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Journal articles on the topic 'SEVR'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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1

Tagawa, Kaname, Youngju Choi, Song-Gyu Ra, Toru Yoshikawa, Hiroshi Kumagai, and Seiji Maeda. "Resistance training-induced decrease in central arterial compliance is associated with decreased subendocardial viability ratio in healthy young men." Applied Physiology, Nutrition, and Metabolism 43, no. 5 (May 2018): 510–16. http://dx.doi.org/10.1139/apnm-2017-0449.

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High-intensity resistance training decreases central arterial compliance (CAC). Subendocardial viability ratio (SEVR) is a useful tool that reflects the balance between coronary perfusion and left ventricular afterload. Animal studies have demonstrated that decreased CAC is associated with SEVR deterioration. Therefore, resistance training-induced decrease in CAC may be associated with changes in SEVR. The objective of the present study was to investigate the association between SEVR and CAC using both cross-sectional and longitudinal (i.e., resistance training) study designs. To achieve this, we first conducted a cross-sectional study to investigate the association between SEVR and CAC in 89 young men. Thereafter, a longitudinal study was performed to examine the effects of resistance training on SEVR and CAC in young men. A total of 28 young men were divided into 2 groups: control (n = 13) and training (n = 15). In the training group, subjects underwent supervised resistance training for 4 weeks (5 sets of 10 repetitions at 75% of 1-repetition maximum, 3 times/week). CAC and SEVR were then measured in all subjects. In the cross-sectional study, SEVR was significantly positively correlated with CAC, whereas resistance training significantly decreased both SEVR and CAC. Moreover, training-induced changes in CAC were significantly correlated with changes in SEVR. Thus, these results suggest that resistance training-induced decrease in CAC is associated with decreased SEVR in young men.

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MA, ZU-CHANG, YONG-LIANG ZHANG, CHAO-MING NI, ZI-JUN HE, QING-QING CAO, and YI-NING SUN. "A NEW METHOD FOR DETERMINING SUBENDOCARDIAL VIABILITY RATIO FROM RADIAL ARTERY PRESSURE WAVES." Journal of Mechanics in Medicine and Biology 13, no. 04 (July 7, 2013): 1350060. http://dx.doi.org/10.1142/s0219519413500607.

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Aortic subendocardial viability ratio (SEVR), an index of myocardial oxygen demand relative to supply, has been used for the early detection of hemodynamic changes. We aimed to validate a new method for determining SEVR directly from radial pressures. Hemodynamic parameters were measured in 231 outpatients (108 males and 123 females) for physical examination, aged from 20–77 years (45.9 ± 17.3 years), including 210 healthy and 21 hypertensive subjects. Aortic SEVR was obtained using a validated device (SphygmoCor; AtCor Medical, Sydney, Australia), and radial SEVR was obtained using a portable vascular testing device (IIM-2010A; Institute and Intelligent of Machines, Hefei, China). Radial SEVR was strongly related to aortic SEVR (r = 0.824, p < 0.01), with approximately 15.7% lower value. Aortic and radial SEVR had similar independent predictors, including diastolic time fraction (DTF), systolic blood pressure, diastolic blood pressure, age, and height. DTF exerted the most influence on both of them. In healthy subjects, there were significant changes in aortic and radial SEVR between age groups in both males and females (p < 0.05 for both ). Changes in aortic and radial SEVR with aging were parallel though the differences between them increased. These results suggested that the simple and easily obtainable radial SEVR could provide equivalent information to aortic SEVR, and has potential for the primary prevention of cardiovascular disease in health screening.

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Ekart, Robert, Sebastjan Bevc, Nina Hojs, and Radovan Hojs. "Derived Subendocardial Viability Ratio and Cardiovascular Events in Patients with Chronic Kidney Disease." Cardiorenal Medicine 9, no. 1 (November 8, 2018): 41–50. http://dx.doi.org/10.1159/000493512.

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Background: Chronic kidney disease (CKD) is a well-known mortality risk factor. The subendocardial viability ratio (SEVR) is one of the pulse wave analysis parameters that constitutes a non-invasive measure of coronary perfusion. We aimed to assess the prognostic value of the SEVR for cardiovascular outcome in non-dialysis CKD patients. Methods: A total of 98 CKD patients (mean age 60 years) were prospectively followed up from the date of the SEVR measurement until their death or the start of dialysis/transplantation, maximally up to 7.1 years (mean 5 years). According to the manufacturer’s instructions regarding normal SEVR values, the patients were divided into a low SEVR group (SEVR ≤130%, n = 26) and a normal SEVR group (SEVR > 130%, n = 72). Results: During the follow-up period, 13 patients (13.3%) suffered fatal and 23 patients (23.5%) suffered combined (non-fatal and fatal) cardiovascular events. In the patients who died of cardiovascular causes, the SEVR values were statistically significantly lower (130 vs. 154%; p = 0.017) than in those who survived. A Kaplan-Meier survival analysis showed that the cardiovascular survival rate in the low SEVR group of patients was statistically significantly lower (log-rank test: p < 0.001). Using an unadjusted Cox regression analysis, the patients in the low SEVR group had a 5.6-fold higher risk (95% CI: 1.8–17.3; p = 0.002) of fatal cardiovascular events and a 2.7-fold higher risk (95% CI: 1.1–6.3; p = 0.024) of combined fatal and non-fatal cardiovascular events. In the adjusted Cox regression model, the patients in the low SEVR group had a 16-fold higher risk (95% CI: 1.2–9.7; p = 0.004) of fatal cardiovascular events and a 7-fold higher risk (95% CI: 1–9.7; p = 0.009) of combined fatal and non-fatal cardiovascular events. Conclusions: An SEVR < 130% predicts fatal and non-fatal cardiovascular events in non-dialysis CKD patients.

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4

Fantin, Francesco, Anna Giani, Ludovico Gasparini, Andrea P. Rossi, Elena Zoico, Gloria Mazzali, and Mauro Zamboni. "Impaired subendocardial perfusion in patients with metabolic syndrome." Diabetes and Vascular Disease Research 18, no. 6 (November 2021): 147916412110471. http://dx.doi.org/10.1177/14791641211047135.

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Background Metabolic Syndrome (MS) is associated to vascular damage, increased arterial stiffness, and impaired myocardial perfusion. Subendocardial viability ratio (SEVR) is a noninvasive estimation of myocardial workload, oxygen supply, and perfusion. The aim of the study was to describe the relation between arterial stiffness, SEVR, and cardio-metabolic risk factors. Methods A cohort of 55 patients, aged 59.9 ± 10.8 years, was studied; 28 subjects (50.9%) had metabolic syndrome. All patients underwent a clinical evaluation and blood venous sampling, to assess glico-lipid profile. Applanation tonometry was performed, to obtain pulse wave analysis and SEVR values. Results In the overall study population, SEVR showed negative associations with mean (r = −0.301; p = 0.026) and systolic (borderline relation, r = −0.257; p = 0.058) arterial pressure. Metabolic syndrome patients presented lower level of SEVR ( p = 0.012), even after adjusting for age, sex, and mean arterial pressure ( p = 0.040). Subdividing the study population by the number of metabolic syndrome components, SEVR significantly decreased as the number of Metabolic Syndrome components increased ( p for trend 0.005). In a logistic backward regression analysis, both metabolic syndrome and mean arterial pressure resulted significant predictors of SEVR, accounting for 18% of variance. Conclusion The reduced SEVR in metabolic syndrome patients could be an important pathophysiological determinant of the increased cardiovascular risk.

