mass). In contrast, herein we test the hypothesis that the lower hemoglobin concentration is the result of greater plasma volume, rather than an absence of increased hemoglobin production. We assessed hemoglobin mass, plasma volume and blood volume in lowlanders at sea level, lowlanders acclimatized to high altitude, Himalayan Sherpa, and Andean Quechua, and explored the functional relevance of volumetric hematological measures to exercise capacity. Hemoglobin mass was highest in Andeans, but also was elevated in Sherpa compared with lowlanders. Sherpa demonstrated a larger plasma volume than Andeans, resulting in a comparable total blood volume at a lower hemoglobin concentration. Hemoglobin mass was positively related to exercise capacity in lowlanders at sea level and in Sherpa at high altitude, but not in Andean natives. Collectively, our findings demonstrate a unique adaptation in Sherpa that reorientates attention away from hemoglobin concentration and toward a paradigm where hemoglobin mass and plasma volume may represent phenotypes with adaptive significance at high altitude.
APA, Harvard, Vancouver, ISO, and other styles
16

Stembridge, Mike, Philip N. Ainslie, Michael G. Hughes, Eric J. Stöhr, James D. Cotter, Amanda Q. X. Nio, and Rob Shave. "Ventricular structure, function, and mechanics at high altitude: chronic remodeling in Sherpa vs. short-term lowlander adaptation." Journal of Applied Physiology 117, no. 3 (August 1, 2014): 334–43. http://dx.doi.org/10.1152/japplphysiol.00233.2014.

Full text
Abstract:
Short-term, high-altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left-ventricular (LV) volumes. However, relatively little is known of the long-term cardiac consequences of prolonged exposure in Sherpa, a highly adapted HA population. To investigate short-term adaptation and potential long-term cardiac remodeling, we studied ventricular structure and function in Sherpa at 5,050 m ( n = 11; 31 ± 13 yr; mass 68 ± 10 kg; height 169 ± 6 cm) and lowlanders at sea level (SL) and following 10 ± 3 days at 5,050 m ( n = 9; 34 ± 7 yr; mass 82 ± 10 kg; height 177 ± 6 cm) using conventional and speckle-tracking echocardiography. At HA, PASP was higher in Sherpa and lowlanders compared with lowlanders at SL (both P < 0.05). Sherpa had smaller right-ventricular (RV) and LV stroke volumes than lowlanders at SL with lower RV systolic strain ( P < 0.05) but similar LV systolic mechanics. In contrast to LV systolic mechanics, LV diastolic, untwisting velocity was significantly lower in Sherpa compared with lowlanders at both SL and HA. After partial acclimatization, lowlanders demonstrated no change in the RV end-diastolic area; however, both RV strain and LV end-diastolic volume were reduced. In conclusion, short-term hypoxia induced a reduction in RV systolic function that was also evident in Sherpa following chronic exposure. We propose that this was consequent to a persistently higher PASP. In contrast to the RV, remodeling of LV volumes and normalization of systolic mechanics indicate structural and functional adaptation to HA. However, altered LV diastolic relaxation after chronic hypoxic exposure may reflect differential remodeling of systolic and diastolic LV function.
APA, Harvard, Vancouver, ISO, and other styles
17

Rai, Dhyanendra Bahadur. "Tourism development and economic and socio-cultural consequences in Everest Region." Geographical Journal of Nepal 10 (May 31, 2017): 89–104. http://dx.doi.org/10.3126/gjn.v10i0.17392.

Full text
Abstract:
Being a mountainous country, Nepal is one of the destinations of tourist. Everest Region is one of the major destination trekking and mountaineering tourism and ranks second after Annapurna Region in term of number of tourists visiting different regions of Nepal. The number of tourist visiting this region increased from only 1406 in 1971/72 to 37124 in 2014. Such a growth of tourism has several socio-economic and cultural consequences. This paper discusses the consequences of tourism in Everest Region. Informations were collected along the trekking routes from Lukla to Dinboche through focus group discussion, key informant interview and tourism business survey. The results indicate that the number of hotels and lodges in many settlements along the trekking route has increased tremendously. The main base of economic life of Sherpa community has been changed from agro-pastoralism to tourism based business. The level of employment and income of local people has improved. However, tourism has undermined Sherpa culture by introducing new values and lifestyles influencing from westerners, eroded the central role of religion and traditional value in Sherpa community. For the younger generation the tourist and their norms of behavior and patterns of consumption can be seductive. This is the symptom of losing of cultural value of Sherpa community and world identity of Sherpa in the future.The Geographical Journal of Nepal Vol. 10: 89-104, 2017
APA, Harvard, Vancouver, ISO, and other styles
18

Rijal, Chanakya P. "Sustainable Mountain Tourism Development in Khumbu Region." Gaze: Journal of Tourism and Hospitality 6 (June 21, 2016): 42–69. http://dx.doi.org/10.3126/gaze.v6i0.15114.

