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Journal articles on the topic 'Sharp skin effect'
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No, Hyun-Ju, Yoon-Soo Kim, Hyung-Gun Nam, Hyun-Jae Shin, Eun-Mi Ryu, Myung-Soon Na, Byeong-Kwon Ahn, Du-Bok Choi, and Wol-Suk Cha. "Combined Treatment Effect of High Frequency Therapy with Sharp-Toothed Eel Extract on Men's Skin." KSBB Journal 26, no. 3 (June 30, 2011): 260–65. http://dx.doi.org/10.7841/ksbbj.2011.26.3.260.
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Aoyagi, Seiji, Kento Okuda, Tomokazu Takahashi, and Masato Suzuki. "Effect of Microneedle Cross-Sectional Shape on Puncture Resistance – Investigation of Polygonal and Star-Shaped Cross Sections –." Journal of Robotics and Mechatronics 32, no. 2 (April 20, 2020): 371–81. http://dx.doi.org/10.20965/jrm.2020.p0371.
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The shape of the needle tip that is currently used in the medical field is a “lancet point,” which is a diagonally cut cylindrical pipe, further cut on both sides. The shape of the needle shank is typically cylindrical. In this paper, tip and shank shapes that differ from the standard shape are experimentally investigated for the purpose of reducing puncture resistance. Microneedles of various cross-sectional shapes, such as polygonal and star-like, were fabricated using stereo laser lithography. Before the needle penetrates the skin, sharp edges at the needle tip may be effective to generate a stress concentration on the skin, inducing a skin fracture. After the needle penetrates the skin, corners in the cross section of the needle shank may effectively reduce the frictional resistance because the contact area between the skin and needle is limited at the corners. A needle insertion experiment was conducted against an artificial skin made of polydimethylsiloxane. The puncture resistance decreased respectively for the circular needle, polygonal needle, and star-shaped needle. For the star-shaped needles, the maximum resistance decreased as the number of corners (N) decreased. For the polygonal needle, the maximum resistance increased as N increased from 3 to 5; however, there was no observable difference for N from 6 to 8. The experimental results show that a triangular star-shaped microneedle is the most effective in reducing the puncture resistance.
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Škorjanc, Aleš, and Gregor Belušič. "Investigation of blood flow and the effect of vasoactive substances in cutaneous blood vessels of Xenopus laevis." Advances in Physiology Education 39, no. 2 (June 2015): 91–95. http://dx.doi.org/10.1152/advan.00160.2014.
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In the present study, a preparation of frog skin was presented, which can be used to demonstrate the basic concepts of blood flow regulation in a very clear and attractive way to high school and university students. In a freshly euthanized Xenopus, a patch of abdominal skin was exposed from the internal side and viewed with a USB microscope while it remained connected to a functioning circulatory system. In this way, it was possible to obtain sharp images of arteries and veins and to visualize blood flow. This allows students to learn about the functional differences between arteries and veins and about the complexity of hemodynamics as well as the particularities of the amphibian pulmocutaneous circulation. Students can then quantitatively estimate the effect of norepinephrine and epinephrine on the diameter of blood vessels by simply superfusing the skin patch with a series of solutions of the two substances. They can also test the effect of α-adrenergic receptor blockers, used to treat high blood pressure, on the norepinephrine-induced muscle tonus of blood vessels.
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Yang, Xiaosen, Yang Cao, and Yunjia Zhai. "Non-Hermitian Weyl semimetals: Non-Hermitian skin effect and non-Bloch bulk–boundary correspondence." Chinese Physics B 31, no. 1 (January 1, 2022): 010308. http://dx.doi.org/10.1088/1674-1056/ac3738.
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Abstract We investigate novel features of three-dimensional non-Hermitian Weyl semimetals, paying special attention to the unconventional bulk–boundary correspondence. We use the non-Bloch Chern numbers as the tool to obtain the topological phase diagram, which is also confirmed by the energy spectra from our numerical results. It is shown that, in sharp contrast to Hermitian systems, the conventional (Bloch) bulk–boundary correspondence breaks down in non-Hermitian topological semimetals, which is caused by the non-Hermitian skin effect. We establish the non-Bloch bulk–boundary correspondence for non-Hermitian Weyl semimetals: the topological edge modes are determined by the non-Bloch Chern number of the bulk bands. Moreover, these topological edge modes can manifest as the unidirectional edge motion, and their signatures are consistent with the non-Bloch bulk–boundary correspondence. Our work establishes the non-Bloch bulk–boundary correspondence for non-Hermitian topological semimetals.
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Elango, Jeevithan, Jung Lee, Shujun Wang, Yves Henrotin, José de Val, Joe M. Regenstein, Sun Lim, Bin Bao, and Wenhui Wu. "Evaluation of Differentiated Bone Cells Proliferation by Blue Shark Skin Collagen via Biochemical for Bone Tissue Engineering." Marine Drugs 16, no. 10 (September 25, 2018): 350. http://dx.doi.org/10.3390/md16100350.
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Collagen from a marine resource is believed to have more potential activity in bone tissue engineering and their bioactivity depends on biochemical and structural properties. Considering the above concept, pepsin soluble collagen (PSC) and acid soluble collagen (ASC) from blue shark (Prionace glauca) skin were extracted and its biochemical and osteogenic properties were investigated. The hydroxyproline content was higher in PSC than ASC and the purified collagens contained three distinct bands α1, α2, and β dimer. The purity of collagen was confirmed by the RP-HPLC profile and the thermogravimetric data showed a two-step thermal degradation pattern. ASC had a sharp decline in viscosity at 20–30 °C. Scanning electron microscope (SEM) images revealed the fibrillar network structure of collagens. Proliferation rates of the differentiated mouse bone marrow-mesenchymal stem (dMBMS) and differentiated osteoblastic (dMC3T3E1) cells were increased in collagen treated groups rather than the controls and the effect was dose-dependent, which was further supported by higher osteogenic protein and mRNA expression in collagen treated bone cells. Among two collagens, PSC had significantly increased dMBMS cell proliferation and this was materialized through increasing RUNX2 and collagen-I expression in bone cells. Accordingly, the collagens from blue shark skin with excellent biochemical and osteogenic properties could be a suitable biomaterial for therapeutic application.
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Mishra, Maneesh, and Martin Skote. "Drag Reduction in Turbulent Boundary Layers with Half Wave Wall Oscillations." Mathematical Problems in Engineering 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/253249.
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Spatial square waves with positive cycle are used as steady forcing technique to study drag reduction effects on a turbulent boundary layer flow. Pseudospectral method is used for performing direct numerical simulations on very high resolution grids. A smooth step function is employed to prevent Gibbs phenomenon at the sharp discontinuities of a square wave. The idea behind keeping only the positive cycle of the spatial forcing is to reduce the power consumption to boost net power savings. For some spatial frequency of the oscillations with half waves, it is possible to prevent recovery of skin friction back to the reference case values. A set of wall oscillation parameters is numerically simulated to study its effect on the power budget.
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Guo, Qiang, Kai He, Hengyuan Xu, and Youyi Wen. "The research on precise forming technology of “λ” type composite skin." Composites and Advanced Materials 30 (January 1, 2021): 263498332199474. http://dx.doi.org/10.1177/2634983321994749.
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With the application of “ λ” type composite skin becoming more and more extensive and diversified, its precise forming technology is also widely concerned. This article mainly solves the quality problems of “ λ” type corner area, such as delamination dispersion and surface wrinkle, which exist in reality commonly in the manufacturing process. The prepreg is heated along the corner area of the tooling to solve the problem that prepreg is difficult to be compacted due to the large modulus of carbon fiber in “ λ” type corner area. Furthermore, two precompaction tests are creatively increased at 16 layers (middle layer) and 32 layers (last layer) for the thick structure, respectively, to ensure the compaction effect of the blank. In addition, combined with the characteristics of highly elastic rubber and carbon fiber-reinforced materials, a new type of soft mold structure with proper flexibility and good stiffness is proposed innovatively through the reasonable placement of carbon fiber-reinforced materials and the setting of exhaust holes according to the structure characteristics of “ λ” type root skin. Through further process verification, it is shown that the improved process has effectively solved the problems of wrinkles and internal delamination at the sharp corners of parts and realized zero-defect manufacturing of “ λ” type root skin for the first time.
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Gossec, L., S. Siebert, P. Bergmans, K. De Vlam, E. Gremese, B. Joven-Ibáñez, T. Korotaeva, et al. "SAT0398 PERSISTENCE OF USTEKINUMAB (UST) OR TNF INHIBITOR (TNFI) TREATMENT IN PSORIATIC ARTHRITIS (PsA): INSIGHTS FROM THE LARGE, PROSPECTIVE, MULTINATIONAL, REAL-WORLD PsABio COHORT." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1149–50. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2127.
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Background:Several biologic DMARDs (bDMARDs) exist for PsA, TNFi and UST being the earliest on European markets. When bDMARDs are insufficiently effective, later-line bDMARDs typically have shorter persistence. Treatment persistence reflects a mix of effectiveness and adverse events (AEs), and persistence data are limited in PsA.Objectives:Comparative analysis of 1-year persistence of UST and TNFi within the prospective PsABio cohort.Methods:PsABio is an observational, multinational study of PsA patients (pts) treated with 1st to 3rd line UST or TNFi at their rheumatologist’s discretion.1Treatment persistence (up to 15 months of follow-up) was defined as time between start of first bDMARD treatment in PsABio, and either stop or switch to another bDMARD, or withdrawal.Persistence of UST and TNFi is shown by Kaplan-Meier curves and compared using Cox regression analysis, with propensity score (PS) to adjust for baseline imbalanced demographic and disease-related covariates (age, sex, bDMARD line, BMI, Clinical Disease Activity index for PSoriatic Arthritis [cDAPSA], 12-item PsA Impact of Disease [PsAID-12], Fibromyalgia Rapid Screening Tool [FiRST] score, co-treatments with MTX, NSAIDs, glucocorticoids, cardiovascular/metabolic comorbidities, dactylitis, enthesitis and body surface area [BSA]). Factors including concomitant MTX use and skin involvement: <3%, 3–10% and >10%, were added to the Cox model to investigate their impact on the PS-adjusted treatment effect.Results:Of 438 and 455 pts who started UST and TNF, respectively, 121 (28%) and 134 (29%) stopped or switched treatment before Month 15, with differences (as expected) according to treatment line (Fig. 1a, b). Reasons for stop/switch were related to safety/AEs in 12% (UST) and 28% (TNFi), and effectiveness (joints, nails or skin) in 77% (UST) and 69% (TNFi) of pts.The observed mean time on drug was 397 days for UST and 385 days for TNFi pts (1st line 410/397 days, 2nd 390/382 days, 3rd 381/338 days). Fig. 1b shows similar persistence for all drugs and treatment lines, except for lower persistence in TNFi 3rd line vs 1st/2nd. In PS-adjusted Cox analysis, no statistically significant difference between UST and TNFi persistence was seen; hazard ratio (HR; 95% CI) for stop/switch bDMARD (UST vs TNFi) was 0.82 (0.60, 1.13). In the model, bDMARD monotherapy (without MTX) and extensive skin involvement (BSA >10%), showed significantly better persistence for UST (HR 0.61 [0.42, 0.90] and 0.41 [0.19, 0.89] respectively; unadjusted Kaplan-Meier graphs shown in Fig. 1c, d). MTX co-therapy and low BSA did not affect the PS-adjusted treatment effect. Other factors added to the PS-adjusted Cox model did not show significant effects.Conclusion:In this real-world PsA cohort undergoing bDMARD treatment, persistence was generally comparable for UST and TNFi, but some clinical situations led to better drug persistence with UST compared to TNFi – particularly monotherapy, more extensive skin involvement, and in 3rd-line treatment. Our data emphasise the importance of skin involvement for pts with PsA.References:[1]Gossec L, et al.Ann Rheum Dis. 2018;77(suppl 2):Abstract AB0928Acknowledgments:This study was funded by Janssen.Disclosure of Interests:Laure Gossec Grant/research support from: Lilly, Mylan, Pfizer, Sandoz, Consultant of: AbbVie, Amgen, Biogen, Celgene, Janssen, Lilly, Novartis, Pfizer, Sandoz, Sanofi-Aventis, UCB, Stefan Siebert Grant/research support from: BMS, Boehringer Ingelheim, Celgene, GlaxoSmithKline, Janssen, Novartis, Pfizer, UCB, Consultant of: AbbVie, Boehringer Ingelheim, Janssen, Novartis, Pfizer, UCB, Speakers bureau: AbbVie, Celgene, Janssen, Novartis, Paul Bergmans Shareholder of: Johnson & Johnson, Employee of: Janssen, Kurt de Vlam Consultant of: Celgene Corporation, Eli Lilly, Novartis, Pfizer, UCB – consultant, Speakers bureau: Celgene Corporation, Eli Lilly, Novartis, Pfizer, UCB – speakers bureau and honoraria, Elisa Gremese Consultant of: AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Sanofi, UCB, Roche, Pfizer, Speakers bureau: AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Sanofi, UCB, Roche, Pfizer, Beatriz Joven-Ibáñez Speakers bureau: Abbvie, Celgene, Janssen, Merck Sharp & Dohme, Novartis, Pfizer, Tatiana Korotaeva Grant/research support from: Pfizer, Consultant of: Abbvie, BIOCAD, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Novartis-Sandoz, Pfizer, UCB, Speakers bureau: Abbvie, BIOCAD, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Novartis-Sandoz, Pfizer, UCB, Wim Noel Employee of: Janssen Pharmaceuticals NV, Michael T Nurmohamed Grant/research support from: Abbvie, Bristol-Myers Squibb, Celltrion, GlaxoSmithKline, Jansen, Eli Lilly, Menarini, Merck Sharp & Dohme, Mundipharma, Pfizer, Roche, Sanofi, USB, Consultant of: Abbvie, Bristol-Myers Squibb, Celltrion, GlaxoSmithKline, Jansen, Eli Lilly, Menarini, Merck Sharp & Dohme, Mundipharma, Pfizer, Roche, Sanofi, USB, Speakers bureau: Abbvie, Bristol-Myers Squibb, Celltrion, GlaxoSmithKline, Jansen, Eli Lilly, Menarini, Merck Sharp & Dohme, Mundipharma, Pfizer, Roche, Sanofi, USB, Petros Sfikakis Grant/research support from: Grant/research support from Abvie, Novartis, MSD, Actelion, Amgen, Pfizer, Janssen Pharmaceutical, UCB, Elke Theander Employee of: Janssen-Cilag Sweden AB, Josef S. Smolen Grant/research support from: AbbVie, AstraZeneca, Celgene, Celltrion, Chugai, Eli Lilly, Gilead, ILTOO, Janssen, Novartis-Sandoz, Pfizer Inc, Samsung, Sanofi, Consultant of: AbbVie, AstraZeneca, Celgene, Celltrion, Chugai, Eli Lilly, Gilead, ILTOO, Janssen, Novartis-Sandoz, Pfizer Inc, Samsung, Sanofi
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Mitchell, Ulrike H., Paul Stoneman, Robert E. Larson, and Garritt L. Page. "The Construction of Sham Dry Needles and Their Validity." Evidence-Based Complementary and Alternative Medicine 2018 (June 14, 2018): 1–6. http://dx.doi.org/10.1155/2018/9567061.
