Dissertations / Theses on the topic 'Shadow protein'
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Premzl, Marko, and Premzl@anu edu au premzl@excite com Marko. "Prion Protein Gene and Its Shadow." The Australian National University. The John Curtin School of Medical Research, 2004. http://thesis.anu.edu.au./public/adt-ANU20050328.164529.
Full textSakthivelu, Vignesh. "Functional characterization of Shadoo, a PrP-like protein with neuroprotective activity." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-144326.
Full textGajic, Ciric Danica. "Biochemical and structural study of Shadoo protein and its interaction with PrP." Paris 7, 2014. http://www.theses.fr/2014PA077150.
Full textShadoo (Sho) protein belongs to prion protein family. From the histo-anatomical co-localization and sequence similarities, it is suspected that Sho and PrP may be functionally related. Down regulation of Sho expression during prion pathology in one hand, and direct interaction between Sho and PrP, revealed by two-hybrid assay, suggests a relation between Sho and prion replication. The objective of this PhD thesis was to explore involvement of Sho in conformational dynamics of PrP and its effect on conversion process involved in prion replication. Secondary structure characterization of Sho revealed that Sho is a disordered protein between 3. 5
Meneghini, Rafael Cedric Möller. "Ferramenta para maximização do lucro de laticínios pelo planejamento do mix ótimo de produtos lácteos e precificação dos componentes do leite cru." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-30042014-113554/.
Full textSmall and medium-sized dairies face great difficulties in production planning to maximize profit. In addition, the current way of pricing the raw milk in Brazil discourages producers to improve its quality because its volume values more than its solid components. The raw milk composition is very important for the dairies because it directly affects the yield and quality of dairy products. Optimization techniques, such as linear programming (LP), aid solve problems related to the decision of the product mix and perform economic analyzes of resources. For this reason, a model was developed in LP to maximizing total contribution margin (TCM = total sales revenues - total variable costs and expenses) and pricing the raw milk by determining the optimal mix of dairy products. The model was simulated in two daily scenarios of high (January) and low (July) availability of raw material comparing the optimal solutions with actual results from a dairy plant in Southeastern Brazil. Sensitivity analyzes of the nutritional components of two kinds of raw milk of different compositions (RM1 and RM50) were performed to determine their shadow-prices. Shadow-prices were observed for the kilogram of casein in January and July and for the liter of RM50 in July. The optimal TCM and the calculated prices of both types of raw milk were higher in January due the increased availability of raw materials. In both scenarios, the calculated prices of both types of raw milk were higher than those paid by the dairy plant and the actual daily earnings before interests, taxes, depreciation and amortization (EBITDA) were greater than the optimum ones. The wrapper was an active limiting resource in the production of Frescal Minas cheese in optimal mixes. The relationship between unit contribution margin (UCM = unit sales price - unit variable cost and expense) and required amount of raw material per unit of output and resource availability are crucial in defining the mix of dairy products and the dairy TCM. The proposed raw milk pricing model pays the producer by the quantity of its components. The dairies can maximize their EBITDA planning their product mixes with LP and remunerating their suppliers based on the quality of raw milk.
Blanco, Touriñán Noel. "New mechanisms of DELLA protein regulation and activity in Arabidopsis." Doctoral thesis, Universitat Politècnica de València, 2020. http://hdl.handle.net/10251/149477.