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Turzyniecka, M., S. H. Wild, A. J. Krentz, A. J. Chipperfield, G. F. Clough, and C. D. Byrne. "Diastolic function is strongly and independently associated with cardiorespiratory fitness in central obesity." Journal of Applied Physiology 108, no. 6 (June 2010): 1568–74. http://dx.doi.org/10.1152/japplphysiol.00023.2010.

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Cardiorespiratory fitness [maximal O2 consumption (V̇o2max)] is an independent risk factor for type 2 diabetes; but in individuals at risk, factors influencing V̇o2max are poorly understood. We tested the hypothesis that V̇o2max is associated with diastolic function [subendocardial variability ratio (SEVR), %], as diastolic function influences myocardial perfusion. We studied 47 men and women with central obesity without diabetes. We measured fitness (V̇o2max) by treadmill testing and diastolic function (SEVR%) by pulse-wave analysis. We measured other factors influencing this relationship: insulin sensitivity [whole body glucose uptake-to-insulin concentration ratio (M/I)] by hyperinsulinemic euglycemic clamp, fatness by MR imaging and dual-energy X-ray absorptiometry, physical activity energy expenditure (metabolic equivalents of tasks) by the Sensewear Pro2 device, and muscle microvascular exchange capacity (capillary filtration coefficient) by venous plethysmography. Mean age of the subjects was 51 ± 9 (SD) yr. V̇o2max was associated with SEVR% ( r = 0.50, P = 0.001), fatness ( r = −0.39, P = 0.008), and HbA1c ( r = −0.35, P = 0.018), but not with whole body glucose uptake-to-insulin concentration ratio, metabolic equivalents of tasks, or capillary filtration coefficient. In regression modeling with age, sex, fatness, and SEVR% as explanatory variables, only age, sex, and SEVR% were independently associated with V̇o2max (SEVR% − standardized B coefficient = 0.37, 95% confidence interval = 0.003–0.18, P = 0.007). This model identified 46% of the variance in V̇o2max ( R2 = 0.46, P = 0.0001). There was a strong, independent association between V̇o2max and a measure of diastolic function in sedentary individuals with central obesity.

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Onofrei, Viviana Aursulesei, Alexandr Ceasovschih, Razvan Constantin Anghel, Mihai Roca, Dragos Traian Marius Marcu, Cristina Andreea Adam, Ovidiu Mitu, et al. "Subendocardial Viability Ratio Predictive Value for Cardiovascular Risk in Hypertensive Patients." Medicina 59, no. 1 (December 22, 2022): 24. http://dx.doi.org/10.3390/medicina59010024.

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Background: The subendocardial viability ratio (SEVR), also known as the Buckberg index, is a parameter of arterial stiffness with indirect prognostic value in assessing long-term cardiovascular risk. Materials and Methods: We conducted a prospective cohort study on 70 patients with uncomplicated hypertension admitted to a county medical reference hospital. We analyzed demographics, laboratory data, arterial stiffness parameters and cardiovascular risk scores (SCORE and Framingham risk scores) and aimed to identify paraclinical parameters associated with increased cardiovascular risk. Results: Of the arterial stiffness parameters, SEVR correlates statistically significantly with age, central and peripheral systolic blood pressure, as well as with heart rate. SEVR seems to have prognostic value among hypertensive patients by increasing the risk of major cardiovascular events assessed by SCORE and Framingham risk scores. SEVR correlates statistically significantly with serum fibrinogen (p = 0.02) and hemoglobin (p = 0.046). Between pulse wave velocity and lipid parameters (p = 0.021 for low-density lipoprotein cholesterol <LDL> and p = 0.030 for triglycerides) a statistically significant relationship was found for the study group. The augmentation index of the aorta also correlated with serum LDL-cholesterol (p = 0.032) and the hemoglobin levels (p = 0.040) of hypertensive patients. Conclusions: Age, abdominal circumference and Framingham score are independent predictors for SEVR in our study group, further highlighting the need for early therapeutic measures to control risk factors in this category of patients.

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Liu, Feifan, Richeek Pradhan, Emily Druhl, Elaine Freund, Weisong Liu, Brian C. Sauer, Fran Cunningham, Adam J. Gordon, Celena B. Peters, and Hong Yu. "Learning to detect and understand drug discontinuation events from clinical narratives." Journal of the American Medical Informatics Association 26, no. 10 (April 29, 2019): 943–51. http://dx.doi.org/10.1093/jamia/ocz048.

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Abstract Objective Identifying drug discontinuation (DDC) events and understanding their reasons are important for medication management and drug safety surveillance. Structured data resources are often incomplete and lack reason information. In this article, we assessed the ability of natural language processing (NLP) systems to unlock DDC information from clinical narratives automatically. Materials and Methods We collected 1867 de-identified providers’ notes from the University of Massachusetts Medical School hospital electronic health record system. Then 2 human experts chart reviewed those clinical notes to annotate DDC events and their reasons. Using the annotated data, we developed and evaluated NLP systems to automatically identify drug discontinuations and reasons at the sentence level using a novel semantic enrichment-based vector representation (SEVR) method for enhanced feature representation. Results Our SEVR-based NLP system achieved the best performance of 0.785 (AUC-ROC) for detecting discontinuation events and 0.745 (AUC-ROC) for identifying reasons when testing this highly imbalanced data, outperforming 2 state-of-the-art non–SEVR-based models. Compared with a rule-based baseline system for discontinuation detection, our system improved the sensitivity significantly (57.75% vs 18.31%, absolute value) while retaining a high specificity of 99.25%, leading to a significant improvement in AUC-ROC by 32.83% (absolute value). Conclusion Experiments have shown that a high-performance NLP system can be developed to automatically identify DDCs and their reasons from providers’ notes. The SEVR model effectively improved the system performance showing better generalization and robustness on unseen test data. Our work is an important step toward identifying reasons for drug discontinuation that will inform drug safety surveillance and pharmacovigilance.

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8

Temuçin Faik, ERTAN. "Sevr ve Lozan Antlaşmaları hakkında karşılaştırmalı bir değerlendirme." Ankara Üniversitesi Türk İnkılap Tarihi Enstitüsü Atatürk Yolu Dergisi, no. 58 (2016): 21–37. http://dx.doi.org/10.1501/tite_0000000438.

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9

SAVAGE, M. Tessa, Charles J. FERRO, Sarah J. PINDER, and Charles R. V. TOMSON. "Reproducibility of derived central arterial waveforms in patients with chronic renal failure." Clinical Science 103, no. 1 (June 11, 2002): 59–65. http://dx.doi.org/10.1042/cs1030059.

