Relevant bibliographies by topics / Severity of liver damage

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Academic literature on the topic 'Severity of liver damage'

Author: Grafiati
Published: 28 September 2024

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Journal articles on the topic "Severity of liver damage"

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Farzana, Taposhi, Pijush Karmakar, Jakia Haque, Md Farhan Joha, and Eshrat Jahan Eami. "Study Of Serum Triglyceride And Ldl-cholesterol Among Patients Suffereing From Liver Cirrhosis And Its Relation With Severity of The Disease." Central Medical College Journal 5, no. 1 (June 12, 2022): 25–29. http://dx.doi.org/10.3329/cemecj.v5i1.60201.

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Background: Cirrhosis is characterized by abnormal structure and function of the liver. Liver synthesizes the various lipoproteins involved in transporting cholesterol and lipids throughout the body. This makes liver an important site for lipid metabolism as well as its transport. Thus liver cirrhosis is associated with lipid abnormalities and the amount of decrement is expected to be significantly correlated with increasing severity of liver damage. Aims and objectives: To determine serum TG and LDL-C in patients with cirrhosis and study their relationship to the severity of cirrhosis. Materials & Method: This cross-sectional study was carried out in the Department of Biochemistry, Sylhet MAG Osmani Medical College, Sylhet during the period from January to December 2016. Fifty cirrhosis of liver patients fulfilling the inclusion criteria were enrolled as group-A and 50 age-sex matched healthy adults were selected as the control group (group-B). Result: Fasting serum TG and LDL-C were estimated. Severity of liver Cirrhosis was categorized according to Child-Pugh scoring system and increasing severity was categorized as Child Pugh class A, B and C. TG and LDL-C were decreased in patients with liver cirrhosis. The level of severity of liver damage significantly affects the serum LDL-C level in cirrhosis; and may be considered as marker of severity of liver damage in cirrhosis. Conclusion: It may be concluded that hypolipidemia exists in patients with liver cirrhosis and screening for severity of cirrhosis by LDL-C is important for intervention with appropriate therapy to reduce the severity of the disease. Central Medical College Journal Vol 5 No 1 Jan 2021 PP 25-29
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Spogis, Jakob, Florian Hagen, Wolfgang M. Thaiss, Tatjana Hoffmann, Nisar Malek, Konstantin Nikolaou, Christoph P. Berg, et al. "Sonographic findings in coronavirus disease-19 associated liver damage." PLOS ONE 16, no. 2 (February 19, 2021): e0244781. http://dx.doi.org/10.1371/journal.pone.0244781.

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Purpose This study was conducted to evaluate the role of liver sonography in patients with coronavirus disease 2019 (COVID-19) and elevated liver enzymes. Materials and methods In this retrospective study, patients tested positive for SARS-CoV-2 in our emergency ward between January 01 and April 24, 2020 and elevated liver enzymes were included (Cohort 1). Additionally, the local radiology information system was screened for sonographies in COVID-19 patients at the intensive care unit in the same period (Cohort 2). Liver sonographies and histologic specimen were reviewed and suspicious findings recorded. Medical records were reviewed for clinical data. Ultrasound findings and clinical data were correlated with severity of liver enzyme elevation. Results Cohort 1: 126 patients were evaluated, of which 47 (37.3%) had elevated liver enzymes. Severity of liver enzyme elevation was associated with death (p<0.001). 8 patients (6.3%) had suspicious ultrasound findings, including signs of acute hepatitis (n = 5, e.g. thickening of gall bladder wall, hepatomegaly, decreased echogenicity of liver parenchyma) and vascular complications (n = 4). Cohort 2: 39 patients were evaluated, of which 14 are also included in Cohort 1. 19 patients (48.7%) had suspicious ultrasound findings, of which 13 patients had signs of acute hepatitis and 6 had vascular complications. Pathology was performed in 6 patients. Predominant findings were severe cholestasis and macrophage activation. Conclusion For most hospitalized COVID-19 patients, elevated liver enzymes cause little concern as they are only mild to moderate. However, in severely ill patients bedside sonography is a powerful tool to reveal different patterns of vascular, cholestatic or inflammatory complications in the liver, which are associated with high mortality. In addition, macrophage activation as histopathologic correlate for a hyperinflammatory syndrome seems to be a frequent complication in COVID-19.
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Effenberger, Maria, Christoph Grander, Gernot Fritsche, Rosa Bellmann-Weiler, Frank Hartig, Sophie Wildner, Stefanie Seiwald, et al. "Liver stiffness by transient elastography accompanies illness severity in COVID-19." BMJ Open Gastroenterology 7, no. 1 (July 2020): e000445. http://dx.doi.org/10.1136/bmjgast-2020-000445.

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ObjectiveSevere liver damage is associated with worse outcome in COVID-19. Our aim was to explore the degree of liver damage, liver stiffness (LS) and severity of illness in patients with COVID-19.DesignWe investigated 32 patients with COVID-19 admitted to the University Hospital of Innsbruck in a prospective cross-sectional study. We performed laboratory testing, liver and spleen sonography and elastography to measure organ stiffness.Results12 patients (38%) showed elevated aminotransferases and gamma-glutamyltransferase levels. LS was positively correlated with elevated aminotransferase levels in patients with COVID-19 compared with those without elevated enzymes. Even mild liver damage raised LS significantly in COVID-19 as it was in patients with gastrointestinal symptoms. Furthermore, higher LS measurements were significantly associated with illness severity like pneumonia, need for mechanical ventilation, and even death.ConclusionTransient elastography is a useful and non-invasive tool to assess onset and severity of acute liver injury in patients with COVID-19 patients. Increased LS seems to be predictive for a more severe and complicated course of disease.
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Casey, Carol A., Benita L. McVicker, Terrence M. Donohue, Melinda A. McFarland, Robert L. Wiegert, and Amin A. Nanji. "Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats." Journal of Applied Physiology 96, no. 1 (January 2004): 76–80. http://dx.doi.org/10.1152/japplphysiol.00375.2003.

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It has been demonstrated that the oral administration of ethanol (Lieber-DeCarli liquid diet) to rats results in a decreased expression and content of the asialoglycoprotein receptor (ASGP-R) in the resultant fatty liver. In the present study, we wanted to determine whether the extent of impaired receptor content was correlated with the severity of liver pathology by using the intragastric feeding model. When ASGP-R protein and mRNA levels were measured in animals infused with ethanol or dextrose in the presence of fish oil (FO) or medium-chain triglyceride as the source of fat, more significant impairments to the ASGP-R were observed in the FO-ethanol group compared with the medium-chain triglyceride-ethanol group. Furthermore, only the FO-ethanol group showed pathological liver changes. These results demonstrate that a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content.
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Sayfullin, M. A., N. N. Zvereva, E. A. Nurmuhametova, N. P. Blohina, E. Yu Pylaeva, K. S. Konyaev, and O. V. Shamsheva. "Liver damage with measles." Journal Infectology 12, no. 4 (October 17, 2020): 78–86. http://dx.doi.org/10.22625/2072-6732-2020-12-4-78-86.