Full text
Abstract:
As a result of highly impressive socio-behavioral temperament and character of the Sherpas in the eastern mountains, many people may be influenced to visit Nepal again and again and the outcome could be the spread of global brotherhood of the Nepalese people. The Sherpas are regarded as the symbolic source of inspiration by means of their simplicity of living, grounded religious and spiritual faith and trustworthiness - all contributing in an experiential living in the Himalayas. This article presents with an exploration of the problems, challenges and prospects for promoting sustainable mountain tourism keeping the Hilarity of the Sherpa Spirit at the center of concern while establishing a world view on sustainable tourism development and supplementing it with the grounded multiple realities via ethnographic dialectics.The Gaze: Journal of Tourism and Hospitality Vol.6 2014 pp.42-69
APA, Harvard, Vancouver, ISO, and other styles
19

Busch, Stephen A., Lydia L. Simpson, Frances Sobierajski, Laurel Riske, Philip N. Ainslie, Chris K. Willie, Mike Stembridge, Jonathan P. Moore, and Craig D. Steinback. "Muscle sympathetic reactivity to apneic and exercise stress in high-altitude Sherpa." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318, no. 3 (March 1, 2020): R493—R502. http://dx.doi.org/10.1152/ajpregu.00119.2019.

Full text
Abstract:
Lowland-dwelling populations exhibit persistent sympathetic hyperactivity at altitude that alters vascular function. High-altitude populations, such as Sherpa, have previously exhibited greater peripheral blood flow in response to acute stress than Lowlanders, which may be explained through lower sympathetic activity. Our purpose was to determine whether Sherpa exhibit lower sympathetic reactivity to stress than Lowlanders. Muscle sympathetic nerve activity (MSNA; microneurography) was measured at rest in Lowlanders ( n = 14; age = 27 ± 6 yr) at 344 m and between 1 and 10 days at 5,050 m. Sherpa (age = 32 ± 11 yr) were tested at 5,050 m ( n = 8). Neurovascular reactivity (i.e., change in MSNA patterns) was measured during maximal end-expiratory apnea, isometric hand grip (IHG; 30% maximal voluntary contraction for 2-min), and postexercise circulatory occlusion (PECO; 3 min). Burst frequency (bursts/min) and incidence (bursts/100 heartbeats) and total normalized SNA (arbitrary units/min) were analyzed at rest, immediately before apnea breakpoint, and during the last minute of IHG and PECO. Vascular responses to apnea, IHG, and PECO were also measured. MSNA reactivity to apnea was smaller in Sherpa than Lowlanders at 5,050 m, although blood pressure responses were similar between groups. MSNA increases in Lowlanders during apnea at 5,050 m were significantly lower than at 344 m ( P < 0.05), indicating that a possible sympathetic ceiling was reached in Lowlanders at 5,050 m. MSNA increased similarly during IHG and PECO in Lowlanders at both 334 m and 5,050 m and in Sherpa at 5,050 m, while vascular changes (mean brachial arterial pressure, contralateral brachial flow and resistance) were similar between groups. Sherpa demonstrate overall lower sympathetic reactivity that may be a result of heightened vascular responsiveness to potential apneic stress at altitude.
APA, Harvard, Vancouver, ISO, and other styles
20

Busch, Stephen A., Hannah Davies, Sean van Diepen, Lydia L. Simpson, Frances Sobierajski, Laurel Riske, Mike Stembridge, et al. "Chemoreflex mediated arrhythmia during apnea at 5,050 m in low- but not high-altitude natives." Journal of Applied Physiology 124, no. 4 (April 1, 2018): 930–37. http://dx.doi.org/10.1152/japplphysiol.00774.2017.

Full text
Abstract:
Peripheral chemoreflex mediated increases in both parasympathetic and sympathetic drive under chronic hypoxia may evoke bradyarrhythmias during apneic periods. We determined whether 1) voluntary apnea unmasks arrhythmia at low (344 m) and high (5,050 m) altitude, 2) high-altitude natives (Nepalese Sherpa) exhibit similar cardiovagal responses at altitude, and 3) bradyarrhythmias at altitude are partially chemoreflex mediated. Participants were grouped as Lowlanders ( n = 14; age = 27 ± 6 yr) and Nepalese Sherpa ( n = 8; age = 32 ± 11 yr). Lowlanders were assessed at 344 and 5,050 m, whereas Sherpa were assessed at 5,050 m. Heart rate (HR) and rhythm (lead II ECG) were recorded during rest and voluntary end-expiratory apnea. Peripheral chemoreflex contributions were assessed in Lowlanders ( n = 7) at altitude after 100% oxygen. Lowlanders had higher resting HR at altitude (70 ± 15 vs. 61 ± 15 beats/min; P < 0.01) that was similar to Sherpa (71 ± 5 beats/min; P = 0.94). High-altitude apnea caused arrhythmias in 11 of 14 Lowlanders [junctional rhythm ( n = 4), 3° atrioventricular block ( n = 3), sinus pause ( n = 4)] not present at low altitude and larger marked bradycardia (nadir −39 ± 18 beats/min; P < 0.001). Sherpa exhibited a reduced bradycardia response during apnea compared with Lowlanders ( P < 0.001) and did not develop arrhythmias. Hyperoxia blunted bradycardia (nadir −10 ± 14 beats/min; P < 0.001 compared with hypoxic state) and reduced arrhythmia incidence (3 of 7 Lowlanders). Degree of bradycardia was significantly related to hypoxic ventilatory response (HVR) at altitude and predictive of arrhythmias ( P < 0.05). Our data demonstrate apnea-induced bradyarrhythmias in Lowlanders at altitude but not in Sherpa (potentially through cardioprotective phenotypes). The chemoreflex is an important mechanism in genesis of bradyarrhythmias, and the HVR may be predictive for identifying individual susceptibility to events at altitude. NEW & NOTEWORTHY The peripheral chemoreflex increases both parasympathetic and sympathetic drive under chronic hypoxia. We found that this evoked bradyarrhythmias when combined with apneic periods in Lowlanders at altitude, which become relieved through supplemental oxygen. In contrast, high-altitude residents (Nepalese Sherpa) do not exhibit bradyarrhythmias during apnea at altitude through potential cardioprotective adaptations. The degree of bradycardia and bradyarrhythmias was related to the hypoxic ventilatory response, demonstrating that the chemoreflex plays an important role in these findings.
APA, Harvard, Vancouver, ISO, and other styles
21