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Arterial stiffness potently predicts mortality in dialysis patients. Pulse-wave analysis permits the non-invasive assessment of indices of arterial stiffness and the central pressure waveform by applanation tonometry. The aim of this study was to assess the reproducibility of pulse-wave analysis in patients with chronic renal failure. A total of 188 subjects (23 healthy controls, along with 71 pre-dialysis, 67 dialysis and 27 transplant patients) took part. Duplicate measurements were recorded of brachial blood pressure using the semi-automated Omron 705 device and of the radial artery pressure waveform using applanation tonometry. The central pressure aortic waveform was then obtained by application of a transfer function incorporated into the SphygmoCor software. Central aortic mean blood pressure (MBP), indices of arterial stiffness [augmentation index (AIx) and time to reflection (TR)] and the subendocardial viability ratio (SEVR) were analysed for intra-observer, inter-observer and long-term reproducibility using Bland-Altman plots. The mean (±S.D.) intra-observer difference was 0±4% for AIx, 0±20 ms for TR, 0±3 mmHg for aortic MBP and 0±18% for the SEVR. Inter-observer mean differences were 0±3% for AIx, 1±7ms for TR, 1±4mmHg for aortic MBP and 1±9% for the SEVR. For the long-term study, the mean differences were -1±9% for AIx, -2±13mmHg for aortic MBP, -2±12ms for TR and 1±29% for the SEVR. Pulse-wave analysis showed excellent reproducibility in all the studies, and is therefore suitable for use in all patients with chronic renal failure. Further prospective and interventional studies are now required to assess whether AIx and TR are important prognostic indices of cardiovascular events, and therefore relevant surrogate indices of arterial stiffness in this susceptible population.

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10

ŞENER, Bülent. "Sevr Fobisi/Sendromu: Türkiyenin Güvenlik Endişesini Anlamak Üzerine Düşünceler." Journal of Turkish Studies 9, Volume 9 Issue 5 (January 1, 2014): 1835. http://dx.doi.org/10.7827/turkishstudies.6768.

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11

Holewijn, Suzanne, Jenske J. M. Vermeulen, Majorie van Helvert, Lennart van de Velde, and Michel M. P. J. Reijnen. "Changes in Noninvasive Arterial Stiffness and Central Blood Pressure After Endovascular Abdominal Aneurysm Repair." Journal of Endovascular Therapy 28, no. 3 (April 9, 2021): 434–41. http://dx.doi.org/10.1177/15266028211007460.

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Purpose: To evaluate the impact of elective endovascular aneurysm repair (EVAR) on the carotid-femoral pulse wave velocity (cfPWV) and central pressure waveform, through 1-year follow-up. Materials and Methods: A tonometric device was used to measure cfPWV and estimate the central pressure waveform in 20 patients with an infrarenal abdominal aortic aneurysm scheduled for elective EVAR. The evaluated central hemodynamic parameters included the central pressures, the augmentation index (AIx), and the subendocardial viability ratio (SEVR). AIx quantifies the contribution of reflected wave to the central systolic pressure, whereas SEVR describes the myocardial perfusion relative to the cardiac workload. Measurements were performed before EVAR, at discharge, and 6 weeks and 1 year after EVAR. Results: CfPWV was increased at discharge (12.4±0.4 vs 11.3±0.5 m/s at baseline; p=0.005) and remained elevated over the course of 1-year follow-up (6 weeks: cfPWV = 12.2±0.5 m/s; 1 year: cfPWV = 12.2±0.7 m/s, p<0.05). After an initial drop in systolic central pressure at discharge, all the central pressures increased thereafter up to 1 year, without significant differences compared with baseline. The same was observed for the AIx and SEVR. Conclusion: Endovascular aortic aneurysm repair caused an increase in pulse wave velocity compared with baseline, which remained elevated through 1 year follow-up, which may be related to an increased cardiovascular risk. However, no differences in central pressure, augmentation index, and subendocardial viability ration were observed during follow-up.

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Ivanova, Olga S., Elena Yu Maychuk, Svetlana V. Yureneva, and Irina V. Voevodina. "Obstetric and gynecological history and arterial stiffness in women of different age groups." Gynecology 24, no. 2 (April 15, 2022): 108–13. http://dx.doi.org/10.26442/20795696.2022.2.201414.

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Aim. To study the correlation between the features of obstetric and gynecological anamnesis with indicators of arterial stiffness in women of different age groups to assess additional risk factors for the development of cardiovascular diseases. Materials and methods. The single centre study involved women aged 18 to 65 years. The surveyed 161 women were divided into three groups: 1st group 52 young women from 18 to 30 years old; 2nd group 54 women from 31 years old to the onset of menopause; 3rd group 55 postmenopausal women. The 1 and 2nd groups included women with preserved reproductive function. All women underwent a questionnaire survey, clinical examination, determination of anthropometric data, measurement of cfPWV, determination of arterial stiffness by volume sphygmography, 24-hour blood pressure monitoring with assessment of aortic stiffness and characteristics of the central pulse wave. Results. In group 1, the early age of menarche was associated with an increase in the rate of morning rise in SBP (r=-0.46, p=0.002) and a decrease in SEVR (r=0.33, p=0.03); the use of combined oral contraceptives correlates with an increase in the Weissler coefficient PEP/ET (R=0.3, p=0.03) and amplification of pulse pressure PPA (R=0.29, p=0.04). A history of 1 or 2 pregnancies is associated with a decrease in arterial stiffness. At the same time, 3 or more pregnancies in the anamnesis create the prerequisites for the formation of arterial stiffness. The early onset of pregnancy pathologies, namely, starting from the 1st or 2nd trimester of pregnancy, is associated with a violation of the characteristics of the reflected wave at a young age and the formation of arterial stiffness in the menopausal period. History of abortions was associated with PWVao (R=0.45, p=0.002), ASI (R=0.43, p=0.002) in group 2. History of miscarriages is associated with SEVR (R=0.52, p=0.00005) and SEVR to HR75 (R=0.27, p=0.04) in the menopausal period. Conclusion. Pathology of pregnancy, three or more pregnancies in history, early age of menarche, taking combined oral contraceptives, abortions and miscarriages in history are associated with an increase in arterial stiffness in the future, which predisposes women to the development of CVD and should be taken into account for preventive purposes.

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Peker, Mümtaz. "Lozan Konferansı'nda Nüfus Tartışmaları." Belleten 69, no. 256 (December 1, 2005): 1015–46. http://dx.doi.org/10.37879/belleten.2005.1015.

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Cumhuriyet yönetiminin, eğitim kurumu aracılığı ile genç kuşaklara bazı şeyleri iyi öğrettiği gözlemlenmektedir. Bunlardan ilki Sevr Antlaşması'nın ulusun yok oluş belgesi, Lozan Antlaşması'nın ise kurtuluş ve yeniden yapılanma belgesi olduğudur. Ne var ki, her iki antlaşmaya taraf ülkelerin konferans dönemi ve öncesindeki tutumları, davranışları konusunda genç kuşaklara yeterli bilginin aktarıldığını söylemek güçtür. Öte yandan her iki antlaşmanın arka planındaki olaylar üzerine tarafların gelecekte yapabileceği tartışmalar, takınacakları tutumlar üzerine tarihi belgelere dayalı bilgi üretimi de yeterince yapılmamıştır. Bunun günümüzdeki çarpıcı örneği nüfus konusu üzerine yapılan tartışmalarda görülmektedir.