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Objective: to determine the incidence of liver damage with measles, the specificity of these changes, to identify risk groups, to assess the dynamics of the development of hyperfermentemia in various stages of the disease.Materials and methods: a retrospective cohort study of medical records of patients hospitalized with measles (n = 101), divided into 4 groups: children (n = 23), men (n = 32), women (n = 24) and pregnant women (n = 22). Patients with laboratory-confirmed influenza (n = 61) were taken as a comparison group. The analysis of the frequency of detecting changes in biochemical parameters, average values, standard error and confidence intervals.Results: An increase in ALT in measles patients was observed in 56 (55.4%), above 5 norms – in 15 patients (14.8%), an increase in AST was detected in 80 (79.2%) patients, above 5 norms – in 10 (9.9%). These changes are specific for measles, which was established by comparing the indicators of patients with measles and influenza. The greatest frequency and severity of the observed changes was observed in men. Determination of bilirubin concentration was carried out in 95 patients. An increase in total bilirubin above 20 μmol / L was observed in 10 (10.5%), direct above 5 μmol / L – in 13 (13.6%) patients.Conclusion: given the frequency of occurrence of the identified changes, it is advisable to conduct a biochemical blood test for measles patients. Therapeutic tactics should be determined taking into account the possible development of hepatitis with measles.
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Dhefer, Iqbal Hanash. "Liver damage during infections with coronavirus." Journal of Techniques 3, no. 2 (June 30, 2021): 79–85. http://dx.doi.org/10.51173/jt.v3i2.302.

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The pathogen of the new 2019 coronavirus disease (COVID-19), the sever acute respiratory syndrome coronavirus 2 (SARS-Cov-2), presented a significant risk to health care. The WHO has described the SARS-CoV-2 infection outbreak as an international public health emergency. The main damage caused by the infection with SARS-CoV-2 was known to be lung infections. Previous research revealed that liver damage is prevalent in patients infected with the additional widely zoonotic coronaviruses, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), and has been reviewed in relation to the severity of MERS, SARS, and COVID-19 diseases. Likewise, the mechanism and features of liver damage and liver injury has also been observed, as outlined in this review, which results in extreme cases during the phases of the disease.
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T.Farzana, T.F.Chowdhury, S.K Mandal, R.A. Saeed, and B.R. Rehan. "Study of Serum Total Cholesterol in Cirrhosis of Liver And Its Relation With Severity of The Disease." Journal of Sylhet Women’s Medical College 11, Number 1 (January 1, 2021): 33–38. http://dx.doi.org/10.47648/jswmc2021v11-04.

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Background: Lipid metabolism is impaired in different directions in liver cirrhosis. Dyslipidaemia seen in cirrhosis of the liver differs from that found in most of the additional reasons of secondary dyslipidaemias because lipoproteins in circulation are not only present in unusual amount but they also often have unusual composition, electrophoretic movement and forms (Nangliya et al., 2015). Materials & Method: This cross-sectional study was carried out in the Department of Biochemistry, Sylhet MAG Osmani Medical College, Sylhet during the period from 1st January 2016 to 31st December 2016.Fiftypatients with cirrhosis of liver fulfilling the inclusion criteria were enrolled as group-A and 50 age-sex matched healthy adults were selected as the control group (group-B). Result: Fasting serum total cholesterol was estimated. Severity of liver Cirrhosis was categorized according to Child-Pugh scoring system and increasing severity was categorized as Child Pugh class A, B and C.Serum total cholesterol is decreased in patients with liver cirrhosis. The level of severity of liver damage significantly affects the serum total cholesterol level in cirrhosis; and may be considered as markers of severity of liver damage in cirrhosis. Conclusion: It may be concluded that hypocholesterelemia exists in patients with liver cirrhosis and screening for severity of cirrhosis by serum total cholesterol is important for intervention with appropriate therapy to reduce the severity of the disease. Key words: Liver cirrhosis,Serum total cholesterol , Child-Pugh score.
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Prokofieva, Natalia A., Igor G. Bakulin, Elena G. Nemtsova, Olga Yu Chizhova, Tatiana S. Fil, Anastasiya G. Sushilova, Elena Yu Pavlova, and Maria S. Orlenko. "New coronavirus infection and liver lesions." Russian Family Doctor 27, no. 2 (July 20, 2023): 65–72. http://dx.doi.org/10.17816/rfd404456.

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BACKGROUND: According to published research outcomes, liver dysfunction is one of the predictors of adverse outcome COVID-19. AIM: To study the frequency and severity of liver damage in COVID-19 and suggest therapeutic and prevention approaches to liver damage. MATERIALS AND METHODS: The study included 171 patients with SARS-CoV-2 pneumonia at the age of 2194 (mean age 59.85 14.96). Clinical and biochemical blood tests, coagulogram, blood ammonia test, number linkage test, multislice computed tomography of the chest, and 13C-metacetin breath test. Patients were divided into two groups depending on the volume of lung injury. Statistical processing of the results was performed with the software SPSS 26. RESULTS: The most frequent symptoms were manifestations of intoxication syndrome, respiratory failure, the severity of which correlated with the volume of lung tissue damage according to multislice computed tomography of the chest. In both groups, the activity of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltranspeptidase, and alkaline phosphate increased. However, significant distinctions in the groups were revealed only for gamma-glutamyltranspeptidase and alkaline phosphate levels. The level of C-reactive protein in both groups directly correlated with the level of cytolysis and cholestasis, indicating a significant role of the liver in pathological processes in COVID-19. Conclusion: Hyperammonemia and decreased liver functional reserve of various severity were observed in all patients. CONCLUSIONS: The findings indicate the diagnostic value of the studied parameters for the evaluation of liver damage, as well as the applications of prevention and treatment measures for liver lesions in patients with COVID-19.
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Reshetnyak, V. I., I. V. Maev, T. M. Reshetnyak, S. V. Zhuravel, and V. M. Pisarev. "Liver Diseases and the Hemostasis (Rewiew) Part 1. Non-Cholestatic Diseases of the Liver and Hemostasis." General Reanimatology 15, no. 5 (November 9, 2019): 74–87. http://dx.doi.org/10.15360/1813-9779-2019-5-74-87.

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In liver diseases, most commonly in the terminal stage of liver failure, a variety of hemostatic defects affecting almost all parts of the blood coagulation system are developing. This leads to diminishing the capabilities of patients with liver diseases to correctly maintain the hemostatic balance.The severity of hemostatic disorders depends on the nosological form and degree of a liver damage. Depending on the imbalance of the hemostasis system and accumulated clinical/laboratory data, patients with liver diseases can be subdivided into three groups as exhibiting: 1. non-cholestatic liver damage; 2. cholestatic liver damage and 3. liver damage of vascular origin.The first part of the review discusses multiple alterations in the hemostasis system in patients with noncholestatic liver diseases, which are commonly accompanied by hypocoagulation.
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Neuman, Manuela G., and Lawrence B. Cohen. "Inflammation and Liver Cell Death in Patients with Hepatitis C Viral Infection." Current Issues in Molecular Biology 43, no. 3 (November 16, 2021): 2022–35. http://dx.doi.org/10.3390/cimb43030139.