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Appropriate control interventions are necessary to show the treatment effect of dry needling. Different control procedures, such as dry needling of the contralateral side, and sham treatments, such as random and superficial needle insertion, have been utilized in trials. However, those methods might elicit a physiological response and are subsequently not ideal for use as a control. This descriptive study illustrates the construction of low-cost sham dry needles and evaluates their validity. Forty-two healthy asymptomatic subjects received either sham or real dry needling intervention to their right gluteal muscles and reported if they felt that the needle pierced the skin. They also graded the severity and qualified (sharp or dull) the pain associated with the intervention. The results showed that most of the subjects in both groups believed the needle penetrated the skin. The quantity of pain associated with the treatment was similar in both groups, but the quality assigned was different. The authors conclude that sham dry needling can be accomplished and used as a valid control treatment in dry needling research using these low-cost sham needles.
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Simeonovski, Viktor, Hristina Breshkovska, Silvija Duma, Ivana Dohcheva-Karajovanov, Katerina Damevska, and Suzana Nikolovska. "Hydroxyurea Associated Cutaneous Lesions: A Case Report." Open Access Macedonian Journal of Medical Sciences 6, no. 8 (August 19, 2018): 1458–61. http://dx.doi.org/10.3889/oamjms.2018.320.
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BACKGROUND: Hydroxyurea (HU) is an antimetabolite agent that interferes with the S-phase of cellular replication and inhibits DNA synthesis, with little or no effect on RNA or protein synthesis. It is used in the treatment of many myeloproliferative disorders (MD) and is particularly a first line treatment drug for intermediate to high-risk essential thrombocythemia. Although safe and very well tolerated by the patients suffering from MD, there have been numerous reports of a broad palette of cutaneous side effects associated with prolonged intake of the medication. These may include classical symptoms such as xerosis, diffuse hyperpigmentation, brown-nail discolouration, stomatitis and scaling of the face, hands, and feet or more serious side effects such as actinic keratosis lesions, leg ulcers and multiple skin carcinomas.CASE REPORT: We report a case of a 52-year-old man, on long-term therapy with HU for essential thrombocytosis, with several concurrent skin lesions. Despite the perennial use of HU, the cutaneous changes were neglected. The local dermatological examination revealed oval perimalleolar ulcer on the right leg, with dimensions 6 x 4 cm, clearly demarcated from the surroundings with regular margins, periulcerous erythema, with very deep and highly fibrinous bed of the ulcer, positive for bacterial infection. The ulcer was treated with topical wound therapy with alginate and parenteral antibiotics. The extended dermatological screening also showed two nummular lesions in the right brachial region, presenting as erythematous papules with sharp margins from the surrounding skin, gritty desquamation and dotted hyperpigmentations inside the lesion. Further dermoscopy and biopsy investigations confirmed a diagnosis of basal cell carcinoma. Nasal actinic keratosis was also noted. The patient was advised for discontinuing or substituting the HU therapy.CONCLUSION: We present this case to draw attention to the various cutaneous side effects that occur with perennial HU use and suggest an obligatory reference to a dermatological consult.
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Myronchenko, S. I. "OXIDATIVE AND ANTIOXIDANT PROCESSES IN THE FOCUS OF THE SKIN EXPOSED TO LOCAL ULTRAVIOLET IRRADIATION." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 19, no. 3 (November 8, 2019): 142–45. http://dx.doi.org/10.31718/2077-1096.19.3.142.
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The purpose of this study was to investigate the effect of local ultraviolet radiation on the content of lipid peroxidation products, lipofuscin, and the functioning of antioxidant enzymes in the skin of guinea pigs. Materials and methods. The studies were performed on 24 albino guinea pigs exposed to a single local ultraviolet radiation. The control group was made up of intact animals. The content of primary (diene conjugates) and secondary (TAC-active products) lipid peroxidation products, the activity of antioxidant enzymes (superoxide dismutase and catalase), and the content of lipofuscin were assessed in the skin in 2 hours, 4 hours, and on the 3rd and 8th day following the UV irradiation. Results. Under the influence of local ultraviolet radiation, all guinea pigs develop erythema (its peak is observed in 4 hours, and on the 3rd day), which disappears on the 8th day. There is a sharp enhancement of lipid peroxidation processes due to the accumulation of lipid peroxidation primary and secondary products in the skin of guinea pigs in all periods of the experiment. In parallel with the increase in lipid peroxidation products, there is a decrease in the activity of antioxidant enzymes (catalase and superoxide dismutase) in the focus of radiation. The content of lipofuscin in the skin progressively increases throughout the study period. Conclusions. The early erythema period following the local ultraviolet irradiation in the skin of guinea pigs, is characterized by increased content of diene conjugates and TBA-active products (in 2, 4 hours, on the 3rd day); decreased catalase activity and increased lipofuscin concentration (on the 3rd day after irradiation). The early post-erythema period (8th day) following the local ultraviolet irradiation is characterized by the accumulation of diene conjugates, TBA-active products and lipofuscin against the background of a decrease in the activity of catalase and superoxide dismutase in the skin of guinea pigs.
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Nikityuk, I. E., K. A. Afonichev, M. S. Nikitin, V. A. Kubasov, and V. V. Petrash. "Prolongation of viability of isolated skin explants by exposing them to their own transformed physical fields: experimental study." Perm Medical Journal 37, no. 6 (January 28, 2021): 131–42. http://dx.doi.org/10.17816/pmj376131-142.
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Objective. To study the effect of materials with optical-electrical properties on the survival of full-layer skin explants when they are isolated from the body with completely stopped trophic activity.
Material and methods. In rabbits of both sexes at the age of 5-6 months, full-layer skin flaps were excised from the back area, which were dissected into fragments-explants measuring 1.01.0 cm. All samples were thermostated for 2 days at 37 C near transducers represented by aluminum foil sheets and silicon single crystals. In the first series of experiments, the explants were directly in contact with the transducers; in the second and third series, screens made of light-proof black paper and thin glass were installed between the explants and the transducers, respectively. In each series, the experiments were repeated 5 times with each transducer. After thermostating, the explant viability index was evaluated by histological method in points.
Results. In the first and second series of experiments, the highest survival rate of explants with a viability index from 3.6 to 3.8 points with a norm of 4.0 points) was revealed depending on the type of transducer. In series III, when screening silicon crystals with thin glass, the explant survival rate decreased slightly to 3.3 points. However, the screening of aluminum foil with glass led to a sharp decrease in the viability of explants to 0.2 points.
Conclusions. A long-term viability of skin explants can be explained only by the effect of their own physical fields on them produced by the biostructures of explants and transformed by interaction with nearby materials possessing optical and electrical properties.
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Chamurlieva, M., E. Loginova, E. Gubar, Y. Korsakova, S. Glukhova, and T. Korotaeva. "AB0753 THE CONTRIBUTION OF JOINT SYMPTOMS, ENTHESITIS, SKIN AND NAIL PSORIASIS (PSO) TO MINIMAL DISEASE ACTIVITY (MDA) ACHIEVEMENT IN PSORIATIC ARTHRITIS (PSA) PATIENTS (PTS). EFFECT OF TOFACITINIB TREATMENT. DATA FROM REAL CLINICAL PRACTICE." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1673. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4114.