Full text[ES] Las proteínas DELLA son reguladores transcripcionales específicos de plantas que transmiten información ambiental a las redes transcripcionales que modulan el crecimiento y el desarrollo. La propuesta de que las DELLAs actúan como "hubs" en redes de señalización se justifica por dos razones: primero, controlan la actividad de un gran número de factores de transcripción (FTs) y otros reguladores transcripcionales mediante interacción física; y segundo, son degradadas por el proteosoma 26S en respuesta a la fitohormona giberelina (GA), cuyo metabolismo es muy sensible a los estímulos ambientales (p. ej. luz, temperatura, estrés salino). Sin embargo, al menos dos observaciones sugieren que la información relativa a estos mecanismos no es completa: (i) las temperaturas altas desestabilizan incluso a rga-¿17, una versión de DELLA insensible a GAs, lo que indica que la estabilidad de las DELLAs no depende sólo de cambios en los niveles de GAs; y (ii) cuando se encuentran en la cromatina, las DELLAs no solo se posicionan en los promotores, sino también a lo largo de las regiones codificantes, lo que sugiere que las DELLAs podrían regular la transcripción mediante interacciones con otras proteínas diferentes a FTs. En esta Tesis, proporcionamos evidencia sobre una nueva E3 ubicuitina ligasa que controla la estabilidad de las DELLAs de una manera independiente a las GAs, y cómo las DELLA regulan la expresión génica interaccionando directamente con la maquinaria de transcripción basal. En el primer capítulo, usando una combinación de aproximaciones genéticas, fisiológicas y moleculares, demostramos que las DELLAs son marcadas para su degradación proteolítica por la E3 ubicuitina ligasa CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1). Mostramos que COP1 interacciona al menos con las DELLAs GAI y RGA in vitro e in vivo, y que promueve su poliubicuitinación. Proponemos que COP1 representa una vía importante de degradación de DELLAs en respuesta a sombra y temperaturas altas. En el segundo capítulo, describimos la interacción entre las DELLAs y el complejo de elongación transcripcional Polymerase-Associated Factor 1 (Paf1c). Mostramos que, como en animales, Paf1c se requiere para la deposición a nivel genómico de la H2B monoubiquitinada (H2Bub), una marca necesaria para la progresión de la RNA polimerasa II (RNAPII), y que esta función depende en gran medida de la presencia de DELLAs. Asimismo, la reducción de la función de las DELLAs provoca defectos equivalentes a los de la pérdida de función de Paf1c en cuanto a la acumulación y distribución de la RNAPII en los genes diana de Paf1c. Proponemos que las DELLAs podrían por tanto regular la transcripción modulando el reclutamiento de Paf1c a la cromatina. Estos nuevos mecanismos inciden en la importancia de las DELLAs como nodos centrales en las redes de señalización al ambiente y podrían ser considerados como dianas biotecnológicas en aproximaciones futuras.
[CA] Les proteïnes DELLA són reguladors transcripcionals específics de les plantes conegudes per transmetre informació mediambiental a les xarxes transcripcionals per modular el creixement i desenvolupament. La visió actual de DELLAs com a "hubs" de senyalització es justifica per dues característiques: en primer lloc, controlen l'activitat d'un gran nombre de factors transcripcionals (FTs) i d'altres reguladors transcripcionals mitjançant la interacció física; i, en segon lloc, es degraden pel proteosoma 26S en resposta a la fitohormona giberel.lina (GA), el metabolisme de la qual és molt sensible als estímuls ambientals (per exemple, la llum, la temperatura, l'estrès salí). No obstant això, almenys dues observacions indiquen que aquest marc mecanicista encara és incomplet: (i) la temperatura càlida desestabilitza la DELLA rga-¿17, que és insensible a GAs, indicant que les DELLA no es desestabilitzen només per canvis en els nivells d'aquesta fitohormona; i (ii) quan es troben a la cromatina, les DELLA no només es localitzen en els promotors dels gens, sinó també a la regió que es transcriu, cosa que suggereix que poden regular la transcripció mitjançant interaccions amb proteïnes diferents de FTs. En aquesta tesi, proporcionem evidències que mostren com una ubiquitina E3 lligasa diferent controla l'estabilitat de les proteïnes DELLA de manera independent de GAs, i com les DELLA regulen l'expressió gènica interactuant directament amb la maquinària transcripcional basal. En el primer capítol, mitjançant una combinació d'enfocaments genètics, fisiològics i moleculars, demostrem que les DELLA s'envien a la degradació proteolítica mitjançant la ubiquitina E3 lligasa CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1). Mostrem que la COP1 interacciona amb els DELLA GAI i RGA in vitro i in vivo, i que afavoreix la seva poliubiquitinació. Proposem que COP1 representa la via principal per degradar les DELLA en resposta a l'ombra o a la temperatura càlida. Al segon capítol, es descriu la interacció entre les DELLA i el complex d'allargament de transcripció Polymerase Associated Factor 1 (Paf1c). Mostrem que Paf1c es requereix per a la deposició a tot el genoma de H2B monoubiquitinada (H2Bub), una marca necessària per a la progressió de l'ARN Polimerasa II (RNAPII), i que aquesta funció depèn en gran part de la presència de DELLA. De la mateixa manera, quan la funció Paf1c o DELLA està deteriorada, es produeix una alteració similar en l'acumulació i distribució de RNAPII als gens diana de Paf1c. Proposem que les DELLA realitzen aquesta acció modulant el reclutament de Paf1c a la cromatina. Aquests dos nous mecanismes posen de manifest la importància de les proteïnes DELLA com a node central de la xarxa de senyalització ambiental i haurien de ser considerats en qualsevol aplicació potencial de DELLA com a objectius biotecnològics.