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Hepatitis C virus (HCV)-induced liver disease contributes to chronic hepatitis. The immune factors identified in HCV include changes in the innate and adaptive immune system. The inflammatory mediators, known as “inflammasome”, are a consequence of the metabolic products of cells and commensal or pathogenic bacteria and viruses. The only effective strategy to prevent disease progression is eradication of the viral infection. Immune cells play a pivotal role during liver inflammation, triggering fibrogenesis. The present paper discusses the potential role of markers in cell death and the inflammatory cascade leading to the severity of liver damage. We aim to present the clinical parameters and laboratory data in a cohort of 88 HCV-infected non-cirrhotic and 25 HCV cirrhotic patients, to determine the characteristic light microscopic (LM) and transmission electron microscopic (TEM) changes in their liver biopsies and to present the link between the severity of liver damage and the serum levels of cytokines and caspases. A matched HCV non-infected cohort was used for the comparison of serum inflammatory markers. We compared the inflammation in HCV individuals with a control group of 280 healthy individuals. We correlated the changes in inflammatory markers in different stages of the disease and the histology. We concluded that the serum levels of cytokine, chemokine, and cleaved caspase markers reveal the inflammatory status in HCV. Based upon the information provided by the changes in biomarkers the clinician can monitor the severity of HCV-induced liver damage. New oral well-tolerated treatment regimens for chronic hepatitis C patients can achieve cure rates of over 90%. Therefore, using the noninvasive biomarkers to monitor the evolution of the liver damage is an effective personalized medicine procedure to establish the severity of liver injury and its repair.
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Dissertations / Theses on the topic "Severity of liver damage"

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Habib, Shahid, Khalid Khan, Chiu-Hsieh Hsu, Edward Meister, Abbas Rana, and Thomas Boyer. "Differential Simultaneous Liver and Kidney Transplant Benefit Based on Severity of Liver Damage at the Time of Transplantation." ELMER PRESS INC, 2017. http://hdl.handle.net/10150/625529.

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Background: We evaluated the concept of whether liver failure patients with a superimposed kidney injury receiving a simultaneous liver and kidney transplant (SLKT) have similar outcomes compared to patients with liver failure without a kidney injury receiving a liver transplantation (LT) alone. Methods: Using data from the United Network of Organ Sharing (UNOS) database, patients were divided into five groups based on pre-transplant model for end-stage liver disease (MELD) scores and categorized as not having (serum creatinine (sCr) <= 1.5 mg/dL) or having (sCr > 1.5 mg/dL) renal dysfunction. Of 30,958 patients undergoing LT, 14,679 (47.5%) had renal dysfunction, and of those, 5,084 (16.4%) had dialysis. Results: Survival in those (liver failure with renal dysfunction) receiving SLKT was significantly worse (P < 0.001) as compared to those with sCr < 1.5 mg/dL (liver failure only). The highest mortality rate observed was 21% in the 36+ MELD group with renal dysfunction with or without SLKT. In high MELD recipients (MELD > 30) with renal dysfunction, presence of renal dysfunction affects the outcome and SLKT does not improve survival. In low MELD recipients (16 - 20), presence of renal dysfunction at the time of transplantation does affect post-transplant survival, but survival is improved with SLKT. Conclusions: SLKT improved 1-year survival only in low MELD (16 - 20) recipients but not in other groups. Performance of SLKT should be limited to patients where a benefit in survival and post-transplant outcomes can be demonstrated.
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Zambon, Azevedo Vittoria. "Mise au point d’un nouvel outil diagnostique de l’obésité sarcopénique : relations avec la dysfonction du tissu adipeux, l’insulinorésistance et la sévérité de l’atteinte hépatique." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS170.pdf.

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L'obésité sarcopénique (OS) est une condition caractérisée par la coexistence de l'obésité et de la sarcopénie, c'est-à-dire une réduction de la masse et de la fonction musculaires. Diagnostiquer l'OS est très complexe en raison de l'absence de critères diagnostiques universellement acceptés, ce qui entraîne des diagnostics imprécis et une estimation hautement variable de sa prévalence. Face à ces limitations, l'objectif de cette thèse était de développer un outil de diagnostic empirique pour l'OS aidé d'intelligence artificielle, basé sur l'analyse de la composition corporelle. Nous avons élaboré l'AIM-SO score dans une population de sujets en surpoids/obésité puis nous l'avons testé dans deux autres populations, l'une de patients avec obésité sévère subissant une chirurgie bariatrique, l'autre dans la population générale de l'UK Biobank. Une étude longitudinale a également été menée, avec un suivi à un an chez les sujets ayant subi une chirurgie bariatrique. Nous avons étudié les corrélations cliniques, en particulier cardiométaboliques et hépatiques, notamment histologiques per-opératoires, dans la cohorte bariatrique. La prévalence d'OS a été très proche entre ces trois cohortes. L'OS diagnostiquée par l'AIM-SO score était associée à de multiples comorbidités cardiométaboliques, ainsi qu'à une forme plus sévère d'atteinte inflammatoire et fibrosante du foie. Malgré la perte de poids, le bénéfice métabolique (rémission des comorbidités) après chirurgie bariatrique était moindre chez les patients ayant une OS. Des analyses préliminaires de la cohorte UK Biobank ont montré une association significative entre l'OS diagnostiquée par l'AIM-SO score et des paramètres de fonctionnalité musculaire, en particulier la force musculaire. Nous proposons ce nouvel outil diagnostique pour standardiser le diagnostic d'OS et identifier des patients en situation d'obésité avec sarcopénie dont le phénotype cardiométabolique et hépatique est plus sévère. Le diagnostic d'OS pourrait également renseigner le bénéfice attendu des différentes interventions à visée de réduction pondérale participant ainsi à une prise en charge médicale personnalisée
Sarcopenic obesity (SO) is a condition characterized by the coexistence of obesity and sarcopenia, the latter defined as a reduction in muscle mass and function. Diagnosing SO is highly complex due to the lack of universally accepted diagnostic criteria, leading to imprecise diagnoses and highly variable prevalence estimates. Given this scenario, this thesis aimed to develop an empirical diagnostic tool for SO using artificial intelligence, based on the analysis of body composition. We developed the AIM-SO score in a population of patients with overweight/obesity and tested it in two other populations: patients with severe obesity undergoing bariatric surgery (BS) and the general population of the UK Biobank. A longitudinal study with a one-year follow-up was conducted in subjects who underwent BS. We examined clinical correlations, particularly cardiometabolic and hepatic, including perioperative histological findings in the bariatric cohort. The prevalence of SO was similar across these three cohorts. SO diagnosed by the AIM-SO score was associated with multiple cardiometabolic comorbidities and more severe inflammatory and fibrosing liver damage. Despite weight loss, the metabolic benefit (remission of comorbidities) after BS was lower in patients with SO. Preliminary analyses of the UK Biobank cohort showed a significant association between SO diagnosed by the AIM-SO score and parameters of muscular functionality, particularly muscle strength. We propose this new diagnostic tool to standardize the SO diagnosis and identify patients with obesity and sarcopenia who exhibit more severe cardiometabolic and hepatic phenotype. Diagnosing SO could also inform the expected benefit of various weight loss interventions, thus contributing to personalized medical management
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Fisher, D. R. "Studies on residual damage in irradiated liver." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355903.

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Nowak, Urszula. "Rheumatoid factor production in response to liver damage." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84065.

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Many liver diseases such as Alcoholic Liver Disease and Hepatitis C are associated with the production of autoantibodies. One of these autoantibodies is Rheumatoid Factor (RF), which binds to IgG and can aid in host defense. Since little is known about the role of RF in liver disease, we characterized the production of this autoantibody in three murine models of liver damage using alcohol, anti-Fas antibodies and carbon tetrachloride. RF was induced in response to chronic alcohol consumption as well as intraperitoneal injection of anti-Fas antibodies. RF was not produced in response to treatment with carbon tetrachloride for four weeks. Concurrent treatment with an E. coli glycolipoprotein which induces RF protected against liver damage as measured by a decrease in liver enzymes. Importantly, RF induced by this glycolipoprotein did not contribute to damage in the liver, suggesting that in the context of liver damage RF is not necessarily pathological.
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Miyachi, Yosuke. "Causes of liver steatosis influence the severity of ischemia reperfusion injury and survival after liver transplantation in rats." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263516.

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Müller, Hans Christian. "Alternative strategies to reduce liver abscess incidence and severity in feedlot cattle." Thesis, Kansas State University, 2017. http://hdl.handle.net/2097/38157.