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Background:PsA is an inflammatory arthritis associated with skin and nail PsO. The treatment target of PsA is MDA. In order to achieve MDA it is necessary to significantly improve musculoskeletal (MSK) symptoms, skin symptoms and patient-reported outcomes (PROs). In RCT it has been recently demonstrated that targeting both joint and skin symptoms is very important in achieving optimal improvement in health-related quality of life [1]. However, there is not enough data from clinical practice. Tofacitinib (TF) is an oral Janus kinase inhibitor approved for the treatment of PsA pts.Objectives:to study the influence of joint, enthesitis, skin and nail symptoms on MDA achievement in active PsA (pts) treated with TF for 6 months (mo).Methods:41pts (M/F=24(58.5%)/17(41.5%) with active PsA fulfilling the CASPAR criteria, were included after signing consent participation forms. Mean age 42.4±10.3 years (yrs), median (Me) PsA duration 72 [35;120] mo, PsO duration 192 [98;312] mo, PASI 14.5 [7;23.8], DAPSA 44.2 [37.8;55.3]. Pts were treated with TF 5 mg twice daily. At baseline (BL) and over a period of 6 mo of therapy PsA activity was evaluated by Tender Joint Count (TJC68), Swollen Joint Count (SJC66); PGA, physician global assessment by Visual Analog Scale (VAS), DAPSA. Enthesitis was evaluated by LEI (Leeds Enthesial Index) plus Plantar Facia (PF); PROs were measured by PtGA VAS, PtPain VAS, HAQ. PsO were measured by PASI/BSA (%). The presence/absent of Nail PsO was evaluated. The number of pts (NPts) who reached MDA (5/7: TJC≤1, SJC≤1, PASI≤1/BSA≤3, PtPainGA≤15, PtGA≤20, HAQ≤0,5, enthesitis count≤1) was calculated. M±SD, Me[Q25;Q75], %, Pearson-χ2, OR 95% (CI) were performed. All p<0.05 were considered to indicate statistical significance.Results:At BL mean TJC/SJC/PtPainGA/PtGA/PASI/HAQ were 19[12;24]/11[8;16]/65[50;75]/70[50;80]/14.5[7;23.8]/1[0.625;1.5] accordingly. Enthesitis/Nail PsO were found in 27 pts (65.9%)/in 33 out of 41 pts (80.5%) respectively. BSA>3% was found in 20 out of 41 pts (51.3%). After 6 mo of therapy all MDA parameters as well as DAPSA score decreased significantly (table 1). The NPts with Enthesitis decreased significantly and became 12 out of 41 pts (30.8%). After 6 mo of therapy the NPts with nail PsO didn’t decrease significantly compared with the BL; the dynamics was: from 33 out of 41 pts (80.5%) to 31 (79.5%) accordingly (p=0.991). MDA was found in 15 out of 41 pts (36.58%). After 6 mo of therapy no significant differences were seen between the groups of pts with/without MDA in the NPts with nail PSO: 11 out of 15 pts (73.33%) and 20 out of 24 (83.3%) accordingly (p=0.456). Enthesitis, PASI, nail PsO had a negative impact on achieving MDA, while joint symptoms and PROs were significantly associated with MDA attainment after 6 mo of TF therapy (Fig. 1).Conclusion:In real clinical practice TF treatment improves all MSK symptoms in active PsA pts. The presence of Enthesitis and Skin/Nail PsO severity at BL has a negative impact on MDA attainment in short-term outcomes. These findings should be taken into consideration when choosing treatment.References:[1]Kavanaugh A, Gottlieb A, Morita A, et al. Ann Rheum Dis 2019;0:1–5. doi:10.1136/annrheumdis-2018-215003Research granted by Pfizer.Table 1.Change in all evaluated parameters from BL to 6 mo.Parameters,BLM±SD6 moM±SDTJC6818.1 ±9.84.9±5.0*SJC6612.8±7.72.5±4.0*DAPSA44.2±17.111.8±9.4*PtPain, VAS, mm65 [50; 75]18 [5;30]*PtGA, VAS, mm70 [50; 80]20 [10; 30]*PASI14.5 [7;23.8]5.6 [0;10.4]*LEI+PF1 [0;2]0[0;0]*HAQ1 [0.625; 1.5]0.5 [0; 0.875]** p<0.0001 – differences from BL/6 mo;Fig. 1.Forest plot Joint, Enthesitis, PROs, Skin/Nail PsO contribution in MDA attainment at 6 mo of TF therapy.Disclosure of Interests:Maria Chamurlieva: None declared, Elena Loginova Speakers bureau: Janssen, ELENA GUBAR: None declared, Yulia Korsakova: None declared, Svetlana Glukhova: None declared, Tatiana Korotaeva Grant/research support from: Pfizer, Consultant of: Abbvie, BIOCAD, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Novartis-Sandoz, Pfizer, UCB, Speakers bureau: Abbvie, BIOCAD, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Novartis-Sandoz, Pfizer, UCB
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Pan, Na, Bohui Liu, Xuemei Bao, Haochi Zhang, Shouxin Sheng, Yanchen Liang, Haiting Pan, and Xiao Wang. "Oral Delivery of Novel Recombinant Lactobacillus Elicit High Protection against Staphylococcus aureus Pulmonary and Skin Infections." Vaccines 9, no. 9 (September 3, 2021): 984. http://dx.doi.org/10.3390/vaccines9090984.
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Staphylococcus aureus is a leading cause of nosocomial and community-associated infection worldwide; however, there is no licensed vaccine available. S. aureus initiates infection via the mucosa; therefore, a mucosal vaccine is likely to be a promising approach against S. aureus infection. Lactobacilli, a non-pathogenic bacterium, has gained increasing interest as a mucosal delivery vehicle. Hence, we attempted to develop an oral S. aureus vaccine based on lactobacilli to cushion the stress of drug resistance and vaccine needs. In this study, we designed, constructed, and evaluated recombinant Lactobacillus strains synthesizing S. aureus nontoxic mutated α-hemolysins (HlaH35L). The results from animal clinical trials showed that recombinant Lactobacillus can persist for at least 72 h and can stably express heterologous protein in vivo. Recombinant L. plantarum WXD234 (pNZ8148-Hla) could induce robust mucosal immunity in the GALT, as evidenced by a significant increase in IgA and IL-17 production and the strong proliferation of T-lymphocytes derived from Peyer’s patches. WXD234 (pNZ8148-Hla) conferred up to 83% protection against S. aureus pulmonary infection and significantly reduced the abscess size in a S. aureus skin infection model. Of particular interest is the sharp reduction of the protective effect offered by WXD234 (pNZ8148-Hla) vaccination in γδ T cell-deficient or IL-17-deficient mice. In conclusion, for the first time, genetically engineered Lactobacillus WXD234 (pNZ8148-Hla) as an oral vaccine induced superior mucosal immunity, which was associated with high protection against pulmonary and skin infections caused by S. aureus. Taken together, our findings suggest the great potential for a delivery system based on lactobacilli and provide experimental data for the development of mucosal vaccines for S. aureus.
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Nurmohamed, M. T., I. Van der Horst-Bruinsma, A. W. Van Kuijk, S. Siebert, P. Bergmans, K. De Vlam, E. Gremese, et al. "SAT0432 EFFECT OF SEX ON DISEASE CHARACTERISTICS AND DISEASE IMPACT IN PATIENTS WITH PSORIATIC ARTHRITIS (PsA): INSIGHTS FROM THE REAL-WORLD, OBSERVATIONAL MULTINATIONAL PsABio COHORT." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1171.1–1173. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2771.
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Background:Female sex has been associated with more severe disease and poorer treatment outcomes in PsA. These observations are often based on small populations or national cohorts/registries.Objectives:To investigate the effects of sex on disease characteristics and disease impact in PsA, using data of 929 consecutive patients (pts) from PsABio.Methods:PsABio is a real-world, non-interventional European study in PsA pts treated with UST or TNFi based on their rheumatologist’s choice. Observed male and female baseline (BL) data were described and compared using 95% CI.Results:Women in PsABio (n=512 [55%]) were numerically older than men (mean [SD]: 50.5 [12.7] / 48.7 [12.3] years, respectively). Women were more obese (BMI >30), % (95% CI): F: 35 (30, 39), M: 24 (20, 29), men more overweight (BMI >25–30): F: 31 (27, 36), M:51 (46, 57). Age at diagnosis, delay from first symptom to diagnosis, and disease duration were similar for both sexes.Women entered PsABio more often on 3rd line treatment, whereas men started on 1st-line biologic treatment more often (F/M 1st line 47%/55%; 2nd line 34%/33%; 3rd line 20%/12%). Numerically, concomitant MTX was given more often to women vs men (32% vs 27%). At BL, 60% of women and 64% of men were on NSAIDs; 7.9% and 2.5% on antidepressant drugs. Women had significantly more comorbidities, with numerically more cardiovascular disease and anxiety/depression, and 3 times more IBD.Women had significantly higher 68 tender joint counts (TJC): 13.0 vs 10.4, while 66 swollen joint counts were not significantly different: 5.8 vs 5.5. Axial or combined axial-peripheral disease was similarly frequent, in 29% of women and 26% of men (Figs. 1, 2).Clinical Disease Activity index for PSoriatic Arthritis (cDAPSA) was higher in women (31.8 vs 27.3); pt-reported levels of pain, global disease activity (VAS scales) and higher TJC contributed to this. While enthesitis prevalence (based on Leeds Enthesitis Index) was comparable, men had significantly more frequent dactylitis, nail disease and worse skin psoriasis. At BL, 3.4% of women vs 7.1% of men, were in MDA.Regarding physical functioning (HAQ-DI), impact of disease (PSAID-12) and quality of life (EQ5D-3L health state), women with PsA starting a biologic (b)DMARD, expressed significantly greater negative impact and more limitations due to their disease (Fig. 2).Conclusion:In routine care, women with PsA starting a bDMARD presented with worse outcomes over a range of assessments compared with men (higher pt-reported pain and disease activity, TJC, and worse physical functioning and QoL), while men had worse dactylitis and psoriasis. Follow-up analysis will report whether the effects of biologic therapy are different in both sexes. The increased prevalence of associated features related to pain and impact on functioning and QoL may indicate the need for a more comprehensive treatment approach for women to avoid unnecessary and premature bDMARD stop or switch.Acknowledgments:This study was funded by Janssen.Disclosure of Interests:Michael T Nurmohamed Grant/research support from: Abbvie, Bristol-Myers Squibb, Celltrion, GlaxoSmithKline, Jansen, Eli Lilly, Menarini, Merck Sharp & Dohme, Mundipharma, Pfizer, Roche, Sanofi, USB, Consultant of: Abbvie, Bristol-Myers Squibb, Celltrion, GlaxoSmithKline, Jansen, Eli Lilly, Menarini, Merck Sharp & Dohme, Mundipharma, Pfizer, Roche, Sanofi, USB, Speakers bureau: Abbvie, Bristol-Myers Squibb, Celltrion, GlaxoSmithKline, Jansen, Eli Lilly, Menarini, Merck Sharp & Dohme, Mundipharma, Pfizer, Roche, Sanofi, USB, Irene van der Horst-Bruinsma Grant/research support from: AbbVie, Novartis, Eli Lilly, Bristol-Myers Squibb, MSD, Pfizer, UCB Pharma, Consultant of: AbbVie, Novartis, Eli Lilly, Bristol-Myers Squibb, MSD, Pfizer, UCB Pharma, Arno WR van Kuijk Grant/research support from: Janssen, Stefan Siebert Grant/research support from: BMS, Boehringer Ingelheim, Celgene, GlaxoSmithKline, Janssen, Novartis, Pfizer, UCB, Consultant of: AbbVie, Boehringer Ingelheim, Janssen, Novartis, Pfizer, UCB, Speakers bureau: AbbVie, Celgene, Janssen, Novartis, Paul Bergmans Shareholder of: Johnson & Johnson, Employee of: Janssen, Kurt de Vlam Consultant of: Celgene Corporation, Eli Lilly, Novartis, Pfizer, UCB – consultant, Speakers bureau: Celgene Corporation, Eli Lilly, Novartis, Pfizer, UCB – speakers bureau and honoraria, Elisa Gremese Consultant of: AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Sanofi, UCB, Roche, Pfizer, Speakers bureau: AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Sanofi, UCB, Roche, Pfizer, Beatriz Joven-Ibáñez Speakers bureau: Abbvie, Celgene, Janssen, Merck Sharp & Dohme, Novartis, Pfizer, Tatiana Korotaeva Grant/research support from: Pfizer, Consultant of: Abbvie, BIOCAD, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Novartis-Sandoz, Pfizer, UCB, Speakers bureau: Abbvie, BIOCAD, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Merck Sharp & Dohme, Novartis, Novartis-Sandoz, Pfizer, UCB, Wim Noel Employee of: Janssen Pharmaceuticals NV, Petros Sfikakis Grant/research support from: Grant/research support from Abvie, Novartis, MSD, Actelion, Amgen, Pfizer, Janssen Pharmaceutical, UCB, Elke Theander Employee of: Janssen-Cilag Sweden AB, Josef S. Smolen Grant/research support from: AbbVie, AstraZeneca, Celgene, Celltrion, Chugai, Eli Lilly, Gilead, ILTOO, Janssen, Novartis-Sandoz, Pfizer Inc, Samsung, Sanofi, Consultant of: AbbVie, AstraZeneca, Celgene, Celltrion, Chugai, Eli Lilly, Gilead, ILTOO, Janssen, Novartis-Sandoz, Pfizer Inc, Samsung, Sanofi, Laure Gossec Grant/research support from: Lilly, Mylan, Pfizer, Sandoz, Consultant of: AbbVie, Amgen, Biogen, Celgene, Janssen, Lilly, Novartis, Pfizer, Sandoz, Sanofi-Aventis, UCB
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Kim, Jun-Sub, and Ssang-Taek Steve Lim. "LED Light-Induced ROS Differentially Regulates Focal Adhesion Kinase Activity in HaCaT Cell Viability." Current Issues in Molecular Biology 44, no. 3 (March 4, 2022): 1235–46. http://dx.doi.org/10.3390/cimb44030082.