La realización de esta Tesis Doctoral ha sido posible gracias a un contrato predoctoral para la formación de doctores (BES-2014-068868) y a la ayuda a la movilidad predoctoral para la realización de estancias breves (EEBB-I-16-11070) del Ministerio de Economía y Competitividad, y a una beca EMBO Short-Term (number 8047).
Blanco Touriñán, N. (2020). New mechanisms of DELLA protein regulation and activity in Arabidopsis [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/149477
TESIS
Sakthivelu, Vignesh [Verfasser], and Jörg [Akademischer Betreuer] Tatzelt. "Functional characterization of Shadoo, a PrP-like protein with neuroprotective activity / Vignesh Sakthivelu. Betreuer: Jörg Tatzelt." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1023661055/34.
Full textShao, Lin [Verfasser], and Jörg [Akademischer Betreuer] Nickelsen. "Characterization of the TPR protein family and a putative photosynthetic protein from Synechocystis PCC 6803 / Lin Shao. Betreuer: Jörg Nickelsen." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1049393295/34.
Full textQu, Xiaoguang. "NMR Study of Structure and Orientation of S4-S5 Linker Peptides from Shaw Related Potassium Ion Channels in Micelles and Binding of ZNF29R Protein to HIV RREIIBTR RNA." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_diss/33.
Full textGonçalves, Gislei Cristina. "Cultivo em campo de Coffea arabica L. cv. Obatã a pleno sol x sombreamento parcial: avaliações bioquímicas, fisiológicas e nutricionais." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11144/tde-14052007-160536/.
Full textPlants of Arabian coffee with 4,5 years of age, had been compared from August to December growing under full sun and under natural shade conditions. The plants presented significant differences in growth terms and physiological and biochemical's aspects. The nitrogen supply in the October month provided a significant increase on levels of amino acid totals and the activity of nitrate redutase. The leaves of plants growing under natural shade presented greater fresh weight than full sun. The total protein levels abruptly decreased from the month 10 in all analyzed plants, time in coincidence with the beginning of filling up the grains. The increase on levels of total amino acids also was followed by an increase in the days of rain, the precipitation and also the global radiation. Didn't have significant effect with relation of localization of leaves (upper part X inferior part) within analyzed aspects. The nitrogen supply in month 10 did not modify the concentration of chlorophyll measured by chlorophyll meter SPAD, and chlorophyll total extracted did not change significantly until month 11 except in the sunny plants leaves of upper part that had a bigger synthesis in month 9. In month 12 had an increase on the levels of chlorophyll in all the treatments. The levels of foliar N had had positive correlation with the readings of chlorophyll analyzed by the SPAD, until month 11. We had also in the period of analyzes, a significant increase on the concentration of carotenoids from month 8, evidencing its photo protective effect. During this time also we had an increase in the global radiation in the period around 50%. The leaves in conditions of natural shade had presented greater dry weight that of full sun. The total protein levels abruptly decreased from the month 11 in all plants, time coincident with the beginning of the production/filling up of the grains. The Month 10 also had an increase in starch levels (except in leaves of third inferior of the sunny plants), decreasing in function of the filling up of the grains. Also an increased synthesis of reducing sugars was observed at the beginning and a decrease during the beginning of the formation of the grains. With regard to the nutrients in analyzed leaves, the manganese had a behavior significantly different in relation to others, where in leaves at the full sun the concentration of the element was 6 to 8 times higher than shaded leaves.