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Master of Science
Department of Animal Sciences and Industry
James S. Drouillard
Since the 1960’s liver abscess incidence and severity have been identified as a problem associated with feeding high concentrate finishing rations to feedlot cattle. Liver abscesses lead to decreased feedlot performance and decreased carcass value. Tylosin phosphate is a macrolide antibiotic commonly used by feedlots throughout the United States and has been shown to successfully control liver abscesses. In 2013, the FDA issued Guidance for Industry #213, which encourages reduced usage of medically important classes of antibiotics, such as macrolides, in animal feed. This will be achieved by implementing veterinary oversight of these drugs via Veterinary Feed Directives (VFD). Thus, it is of importance to find alternative strategies to reduce usage of tylosin in finishing rations to control liver abscesses. One strategy that has been suggested is increasing dietary roughage concentration. However, this isn’t a viable option as increasing dietary roughage concentration not only leads to a decline in feedlot performance, hot carcass weight, and dressing percentage, but also has an environmental impact. Available research has also indicated that increasing dietary roughage has no impact on liver abscess incidence or severity. Our research objective was therefore to identify alternative strategies to reduce liver abscess incidence. Our first trial evaluated the impact of antioxidants on liver abscess incidence and severity. Treatments consisted of a control treatment (basal diet containing 200 IU/d α-tocopherol acetate), and an antioxidant treatment (basal diet containing 2000 IU/d α-tocopherol acetate and 500 mg/d crystalline ascorbate). Treatments were randomly assigned to 390 crossbred heifers. No differences in feedlot performance were detected; however, there was a tendency for improved feed intake (P = 0.075) and feed efficiency (P = 0.066) for heifers that received the antioxidant treatment. An increased number of yield grade 3 carcasses (P = 0.03) and fewer yield grade 1 carcasses (P < 0.01) was observed in the antioxidant treatment group. No differences were detected between treatments for other carcass characteristics or liver abscess incidence and severity. Another trial evaluated intermittent tylosin feeding and its impact on liver abscess incidence and antimicrobial resistant Enterococcus spp. when compared to continuous tylosin feeding. One of 3 treatments were randomly assigned to 312 crossbred steers: negative control (no tylosin fed throughout the feeding period); positive control (tylosin fed throughout the feeding period); or intermittent treatment (tylosin fed intermittently throughout the feeding period: 1week on, 2 weeks off). Fecal samples were collected on day 0, 20, and 118 to characterize antimicrobial resistant Enterococcus spp. By design, the intermittent treatment consumed 60% less tylosin than the positive control group. No differences were detected between treatments for feedlot performance. Liver abscess incidence was greatest for the negative control, and least for the positive control and intermittent treatments, with no difference being detected between the latter two treatments (P = 0.716). Antimicrobial resistance was unaffected by treatment, but was affected by sampling time. We concluded that supplementing antioxidants is not a viable option to reduce liver abscess incidence and severity, and that tylosin usage can be decreased without adversely affecting performance or liver abscess incidence.
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Haydon, Geoffrey H. "The severity and activity of liver disease in chronic hepatitis C infection." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/28213.

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The aims were twofold. Firstly, to assess the clinical significance of staging investigations; in particular the significance of molecular virological investigations in terms of disease diagnosis and prognosis. The role of non-invasive investigations in staging the disease process was also considered. Secondly, the impact of chronic hepatitis C infection was assessed in two populations; patients diagnosed as having hepatocellular carcinoma and those immunocompromised chronic HIV infection. In the Scottish population studied, both serum and intrahepatic virus levels were not determined by host factors (age of patient, mode or duration of infection) or by virus factors (HCV genotype). Likewise, there was no correlation between serum and liver HCV RNA levels demonstrated; however, those data did demonstrate that repetitive negative RT-PCR for HCV RNA in serum did not indicate absence of HCV from the liver. Pilot studies of the two non-invasive investigations in this population showed both to be reliable in predicting the presence of hepatic cirrhosis in patients infected with HCV. Amongst the intravenous drug abusers with chronic HIV infection, HCV did not influence either the clinical progression of HIV disease to AIDS and it was not associated with a more rapid immunological decline. Chronic HCV infection was identified as a major risk factor for the development of hepatocellular carcinoma. Molecular virological staging investigations should be interpreted with caution in chronic HCV infection; their most significant role is likely to be the initiation and monitoring of therapy rather than the inference of disease prognosis. Non-invasive investigations of hepatic cirrhosis are likely to be useful tests when a liver biopsy is contraindicated, although they should be first validated in larger, well described populations.
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Kistler, Kristin David. "Nonalcoholic fatty liver disease quality of life, exercise intensity and histological severity /." Diss., [La Jolla] : [San Diego] : University of California, San Diego ; San Diego State University, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3359523.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2009.
Title from first page of PDF file (viewed July 21, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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Висоцький, Ігор Юрійович, Игорь Юрьевич Высоцкий, Ihor Yuriiovych Vysotskyi, Алла Анатоліївна Качанова, Алла Анатольевна Качанова, Alla Anatoliivna Kachanova, V. I. Vysotsky, Ya V. Serduk, and K. R. Denisova. "Chronopharmacological peculiaries of antioxidants action in toxic liver damage." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/41261.

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Holland, Michael J. "Measuring Disease Damage and its Severity in Childhood-Onset Systemic Lupus Erythematosus." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1527606864223975.

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Books on the topic "Severity of liver damage"

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Parker, Philip M., and James N. Parker. Liver damage: A medical dictionary, bibliography, and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

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2

Lee, Kirsten. Young alcoholics: The risk of intellectual impairment, cerebral atrophy, cerebral thrombosis and liver damage. København, Århus, Odense: Fadl's Forlag, 1987.

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Mohamed Hatem Fathi El-Saied Wali. Natural history, factors affecting severity and progression rate of hepatitis c virus (HCV) infection in liver transplanted and non-transplanted patients. Birmingham: University of Birmingham, 2002.

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Maxwell, Paul Ross. Human glutathione-S-transferases: Examination of the iso-enzymes alpha and pi as biomarkers of kidney and liver damage. [S.l: The Author], 2003.

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1925-, Dianzani M. U., Gentilini Paolo, and Università di Firenze, eds. Chronic liver damage: Proceedings of the Annual Meeting of the Italian National Programme on Liver Cirrhosis, San Miniato, Italy, 11-13 January 1990, with the sponsorship of the University of Florence. Amsterdam: Excerpta Medica, 1990.

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McPherson, Andrew. Reversal of Liver Fibrosis: Preventing Further Liver Damage. Independently Published, 2019.

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Chronic Liver Damage (International congress series). Elsevier, 1990.

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FM, Prof Dr Bilqees, Samreen Mirza, and Prof Dr Khatoon N. PARAMPHISTOMUM CERVI INFECTION AND LIVER TISSUE DAMAGE IN BUFFALOES: Trematode infection and liver tissue damage in Buffaloes. VDM Verlag Dr. Müller, 2011.

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Levy, Barry S. Liver Disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190662677.003.0030.

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This chapter describes occupational and environmental liver disorders. It describes the types of liver function and types of liver damage, and how these functions and this damage can be assessed. Workers in healthcare and solid waste management are at increased risk hepatitis B virus and hepatitis C virus infections. Occupational exposure to swine is associated with hepatitis E virus infection. More than 100 industrial chemicals can be acutely hepatotoxic in experimental animals or humans. Metabolic reactions may affect the hepatotoxicity of chemicals. Occupational exposure to organic solvents can cause toxic hepatitis. Occupational exposure to vinyl chloride monomer has been causally associated with toxicant-associated fatty liver disease as well as a form of non-cirrhotic portal hypertension. Several agents can cause cancer of the liver or bile ducts. Vinyl chloride monomer is causally associated with angiosacoma of the liver. Arsenic causes liver cancer. Dietary exposure to aflatoxins can cause hepatoceulluar carcinoma.
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van Aerts, René M. M., Tom J. G. Gevers, and Joost P. H. Drenth. Management of cystic liver disease. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0311_update_001.

