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Journal articles on the topic 'Sesamolin'

Author: Grafiati

Published: 30 May 2022

Last updated: 17 April 2024

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1

Rosalina, Reny, and Natthida Weerapreeyakul. "An Insight into Sesamolin: Physicochemical Properties, Pharmacological Activities, and Future Research Prospects." Molecules 26, no. 19 (September 27, 2021): 5849. http://dx.doi.org/10.3390/molecules26195849.

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Sesame seeds are rich in lignan content and have been well-known for their health benefits. Unlike the other sesame lignan compounds (i.e., sesamin and sesamol), the study of the pharmacological activity of sesamolin has not been explored widely. This review, therefore, summarizes the information related to sesamolin’s pharmacological activities, and the mechanism of action. Moreover, the influence of its physicochemical properties on pharmacological activity is also discussed. Sesamolin possessed neuroprotective activity against hypoxia-induced reactive oxygen species (ROS) and oxidative stress in neuron cells by reducing the ROS and inhibiting apoptosis. In skin cancer, sesamolin exhibited antimelanogenesis by affecting the expression of the melanogenic enzymes. The anticancer activity of sesamolin based on antiproliferation and inhibition of migration was demonstrated in human colon cancer cells. In addition, treatment with sesamolin could stimulate immune cells to enhance the cytolytic activity to kill Burkitt’s lymphoma cells. However, the toxicity and safety of sesamolin have not been reported. And there is also less information on the experimental study in vivo. The limited aqueous solubility of sesamolin becomes the main problem, which affects its pharmacological activity in the in vitro experiment and clinical efficacy. Therefore, solubility enhancement is needed for further investigation and determination of its pharmacological activity profiles. Since there are fewer reports studying this issue, it could become a future prospective research opportunity.

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2

Lim, Jin Seon, Yoshikazu Adachi, Yoko Takahashi, and Takashi Ide. "Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats." British Journal of Nutrition 97, no. 1 (January 2007): 85–95. http://dx.doi.org/10.1017/s0007114507252699.

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Effects of sesamin and sesamolin (sesame lignans) on hepatic fatty acid metabolism were compared in rats. Rats were fed either a lignan-free diet, a diet containing 0·6 or 2 g/kg lignan (sesamin or sesamolin), or a diet containing both sesamin (1·4 g/kg) and sesamolin (0·6 g/kg), for 10 d. Sesamin and sesamolin dose-dependently increased the activity and mRNA abundance of various enzymes involved in hepatic fatty acid oxidation. The increase was much greater with sesamolin than with sesamin. These lignans increased parameters of hepatic fatty acid oxidation in an additive manner when added simultaneously to an experimental diet. In contrast, they decreased the activity and mRNA abundance of hepatic lipogenic enzymes despite dose-dependent effects not being necessarily obvious. Sesamin and sesamolin were equally effective in lowering parameters of lipogenesis. Sesamolin accumulated in serum at 33- and 46-fold the level of sesamin at dietary concentrations of 0·6 and 2 g/kg, respectively. The amount of sesamolin accumulated in liver was 10- and 7-fold that of sesamin at the respective dietary levels. Sesamolin rather than sesamin can account for the potent physiological effect of sesame seeds in increasing hepatic fatty acid oxidation observed previously. Differences in bio-availability may contribute to the divergent effects of sesamin and sesamolin on hepatic fatty acid oxidation. Sesamin compared to sesamolin was more effective in reducing serum and liver lipid levels despite sesamolin more strongly increasing hepatic fatty acid oxidation.

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3

Wan, Yuan, Qiaoyun Zhou, Mengge Zhao, and Tao Hou. "Byproducts of Sesame Oil Extraction: Composition, Function, and Comprehensive Utilization." Foods 12, no. 12 (June 15, 2023): 2383. http://dx.doi.org/10.3390/foods12122383.

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Sesame is principally used to generate oil, which is produced by chemical refining or pressing. Sesame meal, as a main byproduct of sesame oil extraction, is usually discarded, causing resource waste and economic loss. Sesame meal is rich in sesame protein and three types of sesame lignans (sesamin, sesamolin, and sesamol). Sesame protein extracted via a physical method and an enzymic method has balanced amino acid composition and is an important protein source, and thus it is often added to animal feed and used as a human dietary supplement. Extracted sesame lignan exhibits multiple biological activities such as antihypertensive, anticancer, and cholesterol-lowering activities, and therefore it is used to improve the oxidative stability of oils. This review summarizes the extraction methods, functional activities, and comprehensive utilization of four active substances (sesame protein, sesamin, sesamolin, and sesamol) in sesame meal with the aim to provide theoretical guidance for the maximum utilization of sesame meal.

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4

Yu, Jing, Hao Sun, Yang Yang, and Yaping Yan. "Sesamolin Alleviates Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites in High-Fat and High-Fructose Diet-Fed Mice." International Journal of Molecular Sciences 23, no. 22 (November 10, 2022): 13853. http://dx.doi.org/10.3390/ijms232213853.