Hubbard, Bill. "SHERPA and institutional repositories." Serials: The Journal for the Serials Community 16, no. 3 (November 1, 2003): 243–47. http://dx.doi.org/10.1629/16243.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Archibald, Jennifer, Tanju Gleisberg, Stefan Höche, Frank Krauss, Marek Schönherr, Steffen Schumann, Frank Siegert, and Jan Winter. "Recent developments in SHERPA." Nuclear Physics B - Proceedings Supplements 183 (October 2008): 60–66. http://dx.doi.org/10.1016/j.nuclphysbps.2008.09.083.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Heydon, S. "Taking medicines: Sherpa perspectives." Research in Social and Administrative Pharmacy 8, no. 6 (November 2012): e20-e21. http://dx.doi.org/10.1016/j.sapharm.2012.08.048.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Subedi, Bishnu Hari, Jhapindra Pokharel, Rachana Thapa, Nalin Banskota, and Buddha Basnyat. "Frostbite in a Sherpa." Wilderness & Environmental Medicine 21, no. 2 (June 2010): 127–29. http://dx.doi.org/10.1016/j.wem.2009.12.031.

Full text
APA, Harvard, Vancouver, ISO, and other styles
25

Stembridge, Mike, Philip N. Ainslie, Joseph Donnelly, Nicholas T. MacLeod, Suchita Joshi, Michael G. Hughes, Kami Sherpa, and Rob Shave. "Cardiac structure and function in adolescent Sherpa; effect of habitual altitude and developmental stage." American Journal of Physiology-Heart and Circulatory Physiology 310, no. 6 (March 15, 2016): H740—H746. http://dx.doi.org/10.1152/ajpheart.00938.2015.

Full text
Abstract:
The purpose of this study was to examine ventricular structure and function in Sherpa adolescents to determine whether age-specific differences in oxygen saturation (SpO2) and pulmonary artery systolic pressure (PASP) influence cardiac adaptation to chronic hypoxia early in life. Two-dimensional, Doppler, and speckle-tracking echocardiography were performed on adolescent (9–16 yr) highland Sherpa (HLS; 3,840 m; n = 26) and compared with age-matched lowland Sherpa (LLS; 1,400 m; n = 10) and lowland Caucasian controls (LLC; sea level; n = 30). The HLS were subdivided into pre- and postadolescence; SpO2 was also recorded. Only HLS exhibited a smaller relative left ventricular (LV) end-diastolic volume; however, both HLS and LLS demonstrated a lower peak LV untwisting velocity compared with LLC (92 ± 26 and 100 ± 45 vs. 130 ± 43°/s, P < 0.05). Although SpO2 was similar between groups, PASP was higher in post- vs. preadolescent HLS (30 ± 5 vs. 25 ± 5 mmHg, P < 0.05), which negatively correlated with right ventricular strain rate ( r = 0.50, P < 0.01). Much like their adult counterparts, HLS and LLS adolescents exhibit slower LV diastolic relaxation, despite residing at different altitudes. These findings suggest fundamental differences exist in the diastolic function of Sherpa that are present at an early age and may be retained after migration to lower altitudes. The higher PASP in postadolescent Sherpa is in contrast to previous reports of lowland children at high altitude and, unlike that in lowlanders, was not explained by differences in SpO2; thus different regulatory mechanisms seem to exist between these two distinct populations.
APA, Harvard, Vancouver, ISO, and other styles
26

Tymko, Michael M., Christopher K. Willie, Connor A. Howe, Ryan L. Hoiland, Rachel M. Stone, Kaitlyn Tymko, Courtney Tymko, et al. "Acid-base balance at high altitude in lowlanders and indigenous highlanders." Journal of Applied Physiology 132, no. 2 (February 1, 2022): 575–80. http://dx.doi.org/10.1152/japplphysiol.00757.2021.

Full text
Abstract:
Lowlander, Andean, and Sherpa arterial blood data were combined across five independent high-altitude expeditions in the United States, Nepal, and Peru to assess acid-base status at ∼3,800, ∼4,300, and ∼5,000 m. The main finding was that Andean and Sherpa highlander populations have more acidic arterial blood, due to elevated arterial carbon dioxide and similar arterial bicarbonate compared with acclimatizing lowlanders at altitudes ≥4,300 m.
APA, Harvard, Vancouver, ISO, and other styles
27

Karki, Arjun, and Kapil Kafle. "Livelihood Dissonance in Sherpa Community." International Journal of Social Sciences and Management 7, no. 3 (July 27, 2020): 159–68. http://dx.doi.org/10.3126/ijssm.v7i3.29958.

