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1

Caputo, N., M. Hamam, R. Scatolini, G. Giordano, and E. Ciorba. "Ruolo delle lesioni carotidee tandem nell'incidenza dell'ictus perioperatorio e nella recidiva dell'ictus." Rivista di Neuroradiologia 9, no. 1 (1996): 53–58. http://dx.doi.org/10.1177/197140099600900106.

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Gli autori riferiscono i risultati relativi ad uno studio effettuato su una casistica di 45 pazienti vascolari sintomatici, sottoposti ad intervento di TEA carotideo e controllati clinicamente per 5 anni con lo scopo di verificare se la presenza di lesioni ateromasiche intracraniche associate a quelle delle biforcazioni carotidee era in grado di condizionare l'incidenza dell'ictus perioperatorio o della recidiva dell'ictus. Sugli 85 assi carotidei valutati angiograficamente in fase preoperatoria 53 erano portatori di lesioni tandem; 55 assi carotidei sono stati operati e 30 non sono stati oper
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2

Perre, Enrico, Matteo Ferrari, Emanuele Filice, Giacomo Stera, Rosa Francavilla, and Chiara Ghizzi. "Incremento delle infezioni pediatriche da streptococco di gruppo A e complicanze trombotiche: studio restrospettivo e case series di trombosi dei seni venosi cerebrali." Medico e Bambino Pagine elettroniche 28, no. 1 (2025): 24–27. https://doi.org/10.53126/mebxxviiig24.

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During the 2022 winter, Europe experienced a surge in invasive group A streptococcal (iGAS) infections in paediatric patients, accompanied by reports of severe complications such as cerebral venous sinus thrombosis (CVST). This study retrospectively analysed the cases of four patients with CVST secondary to otogenic infections due to Streptococcus pyogenes, who were admitted between November 2022 and March 2023 at the Bologna Ospedale Maggiore. All patients presented with sepsis signs and otogenic symptoms, with imaging confirming CVST. Treatment included broad-spectrum antibiotics, anticoagul
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3

Tison, Tiziana, Piero Marson, and Giustina De Silvestro. "Lo scambio eritrocitario." Giornale di Clinica Nefrologica e Dialisi 25, no. 4_suppl (2013): S27—S29. http://dx.doi.org/10.33393/gcnd.2013.1086.

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Lo scambio eritrocitario è una procedura in cui, utilizzando un separatore cellulare, si rimuovono i globuli rossi anomali del paziente, che vengono rimpiazzati con globuli rossi di un donatore volontario. Lo scambio eritrocitario può essere effettuato sia utilizzando accessi venosi periferici che un catetere venoso centrale. Dal momento che spesso si tratta di pazienti pediatrici è importante valutare attentamente le indicazioni ed è necessario considerare alcuni aspetti particolari della procedura aferetica. Lo scambio eritrocitario è indicato in caso di complicanze severe della drepanocitos
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4

SAPONARO, G., G. GASPARINI, D. CERVELLI, et al. "Il lembo libero osteoperiosteo di Fibula come opzione ricostruttiva preprotesica nelle atrofie severe e nei difetti post oncologici dei mascellari." Acta Otorhinolaryngologica Italica 35, no. 6 (2015): 394–99. http://dx.doi.org/10.14639/0392-100x-763.

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Il gold standard nella ricostruzione dei mascellari nelle atrofie severe, siano esse di natura idiopatica o iatrogena, come nei casi di chirurgia resettiva oncologica, deve essere incentrato verso tecniche di ricostruzione immediata che consentano un veloce recupero funzionale ed estetico. I pazienti considerati in questo studio sono stati trattati durante un periodo di 5 anni (2010-2014) con ricostruzione immediata del deficit dei mascellari, eseguito per mezzo di lembo libero di fibula osteo-periosteo. Sono stati pertanto selezionati 14 pazienti sottoposti a ricostruzione con tale tecnica, s
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5

Scavuzzo, A., A. Granata, A. Saita, and F. Fiorini. "Complicanze della nefrolitotrissia percutanea." Giornale di Clinica Nefrologica e Dialisi 23, no. 2 (2018): 38–43. http://dx.doi.org/10.33393/gcnd.2011.1436.

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L'obiettivo di questo studio è descrivere “step-by-step” la nefrolitotrissia percutanea e le sue complicanze. A tale proposito sono stati valutati i casi di calcolosi renale da noi trattati con nefrolitotrissia percutanea (PCNL) dal 2001 al 2010 ed è stata al contempo rivista la letteratura circa l'incidenza e il management delle complicanze legate a tale procedura. La percentuale globale di complicanze registrate durante e dopo le PCNL possono raggiungere anche l'83% dei casi e comprendono ematomi (7,2%), trasfusioni (11,2%-17,5%) e febbre (21,0%-32,0%). Molte di queste complicazioni, se rico
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6

Barca, Maria, Maria Boccia, Marta Improta, and Valentina Discepolo. "Crisi celiaca: una complicanza rara e insidiosa della celiachia." Medico e Bambino Pagine elettroniche 27, no. 4 (2024): 59–63. http://dx.doi.org/10.53126/mebxxviia59.