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In a subset of autosomal dominant polycystic kidney disease patients, hepatic cysts dominate the clinical picture. These patients may develop polycystic liver disease, and enlargement of the liver leads to compression of adjacent abdominal and thoracic organs. The main risk factors for growth of liver cysts are female sex, exogenous oestrogen use, multiple pregnancies, and severity of renal disease. Treatment is only indicated in those with symptoms, and choice of treatment depends on total liver volume, size, and location of the liver cysts. Current radiological and surgical therapies include aspiration-sclerotherapy, fenestration, segmental hepatic resection, and liver transplantation. They all are palliative in nature and are partially effective and have non-negligible morbidity and mortality. Somatostatin analogues are still in development for polycystic liver disease.
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Book chapters on the topic "Severity of liver damage"

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Larrosa-Haro, Alfredo, Erika F. Hurtado-López, Rocío Macías-Rosales, and Edgar M. Vásquez-Garibay. "Liver Damage Severity Evaluated by Liver Function Tests and the Nutritional Status Estimated by Anthropometric Indicators." In Handbook of Anthropometry, 2201–12. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-1788-1_135.

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Rizzo, Maria, and Patrizia Gasparini. "Forest Health." In Springer Tracts in Civil Engineering, 447–68. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98678-0_10.

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AbstractForests mainly consist of long-lived trees or shrub species and are exposed to natural or human disturbances of different severities. They are essential components of the natural development of forest ecosystems, since by triggering natural selection and ecological succession processes, they can achieve the best status in terms of species composition and structure. Nevertheless, extreme events can cause serious economic or naturalistic losses and, in some cases, endanger specific forest ecosystems. Disturbance events that damage forests vary and include pests and diseases, fires, pollution, climate changes, overexploitation or inadequate silvicultural practices, excessive grazing and browsing, to name just a few. Health monitoring of forests is a necessary condition to provide useful information for the conservation of forest resources, as well as to support forest management practices aimed at increasing the resilience of forests and their adaptation capacity. Through ground surveys, the Italian national forest inventory INFC has classified the health condition of Italian forests and produced the estimates presented in the chapter. These concern the distribution of the Forest area by pathologies and damage presence, severity and cause. Estimates of the Forest area affected by defoliation, divided by defoliation class and localization of defoliation, are also presented.
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Castera, Laurent. "Assessment of Liver Disease Severity." In Hepatitis C: Care and Treatment, 1–20. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67762-6_1.

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Godart, Bruno, Mario de Rooij, and Jonathan G. M. Wood. "Severity Investigation." In Guide to Diagnosis and Appraisal of AAR Damage to Concrete in Structures, 65–78. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6567-2_5.

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Soranno, Thomas M., and Lester G. Sultatos. "Alcohol and Liver Damage." In Liver Pathology and Alcohol, 425–40. Totowa, NJ: Humana Press, 1991. http://dx.doi.org/10.1007/978-1-4612-0421-3_16.

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Shuster, Louis. "Morphine and Liver Damage." In Liver Pathology and Alcohol, 593–616. Totowa, NJ: Humana Press, 1991. http://dx.doi.org/10.1007/978-1-4612-0421-3_23.

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Dancygier, Henryk, and Peter Schirmacher. "Radiation-Induced Liver Damage." In Clinical Hepatology, 203–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-93842-2_22.

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Kuntz, Erwin, and Hans-Dieter Kuntz. "Alcohol-induced liver damage." In Hepatology, 469–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04680-7_28.

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Kuntz, Erwin, and Hans-Dieter Kuntz. "Drug-induced liver damage." In Hepatology, 489–506. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04680-7_29.

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Vuille-Lessard, Élise, Ahmed Y. Elmahdy, and Annalisa Berzigotti. "Assessing Disease Severity and Prognosis." In Elastography of the Liver and Beyond, 173–90. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-74132-7_12.

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Conference papers on the topic "Severity of liver damage"

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Kasetkasem, Teerasit, Surasak Choedpasuporn, and Pudtraporn Napang. "Rice Paddy Flood Damage Severity Assessment Using Drone Images." In IGARSS 2024 - 2024 IEEE International Geoscience and Remote Sensing Symposium, 10250–53. IEEE, 2024. http://dx.doi.org/10.1109/igarss53475.2024.10641579.

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Kurnikova, Irina, Shirin Gulova, Guzal Akhmadullina, Natalia Danilina, and Ikram Mokhammed. "Methods of computer simulation in the development of technology for the functional assessment of the state of the liver in patients." In 14th International Conference on Applied Human Factors and Ergonomics (AHFE 2023). AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1003456.

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Most of the diseases associated with carbohydrate and fat metabolism disorders (type 2 diabetes mellitus, obesity, metabolic syndrome) lead to changes in the structure and function of liver cells, and the formed liver dysfunction negatively affects the further progression of the disease. The process of liver damage develops with varying intensity and does not immediately lead to irreversible consequences; therefore, dysfunction should be detected as early as possible, and the data obtained should be used to assess the current state and predict their reversibility.Study purpose. To create a quantitative assessment method that allows to assess the current functional state of the liver and to determine the reversibility of existing functional disorders and the severity of structural changes, to assess the prognosis of the course of the disease and the effectiveness of restorative measures.Instruments and Data Collection Procedure. Examination of patients, in addition to conventional methods, included an assessment of the absorptive-excretory function of the liver and biliary tract patency using a scintillation gamma camera (Siemens Symbia T16) with subsequent processing on the SUPER-SEGAMS computer system (Hungary). Freshly prepared Bromesida, 99mТс was administered intravenously at the rate of 1.1 MBq per kg of the patient's body weight, with a normal content of bilirubin in blood. Series of scintigrams allow to assess the passage of the drug visually through the blood-liver-ducts-intestine system, to characterize the anatomical features and organic changes in the biliary system. Quantitative analysis of the "activity-time" curves obtained from the areas of interest (the right lobe of the liver - 2 zones, the left lobe of the liver, the common bile duct, the intestinal area, the heart area) makes it possible to study the absorptive-excretory function of the liver.Results. By the method of mathematical modeling, a formula was obtained - the index of the functional activity of hepatocytes:IFAH= (-1,1564 + 0,0653 × BMI - 0,0144 × Tmax) × 100,where:IFAH - index of functional activity of hepatocytes (liver cells);BMI - body mass index (kg/m2)Tmax - indicator of the absorption function of the liver (min) - the time to reach the maximum accumulation of the radiopharmaceutical in the liver. It is an indicator of the function of polygonal liver cells (normal = 8-12 min).Functional activity of hepatocytes: from 0 to 9.9 - normal functional activity of hepatocytes; from 10 to 19.9 - the risk of developing functional disorders; from 20 to 29.9 - reversible dysfunction of hepatocytes (steatosis); more than 30 - irreversible (organic) liver dysfunction (steatohepatitis). With negative IFAH values - the influence of extrahepatic factors, such as diseases that accelerate metabolism at the cellular level (thyrotoxicosis), taking drugs in violation of the prescriptions before these studies.The originality and novelty of the technique are confirmed by the patent – “A method for diagnosing fatty hepatosis” (patent RU 2 578 080 C2 dated February 19, 2016).The method was tested in clinical practice and the data obtained confirmed the high diagnostic accuracy (95%) of the proposed method for calculating the index of IFAH.Conclusion: the discussed method allows doctors to evaluate not only the current functional state of the liver, but also to determine the reversibility of existing functional disorders and the severity of structural changes; also could be used to evaluate the prognosis of the course of the disease and the effectiveness of restorative measures. It is characterized by relative ease of implementation. Only one parameter — Tmax is required, after which the study can be completed.
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Altunlu, A. Can, Peter van der Hoogt, and Andre´ de Boer. "Life Assessment by Fracture Mechanics Analysis and Damage Monitoring Technique on Combustion Liners." In ASME 2011 Turbo Expo: Turbine Technical Conference and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/gt2011-46107.