AL-Rawi, Shadha [Verfasser], Joerg [Akademischer Betreuer] Fettke, Alisdair [Akademischer Betreuer] Fernie, Christophe [Gutachter] D’Hulst, and Oluwatoyin A. [Gutachter] Odeku. "Biochemical studies to determine the role of Early Starvation 1 (ESV1) protein and its homologue Like-Early Starvation 1 (LESV) during starch degradation / Shadha AL-Rawi ; Gutachter: Christophe D’Hulst, Oluwatoyin A. Odeku ; Joerg Fettke, Alisdair Fernie." Potsdam : Universität Potsdam, 2020. http://d-nb.info/1223536769/34.
Full textAL-Rawi, Shadha Abduljaleel [Verfasser], Joerg [Akademischer Betreuer] Fettke, Alisdair [Akademischer Betreuer] Fernie, Christophe [Gutachter] D’Hulst, and Oluwatoyin A. [Gutachter] Odeku. "Biochemical studies to determine the role of Early Starvation 1 (ESV1) protein and its homologue Like-Early Starvation 1 (LESV) during starch degradation / Shadha AL-Rawi ; Gutachter: Christophe D’Hulst, Oluwatoyin A. Odeku ; Joerg Fettke, Alisdair Fernie." Potsdam : Universität Potsdam, 2020. http://d-nb.info/1223536769/34.
Full textMandal, Sayan. "Applications of Persistent Homology and Cycles." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1591811236244813.
Full textBryan, Shannon Anne. "Assessment of new drugs for asthma : effects of IL-2 on inhaled allergen challenge responses, screening chemokine receptor antagonists in a flow cytometric assay for eosinophil shade change, monitoring exhaled breath proteins captured using filters." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406483.
Full textPremzl, Marko. "Prion Protein Gene and Its Shadow." Phd thesis, 2004. http://hdl.handle.net/1885/48000.
Full textWatts, Joel Christopher. "Characterization of Shadoo and DPPX: Two Proteins of Potential Relevance to Prion Biology." Thesis, 2008. http://hdl.handle.net/1807/11275.
Full textShaw-Allen, Patricia Lynn. "[Delta]¹⁵N distribution as a marker linking altered metabolism of protein resources to mercury exposure." 2002. http://purl.galileo.usg.edu/uga%5Fetd/shaw-allen%5Fpatricia%5Fl%5F200212%5Fphd.
Full textCorley, Susan M. "Potential RNA binding functions for Shadoo through identification and characterisation of an RGG box motif." Phd thesis, 2010. http://hdl.handle.net/1885/149638.
Full textPursglove, Sharon Elizabeth. "Biophysical analysis of Tec Kinase regulatory regions : implications for the control of Kinase activity / by Sharon Elizabeth Pursglove." Thesis, 2001. http://hdl.handle.net/2440/21676.
Full textLin, Siou-Yan, and 林秀彥. "The study of feeding habits and protein expression pattern of Xenograpsus testudinatus in shallow-water hydrothermal vents of Kueishan Island." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/34189564962506745694.
Full text國立中山大學
海洋生物研究所
100
Xenograpsus testudinatus is a dominant species in shallow hydrothermal vents off Kueishan Island, Taiwan. But we know little about crab populations in vent areas. In this study, stable isotope and one dimension protein expression profiles were studied to evaluate the differences of X. testudinatus from different habitats, i.e. white and yellow vents. Results indicated food sources between the two habitats were different in 2009, but similar in 2010. The ranges of δ15N value of X. testudinatus were broad which might result from abundant food in white vent. Furthermore, zooplankton might not be the major food source of X. testudinatus. Significant difference in protein expression profiles between habitats indicate that they adapt to different habitats in small scales with migration between habitats. And, crabs may have other habitats outside vent areas. After culture in laboratory for 12 hours, crab protein expression profiles were different from their original ones, indicating their acclimation to a new environment is relative fast.