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Academic literature on the topic 'Sentinel lymph node concept'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Sentinel lymph node concept"

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Hertel, Hermann. "Cervical Cancer and the Role of Lymph Node Staging Cons Sentinel Concept." International Journal of Gynecologic Cancer 20, Suppl 2 (September 2010): S37—S38. http://dx.doi.org/10.1111/igc.0b013e3181f7f52b.

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Objective:To determine whether the current standard of cervical cancer staging is sentinel lymph node biopsy.Method:Review of the literature focusing on the significance of the sentinel node concept in patients with cervical cancer. Because of the data on the significance of the intraoperative histopathological assessment of sentinel lymph nodes, the role of micrometastasis in lymph nodes, and the standards of procedure, the sentinel procedure were analyzed.Result:Sentinel lymph node biopsy alone is currently not a routine procedure for cervical cancer staging. This procedure should be performed only by specialized centers in a study setting. More data on its oncological safety are needed.
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Karachun, Aleksey, Aleksey Belyaev, Yuriy Pelipas, D. Asadchaya, Oleg Tkachenko, Marina Grinkevich, Aleksandra Sidorova, and Yuriy Petrik. "A LOOK AT THE NAVIGATION SURGERY OF THE GASTRIC CANCER: THE PRESENT STATE OF THE PROBLEM AND OWN EXPERIENCE." Problems in oncology 65, no. 6 (June 1, 2019): 838–49. http://dx.doi.org/10.37469/0507-3758-2019-65-6-838-849.

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Introduction: Concept of sentinel lymph node biopsy has been discussed during several last decades, because this idea seems perspective in terms of modern minimally invasive and organ-preserving era. However, this method has several limitations including complicated anatomy of gastric lymph nodes distribution and presence of skip-metastases. Materials and methods: 66 Patients with early gastric cancer, intermediate risk of lymph node metastases and technical possibility of ESD were included into our investigation. Patients were assigned to either ESD with sentinel lymph node biopsy (54 patients), or underwent distal gastrectomy or total gastrectomy with D1+/D2 lymphadenectomy (12 patients) by chance. Results: 56 (84,6%) Patients had at least one sentinel lymph node. 11 (16,7%) Patients with T1a-T1b had metastases in regional lymph nodes, 9 of them in sentinel lymph nodes (2 false-negative result). So, we calculated sensitivity of 84,6%. In one case, the metastasis was located outside the sentinel lymphatic basin, and in the other case, metastasis was detected in a patient with unlit lymph nodes. Conclusion: Today sentinel lymph node biopsy thechnique is considered as a well investigated and widly used method. The concept itself is promising for organ-preserving gastric cancer surgery.
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Pizzocaro, Claudio, Pier Luigi Rossini, Arturo Terzi, Roberto Farfaglia, Laura Lazzari, Edda Simoncini, and Raffaele Giubbini. "Sentinel Node Biopsy in Breast Cancer: The Experience of Brescia Civic Hospital." Tumori Journal 86, no. 4 (July 2000): 309–11. http://dx.doi.org/10.1177/030089160008600412.

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The accuracy of the sentinel node technique in the evaluation of axillary node involvement in breast cancer was evaluated in 83 consecutive patients with monofocal T1–2 carcinoma, who were clinically N0 and who underwent lymphoscintigraphy with 99mTc-colloid integrated with intraoperative sentinel node detection by a portable probe. Lymphoscintigraphy revealed at least one sentinel node in 75 patients (90.4%), always identified by the probe. In eight patients (9.6%) the sentinel node was detected neither by lymphoscintigraphy nor by the probe. All removed lymph nodes were analyzed by hematoxylin-eosin histology and the sentinel node by immunostaining. In 28/75 patients (37.3%) at least one metastatic axillary lymph node was detected; in 16 of the 28 N+ subjects (57%) only the sentinel node was positive. The false negative rate (sentinel node negative/other axillary lymph nodes positive) was 17.85% (5/28 patients). In 9/23 patients (39%) micrometastases were found in the sentinel node only. In conclusion, specific sentinel node positivity in 57% of cases supports the validity of the sentinel node concept. Moreover, nine patients would have been considered No by standard hematoxylin-eosin histology without sentinel node-aided immunostaining. A 17.8% false negative rate calls for caution in patients with negative sentinel nodes.
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Liberale, Gabriel, Sophie Vankerckhove, Fikri Bouazza, Maria Gomez Galdon, Denis Larsimont, Michel Moreau, Pierre Bourgeois, and Vincent Donckier. "Systemic Sentinel Lymph Node Detection Using Fluorescence Imaging After Indocyanine Green Intravenous Injection in Colorectal Cancer: Protocol for a Feasibility Study." JMIR Research Protocols 9, no. 8 (August 14, 2020): e17976. http://dx.doi.org/10.2196/17976.

