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Prysjazhnjuk, V. "Паростки лікувальної справи тварин в Галичині." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 19, no. 77 (March 7, 2017): 158–61. http://dx.doi.org/10.15421/nvlvet7734.
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Folk veterinary medicine – an important plot of national experience, which includes rational knowledge and practical skills of domestic animals treatment. The special attention was paid to those Ukrainian animals from whom was depended the success of farming (horses, cattle, pigs, sheep). In traditional veterinary medicine are mainly used the same means as in folk medicine. The most popular were the drugs of plant origin. Frequently herbal medicine is used in combination with minerals, animal fats. Folk veterinary accumulated and some knowledge about the importance of sanitation and hygiene for the successful care for domestic animals. To prevent diseases animals were kept in damp or cold places, did not allow to drink stagnant water, periodically changed grazing and watering place, followed by timely horses forging and oxen. During the wars there were observed various wounds in horses, applied with edged weapons, slaughter, stretching, injuries and more. Those wounds were treated by horsemen, using methods and traditional medicines. For bandaging the injured limb, as well as the blood stops substances are used dry and pre-boiled wool, rough canvas, tar, ash, various drugs and other means. After the end of hostilities the treatment of injuries in horses were engaged healers, chiropractors, but mostly – horse doctor, paying particular attention to the full feed, care of the skin, hooves. The shepherd had known about infectious diseases, which they tried to prevent and treat, and diseases of the udder, digestive and respiratory system. The shepherds tried in various ways to treat and parasitic diseases. For example, Fasciolosis (rot) they treated with fir branches, hemp seed, toasted oats. Shepherds, herdsmen, healers collected, dried, stored and used medicinal herbs during genera and injuries, they were also engaged in bloodletting. For therapeutic purposes blood fat, bile, bone marrow, milk and dairy products, vegetable oils were used, to wit they were the first veterinary specialists doctors. Itinerant surgeons-barbers were also engaged in treatment of animals. In the twelfth century. surgeons-barbers moved to sedentary lifestyles and became to join into craft, which were engaged in the treatment of sick animals and training of young professionals. Barbers surgeons played great role in life and everyday life of the Lviv philistinism. They were engaged in treatment, produced drugs, patches, bled and also sheared and shaved.
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Rajapaksa, Suresh, David McIntosh, Allison Cowin, Damian Adams, and Peter-John Wormald. "The Effect of Insulin-Like Growth Factor 1 Incorporated into a Hyaluronic Acid-Based Nasal Pack on Nasal Mucosal Healing in a Healthy Sheep Model and a Sheep Model of Chronic Sinusitis." American Journal of Rhinology 19, no. 3 (May 2005): 251–56. http://dx.doi.org/10.1177/194589240501900307.
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Background Endoscopic sinus surgery (ESS) is the accepted surgical treatment for chronic refractory rhinosinusitis. Prolonged healing and adhesion formation remain common problems. This study investigates the use of a hyaluronic acid-based pack impregnated with insulin-like growth factor (IGF) 1 to facilitate more rapid and effective healing after ESS in a healthy sheep model and a sheep model of chronic sinusitis. Methods This study used 12 healthy sheep and 9 sheep with chronic sinusitis. In each sheep one side (computer randomized) was used as a control. Under endoscopic guidance, mucosal injuries and adhesions were created on both sides and were either packed with a hyaluronic acid pack impregnated with IGF-1 or left unpacked as a control. Serial biopsies were performed for 4 months. Results In the healthy sheep there was a statistically significant (p < 0.05) improvement in reepithelialization in IGF-1 packed wounds at day 28 (89% for IGF-1 versus 44% for controls). In both healthy sheep and sheep with sinusitis there was no significant difference in mucosal reepithelialization at any of the other measured time points. In the sinusitis group, there was a significant decrease in ciliary regeneration at day 56 in the Merogel/IGF-1 group compared with the control group: 59.20% versus 77.68% (p < 0.01) and at day 112, 69.70% versus 87.26% (p < 0.01). Conclusion Hyaluronic acid impregnated with IGF-1 improved reepithelialization in the healthy sheep but not in the sheep with chronic rhinosinusitis. These packs had a detrimental effect on mucosal ciliary regeneration in the sheep with chronic rhinosinusitis.
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Kaufman, Howard H. "Treatment of head injuries in the American Civil War." Journal of Neurosurgery 78, no. 5 (May 1993): 838–45. http://dx.doi.org/10.3171/jns.1993.78.5.0838.
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✓ At the time of the American Civil War (1861–1865), a great deal was known about closed head injury and gunshot wounds to the head. Compression was differentiated from concussion, but localization of lesions was not precise. Ether and especially chloroform were used to provide anesthesia. Failure to understand how to prevent infection discouraged physicians from aggressive surgery. Manuals written to educate inexperienced doctors at the onset of the war provide an overview of the advice given by senior surgeons. The Union experiences in the treatment of head injury in the Civil War were discussed in the three surgical volumes of The Medical and Surgical History of the War of the Rebellion. Wounds were divided into incised and puncture wounds, blunt injuries, and gunshot wounds, which were analyzed separately. Because the patients were not stratified by severity of injury and because there was no neuroimaging, it is difficult to understand the clinical problems and the effectiveness of surgery. Almost immediately after the war, increased knowledge about cerebral localization and the development of antisepsis (and then asepsis) permitted the development of modern neurosurgery.
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Newlands, Shawn D., Sreedhar Samudrala, and W. Kevin Katzenmeyer. "Surgical Treatment of Gunshot Injuries to the Mandible." Otolaryngology–Head and Neck Surgery 129, no. 3 (September 2003): 239–44. http://dx.doi.org/10.1016/s0194-5998(03)00481-9.
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OBJECTIVES: Our goal was to review and identify risk factors for complications from treatment of mandible fractures due to gunshot wounds. STUDY DESIGN AND SETTING: We conducted a retrospective review of treatment outcomes in 90 patients with gunshot wounds to the mandible treated over a 10-year period at 2 tertiary care centers. RESULTS: Our series of 90 patients with mandibular injuries due to gunshot wounds included 68 patients who underwent surgical procedures on the mandible. There were 14 complications in this group. Complications were more common in patients whose mandibles were rigidly fixated; however, these patients' injuries were more severe. Complications were significantly increased in patients who lost a segment of mandible in the injury. CONCLUSIONS: Complications were related to severity of injury and independent of treatment modality. SIGNIFICANCE: The complication rate for patients with gunshot injuries can be very high, particularly if bone is missing. Stabilization of remaining mandibular segments with potentially multiple subsequent reconstructive procedures is often required to restore mandibular continuity in these patients.
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Chierice, João, Geraldo Figueiredo, Moyses Lima-Filho, Igo Lago, Rodrigo Costa, and José Marin-Neto. "Hybrid interventional and surgical treatment of complex traumatic cardiac dagger wounds." Journal of Transcatheter Interventions 29 (July 1, 2021): 1–5. http://dx.doi.org/10.31160/jotci202129a20210008.
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Penetrating injuries to the heart are usually devastating and few patients survive the initial trauma. The most frequent penetrating injuries are caused by projectile injuries and less commonly by melee weapons. Most of these injuries involve chamber free walls and a small percentage can affect the interventricular septum. We report a case in which an emergency surgical procedure was successful in controlling cardiac tamponade, and repairing a right ventricular laceration caused by multiple stab wounds. Subsequently, a successful interventional occlusion of a large interventricular septal defect, associated with significantly augmented pulmonary flow was performed.
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Lepp??niemi, Ari K., and Norman M. Rich. "Treatment of Vascular Injuries in War Wounds of the Extremities." Techniques in Orthopaedics 10, no. 3 (1995): 265–71. http://dx.doi.org/10.1097/00013611-199501030-00019.
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Amarantov, D. G., M. F. Zarivchatskii, A. A. Kholodar, O. S. Gudkov, and E. V. Kolyshova. "Modern approaches to surgical treatment of thoraco-abdominal wounds." VESTNIK KHIRURGII IMENI I.I.GREKOVA 177, no. 5 (November 23, 2018): 100–104. http://dx.doi.org/10.24884/0042-4625-2018-177-5-100-104.
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Thoraco-abdominal wounds are the most severe injuries of the chest and abdomen, with mortality reaching 13–20 %. The main focus of treatment of such patients is surgical correction of the injuries. Wide range of classical and minimally invasive interventions is used for treatment of victims . The paper presents the range of views of modern researchers on the indications for laparocentesis, drainage of the pleural cavity, thoracoscopy and laparoscopy, thoracotomy and laparotomy in this pathology. The opinions of various researchers on the optimal combination of interventions and tactics of surgical treatment of victims with thoraco-abdominal wounds are presented. It is necessary to continue the search for optimal combinations of classical and minimally invasive interventions in relation to a variety of clinic situations that arise in the treatment of patients with thoraco-abdominal wounds.
