Dissertations / Theses on the topic 'SG'
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Sanabria, José, Ennis Rosas, and Carlos Carpintero. "(α,β)-sg-compacidad y (α,β)-sg-conexidad en espacios topológicos." Pontificia Universidad Católica del Perú, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/96468.
Full textVácha, Václav. "Marketingová strategie firmy SG Snowboards." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-1906.
Full textGarcia, Kleber Ormande [UNESP]. "Infecção experimental de aves de postura (Gallus gallus domesticus) por cepas de Salmonella enterica sorovar Gallinarum (SG), SGNalr SGcobS e SGcobScbiA: Anatomopatologia, hemograma e perfil bioquímico sérico." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/95970.
Full textFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Este trabalho objetivou avaliar a anatomopatologia, o hemograma e o perfil bioquímico sérico de aves de postura inoculadas por Salmonella Gallinarum (SG) contendo os genes cobS e cbiA inoperantes (SGcobScbiA) que mostrou ser avirulenta em trabalhos anteriores, comparando-a com cepas virulentas SGNalr e SGcobS, para mostrar se SGcobScbiA pode ser componente de vacina contra cepas selvagens de SG e S.Enteritidis. 280 pintainhas foram distribuídas em 4 grupos (G); G1 (SGcobS), G2 (SGNalr), G3 (SGcobScbiA) e G4 (controle). Com exceção do G4, os grupos receberam 0,2 mL de suas respectivas cepas contendo aproximadamente 108 UFC/mL de inóculo, aos 5 dias de idade. A eutanásia foi realizada 24h antes (1DAI) e após a inoculação (1DPI), e 3 (3DPI), 5 (5DPI), 7 (7DPI), 10 (10DPI) e 15 (15DPI) dias após a administração do inóculo, sacrificando-se, em cada momento, dez aves de cada grupo. As aves foram sacrificadas, obtendo-se amostras de sangue utilizadas para os exames hematológicos e bioquímicos. Fragmentos de fígado, baço, timo, bursa de Fabricius, rins e coração foram destinados aos exames histológicos. As aves inoculadas com a cepa SGcobS tiveram comportamento semelhante às aves inoculadas por SGNalr, porém com algumas respostas diferentes nos exames hematológicos e bioquímicos. As aves inoculadas com a cepa SGcobScbiA tiveram comportamento semelhante ao grupo controle, entretanto foi verificado alterações brandas em alguns parâmetros, mostrando que estudos futuros devem ser feitos, verificando se as alterações constatadas não irão interferir no desempenho de aves vacinadas com a cepa SGcobScbiA.
The aim of the present study was to evaluate anatomopathology, hemogram and blood serum components of commercial layers experimentally inoculated with SGcobScbiA, which is a Salmonella Gallinarum (SG) strain it shows attenuation of the virulence in previous research and it was compared with high virulence SGNalr and SGcobS strains in order to show if SGcobScbiA has potential to be use as a vaccine against SG and S. Enteritidis wild strains. 280 commercial layers were divided into 4 groups (G); G1 (SGcobS), G2 (SGNalr), G3 (SGcobScbiA) and G4 (control group). With exception of G4, all the other groups received 0,2 mL of their respective strain containing about 108 CFU/mL of the inoculum with five days of age. Birds were sacrificed 24 hours before (1DBI) and 24 hours after the inoculation (1DAI), and three (3DAI), five (5DAI), seven (7DAI) ten (10DAI), and fifteen (15DAI) days after the administration of the inoculum, slaughtering ten birds at a time in each group. Birds were submitted to euthanasia and blood samples were collected in order to make the hematological and blood serum components test. Samples of liver, spleen, thymus, bursa of Fabricius, kidneys and heart were collected for the histological test. The birds inoculated with SGcobS strain had similar behavior when compared with that ones who received SGNalr strain, however some different responses in the hematological and blood serum components were found. On the other hand, the birds inoculated with SGcobScbiA strain had similar behavior when compared with the control group, however, lower alterations in some parameters were found. Further studies must be done to verify if these alterations will not interfere in the performance of the vaccinate birds with SGcobScbiA strain.
Garcia, Kleber Ormande. "Infecção experimental de aves de postura (Gallus gallus domesticus) por cepas de Salmonella enterica sorovar Gallinarum (SG), SGNalr SGcobS e SGcobScbiA: Anatomopatologia, hemograma e perfil bioquímico sérico /." Jaboticabal : [s.n.], 2010. http://hdl.handle.net/11449/95970.
Full textAbstract: The aim of the present study was to evaluate anatomopathology, hemogram and blood serum components of commercial layers experimentally inoculated with SGcobScbiA, which is a Salmonella Gallinarum (SG) strain it shows attenuation of the virulence in previous research and it was compared with high virulence SGNalr and SGcobS strains in order to show if SGcobScbiA has potential to be use as a vaccine against SG and S. Enteritidis wild strains. 280 commercial layers were divided into 4 groups (G); G1 (SGcobS), G2 (SGNalr), G3 (SGcobScbiA) and G4 (control group). With exception of G4, all the other groups received 0,2 mL of their respective strain containing about 108 CFU/mL of the inoculum with five days of age. Birds were sacrificed 24 hours before (1DBI) and 24 hours after the inoculation (1DAI), and three (3DAI), five (5DAI), seven (7DAI) ten (10DAI), and fifteen (15DAI) days after the administration of the inoculum, slaughtering ten birds at a time in each group. Birds were submitted to euthanasia and blood samples were collected in order to make the hematological and blood serum components test. Samples of liver, spleen, thymus, bursa of Fabricius, kidneys and heart were collected for the histological test. The birds inoculated with SGcobS strain had similar behavior when compared with that ones who received SGNalr strain, however some different responses in the hematological and blood serum components were found. On the other hand, the birds inoculated with SGcobScbiA strain had similar behavior when compared with the control group, however, lower alterations in some parameters were found. Further studies must be done to verify if these alterations will not interfere in the performance of the vaccinate birds with SGcobScbiA strain.
Orientador: Ângelo Berchieri Júnior
Coorientador: José Jurandir Fagliari
Banca: Antonio Carlos Alessi
Banca: Raimundo Souza Lopes
Mestre
Andrews, Graeme David. "SG fourier integral operators with closure under composition." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/11990.