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Nonalcoholic fatty liver disease (NAFLD) has become a major public health problem. The effects of sesamolin on obesity-associated NAFLD and its possible mechanism are still poorly understood. The present study investigated the effects of sesamolin on NAFLD and changes in gut microbiota and serum metabolites in high-fat and high-fructose (HF-HF) diet-fed mice. Mice with NAFLD were treated with or without sesamolin. Sesamolin effectively suppressed obesity-associated metabolic disorder, attenuated hepatic steatosis and the infiltration of inflammatory cells, and decreased levels of hepatic proinflammatory cytokines. Sesamolin also altered the composition of gut microbiota at the genus level. Additionally, differential serum metabolite biomarkers identified in an untargeted metabolomics analysis showed that sesamolin changed the levels of metabolites and influenced metabolomics pathways including caffeine metabolism, steroid hormone biosynthesis, and cysteine and methionine metabolism. Changes in metabolite biomarkers and the abundances of Faecalibaculum, Lachnoclostridium, Mucispirillum, Allobaculum, and Bacteroides are highly correlated with those factors involved in the progression of NAFLD. These results are important in deciphering new mechanisms by which changes in bacteria and metabolites in sesamolin treatment might be associated with the alleviation of obesity-associated NAFLD in HF-HF diet-fed mice. Thus, sesamolin may be a potential compound for obesity-associated NAFLD treatment.

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5

Hadeel, S. Y., S. A. Khalida, and Marie Walsh. "Antioxidant activity of sesame seed lignans in sunflower and flaxseed oils." Food Research 4, no. 3 (December 22, 2019): 612–22. http://dx.doi.org/10.26656/fr.2017.4(3).331.

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This study investigated the antioxidant activity of crude lignan extracts and purified lignans (sesamin, sesamolin, and sesamol) in sunflower and flaxseed oils. Lignan extracts were prepared from roasted sesame seed oil (LRSO) and unroasted sesame seed oil (LUSO). Additionally, the individual lignans were purified from both oils. The crude extracts and purified lignans were added at concentrations of 0.01, 0.02 and 0.03% to the oils and stored at 25 and 65°C over time and peroxide values and thiobarbituric acid values were measured. Each oil showed an increase in oxidation over time, with the samples stored at 65°C exhibiting accelerated oxidation. In general, LRSO showed higher antioxidant activity than LUSO and the antioxidant activity was similar to the antioxidant activity of butylated hydroxytoluene (0.02% BHT) in both oils when used at concentrations of 0.02 and 0.03%. Sesamol showed the highest antioxidant activity of each of the purified lignans followed by sesamin and sesamolin respectively. Crude and purified sesame lignans may have potential applications as natural antioxidants in food systems

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6

Baek, Seung-Hwa, Myung-Gyun Kang, and Daeui Park. "Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses." Current Pharmaceutical Biotechnology 21, no. 2 (February 12, 2020): 169–78. http://dx.doi.org/10.2174/1389201020666191011151123.

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Background: Melanin protects the skin against the harmful effects of ultraviolet irradiation. However, melanin overproduction can result in several aesthetic problems, including melasma, freckles, age spots and chloasma. Therefore, development of anti-melanogenic agents is important for the prevention of serious hyperpigmentation diseases. Sesamolin is a lignan compound isolated from sesame seeds with several beneficial properties, including potential for melanin inhibition. Objective: The aim of this study was to evaluate the anti-melanogenic effect of sesamolin in cell culture in vitro and the underlying mechanism of inhibition using molecular docking simulation. Methods: Melanogenesis was induced by 3-isobutyl-1-methylxanthine in B16F10 melanoma cells, and the inhibitory effects of sesamolin were evaluated using zymography, a tyrosinase inhibitory activity assay, western blotting, and real-time reverse transcription-polymerase chain reaction analysis. Docking simulations between sesamolin and tyrosinase were performed using Autodock vina. Results: Sesamolin significantly inhibited the expression of melanogenesis-related factors tyrosinase, and tyrosinase-related proteins 1 and 2 at the mRNA and protein levels. Treatment of melanoma cells with 50 µM sesamolin demonstrated the strongest inhibition against intercellular tyrosinase and melanin synthesis without exerting cytotoxic effects. Sesamolin significantly reduced mushroom tyrosinase activity in a dose-dependent manner via a competitive inhibition mechanism. Tyrosinase docking simulations supported that sesamolin (-6.5 kcal/mol) bound to the active site of tyrosinase more strongly than the positive control (arbutin, -5.7 kcal/mol). Conclusion: Sesamolin could be developed as a melanogenesis inhibiting agent owing to its dual function in blocking the generation of melanogenesis-related enzymes and inhibiting the enzymatic response of tyrosinase.

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7

Tzen, Jason T. C., Fu-Chou Cheng, Tzyy-Rong Jinn, and Rolis C. W. Hou. "Neuroprotective Effects of Sesamin and Sesamolin on Gerbil Brain in Cerebral Ischemia." International Journal of Biomedical Science 2, no. 3 (September 15, 2006): 284–88. http://dx.doi.org/10.59566/ijbs.2006.2284.