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Trukhan, A. P., D. V. Alkhovik, I. G. Kosinsky, V. A. Koryachkin, V. A. Porkhanov, and I. Yu Zherkal. "REPUBLICAN CENTER FOR TREATMENT OF GUNSHOT WOUNDS AND MINE-EXPLOSIVE INJURIES: 3 YEARS OF EXPERIENCE AND TRENDS OF DEVELOPMENT." Novosti Khirurgii 29, no. 2 (April 21, 2021): 207–12. http://dx.doi.org/10.18484/2305-0047.2021.2.207.
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Objective. To evaluate the results of organizational measures for improving the efficiency of the Republican Center for the treatment of gunshot wounds and mine-explosive injuries. Methods. The study is based on an analysis of the work of the Republican Center for the treatment of gunshot wounds and mine-explosive injuries and includes patients (n=54) who were treated from November 1, 2016 to October 31, 2019. Gunshot wounds were detected in 42 patients (77.8%). Explosive trauma was detected in 12 patients (22.2%). The most common causes of injuries were personal carelessness (20 cases (37.0%)), carelessness of others (16 cases (29.6%)), suicidal attempts (9 cases (16.6%)). In accordance with the purpose of the survey, three equal time intervals (three periods) each being equal to one year were studied. The following indicators were analyzed: the number of patients, the time from the moment of injuring to hospitalization, the type of patient’s transportation, the quality of surgical care at the hospitalization stages. Results. Implementation of the proposed organizational measures allowed increasing the number of patients hospitalized into the Republican Center for the treatment of gunshot wounds and mine-explosive injuries during the third year of work by 66.7% and 78.6%, respectively, compared with the previous time intervals. The frequency of hospitalization of patients within 24 hours after receiving an injury increased from 66.7% to 72.7%, and among patients who are not military personnel - from 45.5% to 69.2%. The proportion of errors in the treatment of patients with gunshot wounds and explosive injuries decreased by 34.0%. Conclusion. The proposed organizational measures allowed increasing the efficiency of the Republican Center for the treatment of gunshot wounds and mine-explosive injuries. In the future, it is advisable to continue close cooperation with healthcare organizations and to improve the regulatory framework for the treatment of gunshot wounds of various localization. What this paper adds The paper presents the results of the analysis of three-year work of the RepublicanCenter for the treatment of gunshot wounds and mine-explosive injuries.Realization of the proposed organizational measures allowed increasing the number of hospitalized patients, shortening the period from injury to hospitalization, and reducing the number of errors in patient care.
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Jalili, Reza, Myriam Maude Verly, Breshell Russ, Ruhangiz T. Kilani, and Aziz Ghahary. "645 Topical Application of a Novel Powdered Scaffold for Rapid Treatment of Skin Injuries." Journal of Burn Care & Research 41, Supplement_1 (March 2020): S168—S169. http://dx.doi.org/10.1093/jbcr/iraa024.265.
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Abstract Introduction In large skin injuries, lack of matrix deposition impedes timely healing process. The longer a wound remains open, the greater is the risk of infection, non-healing, and other complications. It is therefore crucial to find effective means to promote rapid closure of skin defects. Our group has previously developed a liquid in situ-forming nutritional scaffold, known as MeshFill (MF). MF has been previously proven to be very effective in accelerating the wound repair process, notably that of complex wounds. However, MF is limited in its application to deep and tunnelling wounds, and requires reconstitution with a solvent as well as maintenance at cold temperature until application. To address these limitations, our group has developed a powdered form of MF for rapid topical application on superficial skin injuries such as dehisced surgical wounds and burn injuries. Methods Our goal was to investigate whether a powdered form of MF could be directly applied onto the wounds to accelerate healing. Ideally, powdered MF would absorb the moisture within the wound environment and reconstitute into the gel form in situ. We examined the efficacy of powder MF (PMF) compared to reconstituted gel MF (GMF) and to a standard dressing protocol. To do so, splinted full thickness wounds were generated on the back of mice and treated with either PMF or GMF or were bandaged with no treatment (NT). The healing process was monitored until wounds were fully closed. Clinical wound measurements and histological assessments were performed to compare different treatment regimens. Results Application of both PMF and GMF accelerated wound epithelialization at days 7 and 14, compared to NT, and had faster wound closure times. On average, the PMF treatments healed 17% faster than the NT control, and the GMF treatments healed 21% faster than the NT control. No significant difference between PMF and GMF was found for any outcomes. Additionally, our results suggest that epidermis formation was more effective in P and MF conditions compared to NT. Conclusions These findings suggest that topical application of a powdered form of MeshFill is as effective as standard reconstituted MeshFill gel in accelerating the healing process of skin injuries. Applicability of Research to Practice Topical application of a powdered scaffold may be a very convenient and practical method for rapid treatment of large superficial wounds such as dehisced surgical wounds, burn injuries, and filling gaps in meshed skin grafts.
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Sizyi, M. Yu. "Septic complications in patients with neck wounds." Експериментальна і клінічна медицина 84, no. 3 (August 21, 2020): 64–66. http://dx.doi.org/10.35339/ekm.2019.84.03.10.
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Nowadays, we have been a steady increase in injuries as the social conditions of life and have changed. Statistically found that 54.0 % of people of car accidents have injuries to the head and neck. According to the literature, mortality in patients with neck injury which is complicating by pyoinflammatory persists up to 30.0-76.0 %. The management of neck trauma can be challenging and sometimes overwhelming, as this anatomical region contains many vital structures. These structures may pose a diagnostic and therapeutic dilemma. Our research based on the results of diagnosis and treatment of 124 patients with a purulent mediastinitis, complicating traumatic injuries of the neck organs. Among these men – 92 (74.2 %), women – 32 (25.8 %). The results of treatment depend on timely diagnosis, hospitalization in a specialized compartment and conducting active surgical tactics
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Stekolnikov, A. A., and M. A. Ladanova. "TECHNOLOGICAL INJURIES IN INDUSTRIAL PIG FARMING." International bulletin of Veterinary Medicine 1 (2020): 135–39. http://dx.doi.org/10.17238/issn2072-2419.2020.1.135.
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Industrial injuries in pig farms of closed type are a very common pathology. Howev-er, nowadays, injury prevention and treat-ment of sick animals in the conditions of industrial pig breeding complex do not bring good results and require improvements. Ac-cording to the literature, there is no infor-mation about the results of the use of oint-ments and immuno- stimulators in the treat-ment of pigs with bitten wounds of the ears, tails and other parts of the body. In this re-gard, we have set a goal to develop therapeu-tic measures for injuries of piglets in a pig breeding complex of a closed type. We ana-lyzed the prevalence of industrial injuries in pigs. During the clinical examination, we studied the specific structures of injuries. The main cause of pigs injuries in industrial farming is cannibalism. In 28 days, 60% of pigs in the second experimental group, showed complete cicatrization of the wound, and 40% of animals showed this process regenerated on 85-95%, meanwhile 2 days they also had complete scarring of the wound. In 28 days, 50% of pigs of the third experimental group had a complete cicatriza-tion of the wound, and for 50% were ob-served scarring of the wound by 75-85%, and only after 4 days they demonstrated the complete scaring of the defect. For the treatment of bitten wounds as a result of developing cannibalism, it is recommended, to use local treatment of wounds with chlor-hexidine solution and argosulfan ointment daily 2 times a day and also to use the im-munostimulator “Ferrovir” in a dose of 1.0 ml/m2 per week. Such scheme of treatment of bitten wounds gives the best therapeutic effect.
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Mitkovic, Milorad, Marko Bumbasirevic, Sasa Milenkovic, Ivan Micic, Predrag Stojiljkovic, Igor Kostic, Sasa Karalejic, et al. "Nature and results of treatment of war wounds caused by cluster bombs." Acta chirurgica Iugoslavica 60, no. 2 (2013): 41–47. http://dx.doi.org/10.2298/aci1302041m.
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The aim of this study is to describe the nature of war wounds with fracture caused by cluster bombs and to suggest treatment options for such injuries. The nature of wounds caused by cluster bombs differs from those caused by conventional arms (they are more severe). The sides of the wounds are represented by conquasated soft tissues (such as fat and muscle) with thick dead tissues, ordinarily with a thickness of 0.5-4.5 cm. Another main characteristic of such injuries is the high percentage of amputations needed due to the high rate of neurovascular damage. This paper investigates the cases of 81 patients who sustained a total of 99 war wounds with fractures. The average age of the patients was 32.7 years while the youngest was 20 and the oldest, 77. According to The International Committee of the Red Cross (ICRC) classification of war wounds, 14 patients had grade I injuries, 48 patients grade II, and 29 patients, grade III. Mitkovic external fixation system, known also as the "War Fixator" was used for all fractures fixation. One protocol, which was a modification of the ICRC?s protocol adapted to our specific conditions, was used throughout the study. For solving soft tissue defects, a rotator fasciocutan flap was the most frequently used. For solving of bones defect Mitkovic reconstructive external fixation device was used. All fractures we treated healed. We concluded that shortening the procedural time and being a very simple, immediate using of Mitkovic versatile external fixator ("War Fixator") is , leads to desirable results.