Full textAlcántara, Pope Moisés, and Cruz Eileen Belinda Loayza. "Implementación de un Sistema de Gestión de Seguridad y Salud Ocupacional en Minería Subterránea basado en las Normas Peruanas en la Contrata Minera Madsur SRL." Bachelor's thesis, Universidad Continental, 2019. http://repositorio.continental.edu.pe/handle/continental/5755.
Full textDingli, Jennifer. "Modellazione CAD e studio di motorizzazione dell'aliante SG-38." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/4387/.
Full textBoehnel, K. [Verfasser]. "Die Plutoniumbestimmung in Kernbrennstoffen mit der Neutronenkoinzidenzmethode / K. Boehnel." Karlsruhe : KIT-Bibliothek, 2010. http://d-nb.info/1188431900/34.
Full textValdivia, Zegarra William. "Propuesta de implementación de un Sistema de Gestión de Seguridad y Salud Minera en el trabajo, para la Empresa M3 Ingeniería Perú S.A.C." Bachelor's thesis, Universidad Continental, 2018. http://repositorio.continental.edu.pe/handle/continental/5206.
Full textLeproux, Alexis. "Un discours de sagesse : étude exégétique de SG 7 - 8 /." Roma : Ed. Pontificio Istituto Biblico, 2007. http://www.loc.gov/catdir/toc/casalini06/07946397.pdf.
Full textParrent, Kim Louise. "Traveling Through the Iris: Re-producing Whiteness in Stargate SG-1." Thesis, University of Canterbury. School of Humanities, 2010. http://hdl.handle.net/10092/3913.
Full textŽemaitienė, Jolanta. "Preparatų Lyprot SG-9 ir Aviance įtaka paukscių augimui ir produkcijos kokybei." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2004. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2004~D_20040608_165303-49237.
Full textVieira, Otávio Augusto Ruiz Paccola [UNESP]. "Geologia da folha guapiara 1:50000 (SG-22-X-B-II-2)." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/150504.
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A Folha Topográfica de Guapiara 1: 50000 (SG-22-X-B-II-2) situa-se no extremo sul do estado de São Paulo e compreende na porção central da Província Mantiqueira a faixa centro-sul do Cinturão Ribeira. O arcabouço geológico local envolve rochas da sequência metavulcanossedimentar do Supergrupo Açunguí, de idade meso- a neoproterozoicas metamorfizadas e deformadas no Neoproterozoico, associadas a rochas granitoides gerados durante os episódios colisionais ligados ao Ciclo Brasiliano e à formação do Supercontinente Gondwana. Na região, oito unidades litoestratigráficas principais foram mapeadas: metassedimentos da Formação Água Clara e dos grupos Votuverava e Itaiacoca de idade meso- a neoproterozoica, corpos graníticos neoproterozoicos representantes do Granito Três Córregos, corpos graníticos neoproterozoicos a cambrianos do Granito Capão Bonito, rochas sedimentares do Grupo Itararé, intrusivas básicas associadas a Formação Serra Geral e sedimentos recentes Quaternários. O quadro estruturalmetamórfico é determinado dominantemente pelo arranjo tectônico final neoproterozóico, evidenciado nas rochas epimetamórficas por uma evolução estrutural do tipo polifásica. As estruturas primárias S0, devido aos intensos processos de transposição das foliações dúctil e deformação milonítica, apresentamse preservadas de forma escassa em algumas áreas, com predomínio somente do acamamento gradacional reliquiar S0, nas áreas menos deformadas, a um bandamento tectônico nas regiões da zona de cisalhamento. São registradas quatro fases deformacionais e três metamórficas principais: a fase Dn, de baixo a médio ângulo e direção preferencial NE/SW, subparalela ao bandamento composicional S0; a fase Dn+1, de baixo a médio ângulo e direção preferencial NW/SE; a fase Dn+2, de alto ângulo e direção preferencial NE/SW, sendo esta fase a mais penetrativa e a principal e a fase Dn+3, de alto ângulo e direção preferencial NW/SE. Os eventos metamórficos associados são caracterizados pelo metamorfismo M1, o ápice metamórfico, do tipo regional progressivo na fácies xisto-verde alto a anfibolito baixo; M2, do tipo de contato em condições de baixa pressão e baixa a média temperatura, com a formação de hornfels e skarns locais; M3 metamorfismo regional regressivo na fácies xisto-verde baixa.
The Topographic Sheet of Guapiara 1: 50000 (SG-22-X-B-II-2) is located in the southernmost part of the state of São Paulo and comprises the central portion of the Mantiqueira Province, the central-southern belt of the Ribeira Belt. The local geological framework involves rocks from the metavulcanosedimentary sequence of the Açunguí Supergroup, meso to neoproterozoic metamorphosed age and deformed in the neoproterozoic, associated with granitoid rocks generated during the collisional episodes related to the Brasilian Cycle and to the formation of the Gondwana Supercontinent. In the region, eight main lithostratigraphic units were mapped: metasediments of the Água Clara Formation and the Votuverava and Itaiacoca Groups of meso-neoproterozoic age, neoproterozoic granite bodies representing the Três Córregos Granite, granite neoproterozoic bodies of the Capão Bonito Granite, sedimentary rocks of Itararé Group, basic effusives rocks associated with the Serra Geral Formation and recent sediments of the Quaternary. The structuralmetamorphic framework is dominantly determined by the final neoproterozoic tectonic arrangement, evidenced in the epimetamorphic rocks by a structural evolution of the polyphase type. The primary structures S0, due to the intense processes of transposition of ductile foliations and milonite deformation, are sparsely preserved in some areas, with predominance only of the relic gradation bedding of S0, in less deformed areas, to a tectonic banding in the regions of Shear Zone. Four deformational phases and three main metamorphic phases are recorded: the Dn phase, low to medium angle and preferential direction NE / SW, which is subparallel to the compositional bandage S0; The Dn + 1 phase, from low to medium angle and preferential direction NW / SE; The phase Dn + 2, of high angle and preferential direction NE / SW, this being the most penetrative and the main phase and the Dn + 3 phase, of high angle and preferential direction NW / SE. The associated metamorphic events are characterized by the metamorphism M1, the metamorphic apex, of the regional progressive type in the high greenschist to low amphibolite facies; M2, contact type under low pressure conditions and low to medium temperature, with the formation of hornfels and local skarns; M3, regressive regional metamorphism in low greenschist facies.