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Sesamin and sesamolin, abundant lignans found in sesame oil, have been demonstrated to possess several bioactivities beneficial for human health. Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated when they were pretreated with sesamin or sesamolin. The neuroprotective effect of sesamin and sesamolin was also observed in vivo using gerbils subjected to a focal cerebral ischemia induced by occlusion of the right common carotid artery and the right middle cerebral artery. Repeated treatment of sesamin or a crude sesame oil extract containing both sesamin and sesamolin significantly reduced the infarct size, visualized via 2,3,5-triphenyltetrazolium chloride staining, by approximately 50% when compared with the control group. These results suggest that sesamin and sesamolin exert effective neuroprotection against cerbral ischemia.

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8

Xu, Fangtao, Rong Zhou, Senouwa Segla Koffi Dossou, Shengnan Song, and Linhai Wang. "Fine Mapping of a Major Pleiotropic QTL Associated with Sesamin and Sesamolin Variation in Sesame (Sesamum indicum L.)." Plants 10, no. 7 (June 30, 2021): 1343. http://dx.doi.org/10.3390/plants10071343.

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Deciphering the genetic basis of quantitative agronomic traits is a prerequisite for their improvement. Herein, we identified loci governing the main sesame lignans, sesamin and sesamolin variation in a recombinant inbred lines (RILs, F8) population under two environments. The content of the two lignans in the seeds was investigated by HPLC. The sesamin and sesamolin contents ranged from 0.33 to 7.52 mg/g and 0.36 to 2.70 mg/g, respectively. In total, we revealed 26 QTLs on a linkage map comprising 424 SSR markers, including 16 and 10 loci associated with sesamin and sesamolin variation, respectively. Among them, qSmin_11.1 and qSmol_11.1 detected in both the two environments explained 67.69% and 46.05% of the phenotypic variation of sesamin and sesamolin, respectively. Notably, qSmin11-1 and qSmol11-1 were located in the same interval of 127-127.21cM on LG11 between markers ZMM1776 and ZM918 and acted as a pleiotropic locus. Furthermore, two potential candidate genes (SIN_1005755 and SIN_1005756) at the same locus were identified based on comparative transcriptome analysis. Our results suggest the existence of a single gene of large effect that controls expression, both of sesamin and sesamolin, and provide genetic information for further investigation of the regulation of lignan biosynthesis in sesame.

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9

Matsumura, Shinichi, Kazuya Murata, Nobuhiro Zaima, Yuri Yoshioka, Masanori Morimoto, Hideaki Matsuda, and Masahiro Iwaki. "Inhibitory Activities of Sesame Seed Extract and its Constituents against β-Secretase." Natural Product Communications 11, no. 11 (November 2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101112.

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The need for a preventive agent against dementia led us to screen natural plant resources. Among the herbs and spices tested, sesame seed prepared from Sesamum indicum seeds showed potent β-secretase inhibitory activity. The active principles were determined to be sesamin and sesamolin, typical lignans in S. indicum. The IC50 values of sesamin and sesamolin were 257 and 140 μM, respectively. These compounds were investigated in a preliminary absorption experiment. After oral administration, these compounds were detected in an intact form in the brain and serum. These results suggest that consumption of sesame seeds may prevent dementia by sesamin and sesamolin, the constituents in sesame seeds.

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10

Junhom, C., B. Siriwarin, N. Weerapreeyakul, and S. Barusrux. "210: Effect of sesamin, sesamolin and sesamol on P-glycoprotein mediated efflux." European Journal of Cancer 50 (July 2014): S48. http://dx.doi.org/10.1016/s0959-8049(14)50181-5.

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11

Srisayam, Montra, Natthida Weerapreeyakul, and Kwanjai Kanokmedhakul. "Inhibition of two stages of melanin synthesis by sesamol, sesamin and sesamolin." Asian Pacific Journal of Tropical Biomedicine 7, no. 10 (October 2017): 886–95. http://dx.doi.org/10.1016/j.apjtb.2017.09.013.

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12

Hofer, Otmar, Gerda Lutz, Günter Brader, and Christoph Kratky. "Conformational Analysis of Tetrahydrofurofuran Lignans: Sesamolin." HETEROCYCLES 45, no. 2 (1997): 287. http://dx.doi.org/10.3987/com-96-7651.

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13

Jeng, K., and R. Hou. "Sesamin and Sesamolin: Natures Therapeutic Lignans." Current Enzyme Inhibition 1, no. 1 (January 1, 2005): 11–20. http://dx.doi.org/10.2174/1573408052952748.

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14

Bedigian, Dorothea, David S. Seigler, and Jack R. Harlan. "Sesamin, sesamolin and the origin of sesame." Biochemical Systematics and Ecology 13, no. 2 (May 1985): 133–39. http://dx.doi.org/10.1016/0305-1978(85)90071-7.

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15

Andargie, Mebeaselassie, Maria Vinas, Anna Rathgeb, Evelyn Möller, and Petr Karlovsky. "Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review." Molecules 26, no. 4 (February 7, 2021): 883. http://dx.doi.org/10.3390/molecules26040883.