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A methodology has been developed and tested including a multi-disciplinary framework towards integrated analysis of gas turbine combustors. The sub-elements consist of combustion dynamics, stress and modal analysis, fracture mechanics and structural health monitoring have been interlinked indicating the damage evaluation to life assessment. The interaction between the interrelated combustion driven flame dynamics, acoustic pressure fluctuations and liner wall vibration has been investigated in the laboratory combustor test system. During the operation, the combustion, acoustics and wall vibrations have been coupled together. The dynamic combustion process generates high amplitude pressure oscillations resulting in vibration of the liner structure at about constant elevated temperature in base load operation. The thermo-acoustic instabilities have a significant destructive impact on the life of the liner material due to high cyclic vibration levels at high temperature. A structural health monitoring (SHM) method has been established to identify the damage, detect the flaw existence and determine the location, severity and progress of the damage for the combustion liners. Vibration-based and acoustic emission (AE) techniques have been applied in the test system to assess the structural behavior. The applicability of the technique has been tested by examining the dynamic modal parameters of the structure. The method enables a reliable assessment on the liner specimen at elevated temperatures by means of non-destructive evaluation under continuous operation of the combustor. The combustion liner specimen material has been assessed by calculating the near-tip fields at the crack tip by finite element based stress and fracture mechanics analysis. An algorithm based on J-Integral has been utilized to analyze the crack growth behavior under various loading conditions considering both linear and non-linear elastic fracture mechanics concepts. The location and the direction of the cracking on the liner specimen have been predicted. The presented work interrelates the different mechanisms in gas turbine combustors and the applicability of the concepts has been verified and validated in the test systems.
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Kvitrud, Arne. "Collisions Between Platforms and Ships in Norway in the Period 2001-2010." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-49897.

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Since 1982, 115 collisions have been reported on the Norwegian Continental Shelf, with varying degree of severity. In the period 2001–2010 there have been 26 reported collisions. None of the collisions has caused loss of lives or personnel injuries. The economic consequences however have been significant, especially one collision in 2009. This paper will give statistical summaries of the events, and compare the development of events with previous periods. The focus will be on the six most severe cases, describing each case, the damage and emphasise the most common causes of these events.
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Yan, Jihong, and Pengxiang Wang. "Blade Material Fatigue Assessment Using Elman Neural Networks." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43311.

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Material degradation evaluation and life prediction of major components such as blades, rotors, valves of steam turbines not only guarantees reliable, efficient and continuous operation of electric plants, but also offers the promise of substantially reducing the cost of repair and replacement of defective parts, and may even result in saving lives. In this paper, a recurrent neural network based strategy was developed for material degradation assessment and fatigue damage propagation prediction. Two Elman Neural Networks were developed for fatigue severity assessment and trend prediction correspondingly. The performance of the proposed prognostic methodology was evaluated by using blade material fatigue data collected from a material testing system. The prognostic method is found to be a reliable and robust material fatigue predictor.
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Wu, Shuming, Xuefeng Chen, Pete Russhard, Shibin Wang, Zhi Zhai, and Zhibin Zhao. "Foreign Object Damage Diagnosis of Aero-Engine Compressor Based on Damping Averaging Built-in Matrix Method." In ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-75798.

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Blade Tip Timing (BTT) methods are being implemented that have led to a non-intrusive technique being deployed in certain sectors of Industry. Data sets produced during the development cycle are now providing upfront information that is being used to develop monitoring capability supporting in-service health monitoring. Recent years have witnessed a growing interest in blade health monitoring and its potential to detect the occurrence of both transient and permanent foreign object damage (FOD) and estimate the severity of damage to blades. FOD damage detection is beneficial to both the fan and first stage compressors and the ability to detect it leads to a reduction in the number of inspection that recurrently scheduled. The expected behaviour under transient FOD condition is a ‘ringing’ signal which is a damped exponential signal. The lack of real FOD data collected requires that a signal is simulated and used to develop and validate detection systems. Blade tip timing is an effective implementation of non-intrusive technology by circumferentially arranged sensors to obtain the time of arrival (TOA) of blades. However, due to the high degree of undersampling inherent in the data the detection of short-lived events poses a problem. In this paper the use of a method called ‘Damping Averaging Built-in Matrix’ (DABM), which use the combination of several revolutions data and OPR (once per revolution) data to enhance the sample rate while eliminating the damping effect. After solving the matrix we are able to obtain the frequency and damping of the blade when transient FOD occurs. The FEM (finite element model) of the blade is also built to infer the stress of blade at different levels of FOD. The method is applied to both the simulated data and experimental data to verify its effectiveness. By developing this method further we can provide a capability that could reduce the operation and maintenance cost and increase the security of the engine whilst in operation.
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Pong Poo, Ching, Leila Kamalian, Zaili Yang, and Yui-yip Lau. "Climate Threats and Resilience Assessment of Road and Railway Networks: Scenario Analysis for 2025, 2030, 2050." In 6th International Conference on Human Systems Engineering and Design Future Trends and Applications (IHSED 2024). AHFE International, 2024. http://dx.doi.org/10.54941/ahfe1005560.

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Road and railway networks are significantly impacted by climate change, facing various climate extremes on different scales (de Miranda Pinto et al., 2018, Hooper and Chapman, 2012, Nemry and Demirel, 2012)Forecasting the future impacts on these essential transport and logistics links, vital for human lives, goes beyond likelihood and risk severity. Resilience, a key factor, is evaluated uniquely in this study. We employ Bayesian network analysis to assess the strength of road and railway systems in relation to various climate-induced threats under changing climatic conditions. (Zhou et al., 2017). This research model explicitly impacts road networks for 2025, 2030, and 2050 by analysing the likelihood of occurrences, the extent of damage, and overall resilience.Understanding the urgency of these impacts is essential for proactive planning and policymaking. This study, with its comprehensive framework that integrates various factors influencing the resilience of transportation networks, is a proactive step. It highlights the importance of incorporating resilience assessments into infrastructure planning and management, which will help mitigate potential disruptions and ensure the continued functionality and reliability of transport networks in the face of climate change.
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Santiago, Mayhara Rosany da Silva, Ana Caroline Paiva Simeão, Heloisy Maria Nunes Galvão, Miriam Carvalho Soares, Igor de Oliveira, Pedro Nogueira Fontana, and Renata Amaral Andrade. "Atypical case of Wilson’s disease presenting with unusual neuroimage features." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.351.

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Introduction: Wilson’s disease (WD) is a rare autosomal recessive disorder resulting in hepatic and neurological symptoms. Uncommon presentations are prone to diagnostic and treatment delay. Objectives: Describe an atypical case of WD and improve clinicians awareness. Case report: A 19 years-old male presented to us with seizures and upper limb tremor in the past three years, evolving to torsion-like movements in limbs and trunk. He was unable to open his eyes and had severe dysphagia. There was no consanguinity, perinatal complications or neurodevelopmental delay. Examination revealed generalized dystonia, blepharospasm, retrocollis, dysarthria, trismus, right hemiparesis and marked muscle wasting; there was a gray halo around both irises. The patient was bedridden and severely dependent. Magnetic resonance imaging (MRI) showed T2/FLAIR (T2-weightedFluid-Attenuated Inversion Recovery) hyperintense lesions in the left hemisphere, basal ganglia and cerebellar peduncles. Laboratory workup revealed low ceruloplasmin levels (< 8 mg/dL; range: 16–45), serum copper of 44.2 mcg/dL (range: 70–140). A diffuse increased echogenicity was described in liver ultrasound. The patient had no clinical or laboratorial evidence of liver damage. Due to presumed Kayser-Fleisher rings, movement disorders and MRI findings, WD was suspected. Genetic test revealed two variants in the ATB7B gene, probably a compound heterozygosity. Having a final Leipzig score of 7, WD diagnosis was established. Conclusion: WD may present with cortico-subcortical involvement. Hepatic subclinical involvement may delay WD diagnosis. It is important to have a high index of suspicion for WD in any movement disorder in young people. In order to prevent treatment delay and severe neurologic sequel, neurologists should be aware about atypical clinical and radiological presentations of this treatable disease.
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Torres, C. R., and A. P. Dean. "Quantifying the Severity of Mechanical Damage." In 2004 International Pipeline Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ipc2004-0186.

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Current industry standards used for incorporating in-line inspection (ILI) data in the quantification of mechanical damage defects are relatively narrow in scope. The primary reason for this is the industry standards evolved around ILI tool limitations that existed several years ago. In recent years, there have been new technological developments in areas such as ILI tool capacity, new applications of mathematical principles, and increases in the types of mechanical damage characteristics identified with ILI tools. It is the opinion of this paper’s authors that these new developments have created opportunities for better integrity decisions based on sound engineering principles, eventually leading to much broader industry standards as well as economic benefits for the pipeline industry. The primary purpose of this paper is to describe the results of a research and development project recently completed by Tuboscope Pipeline Services and the Battelle Institute, the objective of which was to develop an algorithm to quantify the severity of mechanical damage defects.
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Cikach, Frank, Ibrahim Hanouneh, Kelly Paschke, David Grove, Alquam Mashir, Nizar Zein, Raed A. Dweik, and Daniel Laskowski. "Breath Analysis Identifies The Severity Of Liver Disease." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3781.

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Reports on the topic "Severity of liver damage"

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Chell and Crouch. HIX1IYS Nonlinear Harmonic Based Mechanical Damage Severity for Delayed Failures in Pipelines. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), January 2008. http://dx.doi.org/10.55274/r0011186.

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The objectives of the current work are to (1) provide an assessment of the capabilities of the nonlinear harmonic (NLH) method to detect gouged dents in pressurized pipelines; (2) rank the severity of the detected defects against delayed failure; (3) provide information related to the remaining lives of detected defects when fatigue damage from cyclic pressure changes is the time-dependent mechanism controlling delayed failure; and (4) transfer the developed NLHbased defect severity criteria to an inline inspection vendor, Tuboscope Pipeline Services. An ancillary objective is to assess the capability of NLH probes to detect strain anomalies produced by crack-like flaws in the outside surfaces of pressurized pipes. In this project, the assessment of the capabilities of NLH to detect and rank the severity of defects is based on the analysis of results obtained from NLH measurements performed over the inside surfaces of pressurized pipe sections containing gouged dents subjected to cyclic pressure changes (fatigue loading) that eventually resulted in failure (leakage) at defects, and NLH scans of statically pressurized pipes containing crack-like machined notches.
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Ott, Lee W., Frank Witzmann, Camilla A. Mauzy, Claude C. Grigsby, Deirdre A. Mahle, and John J. Schlager. Quantifying Biomarkers of Liver Damage Using Shotgun Proteomics. Fort Belvoir, VA: Defense Technical Information Center, August 2006. http://dx.doi.org/10.21236/ada498948.

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Leis, Brian, Xian-Kui Zhu, and Tom McGaughy. PR-185-133739-R01 Quantifying Re-Rounding in Pipeline Damage Severity Models. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), April 2018. http://dx.doi.org/10.55274/r0011479.

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The objective of this work was to quantify re-rounding effects on mechanically damaged pipelines. This was done to determine if curvature suffices to identify where the effects of re-rounding are localized. It also was done to establish a framework that could be calibrated through subsequent analysis as an input to guidelines for damage severity assessment. Recognizing the expanding role of ILI and related in-the-ditch evaluation tools to help size and characterize damage, brief consideration was also given to ongoing work within the PRCI Nondestructive Evaluation (NDE) Program. This was done regarding the use of such technologies to assess metallurgical changes in the damaged zone and their integration into model development and sensitivity analysis. Key conclusions for the analysis completed for this project and its validation by comparison to full-scale data include: - Re-rounding can cause significant nonlinear effects in otherwise simple pressure cycling, due in part to localized strain hardening and localized kink formation when it occurs within dents and/or gouges; - Metal-loss due to gouging can be simply idealized without jeopardizing the utility of analysis of the effects of re-rounding, as shown by three validation cases benchmarked against full-scale test-ing; - Re-rounding showed a first-order dependence on pipe geometry and pressure; and - Curvature change appears adequate to quantify re-rounding, but is inadequate to quantify local damage severity in a Level 1 damage screening tool: this also requires consideration of membrane strain (stress) and wall thinning where it is evident. The dependence of re-rounding on pipe geometry and pressure should be broadly quantified, with analyses to trend the role of membrane stress included to build the basis for an ILI-based model to screen damage severity.
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Teitsma, Albert. L52091 Better Understanding of Mechanical Damage in Pipelines. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), January 2004. http://dx.doi.org/10.55274/r0011829.

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This report summarizes work done at the Battelle Memorial Institute, (Nestleroth, 2003) and the Southwest Research Institute (Chell, 2003) on "Better Understanding of Mechanical Damage in Pipelines" for DOT and GTI under the direction of the Gas Technology Institute. Battelle Memorial Institute concentrated on developing MFL technologies for detecting and characterizing mechanical damage defects. Combining axial and circumferential MFL, provides sensitivity to defects of all orientations, accurately determines the width and length of a defect, and more accurately predicts defect depths due to better compensation for geometry generated MFL amplitude changes. High-low magnetization field MFL detects and qualitatively characterizes mechanical defects and provides a quantitative measure of the depth of the initial dent from the reround halo if the pipe has rerounded. Absence of a reround halo would indicate a possibly innocuous defect. Good correlation was found between FEA stresses and strains and the measured NLH results. NLH characterizes mechanical damage qualitatively. Fractographic and metalograhpic analysis after burst tests were used along with engineering judgment and stress calculation to rank the severity of mechanical damage with respect to variation in length width and depth. An empirical formula is proposed for quickly calculating the relative severity of mechanical damage defects. All methods for characterizing mechanical damage, the formula, fractographic and metallographic, MFL, NLH, FEA, and engineering judgment correlated well with each other.
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Dinovitzer. L52048 Evaluation of the Interaction of Mechanical Damage on Welds. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), June 2007. http://dx.doi.org/10.55274/r0010393.

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Failures in transmission pipelines are often the result of mechanical damage. The US DOT has indicated that 20 to 40 percent of the serious pipeline incidents in any given year are related to mechanical damage. This damage is due to third party activities, mishandling during construction, pipeline bedding material consolidation, or ground movement. This project report includes a discussion of the following work: Development of a criteria for weld interaction with restrained rock dents, pipe ovality and wrinkles; Development of a means of considering pressure fluctuation severity in these criteria, and Development of guidance and recommendations on how to consider the effects of soil confinement.
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Francini and Yoosef-Ghodsi. PR-218-063511-R02 A Model for Predicting the Severity of Pipeline Damage Identified by In-Line Inspection. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), August 2009. http://dx.doi.org/10.55274/r0010697.

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The development of the damage severity model will provide a significantly improved technical basis to evaluate potential threats and develop general guidance for the industry. When combined with the results from parallel PRCI projects, this effort will form the basis for delivering a new suite of engineering tools and guidance to the industry on how to evaluate the potential hazards associated with mechanical damage.
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Homberg, Marloes, Robrecht Knapen, Kobe Jans, Sander van Kuijk, Dianne de Korte-de Boer, Bert Joosten, Wolfgang Buhre, Sanne de Boer, Christiaan van der Leij, and Esther Bouman. Post Procedural Pain Following Percutaneous Thermal Liver Tumor Ablation under Procedural Sedation and Analgesia: A Single Center Retrospective Cohort Study. Science Repository, May 2024. http://dx.doi.org/10.31487/j.acr.2024.01.02.sup.

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Background and Objectives: The incidence of post-procedural pain following percutaneous thermal liver ablation under procedural sedation and analgesia (PSA) is yet largely unknown. Only a few small studies investigated tumor and ablation factors on pain, whereas psychological or PSA factors as possible predictors for pain were not investigated. The primary aim of the current study is to measure the prevalence and severity of post-procedural pain based on maximal NRS. Secondary aim of this study is to identify predictors for post procedural pain post liver ablation under PSA. Methods: This single center retrospective cohort study was conducted in a tertiary teaching hospital in the Netherlands from November 2018 until May 2023. It involved adult patients (18 years or older) treated with thermal liver ablation under PSA. Prevalence of pain was based on percentage of patients with post-procedural pain (defined as numeric rating scale (NRS) score ≥4). Results: In total, 170 records of 117 patients were included in the analysis of this study. The prevalence of post- procedural pain after thermal liver ablation was 42.7%. Predictors of post-ablation pain were psychological factors e.g. depression, anxiety disorder or the use of psychopharmacological drugs (β 2.58, 95%CI: 1.44-4.07, p-value<0,001). A background of chronic pain (β 1.23, 95%CI: 0.11-2.36, p-value 0.03), female gender (β 1.09, 95%CI: 0.17-2.01, p-value 0.02) and age (β -0.04 per calendar year, 95%CI: -0.091- -0.006, p-value 0.05) were shown to predict acute ablation pain. Tumor location, distinction between primary and secondary tumors and number of tumors did not predict post-ablation pain. Conclusion: The incidence of post-procedural pain after thermal liver ablation is 42.7%. Predictive factors of post procedural pain after thermal liver ablation under PSA are psychological factors like depression and anxiety as well as the use of psychopharmacological drugs. Tumor characteristics did not predict post-procedural pain after ablation.
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Homberg, Marloes, Robrecht Knapen, Kobe Jans, Sander van Kuijk, Dianne de Korte-de Boer, Bert Joosten, Wolfgang Buhre, Sanne de Boer, Christiaan van der Leij, and Esther Bouman. Post Procedural Pain Following Percutaneous Thermal Liver Tumor Ablation under Procedural Sedation and Analgesia: A Single Center Retrospective Cohort Study. Science Repository, May 2024. http://dx.doi.org/10.31487/j.acr.2024.01.02.

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Background and Objectives: The incidence of post-procedural pain following percutaneous thermal liver ablation under procedural sedation and analgesia (PSA) is yet largely unknown. Only a few small studies investigated tumor and ablation factors on pain, whereas psychological or PSA factors as possible predictors for pain were not investigated. The primary aim of the current study is to measure the prevalence and severity of post-procedural pain based on maximal NRS. Secondary aim of this study is to identify predictors for post procedural pain post liver ablation under PSA. Methods: This single center retrospective cohort study was conducted in a tertiary teaching hospital in the Netherlands from November 2018 until May 2023. It involved adult patients (18 years or older) treated with thermal liver ablation under PSA. Prevalence of pain was based on percentage of patients with post-procedural pain (defined as numeric rating scale (NRS) score ≥4). Results: In total, 170 records of 117 patients were included in the analysis of this study. The prevalence of post- procedural pain after thermal liver ablation was 42.7%. Predictors of post-ablation pain were psychological factors e.g. depression, anxiety disorder or the use of psychopharmacological drugs (β 2.58, 95%CI: 1.44-4.07, p-value<0,001). A background of chronic pain (β 1.23, 95%CI: 0.11-2.36, p-value 0.03), female gender (β 1.09, 95%CI: 0.17-2.01, p-value 0.02) and age (β -0.04 per calendar year, 95%CI: -0.091- -0.006, p-value 0.05) were shown to predict acute ablation pain. Tumor location, distinction between primary and secondary tumors and number of tumors did not predict post-ablation pain. Conclusion: The incidence of post-procedural pain after thermal liver ablation is 42.7%. Predictive factors of post procedural pain after thermal liver ablation under PSA are psychological factors like depression and anxiety as well as the use of psychopharmacological drugs. Tumor characteristics did not predict post-procedural pain after ablation.
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9

Leis and Francini. L51832 Line Pipe Resistance to Outside Force. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), November 1999. http://dx.doi.org/10.55274/r0010143.

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These reports present the results of a project whose objective was the development of a "patch"� to the PRCI ductile flaw growth model (DFGM), so that this successful technology could be extended to include mechanical damage. The ultimate goal is a criterion to assess damage severity based solely on field-measurable inputs and nominal information about the pipeline. It is anticipated that such a criterion will lead to cost-effective, timely action to ensure safety and serviceability of high-pressure transmission pipelines, as continuing use of in-line inspection tools makes it increasingly possible to detect mechanical damage.
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Ogunbire, Abimbola, Panick Kalambay, Hardik Gajera, and Srinivas Pulugurtha. Deep Learning, Machine Learning, or Statistical Models for Weather-related Crash Severity Prediction. Mineta Transportation Institute, December 2023. http://dx.doi.org/10.31979/mti.2023.2320.

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Nearly 5,000 people are killed and more than 418,000 are injured in weather-related traffic incidents each year. Assessments of the effectiveness of statistical models applied to crash severity prediction compared to machine learning (ML) and deep learning techniques (DL) help researchers and practitioners know what models are most effective under specific conditions. Given the class imbalance in crash data, the synthetic minority over-sampling technique for nominal (SMOTE-N) data was employed to generate synthetic samples for the minority class. The ordered logit model (OLM) and the ordered probit model (OPM) were evaluated as statistical models, while random forest (RF) and XGBoost were evaluated as ML models. For DL, multi-layer perceptron (MLP) and TabNet were evaluated. The performance of these models varied across severity levels, with property damage only (PDO) predictions performing the best and severe injury predictions performing the worst. The TabNet model performed best in predicting severe injury and PDO crashes, while RF was the most effective in predicting moderate injury crashes. However, all models struggled with severe injury classification, indicating the potential need for model refinement and exploration of other techniques. Hence, the choice of model depends on the specific application and the relative costs of false negatives and false positives. This conclusion underscores the need for further research in this area to improve the prediction accuracy of severe and moderate injury incidents, ultimately improving available data that can be used to increase road safety.
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