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In this study, changes in cell signaling mechanisms in skin cells induced by various wavelengths and intensities of light-emitting diodes (LED) were investigated, focusing on the activity of focal adhesion kinase (FAK) in particular. We examined the effect of LED irradiation on cell survival, the generation of intracellular reactive oxygen species (ROS), and the activity of various cell-signaling proteins. Red LED light increased cell viability at all intensities, whereas strong green and blue LED light reduced cell viability, and this effect was reversed by NAC or DPI treatment. Red LED light caused an increase in ROS formation according to the increase in the intensity of the LED light, and green and blue LED lights led to sharp increases in ROS formation. In the initial reaction to LEDs, red LED light only increased the phosphorylation of FAK and extracellular-signal regulated protein kinase (ERK), whereas green and blue LED lights increased the phosphorylation of inhibitory-κB Kinase α (IKKα), c-jun N-terminal kinase (JNK), and p38. The phosphorylation of these intracellular proteins was reduced via FAK inhibitor, NAC, and DPI treatments. Even after 24 h of LED irradiation, the activity of FAK and ERK appeared in cells treated with red LED light but did not appear in cells treated with green and blue LED lights. Furthermore, the activity of caspase-3 was confirmed along with cell detachment. Therefore, our results suggest that red LED light induced mitogenic effects via low levels of ROS–FAK–ERK, while green and blue LED lights induced cytotoxic effects via cellular stress and apoptosis signaling resulting from high levels of ROS.
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Michalaki, Marina, Apostolos G. Vagenakis, Maria Makri, Fotios Kalfarentzos, and Venetsana Kyriazopoulou. "Dissociation of the Early Decline in Serum T3 Concentration and Serum IL-6 Rise and TNFα in Nonthyroidal Illness Syndrome Induced by Abdominal Surgery." Journal of Clinical Endocrinology & Metabolism 86, no. 9 (September 1, 2001): 4198–205. http://dx.doi.org/10.1210/jcem.86.9.7795.
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The etiology of the prompt decline in serum T3 in patients with nonthyroidal illness syndrome has not been adequately explained. It has been attributed to various parameters, including test artifacts, inhibitors of T4 and T3 binding to proteins, decreased 5′-deiodinase activity, and circulating cytokines. Currently, much attention is centered on the role of IL-6 and TNFα in developing the nonthyroidal illness syndrome through an effect on the hypothalamus, pituitary, and possibly 5′-deiodinase activity. We therefore studied the relation of the endogenous serum IL-6 and TNFα rise early in the course of nonthyroidal illness syndrome to the early decline in serum T3 in 19 apparently healthy individuals, aged 43 ± 16 yr, who underwent elective abdominal surgery for cholelithiasis or gastroplasty. Serum T3, free T3, T4, free T4, rT3, TSH, IL-6, and TNFα were measured before and at various time intervals up to 42 h after skin incision. We observed a prompt decline in serum T3 30 min before skin incision, which continued to decline throughout the observational period. The magnitude of the decline reached 20% from the baseline value at 2 h. The early decline of T3 was attenuated and lasted from the 2–8 h, probably due to the sharp increase in serum TSH that started immediately after the entrance to the operating room and lasted for 2 h. In contrast, serum T4 and free T4 concentrations were increased soon after skin incision and remained elevated during the first postoperative day. Serum rT3 increased approximately 6 h after the initiation of surgery and remained elevated thereafter. Serum IL-6 remained essentially undetectable for 2 h after skin incision, whereas serum T3 was low. Two hours after skin incision, serum IL-6 increased sharply and remained elevated throughout the observational period. Serum TNFα remained essentially undetectable throughout the postoperative period. Serum cortisol increased rapidly upon entrance to the operating room and remained elevated throughout the postoperative period. We conclude that the decline in serum T3 early in the course of nonthyroidal illness syndrome is not due to increased serum IL-6 or TNFα levels. The brisk TSH secretion soon after the onset of the syndrome attenuates the decline in serum T3 due to T3 secretion from the thyroid. The early and brisk cortisol response to surgery may at least in part explain the early decrease in serum T3 in nonthyroidal illness syndrome.
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Ross, P. M. "Cellular and adenovirus dl312 DNA metabolism in cycling or mitotic human cultures exposed to supralethal gamma radiation." Journal of Cell Biology 109, no. 5 (November 1, 1989): 1993–2002. http://dx.doi.org/10.1083/jcb.109.5.1993.
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Cellular repair of DNA damage due to lethal gamma irradiation was studied to reveal differences between strains and cell cycle stages that are otherwise difficult to detect. Cycling and metaphase-blocked cultures of normal fibroblasts and carcinoma cells were compared for repair of gamma sites (gamma radiation-induced nicks, breaks, and alkalilabile sites in DNA) at supralethal exposures ranging from 7 to 150 krad 137Cs radiation and at postirradiation incubations of 20-180 min. Fibroblasts from normal human skin or lung repaired gamma sites efficiently when cycling but did not repair them when blocked at mitosis. Bladder (253J) or lung (A549) carcinoma cells, unlike normal fibroblasts, repaired gamma sites efficiently even when blocked at mitosis. HeLa cells degraded their DNA soon after exposure at all doses tested, regardless of mitotic arrest. Whether the above differences in DNA repair between cell cycle stages and between strains result from differences in chromatin structure (cis effects) or from differences in the nuclear enzymatic environment (trans effects) could be resolved by placing an inert, extrachromosomal DNA molecule in the cell nucleus. Specifically, cis effects should be confined to the host chromosomes and would not be detected in the inert probe whereas trans effects should be detected in host chromosomes and inert probe DNA alike. Indeed, we found a suitable DNA molecule in the adenovirus deletion mutant dl312, which does not proliferate in the absence of E1A complementation. Gamma sites in 32P-labeled adenovirus dl312 DNA were repaired efficiently in all hosts, regardless of mitotic arrest. Failure of mitosis-arrested fibroblasts to repair gamma sites was therefore due to a cis effect of chromatin organization rather than to a trans effect such as repair enzyme insufficiency. In sharp contrast, chromosomes of mitotic carcinoma cells remained accessible to repair enzymes and nucleases alike. By means of these new tools, we should get a better understanding of higher-order chromatin management in normal and cancer cells.
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Metlyaeva, Nelya, M. Lartsev, A. Bushmanov, I. Galstyan, L. Ryabinina, M. Sukhova, E. Skorobogatykh, A. Kirilchev, O. Shcherbatykh, and F. Torubarov. "Psychophysiological Aspects in the Clinical Picture of Disease in Patients Who Received Local Radiation Injury." Medical Radiology and radiation safety 66, no. 3 (July 20, 2021): 13–18. http://dx.doi.org/10.12737/1024-6177-2021-66-3-13-18.
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Purpose: To evaluate in dynamics the psychophysiological adaptation of a patient who received local radiation damage to the tissues of the left half of the chest IV (extremely severe) severity (23 years of observation).
Material and methods: Patient KTS, 66 years old, as the main diagnosis are the effects of local radiation damage to the skin and underlying tissues of the left half of the chest from external radiation (about 3 % of body surface area) IV extremely severe. Before receiving a radiation injury, she was able-bodied and socially adapted, worked as a nurse. In 1996, she was diagnosed with stage I left breast cancer T1N0M0 stage I, in connection with which she underwent a sectoral resection of the mammary gland. Then the patient underwent a course of radiation therapy. By retrospective assessment, the total dose of therapeutic effect before the incident was 10 Gy. At the time of the next session of radiation therapy in connection with the breakdown of the apparatus, a sharp uncontrolled increase in the dose of ionizing radiation (more than 100 Gy) occurred, causing serious injury. The patient was admitted to the Institute of Biophysics Clinic on the 5th day. Psychophysiological research was carried out with the use of automated software and methodic complex «Expert», designed to study the personal characteristics of a person, cognitive and intellectual personality characteristics in 2001 – 2017 years.
Results: The effects of local radiation damage to the skin and underlying tissues of the left half of the chest from external irradiation of IV (extremely severe) degree in the form of cicatricial-atrophic changes of the soft tissues, with no bone skeleton remain. Disorders of mental adaptation are expressed in the form of senesto-hypochondria disorders, autism of perception, demonstrativeness, apathetic depression and introversion. The most profound contribution to the reduction of the adaptation of the victim is brought about by the features of deep internal disharmony caused by contradictory combinations of demonstrativeness, schizoid traits, anxious depression and affective rigidity.
Conclusion: The data obtained indicate that impaired mental adaptation is an integral part of the clinical picture of local radiation injuries, and reveal the urgent need not only of specific treatment of radiation injury, but also of psychotropic pharmacotherapy and psychotherapy.
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Ruppel, A., R. Breternitz, and F. Lutz. "Schistosoma mansoni:stage-dependent membrane vesiculation and parasite killing induced by a cytotoxin fromPseudomonas aeruginosa." Parasitology 95, no. 2 (October 1987): 241–51. http://dx.doi.org/10.1017/s003118200005770x.
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SUMMARYWe have examined the interaction betweenSchistosoma mansoniand a cytotoxin fromPseudomonas aeruginosaknown to affect a variety of cell types through the formation of membrane pores. The killing effect of the cytotoxin onS. mansoni in vitrowas strongly dependent on the parasite developmental stage. Skin schistosomula were most sensitive, while 4-week-old or older parasites were less so. In contrast, lung schistosomula were relatively resistant and juvenile mesenteric forms younger than 28 days were almost completely refractory to the action of the toxin. A sharp increase in sensitivity to the toxin was observed between 27 and 28 days of parasite age with a parasite length of about 1·80 mm appearing as the threshold. Thus, the schistosome sensitivity to the cytotoxin changed during parasite development in a way similar to the known sensitivity of the worms toin vitroimmune attack. Killing of the parasites by the cytotoxin was preceded by the formation of vesicles which, in the case of adult worms, detached easily from the parasites. Evidence obtained by electron microscopy and by immunofluorescent assays with living worms demonstrated that the outer parasite membrane participated in the formation of the vesicle membrane. Thus, the cytotoxin may be a useful tracer for changes in the properties of the schistosome surface membrane during parasite development.
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Koene, J. M., and R. Chase. "Changes in the reproductive system of the snail Helix aspersa caused by mucus from the love dart." Journal of Experimental Biology 201, no. 15 (August 1, 1998): 2313–19. http://dx.doi.org/10.1242/jeb.201.15.2313.
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The function of the love dart in certain species of terrestrial snails is unknown. In Helix aspersa, the dart is a sharp calcareous structure that is used to pierce the partner's skin during courtship. When expelled, the dart is covered with a thick mucus. The hypothesis tested here is that the mucus contains a biologically active substance. Extracts of the digitiform glands that produce this mucus were applied to parts of the reproductive system in vitro. The extracts triggered an initial reconfiguration of the copulatory canal that caused the bursa tract diverticulum to become more accessible to the spermatophore. The reconfiguration of the copulatory canal also closed off the tract leading to the bursa copulatrix, a sperm-digesting organ. A few minutes after the initial contraction, the peristaltic contractions in the diverticulum became significantly more frequent. This latter effect continued for at least 1 h, provided that the mucus extract remained in the saline bath. The minimum effective dosage was less than the 2.2 mg of mucus transferred with the dart. Sperm competition is expected in Helix aspersa since multiple matings occur before eggs are laid. By influencing the female organs involved in the processing of foreign sperm, the dart shooter may increase the chance that his sperm will fertilise eggs.
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Fatmawati, Chusnul Nur, Ekowati Retnanin, and Tavip Dwi Wahyuni. "THE EFFECT OF ALOE VERA TOWARD THE NUMBER OF FIBROBLASTS ON THE WOUND INCISION OF WISTAR RAT’S (RATUS NORVEGICUS)." Journal of Vocational Nursing 1, no. 1 (May 29, 2020): 30. http://dx.doi.org/10.20473/jovin.v1i1.19905.
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Introduction: Incision is a wound caused by a sharp object, for example in surgery. The characteristics of the wound are pain, open wounds, and the length of the wound is greater than in it. Handling the wound there are various ways, one of which is using Aloe Vera. The aim of this study was to determine the effect of topical Aloe vera gel concentration of 10%, 20%, and 40% to determine the amount of fibroblast tissue in wistar strain rats (Rattus orvegicus) in incisions. Methods: This study uses an experimental design with a sample of 75 rats divided into 5 groups; 0.9% NaCl group, 1% tulle-framycetin sulfate group, 10% Aloe vera group, 20% Aloe vera group and 40% Aloe vera group. Samples of incisional wound skin were performed on days 3.7, and 12. All data were processed and analyzed statistically using SPSS 20. Based on microscopic observations at 10 times per field of view, the highest number of fibroblasts given at NaCl was given on the day 12th is 28.98 per field of view, treatment using tulle-framycetin sulfate 1% is 34.5 per field of view, treatment using Aloe vera 10% is 17.32 per field of view, treatment using Aloe vera 20% is 33, 9 per field of view while the treatment using Aloe vera was 40% ie 18.7 per view. Results : The results of the study with the Independent T-test and Paired T-test showed that the results of fibroblast tissue between 0.9% NaCl group, 1% tulle-framycetin sulfate, 10% Aloe vera, 40% Aloe vera with 20% Aloe vera there were differences which were significant (p <0.05) where 20% Aloe vera gave effective results in the wound healing process. Conclusion : This study concluded that 20% of Aloe vera can be used as an alternative choice of wound healing. In the next study it is expected to examine the variable TGF (Transforming Growth Factor) that affects cell growth in wound healing.