Full text
Abstract:
This study deals with the changing occupations of Sherpa people who has been recognized as 'high altitude porter' for their courage in climbing difficult mountains. After having a lot of in person formal/informal conversation, focus group discussion and in field observations for 15 days with heterogeneous people in Khumbu region of Nepal, the study tried to find reasons of distractions of younger generation in maintaining their ancestral professions. Narrative interview has been conducted with Sherpa mountaineers, business persons, porters, young students and teachers. An effort has been made to analyze the issues of Sherpa community people through cognitive dissonance theory developed by Leon Festinger in 1957. It employs thematic analysis in three categories of participants – professional mountaineers, business people (age: 20 to 35) and high school students (age: 16 to 20) and findings have been discussed under theoretical and policies perspectives. The findings show that Sherpa people are reluctant to continue their ancestral climbing profession because of risks of life, pressure built from their family members, lack of encouragement from the Government and availability of alternatives. The study has reflected many possibilities of future research. The lapses are found in policies, relevant educational curricula, facilities and protection and promotion mechanism of tourism industries, thus, studies in these areas can help shed light on the overall situations of professionalism in this sector. Int. J. Soc. Sc. Manage. Vol. 7, Issue-3: 159-168
APA, Harvard, Vancouver, ISO, and other styles
28

Catelani, Marcantonio, Lorenzo Ciani, Giulia Guidi, and Gabriele Patrizi. "An enhanced SHERPA (E-SHERPA) method for human reliability analysis in railway engineering." Reliability Engineering & System Safety 215 (November 2021): 107866. http://dx.doi.org/10.1016/j.ress.2021.107866.

Full text
APA, Harvard, Vancouver, ISO, and other styles
29

Mataina, Wichamdinbo. "Sociolinguistic Profile of Sherpa in Sikkim." Nepalese Linguistics 36, no. 1 (November 14, 2022): 39–45. http://dx.doi.org/10.3126/nl.v36i1.49456.

Full text
Abstract:
The study is based on the primary data collected during 2017 and 2018 in Sikkim using the questionnaire designed by the Centre for Endangered Languages, Sikkim University. Information about number of speakers, language vitality, domains of usage and causes of language endangerment were collected from the consultants who were both male and female from age 26 to 85 years with various occupational background. The study found that though the Sherpa speakers are positive towards their language, it is quite worrisome about the sustainability of Sherpa language in practice.
APA, Harvard, Vancouver, ISO, and other styles
30

Tinkler, Linda. "Every organisation needs a Sherpa." British Journal of Nursing 31, no. 9 (May 12, 2022): 506–7. http://dx.doi.org/10.12968/bjon.2022.31.9.506.

Full text
APA, Harvard, Vancouver, ISO, and other styles
31

Gleisberg, T., S. Höche, F. Krauss, M. Schönherr, S. Schumann, F. Siegert, and J. Winter. "Event generation with SHERPA 1.1." Journal of High Energy Physics 2009, no. 02 (February 3, 2009): 007. http://dx.doi.org/10.1088/1126-6708/2009/02/007.

Full text
APA, Harvard, Vancouver, ISO, and other styles
32

Wong, Elise Y. "SHERPA/JULIET; http://www.sherpa.ac.uk/juliet/." Technical Services Quarterly 32, no. 3 (June 15, 2015): 351–52. http://dx.doi.org/10.1080/07317131.2015.1032091.

Full text
APA, Harvard, Vancouver, ISO, and other styles
33

Adams, Vincanne. "Dreams of a Final Sherpa." American Anthropologist 99, no. 1 (March 1997): 85–98. http://dx.doi.org/10.1525/aa.1997.99.1.85.

Full text
APA, Harvard, Vancouver, ISO, and other styles
34

Janßen, T., and S. Schumann. "Machine learning efforts in Sherpa." Journal of Physics: Conference Series 2438, no. 1 (February 1, 2023): 012144. http://dx.doi.org/10.1088/1742-6596/2438/1/012144.

Full text
Abstract:
Abstract Modern machine learning methods offer great potential for increasing the efficiency of Monte Carlo event generators. We present the latest developments in the context of the SHERPA event generation framework. These include phase space sampling amended by normalizing flows and a new unweighting procedure based on neural-network surrogates for the full matrix elements. We discuss corresponding general construction criteria and show examples of efficiency gains for selected LHC production processes.
APA, Harvard, Vancouver, ISO, and other styles
35

Garrido, Eduardo, Ramón Segura, Antoni Capdevila, Jesús Pujol, Casimiro Javierre, and Josep Li Ventura. "Are Himalayan Sherpas Better Protected against Brain Damage Associated with Extreme Altitude Climbs?" Clinical Science 90, no. 1 (January 1, 1996): 81–85. http://dx.doi.org/10.1042/cs0900081.