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Coeliac Crisis is an urgent and potentially fatal complication of Coeliac Disease (CeD), which is most frequent in early childhood. The crisis may occur at onset or develop in CeD patients with poor compliance to the gluten-free diet (GFD). Stress, surgery and infections can act as triggers. The diagnosis is based on the acute onset of rapidly progressive diarrhoea associated with at least two conditions among severe dehydration, metabolic acidosis, dyselectrolytemia, renal dysfunction, neurological alterations, hypoproteinemia and weight loss. Haematological manifestations, such as thrombocyt
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7

BELLINI, FRANCESCA, ALBERTO CAL, ALESSIA LIVERINI, and SARA ZACCHETTI. "V.21 N.1.(2022) APPROCCIO “ONE HEALTH”." Rassegna di Diritto, Legislazione e Medicina Legale Veterinaria 21, no. 1 (2022): 1–42. http://dx.doi.org/10.54103/0300-3485/23039.

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(ENG)Toxoplasmosis is a food zoonosis caused by the gondii Toxoplasma, a parasite that completes its life cycle within the cells of the hosting organism. Toxoplasmosis represents an emerging disease and its diffusion is closely linked to lack of hygienic conditions, eating habits and hot-humid climates that favour the spreading of the parasite in the environment. The majority of people who contract the disease have no symptoms and therefore do not require any therapy. On the other hand, however, in immunosuppressed persons, in pregnant women and in infants with congenital infection, therapeuti
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8

Ianache, Irina, and Cristiana Oprea. "COMPLICAŢIE NEUROLOGICĂ SEVERĂ LA O TÂNĂRĂ CU INFECŢIE HIV." Romanian Journal of Infectious Diseases 19, no. 4 (2016): 266–72. http://dx.doi.org/10.37897/rjid.2016.4.11.

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Introducere: Managementul pacienţilor cu infecţie HIV şi sindrom inflamator de reconstituţie imună (IRIS) reprezintă încă o provocare, în special la pacienţii cu infecţii oportuniste cerebrale. Prezentare de caz: Prezentăm cazul unei tinere în vârstă de 26 de ani, diagnosticată cu infecţie HIV într-un serviciu de hematologie şi internată în clinică noastră cu anemie severă, anxietate şi depresie. Probele biologice la internare au evidenţiat o anemie importantă, imunodepresie severă (CD4+ 63/mm3) şi o viremie HIV crescută (6,25 log10 copii/mL). După o lună de la iniţierea terapiei antiretrovira
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9

Rajendram, Rajkumar, Arif Hussain, Naveed Mahmood, and Gabriele Via. "Dynamic right-to-left interatrial shunt may complicate severe COVID-19." BMJ Case Reports 14, no. 10 (2021): e245301. http://dx.doi.org/10.1136/bcr-2021-245301.

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Right-to-left (RTL) interatrial shunt (IAS) may complicate select cases of COVID-19 pneumonia. We describe the use of serial imaging to monitor shunt in critically ill patients. A 52-year-old man presented with COVID-19 pneumonia. Hypoxia worsened despite maximal medical therapy and non-invasive ventilation. On day 8, saline microbubble contrast-enhanced transthoracic echocardiography revealed a patent foramen ovale (PFO) with RTLIAS. Invasive ventilation was initiated the next day. The course was complicated by intermittent severe desaturation without worsening aeration or haemodynamic instab
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10

Foresman, Ryan N., and Christopher W. Connors. "Severe Pulmonary Hypertension and Right Ventricular Failure Complicate a Total Abdominal Hysterectomy." Seminars in Cardiothoracic and Vascular Anesthesia 15, no. 4 (2011): 179–82. http://dx.doi.org/10.1177/1089253211424223.

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Objective: The 2007 American College of Cardiology/American Heart Association guidelines report that no significant studies have been conducted assessing the perioperative risk of pulmonary hypertension in noncardiac surgery. However, the presence of right ventricular failure has been well documented to have poor prognostic implications. The presence of pulmonary hypertension and right ventricular failure present unique perioperative challenges. These include maintenance of adequate cardiac function, acid–base management, intraoperative monitoring, and postoperative pain management. Case repor
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11

Barbera, V., G. Barbera, G. Otranto, et al. "Calcifilassi peniena: una rara complicanza in corso di emodialisi." Giornale di Clinica Nefrologica e Dialisi 24, no. 1 (2018): 9–12. http://dx.doi.org/10.33393/gcnd.2012.1106.

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La calcifilassi rappresenta una condizione clinica severa ed assai grave che si manifesta prevalentemente - ma non esclusivamente - in pazienti affetti da malattia renale cronica (CKD) sottoposti a terapia sostitutiva. Colpisce circa 1′1– 4% della popolazione dialitica (1, 2) e presenta una mortalità assai elevata (60–80%) (3). È caratterizzata clinicamente dalla presenza di ulcerazioni ischemiche a carico della cute e da necrosi conseguente allo sviluppo di calcificazioni distrofiche delle arteriole sottocutanee. L'interessamento penieno è assai raro ed in letteratura ne sono riportate - fino
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12

Hardeman, A., A. Finley, and M. Huntwork. "M303 LANGUAGE BARRIERS COMPLICATE FOOD ALLERGY TESTING IN CASES OF SEVERE ATOPIC DERMATITIS." Annals of Allergy, Asthma & Immunology 127, no. 5 (2021): S125—S126. http://dx.doi.org/10.1016/j.anai.2021.08.402.

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13

Carvalho, Joana, Rita Moinho, Patricia Macao, and Guiomar Oliveira. "When snakebites complicate: a paediatric case with shock and compartment syndrome." BMJ Case Reports 14, no. 2 (2021): e240206. http://dx.doi.org/10.1136/bcr-2020-240206.

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We report the case of an 11-year-old boy brought to our emergency department 2 hours after a viper bite to his right hand. He suffered severe pain and rapidly progressive swelling with signs of haemodynamic compromise in keeping with distributive shock. The oedema progressed from his right wrist upwards to his forearm and upper arm with compartment syndrome ultimately resulting. He underwent fasciotomy of the right upper limb and antivenom serum was given. The patient required vasopressors for 48 hours and a total of nine surgical interventions were necessary. In the event of a snakebite, it i
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14

Marras, L. C., T. P. Kalaparambath, S. E. Black, and D. W. Rowed. "Severe Tension Pneumocephalus Complicating Frontal Sinus Osteoma." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 25, no. 1 (1998): 79–81. http://dx.doi.org/10.1017/s0317167100033540.

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ABSTRACT:Background:Tension pneumocephalus, the accumulation of intracranial gas under pressure, is a rare but potentially life-threatening condition which can complicate craniofacial surgery, trauma, or cranial tumor. It presents as an acute or subacute expanding mass lesion.Case Report:We present a case of a 40-year-old male who developed tension pneumocephalus as a consequence of a previously detected but untreated frontal sinus osteoma. Despite prompt decompression and repair of the fistulous connection between the sinus and the intracranial compartment, the patient suffered permanent fron
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15

Shustov, Sergey B., Zulfiya R. Shafigullina, Anna N. Vydrych, Aleksandr A. Lisitsyn, and Alisa N. Semenova. "Pheochromocytoma in combination with severe aortic insufficiency: clinical case." HERALD of North-Western State Medical University named after I.I. Mechnikov 16, no. 1 (2024): 87–93. http://dx.doi.org/10.17816/mechnikov626645.

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Pheochromocytoma is a rare neuroendocrine tumor of the adrenal medulla with widespread cardiac complications. Dilation of the heart chambers can cause valve defects. At the same time, severe cardiac comorbid conditions that complicate the choice of treatment tactics for patients are not sufficiently described in the literature. A clinical case of pheochromocytoma in combination with severe aortic insufficiency in a man admitted to the endocrinology department is presented. In conditions of aortic insufficiency, the risk of surgical intervention is extremely high. After a thorough analysis of c
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16

SOARES, José Evandro Silva, and Denise Martin COVIELLO. "FAMILY PERCEPTIONS OF THE ROLE OF PSYCHIATRIC HOSPITALS IN THE READMISSIONS OF PATIENTS WITH SEVERE MENTAL DISORDERS." Boletim de Conjuntura (BOCA) 21, no. 63 (2025): 89–113. https://doi.org/10.5281/zenodo.15066967.

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This qualitative study investigates the perceptions of family members regarding the role of psychiatric hospitals in the readmissions of patients with severe mental disorders, analyzing the reasons why families continue to rely on hospitalization despite deinstitutionalization policies. The research was conducted at a psychiatric hospital in Campina Grande, PB, involving 30 family members of patients with a history of multiple readmissions. Semi-structured interviews and ethnographic observations were conducted during family visits to the hospital. Data analysis was performed using content ana
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17

Fakhouri, Eddie W., Stephen J. Peterson, Janish Kothari, Ragin Alex, Joseph I. Shapiro, and Nader G. Abraham. "Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine Storm." Antioxidants 9, no. 7 (2020): 636. http://dx.doi.org/10.3390/antiox9070636.

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Coronaviruses are very large RNA viruses that originate in animal reservoirs and include severe acute respiratory distress syndrome (SARS) and Middle East respiratory syndrome (MERS) and other inconsequential coronaviruses from human reservoirs like the common cold. SARS-CoV-2, the virus that causes COVID-19 and is believed to originate from bat, quickly spread into a global pandemic. This RNA virus has a special affinity for porphyrins. It invades the cell at the angiotensin converting enzyme-2 (ACE-2) receptor and binds to hemoproteins, resulting in a severe systemic inflammatory response, p
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18

Ceccato, Adrian, Marta Camprubí-Rimblas, Elena Campaña-Duel, Aina Areny-Balagueró, Luis Morales-Quinteros, and Antonio Artigas. "Anticoagulant Treatment in Severe ARDS COVID-19 Patients." Journal of Clinical Medicine 11, no. 10 (2022): 2695. http://dx.doi.org/10.3390/jcm11102695.

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Patients with COVID-19 may complicate their evolution with thromboembolic events. Incidence of thromboembolic complications are high and also, patients with the critically-ill disease showed evidence of microthrombi and microangiopathy in the lung probably due to endothelial damage by directly and indirectly injured endothelial and epithelial cells. Pulmonary embolism, deep venous thrombosis and arterial embolism were reported in patients with COVID-19, and several analytical abnormal coagulation parameters have been described as well. D-dimer, longer coagulation times and lower platelet count
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Patel, Roshan, and Rohit Malliwal. "Severe hyponatraemia and autonomic dysreflexia in a quadriplegic person." BMJ Case Reports 12, no. 6 (2019): e228209. http://dx.doi.org/10.1136/bcr-2018-228209.

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Spinal cord injury (SCI) is associated with a range of secondary health issues. Altered neurological function can complicate diagnosis, which may have serious consequences. Here we present the case of a tetraplegic person presenting with confusion and bradycardia. Initial testing revealed severe hyponatraemia (sodium 96 mmol/L) and ST elevation associated with labile blood pressure. Delayed further investigation identified sigmoid volvulus—endoscopic decompression led to resolution of haemodynamic lability and a diagnosis of autonomic dysreflexia. Low mood and poor documentation in the communi
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20

Kulkarni, Noopur N., Bhakti U. Sarangi, and Ajay A. Walimbe. "Severe hypertriglyceridemia in an adolescent female with diabetic ketoacidosis: A case report." Journal of Pediatric Critical Care 11, no. 5 (2024): 238–40. http://dx.doi.org/10.4103/jpcc.jpcc_50_24.

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Abstract Severe hypertriglyceridemia (SHT) is a rare metabolic complication of diabetic ketoacidosis (DKA) and may complicate the course by leading to acute pancreatitis. While intravenous insulin typically treats the dyslipidemia in these cases, the role of lipid-lowering agents to prevent adverse outcomes in patients not responding to insulin warrants further investigation. We report the case of an adolescent girl who presented to us with DKA and SHT (8639 mg/dL), requiring intravenous insulin as well as fibrates. She did not develop any complications that could be attributed to diabetic lip
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D'Arena, Giovanni, Giuseppe Pietrantuono, Emilio Buccino, Giancarlo Pacifico, and Pellegrino Musto. "Fournier's Gangrene Complicating Hematologic Malignancies: Literature Review and Treatment Suggestions." Mediterranean Journal of Hematology and Infectious Diseases 5, no. 1 (2013): e2013067. http://dx.doi.org/10.4084/mjhid.2013.067.

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Fournier’s gangrene (FG) is a rare but severe necrotizing fasciitis of the external genitalia that may complicate the clinical course of hematologic malignancies and sometimes may be the first sign of the disease. The clinical course of FG is very aggressive and the mortality is still high despite the improvement in its management. Early recognition of FG and prompt appropriate treatment with surgical debridement and administration of antibiotics are the cornerstone of the management of this very severe disease.
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22

Hoy, Michael, Kate Flavin, and Venkat Prasad. "A complex obstetric case." Journal of the Intensive Care Society 18, no. 3 (2017): 239–43. http://dx.doi.org/10.1177/1751143717700910.

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A 33-year-old primigravida presented with severe sepsis, severe pre-eclampsia, peripartum cardiomyopathy and the haemolysis, elevated liver enzymes and low platelets syndrome manifesting over the course of 24 h causing a diagnostic conundrum and a difficult sequence of physiological problems to overcome. We describe a previously unreported sequence of events involving a pre-eclamptic, septic parturient to improve anaesthetic and intensive care physician awareness of confounding factors that complicate assessment and management of these patients.
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23

Chacko, Anita R., Peter H. Zwart, Randy J. Read, Eleanor J. Dodson, C. D. Rao, and Kaza Suguna. "Severe diffraction anisotropy, rotational pseudosymmetry and twinning complicate the refinement of a pentameric coiled-coil structure of NSP4 of rotavirus." Acta Crystallographica Section D Biological Crystallography 68, no. 11 (2012): 1541–48. http://dx.doi.org/10.1107/s090744491203836x.

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The crystal structure of the region spanning residues 95–146 of the rotavirus nonstructural protein NSP4 from the asymptomatic human strain ST3 was determined at a resolution of 2.5 Å. Severe diffraction anisotropy, rotational pseudosymmetry and twinning complicated the refinement of this structure. A systematic explanation confirming the crystal pathologies and describing how the structure was successfully refined is given in this report.
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24

Kalimuddin, Shirin, Yii Ean Teh, Liang En Wee, et al. "Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness." PLOS Neglected Tropical Diseases 16, no. 8 (2022): e0010724. http://dx.doi.org/10.1371/journal.pntd.0010724.

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Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain poorly defined. We prospectively enrolled 209 patients with acute dengue (n = 48; one with severe dengue) and other acute viral respiratory infections (ARI) (n = 161), and followed them up for chronic sequelae up to one year post-enrolment, prior to the onset of the Covid-19 pandemic. Baseline demog
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Eyer-Silva, Walter A., Jorge Francisco C. Pinto, Juçara Árabe, and Carlos Alberto Morais-de-Sá. "Paradoxical reaction to the treatment of tuberculosis uncovering previously silent meningeal disease." Revista da Sociedade Brasileira de Medicina Tropical 35, no. 1 (2002): 59–61. http://dx.doi.org/10.1590/s0037-86822002000100011.

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The development of paradoxical clinical worsening following initiation of tuberculosis treatment may complicate the clinical course of both HIV-infected and uninfected patients. We report a severe manifestation of the so called paradoxical reaction to the treatment of tuberculosis that unmasked previously silent meningeal disease in a 34-year-old HIV-infected male patient.
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Braunthal, Stephanie, and Andrei Brateanu. "Hypertension in pregnancy: Pathophysiology and treatment." SAGE Open Medicine 7 (January 2019): 205031211984370. http://dx.doi.org/10.1177/2050312119843700.

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Hypertensive disorders of pregnancy, an umbrella term that includes preexisting and gestational hypertension, preeclampsia, and eclampsia, complicate up to 10% of pregnancies and represent a significant cause of maternal and perinatal morbidity and mortality. Despite the differences in guidelines, there appears to be consensus that severe hypertension and non-severe hypertension with evidence of end-organ damage need to be controlled; yet the ideal target ranges below 160/110 mmHg remain a source of debate. This review outlines the definition, pathophysiology, goals of therapy, and treatment a
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Hollen, Chris, Jessica Rice, Michelle Park, and Vijayshree Yadav. "Rituximab for treatment of refractory multiple sclerosis relapses during pregnancy." Multiple Sclerosis Journal 27, no. 10 (2021): 1620–23. http://dx.doi.org/10.1177/1352458521998937.

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Case Summary: While multiple sclerosis (MS) disease activity declines during pregnancy, there are situations where MS relapses in pregnant women do occur. Mild relapses may be managed with close observation, but severe refractory relapses may require more aggressive management. We describe two cases of rituximab used for severe, refractory multiple sclerosis relapses during pregnancy. Rituximab did not appear to complicate either pregnancy and there were no further relapses for either women. Rituximab should not be overlooked in rare refractory cases, such as the rebound relapses sometimes see
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Zakynthinos, E., T. Vassilakopoulos, P. Kaltsas, et al. "Pulmonary hypertension, interstitial lung fibrosis, and lung iron deposition in thalassaemia major." Thorax 56, no. 9 (2001): 737–39. http://dx.doi.org/10.1136/thx.56.9.737.

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Although restrictive lung disease is the predominant abnormality of pulmonary function in patients with thalassaemia major (TM), its aetiology and its association with pulmonary hypertension (PH) detected in some patients with TM remains unknown. We report a patient with TM, iron overload, frequent pulmonary infections, and progressive severe precapillary PH over the previous 5 years. A severe restrictive pattern and interstitial lung fibrosis were revealed by pulmonary function tests and high resolution computed tomography, respectively. This presentation suggests that interstitial fibrosis m
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Andaev, E. I., R. V. Adelshin, and S. V. Balakhonov. "Severe Fever with Thrombocytopenic Syndrome: Current Epidemiological Situation." Epidemiology and Vaccinal Prevention 20, no. 4 (2021): 114–22. http://dx.doi.org/10.31631/2073-3046-2021-20-4-114-122.

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Relevance. Severe fever with thrombocytopenia syndrome is a viral disease characterized by acute fever, accompanied by progressive thrombocytopenia, leucopenia. The mortality is up to 30%. The disease was first identified in 2009 in rural areas of central China, Hubei and Henan. The causative agent of the disease is a new Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV). The SFTSV is mainly transmitted through tick bites, especially Haemaphysalis longicornis which is the dominant tick species in East Asia.The aim of the review is to analyze relevant information about Severe Fever with
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Cofoian-Amet, Zela, Cristina Mitu, Elena Rosianu, Ayghiul Mujdaba-Elmi, and Bogdan O. Popescu. "Advanced atherosclerosis and stroke in a young patient with cutaneous lymphoma." Romanian Journal of Neurology 13, no. 2 (2014): 72–74. http://dx.doi.org/10.37897/rjn.2014.2.5.

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Atherosclerosis might begin in childhood with the development of fatty streaks. However, the advanced lesions of atherosclerosis, which complicate with ischemic events, are frequent rather in the elderly. We report here a case of early severe and symptomatic atheromatosis of large cervical vessels, in a young patient with some risk factors and strong familial history of vascular disease who was diagnosed with Sezary syndrome.
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Valero, Nereida Josefina, Lisbeth Georgina Polanco Peláez, and Marcos Jacob Sacan Arriola. "LINFOHISTIOCITOSIS HEMOFAGOCÍTICA ASOCIADA AL DENGUE GRAVE." Enfermería Investiga 6, no. 4 (2021): 65. http://dx.doi.org/10.31243/ei.uta.v6i4.1207.2021.

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La linfohistiocitosis hemofagocítica (LHH) es una enfermedad que afecta al sistema inmunitario, a través de la activación macrofágica descontrolada, con falla en las funciones de las células asesinas natural killer (NK) y los linfocitos T citotóxicos. El dengue es la arbovirosis de mayor impacto en salud pública, que se presenta en áreas tropicales del mundo. El objetivo de esta investigación fue analizar la asociación de la linfohistiocitosis hemofagocítica a la severidad del dengue, síntomas y diagnóstico. Se aplicó una metodología con diseño documental con revisión sistemática de la bibliog
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Cherniy, V. I. "The modern concept of intensive therapy of coagulopathy, which is complicate polytrauma and shock." Клінічна та профілактична медицина 2, no. 8 (2019): 4–15. http://dx.doi.org/10.31612/2616-4868.2(8).2019.01.

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The statute presents the fourth edition (The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition, 2016) of European recommendations on the treatment of severe blood loss and coagulopathy caused by injury. More than 50% of all trauma patients with a fatal outcome die within 24 hours after injury. After hospitalization in a third of patients with trauma, the bleeding is coagulopathic. They significantly increase the risk of multiple organ failure and death compared with patients with similar trauma in the absence of coagulopathy. Early acute coagu
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33

Glad Smart Moussounda Mpika, Maryem Hindi, Nidal Ouakil, Oussama Fikri, and Lamyae Amro. "Asthma exacerbation complicated by pneumomediastinum: Case report." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 1887–90. http://dx.doi.org/10.30574/wjarr.2024.21.1.0149.

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Spontaneous pneumomediastinum is a rare entity that can complicate an asthma attack and can occur in young adults or adolescents. The abrupt onset of pneumomediastinum is usually associated with dyspnea, cough and chest pain. We report a case of severe asthma attack complicated by spontaneous pneumomediastinum in a 25-year-old female patient. Chest X-ray and CT scan confirmed the diagnosis. Progression was favorable within 6 days of treatment
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34

Golanova, K. V., D. V. Sashin, E. A. Nechipay, and N. V. Garanina. "Progressive Multifocal Leukoencephalopathy: Literature Review and Clinical Case Study." Journal of oncology: diagnostic radiology and radiotherapy 7, no. 4 (2024): 54–61. https://doi.org/10.37174/2587-7593-2024-7-4-54-61.

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Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system, primarily affecting individuals with severe immunosuppression. Its subacute onset, nonspecific clinical manifestations, and MRI findings complicate accurate and timely diagnosis. This review provides a brief overview of the etiology and fundamental pathogenesis of the disease, demonstrating through a clinical case the importance of a multimodal approach and the potential challenges in the differential diagnosis of PML.
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35

Glad, Smart Moussounda Mpika, Hindi Maryem, Ouakil Nidal, Fikri Oussama, and Amro Lamyae. "Asthma exacerbation complicated by pneumomediastinum: Case report." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 1887–90. https://doi.org/10.5281/zenodo.13352669.

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Spontaneous pneumomediastinum is a rare entity that can complicate an asthma attack and can occur in young adults or adolescents. The abrupt onset of pneumomediastinum is usually associated with dyspnea, cough and chest pain. We report a case of severe asthma attack complicated by spontaneous pneumomediastinum in a 25-year-old female patient. Chest X-ray and CT scan confirmed the diagnosis. Progression was favorable within 6 days of treatment
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36

Askin, Cyrus Ashraf, Jerome Craig Edelson, Guy Smith Dooley, and Amy Nicole Stratton. "UnMASking the diagnosis: Acute severe necrotizing pancreatitis in the setting of systemic lupus erythematosus complicated by macrophage activation syndrome." Case Reports in Internal Medicine 5, no. 4 (2018): 1. http://dx.doi.org/10.5430/crim.v5n4p1.

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Systemic lupus erythematosus (SLE) is a common rheumatologic condition with known GI involvement. Acute pancreatitis (AP) is a rare GI complication of SLE and is typically associated with increased disease activity. Macrophage activation syndrome (MAS) is an unusual, hyper-inflammatory response to a rheumatologic stimulus characterized by hyperferritinemia, pancytopenia, thermal dysregulation and multi-organ dysfunction. MAS, more commonly seen in children, has been reported to complicate both adult onset SLE and AP. We present a case of necrotizing AP secondary to an SLE flare complicated by
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Mamun, SM AA, Zafor Iqbal, Arif Mahmood, and Sania Ahsan. "Post-COVID19 Lung Fibrosis: An Worrying Experience of COVID19 Survivors." Bangladesh Journal of Medicine 33, no. 1 (2021): 114–19. http://dx.doi.org/10.3329/bjm.v33i1.56801.

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Patients recovering from confirmed COVID19 particularly moderate to severe disease, those treated in HDU / ICU support with high flow nasal cannula & Mechanical ventilation ,experienced different symptoms ranging from tiredness, fatigue to severe exertional dyspnea. High resolution CT scan of Chest of these such patients showed persistent radiological abnormalities simulating progressive fibrotic lung disease. Lung function including CO transfer factor revealed moderate to severe reduction. In case of patients recovered from moderate to severe COVID19 pneumonia, lung fibrosis is a big prob
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38

Volpi, Sara, Jason M. Ali, Alishah Suleman, and Rahim Nadeem Ahmed. "Pneumomediastinum in COVID-19 patients: a case series of a rare complication." European Journal of Cardio-Thoracic Surgery 58, no. 3 (2020): 646–47. http://dx.doi.org/10.1093/ejcts/ezaa222.

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Abstract Pneumomediastinum is a rare clinical finding, but one which can be the source of significant concern for clinicians. By presenting 3 such cases, we highlight that pneumomediastinum can complicate the course of a severe coronavirus disease 2019 infection but emphasize that conservative management is the first-line method of treatment, with gradual resorption of the air from the tissues. It is important to be alert to the development of pneumothorax, which will require drainage.
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39

She, Tianyu, Stephanie Ren, Harry He, Matthew Symer, and Seymour Katz. "Ulcerative Colitis or Not? A Case of Dysplasia, Gastrointestinal Bleeding, and Juvenile Polyposis in a 27-Year-Old Man." ACG Case Reports Journal 11, no. 7 (2024): e01450. http://dx.doi.org/10.14309/crj.0000000000001450.

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ABSTRACT Juvenile polyposis syndrome lies within the family of hamartomatous polyposis syndromes characterized by polyps that appear benign but harbor an increased risk of colorectal and gastric cancer. This 27-year-old man with severe ulcerative colitis was discovered to have concomitant juvenile polyposis syndrome during diagnostic workup for gastrointestinal bleeding. The implications of this rare association complicate both diagnostic and treatment modalities since both diseases confer an increased risk of cancer.
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40

Kim, Seunghoon, Youngbin Lym, and Ki-Jung Kim. "Developing Crash Severity Model Handling Class Imbalance and Implementing Ordered Nature: Focusing on Elderly Drivers." International Journal of Environmental Research and Public Health 18, no. 4 (2021): 1966. http://dx.doi.org/10.3390/ijerph18041966.

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Along with the rapid demographic change, there has been increased attention to the risk of vehicle crashes relative to older drivers. Due to senior involvement and their physical vulnerability, it is crucial to develop models that accurately predict the severity of senior-involved crashes. However, the challenge is how to cope with an imbalanced severity class distribution and the ordered nature of crash severities, as these can complicate the classification of the severity of crashes. In that regard, this study investigates the influence of implementing ordinal nature and handling imbalanced
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Roberson, Megan, and Austin Smith. "Cerebral Malaria in a Patient with Recent Travel to the Congo Presenting with Delirium: A Case Report." Clinical Practice and Cases in Emergency Medicine 4, no. 4 (2020): 533–36. http://dx.doi.org/10.5811/cpcem.2020.8.47995.

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Introduction: Cerebral malaria, a syndrome of altered consciousness, is a rare and severe neurologic complication resulting from Plasmodium falciparum.1 Historically, cerebral malaria has been seen more frequently in children rather than adults. To complicate the diagnosis, cerebral malaria has few specific symptoms and neurologic findings can vary with each case. Case Report: We describe a case of a 61-year-old male who returned from the Democratic Republic of Congo and presented to the emergency department with dehydration, fatigue, and intermittent confusion. He was ultimately diagnosed wit
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Koritarova, V. "APPLICATION OF SPINAL ANESTHESIA FOR CESAREAN SECTION IN PREGNANT WOMAN WITH SEVERE COVID 19 PNEUMONIA - A CASE REPORT." Deutsche internationale Zeitschrift für zeitgenössische Wissenschaft 75 (March 6, 2024): 45–47. https://doi.org/10.5281/zenodo.10788432.

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Pregnancy leads to important physiological and immunological changes, which could complicate viral and bacterial inflections . Many pregnant women with COVID- 19 inflection are asymptomatic. However among those with respiratory symptoms incidence of severe pneumonia, admission in Intensive Care Unit, need of non- invasive and invasive mechanical ventilation are higher than in other population.Maternal respiratory failure may cause fetal distress, which requires urgent Cesarean section. Regional anesthesia is preferred , because it considered safer than general anesthesia for mot
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Mahajan, Kunal, Virender Katyal, Suvrat Arya, and Meha Shrama. "Antiphospholipid Syndrome in a Pregnant Female Presenting with Severe Thrombocytopenia and Bleeding." Case Reports in Medicine 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/234878.

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The antiphospholipid antibody syndrome (APS) is defined by the persistent presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism or pregnancy morbidity. Antithrombotic therapy is the mainstay of treatment given the high risk of recurrent thromboembolism that characterizes this condition. Despite the prothrombotic nature of APS, thrombocytopenia is present in a proportion of patients, which can complicate management and limit the use of antithrombotic therapy. The mechanism of APS-associated thrombocytopenia is multifactorial and its relation to th
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Adjei Boachie, Joseph, and Eduardo Smith-Singares. "Sampson’s Artery Hemorrhage after Inguinal Hernia Repair: Second Case Reported." Case Reports in Surgery 2016 (2016): 1–2. http://dx.doi.org/10.1155/2016/2534037.