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Major lignans of sesame sesamin and sesamolin are benzodioxol--substituted furofurans. Sesamol, sesaminol, its epimers, and episesamin are transformation products found in processed products. Synthetic routes to all lignans are known but only sesamol is synthesized industrially. Biosynthesis of furofuran lignans begins with the dimerization of coniferyl alcohol, followed by the formation of dioxoles, oxidation, and glycosylation. Most genes of the lignan pathway in sesame have been identified but the inheritance of lignan content is poorly understood. Health-promoting properties make lignans attractive components of functional food. Lignans enhance the efficiency of insecticides and possess antifeedant activity, but their biological function in plants remains hypothetical. In this work, extensive literature including historical texts is reviewed, controversial issues are critically examined, and errors perpetuated in literature are corrected. The following aspects are covered: chemical properties and transformations of lignans; analysis, purification, and total synthesis; occurrence in Seseamum indicum and related plants; biosynthesis and genetics; biological activities; health-promoting properties; and biological functions. Finally, the improvement of lignan content in sesame seeds by breeding and biotechnology and the potential of hairy roots for manufacturing lignans in vitro are outlined.

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LUTZ, G., O. HOFER, G. BRADER, and C. KRATKY. "ChemInform Abstract: Conformational Analysis of Tetrahydrofurofuran Lignans: Sesamolin." ChemInform 28, no. 34 (August 3, 2010): no. http://dx.doi.org/10.1002/chin.199734276.

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17

Wu, Ming-Shun, Levent Bless B. Aquino, Marjette Ylreb U. Barbaza, Chieh-Lun Hsieh, Kathlia A. De Castro-Cruz, Ling-Ling Yang, and Po-Wei Tsai. "Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review." Molecules 24, no. 24 (December 4, 2019): 4426. http://dx.doi.org/10.3390/molecules24244426.

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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Kitipaspallop, Wannakarn, Siwapech Sillapaprayoon, Preecha Phuwapraisirisan, Woo-Keun Kim, Chanpen Chanchao, and Wittaya Pimtong. "Developmental effects of sesamolin on zebrafish (Danio rerio) embryos." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 256 (June 2022): 109319. http://dx.doi.org/10.1016/j.cbpc.2022.109319.

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19

Kang, Myung-Hwa, Michitaka Naito, Nobuko Tsujihara, and Toshihiko Osawa. "Sesamolin Inhibits Lipid Peroxidation in Rat Liver and Kidney." Journal of Nutrition 128, no. 6 (June 1, 1998): 1018–22. http://dx.doi.org/10.1093/jn/128.6.1018.

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20

Srisongkram, Tarapong, and Natthida Weerapreeyakul. "Route of intracellular uptake and cytotoxicity of sesamol, sesamin, and sesamolin in human melanoma SK-MEL-2 cells." Biomedicine & Pharmacotherapy 146 (February 2022): 112528. http://dx.doi.org/10.1016/j.biopha.2021.112528.

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21

Lee, Jinyoung, Yoosung Lee, and Eunok Choe. "Effects of sesamol, sesamin, and sesamolin extracted from roasted sesame oil on the thermal oxidation of methyl linoleate." LWT - Food Science and Technology 41, no. 10 (December 2008): 1871–75. http://dx.doi.org/10.1016/j.lwt.2007.11.019.

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22

Shin, Bo Ram, Seung-Ok Yang, Hye-Won Song, Myung-Sub Chung, and Young-Suk Kim. "Effects of adsorbents on benzo(a)pyrene, sesamol, and sesamolin contents and volatile component profiles in sesame oil." Food Science and Biotechnology 24, no. 6 (December 2015): 2017–22. http://dx.doi.org/10.1007/s10068-015-0266-x.

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23

Chantzos, Nickolaos, and Constantinos Georgiou. "Monitoring lipid oxidation events at frying temperatures through radical scavenging assays." Chemical Industry and Chemical Engineering Quarterly 13, no. 3 (2007): 163–66. http://dx.doi.org/10.2298/ciceq0703163c.

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This communication proposes an alternative approach for monitoring oils during thermal stress at frying temperatures through radical scavenging assays. Oxidation events for extra virgin olive, pomace, sesame, sunflower, soybean, corn and of a commercial blend of oils are followed through the DPPH assay during heating at 100, 150 and 190?C. Radical scavenging activity decrease expressed as trolox equivalent antioxidant capacity (?TEAC, mmol trolox kg-1 oil) is found to be linearly related to increases in total oxidation (?TOTOX) values. This relationship is valid down to a certain - ?TEAC value cutoff that is different for different oils. Considerable consumption of antioxidants demonstrated by high -?TEAC values renders the linear relationship invalid indicating that antioxidants cannot control late events of oxidative damage. Radical scavenging activity is found to increase upon sesame oil heating in contrast to all other oils. It is postulated that sesamolin, a phenolic antioxidant, decomposes during heating to the more potent antioxidant sesamol accounting for the increase of radical scavenging activity upon heating. This paper demonstrates prospects of radical scavenging activity assays as a tool for monitoring oxidation events during frying and warrants further research and evaluation.

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24

Kandalkar, Ankita, Anushka Dinesh, and Sagar Nagare. "Identification of Potent Natural Inhibitor Against Papain Like Protease of SARS CoV 2 an in Silico Approach." Defence Life Science Journal 8, no. 1 (March 10, 2023): 41–49. http://dx.doi.org/10.14429/dlsj.8.17831.

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One of the most complicated tasks the healthcare system has faced in recent years has been the development of a curative treatment to stop the progression of the SARS CoV-2 virus. No consensus has been reached on a medical cure to slow the virus spread. From this point of view, investigating existing drugs such as SARS-CoV-2 inhibitors is an appropriate technique. With critical involvement in viral replication and host-immune suppression, Papain-like protease (PL-pro) is recognized as a key enzyme target for drug development among other SARS-CoV-2 druggable targets. Phytolignans have a wide range of physiological effects, making them an appealing drug for antiviral study. We used an insilico method to target SARS CoV-2 PL-pro with phytolignans in our investigation. The chemical structures of phytolignans were obtained from PubChem, whereas the protease structure 6WX4was obtained from the Protein Data Bank website. The PyRx software was used for molecular docking.Of all the phytolignans examined, Sesamolin has the greatest binding affinity of -8.4 kcal/mol towards PL-pro.The docking results revealed that phytolignans are potent inhibitors of the SARS-CoV-2 papain-like protease and that they may be verified further in vitro and in vivo. Our findings suggest that Sesamolin might be used as a medication to block the action of SARS CoV-2 PL-pro.

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25

Kim, A.-Young, Choong-In Yun, Joon-Goo Lee, and Young-Jun Kim. "Determination and Daily Intake Estimation of Lignans in Sesame Seeds and Sesame Oil Products in Korea." Foods 9, no. 4 (March 30, 2020): 394. http://dx.doi.org/10.3390/foods9040394.

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Sesame (Sesamum indicum L.) is a plant that belongs to the Pedaliaceae family which was first classified as a food source around 4000 years ago. Lignans (sesamin, sesamolin, sesamol, and sesaminol) present in sesame are the primary functional compounds that impart important health benefits. However, very little information is available on the lignan intake from sesame seeds and sesame oil products. Sesame oil is frequently and highly consumed in Korea and therefore is one of the important lignan intake sources due to the food eating habits of Koreans. Herein, we studied the distribution of lignans in sesame seeds (n = 21) and oil (n = 34) to estimate the daily lignan intake by the Korean population. High-performance liquid chromatography, in conjunction with statistical analysis, was used to determine the lignan content of seeds and oil. The estimated daily intake of total lignans from sesame seeds and oil, as estimated from the available domestic consumption data (Korea Nutrition and Health Examination Survey), is 18.39 mg/person/day for males and 13.26 mg/person/day for females. The contributions of lignan intake from sesame seeds and oil are 23.0% and 77.0%, respectively. This study provides preliminary information on lignan intake from sesame seeds and oil in the Korean population.

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Muangrat, Rattana, Yongyut Chalermchart, Supachet Pannasai, and Sukhuntha Osiriphun. "Effect of Roasting and Vacuum Microwave Treatments on Physicochemical and Antioxidant Properties of Oil Extracted from Black Sesame Seeds." Current Research in Nutrition and Food Science Journal 8, no. 3 (December 28, 2020): 798–814. http://dx.doi.org/10.12944/crnfsj.8.3.12.

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Unroasted, roasted (at roasting temperatures of 100, 150 and 200 C and roasting times of 10, 20 and 30 min) and vacuum microwaved (at microwave watt powers of 800, 1440, 2400 and 3600 watts/kg black sesame seeds, for heating times of 10, 20 and 30 min) black sesame seeds were processed to extract oil using a single screw press at a constant pressing temperature of 50 C. The results revealed that different heat pre-treatments significantly affected yield and physiochemical and antioxidant properties of extracted oils. The extracted oil samples exhibited significantly different levels of total phenolic compounds, sesamin, sesamolin, and DPPH• and ABTS•+ scavenging activity. Additionally, it was found that these values of roasted and vacuum microwaved black sesame seed oils were significantly higher than those of unroasted oil. Sesamin, sesamolin, total content of phenolic compounds, and DPPH• and ABTS•+ scavenging activity of extracted black sesame oils increased when the roasting temperature and watt power increased. Black sesame oil obtained from unroasted, roasted and vacuum microwaved dried black sesame seeds contained linoleic and oleic acids as major fatty acids. Black sesame oil extracted from roasting and vacuum microwave treatments for 10 min at higher roasting temperature and microwave watt power had higher total phenolic content leading to a reduction of peroxide value and elevated stability of soybean oil when it was added during storage time at temperature of 65 °C.

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27

NAGATA, Masayasu, Toshihiko OSAWA, Mitsuo NAMIKI, Yasuko FUKUDA, and Tatsuhiko OZAKI. "Stereochemical structures of antioxidative bisepoxylignans, sesaminol and its isomers, transformed from sesamolin." Agricultural and Biological Chemistry 51, no. 5 (1987): 1285–89. http://dx.doi.org/10.1271/bbb1961.51.1285.