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Bruix, J., A. Cheng, Y. Kang, C. Tsao, S. Qin, G. Lentini, J. Zou, et al. "Effect of macroscopic vascular invasion (MVI), extrahepatic spread (EHS), and ECOG performance status (ECOG PS) on outcome in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib: Analysis of two phase III, randomized, double-blind trials." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 4580. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4580.
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4580^ Background: The landmark phase III SHARP trial (Llovet et al, N Engl J Med, 2008) showed that sorafenib is effective and safe for the treatment of advanced HCC. These results were confirmed in an Asian population in the phase III Asia-Pacific (AP) study (Cheng et al, Lancet Oncol, 2009). We compared outcomes of sorafenib treatment in patients enrolled in the SHARP and AP trials with known baseline predictors of poor prognosis. Methods: Patients with advanced, unresectable, measurable HCC, ECOG PS 0–2, Child-Pugh A, and no prior systemic therapy for HCC were randomized to sorafenib 400 mg BID or placebo (SHARP: N=602; AP: N=226). Patients in the AP study had more evolved disease and a predominance of hepatitis B infection. Endpoints included overall survival (OS), disease-control rate (DCR; defined as complete/partial response or stable disease by RECIST, maintained for ≥28 days from first demonstration of response), and safety. Results: Efficacy results are shown in the table . The incidence of grade 3/4 drug-related adverse events (AEs) across subgroups in each study was consistent with the overall population for each study. The most common grade 3/4 AEs in all sorafenib populations were hand-foot skin reaction and diarrhea. Conclusions: Sorafenib is effective and safe for the treatment of advanced HCC in patients globally, irrespective of baseline ECOG PS and presence or absence of MVI and/or EHS. [Table: see text] [Table: see text] ASCO Conflict of Interest Policy and Exceptions In compliance with the guidelines established by the ASCO Conflict of Interest Policy (J Clin Oncol. 2006 Jan 20;24[3]:519–521) and the Accreditation Council for Continuing Medical Education (ACCME), ASCO strives to promote balance, independence, objectivity, and scientific rigor through disclosure of financial and other interests, and identification and management of potential conflicts. According to the ASCO Conflict of Interest Policy, the following financial and other relationships must be disclosed: employment or leadership position, consultant or advisory role, stock ownership, honoraria, research funding, expert testimony, and other remuneration (J Clin Oncol. 2006 Jan 20;24[3]:520). The ASCO Conflict of Interest Policy disclosure requirements apply to all authors who submit abstracts to the Annual Meeting. For clinical trials that began accrual on or after April 29, 2004, ASCO's Policy places some restrictions on the financial relationships of principal investigators (J Clin Oncol. 2006 Jan 20;24[3]:521). If a principal investigator holds any restricted relationships, his or her abstract will be ineligible for placement in the 2009 Annual Meeting unless the ASCO Ethics Committee grants an exception. Among the circumstances that might justify an exception are that the principal investigator (1) is a widely acknowledged expert in a particular therapeutic area; (2) is the inventor of a unique technology or treatment being evaluated in the clinical trial; or (3) is involved in international clinical oncology research and has acted consistently with recognized international standards of ethics in the conduct of clinical research. NIH-sponsored trials are exempt from the Policy restrictions. Abstracts for which authors requested and have been granted an exception in accordance with ASCO's Policy are designated with a caret symbol (^) in the Annual Meeting Proceedings. For more information about the ASCO Conflict of Interest Policy and the exceptions process, please visit www.asco.org/conflictofinterest .
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Sarabahi, Sujata. "Recent advances in topical wound care." Indian Journal of Plastic Surgery 45, no. 02 (May 2012): 379–87. http://dx.doi.org/10.4103/0970-0358.101321.
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ABSTRACTThere are a wide variety of dressing techniques and materials available for management of both acute wounds and chronic non-healing wounds. The primary objective in both the cases is to achieve a healed closed wound. However, in a chronic wound the dressing may be required for preparing the wound bed for further operative procedures such as skin grafting. An ideal dressing material should not only accelerate wound healing but also reduce loss of protein, electrolytes and fluid from the wound, and help to minimize pain and infection. The present dictum is to promote the concept of moist wound healing. This is in sharp contrast to the earlier practice of exposure method of wound management wherein the wound was allowed to dry. It can be quite a challenge for any physician to choose an appropriate dressing material when faced with a wound. Since wound care is undergoing a constant change and new products are being introduced into the market frequently, one needs to keep abreast of their effect on wound healing. This article emphasizes on the importance of assessment of the wound bed, the amount of drainage, depth of damage, presence of infection and location of wound. These characteristics will help any clinician decide on which product to use and where,in order to get optimal wound healing. However, there are no ′magical dressings′. Dressings are one important aspect that promotes wound healing apart from treating the underlying cause and other supportive measures like nutrition and systemic antibiotics need to be given equal attention.
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Ibrahim, M. D., S. N. A. Amran, Y. S. Yunos, M. R. A. Rahman, M. Z. Mohtar, L. K. Wong, and A. Zulkharnain. "The Study of Drag Reduction on Ships Inspired by Simplified Shark Skin Imitation." Applied Bionics and Biomechanics 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/7854321.
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The skin of a fast swimming shark reveals riblet structures that help reduce the shark’s skin friction drag, enhancing its efficiency and speed while moving in the water. Inspired by the structure of the shark skin denticles, our team has carried out a study as an effort in improving the hydrodynamic design of marine vessels through hull design modification which was inspired by this riblet structure of shark skin denticle. Our study covers on macroscaled design modification. This is an attempt to propose an alternative for a better economical and practical modification to obtain a more optimum cruising characteristics for marine vessels. The models used for this study are constructed using computer-aided design (CAD) software, and computational fluid dynamic (CFD) simulations are then carried out to predict the effectiveness of the hydrodynamic effects of the biomimetic shark skins on those models. Interestingly, the numerical calculated results obtained show that the presence of biomimetic shark skin implemented on the vessels give about 3.75% reduction of drag coefficient as well as reducing up to 3.89% in drag force experienced by the vessels. Theoretically, as force drag can be reduced, it can lead to a more efficient vessel with a better cruising speed. This will give better impact to shipping or marine industries around the world. However, it can be suggested that an experimental procedure is best to be conducted to verify the numerical result that has been obtained for further improvement on this research.
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CHATTERJEE, KALIPADA. "Atmospheric ozone monitoring in the Indian network in view of possibility of damage to the biosphere due to distortion of ozone layer." MAUSAM 37, no. 4 (April 7, 2022): 471–82. http://dx.doi.org/10.54302/mausam.v37i4.2568.
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Atmospheric ozone protects life on the earth from harmful ultraviolet radiation of wavelengths in the biologically important 300nanometre region. In recent year many workers in the field of atmospheric ozone have brought out the various effects of oxides of nitrogen (NOx) Oxides of chlorine (CIOx) and Hydroxyl radicals (HOx) on the ozone layer due to man made activities. It has been demonstrated by recent studies that monsoon season these man made chemicals like NOx, ClOx released in the troposphere due to industrializations may eventually deplete ozone in the stratosphere by as much as 5% at the present rate of discharge of these chemicals in the lower troposphere. This depletion of total ozone could cause an increase in the incident of skin cancer. Furthermore these are indications of the possibility that plant life and marine life and other ecological systems are also affected cultural planning by the changes in ultraviolet radiation.
The ozone layer in the stratosphere controls the temperature & winds in the stratosphere and have a great influence in the general circulation & climate of the earth. Depletion of ozone in the stratosphere due to man made actitives, may therefore cause adverse effects on the earth’s climate. Model calculation indicate that early next Century the combined radiative effects of ozone and other trace gases would be of the same order as that calculated for CO2.
Recent studies in the field of tropospheric ozone have indicated that due to man made activities possibility of sharp increase in the tropospheric ozone particularly in the industrially developed countries. This increase in the tropospheric ozone could adversely effect human health and plant life particularly forest resources.
It has, therefore, become very important to accurately monitor atmospheric ozone on a routine and network basis over the entire globe by insitu, balloon borne and satellite measurements. The present paper brings out the results and analysis of total ozone, vertical ozone measurements by Umkehr and balloon sonde and tropospheric ozone measurements by ground based and balloon borne sondes made in the Indian network during the last decade (1970-1979) and various aspects of ozone profiles and variations and ozone trend analysis over the years have been presented and discussed in this paper.
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Rakhmanin, Yu A., N. A. Egorova, G. N. Krasovsky, R. I. Mikhailova, and A. V. Alekseeva. "SILICON: ITS BIOLOGICAL IMPACT UNDER DIETARY INTAKE AND HYGIENIC STANDARDIZATION OF ITS CONTENT IN DRINKING WATER. A REVIEW." Hygiene and sanitation 96, no. 5 (March 27, 2019): 492–98. http://dx.doi.org/10.18821/0016-9900-2017-96-5-492-498.
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By the prevalence in the earth’s crust, silicon occupies the second place after oxygen. In different quantities silicon always presents in water and food products.The average daily dietary intake of silicon in Western world is about 20-50 mg/day. The biological role of silicon in human organism is still not clear, but it assumed to be necessary for processes of bone mineralization, collagen synthesis, it has a positive effect on the state of skin, hair, and nails, contributes to the prevention of atherosclerosis and Alzheimer disease. A number of scientific research is devoted to biological effects of silicon in animals and human subjects under intake with food and water, and substantiation of silicon (maximum admissible concentrations (MAC) in drinking water. In Chuvashia there was investigated the regional (geographical) pathology, which may be related with an increased silicon intake in association with the sharp imbalances of trace and macro elements in drinking water. Some measures were implemented to identify the possible role of silicon in etiology of Balkan endemic nephropathy. Organization for Economic Co-operation and Development (OECD) report summarized materials for the experimental evaluation of the toxicity and harmless levels of silicon intake with food and water in animals. A series of studies was executed to simulate the development of silicon urolithiasis and for the elucidation of the role of macro- and microelements accompanying the intake of silicon into the body in stone formation. There are studied potential therapeutic effects of water soluble silicon compounds on human health. The standards of silicon in drinking water are regulated only in Russia and Australia. At the same time in our country there were formed two opposing points of view in relation to the hygienic standardization of silicon. The first is one - MAC of silicon in drinking water needs to be cancelled, the second - MAC of silicon in the water needs to be tightened. To resolve the contradictions it is advisable to use both the experience of harmonization of standards with international requirements, and the principle of silicon regional standardization, taking into consideration the biogeochemical characteristics of geographic areas. When searching the literature databases PubMed and CyberLeninka were used.
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Hoffmann-Vold, A. M., D. Huscher, P. Airò, E. Zanatta, P. Carreira, Y. Allanore, U. Müller-Ladner, et al. "POS0316 MODELLING SHORT-TERM FVC CHANGES FROM SENSCIS TO LONG-TERM FVC COURSE IN SSc-ILD DEMONSTRATES CLINICALLY MEANINGFUL REDUCTION OF FVC DECLINE AND SURVIVAL BENEFITS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 384–85. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2522.