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Madden, Kenneth M., Gale Tedder, and Chris Lockhart. "The oral glucose tolerance test induces myocardial ischemia in healthy older adults." Clinical & Investigative Medicine 30, no. 3 (June 1, 2007): 118. http://dx.doi.org/10.25011/cim.v30i3.1080.

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Purpose: Postprandial myocardial ischemia has been observed in frail older adults with postprandial hypotension and in patients with severe coronary artery disease, especially after high doses of carbohydrates. The impact of oral glucose on myocardial oxygen supply and demand in healthy older adults without postprandial hypotension or postprandial angina remains unexamined. We hypothesized that oral glucose would result in decreased myocardial oxygen supply relative to demand in a healthy older subject pool free of postprandial hypotension, reversible coronary risk factors and postprandial angina. Methods: 19 older adults (mean age 71.9±1.1 yr) were screened for reversible coronary risk factors. Subjects were given a standardized oral glucose load (75 g) or a sham isovolumetric unsweetened drink during two separate sessions. Indirect measures of oxygen supply (Diastolic Pressure Time Index, DPTI) and demand (Rate Pressure Product, RPP; Systolic Pressure Time Index, SPTI) were obtained from aortic arterial blood pressure waveforms. The Subendocardial Viability Ratio (SEVR, DPTI/SPTI) and DPTI/RPP were also calculated. Results: Oral glucose resulted in decreases in both SEVR (P=0.016) and DPTI/RPP (P=0.028) in the glucose session, indicating a decrease in the relative myocardial oxygen supply to demand. This was due solely to a decrease in myocardial oxygen supply while measures of myocardial oxygen demand did not change significantly. Conclusions: Oral glucose decreases myocardial oxygen supply in older adults free of severe coronary artery disease and without postprandial hypotension. This represents a previously unrecognized complication of oral glucose tolerance tests in healthy older adults.

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15

YÜKSEL, Çağdaş. "4 Ağustos 1920 Tarihinde İngiltere Lordlar Kamarası’nda Sevr Antlaşması Hakkında Yapılan Oturum Üzerine Bir Değerlendirme." Gaziantep University Journal of Social Sciences 21, no. 2 (April 30, 2022): 963–76. http://dx.doi.org/10.21547/jss.914046.

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Elemam, Areeg E., Nisreen D. Omer, Neima M. Ibrahim, and Ahmed B. Ali. "The Effect of Dipping Tobacco on Pulse Wave Analysis among Adult Males." BioMed Research International 2020 (October 19, 2020): 1–6. http://dx.doi.org/10.1155/2020/7382164.

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Background. The current study investigated the effect of dipping tobacco (DT) use on arterial wall stiffness which is a known marker of increased risk of cardiovascular events. Methods. A case-control study which included 101 adult males was carried out in Al-Shaab Teaching Hospital. Blood pressure and pulse wave analysis parameters were recorded in 51 DT users (study group) before and after 30 minutes of placing tobacco and in 50 nontobacco users (control group). Anthropometric measurements were collected using data collection sheet. Data were entered into a computer and analyzed by using the software Statistical Package for the Social Sciences (SPSS) version 20 (SPSS Inc., Chicago, IL, USA). Results. At baseline measurements, heart rate (HR) was significantly lower in the study group compared to the control group ( 66.15 ± 9.21 vs. 72.87 ± 10.13 beats/min; P value ≤ 0.001). Subendocardial viability ratio (SEVR) was significantly higher in the study group compared to the control group ( 203.44 ± 30.34 vs. 179.11 ± 30.51 % ; P value ≤ 0.001). Acute effects of DT compared to pretobacco dipping showed significant increase in HR ( 72.50 ± 10.89 vs. 66.15 ± 9.21 beats/min; P value ≤ 0.001) and significant decrease in augmentation pressure (AP) (4.30 (2.30-8.00) vs. 3.30 (0.60-6.3) mmHg; P value ≤ 0.001), ejection duration (ED) ( 271.65 ± 19.42 vs. 279.53 ± 20.47 ms ; P value ≤ 0.001), and SEVR ( 187.11 ± 29.81 vs. 203.44 ± 30.34 ; P value ≤ 0.001). Linear regression analysis for AP predictor showed that only HR and AIx@75 affect and predict the values of AP ( Beta ± SE ; − 0.242 ± 0.019 , P value ≤ 0.001; 0.685 ± 0.014 , P value ≤ 0.001). Conclusions. Long-term use of DT was not associated with permanent changes in heart rate and blood pressure. Acute tobacco dipping caused an acute increase in heart rate and oxygen demands of myocardium.

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Arslan, Esat. "Amerikan İstihbarat Belgelerine Göre Kurtuluş Savaşı'nın Bunalım Dönemindeki Türk Dış Politikası ve "Dışişleri Bakanı Yusuf Kemal Bey'le Yapılan Görüşmeler"." Belleten 62, no. 234 (August 1, 1998): 495–528. http://dx.doi.org/10.37879/belleten.1998.495.

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Kongreler devresinde Ulus'a maledilen ve Son Osmanlı Meclis-i Mebusân'ınca betimlenen "Ulusal Ant" ödün verilmez bir biçimde ortaya konulmuş, Ulus, Meclis ve Ordu bütünüyle bu amaca kilitlenmişti âdeta... Bağlaşık Devletlerin Mondros'la açmış oldukları karta, aynı platformda, koşulları bile tartışılmayacak bir biçimde yanıt verilmişti. Makro seviyede ortaya konulan bu amaçlar doğrultusunda, Türk Dış politikasının genel ilkeleri çerçevesinde örgütlenilerek, dış platformda da, Yeni Türk Devletinin kurumsallaşmasına hız verilmişti. Mondros'tan bu yana 21 ay geçmiş, hilâfet, saltanat ve hanedanın ayrıcalıkları ile hakları uğruna, Osmanlı Devleti'nin paylaşılması demek olan "Doğu Sorunu"nun bütün vecheleri uygulama alanına sokulmuş, ülke bütünlüğünden ödün verilmek suretiyle, Sevr Antlaşması imzalatılmıştı. Türk Kurtuluş Savaşı Sevr'den ödün verdirilmesi için yapılmıyordu, "Ulusal Ant" ile ortaya konulan fizikî coğrafî hedefe adım adım yaklaşılıyordu.

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Gómez-Sánchez, Leticia, Marta Gómez-Sánchez, Cristina Lugones-Sánchez, Emiliano Rodríguez-Sánchez, Olaya Tamayo-Morales, Susana Gonzalez-Sánchez, Rosa Magallón-Botaya, et al. "Long-Term Effectiveness of a Smartphone App and a Smart Band on Arterial Stiffness and Central Hemodynamic Parameters in a Population with Overweight and Obesity (Evident 3 Study): Randomised Controlled Trial." Nutrients 14, no. 22 (November 10, 2022): 4758. http://dx.doi.org/10.3390/nu14224758.