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Background Nodal staging is a major concern in colorectal cancer as it is an important prognostic factor. Several techniques that could potentially improve patient treatment and prognosis have been developed to increase the accuracy of nodal staging. Sentinel lymph node detection has been shown to accurately reflect nodal status in various tumors and has become the standard procedure in nodal staging of breast cancer and melanoma. However, in colorectal cancer, sentinel lymph node detection techniques are still controversial as the sensitivity reported in the literature varies from one study to another. Recently, indocyanine green fluorescence–guided surgery has been reported to be a useful technique for detection of macroscopic and microscopic metastatic deposits in lymph nodes after intravenous administration of indocyanine green dye. However, no studies have focused on the potential role of sentinel lymph node detection after systemic administration of indocyanine green dye, so-called systemic sentinel lymph nodes, or on the correspondence between the identification of the sentinel lymph node by standard local injection techniques and the detection of fluorescent lymph nodes with this new approach. Objective The aim of this protocol is to validate the concept of sentinel lymph nodes identified by fluorescence imaging after intravenous injection of indocyanine green dye and to compare the sentinel lymph nodes identified by fluorescence imaging with sentinel lymph nodes detected by the standard blue dye technique. Methods This study (SeLyNoFI; Sentinel Lymph Nodes Fluorescence Imaging) is a diagnostic, single-arm, open-label feasibility study, including patients with colorectal adenocarcinoma with or without metastatic disease who are admitted for elective colorectal resection of the primary tumor. This study evaluates the feasibility of a new approach for improving the accuracy of nodal staging using fluorescence imaging after intravenous administration of indocyanine green dye. Sensitivity, positive predictive value, and accuracy of the classical blue dye technique and of the investigatory fluorescence imaging technique will be calculated. Translational research will be proposed, if applicable. Results As of June 2020, this study has been registered. Submission for ethical review is planned for September 2020. Conclusions The potential correlation between the two different approaches to detect sentinel lymph nodes offers new strategies for improving the accuracy of nodal staging in colorectal cancer. This new concept of the systemic sentinel lymph node and a greater understanding of the interactions between systemic sentinel lymph nodes and standard sentinel lymph nodes may provide important information regarding the underlying mechanism of primary tumor lymphatic drainage. The enhanced permeability and retention effect can also play a role in the fluorescence of systemic sentinel lymph nodes, especially if these lymph nodes are inflamed. In this case, we can even imagine that this new technique will highlight more instances of lymph node–positive colorectal cancer. International Registered Report Identifier (IRRID) PRR1-10.2196/17976
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Milulescu, Amelia, Cristian Gabriel Viisoreanu, Nicolae Bacalbasa, Irina Balescu, Tiberiu-Augustin Georgescu, Corina Grigoriu, Costin Berceanu, and Roxana Elena Bohiltea. "Management of the axilla: Conventional tracers vs ICG-fluorescence in sentinel lymph node biopsy." Romanian Medical Journal 68, S6 (December 30, 2021): 126–28. http://dx.doi.org/10.37897/rmj.2021.s6.21.

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The evaluation of regional lymph nodes is part of breast cancer staging. Biopsy of the sentinel lymph node was established, in order to evaluate the condition of the axillary lymph nodes without having to complete an axillary dissection. The concept of sentinel lymph node (SLN) is based on the theory of sequential dissemination of tumor cells through the lymph. When lymphatic dissemination occurs, the invasion initially occurs in the first lymph node that drains lymph from the tumor. This lymph node has been named GS and depending on its negative or positive status, the presence or absence of metastases in the remaining regional lymph nodes can be established. Blue dye (BD) and radioactive isotopes (RI) are routinely used markers for identification of the sentinel lymph nodes during sentinel lymph node biopsy (SLNB) in early stage breast cancer. Unlike the blue dye technique, using radioactive isotopes has lower false-negative rates. Nonetheless, the need of lymphoscintigraphy, the time needed for preoperative injection, and undetected sentinel lymph nodes in some cases cause surgeons to rely only on the combination of blue dye and radioisotopes. At present, indocyanine green (ICG) fluorescence method (ICG-SLNB) is starting to gain more and more field as an alternative to conventional mapping methods. The purpose of this review is to compare ICG with the conventional methods (blue dye and radioactive isotopes) and their role in detection of SLN.
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HASEGAWA, Shogo, Ken OMURA, Hiroyuki HARADA, Hiroaki SHIMAMOTO, Yoshihiko YOSHIDA, Masaru UEKUSA, and Takashi TOGAWA. "SENTINEL LYMPH NODE CONCEPT IN ORAL CANCER." Toukeibu Gan 31, no. 4 (2005): 517–22. http://dx.doi.org/10.5981/jjhnc.31.517.