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Background:Nintedanib has shown to slow FVC decline by 41ml over 52 weeks in systemic sclerosis-associated interstitial lung disease (SSc-ILD). However, the long-term effect of nintedanib treatment on ILD progression and mortality in SSc patients is so far unknown.Objectives:Here, the 52-week treatment efficacy of nintedanib was modeled and extrapolated on the long-term FVC course and survival in SSc-ILD patients from the European Scleroderma Trial and Research (EUSTAR) database.Methods:SSc patients from the EUSTAR database fulfilling the inclusion criteria of the SENSCIS trial (SSc classification criteria, ILD confirmed by imaging, disease duration of <7 years, FVC≥40%pred, diffusion capacity of the lung for carbon monoxide (DLCO) 30-89%pred); and matched for baseline characteristics as well as matched for the 52-week FVC change of SENSCIS patients were included (n=236). Linear mixed models including time, risk factors at baseline (sex, age, dyspnea class, DLCO%, CRP, modified Rodnan skin score, SSc subtype, SSc auto-antibodies, disease duration, synovitis and muscle weakness) were used to estimate the natural FVC course over time. On this natural course of FVC, the observed effect from the SENSCIS trial representing the absolute 52-week difference of FVC decline between the nintedanib and the placebo group was applied as continuous annual effect (SENSCIS effect model). Survival was estimated for both the natural course as well as the SENSCIS effect model using Cox regression.Results:Of the 236 included patients, 75% were females, 65% had diffuse cutaneous SSc. Mean age was 50.6 years, mean FVC 78.2%pred and DLCO 56.3%pred at time of inclusion. Mean FVC change after 12±3 months was -2.3 ±6.9%pred. These parameters were largely similar to the characteristics of the SENSCIS population.In the longitudinal follow up of this population, the natural course of FVC showed a total FVC decline of -16.3%pred over 5 years. With assumed SENSCIS effects (effects of nintedanib treatment reported in SENSCIS), the 5-year FVC decline was reduced to -10.3%pred (Figure 1).The reduced FVC progression translated into an improved survival. The natural 5-year survival of this SSc-ILD population was 88.2%. When extrapolating also a severe FVC decline early in the course, frequently terminated by early mortality of SSc patients excluding them from long-term outcome assessment, the estimated 5-year survival was reduced to 81.6%. When the SENSCIS effects on FVC were considered, the 5-year extrapolated survival was increased to 86.3% (Figure 2).Conclusion:Long-term experience of nintedanib treatment in SSc-ILD patients is lacking so far, therefore we modeled and extrapolated the 52-week treatment efficacy of nintedanib on the long-term FVC course and survival in SSc-ILD patients from the EUSTAR database. We could demonstrate a significant reduction of FVC decline by extrapolating the annual treatment effects of nintedanib from the SENSCIS trial from 1 to 5 years in EUSTAR. Translating these reductions of FVC decline into survival, the 5-year mortality rate was reduced from 18% to 13%.Disclosure of Interests:Anna-Maria Hoffmann-Vold Speakers bureau: Boehringer Ingelheim, Actelion, Roche, Merck Sharp & Dohme, Lilly, Consultant of: Actelion, Boehringer Ingelheim, Roche, Bayer, Merck Sharp & Dohme, ARXX, Lilly and Medscape, Grant/research support from: Boehringer Ingelheim, Dörte Huscher: None declared, Paolo Airò Speakers bureau: Boehringer Ingelheim, Consultant of: Bristol-Myers-Squibb, Novartis, Elisabetta Zanatta Speakers bureau: Boehringer Ingelheim, Actelion, GSK, Paid instructor for: GSK, Consultant of: Boehringer Ingelheim, GSK, Patricia Carreira Speakers bureau: Actelion, Boehringer Ingellheim, Janssen, GSK, Paid instructor for: Boehringer Ingelheim, Consultant of: AbbVie, Boehringer Ingelheim, VivaCell, Emerald Health Pharmaceuticals, Gesynta Pharma, Sanofi Genzyme, Grant/research support from: Roche, GSK, Yannick Allanore Consultant of: Honorarium received from Boehringer, MedsenicSanofi, Menarini, Grant/research support from: Grants received from Alpine, Ose Immunogenetics, Ulf Müller-Ladner Speakers bureau: Boehringer Ingelheim, Consultant of: Boehringer Ingelheim, Alessandro Giollo: None declared, Maria Rosa Pozzi: None declared, CAROLINA SOUZA MULLER Speakers bureau: Boehinger Ingelheim, Janssen, Roche, LIBBS, Bristol-Myers-Squib, Radim Bečvář Consultant of: Actelion, Boehringer Ingelheim, Michele Iudici: None declared, Dominik Majewski Speakers bureau: Boehringer Ingelheim - 2 x paid as a speaker, Armando Gabrielli Grant/research support from: Pfizer, CSL Behring, Margarida Alves Employee of: Boehringer Ingelheim, Nils Schoof Employee of: Boehringer Ingelheim International GmbH, Oliver Distler Speakers bureau: Boehringer Ingelheim, Medscape, IQone, Roche, Consultant of: Abbvie, Acceleron Pharma, Amgen, AnaMar, Arxx Therapeutics, Baecon Discovery, Blade Therapeutics, Bayer, Boehringer Ingelheim, ChemomAb, Corbus Pharmaceuticals, CSL Behring, Galapagos NV, Glenmark Pharmaceuticals, GSK, Horizon (Curzion) Pharmaceuticals, Inventiva, iQvia, Italfarmaco, Kymera Therapeutics, Lilly, Medac, Mitsubishi Tanabe Pharma, MSD, Novartis, Pfizer, Roche, Sanofi, Serodapharm, Topadur, Target Bioscience and UCB, Grant/research support from: Kymera Therapeutics, Mitsubishi Tanabe
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Luo, Yue Hao, and De Yuan Zhang. "Study on the Micro-Replication Precision of Shark Skin." Applied Mechanics and Materials 44-47 (December 2010): 1151–57. http://dx.doi.org/10.4028/www.scientific.net/amm.44-47.1151.
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The biomimetic highly-efficient drag reduction surface can be directly replicated by shark skin as biological template, and the pre cured micro-embossing technology is put forward aiming at the thermosetting materials. In the process of bio-replicated forming, the replication precision is one of the most important factors in evaluating the forming effect, and the convincing and reliable assessing method has become an urgent problem to be solved. In this paper, the new evaluating way on the basis of statistical method is put into application, which provide the new idea and method to study the forming quality and effect, and the replication-precision of single scale and regional scales is in comprehensive and deep analysis. In addition, the factors causing forming errors are also illustrated and discussed, which lay the foundation for further research.
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Han, Xin, and Juan Wang. "A Novel Method for Fabrication of the Biomimetic Shark-Skin Coating." Advanced Materials Research 239-242 (May 2011): 3014–17. http://dx.doi.org/10.4028/www.scientific.net/amr.239-242.3014.
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The shark-skin effect motivated from the dermal surface morphology of sharks hastens the imitation and manufacture of the non-smooth drag reduction bionic coating based on shark skin. The fabrication of the bionic shark-skin coating with life-sized scale-like microstructure was presented in this paper. Using hot embossing technology, the direct micro replication of the microstructure on shark skin was investigated for the first time. Modeled after the shark skin sample, the negative structure was directly replicated and printed on PMMA flat plate in the hot embossing process, relied on which the bionic shark-skin coating made of silica gel was fabricated in the end. The preliminary experiment results indicate that this method is a high precision, high throughput, high efficiency and low cost way to fabricate bionic microstructure in micron and submicron scale with good repeatability and availability.
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Ramachandran, Rahul, Nazanin Maani, Vitaliy L. Rayz, and Michael Nosonovsky. "Vibrations and spatial patterns in biomimetic surfaces: using the shark-skin effect to control blood clotting." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2073 (August 6, 2016): 20160133. http://dx.doi.org/10.1098/rsta.2016.0133.
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We study the effect of small-amplitude fast vibrations and small-amplitude spatial patterns on various systems involving wetting and liquid flow, such as superhydrophobic surfaces, membranes and flow pipes. First, we introduce a mathematical method of averaging the effect of small spatial and temporal patterns and substituting them with an effective force. Such an effective force can change the equilibrium state of a system as well as a phase state, leading to surface texture-induced and vibration-induced phase control. Vibration and patterns can effectively jam holes in vessels with liquid, separate multi-phase flow, change membrane properties, result in propulsion and locomotion and lead to many other multi-scale, nonlinear effects including the shark-skin effect. We discuss the application of such effects to blood flow for novel biomedical ‘haemophobic’ applications which can prevent blood clotting and thrombosis by controlling the surface pattern at a wall of a vessel (e.g. a catheter or stent). This article is part of the themed issue ‘Bioinspired hierarchically structured surfaces for green science’.
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Schaaf, P., H. Schikora, D. Höche, C. Lange, V. Drescher, and J. Wilden. "Laser clad surfaces for shark-skin effect by high-temperature activation." Surface and Coatings Technology 203, no. 5-7 (December 2008): 470–75. http://dx.doi.org/10.1016/j.surfcoat.2008.08.066.
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Kesel, A., and R. Liedert. "Learning from nature: Non-toxic biofouling control by shark skin effect." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 146, no. 4 (April 2007): S130. http://dx.doi.org/10.1016/j.cbpa.2007.01.246.
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Wheeler, Andrew P. S., and Richard D. Sandberg. "Numerical investigation of the flow over a model transonic turbine blade tip." Journal of Fluid Mechanics 803 (August 17, 2016): 119–43. http://dx.doi.org/10.1017/jfm.2016.478.
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Direct numerical simulations (DNS) are used to investigate the unsteady flow over a model turbine blade tip at engine-scale Reynolds and Mach numbers. The DNS are performed with an in-house multiblock structured compressible Navier–Stokes solver. The particular case of a transonic tip flow is studied since previous work has suggested that compressibility has an important effect on the turbulent nature of the separation bubble at the inlet to the tip–casing gap and subsequent flow reattachment. The flow is simulated over an idealized tip geometry where the tip gap is represented by a constant-area channel with a sharp inlet corner to represent the pressure side edge of the turbine blade. The effects of free-stream disturbances, cross-flow and the pressure side boundary layer on the tip flow aerodynamics and heat transfer are studied. For ‘clean’ inflow cases we find that even at engine-scale Reynolds numbers the tip flow is intermittent in nature, i.e. neither laminar nor fully turbulent. The breakdown to turbulence occurs through the development of spanwise streaks with wavelengths of approximately 15 %–20 % of the gap height. Multidimensional linear stability analysis confirms the two-dimensional base state to be most unstable with respect to spanwise wavelengths of 25 % of the gap height. The linear stability analysis also shows that the addition of cross-flows with 25 % of the streamwise gap exit velocity increases the stability of the tip flow. This is confirmed by the DNS, which also show that the turbulence production is significantly reduced in the separation bubble. For the case when free-stream disturbances are added to the inlet flow, viscous dissipation and the rapid acceleration of the flow at the inlet to the tip–casing gap cause significant distortion of the vorticity field and reductions of turbulence intensity as the flow enters the tip gap. The DNS results also suggest that the assumption of the Reynolds analogy and a constant recovery factor are not accurate, in particular in regions where the skin friction approaches zero while significant temperature gradients remain, such as in the vicinity of flow reattachment.
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Huang, Meineng, Sheng Jiang, Tong Chen, Xu Han, Xinyu Yang, Zhizen Quan, Yang Yuan, et al. "Preparation and Evaluation of the Curative Effect of Blue Shark (Prionace glauca) Skin Collagen Composite Gel in a Rat Oral Ulcers Model." Journal of Biomaterials and Tissue Engineering 11, no. 10 (October 1, 2021): 1924–31. http://dx.doi.org/10.1166/jbt.2021.2787.
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Objective: To evaluate the curative effect of blue shark skin collagen composite gel on oral mucosal ulcer using the rat oral ulcers model stimulated by glacial acetic acid. Methods: Collagen from blue shark skin was isolated and physiochemically characterized by FTIR, SDS-PAGE and scanning electron microscopy (SEM). Seventy standard male rats were divided into seven groups. The surface and the area of the ulcer were observed and calculated daily. After 12 days of administration, rats in the model group and the control group were killed and the ulcer and surrounding tissues were cut to pieces about one mm3 size. The specimens were stained with 10% formalin solution, paraffinembedded sections, HE staining and light microscope were used to observe the histopathological changes in ulcer tissues. Results: The high-dose group had the fastest ulcer healing effects after 12 days of treatment with blue shark skin collagen composite gel. The composite gel was found to significantly accelerate the healing of oral ulcers in a dose-dependent manner. Conclusion: The blue shark skin collagen composite gel in this study may be a good biomedical material candidate for the treatment of oral ulcers in the near future. Potential of other marine fish skin collagen comples on healing oral ulcers should be also considered.
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Peyronnel, C., V. Petitcolin, P. Totoson, H. Martin, F. Verhoeven, and C. Demougeot. "SAT0021 STRUCTURAL EFFECTS OF LOCAL CRYOTHERAPY IN RHEUMATOID ARTHRITIS: A STUDY IN ADJUVANT-INDUCED ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 940.2–941. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4118.