Full text
Abstract:
1. The potential risk of brain damage when low-landers attempt to climb the highest summits is a well-known fact. However, very little is known about what occurs to Himalayan natives, perfectly adapted to high altitude, when performing the same type of activity. 2. Taking into account their long-life climbing experience at extreme altitudes, we examined seven of the most recognized Sherpas with the aim of performing a comprehensive neurological evaluation based on medical history, physical examination and magnetic resonance brain imaging. We compared them with one group of 21 lowland elite climbers who had ascended to altitudes of over 8000 m, and another control group of 21 healthy individuals who had never been exposed to high altitude. 3. While all of the lowland climbers presented psychoneurological symptoms during or after the expeditions, and 13 of them (61%) showed magnetic resonance abnormalities (signs of mild cortical atrophy and/or periventricular high-intensity signal areas in the white matter), only one Sherpa (14%) showed similar changes in the scans, presenting neurological symptoms at extreme altitude. The neurological examination was normal in all three groups, and no neuroimaging abnormalities were detected in the control group. 4. The significant differences, in both clinical and neuroimaging terms, suggest that Sherpa highlanders have better brain protection when exposed to extreme altitude. Although the key to protection against cerebral hypoxia cannot be established, it is possible that an increase in the usually short period of acclimatization could minimize brain damage in those low-landers who attempt the highest summits without supplementary oxygen.
APA, Harvard, Vancouver, ISO, and other styles
36

Ashour, Ahmed, Denham L. Phipps, and Darren M. Ashcroft. "Predicting dispensing errors in community pharmacies: An application of the Systematic Human Error Reduction and Prediction Approach (SHERPA)." PLOS ONE 17, no. 1 (January 4, 2022): e0261672. http://dx.doi.org/10.1371/journal.pone.0261672.

Full text
Abstract:
Introduction The objective of this study was to use a prospective error analysis method to examine the process of dispensing medication in community pharmacy settings and identify remedial solutions to avoid potential errors, categorising them as strong, intermediate, or weak based on an established patient safety action hierarchy tool. Method Focus group discussions and non-participant observations were undertaken to develop a Hierarchical Task Analysis (HTA), and subsequent focus group discussions applied the Systematic Human Error Reduction and Prediction Approach (SHERPA) focusing on the task of dispensing medication in community pharmacies. Remedial measures identified through the SHERPA analysis were then categorised as strong, intermediate, or weak based on the Veteran Affairs National Centre for Patient Safety action hierarchy. Non-participant observations were conducted at 3 pharmacies, totalling 12 hours, based in England. Additionally, 7 community pharmacists, with experience ranging from 8 to 38 years, participated in a total of 4 focus groups, each lasting between 57 to 85 minutes, with one focus group discussing the HTA and three applying SHERPA. A HTA was produced consisting of 10 sub-tasks, with further levels of sub-tasks within each of them. Results Overall, 88 potential errors were identified, with a total of 35 remedial solutions proposed to avoid these errors in practice. Sixteen (46%) of these remedial measures were categorised as weak, 14 (40%) as intermediate and 5 (14%) as strong according to the Veteran Affairs National Centre for Patient Safety action hierarchy. Sub-tasks with the most potential errors were identified, which included ‘producing medication labels’ and ‘final checking of medicines’. The most common type of error determined from the SHERPA analysis related to omitting a check during the dispensing process which accounted for 19 potential errors. Discussion This work applies both HTA and SHERPA for the first time to the task of dispensing medication in community pharmacies, detailing the complexity of the task and highlighting potential errors and remedial measures specific to this task. Future research should examine the effectiveness of the proposed remedial solutions to improve patient safety.
APA, Harvard, Vancouver, ISO, and other styles
37

Holden, J. E., C. K. Stone, C. M. Clark, W. D. Brown, R. J. Nickles, C. Stanley, and P. W. Hochachka. "Enhanced cardiac metabolism of plasma glucose in high-altitude natives: adaptation against chronic hypoxia." Journal of Applied Physiology 79, no. 1 (July 1, 1995): 222–28. http://dx.doi.org/10.1152/jappl.1995.79.1.222.

Full text
Abstract:
The metabolism of glucose in mammalian heart is 25–50% more O2 efficient than the metabolism of free fatty acids. To assess the role of substrate preference in adaptations to chronic hypoxia, positron emission tomographic measurements of heart regional glucose uptake rates after an overnight fast were made in volunteer Quechua subjects and in Sherpa subjects, both indigenous to altitudes of over 3,000 m, and in a group of lowlander volunteers. Highest uptake rates were found in the Quechuas on arrival and in the Sherpas after a 3-wk period at low altitude, intermediate rates in Quechuas after a 3-wk period at low altitude and in the lowlanders, and lowest rates in Sherpas on arrival. These low values were probably related to the stress of travel to the site of the experiments. Measured plasma catecholamines, hormones, and substrates indicated that glucose concentrations correlated best with observed variations in glucose uptake, with a negative correlation for the control subjects and a positive correlation for the Quechuas and Sherpas. Uptake values in Quechuas declined significantly after a 3-wk period at low altitude, but the positive correlation with glucose levels persisted. We conclude that an elevated glucose preference in heart is a true metabolic adaptation in humans adapted over generations to chronic hypoxia.
APA, Harvard, Vancouver, ISO, and other styles
38

Sherpa, Pasang. "Climate Change, Perceptions, and Social Heterogeneity in Pharak, Mount Everest Region of Nepal." Human Organization 73, no. 2 (May 1, 2014): 153–61. http://dx.doi.org/10.17730/humo.73.2.94q43152111733t6.