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Background: mHealth technologies could help to improve cardiovascular health; however, their effect on arterial stiffness and hemodynamic parameters has not been explored to date. Objective: To evaluate the effect of a mHealth intervention, at 3 and 12 months, on arterial stiffness and central hemodynamic parameters in a sedentary population with overweight and obesity. Methods: Randomised controlled clinical trial (Evident 3 study). 253 subjects were included: 127 in the intervention group (IG) and 126 in the control group (CG). The IG subjects were briefed on the use of the Evident 3 app and a smart band (Mi Band 2, Xiaomi) for 3 months to promote healthy lifestyles. All measurements were recorded in the baseline visit and at 3 and 12 months. The carotid-femoral pulse wave velocity (cfPWV) and the central hemodynamic parameters were measured using a SphigmoCor System® device, whereas the brachial-ankle pulse wave velocity (baPWV) and the Cardio Ankle Vascular Index (CAVI) were measured using a VaSera VS-2000® device. Results: Of the 253 subjects who attended the initial visit, 237 (93.7%) completed the visit at 3 months of the intervention, and 217 (85.3%) completed the visit at 12 months of the intervention. At 12 months, IG showed a decrease in peripheral augmentation index (PAIx) (−3.60; 95% CI −7.22 to −0.00) and ejection duration (ED) (−0.82; 95% CI −1.36 to −0.27), and an increase in subendocardial viability ratio (SEVR) (5.31; 95% CI 1.18 to 9.44). In CG, cfPWV decreased at 3 months (−0.28 m/s; 95% CI −0.54 to −0.02) and at 12 months (−0.30 m/s, 95% CI −0.54 to −0.05), central diastolic pressure (cDBP) decreased at 12 months (−1.64 mm/Hg; 95% CI −3.19 to −0.10). When comparing the groups we found no differences between any variables analyzed. Conclusions: In sedentary adults with overweight or obesity, the multicomponent intervention (Smartphone app and an activity-tracking band) for 3 months did not modify arterial stiffness or the central hemodynamic parameters, with respect to the control group. However, at 12 months, CG presented a decrease of cfPWV and cDBP, whereas IG showed a decrease of PAIx and ED and an increase of SEVR.

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Sofuoğlu, Adnan, and Seyfi Yıldırım. "1921 Londra Konferansı'nda Türk Diplomasi: Sadrazam A. Tevfik Paşa'nın Sözü Türkiye Büyük Millet Meclisi Temsilcilerine Bırakması Meselesi." Belleten 79, no. 284 (April 1, 2015): 351–82. http://dx.doi.org/10.37879/belleten.2015.351.

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1921 tarihli Londra Konferansı Sevr Antlaşması'nda yapılacak bazı kısmi değişiklikleri görüşmek ve Antlaşmayı taraflara kabul ettirip uygulatmak amacıyla toplanmaktaydı. Türkiye Konferansa Ankara hükümeti İstanbul heyetine dâhil olduğu tek bir heyet olarak davet edilmekteydi. Ancak Ankara hükümeti uyguladığı diplomatik girişimlerin neticesinde müstakil bir heyet olarak Konferansa katılmayı başardı. Konferans görüşmelerinde Sadrazam A. Tevfik Paşa'nın sözü Ankara heyetine bırakması hususu çeşitli kaynaklarda oldukça farklı şekillerde zikredilmekte ve gerçeğinden oldukça farklı bir şekilde algılanmaktadır. Bu husus ilgili literatür ve çeşitli arşiv belgeleri kapsamında incelendiğinde A. Tevfik Paşa'nın ve Osmanlı heyetinin diğer üyelerinin Konferans müzakerelerinde "sözün tamamen Ankara Hükümetine bırakılması" olarak algılanan tavrının ancak kendilerini ifade ettikten sonra "sözün Ankara hükümetinin delegelerine devredilmesi" şeklinde Türk tarafının ortaya koyduğu ortak bir diplomatik tavır olduğu anlaşılmaktadır. Nitekim konferans boyunca Türk tarafından katılan her iki heyet temsilcileri de söz almışlardır. Oturumlarda birbiri ardınca söz almışlar ve söylemleri birbirlerini tamamlar nitelikte olmuştur. Konferansta bu şekildeki ortak bir tutum ise İtilaf Devletleri arasındaki ihtilafları arttırarak, Milli Mücadele lehinde önemli gelişmelerin ortaya çıkmasını sağlayacaktır.

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Melnikov, Vladimir N., Victor I. Baranov, Irina Yu Suvorova, and Sergey G. Krivoschekov. "Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population." Physiological Genomics 50, no. 2 (February 1, 2018): 100–101. http://dx.doi.org/10.1152/physiolgenomics.00071.2017.

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The ADRA2B gene 301–303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 residents of the Kola Peninsula (68 N) aged 27–65 yr. The genotypes were determined by PCR. The paired comparisons revealed that II genotype carriers had higher values of augmentation index ( P = 0.014), ejection duration ( P = 0.045), and lower SEVR ( P = 0.035) than DD homozygotes. Multiple regression analysis adjusted for age, body mass index, heart rate, and blood pressure confirmed these results. Further sex stratified analysis showed that the associations existed only in men ( n = 33) whereas in women ( n = 30) the differences were suggestive ( P < 0.1). It is concluded that in a northern Russian population men carrying I allele have stiffer arteries, shorter diastole duration, and impaired coronary perfusion and seem to be at higher risk for cardiovascular diseases than DD carriers.

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Lin, Hsin-Fu, Ching-Ying Tseng, Toby Mündel, Yi-Yuan Lin, Chung-Chi Lin, Chiao-Nan Chen, and Yi-Hung Liao. "Perturbations of Adjuvant Chemotherapy on Cardiovascular Responses and Exercise Tolerance in Patients with Early-Stage Breast Cancer." Biology 10, no. 9 (September 13, 2021): 910. http://dx.doi.org/10.3390/biology10090910.

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Background: Adjuvant chemotherapies are commonly used for treating early-stage breast cancer. However, whether chemotherapeutic regimens affect exercise tolerance and cardiovascular responses remains unclear. Therefore, we investigated the effects of receiving CAF and AC-T on exercise tolerance and cardiovascular responses in patients with early-stage breast cancer. Methods: Thirty-four patients with breast cancer (age: 44 ± 1 years; stage I-II) received either CAF (n = 15) or AC-T (n = 19), depending on clinical decisions. Their step-exercise tolerance and cardiovascular responses were assessed before and after chemotherapy. Results: After chemotherapy, there were no differences in baseline measurements between patients receiving CAF or AC-T. The increases in resting heart rate (RHR) of those receiving AC-T was significantly greater than that of those receiving CAF. CAF and AC-T did not result in increased pulse wave velocity (PWV), yet the subendocardial viability ratio (SEVR) in patients receiving AC-T was significantly lower than the baseline. Greater change in post-exercise heart rate recovery (recovery HR) after chemotherapy was observed in those who had received AC-T; the Recovery HR in AC-T patients was significantly higher during post-exercise period than that in CAF patients. Conclusions: AC-T chemotherapy increases RHR and impairs exercise tolerance after chemotherapy more than CAF. Moreover, AC-T also lowers myocardial perfusion more than CAF after chemotherapy.