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Background:The control of joint destruction caused by rheumatoid arthritis (RA) is a key issue in the treatment of this disease. Recent evidence showed that radiographic progression of joint damage occur despite a sharp decrease in disease activity and the use of aggressive Disease Modifying Anti-Rheumatic Drug (DMARD) therapies [1]. Whether alternative treatments such as cryotherapy may have beneficial effects on joint destruction at the early stages of the disease remains to be demonstrated, but such strategy would be of interest as it would not interfere with DMARDs treatment.Objectives:The aim of this study was to evaluate the effect of a 14-days-treatment of local cryotherapy on radiological outcomes in rat adjuvant induced arthritis.Methods:Adjuvant-induced arthritis (AIA) was induced in 6-weeks old male Lewis rats by injection ofMycobacterium butyricumin Freund’s incomplete adjuvant at the basis of the tail. A control group received saline. At the onset of arthritis, AIA rats were treated or not by application of cryotherapy on paws using either a cold spray or ice, twice a day for 14 days. Arthritis score and paws skin temperature was daily monitored. At the end of treatment, radiological exam of hind paws was performed and a score taking into account (swelling, osteoporosis, cartilage destruction, bone erosion, bone destruction and new bone formation) was assigned, according to Ackermanet al[2]. Circulating levels of cytokines (IL-6, IL-1β, TNF-α) was measured by Magpix Luminex kit.Results:Compared to untreated AIA, local cryotherapy significantly reduced the progression of arthritis score, whatever the modality (p<0.05), and to the same extent (reduction of arthritis score at day 24 post-immunization: -38% with cold spray, p<0.01, -37% with ice, p<0.01). Radiological score was significantly reduced by both treatments with no difference between the two treatments (-33% with cold spray, p<0.01, -44% with ice, p<0.01). All the items of the radiological score were equally reduced by ice and cold spray except swelling that was significantly reduced only by ice. Interestingly, the use of the cold spray induced a greater decrease in the skin temperature than the ice treatment (18.32 ± 0.07 °C vs 20.46 ± 0.08 °C, p<0.001). Conversely, cryotherapy did not significantly change the level of cytokines. No correlation was found between radiological score and arthritis score or cytokine levels.Conclusion:These data demonstrated that local cryotherapy had positive effects on structural damage in adjuvant-induced arthritis. The mechanisms involved remain now to be determined. These results suggest that local cryotherapy would be an interesting complement to conventional DMARDs in early RA.References:[1] Ten Klooster, P. M.et al.Radiographic progression can still occur in individual patients with low or moderate disease activity in the current treat-to-target paradigm: real-world data from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry.Arthritis Res. Ther.21, 237 (2019).[2] Ackerman, N. R.et al.Effects of naproxen on connective tissue changes in the adjuvant arthritic rat.Arthritis Rheum.22, 1365–1374 (1979).Disclosure of Interests:Célian Peyronnel: None declared, Valentin Petitcolin: None declared, Perle Totoson: None declared, Hélène Martin: None declared, Frank Verhoeven: None declared, Céline Demougeot Grant/research support from: With an institutional support from Pfizer.
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Domel, August G., Mehdi Saadat, James C. Weaver, Hossein Haj-Hariri, Katia Bertoldi, and George V. Lauder. "Shark skin-inspired designs that improve aerodynamic performance." Journal of The Royal Society Interface 15, no. 139 (February 2018): 20170828. http://dx.doi.org/10.1098/rsif.2017.0828.
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There have been significant efforts recently aimed at improving the aerodynamic performance of aerofoils through the modification of their surfaces. Inspired by the drag-reducing properties of the tooth-like denticles that cover the skin of sharks, we describe here experimental and simulation-based investigations into the aerodynamic effects of novel denticle-inspired designs placed along the suction side of an aerofoil. Through parametric modelling to query a wide range of different designs, we discovered a set of denticle-inspired surface structures that achieve simultaneous drag reduction and lift generation on an aerofoil, resulting in lift-to-drag ratio improvements comparable to the best-reported for traditional low-profile vortex generators and even outperforming these existing designs at low angles of attack with improvements of up to 323%. Such behaviour is enabled by two concurrent mechanisms: (i) a separation bubble in the denticle's wake altering the flow pressure distribution of the aerofoil to enhance suction and (ii) streamwise vortices that replenish momentum loss in the boundary layer due to skin friction. Our findings not only open new avenues for improved aerodynamic design, but also provide new perspective on the role of the complex and potentially multifunctional morphology of shark denticles for increased swimming efficiency.
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Liu, Yunhong, and Guangji Li. "A new method for producing “Lotus Effect” on a biomimetic shark skin." Journal of Colloid and Interface Science 388, no. 1 (December 2012): 235–42. http://dx.doi.org/10.1016/j.jcis.2012.08.033.
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Wen, Li, James C. Weaver, Patrick J. M. Thornycroft, and George V. Lauder. "Hydrodynamic function of biomimetic shark skin: effect of denticle pattern and spacing." Bioinspiration & Biomimetics 10, no. 6 (November 18, 2015): 066010. http://dx.doi.org/10.1088/1748-3190/10/6/066010.
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Distler, O., F. Kramer, J. Höfler, M. Ghadessi, P. Sandner, Y. Allanore, C. Denton, et al. "FRI0575 BIOMARKER ANALYSIS FROM THE RISE-SSC STUDY OF RIOCIGUAT IN EARLY DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS (DCSSC)." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 890–91. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3138.
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Background:RISE-SSc (NCT02283762) was a multicenter, double-blind, Phase IIb study of riociguat in early dcSSc. Primary endpoint was change in mRSS from baseline to Wk 52.Objectives:Exploratory, descriptive analyses of riociguat target engagement and effects on disease biomarkers in RISE-SSc and their relationship with effects on the primary endpoint. All biomarker p-values are for information only.Methods:Pts with dcSSc (duration ≤18 mo; modified Rodnan skin score [mRSS] 10–22 units) were randomized to riociguat 0.5−2.5 mg tid (n=60) or placebo (n=61). Biomarkers of target engagement (cGMP), inflammation and/or vascular/endothelial function (e.g. high-sensitivity C-reactive protein [hsCRP], soluble platelet endothelial cell adhesion molecule 1 [sPECAM-1], soluble E-selectin, chemokine ligand 4 [CXCL-4]), and fibrosis (e.g. alpha-smooth muscle cell actin [alphaSMA], pro-collagen mRNA expression) were measured in plasma, serum, and skin biopsies at baseline and Wk 14.Results:Mean±SD change from baseline in mRSS was –2.09±5.66 (n=57) with riociguat and –0.77±8.24 (n=52) with placebo (p=0.08). From baseline to Wk 14, plasma cGMP rose by mean (SD) 94% (78%) (n=52) with riociguat and 10% (39%) (n=52) with placebo (nominal p<0.001). Serum sPECAM-1 and CXCL-4 fell with riociguat vs placebo; changes in hsCRP or E-selectin differed little between groups (Fig 1). Pts with higher baseline sPECAM-1 showed larger mRSS reductions with riociguat vs placebo than pts with lower levels (nominal interaction p=0.004). In baseline skin biopsies, 34% and 31% of pts in the riociguat and placebo groups, respectively, had no alphaSMA-positive cells; other pts had +ve cells (alphaSMA counts 0.1–99.5, median 2.5), a potential indicator of higher disease activity. Pts with +ve baseline alphaSMA counts showed a reduction of mRSS with riociguat vs placebo (Fig 2). Skin collagen mRNA expression biomarkers in skin biopsies showed no differences between groups.Conclusion:Primary study endpoint (change in mRSS) was not met. Plasma cGMP rose with riociguat, confirming engagement with the NO-sGC-cGMP pathway. Serum sPECAM-1 (marker of endothelial activation) and CXCL-4 (marker of progressive SSc) fell with riociguat; hsCRP and E-selectin did not. Some serum and skin biomarkers of higher disease activity at baseline were associated with a greater effect of riociguat on skin fibrosis.Acknowledgments:RISE-SSc was jointly funded by Bayer AG and Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.Disclosure of Interests:Oliver Distler Grant/research support from: Grants/Research support from Actelion, Bayer, Boehringer Ingelheim, Competitive Drug Development International Ltd. and Mitsubishi Tanabe; he also holds the issued Patent on mir-29 for the treatment of systemic sclerosis (US8247389, EP2331143)., Consultant of: Consultancy fees from Actelion, Acceleron Pharma, AnaMar, Bayer, Baecon Discovery, Blade Therapeutics, Boehringer, CSL Behring, Catenion, ChemomAb, Curzion Pharmaceuticals, Ergonex, Galapagos NV, GSK, Glenmark Pharmaceuticals, Inventiva, Italfarmaco, iQvia, medac, Medscape, Mitsubishi Tanabe Pharma, MSD, Roche, Sanofi and UCB, Speakers bureau: Speaker fees from Actelion, Bayer, Boehringer Ingelheim, Medscape, Pfizer and Roche, Frank Kramer Employee of: Bayer AG, Josef Höfler Employee of: Josef Höfler is an employee of Staburo GmbH, Munich, Germany, contracted by Bayer AG to perform the biomarker analyses, Mercedeh Ghadessi Employee of: Bayer AG, Peter Sandner Employee of: Bayer AG, Yannick Allanore Grant/research support from: BMS, Inventiva, Roche, Sanofi, Consultant of: Actelion, Bayer AG, BMS, BI, Christopher Denton Grant/research support from: GlaxoSmithKline, CSL Behring, and Inventiva, Consultant of: Medscape, Roche-Genentech, Actelion, GlaxoSmithKline, Sanofi Aventis, Inventiva, CSL Behring, Boehringer Ingelheim, Corbus Pharmaceuticals, Acceleron, Curzion and Bayer, Masataka Kuwana Grant/research support from: Acetelion, Consultant of: Acetelion, Bayer, Chugai, Corbus Pharmaceuticals, CSL Behring and Reata Pharmaceuticals. He was a member of the SENSCIS trial Steering Committee (Boehringer Ingelheim), Marco Matucci-Cerinic Grant/research support from: Actelion, MSD, Bristol-Myers Squibb, Speakers bureau: Acetelion, Lilly, Boehringer Ingelheim, Janet Pope Grant/research support from: AbbVie, Bristol-Myers Squibb, Eli Lilly & Company, Merck, Roche, Seattle Genetics, UCB, Consultant of: AbbVie, Actelion, Amgen, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Eicos Sciences, Eli Lilly & Company, Emerald, Gilead Sciences, Inc., Janssen, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi, UCB, Speakers bureau: UCB, Tatsuya Atsumi Grant/research support from: Eli Lily Japan K.K., Alexion Pharmaceuticals, Inc., Bristol-Myers Squibb Co., AbbVie Inc., Daiichi Sankyo Co., Ltd., Pfizer Inc., Chugai Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co., Astellas Pharma Inc., Consultant of: Gilead Sciences, Inc., Eli Lilly Japan K.K., UCB Japan Co. Ltd., AbbVie Inc., Daiichi Sankyo Co., Ltd., Pfizer Inc., Chugai Pharmaceutical Co., Ltd., Speakers bureau: Eli Lilly Japan K.K., UCB Japan Co. Ltd., Bristol-Myers Squibb Co., AbbVie Inc., Eisai Co. Ltd., Otsuka Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd., Pfizer Inc., Chugai Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co., Takeda Pharmaceutical Co., Ltd., Astellas Pharma Inc., Radim Bečvář Consultant of: Actelion, Roche, László Czirják Consultant of: Actelion, BI, Roche-Genentech, Lilly, Medac, Novartis, Pfizer, Bayer AG, Ellen De Langhe Consultant of: member of advisory board for Boehringer, Eric Hachlla: None declared, Tomonori Ishii: None declared, Osamu Ishikawa: None declared, Sindhu Johnson Grant/research support from: Boehringer Ingelheim, Corbus Pharmaceuticals, GlaxoSmithKline, Roche, Merck, Bayer, Consultant of: Boehringer Ingelheim, Ikaria, Kaisa Laapas Employee of: Partly in-sourced to Bayer, Valeria Riccieri: None declared, Elena Schiopu: None declared, Richard Silver: None declared, Vanessa Smith Grant/research support from: The affiliated company received grants from Research Foundation - Flanders (FWO), Belgian Fund for Scientific Research in Rheumatic diseases (FWRO), Boehringer Ingelheim Pharma GmbH & Co and Janssen-Cilag NV, Consultant of: Boehringer-Ingelheim Pharma GmbH & Co, Speakers bureau: Actelion Pharmaceuticals Ltd, Boehringer-Ingelheim Pharma GmbH & Co and UCB Biopharma Sprl, Chiara Stagnaro: None declared, Viginia Steen Grant/research support from: The associated affiliation has received grants/research from Boehringer Ingelheim, Corbus Pharmaceuticals, CSL Behring, Eicos, Galapagos, Immune Tolerance Network, Reata, Consultant of: Virginia Steen has acted as a consultant for Boehringer Ingelheim, Corbus, CSL Behring, Eicos, Forbius, Wendy Stevens: None declared, Gabriella Szücs: None declared, Marie-Elise Truchetet: None declared, Melanie Wosnitza Employee of: Bayer AG, Dinesh Khanna Shareholder of: Eicos Sciences, Inc./Civi Biopharma, Inc., Grant/research support from: Dr Khanna was supported by NIH/NIAMS K24AR063120, Consultant of: Acceleron, Actelion, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Corbus Pharmaceuticals, Horizon Therapeutic, Galapagos, Roche/Genentech, GlaxoSmithKline, Mitsubishi Tanabe, Sanofi-Aventis/Genzyme, UCB
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Chen, Huawei, Xin Zhang, Da Che, Deyuan Zhang, Xiang Li, and Yuanyue Li. "Synthetic Effect of Vivid Shark Skin and Polymer Additive on Drag Reduction Reinforcement." Advances in Mechanical Engineering 6 (January 2014): 425701. http://dx.doi.org/10.1155/2014/425701.