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Nagata, Masayasu, Toshihiko Osawa, Mitsuo Namiki, Yasuko Fukuda, and Tatsuhiko Ozaki. "Stereochemical Structures of Antioxidative Bisepoxylignans, Sesaminol and Its Isomers, Transformed from Sesamolin." Agricultural and Biological Chemistry 51, no. 5 (May 1987): 1285–89. http://dx.doi.org/10.1080/00021369.1987.10868187.

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29

Liang, Ming-Tsai, Ru-Chien Liang, Li-Rong Huang, Ping-Hsuan Hsu, Yu-Hsuan Wu, and Hung-En Yen. "Separation of Sesamin and Sesamolin by a Supercritical Fluid-Simulated Moving Bed." American Journal of Analytical Chemistry 03, no. 12 (2012): 931–38. http://dx.doi.org/10.4236/ajac.2012.312a123.

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30

Keowkase, Roongpetch, Natthawut Shoomarom, Worawee Bunargin, Worapan Sitthithaworn, and Natthida Weerapreeyakul. "Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans." Biomedicine & Pharmacotherapy 107 (November 2018): 656–64. http://dx.doi.org/10.1016/j.biopha.2018.08.037.

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31

Hou, Rolis Chien-Wei, Hsueh-Meei Huang, Jason T. C. Tzen, and Kee-Ching G. Jeng. "Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells." Journal of Neuroscience Research 74, no. 1 (September 11, 2003): 123–33. http://dx.doi.org/10.1002/jnr.10749.

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32

Huang, Jinian, Guohui Song, Lixia Zhang, Qiang Sun, and Xin Lu. "A novel conversion of sesamolin to sesaminol by acidic cation exchange resin." European Journal of Lipid Science and Technology 114, no. 7 (March 5, 2012): 842–48. http://dx.doi.org/10.1002/ejlt.201100247.

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33

Shin, Bo Ram, Hye-Won Song, Joon-Goo Lee, Hae-Jung Yoon, Myung-Sub Chung, and Young-Suk Kim. "Comparison of the contents of benzo(a)pyrene, sesamol and sesamolin, and volatiles in sesame oils according to origins of sesame seeds." Applied Biological Chemistry 59, no. 1 (January 29, 2016): 129–41. http://dx.doi.org/10.1007/s13765-015-0138-3.

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34

Takahashi, Miki, Yuzo Nishizaki, Koji Morimoto, Naoki Sugimoto, Kyoko Sato, and Koichi Inoue. "Design of synthetic single reference standards for the simultaneous determination of sesamin, sesamolin, episesamin, and sesamol by HPLC using relative molar sensitivity." Separation Science Plus 1, no. 7 (July 2018): 498–505. http://dx.doi.org/10.1002/sscp.201800081.

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35

OZAYDİN, Dilan, and Pınar KURU BEKTAŞOĞLU. "Travmatik Beyin Hasarı Sıçan Modelinde Sesamol’ün İkincil Yaralanmaya Karşı Koruyucu Etkileri." Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 25, no. 1 (April 30, 2023): 136–42. http://dx.doi.org/10.24938/kutfd.1262700.

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Amaç: Sesamol güçlü bir antioksidan, antiinflammatuar, antiapoptotik ve nöroprotektif bir kimyasaldır. Bu çalışmada, sesamolün sıçan travmatik beyin hasarı (TBH) modelinde histopatolojik etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Otuz iki erkek sıçan dört gruba ayrıldı: kontrol, travma, sham ve sesamol. Travma, sham ve sesamol gruplarına ağırlık düşme yöntemi ile kapalı kafa travması uygulandı, travmadan hemen sonra sırasıyla sham ve sesamol gruplarına periton içine salin ve sesamol (100 mg/kg) uygulandı. Travmadan 24 saat sonra, beyin örnekleri alındı ve elektron ve ışık mikroskobu kullanılarak beyin korteksi histomorfolojik olarak incelendi. Bulgular: Histopatolojik değerlendirme sonucunda sesamol grubunda kafa travması ile indüklenen beyin korteksindeki hasar travma ve sham gruplarından daha azdı. Travma grubuna göre sesamol grubunda perivasküler alan ödemi daha azdı. Sesamol grubunun nöronal uzantılarında da daha az hücre içi ödem ve vakuoller izlendi. Sonuç: Bu çalışmanın sonuçları sesamolün TBH'na karşı nöroprotektif etkiler gösterdiğini ortaya koymuştur.

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36

Fukuda, Yasuko, Minoru Isobe, Masayasu Nagata, Toshihiko Owaea, and Mitsuo Namiki. "Acidic Transformation of Sesamolin, the Sesami-oil Constituent, into an Antioxidant Bisepoxylignan, Sesaminol." HETEROCYCLES 24, no. 4 (1986): 923. http://dx.doi.org/10.3987/r-1986-04-0923.

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37

Tsai, Hsin-Ya, Wei-Ju Lee, I.-Hsuan Chu, Wei-Ching Hung, and Nan-Wei Su. "Formation of Samin Diastereomers by Acid-Catalyzed Transformation of Sesamolin with Hydrogen Peroxide." Journal of Agricultural and Food Chemistry 68, no. 23 (May 12, 2020): 6430–38. http://dx.doi.org/10.1021/acs.jafc.0c01616.

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38

AMAROWICZ, R., F. SHAHIDI, and R. B. PEGG. "APPLICATION OF SEMIPREPARATIVE RP-18 HPLC FOR THE PURIFICATION OF SESAMIN AND SESAMOLIN." Journal of Food Lipids 8, no. 2 (June 2001): 85–94. http://dx.doi.org/10.1111/j.1745-4522.2001.tb00186.x.

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39

Lee, Jae Kwon. "Sesamolin promotes cytolysis and migration activity of natural killer cells via dendritic cells." Archives of Pharmacal Research 43, no. 4 (April 2020): 462–74. http://dx.doi.org/10.1007/s12272-020-01229-y.

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40

Dehkordi, Farshad Roghani, and Mehrdad Roghani. "Mechanisms Underlying Sesamolin-Induced Attenuation of Vascular Dysfunction in Rats With Streptozotocin-Induced Diabetes." International Journal of Endocrinology & Metabolism 9, no. 2 (January 8, 2012): 311–16. http://dx.doi.org/10.5812/kowsar.1726913x.2380.

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FUKUDA, Yasuko, Toshihiko OSAWA, Shunro KAWAGISHI, and Mitsuo NAMIKI. "Comparison of contents of sesamolin and lignan antioxidants in sesame seeds cultivated in Japan." NIPPON SHOKUHIN KOGYO GAKKAISHI 35, no. 7 (1988): 483–86. http://dx.doi.org/10.3136/nskkk1962.35.7_483.

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42

Chandrasekaran, Victor Raj Mohan, Se-Ping Chien, Dur-Zong Hsu, and Ming-Yie Liu. "Anti-hepatotoxic effects of 3,4-methylenedioxyphenol and N-acetylcysteine in acutely acetaminophen-overdosed mice." Human & Experimental Toxicology 30, no. 10 (January 14, 2011): 1609–15. http://dx.doi.org/10.1177/0960327110394226.

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3,4-Methylenedioxyphenol (sesamol) is effective against acetaminophen-induced liver injury in rats. Whether sesamol’s anti-hepatotoxic effect is comparable to that of N-acetylcysteine has never been studied. We investigated the anti-hepatotoxic effects of sesamol and N-acetylcysteine on acetaminophen-induced hepatotoxicity in mice. Equimolar doses (1 mmol/kg) of sesamol and N-acetylcysteine significantly inhibited acetaminophen (300 mg/kg)-increased serum aspartate transaminase and alanine transaminase levels 6 h post-administration. Sesamol and N-acetylcysteine maintained hepatic glutathione levels and inhibited lipid peroxidation. Moreover, the combination of sesamol and N-acetylcysteine antagonistically inhibited sesamol’s protection against acetaminophen-induced liver injury. We conclude that the protective effect of sesamol against acetaminophen-induced liver damage is comparable to that of N-acetylcysteine by maintaining glutathione levels and inhibiting lipid peroxidation in mice.

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Zhang, Yongqing, Jiaojiao Wang, Huihui Tan, Xinyue Lu, Deguo Wang, and Quanzeng Wei. "Evaluation of Steaming and Drying of Black Sesame Seeds for Nine Cycles Using Grey-Correlation Analysis Based on Variation-Coefficient Weight." Molecules 28, no. 13 (July 7, 2023): 5266. http://dx.doi.org/10.3390/molecules28135266.

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This study aimed to improve the steaming process of black sesame seeds. A comprehensive evaluation was conducted using the grey-correlation method based on the variation-coefficient weight to observe the treatments of normal-pressure (NPS) and high-pressure (HPS) steaming (with/without soaking in water) for nine cycles. Their effects on the contents of water, protein, fat, ash, melanin, sesamin, and sesamolin of black sesame seeds, as well as the sensory score of the black sesame pill, were determined. We found that with varied steaming methods and increased steaming cycles, the contents of the nutritional and functional components of black sesame seeds and the sensory score of the black sesame pill differed. The results of the variation-coefficient method showed that water, protein, fat, ash, melanin, sesamin, sesamolin, and sensory score had different effects on the quality of black sesame seeds with weighting factors of 34.4%, 5.3%, 12.5%, 11.3%, 13.9%, 11.3%, 7.8%, and 3.5%, respectively. The results of two-factor analysis of variance without repeated observations indicated that the grey-correlation degree of HPS was the largest among the different steaming treatments, and the following sequence was HPS after soaking in water (SNPS), NPS, and SNPS. There was no significant difference between NPS and SNPS (p < 0.05). Moreover, with increased cycles, the value of the grey-correlation degree increased. The comprehensive score of the procedure repeated nine times was significantly higher than other cycles (p < 0.05). The results of the grey-correlation degree and grade analysis showed that the best steaming process of black sesame seeds was HPS for nine cycles, followed by HPS for eight cycles and NPS after soaking in water (SNPS) for nine cycles. These findings could provide a scientific basis for replacing SNPS with HPS to simplify steaming and realize the parametric steaming of black sesame seeds, and thus, ensure the quality of black-sesame products.