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Dhar, Biplab, Praveen Kumar Gupta, and Mohammad Sajid. "Solution of a dynamical memory effect COVID-19 infection system with leaky vaccination efficacy by non-singular kernel fractional derivatives." Mathematical Biosciences and Engineering 19, no. 5 (2022): 4341–67. http://dx.doi.org/10.3934/mbe.2022201.

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<abstract><p>In this paper, the recent trends of COVID-19 infection spread have been studied to explore the advantages of leaky vaccination dynamics in SEVR (Susceptible Effected Vaccinated Recovered) compartmental model with the help of <italic>Caputo-Fabrizio</italic> (CF) and <italic>Atangana-Baleanu derivative in the Caputo sense</italic> (ABC) non-singular kernel fractional derivative operators with memory effect within the model to show possible long–term approaches of the infection along with limited defensive vaccine efficacy that can be designed numerically over the closed interval ranging from 0 to 1. One of the main goals is to provide a stepping information about the usefulness of the aforementioned non-singular kernel fractional approaches for a lenient case as well as a critical case in COVID-19 infection spread. Another is to investigate the effect of death rate on state variables. The estimation of death rate for state variables with suitable vaccine efficacy has a significant role in the stability of state variables in terms of basic reproduction number that is derived using next generation matrix method, and order of the fractional derivative. For non-integral orders the pandemic modeling sense viz, CF and ABC, has been compared thoroughly. Graphical presentations together with numerical results have proposed that the methodology is powerful and accurate which can provide new speculations for COVID-19 dynamical systems.</p></abstract>

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Geronikolou, Styliani, Flora Bacopoulou, Stavros Chryssanthopoulos, Dennis V. Cokkinos, and George P. Chrousos. "Hypertension Predisposition and Thermoregulation Delays in Adolescents with Polycystic Ovary Syndrome: A Pilot Study." Children 9, no. 3 (February 25, 2022): 316. http://dx.doi.org/10.3390/children9030316.

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Background: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder in which clinical, sonographic, and endophenotypic features have been underinvestigated or inconclusive, especially in the early stages of the disease (adolescence/young adulthood). Objective: This prospective pilot study focused on the differences of multiple physiological functions between Greek adolescent/young adult females suffering from PCOS and age- and body mass index (BMI)- matched healthy controls. Study design: Nineteen PCOS patients and eighteen healthy controls (aged 13 to 23 years) were studied for: (i) biochemical and hormonal dysfunction by measuring circulating glucose, insulin, and androgen levels; (ii) arterial stiffness with pulse wave analysis (PWA) by Sphygmocord; (iii) intima-media thickness (IMT) by ultrasound; (iv) heart rate variability (HRV) by Task Force Monitor; and (v) QT, QRS, QT, P, QRSD by electrocardiogram (ECG). Statistical analysis included Hedge’s g correction for small samples bias, and the results are shown using the Hedge’s g effect size and 95% CI, in line with precision medicine prerequisites. Results: Significant differences in pulse wave velocity (PWV) (g = 0.964 [0.296, 1.632]), subendocardial viability ratio (SEVR) carotid (g = −0.679 [−1.329, −0.030]), pulse pressure (PP) carotid (g = 0.942 [0.275, 1.608]), systolic pressure (SP) carotid (g = 0.785 [0.129, 1.440]), free-testosterone (g = 0.677 [0.042, 0.312]), and Delta4-androstenedione (g = 0.735 [0.097, 0.373]) were observed between PCOS patients and controls. No differences were detected in the remaining endocrine and PWA or ECG biomarkers. Conclusions: Our multidisciplinary approach showed early onset of vascular dysfunction, predisposition to hypertension, thermoregulation delays, and metabolic syndrome changes in adolescent/young adult PCOS.

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Carichino, Lucia, Giovanna Guidoboni, Alice Chandra Verticchio Vercellin, Giovanni Milano, Carlo Alberto Cutolo, Carmine Tinelli, Annalisa De Silvestri, et al. "Computer-aided identification of novel ophthalmic artery waveform parameters in healthy subjects and glaucoma patients." Modeling and Artificial Intelligence in Ophthalmology 1, no. 2 (December 15, 2016): 59–69. http://dx.doi.org/10.35119/maio.v1i2.31.

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Purpose: Arterial waveform parameters (WPs) are commonly used to monitor and diagnose systemic diseases. Color Doppler Imaging (CDI) is a consolidated technique to measure blood velocity profile in some of the major ocular vessels. This study proposes a computer-aided manipulation process of ophthalmic artery (OA) CDI images to classify and quantify WPs that might be significant in the assessment of glaucoma.Methods: Fifty CDI images acquired by four different operators on nine healthy individuals and 38 CDI images of 38 open-angle glaucoma (OAG) patients were considered. An ad-hoc semi-automated image processing code was implemented to detect the digitalized OA velocity waveform and to extract the WPs. Concordance correlation coefficient (CCC), two-sample t-test and Pearson’s correlation coefficient were used to test for similarities, differences and associations among variables.Results: The OA-CDI images manipulation proposed showed a higher concordance between measured peak systolic velocity (PSV) data and extracted PSV data (0.80≤CCC≤0.98) than on end diastolic velocity (EDV) (0.45≤CCC≤0.63) and resistive index (RI) (0.30≤CCC≤0.58) data. In OAG patients, EDV, RI, subendocardial viability ratio (SEVR), period (T), area ratio (f) and normalized distance between ascending and descending limb (DAD/T) were found statistically correlated to at least one of the following factors: gender, age, ocular medications and year of diagnosis. When compared to healthy individuals, OAG patients OA-CDI profiles showed statistically higher values of f (p < 0.001) and DAD/T (p = 0.002) (p-values corrected by age and gender).Conclusion: The proposed computer-aided manipulation of OA-CDI images allowed to identify DAD/T as a novel WP that vary significantly among healthy individuals and OAG patients, and among female and male OAG patients. Future studies on longitudinal OAG data are suggested to investigate the potential of DAD/T to predict severity and progression of the disease.

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Pachane, Bianca Cruz, Ana Carolina Caetano Nunes, Thais Regiani Cataldi, Kelli Cristina Micocci, Bianca Caruso Moreira, Carlos Alberto Labate, Heloisa Sobreiro Selistre-de-Araujo, and Wanessa Fernanda Altei. "Small Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells Induce Oxygen-Dependent Cell Invasion." International Journal of Molecular Sciences 23, no. 20 (October 21, 2022): 12646. http://dx.doi.org/10.3390/ijms232012646.

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Hypoxia, a condition of low oxygenation frequently found in triple-negative breast tumors (TNBC), promotes extracellular vesicle (EV) secretion and favors cell invasion, a complex process in which cell morphology is altered, dynamic focal adhesion spots are created, and ECM is remodeled. Here, we investigated the invasive properties triggered by TNBC-derived hypoxic small EV (SEVh) in vitro in cells cultured under hypoxic (1% O2) and normoxic (20% O2) conditions, using phenotypical and proteomic approaches. SEVh characterization demonstrated increased protein abundance and diversity over normoxic SEV (SEVn), with enrichment in pro-invasive pathways. In normoxic cells, SEVh promotes invasive behavior through pro-migratory morphology, invadopodia development, ECM degradation, and matrix metalloprotease (MMP) secretion. The proteome profiling of 20% O2-cultured cells exposed to SEVh determined enrichment in metabolic processes and cell cycles, modulating cell health to escape apoptotic pathways. In hypoxia, SEVh was responsible for proteolytic and catabolic pathway inducement, interfering with integrin availability and gelatinase expression. Overall, our results demonstrate the importance of hypoxic signaling via SEV in tumors for the early establishment of metastasis.