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Karachun, Aleksey, Yuriy Pelipas, Oleg Tkachenko, and D. Asadchaya. "BIOPSY OF THE SIGNALING LYMPH NODES IN GASTRIC CANCER - CURRENT STATUS OF THE PROBLEM AND PROSPECTS." Problems in oncology 64, no. 3 (March 1, 2018): 335–44. http://dx.doi.org/10.37469/0507-3758-2018-64-3-335-344.

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The concept of biopsy of sentinel lymph node as the first lymph node in the pathway of lymphogenous tumor spread has been actively discussed over the past decades and has already taken its rightful place in breast and melanoma surgery. The goal of this method is to exclude vain lymphadenectomy in patients without solid tumor metastases in regional lymph nodes. In the era of minimally invasive and organ-saving operations interventions it seems obvious an idea to introduce a biopsy of sentinel lymph node in surgery of early gastric cancer. Meanwhile the complexity of lymphatic system of the stomach and the presence of so-called skip metastases are factors limiting the introduction of a biopsy of sentinel lymph node in stomach cancer. This article presents a systematic analysis of biopsy technology of signaling lymph node as well as its safety and oncological adequacy. Based on literature data it seems to us that the special value of biopsy of sentinel lymph nodes in the future will be in the selection of personalized surgical tactics for stomach cancer.
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Cheng, Li-Yang. "Sentinel lymph node concept in gastric cancer with solitary lymph node metastasis." World Journal of Gastroenterology 10, no. 20 (2004): 3053. http://dx.doi.org/10.3748/wjg.v10.i20.3053.

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Miki, J., T. Yanagisawa, K. Obayashi, K. Sakanaka, T. Matsuura, M. Tanaka, K. Miyajima, et al. "Sentinel lymph node concept in bladder cancer with solitary lymph node metastasis." European Urology Open Science 19 (July 2020): e1519. http://dx.doi.org/10.1016/s2666-1683(20)33609-0.

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Cecchi, Roberto, Cataldo De Gaudio, Lauro Buralli, and Stefania Innocenti. "Lymphatic Mapping and Sentinel Lymph Node Biopsy in the Management of Primary Cutaneous Melanoma: Report of a Single-centre Experience." Tumori Journal 92, no. 2 (March 2006): 113–17. http://dx.doi.org/10.1177/030089160609200205.

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Aims and Background Lymphatic mapping and sentinel lymph node biopsy provide important prognostic data in patients with early stage melanoma and are crucial in guiding the management of the tumor. We report our experience with lymphatic mapping and sentinel lymph node biopsy in a group of patients with primary cutaneous melanoma and discuss recent concepts and controversies on its use. Patients and Methods A total of 111 patients with stage I-II AJCC primary cutaneous melanoma underwent lymphatic mapping and sentinel lymph node biopsy from December 1999 through December 2004 using a standardized technique of preoperative lymphoscintigraphy and biopsy guided by blue dye injection in addition to a hand-held gamma probe. After removal, sentinel lymph nodes were submitted to serial sectioning and permanent preparations for histological and immunohistochemical examination. Complete lymph node dissection was performed only in patients with tumor-positive sentinel lymph nodes. Results Sentinel lymph nodes were identified and removed in all patients (detection rate of 100%), and metastases were found in 17 cases (15.3%). The incidence of metastasis in sentinel lymph nodes was 2.1%, 15.9%, 35.2%, and 41.6% for melanomas < or 1.0, 1.01-2.0, 2.01-4.0, and > 4.0 mm in thickness, respectively. Complete lymph node dissection was performed in 15 of 17 patients with positive sentinel lymph nodes, and metastases in non-sentinel lymph nodes were detected in only 2 cases (11.7%). Recurrences were more frequently observed in patients with a positive than in those with negative sentinel lymph node (41.1% vs 5.3% at a median follow-up of 31.5 months, P<0.001). The false-negative rate was 2.1%. Conclusions Our study confirms that lymphatic mapping and sentinel lymph node biopsy allow accurate staging and yield relevant prognostic information in patients with early stage melanoma.
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Dissertations / Theses on the topic "Sentinel lymph node concept"

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Richardson, Keith. "Sentinel lymph node biopsy for papillary thyroid cancer." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114194.