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Draper, David O., Kenneth L. Knight, and Justin H. Rigby. "High-Volt Pulsed Current: Treatment of Skin Wounds and Musculoskeletal Injuries." International Journal of Athletic Therapy and Training 17, no. 4 (July 2012): 32–34. http://dx.doi.org/10.1123/ijatt.17.4.32.
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Kornilova, A. F., and S. M. Makarova. "Prevention and modern methods of treatment of perforated eye wounds." Kazan medical journal 66, no. 2 (April 15, 1985): 94–98. http://dx.doi.org/10.17816/kazmj60730.
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Analysis of the causes of injuries at one of the factories in Saratov showed that in 92% of cases they depend on unclear instructions on safe work at the workplace, insufficient provision of work glasses of rational design.
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Tsymbaliuk, Vitalii I., Sergii S. Strafun, Ihor B. Tretyak, Iaroslav V. Tsymbaliuk, Alexander A. Gatskiy, Yuliia V. Tsymbaliuk, and Mykhailo M. Tatarchuk. "SURGICAL TREATMENT OF PERIPHERAL NERVES COMBAT WOUNDS OF THE EXTREMITIES." Wiadomości Lekarskie 74, no. 3 (2021): 619–24. http://dx.doi.org/10.36740/wlek202103210.
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The aim: Improving the effectiveness of patients' treatment with combat injuries of the peripheral nervous system, which consists in the application and development of new methods of reconstructive interventions, optimizing a set of therapeutic and diagnostic measures for the most effective management of this category of patients with peripheral nerve injury. Materials and methods: The research is based on the results of surgical treatment of 138 patients with combat injuries of peripheral nerves for the period from 2014 to 2020. The mean age was 33.5 ± 2.1 years. Patients were treated for 1 to 11 months after injury (median – 8 months). Damage to the sciatic nerve was observed in 26.1%, ulnar – in 20.3%, median – in 18.8%, radial – in 15.9%, tibial – in 10.9%, common peroneal nerve – in 8% of cases. Results: It was shown that in all patients was significantly improved the recovery of all nerves. In the period from 9 to 12 months, the degree of recovery of motor function to M0-M2 was observed in 40.6%, to M3 – in 35.5%, to M4 – in 16.7%, to M5 – in 7,2%. The degree of recovery of sensitivity to S0-S2 was observed in 36.2%, to S3 – in 42.8%, to S4 – in 17.4%, to S5 – in 3.6%. Regression of pain syndrome after surgery was observed in 81.2% of patients. Conclusions: The results of surgical treatment of peripheral nerves gunshot injury are generally worse than other types of nerve injuries. The best results of surgical treatment of combat trauma of peripheral nerves are obtained in patients with sciatic nerve damage.
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ANGERMANN, P., and M. LOHMANN. "Injuries to the Hand and Wrist. A Study of 50,272 Injuries." Journal of Hand Surgery 18, no. 5 (October 1993): 642–44. http://dx.doi.org/10.1016/0266-7681(93)90024-a.
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This study reports the causes, characteristics and treatment of injuries to the hand and wrist presented to five accident and emergency departments in a 2-year survey of 13% of the Danish population. The rate of injury to the hand or wrist was 28.6% of all injuries, or 3.7 per 100,000 inhabitants per year. 34% of the accidents were domestic, 35% were leisure accidents, 26% were occupational and 5% were traffic accidents. Only 2% of the patients were admitted to hospital for further treatment or observation and 13% were referred to a hospital as outpatients. The most frequent causes for admission were fractures (42%), tendon lesions (29%) and wounds (12%).
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Kočišová, A., J. Pistl, R. Link, E. Čonková, and M. Goldová. "Maggot Debridement Therapy in the Treatment of Footrot and Foot Scald in Sheep." Acta Veterinaria Brno 75, no. 2 (2006): 277–81. http://dx.doi.org/10.2754/avb200675020277.
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In sheep with acute and chronic interdigital skin inflammation, maggot therapy was used for the debridement and speeding up the healing process. Sheep were housed at the university farm Zemplínska Teplica and before using maggot therapy, they were unsuccessfully treated by a footbath containing 10% copper sulphate and topical application of oxytetracycline solution in alcohol. Six non-pregnant Valachian sheep between two to four years of age, weighing 43 to 57 kg were treated with maggots of Lucilia sericata (Meigen) (Diptera: Calliphoridae). The larval population should be 8-12 per square centimetre of wound, but all affected tissues were trimmed away before their application. The effect of a single application for 3-6 days was evaluated. Debridement was rapid and selective. The treatment was well tolerated by animals. New layers of healthy tissue were formed over the wounds. It was observed that maggots of L. sericata are capable of cleaning the wounds after single application.
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Bajec, Djordje, Dejan Radenkovic, Pavle Gregoric, Vasilije Jeremic, Vladimir Djukic, Nenad Ivancevic, Borivoje Karadzic, et al. "Hirursko lecenje povreda jetre - petogodisnje iskustvo." Acta chirurgica Iugoslavica 57, no. 4 (2010): 9–14. http://dx.doi.org/10.2298/aci1004009b.
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Due to improved methods of treatment and management of hemorrhage, the mortality from liver injuries has decreased significantly over the past few decades. In spite of that, liver injuries still represent diagnostic and therapeutic challenge. This retrospective study included 197 patients surgically treated because of trauma of the liver at The Clinic for Emergency Surgery, during the period 2004-2009. The results showed significant difference in mortality rates in cases of penetrating wounds compared to blunt trauma and gunshot wounds. The severity of injury evaluated by Organ Injury Scale was significantly higher in gunshot wounds compared to blunt and penetrating trauma. The correlation of severity of injuries and mortality rates showed that the mortality is significantly lower in patients with grade 1, 2, and 3 injuries compared to grades 4 and 5 (p=0.016). Specific complication rate was 28.4%, while mortality rate was 21.8%. The results reflect diagnostic and treatment problems, as well as the importance of multidisciplinary approach to the patients with liver trauma.
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Cole, Roger D., J. Dale Browne, and C. David Phipps. "Gunshot Wounds to the Mandible and Midface: Evaluation, Treatment, and Avoidance of Complications." Otolaryngology–Head and Neck Surgery 111, no. 6 (December 1994): 739–45. http://dx.doi.org/10.1177/019459989411100607.
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As American society becomes progressively violent, an ever-increasing number of gunshot wounds are being seen across the United States. Particularly challenging are injuries that involve the mandible and midface, not only because of problems with reconstructing bone and soft-tissue defects but also because of emergent problems with airway obstruction and neurovascular compromise. We present 40 cases of gunshot wounds to the mouth, mandible, and maxilla treated at Wake Forest University Medical Center during the past 7 years. The focus of this retrospective analysis is on emergency evaluation and treatment, complications encountered, and operative techniques used for reconstruction. Special emphasis is placed on recognizing and avoiding the complications of these injuries.
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Dhupa, S., and J. E. Harris. "Treatment of degloving injuries with autogenous full thickness mesh scrotal free grafts." Veterinary and Comparative Orthopaedics and Traumatology 21, no. 04 (2008): 378–81. http://dx.doi.org/10.3415/vcot-07-04-0029.
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SummaryIn this report, we evaluated the effectiveness of scrotal tissue as an autogenous free skin graft to treat cutaneous degloving injuries of the distal limb in dogs. Surgery was performed on two male intact dogs with distal extremity degloving wounds. Dog #1 had a tarsal degloving wound with exposure of the distal tibial and tarsal bones. Dog #2 had a degloving injury over the metacarpals. Wounds were treated with daily wetto- dry bandages in order to develop a healthy bed of granulation tissue at the graft recipient site. Scrotal ablation castration was performed once the recipient site had been prepared. Subcutaneous and adipose tissue were excised from the scrotal graft and mesh slits were created. The graft was applied to the recipient site with monofilament absorbable simple interrupted sutures. Bandaging was performed postoperatively, and bandage changes occurred four, seven, nine and 11 days postoperatively. Follow-up was performed at 30 days. In dog #1, the tarsal degloving injury graft had first intention healing with 100% graft take on day 11. In dog #2, the metacarpal degloving injury graft had 90% graft take on day nine, with second intention healing adjacent to the fifth digit pad. The scrotum is often discarded at the time of scrotal ablation castration. Distal extremity wounds can be successfully treated with free skin grafts. In male dogs, the scrotum is a viable option as a full thickness mesh free graft for distal extremity reconstructive surgery.
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Hanazono, Yutaka, Hiroaki Shibata, Naohide Ageyama, Yujiro Tanaka, Yukiko Kishi, Shinichiro Nakamura, Kyoko Sasaki, Satoshi Hayashi, Yoshihiro Kitano, and Keiji Terao. "Prevention of Tumor Formation after Allogeneic In Utero Transplantation of Cynomolgus Monkey Embryonic Stem Cell-Derived Hematopoietic Precursors." Blood 106, no. 11 (November 16, 2005): 189. http://dx.doi.org/10.1182/blood.v106.11.189.189.