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Sampson artery is normally obliterated in postembryonic development. In rare cases it can remain patent and complicate a routine outpatient herniorrhaphy when severed. This is the second reported case in the available English literature of hemoperitoneum due to bleeding from a patent Sampson’s artery following an open inguinal hernia repair.
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45

Radwińska, Justyna, Anna Domosławska, Andrzej Pomianowski, Katarzyna Żarczyńska, and Andrzej Jurczak. "Implications of Blood Coagulation and Fibrinolytic Disorders in Severe Endometritis-Pyometra Complex in Bitches." Bulletin of the Veterinary Institute in Pulawy 56, no. 3 (2012): 293–97. http://dx.doi.org/10.2478/v10213-012-0053-x.

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Abstract Twenty bitches with acute endometritis-pyometra complex (EPC) and 20 clinically healthy bitches were examined. The following coagulation parameters were determined in haemostatic evaluations: prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen concentrations (FBG), D-dimer concentrations (D-D), antithrombin activity (AT), and blood platelet counts (PLT). Morphological and biochemical blood parameters were also analysed. Examinations of animals affected by EPC revealed blood coagulation and fibrinolytic disorders, and the noted results (P
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Sormunen-Harju, Heidi, Krista Sarvas, Niina Matikainen, Nanna Sarvilinna, and E. Kalevi Laitinen. "Adrenal infarction in a healthy pregnant woman." Obstetric Medicine 9, no. 2 (2016): 90–92. http://dx.doi.org/10.1177/1753495x15627959.

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Adrenal infarction is a very rare event but occasionally seen in hypercoagulable states. We present a case of a 31-year-old woman at 38 weeks of gestation who developed a severe upper abdominal pain and unilateral adrenal infarction due to thrombosis of the adrenal vein. The only thrombogenic factor found was pregnancy. The case highlights that adrenal infarction may complicate a normal pregnancy and should be included in the differential diagnosis of the acute abdomen in pregnancy.
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47

Sinkin, Mikhail V., Alexander E. Talypov, Olga O. Kordonskaya, et al. "Electrocorticography in patients with severe traumatic brain injury." Annals of Clinical and Experimental Neurology 14, no. 3 (2020): 66–76. https://doi.org/10.25692/acen.2020.3.9.

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Introduction.The frequency of adverse outcomes in patients with severe traumatic brain injury (TBI) exceeds 25%. Epileptic seizures and vasospasm, in the absence of pathogenetic treatment, cause irreversible brain damage and thus complicate the course of severe TBI. Bedside electroencephalography (EEG) is traditionally used to diagnose these conditions. However, its low spatial resolution when recording from the scalp and a large number of artefacts that make it challenging to analyse the data. Materials and methods.Electrocorticography (ECoG) monitoring was performed using subdural electrodes
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Hidayati, Eka Laksmi, Maulana Rosyady, Henny Adriani Puspitasari, Meilania Saraswati, Angela Grace, and Cahyani Gita Ambarsari. "Plasma exchange and hemodialysis for severe manifestations of multiple wasp stings in a child." Journal of Renal Injury Prevention 9, no. 3 (2020): e27-e27. http://dx.doi.org/10.34172/jrip.2020.27.

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Wasp stings occur frequently in developing countries and often lead to fatal outcomes due to the effects of wasp venom. Hemolysis and rhabdomyolysis often complicate wasp stings and result in acute kidney injury (AKI). We report a case of multiple wasp stings leading to AKI and multiple organ dysfunction syndrome (MODS) in a 9-year-old Indonesian girl. Kidney biopsy revealed acute tubular necrosis and acute interstitial nephritis. Despite delayed admission, she recovered in 33 days after 3 days of intravenous steroid administration, eight sessions of intermittent hemodialysis, and two sessions
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Norouzi, Mahnaz, Shaghayegh Norouzi, Alistaire Ruggiero, et al. "Type-2 Diabetes as a Risk Factor for Severe COVID-19 Infection." Microorganisms 9, no. 6 (2021): 1211. http://dx.doi.org/10.3390/microorganisms9061211.

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The current outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed coronavirus disease 2019 (COVID-19), has generated a notable challenge for diabetic patients. Overall, people with diabetes have a higher risk of developing different infectious diseases and demonstrate increased mortality. Type 2 diabetes mellitus (T2DM) is a significant risk factor for COVID-19 progression and its severity, poor prognosis, and increased mortality. How diabetes contributes to COVID-19 severity is unclear; however, it may be correlated with the effects of hyperglycemia on system
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Recchia, Andreaserena, Marco Cascella, Sabrina Altamura, et al. "Early Diagnosis and Antibiotic Treatment Combined with Multicomponent Hemodynamic Support for Addressing a Severe Case of Lemierre’s Syndrome." Antibiotics 10, no. 12 (2021): 1526. http://dx.doi.org/10.3390/antibiotics10121526.

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A 20-year-old man was admitted to the intensive care unit for septic shock due to Lemierre’s syndrome. It is a rare syndrome that manifests as an upper respiratory infection, although systemic involvement, severe coagulopathy, and multi-organ failure can dangerously complicate the clinical picture. In this syndrome, sepsis-related neuroendocrine dysregulation and microcirculation impairment can have a rapid deleterious progression. Consequently, proper diagnosis, early source control, and appropriate antibiotics administration are mandatory to improve the prognosis. The intensive treatment is
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