Full text
Abstract:
Based on 15 months of research conducted between 2010 and 2012, this paper examines how climate change is unfolding for Sherpas in Pharak, the southern part of Nepal's Everest region. Sherpas are noticing environmental changes, undergoing socioeconomic transformation, being introduced to climate change, and becoming exposed to multiple forms of environmental knowledge from various sources. Thus, climate change in this research emerges as an issue not contained within a single geographic territory or an academic discipline but as the product of multiple knowledge systems in addition to observable effects on the natural environment. This research reveals the narrowly defined institutional climate change narratives that focus on melting of glaciers and glacial lake outburst floods. I argue that a sustained emphasis on such institutional narratives will obscure the wider range of both short- and long-term climate change effects and thereby limit our understanding of their impacts on the residents of this region. I further argue that in order to understand Sherpa perceptions of climate change, it is necessary to understand the exposure and access of individual Sherpas to various sources of knowledge and resources. This can be achieved by exploring social heterogeneity and understanding how social networks function in this small-scale cultural group.
APA, Harvard, Vancouver, ISO, and other styles
39

Gilbert-Kawai, Edward T., James S. Milledge, Michael P. W. Grocott, and Daniel S. Martin. "King of the Mountains: Tibetan and Sherpa Physiological Adaptations for Life at High Altitude." Physiology 29, no. 6 (November 2014): 388–402. http://dx.doi.org/10.1152/physiol.00018.2014.

Full text
Abstract:
Anecdotal evidence surrounding Tibetans' and Sherpas' exceptional tolerance to hypobaric hypoxia has been recorded since the beginning of high-altitude exploration. These populations have successfully lived and reproduced at high altitude for hundreds of generations with hypoxia as a constant evolutionary pressure. Consequently, they are likely to have undergone natural selection toward a genotype (and phenotype) tending to offer beneficial adaptation to sustained hypoxia. With the advent of translational human hypoxic research, in which genotype/phenotype studies of healthy individuals at high altitude may be of benefit to hypoxemic critically ill patients in a hospital setting, high-altitude natives may provide a valuable and intriguing model. The aim of this review is to provide a comprehensive summary of the scientific literature encompassing Tibetan and Sherpa physiological adaptations to a high-altitude residence. The review demonstrates the extent to which evolutionary pressure has refined the physiology of this high-altitude population. Furthermore, although many physiological differences between highlanders and lowlanders have been found, it also suggests many more potential avenues of investigation.
APA, Harvard, Vancouver, ISO, and other styles
40

Sherpa शेर्पा, दावा Daba. "शेर्पा भाषाको शब्दवर्ग Sherpa Bhashako Shabdabarga." Tribhuvan University Journal 29, no. 1 (March 31, 2016): 223–30. http://dx.doi.org/10.3126/tuj.v29i1.25986.

Full text
Abstract:
नेपालको हिमाली क्षेत्रमा बसोवास गर्ने शेर्पा जातिले बोल्ने भाषालाई शेर्पा भाषा भनिन्छ । यो भाषा भोटवर्मेली भाषा परिवारअन्तर्गत पर्दछ । २०६८ सालको जनगणनाअनुसार एकलाख चौधहजार आठसय तीस अर्थात् शेर्पा भाषा बोल्नेको सङ्ख्या कुल जनसङ्ख्याको ०.४३ प्रतिशत मात्र रहेको तथ्याङ्क देखिन्छ । यस लेखमा क्षेत्रीय सर्वेक्षण विधिद्वारा सङ्कलित सामग्रीका आधारमा शेर्पा भाषाका शब्दवर्गहरू पहिचान गरी नेपाली भाषा र शेर्पा भाषाका शब्दवर्गको तुलनात्मक अध्ययन प्रस्तुत गरिएको छ । शेर्पा भाषाका शब्दवर्गमा नाममा व्यक्तिवाचक, जातिवाचक, द्रव्यवाचक, समूहवाचक र भाववाचक रहेका छन् भने सर्वनाममा पुरुषवाचक प्रथम, द्वितीय र तृतीय पुरुष एकवचन अनि बहुवचन पाइन्छ । आत्मवाचक, दर्शकवाचक र प्रश्नवाचक सर्वनाम रहेको पाइन्छ ।विशेषणमा गुणवाचक, परिणामवाचक, सङ्ख्यावाचक र सार्वनामिक विशेषण पाइन्छन् । क्रियापदमा भने सकर्मक, अकर्मक, समापिका, असमापिका क्रिया पाइन्छन् भने क्रियाविशेषण, नामयोगी, संयोजक र विस्मयादिबोधक आदि अव्यय पनि पाइन्छन् ।
APA, Harvard, Vancouver, ISO, and other styles
41

Horscroft, James A., Aleksandra O. Kotwica, Verena Laner, James A. West, Philip J. Hennis, Denny Z. H. Levett, David J. Howard, et al. "Metabolic basis to Sherpa altitude adaptation." Proceedings of the National Academy of Sciences 114, no. 24 (May 22, 2017): 6382–87. http://dx.doi.org/10.1073/pnas.1700527114.