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Abstract Although human ES cell-based transplantation therapies would hold a great potential in the treatment of a variety of diseases and injuries, there is a concern for teratoma formation after transplantation. In this study, we assessed the risk of tumor formation during the hematopoietic engraftment derived from cynomolgus ES cells (cyESCs) in an allogeneic transplantation model. cyESCs expressing GFP were cultured on OP9 stromal cells and induced to differentiate into the putative hematopoietic precursors. According to the flow cytometric analysis, CD34 was up-regulated on day 6 but decreased thereafter. Notably, CD31, CD144 (VE-cadherin) and VEGFR-2 (Flk-1) were all up-regulated on day 6. These are key markers of hemangioblasts (which generate endothelial and hematopoietic lineages). Despite the hemangioblast marker expression on day 6, the SCL gene was up-regulated at this time point as assessed by RNA-PCR, implying that the hematopoietic commitment might have already occurred on day 6. CD45, however, was not detected until day 12. The day-6 cells were transplanted in utero into allogeneic (cynomolgus) preimmune fetuses (n = 3) in the liver under ultrasound guidance around the end of first trimester (49–66 days/full term 165 days). We transplanted day-6 cells because the CD34 expression was the highest at this time point. We transplanted the cells into the liver because the liver is the major hematopoietic organ at these gestation days. Fetuses were delivered at 3 months after transplantation (almost at full term). The transplanted cell-derived, GFP-positive hematopoietic colony-forming cells were successfully detected in the newborns (4–5%). Hematopoietic engraftment from cyESCs was thus achieved albeit at low levels. However, teratomas formed in all the three newborns. They were derived from transplanted cells, because they expressed GFP. The risk of tumor formation was unexpectedly high, given that we had seldom observed tumor formation in immunodeficient mice or fetal sheep that had been transplanted with the same day-6 cyESC-derivatives. Innate immune responses against cynomolgus-derived tumors might be more rigorous in xeno-transplanted mice and sheep than in allo-transplanted monkeys, resulting in failure to detect tumorigenesis in the xeno-transplantation models. Our monkey allogeneic transplantation setting would therefore allow the strict evaluation of in vivo safety of transplantation therapies using ES cells. It turned out that day-6 cyESC-derivatives included residual SSEA-4-positive pluripotent cells (38.2 ± 10.3%) despite the rigorous differentiation culture. Presumably those cells were responsible for the teratoma formation. We purged an SSEA-4-positive fraction of day-6 cyESC-derivatives using a cell sorter and transplanted the negative fraction into the fetal liver (n = 6). At delivery, tumors were no longer observed in all the six animals, while the cyESC-derived hematopoietic engraftment was unperturbed (2–5%). SSEA-4 is therefore a clinically-relevant pluripotency marker of primate ES cells. Purging cells with this surface marker would be a promising method for clinical progenitor cell preparations using human ES cells.
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Yamamoto, Ryo, Mark Muir, and Alicia Logue. "Colon Trauma: Evidence-Based Practices." Clinics in Colon and Rectal Surgery 31, no. 01 (December 19, 2017): 011–16. http://dx.doi.org/10.1055/s-0037-1602175.
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AbstractColon injury is not uncommon and occurs in about a half of patients with penetrating hollow viscus injuries. Despite major advances in the operative management of penetrating colon wounds, there remains discussion regarding the appropriate treatment of destructive colon injuries, with a significant amount of scientific evidence supporting segmental resection with primary anastomosis in most patients without comorbidities or large transfusion requirement. Although literature is sparse concerning the management of blunt colon injuries, some studies have shown operative decision based on an algorithm originally defined for penetrating wounds should be considered in blunt colon injuries. The optimal management of colonic injuries in patients requiring damage control surgery (DCS) also remains controversial. Studies have recently reported that there is no increased risk compared with patients treated without DCS if fascial closure is completed on the first reoperation, or that a management algorithm for penetrating colon wounds is probably efficacious for colon injuries in the setting of DCS as well.
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Jha, Shilpa, Wasim S. Khan, and Nashat A. Siddiqui. "Mammalian Bite Injuries to the Hand and Their Management." Open Orthopaedics Journal 8, no. 1 (June 27, 2014): 194–98. http://dx.doi.org/10.2174/1874325001408010194.
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Bite wounds are a common form of hand injury with the potential to lead to severe local and systemic sequelae and permanent functional impairment. Mammalian bite wounds may be caused by a variety of animal class and species; injuries resulting from dogs, cats and humans are the most widely discussed and reported in the literature. Bite wounds may be contaminated with aggressive pathogens and the anatomical vulnerability of structures within the hand means that without early recognition and treatment with irrigation and antibiotics, alongside a low index of suspicion for deep structural involvement requiring formal surgical exploration and washout, the consequences of such injuries can be disastrous. We review the literature and discuss the epidemiology, pathophysiology and microbiology relating to these injuries, as well as clinical aspects including signs, symptoms, and management.
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Lentscher, Jessica A., Joshua C. Combs, Karrie Walker, Christopher M. Young, and Rebecca Chason. "Postdeployment Fertility Challenges and Treatment in the Modern Era." Seminars in Reproductive Medicine 37, no. 05/06 (September 2019): 239–45. http://dx.doi.org/10.1055/s-0040-1713430.
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AbstractCurrent war-fighting environments have shifted dramatically over the past decade, and with this change, new types of injuries are afflicting American soldiers. Operative Enduring Freedom and Operation Iraqi Freedom have noted an increased use of sophisticated improvised explosive devices by adversaries. Injuries not frequently seen in previous conflict are dismounted complex blast injuries, which involve multiple proximal amputations, pelvic fractures, and extensive perineal wounds. Thus, an unforeseen consequence of the decreased mortality rate after these complex blast injuries is a new wave of U.S. service members facing the challenges of recovering from the catastrophic amputations and genitourinary injuries. New applications of sperm retrieval methods may be used in these specific populations, as they recover and wish to purse family-building goals. Spinal cord injuries, traumatic brain injuries, and considerations unique to the female soldier are explored in this review of urologic care in wounded veterans.
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de Wind, Christina M. "Severe Infections following Fish Bone and Spine Injuries." Tropical Doctor 26, no. 4 (October 1996): 168–69. http://dx.doi.org/10.1177/004947559602600410.
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Injuries by fish bones and spines can cause severe infections and tissue necrosis, more extensive than one would expect in such small wounds. This paper describes the injuries and the treatment of 25 patients.
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Syzyi, M. Yu. "URGICAL TACTICS IN WOUNDS OF PHARYNX AND CERVICAL ESOPHAGUS." Kharkiv Surgical School, no. 5-6 (December 25, 2019): 95–98. http://dx.doi.org/10.37699/2308-7005.5-6.2019.20.
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Summary. The results of surgical treatment of 98 patients with penetrating injuries to the pharynx and cervical esophagus are presented. The patients were divided into the main and the comparison group. In the comparison group, the traditional principles of intervention were used. In the main group, surgical intervention was performed with a mini access on the neck 3-4 cm in length using a ring-shaped retractor. In the main group there was a twofold decrease in the frequency of purulent complications after surgical treatment of penetrating injuries to the pharynx and cervical esophagus, in comparison with the comparison group.
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Kotiv, B. N., I. M. Samokhvalov, V. Yu Markevich, A. P. Chuprina, I. I. Dzidzava, O. V. Barinov, V. V. Suvorov, A. V. Goncharov, A. A. Rud, and K. V. Petukhov. "Prevention and treatment of infectious complications of penetrating thoracic injuries." Bulletin of the Russian Military Medical Academy 20, no. 4 (December 15, 2018): 22–25. http://dx.doi.org/10.17816/brmma12240.
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Results of treatment of 325 wounded are analyzed with penetrating wounds of the chest and identify risk factors for the development of infectious complications. Found that infectious complications of the chest organs developed in 49 (15,1%) cases. It has been established that the most frequent infectious complications of penetrating wounds of the chest are post-traumatic pneumonia (67,3% of cases) and acute empyema of the pleura (26,5% of cases). The most prognostic significant risk factors for the development of infectious complications were identified: the type of injury (odds ratio - 2,48;95% confidence interval - 1,34-3,76), the severity of injuries (odds ratio - 7,88; 95% confidence interval - 3,9-15,92), blood loss (odds ratio - 3,09; 95% confidence interval - 1,6-5,94), duration of stay in the intensive care unit (odds ratio - 9,25;95% confidence interval - 4,57-18, 74), the intersection of chest wall structures (odds ratio - 2,84; 95% confidence interval- 1,24-6,47). Measures aimed at the prevention of infectious complications should be started from the moment the woundedperson enters the hospital. The priority tasks are to maintain the patency of the tracheobronchial tree, expanding the lung,adequate drainage and debridement of the pleural cavity. A high risk of developing infectious complications in penetratingwounds of the chest is expected in the wounded in a severe and extremely serious condition (according to the scale of fieldsurgery - condition at admission more than 31 points). The duration of stay in the intensive care unit for more than 4 daysincreases the probability of infectious complications 9 times.
