Dissertations / Theses on the topic 'Shadow of prion protein gene'
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Premzl, Marko, and Premzl@anu edu au premzl@excite com Marko. "Prion Protein Gene and Its Shadow." The Australian National University. The John Curtin School of Medical Research, 2004. http://thesis.anu.edu.au./public/adt-ANU20050328.164529.
Full textMead, Simon Harvey. "Molecular genetic analysis of the prion protein gene locus in human prion disease." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417947.
Full textMoore, Richard C. "Gene targeting studies at the mouse prion protein locus." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/11184.
Full textSoldevila, Trepat Marta. "Genetic variation in humans and chimpanzees in the prion protein gene." Doctoral thesis, Universitat Pompeu Fabra, 2005. http://hdl.handle.net/10803/7189.
Full textIn the prion gene or PRNP, we have observed that the particular pattern of variation that we have found in this gene based on sequencing data in humans is due to positive selection, and that the method and the approach used to detect this selection critical. Ascertainment bias can be introduced by using SNP data and applying neutrality tests based on sequence diversity, therefore leading to anomalous conclusions being drawn. Moreover, we have seen that polymorphisms in codon 129 and 219 have big differences in frequency in different human populations and we have also seen that these positions are fixed in chimpanzees. The normal variation that we found in controls have been then compared with patients for the same region. The resequencing of PRNP in a very large sample of humans and chimpanzees has provided a great deal of information on this gene.
Thumdee, Patama. "The prenatal expression of mRNA and protein of the prion protein gene, PRNP, in sheep." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=983755728.
Full textUzun, Begum. "Surveillance Of Prion Protein (prp) Gene Polymorphisms In Turkish Native Sheep Breeds." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614353/index.pdf.
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eada). One novel allele (TL141HQ) was observed in Sakiz breed for the first time in this study.
Mallucci, Giovanna Rachele. "Prion protein gene knockout in the mouse using the Cre/1oxP system." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271231.
Full textMahal, Sukhvir Paul. "Isolation and characterisation of the promoter region of the human prion protein gene." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313746.
Full textPeralta, Oscar Alejandro. "Developmental Regulation of Prion Expression in Cattle and Mouse Embryonic Stem Cells." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28584.
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Ribeiro, Fernanda Trentini Lopes. "Polimorfismo do gene da proteína prion celular (prpc) e imunohistoquímica de tecido linfóide em ovinos = Polymorphism of cellular prion protein (PrPC) and immunohistochemistry of lymphoid tissue of sheep / Fernanda Trentini Lopes Ribeiro ; orientadora, Cristina Santos Sotomaior." reponame:Biblioteca Digital de Teses e Dissertações da PUC_PR, 2011. http://www.biblioteca.pucpr.br/tede/tde_busca/arquivo.php?codArquivo=2231.
Full textInclui bibliografias
Scrapie é uma doença neurodegenerativa, progressiva e fatal de ovinos e caprinos, pertencente ao grupo das Encefalopatias Espongiformes Transmissíveis (EETs), ou doenças priônicas. O acúmulo de uma isoforma normal (PrPSc) da proteína prion celular (PrPC)
Scrapie is a fatal, neurodegenerative disease that affects sheep and goats and belongs to the Transmissible Spongiform Encephalopathies (TSEs) or prion diseases. It is caused by the deposition of an abnormal isoform (PrPSc) of the host-encoded cellular pr
Smid, Jerusa. "Poliformismos do gene da proteína príon celular em pacientes com doença de Alzheimer." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-24052011-142607/.
Full textINTRODUCTION: The polymorphism in the prion protein gene (PRNP) may influence non prion neurological diseases. Some reports associate Alzheimers disease (AD) and the polymorphic codon 129 of the PRNP. This association has not been studied in Brazilian population. In this study we aimed to describe the association between the polymorphisms of codon 129 of the PRNP and AD. METHODS: One hundred AD patients were evaluated in the Cognitive and Behavioral Neurology Unit and Cognitive Disorders Reference Center of the Hospital das Clínicas of the University of São Paulo School of Medicine, matched for 111 controls, regarding to the PRNP polymorphism and cognitive measures. The PRNP polymorphisms were analyzed using denaturing high-performance liquid chromatography (DHPLC). Analyzes stratifying by apoE genotype was performed. RESULTS: The distribution of the codon 129 polymorphisms were: 45.5% M/M, 42.4% M/V and 12.2% V/V in AD patients; 39.6% M/M, 50.5% M/V and 9.9% V/V in the control group (p=0.503). The 117 codon analysis revealed silent allelic variant in 5% of AD patients and 3% of controls (p=0.780). The octarepeat deletion occurred in 5% of AD and 4% of controls (p=0.738). All AD patients and controls were N171N. One AD patient had a point mutation at codon 180 (V180I). Logistic regression failed to confirm any association between AD cognitive performance and the codon 129 of PRNP, as well as in the control group. There was no association between the codon 129 genotypes and genotypes and AD according to the apoE stratification. CONCLUSIONS: There were no differences in the frequency of the codon 129 polymorphism between AD. control group, according to the codon 129 polymorphisms. A point mutation at the codon 180 (V180I) was diagnosed in one patient
Yvinec, Romain. "Modélisation probabiliste en biologie moléculaire et cellulaire." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00749633.
Full textPremzl, Marko. "Prion Protein Gene and Its Shadow." Phd thesis, 2004. http://hdl.handle.net/1885/48000.
Full text"Genetic variation in humans and chimpanzees in the prion protein gene." Universitat Pompeu Fabra, 2005. http://www.tesisenxarxa.net/TDX-0202110-115800/.
Full textThumdee, Patama [Verfasser]. "The prenatal expression of mRNA and protein of the prion protein gene, PRNP, in sheep / von Patama Thumdee." 2007. http://d-nb.info/983755728/34.
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