Full text
Abstract:
The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life in the hypobaric hypoxia of high altitude. Mechanisms involving enhanced tissue oxygen delivery in comparison to Lowlander populations have been postulated to play a role in such adaptation. Whether differences in tissue oxygen utilization (i.e., metabolic adaptation) underpin this adaptation is not known, however. We sought to address this issue, applying parallel molecular, biochemical, physiological, and genetic approaches to the study of Sherpas and native Lowlanders, studied before and during exposure to hypobaric hypoxia on a gradual ascent to Mount Everest Base Camp (5,300 m). Compared with Lowlanders, Sherpas demonstrated a lower capacity for fatty acid oxidation in skeletal muscle biopsies, along with enhanced efficiency of oxygen utilization, improved muscle energetics, and protection against oxidative stress. This adaptation appeared to be related, in part, to a putatively advantageous allele for the peroxisome proliferator-activated receptor A (PPARA) gene, which was enriched in the Sherpas compared with the Lowlanders. Our findings suggest that metabolic adaptations underpin human evolution to life at high altitude, and could have an impact upon our understanding of human diseases in which hypoxia is a feature.
APA, Harvard, Vancouver, ISO, and other styles
42

Fellner, Andrzej. "Safety Case Activities in SHERPA Project." TransNav, the International Journal on Marine Navigation and Safety of Sea Transportation 14, no. 3 (2020): 631–36. http://dx.doi.org/10.12716/1001.14.03.14.

Full text
APA, Harvard, Vancouver, ISO, and other styles
43

Utama, As Shiddiq Putra, Willy Tambunan, and Lina Dianati Fathimahhayati. "Analisis Human Error pada Proses Produksi Keramik dengan Menggunakan Metode HEART dan SHERPA." Jurnal INTECH Teknik Industri Universitas Serang Raya 6, no. 1 (June 27, 2020): 12–22. http://dx.doi.org/10.30656/intech.v6i1.2114.

Full text
Abstract:
Unit Pelaksana Teknis Dinas Pusat Pengembangan Koperasi dan Usaha Kecil Menengah Kota Samarinda melakukan proses produksi untuk membantu masyarakat memenuhi kebutuhan produk tanpa harus memesan keluar pulau. UPTD P2KUKM mempunyai empat workshop, salah satunya workshop keramik, Workshop keramik memproduksi dua jenis yaitu earthenware dan stoneware. Proses produksi keramik dilakukan dengan mengandalkan tenaga manusia. Penelitian ini bertujuan mengidentifikasi human error yang terjadi pada proses produksi dan memberikan rekomendasi perbaikan untuk meminimalkan human error yang terjadi. Penelitian ini menggunakan metode SHERPA dan HEART dalam menganalisis human error yang terjadi. Metode kualitatif menggunakan SHERPA untuk mengidentifikasi human error. Metode kuantitatif dengan metode HEART untuk mengetahui nilai probabilitas terjadinya human error. Berdasarkan data yang diperoleh dengan menggunakan HTA, pada proses produksi keramik mempunyai 6 tahapan yang terbagi dalam 18 sub-pekerjaan. Analisis secara kualitatif menggunakan metode SHERPA memperoleh 18 kemungkinan error yang dapat dilakukan oleh pekerja. Berdasarkan analisis secara kuantitatif didapatkan nilai Human Error Probability (HEP) tertinggi yaitu pada sub-pekerjaan membersihkan tanah dari kotoran dengan nilai HEP sebesar 0.99. Rekomendasi perbaikan untuk mengurangi terjadinya kesalahan manusia (human error) yaitu briefing sebelum melakukan pekerjaan, membuat display, membuat form checklist, melakukan pengawasan dan training. Meminimalkan human error pada suatu proses produksi secara tidak langsung mampu meningkatkan tingkat produktivitas pekerja.
APA, Harvard, Vancouver, ISO, and other styles
44

Pyke, Rachel Marty, Steven Dea, Hima Anbunathan, Charles W. Abbott, Neeraja Ravi, Jason Harris, Gabor Bartha, et al. "Abstract 5640: Mono-allelic immunopeptidomics data from 109 MHC-I alleles reveals variability in binding preferences and improves neoantigen prediction algorithm." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5640. http://dx.doi.org/10.1158/1538-7445.am2022-5640.

Full text
Abstract:
Abstract Neoantigen-based biomarkers are a promising approach for stratifying patient response to immunotherapy; however, current neoantigen prediction methods are not accurate enough to optimize these biomarkers. Sequence variability in the major histocompatibility complex (MHC) leads to the presentation of diverse neoantigens to T cells, and accurately representing this diversity in neoantigen prediction is critical for improvement. Previously, we published data from 25 mono-allelic cell lines and built an associated MHC class I, pan-allelic neoantigen prediction algorithm (SHERPATM). Here, we profile an additional 84 MHC alleles including 37 that have never previously been profiled with mono-allelic immunopeptidomics, explore the impact of MHC variability on peptide binding and improve neoantigen prediction of the SHERPA algorithm. To generate the data, we stably and transiently transfected 109 different MHC alleles (43 HLA-A, 56 -B and 10 -C alleles) into independent K562 HLA-null cell lines, immunoprecipitated intact MHC complexes using a W6/32 antibody and profiled the bound peptides using LC/MS-MS. We recovered a median of 1430 peptides per allele, with yields from the transient transfections being consistently higher than the stable transfections. Nearly all alleles have a strong anchor residue in the ninth position, but the positions of the secondary anchor residue vary by gene. HLA-B showed a stronger preference for the second position while HLA-A exhibited more variability across the first, second and third positions. In addition to the 109 mono-allelic cell lines, SHERPA increases generalizability by systematically integrating an additional 104 mono-allelic and 384 multi-allelic samples with publicly available immunopeptidomics data. The 186 alleles in the resulting training dataset have an average allelic coverage of 98% across 18 different US-based ethnicities. We evaluated our updated performance on 10% held-out mono-allelic test data from multiple cell line sources. The positive predictive value (PPV) of SHERPA was markedly higher than either NetMHCPan 4.1 or MHCFlurry-2.0 (1.45 and 1.58-fold increase, respectively), with further gains when only the 37 previously unprofiled alleles were considered (1.51 and 1.79-fold increase, respectively). Furthermore, the SHERPA model was able to detect 1.38-fold more immunogenic epitopes than either other method. Finally, we performed predictions with SHERPA across millions of synthetic binding pockets and peptides to elucidate the impact of MHC variability on peptide diversity. We found a strong correlation between binding pocket positions that highly influence peptide binding and those that are evolutionarily divergent. In conclusion, we profiled 109 mono-allelic cell lines, showed key trends in MHC-associated peptides and improved the SHERPA neoantigen prediction model. Citation Format: Rachel Marty Pyke, Steven Dea, Hima Anbunathan, Charles W. Abbott, Neeraja Ravi, Jason Harris, Gabor Bartha, Sejal Desai, Rena McClory, John West, Michael P. Snyder, Richard O. Chen, Sean Michael Boyle. Mono-allelic immunopeptidomics data from 109 MHC-I alleles reveals variability in binding preferences and improves neoantigen prediction algorithm [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5640.
APA, Harvard, Vancouver, ISO, and other styles
45