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Punin, D. A. "Effect of the combination of a short-acting β2-agonist plus an anticholinergic drug on the efficacy of coronary blood flow measured by applanation tonometry in chronic obstructive pulmonary disease." Russian Medical Inquiry 4, no. 4 (2020): 199–206. http://dx.doi.org/10.32364/2587-6821-2020-4-4-199-206.

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Background: bronchodilators are the major class of drugs prescribed for chronic obstructive pulmonary disease (COPD). Meanwhile, treatment strategies for obstructive lung disease using bronchodilators are continually discussed and reviewed, in particular, with regard to their potential effect on cardiovascular system. Aim: to evaluate the effect of the combination of a short-acting β2-agonist plus an anticholinergic medication (fenoterol 50 μg/dose + ipratropium bromide 20 μg/dose, 2 doses) on the efficacy of coronary blood flow in COPD patients. Patients and Methods: spirometry with bronchodilator testing (at least 12 hours after using the medication) was performed in 30 COPD patients. The efficacy of coronary blood flow was assessed by central subendocardial viability ratio (C_SEVR) measured by applanation tonometry which was performed before and 15, 30, and 60 min after using the bronchodilator. Oxygen saturation was measured at all stages of the study. Results: the combination of fenoterol and ipratropium bromide resulted in the increase of C_SEVR by 9.5 [3.3; 10.8]% in patients with low oxygen saturation at baseline due to heart rate reduction, diastolic lengthening, and oxygen level improvement. The timing of the effect was determined by the reversibility of bronchial obstruction. No effects of the combination of fenoterol and ipratropium bromide on central and peripheral blood pressure were reported. Conclusion: low oxygen saturation at baseline and reversible bronchial obstruction in COPD patients allow for a favorable predicted systemic effect of the combination of fenoterol and ipratropium bromide. When using in therapeutic dosages and according to recommended dosage regimen, this combination improves bronchopulmonary function, oxygen saturation, and the efficacy of coronary blood flow measured by applanation tonometry. KEYWORDS: chronic obstructive pulmonary disease, applanation tonometry, central subendocardial viability ratio, SEVR, bronchial obstruction, oxygen saturation. FOR CITATION: Punin D.A. Effect of the combination of a short-acting β2-agonist plus an anticholinergic drug on the efficacy of coronary blood flow measured by applanation tonometry in chronic obstructive pulmonary disease. Russian Medical Inquiry. 2020;4(4):199–206. DOI: 10.32364/2587-6821-2020-4-4-199-206.

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Aliyeva, Nurlana. "Armenian claims to Nakhchivan and its impact to the historical geography of the region (1918–1924s years)." Grani 23, no. 3 (March 10, 2020): 147–54. http://dx.doi.org/10.15421/172034.

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Azerbaijan People Republic the new sovereign state, created in May 1918 in the Muslim East, has lived and worked in hard and difficult conditions for 23 months. The Republic had to fight against the political and economic policies of the world's major powers, including Russia, the United States, England and France, and resorted to all means to maintain its sovereignty, and faced very complex challenges along the way. Under the pressure of these states, on May 29, 1918, the National Council of Azerbaijan was forced to decide on the issue of Iravan to the armenians in order to maintain their sovereignty while discussing the border problem between Azerbaijan and Armenia and he considered this decision a "historic necessity", a "unavoidable disaster" for heartbreak. During the Azerbaijan People Republic, neighboring countries made a number of territorial claims against Azerbaijan. At that time, its territory was 113.895, 97 sq. km. Its 97,296,67 sq. km was undeniable, and 16,598,30 sq. km was disputed. To resolve such issues, the Treaty of Friendship was first signed on June 4, 1918, between the Ottoman Empire and the Republic of Azerbaijan. It was the first agreement signed by the Azerbaijan People Republic with any foreign state. The second article of the Batumi Treaty sets the border between Azerbaijan, Georgia and Armenia. According to the Batumi contract, Azerbaijan also suffered territorial losses. According to the agreement, the Sharur section of the Sharur-Daralayaz province and the Nakhchivan accident, except for Ordubad, were transferred to Turkey. In addition, the regions of Kamarly, Ulukhanli and Vedibasar of the Iravan provincewere transferred to Turkey. On March 12, 1921, the Moscow Treaty was signed. With the participation of a representative of the Soviet Russia to clarify some of the territories following the Moscow Treaty, Turkey signed an agreement on October 13, 1921, between the three South Caucasus republics. With the participation of a representative of the Soviet Russia to clarify some of the territories following the Moscow treaty, Turkey signed an agreement on October 13, 1921, between the three South Caucasus republics. The contract consisted of 20 articles and 3 annexes. A number of provisions of this treaty were consistent with the relevant articles of the Moscow Treaty. In general, this document was rejecting unequal rights, forcible contracts, and the Sevr treaty. Article 5 of the agreement was directly related to the fate of Nakhchivan. Thus, the Moscow and Kars treaties also resolved Nakhchivan's autonomy status.

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Umapathy, Kalpana, Balaganesan Palanivelu, Renuka Jayaraj, Dumitru Baleanu, and Prasantha Bharathi Dhandapani. "On the decomposition and analysis of novel simultaneous SEIQR epidemic model." AIMS Mathematics 8, no. 3 (2022): 5918–33. http://dx.doi.org/10.3934/math.2023298.

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<abstract><p>In this manuscript, we are proposing a new kind of modified Susceptible Exposed Infected Quarantined Recovered model (SEIQR) with some assumed data. The novelty imposed here in the study is that we are studying simultaneously SIR, SEIR, SIQR, and SEQR pandemic models with the same data unchanged as the SEIQR model. We are taking this model a step ahead by using a non-helpful transition because it was mostly skipped in the literature. All sorts of features that are essential to study the models, such as basic reproduction number, stability analysis, and numerical simulations have been examined for this modified SEIQR model with decomposed other epidemic models.</p></abstract>

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Diegues, Nuno, Paolo Romano, and Stoyan Garbatov. "Seer." ACM Transactions on Computer Systems 35, no. 3 (December 29, 2017): 1–41. http://dx.doi.org/10.1145/3132036.

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Merwin, Kathryn. "Sear." Minnesota review 2016, no. 87 (2016): 35. http://dx.doi.org/10.1215/00265667-3630748.

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Liu, Xiaotao, Mark Corner, and Prashant Shenoy. "SEVA." ACM Transactions on Multimedia Computing, Communications, and Applications 5, no. 3 (August 2009): 1–26. http://dx.doi.org/10.1145/1556134.1556141.

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Keck, Tobias. "Sehr geehrte Leserinnen, sehr geehrte Leser,." Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie 147, no. 04 (August 2022): 353. http://dx.doi.org/10.1055/a-1864-2409.

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Wahl, Gerhard. "Sehr verehrte Kolleginnen, sehr verehrte Kollegen,." Zahnmedizin up2date 12, no. 03 (June 2018): 183–84. http://dx.doi.org/10.1055/a-0594-4269.

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Althuber, Franz, Mario Felice, Alexander Lang, Stefan Schuster, and Michael Tanzer. "Sehr geehrte Leserin, sehr geehrter Leser,." Zeitschrift für Steuerstrafrecht und Steuerverfahren 2, no. 2 (2020): 89. http://dx.doi.org/10.33196/zss202002008901.

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Raschke, Michael, Florian Gebhard, and Ulrich Stöckle. "Sehr geehrte Leserin, sehr geehrter Leser,." OP-JOURNAL 33, no. 03 (December 2017): 205. http://dx.doi.org/10.1055/s-0043-115230.

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Bartenstein, Martin. "Sehr geehrte Leserinnen, sehr geehrte Leser!" e & i Elektrotechnik und Informationstechnik 121, no. 11 (November 2004): 403. http://dx.doi.org/10.1007/bf03053994.

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Rabensteiner, Günther. "Sehr geehrte Leserinnen, sehr geehrte Leser." e & i Elektrotechnik und Informationstechnik 122, no. 12 (December 2005): a1. http://dx.doi.org/10.1007/bf03054391.

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Reichel, Peter. "Sehr geehrte Leserinnen, sehr geehrte Leser." e & i Elektrotechnik und Informationstechnik 121, no. 12 (December 2004): a1. http://dx.doi.org/10.1007/bf03055414.

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Wahl, Gerhard. "Sehr geehrte Damen, sehr geehrte Herren, sehr verehrte Kolleginnen und Kollegen,." Zahnmedizin up2date 13, no. 03 (June 2019): 183–84. http://dx.doi.org/10.1055/a-0873-6992.

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Conceição, Maria Inês Gandolfo. "SEER ou não SEER? Eis a questão." Psicologia: Teoria e Pesquisa 22, no. 2 (August 2006): iii. http://dx.doi.org/10.1590/s0102-37722006000200001.

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Abreu-Rodrigues, Josele. "Plataforma SEER." Psicologia: Teoria e Pesquisa 25, no. 3 (September 2009): v. http://dx.doi.org/10.1590/s0102-37722009000300001.

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Schreiber, Melvyn H. "The Seer." Investigative Radiology 28, no. 8 (August 1993): 777. http://dx.doi.org/10.1097/00004424-199308000-00023.

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Greenemeier, Larry. "Professional Seer." Scientific American 306, no. 5 (April 17, 2012): 80–83. http://dx.doi.org/10.1038/scientificamerican0512-80.

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Sniecinski, Roman M., and Kenichi A. Tanaka. "SEER Sonorheometry." Anesthesia & Analgesia 123, no. 6 (December 2016): 1346–47. http://dx.doi.org/10.1213/ane.0000000000001587.

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Hirschmüller, Anja. "M. Sever." Sports Orthopaedics and Traumatology 35, no. 1 (March 2019): 63–65. http://dx.doi.org/10.1016/j.orthtr.2019.01.013.

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mf. "„Sehr gut!“." Der Freie Zahnarzt 60, no. 5 (April 30, 2016): 75. http://dx.doi.org/10.1007/s12614-016-6251-9.

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Gehrmann, Reinhard. "Sehr Aktiv." Versicherungsmagazin 47, no. 7 (July 2000): 54–55. http://dx.doi.org/10.1007/bf03247848.

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Rieke, Burkhard. "Sehr geehrte Frau Kollegin, sehr geehrter Herr Kollege!" Flugmedizin · Tropenmedizin · Reisemedizin - FTR 26, no. 06 (December 2019): 275. http://dx.doi.org/10.1055/a-1011-5165.

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Friis, Lykke. "Merkels sidste sejr." Udenrigs, no. 3 (January 14, 2020): 74–81. http://dx.doi.org/10.7146/udenrigs.v0i3.118111.

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Keshawarz, Amena, Martin Cech, Elizabeth Westfeldt, Gregory L. Kinney, and Janet Snell-bergeon. "Abstract P445: Pulmonary Function is Associated With the Subendocardial Viability Ratio." Circulation 141, Suppl_1 (March 3, 2020). http://dx.doi.org/10.1161/circ.141.suppl_1.p445.

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Abstract:

Introduction: Pulmonary function is reduced and arterial stiffening is increased in type 1 diabetes. While increased arterial stiffness is associated with greater risk of cardiovascular disease in type 1 diabetes, the association between reduced pulmonary function and health outcomes in this population is less understood. The subendocardial viability ratio (SEVR), a ratio comparing myocardial perfusion to cardiac workload, may provide useful information pulmonary function and myocardial hypoxemia in the context of pulmonary function in type 1 diabetes. Hypothesis: We tested the hypothesis that impaired pulmonary function (i.e., percent predicted forced vital capacity [FVCpp], forced expiratory volume at 1 second [FEV 1 pp], and FEV 1 /FVC), is associated with reduced SEVR in adults with and without type 1 diabetes. Methods: We conducted pulse wave analysis on 208 adults with type 1 diabetes (mean age 52±9 years) and 285 adults without diabetes (mean age 55±8 years) to obtain the outcome measure of SEVR. All participants underwent non-bronchodilated spirometry testing to obtain FVCpp, FEV 1 pp, and FEV 1 /FVC. Independent t-tests were used to test the difference by diabetes status in each pulmonary function measure and the SEVR. Linear regression models were used to test the association between each pulmonary function measure and SEVR after adjustment for age, sex, diabetes status, smoking status, and heart rate. Results: FVCpp and FEV 1 pp were both significantly lower in type 1 diabetes (87.5% and 85.6%, respectively) compared to controls without diabetes (95.6% and 94.9%, respectively; p<0.001 for both). There was no significant difference by diabetes status in FEV 1 /FVC (97.5% vs. 99.0%, p=0.07). SEVR was also significantly lower in type 1 diabetes (137.5 vs. 159.6, p<0.001). In an adjusted linear model, both FVCpp and FEV 1 pp were associated with SEVR. FVCpp was associated with 0.086 greater SEVR per SD (p=0.002), and FEV 1 pp was associated with 0.058 greater SEVR per SD (p=0.04). FEV 1 /FVC was not significantly associated with SEVR (p=0.37). In the model testing FVCpp, type 1 diabetes was associated with 0.18 lower SEVR (p<0.001). Similarly, in the model testing FEV 1 pp, type 1 diabetes was associated with 0.19 lower SEVR (p<0.001). After accounting for FEV 1 /FVC, type 1 diabetes was still associated with 0.20 lower SEVR (p<0.001). Conclusions: In conclusion, reduced pulmonary function was associated with reduced SEVR in cross-sectional analysis, but type 1 diabetes remained independently associated with reduced SEVR after accounting for reduced pulmonary function. The mechanism between pulmonary function and SEVR is unclear, but future research may reveal pathways or shared etiologies in type 1 diabetes.

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