Relevant bibliographies by topics / Sheep laminectomy

Academic literature on the topic 'Sheep laminectomy'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Sheep laminectomy"

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Klopp, Lisa S., William C. Welch, Joseph W. Tai, Jeffery M. Toth, G. Bryan Cornwall, and A. Simon Turner. "Use of polylactide resorbable film as a barrier to postoperative peridural adhesion in an ovine dorsal laminectomy model." Neurosurgical Focus 16, no. 3 (March 2004): 1–9. http://dx.doi.org/10.3171/foc.2004.16.3.3.

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Object The purpose of this study was to evaluate the performance of a resorbable polylactide film in the sheep posterior spine in the presence of a combined laminectomy and durotomy defect. Methods A resorbable polylactide film was used to cover the combined defects in the eight sheep used in this study. Two surgical levels were performed in each animal, with randomly assigned control and treated sites. Each surgical level consisted of a full laminectomy followed by a needle-induced durotomy. The treated levels received a resorbable polylactide film cut to size and tucked in under the laminar defect. At 8 to 10 weeks postoperatively, results of myelography and visual dye infiltration showed complete healing of the durotomies for all sites. In addition, evaluation of gross dissection based on volume and tenacity scores as well as histological findings indicates decreased posterior dural adhesions for sites treated with resorbable polylactide film. Conclusions The results of this investigation support previous studies in which the use of a resorbable polylactide film was found to be effective in reducing posterior dural adhesions in the spine with no apparent safety issues related to impaired dural healing.
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Boorman, Sophie, Amy L. Johnson, Thomas P. Schaer, and Marie-Eve Fecteau. "Clinical Findings, Treatments and Outcomes in Farm Animals with Vertebral Fractures or Luxations: 22 Cases (2006–2017)." Veterinary and Comparative Orthopaedics and Traumatology 32, no. 06 (June 26, 2019): 492–98. http://dx.doi.org/10.1055/s-0039-1692637.

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Objective The aim of this study was to describe the signalment, clinical presentation, diagnostic findings, medical and surgical treatment and outcome of 22 farm animals diagnosed with a vertebral fracture or luxation. Study design Medical records of 22 farm animals (7 goats, 6 alpacas, 5 cattle, 3 sheep and 1 deer) were reviewed for signalment, history, presenting clinical signs and neurological examination findings, clinicopathological results, diagnostic imaging, final diagnosis, medical and surgical management, clinical progression and outcome. Results Animals' age ranged from 1 day to 15 years. Neurological examination findings included decreased motor function (20/22), recumbency (14/22), altered mentation (13/22), cranial nerve deficits (4/22) and lack of nociception (3/22). Lesions were localized to the atlanto-occipital region (2/22), C1 to C5 (7/22), C6 to T2 (4/22), T3 to L3 (3/22), and L4 to S1 (6/22). Diagnoses included vertebral fracture only (4/22), luxation only (5/22) or both vertebral fracture and luxation (13/22). In five cases, no therapy was attempted, while 12 cases were treated medically and five cases were treated surgically. Surgical interventions included manual reduction (n = 1); arthrodesis (n = 2); laminectomy (n = 1); and laminectomy with pin fixation, cerclage wire and polymethylmethacrylate bridging (n = 1). Five of the 22 cases survived to hospital discharge; two of these were treated surgically. Conclusion The cervical region was most commonly affected. Prognosis for these injuries in farm animals is guarded.
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Herrera, Silvia Rejane Fontoura, Ricardo José de Almeida Leme, Paulo Roberto Valente, Élia Garcia Caldini, Paulo Hilário Nascimento Saldiva, and Denise Araujo Lapa Pedreira. "Comparison between two surgical techniques for prenatal correction of meningomyelocele in sheep." Einstein (São Paulo) 10, no. 4 (December 2012): 455–61. http://dx.doi.org/10.1590/s1679-45082012000400011.

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OBJECTIVE: To compare the classical neurosurgical technique with a new simplified technique for prenatal repair of a myelomeningocelelike defect in sheep. METHODS: A myelomeningocele-like defect (laminectomy and dural excision) was created in the lumbar region on day 90 of gestation in 9 pregnant sheep. Correction technique was randomized. In Group 1 the defect was corrected using the classic neurosurgical technique of three-layer suture (dura mater, muscle and skin closure) performed by a neurosurgeon. In Group 2, a fetal medicine specialist used a biosynthetic cellulose patch to protect the spinal cord and only the skin was sutured above it. Near term (day 132 of gestation) fetuses were sacrificed for pathological analysis. RESULTS: There were two miscarriages and one maternal death. In total, six cases were available for pathological analysis, three in each group. In Group 1, there were adherence of the spinal cord to the scar (meningo-neural adhesion) and spinal cord architecture loss with posterior funiculus destruction and no visualization of grey matter. In Group 2, we observed in all cases formation of a neo-dura mater, separating the nervous tissue from adjacent muscles, and preserving the posterior funiculus and grey matter. CONCLUSION: The new simplified technique was better than the classic neurosurgical technique. It preserved the nervous tissue and prevented the adherence of the spinal cord to the scar. This suggests the current technique used for the correction of spina bifida in humans may need to be reassessed.
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Cunningham, Bryan W., Breanna Seiber, Jessica R. Riggleman, Margaret R. Van Horn, and Archana Bhat. "An investigational study of a dual‐layer, chorion‐free amnion patch as a protective barrier following lumbar laminectomy in a sheep model." Journal of Tissue Engineering and Regenerative Medicine 13, no. 9 (July 18, 2019): 1664–71. http://dx.doi.org/10.1002/term.2920.

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Cunningham, Bryan W., Breanna Seiber, Jessica Riggleman, Margaret R. Van Horn, and Archana Bhat. "109. An investigational study of a dual-layer, chorion-free amnion patch as a protective barrier following lumbar laminectomy in a sheep model." Spine Journal 19, no. 9 (September 2019): S52—S53. http://dx.doi.org/10.1016/j.spinee.2019.05.122.

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Stokes, Sarah C., Jordan E. Jackson, Christina M. Theodorou, Christopher D. Pivetti, Priyadarsini Kumar, Kaeli J. Yamashiro, Aijun Wang, and Diana L. Farmer. "A Novel Model of Fetal Spinal Cord Exposure Allowing for Long-Term Postnatal Survival." Fetal Diagnosis and Therapy 48, no. 6 (2021): 472–78. http://dx.doi.org/10.1159/000516542.

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<b><i>Background:</i></b> The inherent morbidity associated with fetal ovine models of myelomeningocele (MMC) has created challenges for long-term survival of lambs. We aimed to develop a fetal ovine surgical spinal exposure model which could be used to evaluate long-term safety after direct spinal cord application of novel therapeutics for augmentation of in utero MMC repair. <b><i>Methods:</i></b> At gestational age (GA) 100–106, fetal lambs underwent surgical intervention. Laminectomy of L5–L6 was performed, dura was removed, and an experimental product was directly applied to the spinal cord. Paraspinal muscles and skin were closed and the fetus was returned to the uterus. Lambs were delivered via cesarean section at GA 140–142. Lambs were survived for 3 months with regular evaluation of motor function by the sheep locomotor rating scale. Spinal angulation was evaluated by magnetic resonance imaging at 2 weeks and 3 months. <b><i>Results:</i></b> Five fetal surgical intervention lambs and 6 control lambs who did not undergo surgical intervention were included. All lambs survived to the study endpoint of 3 months. No lambs had motor function abnormalities or increased spinal angulation. <b><i>Conclusion:</i></b> This model allows for long-term survival after fetal spinal cord exposure with product application directly onto the spinal cord.
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Herculano, Marco Antonio. "Inhibition of peridural fibrosis after laminectomy using biological sheet in rat model." Arquivos de Neuro-Psiquiatria 62, no. 4 (December 2004): 1114–15. http://dx.doi.org/10.1590/s0004-282x2004000600037.

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Siregar, Rais, and Sabri Ibrahim. "Intradural Extramedullary Spinal En-Plaque Meningioma With Calcification: A Case Report And Literature Review." Asian Australasian Neuro and Health Science Journal (AANHS-J) 3, no. 3 (December 27, 2021): 28–35. http://dx.doi.org/10.32734/aanhsj.v3i3.7607.

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Abstract Introduction: Intradural extramedullary (IDEM) tumors are benign neoplasms arising in the spinal canal about two-thirds of primary spinal tumors and 15% of tumors affecting the Central Nervous System. Spinal en-plaque meningioma is a type that grows in a sheet-like or collar-like, and incidence in the literature only ranging from 0.1% to 3.1%. Pain is the most clinical symptom, weakness and sensory changes also occur frequently. Magnetic resonance imaging (MRI) is the standard modality for the radiologic diagnosis of meningioma. Case Report: A patient, 35 years old man with a diagnosis of intradural extramedullary spinal meningioma (IDEM) en-plaque with calcification, confirmed by the symptoms, workups such as spinal MRI, and intra-operative findings. The patient was successfully treated surgically with laminectomy and total tumor resection with a posterior approach. Discussion: Spinal en-plaque meningioma is a type that grows in a sheet-like or collar-like manner around the spinal cord can involve dura extensively with significant neurological deficits. Patient was with lower limb weakness, and had a history of back pain radiating to the right limb for the last 1 year. Spinal meningiomas are primarily found in the Intradural Extramedullary, and the tumor diagnosis is typically fairly straight forward based on radiologic findings. Meningiomas are most commonly found in the thoracic region of the spine. In this case from MRI Imaging was revealed a mass in thoracic region of the spine pressing the spinal cord anteriorly. The management of spinal en-plaque meningioma is tumor resection surgery. A retrospective study suggested a significant improvement in neurological deficit post-tumor resection on patients with spinal IDEM tumor. Conclusion: Spinal meningioma is a reasonably frequently found case of a spinal tumor but spinal en-plaque meningiomas are rarely found. MRI scan is the radiological gold standar diagnose spinal en-plaque meningiomas. Patient was successfully treated by total tumor resection using the laminectomy method and tumor resection with a posterior approach without any postoperative complications observed.
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Altinoz, Meric A., Carlo Santaguida, Marie-Christine Guiot, and Rolando F. Del Maestro. "Spinal hemangioblastoma containing metastatic renal cell carcinoma in von Hippel—Lindau disease." Journal of Neurosurgery: Spine 3, no. 6 (December 2005): 495–500. http://dx.doi.org/10.3171/spi.2005.3.6.0495.

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✓ The authors describe the case of a patient with von Hippel—Lindau (VHL) disease in which a spinal hemangioblastoma contained metastatic renal cell carcinoma (RCC). The literature on tumor-to-tumor metastasis associated with VHL disease of the central nervous system (CNS) is reviewed. Midthoracic back pain developed in this 43-year-old man with a left-sided radicular component 2 years after he underwent resection of a left RCC. Radiological findings demonstrated a T6–7 intradural intramedullary lesion. A T5–8 laminectomy and gross-total resection of the spinal cord mass were performed. Light and electron microscopic examination showed features of hemangioblastoma, which contained metastatic foci of RCC. Genetic analysis demonstrated the presence of a deleting mutation in the first exon (nt. 394–406) of the VHL locus, truncating 16 amino acids (N61–77) from the first beta sheet in the VHL protein. A review of the literature revealed that RCC-to-CNS hemangioblastoma is the second most common donor—recipient tumor association among the tumor-to-tumor metastases.
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şahin, ali. "Effect of single-segment unilateral laminectomy and facetectomy on sheep lumbar spine stability: an in vitro biomechanical study." Southern Clinics of Istanbul Eurasia, 2021. http://dx.doi.org/10.14744/scie.2021.60024.

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Dissertations / Theses on the topic "Sheep laminectomy"

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Vediappan, Rajan Sundaresan. "Modifying Post-Surgical Wound Healing." Thesis, 2021. http://hdl.handle.net/2440/130740.

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“Surgery is a profession defined by its authority to cure by means of bodily invasion. The brutality and risks of opening a living person's body have long been apparent, the benefits only slowly and haltingly worked out”, says Atul Rawande on reviewing 200 yrs. of Surgery as a specialty in NEJM. My research focuses on working out these benefits, specifically looking at reduction of scar tissue formation in ENT, Abdominal & Spine surgery. Scar tissue formation is an outcome of healing process that can be excessive due to inflammation or infection and thereby has the ability to curtail the benefits or warrant revision surgery. Multiple strategies have been tested and employed thus far and none have given favourable results without causing additional harm or economic burden in health care costs. I propose to use a hydrogel synthesized by combining Chitosan and Dextran aldehyde -Chitin is an exoskeleton extracted polymer and Dextran Aldehyde a sugar, with added noveldrugs Deferiprone and Gallium Protoporphyrin providing additional anti scaring and antibiotic properties which could potentially augment the healing properties of the gel. I have conducted 3 types of studies. There are 2 animal studies and a Phase 1 Human clinical trial. The animal studies are an abdominal surgery rat model and a spine surgery sheep model. These studies show the safety and efficacy of this chitogel-drug combination at various dosages and illustrate the healing benefits of gel-drug combination.
Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2021
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