Zetli, Sri. "Analisis Human Error dengan Pendekatan Metode SHERPA dan HEART pada Produksi Batu Bata UKM Yasin." Jurnal INTECH Teknik Industri Universitas Serang Raya 7, no. 2 (December 31, 2021): 147–56. http://dx.doi.org/10.30656/intech.v7i2.3934.

Full text
Abstract:
Kesalahan kerja yang terjadi banyak diakibatkan oleh manusia itu sendiri yang disebut dengan human error. Human error yang sering terjadi dalam kegiatan produksi bisa merugikan perusahaan dalam mewujudkan efektivitas dan efisiensi produksi. Oleh karena itu maka perlu dilakukan perbaikan performansi pekerja untuk mengurangi seringnya terjadi kesalahan kerja. Beberapa metode dalam mengidentifikasi human error diantaranya metode SHERPA dan HEART. SHERPA suatu metode kualitatif dalam menganalisis human error yang menjadikan task level sebagai dasar inputnya. Sedangkan HEART adalah metode dalam menentukan resiko human error yang cepat, sederhana dan gampang dimengerti oleh para engineers dan juga human factors specialists. UKM Yasin merupakan salah satu UKM yang bergerak dalam produksi batu bata di Kota Batam. Proses pembuatan batu bata melalui beberapa tahapan yaitu proses pencetakan, proses pengeringan dan proses pembakaran. Permasalahan yang masih sering terjadi yaitu kesalahan saat melakukan pekerjaan yang berakibat terhadap kecelakaan kerja dan juga berpengaruh terhadap output produksi batu bata, hal ini disebabkan oleh human error. Hasil penelitian untuk rekomendasi yang akan diperlukan untuk mereduksi error pada proses produksi batu bata dengan metode SHERPA yaitu melakukan pemeriksaan secara teliti dan rutin terhadap masing-masing proses dan memberikan pelatihan secara berkala terhadap pekerja. Peluang terjadinya error dalam setiap aktivitas pekerjaan pada produksi batu bata dengan menggunakan metode HEART dimana nilai human error probability yang paling besar yaitu 0.16. Proses yang mungkin terjadinya human error dalam tahapan proses produksi batu bata di UKM Yasin melalui nilai Human Error Probability (HEP) tertinggi yaitu 0.544 yang terdapat pada proses pembakaran batu bata.
APA, Harvard, Vancouver, ISO, and other styles
46

Boehm, Peter M., and Cécile Tarpinian. "De l’utilité du G7 : témoignage d'un sherpa." Politique étrangère Été, no. 2 (2019): 61. http://dx.doi.org/10.3917/pe.192.0061.

Full text
APA, Harvard, Vancouver, ISO, and other styles
47

Palmieri, Richard P. "Cattle Hybrids Among the Sherpa of Nepal." Journal of Cultural Geography 7, no. 2 (March 1987): 89–100. http://dx.doi.org/10.1080/08873638709478509.

Full text
APA, Harvard, Vancouver, ISO, and other styles
48

Cascioli, F., S. Höche, F. Krauss, P. Maierhöfer, S. Pozzorini, and F. Siegert. "Automatic one-loop calculations with Sherpa+OpenLoops." Journal of Physics: Conference Series 523 (June 6, 2014): 012058. http://dx.doi.org/10.1088/1742-6596/523/1/012058.

Full text
APA, Harvard, Vancouver, ISO, and other styles
49

Gleisberg, T., S. Hoeche, F. Krauss, A. Schaelicke, S. Schumann, and J. Winter. "SHERPA 1. , a proof-of-concept version." Journal of High Energy Physics 2004, no. 02 (February 25, 2004): 056. http://dx.doi.org/10.1088/1126-6708/2004/02/056.

Full text
APA, Harvard, Vancouver, ISO, and other styles
50

Caspermeyer, J. "Examining the Source behind Sherpa Mountain Fitness." Molecular Biology and Evolution 30, no. 12 (October 22, 2013): 2735. http://dx.doi.org/10.1093/molbev/mst161.

Full text
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography