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1

United States. Congress. House. A bill to amend title II of the Social Security Act to provide for treatment of severe spinal cord injury equivalent to the treatment of blindness in determining whether earnings derived from services demonstrate an ability to engage in substantial gainful activity. Washington, D.C: U.S. G.P.O., 1999.

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2

Bryce, Thomas N. Spinal cord injury. New York: Demos Medical, 2010.

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3

Richard, Levi, ed. Spinal cord injury. New York: Oxford University Press, 2010.

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4

E, Selzer Michael, ed. Spinal cord injury. New York, N.Y: Demos Logo, 2008.

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5

N, Bryce Thomas, ed. Spinal cord injury. New York: Demos, 2010.

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6

Spinal injury. 2nd ed. East Norwalk, Conn: Appleton-Century-Crofts, 1986.

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7

Hammell, Karen Whalley. Spinal cord injury rehabilitation. London: Chapman & Hall, 1995.

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8

Galeoto, Giovanni, Anna Berardi, Marco Tofani, and Maria Auxiliadora Marquez, eds. Measuring Spinal Cord Injury. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-68382-5.

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9

Hammell, Karen Whalley. Spinal Cord Injury Rehabilitation. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-4451-1.

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10

C, Field-Fote Edelle, ed. Spinal cord injury rehabilitation. Philadelphia, PA: F. A. Davis, 2009.

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11

Somers, Martha Freeman. Spinal cord injury: Functional rehabilitation. 3rd ed. Boston: Prentice Hall, 2010.

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12

Grundy, David. ABC of spinal cord injury. 2nd ed. London: BMJ Pub. Group, 1993.

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13

National Consensus Conference on Catastrophic Illness and Injury (1989 Atlanta, Ga.). Spinal cord injury: The model. [S.l: s.n.], 1990.

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14

Hooper, Mandy. Sexuality and spinal cord injury. London: Spinal Injuries Association, 1995.

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15

Grundy, David. ABC of spinal cord injury. London: British Medical Journal, 1986.

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16

Kalb, Robert G., and Stephen M. Strittmatter, eds. Neurobiology of Spinal Cord Injury. Totowa, NJ: Humana Press, 2000. http://dx.doi.org/10.1007/978-1-59259-200-5.

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17

Management of spinal cord injury. 2nd ed. Boston: Jones and Bartlett Publishers, 1992.

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18

Spinal cord injury: Functional rehabilitation. Norwalk, Conn: Appleton & Lange, 1992.

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19

G, Kalb Robert, and Strittmatter Stephen M, eds. Neurobiology of spinal cord injury. Totowa, N.J: Humana Press, 2000.

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20

David, Grundy, and Swain Andrew, eds. ABC of spinal cord injury. 4th ed. London: BMJ, 2002.

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21

Spinal cord injury: Functional rehabilitation. 3rd ed. Upper Saddle River, N.J: Pearson Education, 2010.

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22

Cripps, Raymond. Spinal cord injury, Australia, 2006-07. Canberra: Australian Institute of Health and Welfare, 2009.

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23

Ngonyani, Joachim Burchard. Living with spinal cord injury disability. [Dar es Salaam: Peramiho Print. Press, 2008.

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24

Norton, Lynda. Spinal cord injury, Australia, 2007-08. Canberra: Australian Institute of Health and Welfare, 2010.

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25

O'Connor, Peter J. Spinal cord injury, Australia: 2000-01. Canberra: Australian Institute of Health and Welfare, 2003.

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26

Daniel, Savoie, DeCorwin Sophie, Quebec Paraplegic Association, and Canadian Paraplegic Association, eds. Life after a spinal cord injury. [Quebec]: Bibliothéque nationale du Quèbec, 1997.

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27

Dimitrijevic, Milan R. Restorative neurology of spinal cord injury. New York: Oxford University Press, 2012.

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28

N, Ozer Mark, and Schmitt James K, eds. Medical complications of spinal cord injury. Philadelphia, Pa: Hanley & Belfus, 1987.

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29

Rejc, Enrico, Ronaldo M. Ichiyama, and Claudia A. Angeli, eds. Advances in Spinal Cord Epidural Stimulation for Motor and Autonomic Functions Recovery After Severe Spinal Cord Injury. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-391-9.

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30

Dietrich, W. Dalton. Physiologic Modulators of Neural Injury After Brain and Spinal Cord Injury. Edited by David L. Reich, Stephan Mayer, and Suzan Uysal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190280253.003.0001.

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Brain and spinal cord injury are leading causes of death and long-term disability, producing diverse burdens for the affected individuals, their families, and society. Such injuries, including traumatic brain injury, stroke, subarachnoid hemorrhage, and spinal cord injury, have common patterns of neuronal cell vulnerability that are associated with a complex cascade of pathologic processes that trigger the propagation of tissue damage beyond the acute injury. Secondary injury mechanisms, including oxidative stress, edema formation, changes in cerebral blood flow and vessel reactivity, metabolic and blood–brain barrier disruption, and neuroinflammation, are therefore important therapeutic targets. Several key physiological parameters require monitoring and intensive management during various phases of treatment to ameliorate secondary injury mechanisms and potentially protect against further neuronal injury. This chapter reviews the core physiological targets in the management of brain and spinal cord injury and relates them to secondary injury mechanisms and outcomes.
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31

Case of severe concussion from a fall, with subsequent extravasation of the spinal cord: Death in thirteen months after the injury. [Montreal?: s.n.], 1985.

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32

Case of severe concussion from a fall, with subsequent extravasation of the spinal cord: Death in thirteen months after the injury. [Montreal?: s.n.], 1985.

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33

Jacqueline, Sullivan, and Uustal Diann B, eds. Spinal cord injury. Philadelphia: W.B. Saunders, 1990.

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34

Lydia, Thomas, ed. Spinal cord injury. London: Boxtree, 1994.

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35

Spinal Cord Injury. Elsevier, 2012.

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36

Spinal Cord Injury. American Physical Therapy Association, 2002.

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37

Naftchi, N. Eric. Spinal Cord Injury. Springer, 2012.

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38

Buschbacher, Ralph. Spinal Cord Injury. Springer Publishing Company, Incorporated, 2010.

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39

American Occupational Therapy Association. Practice Division., ed. Spinal cord injury. Rockville, Md. (1383 Piccard Dr., P.O. Box 1725, Rockville 20849-1725): The Association, 1992.

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40

N, Bryce Thomas, ed. Spinal cord injury. New York: Demos, 2010.

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41

Spinal Cord Injury. Elsevier, 2012. http://dx.doi.org/10.1016/c2009-0-35615-9.

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42

Harrison, Simon C. W. Spinal cord injury. Edited by Christopher R. Chapple. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0045.

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Injury to the spinal cord carries a high risk of lower urinary tract dysfunction, which will either be due to damage to the sacral segments of the cord (conus injuries) or partial or complete disconnection of the sacral parasympathetic and somatic centres from the brain centres that coordinate lower urinary tract function (supraconal injuries). As a result, spinal cord injury (SCI) causes urinary symptoms such as urinary retention or incontinence, but can also lead to renal deterioration unless managed appropriately. Long-term urinary tract management has to take into account the nature of the patient’s neurological dysfunction, their personal preferences, and the result of urodynamic evaluation of the lower urinary tract.
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43

V, Adkins Hazel, ed. Spinal cord injury. New York: Churchill Livingstone, 1985.

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44

Spinal Cord Injury. Washington, D.C.: National Academies Press, 2005. http://dx.doi.org/10.17226/11253.

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45

Verhaagen, Joost, and McDonald John W. III. Spinal Cord Injury. Elsevier, 2012.

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46

Naftchi, N. E. Spinal Cord Injury. Springer London, Limited, 2012.

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47

Meigh, Abigail E., Ingrid A. Fitz-James Antoine, and Veronica Carullo. Pediatric Spine Surgery. Edited by David E. Traul and Irene P. Osborn. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190850036.003.0016.

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In children, the most common indication for spinal fusion is significant scoliotic curvature, either idiopathic or as a result of neuromuscular disease. Spinal fusion is high-risk surgery, which can be further complicated by comorbid disease. It carries substantial risk for significant fluid shifts, high intraoperative blood loss, physiologic strain secondary to duration and positioning, severe postoperative pain, and potential spinal cord injury. To mitigate risk and optimize outcomes, these patients should be carefully evaluated by the anesthetic team preoperatively and a comprehensive perioperative plan established. To protect the spinal cord and predict poor neurologic outcomes, the majority of these cases employ intraoperative neuromonitoring. The specific anesthetic agents to allow maximal neuromonitoring signals while ensuring adequate anesthetic depth and pain control should also be established collaboratively. These patients experience severe postoperative pain, and a multimodal approach to therapy should be employed to allow for expedited recovery and decreased length of stay.
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48

Hofstoetter, Ursula S., and Karen Minassian, eds. Spinal Cord Injury and Transcutaneous Spinal Cord Stimulation. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-4756-5.

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49

Abcejo, Arnoley S., and Jeffrey J. Pasternak. Neurogenic Shock. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0072.

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Neurogenic shock is a pathophysiologic state of systemic hypoperfusion characterized by a significant decrease in systemic vascular resistance secondary to loss of sympathetic tone. Neurogenic shock is most commonly seen in the setting of acute spinal cord injury (SCI) but can also occur following significant brain injury. Interruption of sympathetic fibers causes loss of basal vascular sympathetic tone, commonly allowing unopposed parasympathetic tone. As a result, severe hypotension and bradycardia can further exacerbate neurologic injury and organ perfusion. Understanding the physiologic and anatomic changes of neurogenic shock can help direct appropriate resuscitation efforts. Physiologic goals should focus on reversing hypotension, preventing hypoxia, and optimizing perfusion of the injured central nervous system and other critical organs.
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50

S, Albin Maurice, ed. Acute spinal cord injury. Philadelphia: W.B. Saunders, 1987.

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