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Takano, Seiichi, Takehiko Ohkawa, Shun'ichi Tamori, Shigeki Satoh, and Kunio Ogasawara. "Enantio-controlled route to the furofuran lignans: the total synthesis of (–)-sesamolin, (–)-sesamin, and (–)-acuminatolide." J. Chem. Soc., Chem. Commun., no. 3 (1988): 189–91. http://dx.doi.org/10.1039/c39880000189.

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45

Hou, Rolis Chien-Wei, Chia-Chuan Wu, Chia-Hung Yang, and Kee-Ching G. Jeng. "Protective effects of sesamin and sesamolin on murine BV-2 microglia cell line under hypoxia." Neuroscience Letters 367, no. 1 (August 2004): 10–13. http://dx.doi.org/10.1016/j.neulet.2004.05.073.

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46

Wang, Linhai, Yanxin Zhang, Peiwu Li, Xuefang Wang, Wen Zhang, Wenliang Wei, and Xiurong Zhang. "HPLC Analysis of Seed Sesamin and Sesamolin Variation in a Sesame Germplasm Collection in China." Journal of the American Oil Chemists' Society 89, no. 6 (January 14, 2012): 1011–20. http://dx.doi.org/10.1007/s11746-011-2005-7.

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47

Kalyna, Viktoriia, Serhii Stankevych, Inna Zabrodina, Lidiia Shubina, Maryna Chuiko, Oksana Mikheeva, Viktoriia Horiainova, Denys Shapovalenko, Larysa Obolentseva, and Andrii Kariyk. "Development of the composition of anoxidation-stable dressing with high nutritional value." Eastern-European Journal of Enterprise Technologies 1, no. 11 (127) (February 28, 2024): 29–37. http://dx.doi.org/10.15587/1729-4061.2024.296621.

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The solution to the problem of developing an oxidation-stable dressing with high nutritional value based on unrefined first cold-pressed linseed, corn and sesame oils is considered. The objects of the study are the following indicators: antioxidant, fatty acid composition, induction period of accelerated oxidation of oils, blends and finished products. The rational range of oilratios in the blend, enriched with a-linolenic acid, stabilized against oxidative spoilage due to natural antioxidants – tocopherols, sesamol, sesamolin, is substantiated. The ratio of linseed, corn and sesame oils is 1:2:1, respectively. The characteristics of the blend are as follows: the ratio of ω-3:ω-6 fatty acids is 1:1.7; the induction period of accelerated oxidation (at 80 °C) – 4.1 h. A model sample of the dressing was produced using the developed blend. It was proven that the sample of the dressing of the proposed composition retains its organoleptic and physico-chemical parameters (titratable acidity, dry matter content, acid and peroxide values of the oil fraction) during 30 days of storage at a temperature of 8±1 °C. A feature of the obtained results is the possibility of increasing the nutritional value of the dressing based on unrefined oils while preserving the extended shelf life of products. From a practical point of view, the development of such products allows expanding the range of competitive dressings with high nutritional value. An applied aspect of using the obtained scientific result is the possibility of modeling the composition of dressings or other oil products based on valuable oil raw materials, depending on the ratios of the oil base components of the product

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Huang, Liumin, Jun Li, Yanlan Bi, Yanhui Xu, Yanmei Wang, Jian Wang, and Dan Peng. "Simultaneous determination of α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, sesamin, sesamolin, sesamol, and asarinin in sesame oil by normal-phase high performance liquid chromatography." Journal of Food Composition and Analysis 104 (December 2021): 104132. http://dx.doi.org/10.1016/j.jfca.2021.104132.

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Plaitho, Yossaporn, Pawaweena Rattanasena, Pittaya Chaikham, and Pattaneeya Prangthip. "Biochemical and Antioxidative Properties of Unprocessed and Sterilized White and Black Sesame By-product from Northern Thailand." Current Research in Nutrition and Food Science Journal 5, no. 3 (November 30, 2017): 196–205. http://dx.doi.org/10.12944/crnfsj.5.3.03.

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The objectives of this research were to determine the effects of sterilization on storage stability of white and black sesame by-products. Results showed that sterilization at 120 ºC for 10 min had no effect on proximate compositions and mineral contents of both sesame seed cakes, but the significant reductions of thiamine, riboflavin, sesamin, sesamolin, total phenolic compounds and antioxidant capacity (DPPH and FRAP assays) were observed. During the storage at 37 ºC, all bioactive components and antioxidant properties apparently tended to decrease when the storage time rose. At the end of storage, PV (peroxide value) and TBARS (thiobarbituric acid-reactive substances) values of stored black sesame seed cakes were shown to be significantly lower than that in white sesame seed cakes. This study may suggest the application of black and white sesame seeds cakes as functional food ingredients in the future production.

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Ogata, Naoki, and Masako Kato. "alf-Diallel Analysis for Sesamin and Sesamolin Contents of Sesame (Sesamum indicum L.) Seeds." Japanese journal of crop science 85, no. 3 (2016): 302–8. http://dx.doi.org/10.1626/jcs.85.302.

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