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Domel, August G., Gino Domel, James C. Weaver, Mehdi Saadat, Katia Bertoldi, and George V. Lauder. "Hydrodynamic properties of biomimetic shark skin: effect of denticle size and swimming speed." Bioinspiration & Biomimetics 13, no. 5 (August 2, 2018): 056014. http://dx.doi.org/10.1088/1748-3190/aad418.
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Li, Xiang, Jun Cai, and De Yuan Zhang. "Study on the Manufacturing Method of the Biomimetic Drag Reducing Morphology Replication Mold." Advanced Materials Research 97-101 (March 2010): 2533–37. http://dx.doi.org/10.4028/www.scientific.net/amr.97-101.2533.
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In order to manufacture the drag reducing morphology replication mold used for biomimetic drag reducing film fabrication, the real shark skin and micro riblets machined with ultrasonic elliptical vibration cutting (UEVC) were used as templates respectively, followed by the casting process. The manufacturing process and the morphology quality of the molds was studied, and the biomimetic drag reducing effect and suitable application field was analyzed. The result indicates that: the bio-replicated forming mold based on shark skin is superior in morphology similarity with the real shark skin; the UEVC mold can achieve simplified riblets with high quality, and is feasible for large area mold manufacture and riblets spacing adjustment. The riblets morphology made with UEVC has wider application field than the shark shin morphology because of its flexibility of spacing adjustment.
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Stadnychenko, A. P., O. I. Uvaieva, and G. Ye Kyrychuk. "SYMPTOMS OF POISONING LYMNAEA (MOLLUSCA, GASTROPODA, LYMNAEIDAE) WITH WATER MEDIUM CHROME SULFATE." Odesa National University Herald. Biology 26, no. 1(48) (July 5, 2021): 89–101. http://dx.doi.org/10.18524/2077-1746.2021.1(48).232855.
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Problem. Cr (III) ions are dangerously toxic for the hydrobionts of water system of the Dnieper River basin. The ions have not been previously studied in relation to their effect on a number of pond snail species. Aim. Hence, the aim of this work is to determine the range of concentrations of Cr (III) in aquatic environment that cause each of the subsequent phases of pathological process in pond snails: poisoning by the aforementioned toxicant, and presence of the complexes of symptoms of the pathological or adaptive nature that are typical for each phase. Methods.The study was conducted in 2018 in the laboratory of zoology of invertebrates of Zhytomyr Ivan Franko State University on 344 individuals of pond snails of the species Lymnaea atra, L. callomphala and L. turricula. The toxicological experiment was performed according to the technique of V. A. Alekseyev, the rate of heartbeat by D. A. Vyskushenko, the rate of branchial respiration by V. I. Zhadin, the mean daily food intake by A. P. Sushkina, the trematode (Trematoda) infection rates and morphological examination by T. A. Ginetsinskaya. Main results. Cr (III) ions are water-soluble endogenic, highly poisonous toxicant, which locally affects the respiratory branchial epithelium and skin epithelium of pond snails. The depression, and later the termination of aerobic respiration lead to their death from asphyxia. The course of poisoning is five-phase. At 0.5 MPC Cr (III) all vital functions of pond snails are carried out at the normal level (indifference phase). At concentrations of 1-2 MPC, Cr (III) ions cause an increase in their heart rate, intensity of branchial respiration, nutrition and digestion, locomotion (muscle) activity (stimulation phase). At 3 MPC of Cr (III) ions, the depression phase of intoxication develops, with the complex of symptoms including bradycardia, a sharp weakening of respiratory and trophic functions and muscle activity, with increasing degrees of hydremia, pastosity, necrosis of the respiratory epithelium and underlying tissues, and the occurrence of bleeding and hemorrhage (depressive, sublethal and lethal phases). Conclusions. The studied species of pond snails are highly sensitive to the action of Cr (III) ions and can be suggested for use as test objects in the system of hydroecological monitoring of terrestrial waters of Ukraine.
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Du Clos, Kevin T., Amy Lang, Sean Devey, Philip J. Motta, Maria Laura Habegger, and Brad J. Gemmell. "Passive bristling of mako shark scales in reversing flows." Journal of The Royal Society Interface 15, no. 147 (October 2018): 20180473. http://dx.doi.org/10.1098/rsif.2018.0473.
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Shark skin has been shown to reduce drag in turbulent boundary layer flows, but the flow control mechanisms by which it does so are not well understood. Drag reduction has generally been attributed to static effects of scale surface morphology, but possible drag reduction effects of passive or active scale actuation, or ‘bristling’, have been recognized more recently. Here, we provide the first direct documentation of passive scale bristling due to reversing, turbulent boundary layer flows. We recorded and analysed high-speed videos of flow over the skin of a shortfin mako shark, Isurus oxyrinchus . These videos revealed rapid scale bristling events with mean durations of approximately 2 ms. Passive bristling occurred under flow conditions representative of cruise swimming speeds and was associated with two flow features. The first was a downward backflow that pushed a scale-up from below. The second was a vortex just upstream of the scale that created a negative pressure region, which pulled up a scale without requiring backflow. Both flow conditions initiated bristling at lower velocities than those required for a straight backflow. These results provide further support for the role of shark scale bristling in drag reduction.
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Limpisophon, Kanokrat, Hitomi Iguchi, Munehiko Tanaka, Toru Suzuki, Emiko Okazaki, Toshiki Saito, Kigen Takahashi, and Kazufumi Osako. "Cryoprotective effect of gelatin hydrolysate from shark skin on denaturation of frozen surimi compared with that from bovine skin." Fisheries Science 81, no. 2 (December 25, 2014): 383–92. http://dx.doi.org/10.1007/s12562-014-0844-5.
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Kosovac, Olga, B. Zivkovic, Cedomir Radovic, G. Marinkov, D. Tomasevic, N. Delic, and S. Pejcic. "Contribution to the knowledge of the effect of back fat thickness on quality of carcass of Swedish landrace pigs." Biotehnologija u stocarstvu 23, no. 1-2 (2007): 59–70. http://dx.doi.org/10.2298/bah0702059k.
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In this paper a comparative research relating to evaluation of the quality of pig carcasses originating from Swedish Landrace was carried out, total of 248 fatteners divided into two groups depending on the back fat thickness on withers and back. Quality was determined by partial dissection of left carcass sides according to procedure recommended by EU. The effect of back fat thickness on withers and back on quality of carcass sides, i.e. its effect on the share of muscle tissue, skin with subcutaneous fat tissue and intermuscular fat tissue in carcass side, was investigated. Obtained data show that exhibited difference in meat yield between groups wasn't statistically significant (P>0,05) in any of the cases. However, by testing the differences in relative yield of skin with subcutaneous fat tissue of leg, share of intermuscular fat tissue of shoulder, LSD and TRS, significance at the level of 5% was determined in fatteners with greater back fat thickness on withers. Observed differences relating to the effect of back fat thickness on share of skin with subcutaneous fat tissue in the carcass were significant and highly significant (*P<0,05 and **P<0,01). Positive correlation of medium strength was established (0,66859) between back fat thickness and content of skin with subcutaneous fat tissue. Between the content of intermuscular fat tissue and back fat thickness a strong positive correlation was established (0,76648).
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Yuehao, Luo, Zhang Deyuan, and Chen Huawei. "Research on Manufacturing Vivid Trans-Scale Shark Skin Surface and Drag-Reducing Effect Simulation." Advanced Science Letters 5, no. 1 (January 1, 2012): 49–55. http://dx.doi.org/10.1166/asl.2012.1965.
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Radovic, Cedomir, Marija Gogic, Nenad Katanic, Mirko Novakovic, Dragan Radojkovic, Nenad Terzic, and Radomir Savic. "The share of tissues in the pig round depending on the genotype, gender and season." Biotehnologija u stocarstvu 35, no. 4 (2019): 367–75. http://dx.doi.org/10.2298/bah1904367r.
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The study included 201 offspring (108 castrated males and 93 females) of Landrace (L), Large White (LW) and Pietrain (P) sires. The studied animals were of following genotype: Landrace (L; n = 48); two breed crosses with 50:50 share of parental breeds (LWxL, n=32; and PxL, n=23), two breed crosses with 75% of paternal breed [Lx(?LWxL), n=35] and [LWx(?LxWL) n=38] and three breed crosses [Px(?LWxL) n=25]. Animals included in this study were born during four seasons: winter (n=38), spring (n=65), summer (n=40) and autumn (n=58). Studies have shown that, at an average weight of warm carcass side of 81.20 kg, the highest average values for the weight of round (RW; 10.204 kg), the weight of intermuscular fatty tissue (RINT; 0.478 kg), bone tissue (RBT; 0.850 kg) and muscle tissue (RMT, 7.552 kg) in the round, were established in three-breed crosses of Px (LWxL) genotype compared to other genotypes. The least skin and subcutaneous fatty tissue (RST; 1.269 kg) was recorded in two breed crosses PxL. They had less skin and subcutaneous fatty tissue by 454 g and 467 grams, respectively, compared to two breed crosses (LWxL) and LWx (?LxLW). Research has shown that there is a genotype on a farm that gives more muscle tissue in the round by 1.521 kg [Px (?LWxL): LWx (?LWxL)] with the same weight of warm carcass side, which is a very large difference. With the same average weight of warm carcass side, female animals had higher average weight of the round and yield of muscle tissue compared to male castrated animals. The effect of genotype (P<0.001) on all investigated traits was recorded, also the effect of the season of birth on the skin and subcutaneous fat tissue and on the weight of intermuscular fat in the round was recorded. The effect of sex/gender was significant (P<0.01) on the weight of skin and subcutaneous fat and on the weight of the muscle tissues in the round but no significant effect on other tested properties (P> 0.05) was observed.
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Martin, Samuel, and Bharat Bhushan. "Fluid flow analysis of a shark-inspired microstructure." Journal of Fluid Mechanics 756 (September 1, 2014): 5–29. http://dx.doi.org/10.1017/jfm.2014.447.
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AbstractThe scales of fast-swimming sharks contain riblet structures with microgrooves, aligned in the direction of fluid flow, that result in water moving efficiently over the surface. In previous studies, these riblet structures have shown a drag reduction of up to 10 % when compared with a smooth, flat surface. These studies have suggested two prevalent drag-reduction mechanisms which involve the effect of vortices and turbulence fluctuations. To further explore relevant mechanisms and study the effect of riblet geometry and flow properties on drag, vortices and turbulence fluctuations, various shark-skin-inspired riblet structures were created using computational models in which velocity, viscosity, spacing, height and thickness parameters were independently modified. A relevant mechanism of drag reduction is discussed to relate riblet parameters and flow properties to drag change and vortex size. Modelling information will lead to a better understanding of riblets and allow for optimum drag-reducing designs for applications in marine, medical and industrial fields.