Vieira, Otávio Augusto Ruiz Paccola. "Geologia da folha Guapiara 1:50000 (SG-22-X-B-II-2) /." Rio Claro, 2017. http://hdl.handle.net/11449/150504.
Full textOrientador: Antonio Misson Godoy
Banca: Washington Barbosa Leite Junior
Banca: Jefferson Cassu Manzano
Resumo: A Folha topográfica de Guapiara 1: 50000 (SG-22-X-B-II-2) situa-se no extremo sul do estado de São Paulo e compreende na porção central da Província Mantiqueira a faixa centro-sul do Cinturão Ribeira. O arcabouço geológico local envolve rochas da sequência metavulcanossedimentar do Supergrupo Açunguí, de idade meso- a neoproterozoicas metamorfizadas e deformadas no Neoproterozoico, associadas a rochas granitoides gerados durante os episódios colisionais ligados ao Ciclo Brasiliano e à formação do Supercontinente Gondwana. Na região, oito unidades litoestratigráficas principais foram mapeadas: metassedimentos da Formação Água Clara e dos grupos Votuverava e Itaiacoca de idade meso- a neoproterozoica, corpos graníticos neoproterozoicos representantes do Granito Três Córregos, corpos graníticos neoproterozoicos a cambrianos do Granito Capão Bonito, rochas sedimentares do Grupo Itararé, intrusivas básicas associadas a Formação Serra Geral e sedimentos recentes Quaternários. O quadro estruturalmetamórfico é determinado dominantemente pelo arranjo tectônico final neoproterozóico, evidenciado nas rochas epimetamórficas por uma evolução estrutural do tipo polifásica. As estruturas primárias S0, devido aos intensos processos de transposição das foliações dúctil e deformação milonítica, apresentamse preservadas de forma escassa em algumas áreas, com predomínio somente do acamamento gradacional reliquiar S0, nas áreas menos deformadas, a um bandamento tectônico nas re... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The Topographic Sheet of Guapiara 1: 50000 (SG-22-X-B-II-2) is located in the southernmost part of the state of São Paulo and comprises the central portion of the Mantiqueira Province, the central-southern belt of the Ribeira Belt. The local geological framework involves rocks from the metavulcanosedimentary sequence of the Açunguí Supergroup, meso to neoproterozoic metamorphosed age and deformed in the neoproterozoic, associated with granitoid rocks generated during the collisional episodes related to the Brasilian Cycle and to the formation of the Gondwana Supercontinent. In the region, eight main lithostratigraphic units were mapped: metasediments of the Água Clara Formation and the Votuverava and Itaiacoca Groups of meso-neoproterozoic age, neoproterozoic granite bodies representing the Três Córregos Granite, granite neoproterozoic bodies of the Capão Bonito Granite, sedimentary rocks of Itararé Group, basic effusives rocks associated with the Serra Geral Formation and recent sediments of the Quaternary. The structuralmetamorphic framework is dominantly determined by the final neoproterozoic tectonic arrangement, evidenced in the epimetamorphic rocks by a structural evolution of the polyphase type. The primary structures S0, due to the intense processes of transposition of ductile foliations and milonite deformation, are sparsely preserved in some areas, with predominance only of the relic gradation bedding of S0, in less deformed areas, to a tectonic banding in the regio... (Complete abstract click electronic access below)
Mestre
Chiccone, Christopher Louis. "Automated SG-DBR Tunable Laser Calibration Optimized for Optical Coherence Tomography Applications." DigitalCommons@CalPoly, 2011. https://digitalcommons.calpoly.edu/theses/519.
Full textKane, Abdoul. "Activity propagation in two-dimensional neuronal networks." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1133461090.
Full textZhang, Haomin. "Essays on customer base concentration, SG&A costs stickiness, and investment efficiency." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/84.
Full textSparks, Tim. "Integrated surface water-groundwater modelling : linking surface water and groundwater using DIVAST-SG." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54617/.
Full textGilbert, David Wilkey. "Point-Spread Function Assessment of SG-DBR Based Swept Source for OCT Imaging." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/733.
Full textBernacil, Michael A. "Microwave Signal Generation Using Self-Heterodyning of a Fast Wavelength Switching SG-DBR Laser." DigitalCommons@CalPoly, 2008. https://digitalcommons.calpoly.edu/theses/19.
Full textNavrátil, Stanislav. "Předpokládaná opatření v sítí VN pro naplnění závěrů NAP SG v oblasti OZE a elektromobility." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442471.
Full textBernacil, Michael A. Derickson Dennis. "Microwave signal generation using self-heterodyning of a fast wavelength switching SG-DBR laser : a thesis /." [San Luis Obispo, Calif. : California Polytechnic State University], 2008. http://digitalcommons.calpoly.edu/theses/19/.
Full textMajor professor: Dennis Derickson, Ph.D. "Presented to the faculty of California Polytechnic State University, San Luis Obispo." "In partial fulfillment of the requirements for the degree [of] Master of Science in Electrical Engineering." "May 2008." Includes bibliographical references (leaves 147-149). Also available on microfiche (3 sheets).
Rodrigues, Alves Lucas Bocchini. "Patogenicidade de Salmonella Gallinarum com deleção dos genes phoP e phoQ (SG∆phoPQ) em aves comerciais." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152283.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
RESUMO – Salmonella Gallinarum (SG) é um patógeno hospedeiro-específico que causa o tifo aviário, doença sistêmica severa que é considerada uma das principais preocupações da indústria avícola mundial. Quando infecta a ave, SG utiliza mecanismos de evasão para sobreviver e replicar no interior de macrófagos. Nesse contexto, os genes phoPQ codificam o sistema regulatório de dois componentes (PhoPQ) que regula genes de virulência responsáveis pela adaptação de Salmonella spp. a fatores antimicrobianos como baixo pH, peptídeos antimicrobianos e baixas concentrações de cátions bivalentes. No presente estudo, objetivou-se investigar a função desses genes para SG. Assim, uma estirpe de SG com genes phoPQ defectivos (SG ∆phoPQ) foi construída e sua patogenicidade avaliada em aves poedeiras de 20 dias de vida susceptíveis ao tifo aviário. SG ∆phoPQ não causou sinais clínicos nem mortalidade em aves desafiadas oralmente, sendo não-patogênica. Ademais, essa estirpe não foi recuperada de fígados e baços. Por outro lado, aves desafiadas subcutaneamente com a estirpe mutante tiveram alterações patológicas discretas a moderadas e baixas contagens bacterianas em tecidos de fígado e baço. A partir dos dados, observa-se que SG ∆phoPQ é atenuado para aves o que sugere que ambos os genes são importantes durante a infecção sistêmica em aves por SG.