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Syzyi, M. Yu. "TREATMENT-DIAGNOSTIC MEASURES FOR INJURY OF THE NECK." Kharkiv Surgical School, no. 3-4 (December 20, 2019): 123–25. http://dx.doi.org/10.37699/2308-7005.3-4.2019.28.
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Summary. The article is devoted to the study of the urgent problem of neck injury and medical diagnostic tactics. Externally, a small wound on the neck can hide serious damage to deep structures and adjacent anatomical areas. In peacetime during neck injuries, it is necessary stick to the basic principles of surgery: all wounds are subject to primary surgical treatment with a thorough revision of the wound canal. The algorithm of therapeutic and diagnostic measures depends on the nature and severity of the damage, clinical symptoms, and related injuries that are life-threatening.
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Zarutskii, Yaroslav, S. A. Aslanyan, I. B. Plis, A. O. Kompaniiets, and V. S. Goncharuk. "Application of NPWT in the surgical treatment of wounds and injuries of various locations - case series." Negative Pressure Wound Therapy Journal 5, no. 3 (September 28, 2018): 10. http://dx.doi.org/10.18487/npwtj.v5i3.44.
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In the modern world, local military conflicts are not uncommon. A feature of local wars is a dynamically changing tactical situation, which can lead to massive losses and more serious injuries. This creates new challenges related to the treatment of combat trauma victims. We analyzed our experience of application of NPWT in complex surgical treatment of combat wounds and injuries of various locations.
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Syre, Peter, Leonardo Rodriguez-Cruz, Rajiv Desai, Karl A. Greene, Robert Hurst, James Schuster, Neil R. Malhotra, and Paul Marcotte. "Civilian gunshot wounds to the atlantoaxial spine: a report of 10 cases treated using a multidisciplinary approach." Journal of Neurosurgery: Spine 19, no. 6 (December 2013): 759–66. http://dx.doi.org/10.3171/2013.8.spine12907.
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Object Gunshot wounds to the atlantoaxial spine are uncommon injuries and rarely require treatment, as a bullet traversing this segment often results in a fatal injury. Additionally, these injuries are typically biomechanically stable. The authors report a series of 10 patients with gunshot wounds involving the lateral mass and/or bodies of the atlantoaxial complex. Their care is discussed and conclusions are drawn from these cases to identify the optimal treatment for these injuries. Methods A retrospective review was conducted of patients presenting to the emergency rooms of 3 institutions with gunshot wounds involving the atlantoaxial spine. Mechanism of injury and neurological status were obtained, as was the extent of the osteoligamentous, vascular, and neurological injuries. Nonoperative and operative treatment, complications, and clinical and radiographic outcome were recorded. The data were then analyzed to determine the neurological and biomechanical prognosis of these injuries, the utility of the various diagnostic modalities in the acute management of the injuries, and the nature and effectiveness of the nonoperative and operative treatment modalities. Results Ten patients with gunshot wounds involving the lateral mass and/or bodies of the atlantoaxial complex were identified. All but 2 patients sustained a vertebral artery injury. Each patient was evaluated using cervical radiographs, CT scans, and vascular imaging, 8 in the form of digital subtraction angiography and 2 with high-resolution CT angiography. Uncomplicated patients were treated conservatively using cervical collar immobilization, local wound care, and antibiotics. One patient was treated using a halo for instability and 1 underwent posterior fusion following a posterolateral decompression for delayed myelopathy. One patient underwent transoral resection of a bullet fragment. One patient underwent embolization for a symptomatic arteriovenous fistula and a second patient underwent a neck exploration and a jugular vein ligation. None of the patients received anticoagulation therapy. The mean follow-up duration was 13 months. All but 2 patients regained their previous functional status and all ultimately attained a mechanically stable spine. Conclusions These 10 patients represent a rare form of cervical spine penetrating injury. Unilateral gunshot wounds to the atlantoaxial complex are usually stable and the need for acute surgical intervention is rare. Unilateral vertebral artery injury is well tolerated and any information provided by angiography does not alter the acute management of the patient. Vascular complications from gunshot wounds can be managed effectively by endovascular techniques.
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Wade, Katherine Jane. "The sword and the knife: a comparison of ancient Egyptian treatment of sword injuries and present day knife trauma." Res Medica 24, no. 1 (December 31, 2017): 47–56. http://dx.doi.org/10.2218/resmedica.v24i1.1494.
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The Edwin Smith papyrus is the oldest known surgical treatise, thought to have been written in 1700 B.C. It was first discovered in Luxor in 1862 and was first translated from hieroglyph script by Egyptologist, James Henry Breasted in 1930. The papyrus details forty eight traumatic injuries which are topographically organised and considered formulaically through examination, diagnosis, prognosis and treatment.The Khopesh was an ancient Egyptian sickle shaped sword which was thought to have been used to inflict a slash-type sharp force injury during battle. Treatment of these slash-type wounds as described in the Edwin Smith papyrus are compared with the current treatment of equivalent slash-type injuries, commonly knife wounds in the twenty first century.Comparison of a variety of components involved in the treatment of historical and modern slash-type sharp force wounds has illustrated that despite advances in medical practice, some of the basic principles of our current treatment regimes are derived from practices established thousands of years ago by the ancient Egyptians.
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Langford, Jane H., Phillip Artemi, and Shalom I. Benrimoj. "Topical Antimicrobial Prophylaxis in Minor Wounds." Annals of Pharmacotherapy 31, no. 5 (May 1997): 559–63. http://dx.doi.org/10.1177/106002809703100506.
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OBJECTIVE: To evaluate the ability of a novel topical antimicrobial gel containing cetrimide, bacitracin, and polymyxin B sulfate to prevent infections of minor wounds. DESIGN: A clinical trial compared the test preparation with placebo and a povidone iodine antiseptic cream. SETTING: Five primary schools in Sydney, Australia, participated in the study over a 6-week spring/summer school term. SUBJECTS: Children aged 5–12 years with parental consent were eligible for study participation. Accidental injuries occurring at school were treated in a standardized manner by nurses at each site. OUTCOME MEASURES: Wounds were evaluated by the medical practitioner after 3 days of topical treatment. The clinical outcome was classified as resolution or suspected infection. If a clinical infection was suspected, the injury was swabbed for microbiologic evaluation. Growth of a dominant microorganism was classified as a microbiologic infection. RESULTS: Of the 177 injuries treated, there were nine clinical infections. A comparison of these showed a significant difference among treatment groups (p < 0.05). This difference was associated with the test preparation and placebo; the test preparation reduced the incidence of clinical infection from 12.5% to 1.6% (p < 0.05; 95% CI, 0.011 to 0.207). A comparison of microbiologic infections showed no significant differences among treatment groups (p > 0.05). CONCLUSIONS: The novel gel preparation containing cetrimide, bacitracin, and polymyxin B sulfate showed therapeutic action and reduced the incidence of clinical infections in minor accidental wounds. It may be a suitable product for first aid prophylaxis.
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Weiss, Janet M. "Treatment of Leg Edema and Wounds in a Patient With Severe Musculoskeletal Injuries." Physical Therapy 78, no. 10 (October 1, 1998): 1104–13. http://dx.doi.org/10.1093/ptj/78.10.1104.
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Johnson, F. E., Y. Wang, T. Ling, S. Chuang, S. S. Huang, and J. S. Huang. "Synthetic TGF-ß antagonist promotes healing of injured epithelial surfaces." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 18586. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.18586.
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18586 Background: Cancer treatment often results in injury to epithelial surfaces. These injuries are often symptomatic and can delay or prevent further treatment. Since transforming growth factor-1 (TGF-ß) mediates inflammation, fibrosis, and epithelial mitogenesis, agents modulating TGF-ß may be useful in treating such wounds. We synthesized a dodecapeptide containing the active site of human TGF-ß. It is a TGF-ß antagonist in vitro. We investigated whether application to cutaneous wounds might promote epithelialization and decrease scarring by directly blocking local TGF-ß activity. Methods: We applied synthetic TGF-ß antagonist (1.5 mM in gel carrier, topically), with gel-only and no-treatment controls, to 6 standardized thermal burn wounds in each of 4 pigs. Wounds were measured and photographed for 41 d., then excised. Wound dimensions and percent epithelialization were calculated from photographs. Scar volume was estimated as surface area (photographs) x depth (microscopy). Statistical analysis employed student’s t-test. Additional experiments utilized skin excision wounds in rabbits and pigs. Recombinant TGF-ß and platelet-derived growth factor (PDGF) were applied to identical wounds in other pigs and rabbits in parallel experiments as additional controls. Results: In TGF-ß antagonist-treated pig burn wounds, epithelialization was complete on d. 26 ± 2 (mean ± SD); control wounds were 70 ± 10% re-epithelialized by d. 26 (p < 0.001). Contraction rate, collagen and fibronectin content, and scar volume were all significantly less in treated wounds. TGF- ß and PDGF each retarded wound epithelialization. Conclusions: Treatment of standard skin wounds with a synthetic TGF-ß antagonist promotes epithelialization in a whole-animal model. This agent may be useful in human epithelial injuries due to chemotherapy or radiation. No significant financial relationships to disclose.
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Smaropoulos, Eleftherios, and Niels AJ Cremers. "Medical grade honey for the treatment of paediatric abdominal wounds: a case series." Journal of Wound Care 29, no. 2 (February 2, 2020): 94–99. http://dx.doi.org/10.12968/jowc.2020.29.2.94.
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Objective: Children are at high risk of injuries and wounds. The application of medical grade honey is a promising approach to improving the healing of wounds of various origin and severity. However, the use of medical grade honey in young paediatric patients remains limited. The aim of this study is to show the safety, efficacy and usefulness of medical grade honey in abdominal wounds, of different causes, in paediatric patients. Method: This was a prospective, observational case series evaluating five young infants with abdominal wounds at the General Hospital in Thessaloniki. All wounds were treated in the same manner with daily medical grade honey applied to the wound area and closely monitored. Results: All treated wounds rapidly presented granulation tissue formation and underwent re-epithelialisation. Peripheral oedema and inflammation decreased upon initial application. Necrotic tissue was effectively debrided when present. Slough was removed and no signs of infection were detected, irrespective of initial wound presentations. Scar formation was minimal and the full range of motion was preserved in all cases. Conclusion: Based on this case study, medical grade honey is safe and effective in treating different abdominal wounds, including infected or dehisced wounds as well as burns. The easy application and broad applicability make medical grade honey recommendable as a first-line treatment in paediatric patients.
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Samokhvalov, I. M., K. P. Golovko, V. V. Boyarintsev, V. I. Badalov, T. Yu Suprun, A. M. Nosov, A. B. Vertiy, V. V. Denisenko, V. A. Chupriaev, and M. S. Grishin. "Concept formulation for the early-stage pathogenetic treatment of the severe injuries and traumas." Bulletin of the Russian Military Medical Academy 22, no. 3 (December 15, 2020): 23–28. http://dx.doi.org/10.17816/brmma50526.
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Abstract. 451 lethal outcomes of 5581 casualties with gunshot wounds occurring at the medical treatment facilities have been analyzed. Total lethality rate was 8,1%. Lethal outcome time varied from 1 to 19 days (10,61,9). 50,3% of casualties died during the advanced trauma management (Role 2), 17,3% at the Role 3 hospitals, 32,4% at the Role 4 hospitals. The predominant injury localization causing death was abdominal wounds 34,8%, and head injuries 23,1%. The main cause of death of wounds casualties arriving at the medical treatment facilities was life-threatening injury consequences (34,8%) and developing complications (45,5%). Fatal injuries to the major organs and permanent blood loss were considered to be the cause of death in 19,7% of casualties. 37% of the total number of lethal outcomes died because of acute blood loss, in 77,2% of cases it was internal hemorrhage, in 22,8% external hemorrhage. In 1% of cases early death was caused by acute respiratory failure. In general, the development of more than one third of lethal outcomes could be prevented. Special medical products and equipment were developed by the Department of War Surgery Kirov Military Medical Academy, RF Ministry of Defense in cooperation with the leading research and educational establishments and production enterprises. They are: equipment for the prehospital hemorrhage control, asphyxia management, open and tension pneumothorax management, traumatic shock treatment and complication prevention, as well as activities for creating devices controlling internal hemorrhage. All these form the basis for elimination of life-threatening consequences of injuries at the prehospital stage. This allows us to discuss the development of the idea of a traumatic disease, being put forward by professor Ilia Deriabin, in terms of the concept of the early-stage pathogenetic treatment of the severe injuries and traumas.
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Dutta, Anupam, Taniya Sarkar Dutta, Anup Kumar Das, and Pranoy Dey. "Haemostatic action of a topical foam-based patch (VELSEAL-T) in haemophiliac patients with external bleeding." Journal of Haemophilia Practice 7, no. 1 (June 17, 2020): 78–84. http://dx.doi.org/10.17225/jhp00160.
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AbstractIntroductionHaemophilia is an X-linked congenital bleeding disorder due to deficiency of coagulation factor VIII (in haemophilia A) or factor IX (in haemophilia B) caused by mutations of the respective clotting factor genes. Treatment involves the administration of an appropriate dose of factor concentrate, as soon as possible, in the event of any bleeding episode. In low-resource settings, such as Northeast India, where factor concentrates are not widely available, people with haemophilia (PwH) may bleed profusely even from trivial external injuries, warranting transfusion of blood or blood products. We previously reported on the use of a low cost, foam-based haemostatic patch to treat an external bleed in a single patient. In this study, we investigated its use to treat a range of external injuries in PwH presenting at Assam Medical College and Hospital.MethodOver 24 months, eligible PwH with external injuries attending our haemophilia clinic were treated with a topical haemostatic patch (VELSEAL-T) at the target bleeding site. The time to cessation of bleeding was recorded and the wound sites evaluated after haemostasis to monitor efficacy and safety.ResultsOut of 72 individuals with bleeding disorders who volunteered to participate, 59 cases of external bleeding in 48 PwH were eligible for inclusion in the study. Nine (15.3%) had aberration wounds, 24 (40.7%) cut wounds, 21 (35.6%) tooth and/or gum bleeding and five (8.4%) bleeding from puncture wounds. The average time required for achievement of haemostasis was 9.9 (±4.7) minutes. Aberration wounds required the least amount of time for haemostasis at 7.3 (±4.4) minutes. Cut wounds required a mean time of 8.5 (±2.9) minutes; puncture wounds required 9.0 (±3.1) minutes; gum bleeding required the longest time to achieve haemostasis with a mean of 12.7 (±5.6) minutes.ConclusionThe use of this topical haemostatic patch has been shown to be beneficial in the treatment of external injuries in PwH, and provides a good treatment option in resource-constrained areas. A larger controlled study would be helpful to further investigate its efficacy and safety.
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Widhyari, Sus Derthi, Ietje Wientarsih, Aulia Andi Mustika, April Hari Wardhana, Dodi Darmakusuma, Lina Noviyanti Sutardi, and Muhammad Bintang. "Potensi Salep Ekstrak Daun Sirih Merah Terhadap Profil Eritrogram Sebagai Terapi pada Luka Miasis (THE EFFECT OF RED BETEL LEAF EXTRACT OINTMENT IN ERYTHROGRAM PROFILES AS THERAPY IN MYASIS WOUND)." Jurnal Veteriner 19, no. 1 (June 26, 2018): 30. http://dx.doi.org/10.19087/jveteriner.2018.19.1.30.
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The objectives of this research was to examine the efficacy of red betel extract ointment to eritrogram profiles in infected sheep myiasis. Fifteen female sheeps were divided into five treatments, which were sheep without wound, treated with asuntol 2%, without any treatment,with red betel leaf extract ointment 2% and 4 %. Three incision wounds were made on the sheep’s back, 50 larvae given to every wounds to four treatment, except the healthy sheep (K). Blood was taken on the 0, 3th and 7th to determine erythrocytes counts, hematocrit values (PCV) and hemoglobin levels (Hb). The result showed that oitment of red betel leaf extract do not change the erythrogram profiles. The administration of red betel leaf extract ointment 4% has better eritrogram profiles than 2% Oitment of red betel leaf extract can be used as myasis therapy.
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KULCHESKI, ÁLYNSON LAROCCA, XAVIER SOLER I. GRAELLS, ANDRÉ LUÍS SEBBEN, MARCEL LUIZ BENATO, and PEDRO GREIN DEL SANTORO. "MANAGEMENT OF SPINAL GUNSHOT WOUND INJURIES." Coluna/Columna 20, no. 3 (September 2021): 217–23. http://dx.doi.org/10.1590/s1808-185120212003242926.
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ABSTRACT Objectives Elaborate a care protocol for spinal gunshot wounds (GSWs), based on the experience of more than fifteen years of treating this type of injury. Methods A retrospective cross-sectional analysis of the electronic medical record data of a tertiary hospital related to the treatment of spinal GSWs between January 2002 and January 2018. Results The management proposed was applied to 700 patients. Epidemiological data collected describes the population served. Conclusions An easy-to-use treatment flowchart was developed that, according to factors related to the neurological condition, projectile location, lesion stability and additional criteria, allows the objective determination of the best treatment option for each case. Level of evidence II; Retrospective Study.
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Galili, Uri. "Acceleration of Wound Healing byα-gal Nanoparticles Interacting with the Natural Anti-Gal Antibody." Journal of Immunology Research 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/589648.
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Application ofα-gal nanoparticles to wounds and burns induces accelerated healing by harnessing the natural anti-Gal antibody which constitutes ~1% of human immunoglobulins.α-gal nanoparticles present multipleα-gal epitopes (Galα1-3Galβ1-4GlcNAc-R), the carbohydrate ligand of anti-Gal. Studiedα-gal nanoparticles were comprised of glycolipids withα-gal epitopes, phospholipids, and cholesterol. Binding of anti-Gal toα-gal nanoparticles in wounds activates the complement cascade, resulting in formation of chemotactic complement cleavage peptides that induce rapid recruitment of many macrophages. The Fc/Fcγreceptors interaction between anti-Gal coatingα-gal nanoparticles and the recruited macrophages activates macrophages to produce cytokines/growth factors that promote wound healing and recruit stem cells. Studies of wound healing byα-gal nanoparticles were feasible inα1,3galactosyltransferase knockout mice and pigs. In contrast to other nonprimate mammals, these mice and pigs lack theα-gal epitope, and thus they are not immunotolerant to it and produce anti-Gal. Treatment of skin wounds and burns withα-gal nanoparticles resulted in 40–60% decrease in healing time in comparison with control wounds treated with saline. This accelerated healing is associated with increased recruitment of macrophages and extensive angiogenesis in wounds, faster regrowth of epidermis, and regeneration of the dermis. The accelerated healing further decreases and may completely eliminate fibrosis and scar formation in wounds. Since healing of internal injuries is mediated by mechanisms similar to those in external wound healing, it is suggested thatα-gal nanoparticles treatment may also improve regeneration and restoration of biological function following internal injuries such as surgical incisions, myocardial ischemia following infarction, and nerve injuries.
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Abdurakhmonov, Farkhod Rakhmonovich, Jasur Alimdjanovich Rizayev, and Shukhrat Abdujajilovich Boymurodov. "Assessment Of The Consequences Of The Ozone For The Treatment Of The Soft Tissue Injuries Of The Maxillofacial Area." American Journal of Medical Sciences and Pharmaceutical Research 03, no. 06 (June 10, 2021): 75–81. http://dx.doi.org/10.37547/tajmspr/volume03issue06-12.
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As it is clear that wounds of the maxillofacial area are much more different from other parts of the body. Due to the importance of its function and cosmetic value combined soft tissue lesions occupy a special position in human bones and tissues. In this article certain valuable information is shown about ozone’s physical, chemical compositions and its positive effect on the recovery of the combined soft tissue wounds located in the facial region. To evaluate the effectiveness of ozone for the treatment of soft tissue wounds of maxillofacial injuries overall 60 patients investigated [1,2]. As a result of this, ozone tends to be much more effective than traditional ways of treatments
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Miller, Keith R., Matthew V. Benns, Matthew C. Bozeman, Glen A. Franklin, Briang Harbrecht, Nicholas A. Nash, Jason W. Smith, William S. Smock, and J. David Richardson. "Operative Management of Thoracic Gunshot Wounds: More Aggressive Treatment Has Been Required over Time." American Surgeon 85, no. 11 (November 2019): 1205–8. http://dx.doi.org/10.1177/000313481908501123.
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Our department has a database of thoracic gunshot wounds (GSWs), which has cataloged these injury patterns over the past five decades. Prevailing wisdom on the management of these injuries suggested operative treatment beyond tube thoracostomy is not commonly required. It was our clinical impression that the operative treatment required beyond chest tube placement has greatly increased over the past several decades, whereas the operative management of cardiac GSWs seemed to be increasingly infrequent events. To test these observations, we analyzed the treatment of GSWs to the chest and heart in four distinct time periods, categorized as “historical” (1973–1975 and 1988–1990) and “modern” (2005–2007 and 2015–2017). There was a significant increase in emergent thoracotomy, delayed thoracic operations, overall operative interventions, and pulmonary resections from the historical period to the modern era. There was a decline in cardiac injuries treated, whereas the number of injuries remained constant. Mortality was unchanged between the early and later periods. Operative treatment beyond tube thoracostomy was much more prevalent for noncardiac thoracic GSWs in the past two decades than in the prior decades, whereas the number of cardiac wounds treated decreased by half.
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Madigan, J., J. Rowe, J. Angelos, W. F. Herthel, D. Matz, M. Dinucci, and V. Fletcher. "(A323) Wildfire Associated Burn Injury of 1400 Sheep in Northern California: A Coordinated Mass Casualty Veterinary Response." Prehospital and Disaster Medicine 26, S1 (May 2011): s90—s91. http://dx.doi.org/10.1017/s1049023x11003074.
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IntroductionWildfires can injure animals both from burns and inhalation of smoke and particulates. In 2006 a rapidly moving grass wildfire burned 12 square miles in Yolo County. Approximately 1400 sheep on the range suffered variable degrees of burns. A coordinated effort of triage and individual treatment or humane euthanasia was performed by the UC Davis Veterinary Emergency Response Team.MethodsAnimals: Two sheep ranches with 1100 (ranch A) and 300 (ranch b) adult sheep of different breeds, ranging in age from 1-6 years of age. Initial owner evaluation: Both ranchers considered humane destruction of all sheep showing evidence of burned discoloration, estimated to be over 95% of 1400 sheep. Ranch B attempted shooting comprised sheep but stopped and requested aid from UC Davis as did ranch A. Veterinary initial evaluation and communications: Several burned sheep were visible from the roadway. Many sheep were standing with limited movement and some were recumbent. Triage was performed by bringing food and water sources to the sheep and those not eating and drinking were evaluated first. Gunshot euthanasia following AVMA guidelines based on veterinary determination of hopeless prognosis was used. Veterinary team members (N = 25) coordinated treatments, communications with public health, animal control, and press media, carcass disposal, volunteer management, and acquisition of office of emergency services resources.TreatmentTopical treatment of eyes and skin burns with silver sulfadiazine ointment, administration of systemic antibiotics (LA 200), pain relief (flunixine meglumine), wound debridement, and cesarean section of late term terminal sheep were performed.ResultsOver 500 sheep were euthanized by gunshot and the remainder (approximately 900) recovered lasting from 1-42 days. Progression of burn injury to skin, udder, face, and hoofs persisted for 42 days.ConclusionA coordinated veterinary response provided humane care and triage of this mass casualty animal emergency.
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Carter, Jeffrey E., James H. Holmes, Kevin N. Foster, David J. Smith, and Jeffrey W. Shupp. "537 Autologous Skin Cell Suspension for the Treatment of Small (≤10% TBSA) Mixed-Depth Burns." Journal of Burn Care & Research 42, Supplement_1 (April 1, 2021): S116—S117. http://dx.doi.org/10.1093/jbcr/irab032.187.
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Abstract Introduction Split-thickness skin grafts (STSGs) have been the standard of care for many decades. Despite their widespread use, STSGs frequently fail. Autologous skin cell suspension (ASCS) is an FDA approved point of care regenerative medicine technology that reduces donor skin requirements without compromising clinical outcomes. ASCS allows for early treatment and less donor skin harvested that may be useful for hard-to-treat anatomical locations, in compromised patients that have risks for impaired wound healing, or elderly patients with thinner skin. We examined ASCS treatment as an adjunct to meshed autografts in adults with small mixed-depth/full-thickness burns. Methods We obtained IRB-approval for a prospective, multi-center, uncontrolled observational study that allowed continued access to ASCS before FDA approval (ClinicalTrials.gov Identifiers: NCT03333941). Subjects with mixed-depth/full-thickness injuries that required skin grafting with a minimum treatment area of 320 cm2 and burns ranging from 5–50% TBSA were eligible for study enrollment. Our analyses included only patients >18 years of age and ≤10% TBSA mixed-depth/full-thickness injuries that had completed the trial. All subjects had ≥1 burn wounds treated with meshed autografts (2:1–4:1) in combination with ASCS. Healing outcomes were accessed following ASCS treatment by direct visualization of each individual wound and included healing, scar outcomes, and safety data. Results Analyses included 20 subjects older than 18 years of age with ≤10% TBSA mixed-depth/full-thickness injuries. Of these, compromised wound healing was seen in 50.0% of subjects. Burn wounds with ≥90% re-epithelialization increased over time, with 62%, 80%, and 100% of wounds achieving closure at Weeks 1, 2, and 8, respectively. Similar results were seen in subjects with comorbidities known to affect wound healing and in elderly subjects despite their risks for impaired healing. Total POSAS patient (37.8 and 35.4) and observer scores were comparable (23.3 and 18.4) at Weeks 12 and 24. Safety events were typical for this patient population, and no serious adverse events occurred for any of the wounds. Conclusions This analysis provides additional information supporting the use of ASCS for the treatment of small, mixed-depth/full-thickness acute thermal burn injuries in adults, notably those with risk factors for impaired wound healing.
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Piccart, Frederik, JakobTitiaan Dormaar, Ruxandra Coropciuc, Joseph Schoenaers, Michel Bila, and Constantinus Politis. "Dog Bite Injuries in the Head and Neck Region: A 20-Year Review." Craniomaxillofacial Trauma & Reconstruction 12, no. 3 (September 2019): 199–204. http://dx.doi.org/10.1055/s-0038-1660441.
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Dog bite-related wounds seem to have become a common problem, especially when they relate to the head and neck region. According to Overall and Love, up to 18 per 1,000 people sustain a dog bite every year, of whom 3 need medical attention. Approximately 1 to 2% of bite injuries require hospitalization of the victims. Most of the lacerations are found in the upper lip and the nose regions and they are classified according to severity and concomitant damage to other organs. Bite wounds are considered “dirty” wounds and are prone to infection. When dealing with bite wounds, there is always an indication for antibiotic treatment. Broad-spectrum antibiotics like amoxicillin-clavulanate and/or moxifloxacin cover most of the pathogenic flora and should be administered in every bite wound case at risk of infection. This article would like to present a medical record review: a retrospective analysis of all bite wounds sustained in the head and neck region, treated at the University Hospital of Leuven over the past 20 years. Furthermore, it provides an overview of the current literature and its standings on the treatment of dog bite injuries in the maxillofacial region. We assessed both surgical and medical treatment options, as well as primary management, which includes infection prevention strategies, closure management, and additional vaccination requirements. Secondary management or scar revision methods will be mentioned. After conducting a UZ Leuven database search using keywords such as “dog,” “dog bite,” “face,” “head,” “lip,” and others, 223 patients were included. Age at the time of injury, location of the injury, treatment method used, and whether secondary infection was present or not were documented. All patients have been divided in age groups. We concluded that 21.52% was 5 years old or younger. Almost half of our patients (49.33%) were 18 years old or younger. Of all patients, 79 were hospitalized (35.43%). Primary closure was the treatment of choice. In 141 patients, the wounds were closed primarily (63.23%), resulting in only 2.24% reported secondary infections. Only one fatality was reported in our center over the course of 20 years (0.45%), a 6-year-old girl who had been attacked by her father's Rottweilers. Most patients who sustained dog bite injuries in the head and neck region seem to be children, specifically toddlers. Due to their height, it is possible they are more prone to dog bite injuries in the head and neck region. It is essential to optimize management of these injuries due to the impact they have on patients. This article provides the epidemiological data and clinical outcome of the approach at our center.
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Kotiv, B. N., I. M. Samokhvalov, V. Ju Markevich, I. I. Dzidzava, O. V. Barinov, V. V. Suvorov, A. V. Goncharov, and K. V. Petukhov. "Thoracoabdominal stab wounds: modern surgical tactics." Grekov's Bulletin of Surgery 178, no. 1 (March 28, 2019): 34–38. http://dx.doi.org/10.24884/0042-4625-2019-178-1-34-38.
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Theobjectivewas to determine the optimal therapeutic and diagnostic algorithm for thoracoabdominal injury.Material and methods. The results of the examination and treatment of 389 injured patients with combined stab wounds of chest and abdomen were analyzed. The injuries were thoracoabdominal in 54 (13.9 %) cases.Results. We analyzed instrumental invasive and non-invasive diagnostic methods. The sequence of surgical interventions was determined.Conclusion. We revealed that the correct sequence and volume of surgical intervention ensured the success of treating the injured patients, while in cases of competing sources of bleeding, priority should be given in favor of performing thoracotomy.
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Danchyn, A. O., O. M. Goncharuk, S. A. Usatov, M. S. Altabury, and G. O. Danchyn. "Biophysical mechanisms of the formation of wound channels in non-penetrating gunshot craniocerebral wounds." Ukrainian Interventional Neuroradiology and Surgery 35, no. 1 (June 30, 2021): 33–42. http://dx.doi.org/10.26683/2786-4855-2021-1(35)-33-42.
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Objective ‒ to develop recommendations for optimization of primary surgical treatment of gunshot penetrating craniocerebral wounds on the basis of theoretical and applied study of one of the sections of wound ballistics ‒ biophysical mechanisms of wound canal formation, concomitant impenetrable wounds and intracranial injuries.Materials and methods. The medical histories of 155 wounded who received a non-pe-netrating craniocerebral injury during the hostilities in the East of Ukraine in 2014‒2020 were studied. All of the wounded were males between 18 and 60 years old (mean age ‒ 35.1 years). To study the biophysical features of the formation of different types of wound canals at a given non-lethal kinetic energy transferred to the head tissues, the type of the wounding projectile, the flight trajectory, the nature of gunshot injuries to the soft tissues of the cranial vault and skull fractures and intracranial injuries were determined according to the data of clinical stu-dies and computed tomography and compared with the results of theoretical studies using the laws of wound ballistics.Results. There were 11 (7.1 %) bullet (only tangential) wounds, and 144 (92.9 %) shrapnel. The formation of wound channels depends on the type of the wounding projectile and its kinetic energy. Non-penetrating firearms bullet and shrapnel tangential craniocerebral wounds are caused by the destructive effect of injuring shells on the tissues, which at the moment of collision with the head have both destructive kinetic energy (>80 J) and less than destructive kinetic energy. Blind craniocerebral injuries are caused only by the traumatic effects of fragments with a small (<80 J) kinetic energy.Conclusions. With gunshot non-penetrating single shrapnel blind wounds, the wounds do not have a zone of secondary necrosis, and the zone of primary necrosis is small or insignificant, which makes it possible not to carve soft tissues around the wound during primary surgical treatment, but only to remove necrotic tissues. With gunshot non-penetrating shrapnel tangential and blind craniocerebral wounds, when the soft tissue wounds of the cranial vault do not gap, small size (damage to the skin, subcutaneous tissue to aponeurosis), primary surgical treatment is not performed. Such wounds are treated with a toilet and aseptic dressings. Wound canals ending in gunshot fractures are subject to primary surgical treatment in the same way as gunshot fractures.
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Irfan-maqsood, Muhammad. "Classification of Wounds: Know before Research and Clinical Practice." Journal of Genes and Cells 4 (January 15, 2018): 1. http://dx.doi.org/10.15562/gnc.61.
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Cutaneous wounds are known as the damages and injuries on the skin. Knowing the type of wound is very important before any kind of treatment or therapy being applied. Each type of wound is different from other due to the different structure, biology and pathophysiology, therefore, a kind of treatment for one wound cannot be specified for others. Considering the importance of types of wounds, these wounds are classified into different categories because of their different pathobiology. This manuscript would be a great piece of knowledge for the tissue engineer to develop specific skin substitute for specific wound which might help for the development of appropriate treatment strategies.
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Lihonenko, О. V., О. V. Storozhenko, А. B. Zubakha, І. А. Shumeiko, and І. О. Chorna. "Complex treatment of experimental purulent wound of soft tissues." Klinicheskaia khirurgiia 87, no. 7-8 (September 30, 2020): 58–62. http://dx.doi.org/10.26779/2522-1396.2020.7-8.58.
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Objective. To study the impact of estrogens and liposomes on course of healing process in purulent wounds of soft tissues in experiment.
Маterials and methods. Еxperimental investigation was done on 21 sheep. In the laboratory animals purulent-inflammatory process was simulated. Тhe laboratory animals were distributed into two groups: a control - 6 sheep and investigated - 15. All the animals obtained conventional therapy. In laboratory animals of the investigated group estrogens and liposomes were added to complex of the conventional treatment measures. The healing process course was controlled, using cytological, biochemical, planimetric and mathematic-statistical methods of investigation.
Results. Application of combined estrogen-liposomal therapy in complex treatment of experimental purulent wound of soft tissues have enhanced the levels of оxyprolene, ribonucleic and deoxyribonucleic acids in the wound area, raised a value of estradiol/testosteronic index, accelerated the wound cleansing, the granulations creation and shortened the wound healing process by (2.12 ± 0.24) days.
Conclusion. Including of estrogens and liposomes into the treatment complex for experimental purulent wound of soft tissues enhances cellular biosynthetic activity, activity of reparative processes in the wound area, accelerates the wound cleansing and the granulation creation, shortens the wound healing process and may be applied for improvement of the purulent wounds treatment in elderly and senile patients.
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Tkachenko, Pavlo I., Serhii O. Bilokon, Olha B. Dolenko, Nataliia M. Korotych, Yuliia V. Popelo, and Nataliia P. Bilokon. "BITTEN WOUNDS OF THE MAXILLOFACIAL AREA IN CHILDREN." Wiadomości Lekarskie 73, no. 6 (2020): 1108–13. http://dx.doi.org/10.36740/wlek202006105.
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The aim of the work is to determine the frequency, structure, features of clinical manifestations and treatment of bitten wounds of the face and neck in children of Poltava region. Materials and methods: It has been analyzed 91 histories of disease of thematic patients undergone treatment at the Surgical Department of Pediatric town clinical hospital of Poltava. Results: In the structure of traumatic injuries of maxillofacial area in children 5.3% were patients with bitten wounds of the face and neck. Among the injured were children of the age 7-12 years old (30.2%). In 74.7% of cases, the bites were complicated by acute inflammatory processes. Urban residents accounted for 71.8% of the total number of cases, while rural residents accounted for 28.2%. Boys were injured by 53.6% and girls by 46.4%. Sharps (74.5%), punctures (19.3%) and lacerations (6.2%) differed in form. The comprehensive treatment of patients with bitten maxillofacial area wounds was carried out according to the protocol of care. Conclusions: The clinical picture and severity of bitten wounds of maxillofacial area in children have individual features, which are largely due to topographic and anatomical localization of injuries. The choice of the optimal variant of primary surgical treatment of wounds and the amount of surgery should be determined individually depending on the severity of the injury, the time of injury. Special attention should be paid to normalization of psycho-emotional state of patients and prevention of scar formation.