ABSTRACT – Salmonella Gallinarum (SG) is a host-restrict pathogen that causes fowl typhoid, a severe systemic disease that is one of the major concerns to the poultry industry worldwide. When infecting the bird, SG makes use of evasion mechanisms to survive and to replicate within macrophages. In this context, phoPQ genes encode a two-component regulatory system (PhoPQ) that regulates virulence genes responsible for adaptation of Salmonella spp. to antimicrobial factors such as low pH, antimicrobial peptides and deprivation of bivalent cations. Herein, we aimed to investigate the role of the mentioned genes to SG. Thus, a phoPQ-depleted SG strain (SG ∆phoPQ) was constructed and its virulence assessed in twenty-day-old laying hens susceptible to fowl typhoid. SG ∆phoPQ did cause neither clinical signs nor mortality in birds orally challenged, being non-pathogenic. Furthermore, this strain was not recovered from livers or spleens. On the other hand, chickens challenged subcutaneously with the mutant strain had discreet to moderate pathological changes and also low bacterial counts in liver and spleen tissues. These findings show that SG ∆phoPQ is attenuated to susceptible chickens and suggest that both genes are important during chicken systemic infection by SG.
PICETTI, ROBERTO. "Le role fonctionnel des recepteurs dopaminergiques d2 et leur interaction avec la proteine sg alpha i2." Université Louis Pasteur (Strasbourg) (1971-2008), 1999. http://www.theses.fr/1999STR13043.
Full textAngevine, Christopher. "CHARACTERIZATION OF INDIVIDUAL CHARGED Au25(SG)18 CLUSTERS AND THEIR ENHANCEMENT OF SINGLE MOLECULE MASS SPECTROMETRY." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/613.
Full textCardoso, Marisa Alexandra da Palma. "A língua como ativo na internacionalização da economia portuguesa." Master's thesis, Instituto Superior de Economia e Gestão, 2014. http://hdl.handle.net/10400.5/7834.
Full textNa conjuntura atual, o sucesso dos países a nível internacional é uma condição fundamental para o seu crescimento económico. Nas dinâmicas impostas pela globalização, emergem novos protagonistas e novas parcerias estratégicas, onde a língua tem um papel crucial, pelo que, a crescente atenção dos Estados na implementação de medidas, permite explorar as oportunidades nas economias que partilham a mesma língua e estão próximas culturalmente. Uma maior coerência na promoção da presença internacional e a utilização dos recursos endógenos, é fonte de valor acrescentado que cria riqueza, aumenta a produtividade e contribui para alcançar o pleno-emprego. Assim, esta dissertação procura enquadrar a relevância da língua enquanto elemento chave da internacionalização, desenvolvendo igualmente um estudo de caso.
In the current context, a country's economic growth strongly depends on its success at an international level. Among the dynamics imposed by globalization, new protagonists and new strategic partnerships where the language spoken plays a critical role, emerges. Therefore, States have been giving growing attention to the implementation of measures that allow for the exploration of opportunities in the economies that share the same language and culture. A greater coherence in the promotion of international presence and the use of indigenous resources is the source of added value that creates wealth, increases productivity and contributes to reaching full-employment. This thesis assesses the relevance of the spoken language in the internationalization of an economy and studies the case of a specific Portuguese company.
Ramalho, Lucas Arruda [UNESP]. "Modelagem IEEE 1815 DNP3 em VHDL e análise de comunicação SG via IEEE 802.15.4 e IEEE 802.11." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/111111.
Full textO conceito Smart Grid (SG) estabelece que, em adição ao fluxo de energia, a concessionária tenha um fluxo de dados de duas vias em todos os setores da rede até os consumidores. Através da Tecnologia da Informação e Comunicação (TIC), torna-se possível o sensoriamento de toda a grade de energia, a solução de falhas mais ágil e eficiente, e a teleproteção e gerenciamento dos ativos das concessionárias. Para que isso seja garantido, requisitos como segurança, confiabilidade e baixa latência são essenciais. Considerando que existem diversas aplicações SG, adaptar um sistema de comunicação, entre os medidores inteligentes (Smart Meters), para cada tipo de ambiente se torna complexo. Além disso, o estudo de comunicação do fluxo SG se torna oneroso na montagem de cenários reais, devido ao alto custo na aquisição de Smart Meters. A fim de possibilitar estudos simulados da comunicação SG de baixo custo, neste trabalho foi realizada a modelagem do protocolo IEEE 1815 DNP3, validou seu funcionamento através de modelagem das integrações IEEE 1815/ 802.15.4 e IEEE 1815/ 802.11b. A validação e análise foram realizadas pela modelagem e simulação de ambos os protocolos, em Very High Speed Integrated Circuit (VHSIC) Hardware Description Language (HDL), e efetuando medições de atraso na troca de mensagens DNP3 enviadas através dos protocolos sem fio integrados. Os requisitos de latência de teleproteção, em seu contexto geral, apontam a interface IEEE 802.15.4 como inadequada para esta aplicação por apresentar alta latência na presença de cenários de disputa de acesso, baixa vazão de dados e baixa resiliência de segurança implementada. Situação que não ocorre para a interface IEEE 802.11, que se torna factível pois apresenta latência, vazão de dados e robustez de segurança compatíveis com tal aplicação crítica
The Smart Grid (SG) concept provides that, in addition to the power flow, the utilities has a two-way data flow in all sectors of the grid to consumers. Through Information and Communication Technology (ICT), it becomes possible the sensing of entire power grid, the more efficient and faster solution failures, and the teleprotection and management of the assets of utilities. To ensure this, requirements such as security, reliability and low latency are essential. Considering that there are several applications SG, to adapt a communication system between Smart Meters for each type of environment becomes complex. Moreover, the communication study of data flow SG becomes expensive in assembling real scenarios, due to the high cost of acquisition of Smart Meters. To enable SG communication studies simulated in low cost, in this work was constituted the modeling of IEEE 1815 DNP3 protocol, validated its operation through modeling of IEEE 1815 / 802.15.4 and IEEE 1815 / 802.11b integrations. The validation and analysis were performed by modeling and simulation of both protocols in Very High Speed Integrated Circuit (VHSIC) Hardware Description Language (HDL), and performing measurements of delay in the exchange of DNP3 messages sent via integrated wireless protocols. The teleprotection latency requirements in its general context, indicate the IEEE 802.15.4 interface as inadequate for this application due to high latency scenarios in the presence of contention access, low data throughput and low resilience of improved security. Situation that does not occur for the IEEE 802.11 interface, which becomes feasible because it presents latency, data throughput and robustness safety critical application compatible with that SG
Kersten, Thomas. "Untersuchungen zum Penicillin-induzierten Tod bei Staphylococcus aureus Stamm SG 511 Berlin unter besonderer Berücksichtigung hoher Antibiotikadosen /." [S.l.] : [s.n.], 1999. http://www.gbv.de/dms/bs/toc/308904796.pdf.
Full textRamalho, Lucas Arruda. "Modelagem IEEE 1815 DNP3 em VHDL e análise de comunicação SG via IEEE 802.15.4 e IEEE 802.11 /." Ilha Solteira, 2014. http://hdl.handle.net/11449/111111.
Full textCo-orientador: Valtemir Emerêncio do Nascimento
Banca: Alexandre Cesar Rodrigues da Silva
Banca: Leopoldo Rideki Yoshioka
Resumo: O conceito Smart Grid (SG) estabelece que, em adição ao fluxo de energia, a concessionária tenha um fluxo de dados de duas vias em todos os setores da rede até os consumidores. Através da Tecnologia da Informação e Comunicação (TIC), torna-se possível o sensoriamento de toda a grade de energia, a solução de falhas mais ágil e eficiente, e a teleproteção e gerenciamento dos ativos das concessionárias. Para que isso seja garantido, requisitos como segurança, confiabilidade e baixa latência são essenciais. Considerando que existem diversas aplicações SG, adaptar um sistema de comunicação, entre os medidores inteligentes (Smart Meters), para cada tipo de ambiente se torna complexo. Além disso, o estudo de comunicação do fluxo SG se torna oneroso na montagem de cenários reais, devido ao alto custo na aquisição de Smart Meters. A fim de possibilitar estudos simulados da comunicação SG de baixo custo, neste trabalho foi realizada a modelagem do protocolo IEEE 1815 DNP3, validou seu funcionamento através de modelagem das integrações IEEE 1815/ 802.15.4 e IEEE 1815/ 802.11b. A validação e análise foram realizadas pela modelagem e simulação de ambos os protocolos, em Very High Speed Integrated Circuit (VHSIC) Hardware Description Language (HDL), e efetuando medições de atraso na troca de mensagens DNP3 enviadas através dos protocolos sem fio integrados. Os requisitos de latência de teleproteção, em seu contexto geral, apontam a interface IEEE 802.15.4 como inadequada para esta aplicação por apresentar alta latência na presença de cenários de disputa de acesso, baixa vazão de dados e baixa resiliência de segurança implementada. Situação que não ocorre para a interface IEEE 802.11, que se torna factível pois apresenta latência, vazão de dados e robustez de segurança compatíveis com tal aplicação crítica
Abstract: The Smart Grid (SG) concept provides that, in addition to the power flow, the utilities has a two-way data flow in all sectors of the grid to consumers. Through Information and Communication Technology (ICT), it becomes possible the sensing of entire power grid, the more efficient and faster solution failures, and the teleprotection and management of the assets of utilities. To ensure this, requirements such as security, reliability and low latency are essential. Considering that there are several applications SG, to adapt a communication system between Smart Meters for each type of environment becomes complex. Moreover, the communication study of data flow SG becomes expensive in assembling real scenarios, due to the high cost of acquisition of Smart Meters. To enable SG communication studies simulated in low cost, in this work was constituted the modeling of IEEE 1815 DNP3 protocol, validated its operation through modeling of IEEE 1815 / 802.15.4 and IEEE 1815 / 802.11b integrations. The validation and analysis were performed by modeling and simulation of both protocols in Very High Speed Integrated Circuit (VHSIC) Hardware Description Language (HDL), and performing measurements of delay in the exchange of DNP3 messages sent via integrated wireless protocols. The teleprotection latency requirements in its general context, indicate the IEEE 802.15.4 interface as inadequate for this application due to high latency scenarios in the presence of contention access, low data throughput and low resilience of improved security. Situation that does not occur for the IEEE 802.11 interface, which becomes feasible because it presents latency, data throughput and robustness safety critical application compatible with that SG
Mestre
Nguyen, Tien Dung. "Caractérisation in vitro du coronavirus de la gastroentérite transmissible (GET) et immunogénicité d'un mutant atténué (188-SG)." Tours, 1986. http://www.theses.fr/1986TOUR3802.
Full textWang, Die. "Millimeter and sub-millimeter satellite observations for ice cloud characterization : towards the ice cloud imager onboard MetOp-SG." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066366/document.
Full textThe meteorological observations from satellites in the microwave domain are currently limited to 190 GHz. The next generation of European operational Meteorological Satellite (EUMETSAT Polar System-Second Generation-EPS-SG) will carry an instrument, the Ice Cloud Imager (ICI), with frequencies up to 664 GHz, to provide unprecedented measurements in the sub-millimeter spectral range, aiming to improve the characterization of ice clouds over the globe. To prepare this upcoming satellite-borne sub-millimeter imager, during this thesis, scientific efforts have been made on four complementary aspects. Realistic radiative transfer simulations have been performed from 19 to 700 GHz, for real meteorological scenes, covering a large variability of clouds in Europe. The goal was two fold, first to better understand the sensitivity of the microwave to sub-millimeter waves to the cloud frozen phases, and second, to create a robust training database for a statistical cloud parameter retrieval. The Atmospheric Radiative Transfer Simulator (ARTS) is coupled with atmospheric profiles from the Weather Research and Forecasting (WRF) model, for twelve diverse European mid-latitude scenes. The single scattering properties of the hydrometeors (cloud ice, snow, graupel, rain, and cloud water) are carefully selected, especially for the frozen phases, and compatibility with the micro- physics in WRF is tested: the Discrete-Dipole Approximation (DDA) is adopted for snow particles. The resulting simulations have been systematically compared with coincident satellite observations from imagers and sounders up to 200 GHz. The agreement between simulations and observations shows the good quality of the simulated training database, at least up to 200 GHz
Yamato, Arlindo Akio. "Mapeamento Geológico de parte da Folha Bocaiúva do Sul (SG.22-X-D-I-2), escala 1:50.000." Universidade de São Paulo, 1999. http://www.teses.usp.br/teses/disponiveis/44/44134/tde-10082015-091556/.
Full textThe presente research was undertaken in the \"Morro do Setuva\" region and neighborhoods, countryside of Bocaiúva do Sul - Paraná, emphasizing geological mapping. In this ares outcrops the Atuba Complex and the Setuva, Capiru and Votuverava formations. The area was mapped in 1:50.000 scale. Eleven associations were mapped and three of them are related to Atuba Complex Domain: bended biotite-hornblende gneisses association (Pca3). The Capiru Formation Domain is represented by five lithological associations: silt-sand meta-rhythmites (Mc1), massive dolomitic meta-limestone (Mc2), fine-coarse quartzites (Mc4) and red phyllite (Mc5). These associations suggested marine regressive sequence to the sedimentation in the shallow carbonate platform. The Setuva Formation Domain corresponds to the following association: sericite schists (Ms1), fine-coarse quartzite and milonitics dolomitic meta-limestones (Ms3). Capiru and Setuva sedimentation basin was originated by an extensional event that produced an initial rift, which reached passive continental margin condition with a stable platform. In the Votuverava Formation Domain occurs meta-pelites (Mv1) and meta-basites (Mv2), Mv1 and Mv2 assigned different tectonic-sedimentary cycles from the ones that were deposited in Capiru and Setuva formations; the Lancinha Shear Zone is the tectonic limit between this domain and the others. The Atuba Complex is the local basemed of Capiru and Setuva formations and with them the complex has contacts through thrust shear zones with WNW-ESE transport. This event was responsible for a wide deformation of Setuva Formation and it had originated tectonofacies. A transpressive event, with major shear zones and associated folding, was recognized, the \"Antiforma do Setuva\" was rhe most important fold register. The metamorphism affected the Votuverava, Capiru and Setuva formations is green schist, chlorite zone. In the Atuba Complex was detected a development under high, medium and low polymetamorphism conditions.
Rocha, Joaquim Guilherme Simões de Jesus. "Desempenho do perfil SG 6042 modificado com flape morphing do tipo rotating rib e com o flape simples." Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/2021.
Full textThis master’s dissertation describes all the work carried out to numerically compare the aerodynamic performance of a regular flapped airfoil to a morphing flapped airfoil of the Rotating Rib style. Based on works previously done, the main purpose of this thesis is to validate experimental results retrieved in wind tunnel. Computational Assisted Design tools (CAD), to model the geometry of the wings’ profiles based on the ones already built, Computational Fluid Dynamics tools (CFD), through numerical calculation, and postprocessing tools, for data analyses, were used. To better define which model to use a comparison between the many available models in the tools with experimental data previously validated and revalidated in other studies. The turbulence model used was the k-ε Realizable with Standard Wall Functions, as it revealed itself as the closest to the experimental data. So a two-dimensional analysis was made, with a steady-state flow and a pressure-based solver with an absolute velocity formulation. The mesh created is a type C with an O type central zone of high resolution for a better definition of the boundary layer. The results show significant improvements concerning the morphing wing, regarding the lift and drag coefficients, which may lead to the improvement of the aircraft performance.
Creutzfeldt, Noah Angelo Benjamin. "The effect of water storages on temporal gravity measurements and the benefits for hydrology." Phd thesis, Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4857/.
Full textZeitabhängigen Gravimetermessungen, die in der Geodäsie und der Geophysik eingesetzt werden, um Variationen des Erdschwerefelds zu messen, werden durch lokale Wasserspeicheränderungen beeinflusst und verursachen – aus dieser Perspektive – ein hydrologisches Störsignal in den Gravimetermessungen. Gleichzeitig bietet der Teil des Gravimetersignals, der durch Wasserspeicheränderungen hervorgerufen wird, das Potential wichtige Informationen über hydrologische Speicher zu gewinnen, da zwar Wasserspeicher eine grundlegende Zustandsgröße hydrologischer Systeme darstellt, jedoch ihre Quantifizierung mit einem hohen Maß an Unsicherheiten auf der Feldskala behaftet ist. Diese Studie untersucht die Beziehung zwischen zeitabhängigen Gravimetermessungen und Wasserspeicheränderungen, um die Gravimetermessungen von dem hydrologischen Störsignal zu bereinigen und um den Nutzen der Gravimetermessungen für die Hydrologie zu erkunden. Dies geschieht am Beispiel des Supraleitgravimeters (SG) des Geodätischen Observatoriums Wettzell in Deutschland. Ein 4D Vorwärtsmodel mit einer räumlich genesteten Diskretisierungsdomäne wurde entwickelt, um die lokalen hydrologischen Masseneffekte auf Gravimetermessungen zu simulieren. Des Weiteren wurde ein intensives Messsystem am Geodätischen Observatorium Wettzell installiert, um die Wasserspeicheränderungen in allen relevanten Speicherkomponenten, also im dem Grundwasser, in der ungesättigten Zone und im Schneespeicher zu messen. Das Monitoringsystem beinhaltete auch einen wägbaren, monolithischen Lysimeter mit Matrixpotentialübertragung, der es uns ermöglichte, zum ersten Mal einen Lysimeter direkt mit einem Gravimeter zu vergleichen. Die Lysimetermessungen wurden in Kombination mit komplementären hydrologischen Beobachtungen und einem 1D-Modell verwendet, um die Wasserspeicheränderungen auf der Feldskala zu bestimmen. Die Gesamtwasserspeicheränderungen wurden bestimmt, Unsicherheiten abgeschätzt und der hydrologische Masseneffekt auf Gravimetermessungen berechnet. Schlussendlich wurde ein einfaches, konzeptionelles, hydrologisches Modell mittels der Zeitreihen von dem SG, Bodenfeuchte- und Grundwassermessungen kalibriert und evaluiert. Das Modell wurde durch einen “Split-Sample-Test” evaluiert und basierend auf unabhängig bestimmten Wasserspeicheränderungen bestimmt auf Grundlage der Lysimetermessungen validiert. Die Simulation des hydrologischen Masseneffektes auf Gravimetermessungen zeigte, dass Wasserspeicheränderungen von einem Meter Höhe entlang der Topographie, einen Erdschwereeffekt von 52 µGal hervorriefen, während in der Geodäsie im Allgemeinen die gleiche Wassermassenvariation in flachem Terrain eine Erdschwereeffekt von nur 42 µGal (Bouguer-Platte) hervorruft. Der Einflussradius der lokalen Wasserspeicheränderungen kann auf 1000 m begrenzt werden, und 50 % bis 80 % des lokalen hydrologischen Erdschweresignals wird in einem Radius von 50 m um den Gravimeter generiert. Wasserspeichervariationen in der Schneedecke, im Oberboden, dem ungesättigten Saprolith und im gelüfteten Aquifer, sind allesamt wichtige Größen der lokalen Wasserbilanz. Mit der Ausnahme von Schnee beeinflussen alle Speicheränderungen die Gravimetermessungen in derselben Größenordnung und sind daher für die Gravimetermessungen von Bedeutung. Ein Vergleich des lokalen hydrologischen Gravitationseffektes mit den SG Residuen zeigte sowohl ereignisbezogene als auch saisonalen Übereinstimmungen. Weiterhin zeigten die Ergebnisse jedoch auch die Grenzen bei der Bestimmung der gesamten lokalen Wasserspeichervariationen mithilfe hydrologischer Punktmessungen auf. Die Ergebnisse des Lysimeter-basierten Ansatzes zeigten, dass SG Residuen mehr noch, als bisher aufgezeigt, durch lokale Wasserspeicheränderungen hervorgerufen werden. Ein Vergleich der Resultate mit anderen Methoden, die in der Vergangenheit zur Korrektur zeitabhängiger Erdschwerebeobachtungen durch Bestimmung des lokalen hydrologischen Masseneffekte verwendet wurden, zeigte, dass die unabhängige Berechnung von Wasserspeicheränderungen durch Lysimetermessungen erheblich verbessert werden kann und dass diese somit eine verbesserte Methode zur Bestimmung des lokalen hydrologischen Erdschwereeffekts darstellt. Die Installation eines Lysimeters ist somit im Zusammenhang mit einer Reduzierung des hydrologischen Störsignals und an Standorten, wo zeitabhängige Erdschwerebeobachtungen für geophysikalische Studien, die über die lokale Hydrologie hinausgehen verwendet werden, zu empfehlen. Aus hydrologischer Sicht zeigte diese Studie, dass die Verwendung von zeitabhängigen Gravimetermessungen als Kalibrierungsdaten die Modellergebnisse im Vergleich zu hydrologischen Punktmessungen verbesserten. Auf Grund ihrer Fähigkeit, über verschiedene Speicherkomponenten und ein größeres Gebiet zu integrieren, bieten Gravimeter verallgemeinerte Informationen über die Gesamtwasserspeicherveränderungen auf der Feldskala. Diese integrative Eigenschaft macht es notwendig, Erdschweredaten in hydrologischen Studien mit großer Vorsicht zu interpretieren. Dennoch können Gravimeter der Hydrologie als neuartiges Messinstrument dienen und die Nutzung von Gravimetern, die speziell für die Beantwortung noch offener Forschungsfragen der Hydrologie entwickelt wurden wird hier empfohlen.
Stravinskas, Robertas. "Visaverčių kombinuotųjų pašarų kiaulėms gamyba, kokybės kontrolė ir panaudojimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2007. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20070419_111639-58104.
Full textШвец, Сергей Викторович, and В. Г. Воропай. "Элементы сетецентрического управления обслуживанием энергосистемы." Thesis, НТУ "ХПИ", 2016. http://repository.kpi.kharkov.ua/handle/KhPI-Press/25939.
Full textPomeranz, Marcelo Christian. "The Role of the AtTZF1 Tandem CCCH Zinc Finger Gene in Plant Growth, Development, and Stress Response." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299525118.
Full textBogamuwa, Srimathi Priyadarshani. "FUNCTIONAL CHARACTERIZATION OF THREE SEED-SPECIFIC TANDEM CCCH ZINC FINGER PROTEINS IN Arabidopsis thaliana." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417514831.
Full textEscalante, Atencio Betzabeth Lissetti. "Nivel de conocimiento sobre la prevención de hipoacusia inducida por ruido en los usuarios que acuden a la Clínica ocupacional SG NATCLAR - 2009." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2010. https://hdl.handle.net/20.500.12672/9946.
Full textDetermina el nivel de conocimiento de los usuarios que acuden a la Clínica Ocupacional SG Natclar sobre las medidas preventivas de la hipoacusia inducida por ruido 2009. El estudio es de nivel cuantitativo, método descriptivo, de corte transversal. La población estuvo constituida por todos los usuarios que acuden a la Clínica Ocupacional SG Natclar Noviembre – 2009. La técnica fue la encuesta y el instrumento un cuestionario considerando el consentimiento informado. Del 100% (30), 63% (19) presentan conocimiento medio, 20% (6) bajo y 17 % (5) alto. En relación a la dimensión Nivel de Conocimiento sobre la enfermedad, 60% (18) presentan un nivel de conocimiento medio, 37 % (11) alto y 3 % (1) bajo; sobre los efectos del ruido, 43% (13) presentan un nivel de conocimiento alto, 37 % (11) bajo y 20 % (6) medio; acerca de la protección auditiva 15% (50) presentan un nivel de conocimiento medio, 37 % (11) bajo y 13 % (4) alto. La conclusión es que la mayoría de los usuarios tiene un nivel de conocimiento medio sobre las medidas preventivas de la Hipoacusia Inducida por ruido ya que conocen que el ruido constituye un riesgo para su salud y desconocen los factores que disminuyen la audición, que son los protectores auditivos, el tiempo de utilización de los protectores auditivos , el tiempo máximo permisible de exposición a ruido ,el periodo de la realización de la audiometría y las medidas preventivas que se aplican en su área de trabajo, traduciéndose en un alto costo económico, y alterando su calidad de vida.
Trabajo académico
HADJ, SAHRAOUI NADIA. "Processus involutifs affectant les cellules de purkinje au cours du vieillissement chez deux mutants neurologiques : les souris heterozygotes staggerer (+/sg) et reeler (+/rl)." Paris 6, 1996. http://www.theses.fr/1996PA066779.
Full textTalkington, Desmond Charles. "Characterization and Modeling of an O-Band 1310 nm Sampled-Grating Distributed Bragg Reflector (SG-DBR) Laser for Optical Coherence Tomography (OCT) Applications." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/983.
Full textJurjiu, A., R. Dockhorn, O. Mironova, and J. U. Sommer. "Two universality classes for random hyperbranched polymers." Royal Society of Chemistry, 2014. https://tud.qucosa.de/id/qucosa%3A36397.
Full textHellström, Karlsson Rebecca, and Tobias Peterson. "Extracting Cardiac and Respiratory Self-Gating Signals from Magnetic Resonance Imaging Data." Thesis, KTH, Skolan för teknik och hälsa (STH), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-171570.
Full textRörelseartefakter på grund av hjärt- och respirationsrörelser är idag vardagliga utmaningar inom magnetresonanstomografi (MR) av hjärtat, och många olika metoder används för att eliminera rörelseartefakterna. Patienterna behöver dessutom hålla andan under delar av dataupptagningen, vilket är fysiskt ansträngande – speciellt när det sker upprepade gånger. Self-Gating (SG) är en metod som extraherar information hjärt- och respirationsrytm från MR-datan i form av signaler, kallade SG signaler, och använder dem för att dela in datan i de specifika hjärt- respektive respirationsfaser som var när datan upptogs. Denna metod både undviker rörelseartefakter och tillåter fri andning under dataupptagningen. Målet med det här projektet var att hitta en metod för att extrahera SG signaler för hjärt- och respirationsrytm från MR-data. Datan samlades in med en golden angle radial-upptagning för 3- dimensionella (3D) scanningar. Extraheringen av den råa signalen testades på både rå k-space data och på bildserier av 3D-bilder med hög tidsupplösning, där bilderna var rekonstruerade med en sliding window rekonstruktion. Därefter applicerades filter för att isolera hjärt- och respirationsinformationen, för att få separata SG signaler med endast hjärt- respektive respirationsrytmer. Till slut genererades triggerpunkter för att markera början av hjärt- respektive respirationscyklerna. Dessa jämfördes med triggerpunkter uppmätta med EKG och andningskudde i magnetkameran. Slutsatsen för projektet var att SG signalerna som baserades på k-space data var funktionell för de scanningar som testades och det mest effektiva alternativet, men SG signalerna som baserades på bilder kan visa sig fungera efter mer studier.
LEDRU, PIERRE-CLAUDE. "Depistage de l'infection urinaire par bandelette reactive en geriatrie : evaluation de multistix 8-sg et de son lecteur specifique dans un centre de soins pour personnes agees." Lille 2, 1990. http://www.theses.fr/1990LIL2M320.
Full textWild, River Su, and swildriv@cres20 anu edu au. "The environmental implications of the local-state antinomy in Australia." The Australian National University. Centre for Resource and Environmental Studies, 2002. http://thesis.anu.edu.au./public/adt-ANU20040922.142838.
Full textMudzanani, Nndanduleni Bethuel. "Die verhouding tussen literêre teorie en kritiek in die Afrikaanse literêre sisteem binne die sg. "nuwe paradigma" aan die hand van gekose figure Marianne de Jong, Joan Hambidge en Gerrit Olivier." Thesis, Rhodes University, 1990. http://hdl.handle.net/10962/d1002174.
Full textCoimbatore, Raamanujan Sudarshan. "Fault Modeling and Analysis of LP Mode FinFET SRAM Arrays." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378195924.
Full textVycpálek, Martin. "Strategie implementace inteligentních systémů měření do české elektroenergetiky." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-17103.
Full textFernandes, Margareth. ""Expressão de Zap-70 e CD38 em leucemia linfocítica crônica (LLC) e sua correlação com prognóstico"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5136/tde-30052006-160411/.
Full textActually, chronic lymphocytic leukemia (CLL) can be divided in two subsets: one with somatically mutated immunoglobulin heavy-chain variable-region genes (MIgVH) and other with unmutated sequences. (UMIgVH). Some studies have shown that CD38 expression in CLL cells are correlated with IgVH mutational status. However, the value of CD38 as surrogate IgVH mutational status is controversial. Recent studies, have found that Zap-70 protein tyrosine kinase expression is strongly associated with the mutational status IgVH. The aim of this study was to evaluate the Zap-70 and CD38 expression, for flow cytometry, in CD19+ LLC cells and correlate with the Binets staging system, treatment-free survival (TFS) and a overall survival (OS). Zap-70 and CD38 was evaluated, in 144 CLL patients that was classified in A, B and C Binets staging system: 59 (41%) in stage A, 38 (26%) in B and 47 (33%) in C. We observed low Zap-70 and CD38 expression in stage A patients than in stage B and C cases. When we analyzed the TFS in stage A patients Zap-70+ and CD38+ patients showed shorter TFS than Zap-70- and CD38-. Then we observed that the OS of Zap-70+ and CD38+ patients was, also, shorter than Zap-70- and CD38- cases. However, statistical differences was not found when Zap-70 and CD38 expression was correlated with stage A, B or C Binets staging system. To understand the associated Zap-70 and CD38 expression, we divided the CLL patients in two subgroups (Zap-70-/CD38 - and Zap-70+ or CD38+). We observed that CD38+ or Zap-70+ was associated Binets staging system, once most of stage B (74%) and C (66%) patients are Zap-70+ or CD38+. However, stage A patients, Zap-70+ or CD38+, showed shorter OS than Zap-70-/CD38-. These differences were not observed in stage B and C patients. Shorter TFS was also observed in the Zap-70+ or CD38+ stage A patients. These results suggest that combined analysis of Zap-70 and CD38 can be used to evaluate stage A patients to observe the clinical evolution of the disease. Nevertheless, other studies must be carried to confirm the clinical use of these markers.
Kurzmeyer, Roman. "Viereck und Kosmos : Künstler, Lebensreformer, Okkultisten, Spiritisten in Amden 1901 - 1912; Max Nopper, Josua Klein, Fidus, Otto Meyer-Amden; [erscheint zur Ausstellung "Viereck und Kosmos - Künstler, Lebensreformer, Okkultisten, Spiritisten in Amden 1901 - 1912" Amden SG und Kunsthaus Glarus 27. Juni bis 29. August 1999] /." Wien [u.a.] : Springer-Verl, 1999. http://swbplus.bsz-bw.de/bsz078891043cov.htm.
Full text