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Objective: To prospectively evaluate the role of sentinel lymph node (SLN) biopsy in the management of well differentiated thyroid carcinoma (WDTC)Methods: I designed and implemented a SLN biopsy protocol and subsequently performed it on consecutive patients undergoing thyroid surgery. Thyroid nodules were injected with methylene blue dye. A central compartment neck dissection (CCND) was performed. Frozen section analysis of the SLNs was performed.Results: 157 patients are included in this study. 94 patients had WDTC. Sevently three percent (69/94) of WDTC patients were found to have detectable SLNs. Twenty percent (14/69) of patients with SLNs were found to have central compartment metastases. The sensitivity, specificity, positive predictive value and negative predictive value of our SLN biopsy technique to remove all disease from the central compartment was 92.9%, 100%, 100% and 98.8% respectively (p < 0.0001). Conclusion: This data series suggests that if a patient has SLNs deemed as negative for malignancy on frozen section, the rest of the central compartment is unlikely to have lymph node metastasis.
Contexte: Notre objectif est d'évaluer prospectivement le rôle du biopsy ganglion sentinelle dans la gestion du cancer de la thyroïde bien différencié Méthodes: Nous avons conçu et mis en place un protocole de biopsie du ganglion sentinelle et par la suite effectuées notre protocol sur des patients consécutifs subissant une thyroïdectomie. Les nodules ont été injectés avec du bleu de méthylène. Un dissection du cou central a été effectuée. Examen intra-operatoire des ganglion a été réalisée.Résultats: 157 patients sont inclus dans cette étude. 94 patients avaient un dissection central du cou. 73% (69/94) des patients ont été trouvés à avoir ganglion détectable. 20% (14/69) des patients atteints de ganglion ont été trouvés à avoir des métastases compartiment central. La sensibilité, spécificité, valeur prédictive positive et valeur prédictive négative de notre technique de biopsie du ganglion sentinelle pour enlever toutes les maladies à partir du compartiment central était de 92,9%, 100%, 100% et 98,8% respectivement (p <0,0001).Conclusion: Cette série de données volumineux suggère que si un patient a jugé comme négatif intra-operatoire de malignité sur la section gelée, un dissection central peut être preventire.
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Wahed, Shajahan. "Minimally invasive sentinel lymph node biopsy in oesophageal adenocarcinoma." Thesis, University of Newcastle upon Tyne, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.720011.

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Introduction and Aims Sentinel lymph nodes are the first nodes draining a primary tumour and the most likely sites of early metastases. A minimally invasive technique of identifying sentinel nodes in oesophageal adenocarcinoma could revolutionise management by determining whether patients with submucosal disease can be treated solely by endoscopic resection and whether other patients are suitable for a less radical lymphadenectomy. We evaluated a laparoscopic technique of identifying abdominal sentinel lymph nodes in patients with oesophageal adenocarcinoma and assessed whether these nodes could predict overall lymph node status. Methods This trial recruited patients with lower-third oesophageal adenocarcinoma planned for two-stage oesophagectomy with two-field lymphadenectomy. Sentinel node identification occurred immediately before resection, following endoscopic submucosal injection of 99mTechnetium-nanocol!oid. A laparoscopic gamma probe measured radioactivity from all nodal stations at laparoscopy, from the open abdomen, from the mediastinum following thoracotomy and ex vivo following removal of the specimen. Sentinel nodes had in vivo radioactivity greater than twice and ex vivo greater than 10 times background. Specimens were examined using haematoxylin and eosin and immunohistochemistry. Results A total of 1297 lymph nodes were examined from 40 patients (median 31 nodes). The median age and BMI were 65.5years and 26.5kg/m2 re s pectively. The overall sentinel node detection rate was 85% and sensitivity 88%. The laparoscopic abdominal sentinel node detection rate was 58% (23/40). Lymph node metastases were identified in 13 of these 23 patients, in whom laparoscopic abdominal sentinel nodes were positive in 10 but negative in three (sensitivity 77%). Two of these negative patients had mediastinal sentinel node micrometastases. Eleven patients had only mediastinal sentinel nodes. Five patients had no sentinel nodes. Adhesions prevented laparoscopy in one patient. Conclusions Laparoscopic identification of abdominal sentinel lymph using 99mTechnetium in patients with oesophageal adenocarcinoma was safe and technically feasible but not sensitive enough to predict overall nodal status.
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Doting, Meintje Hylkje Edwina. "Sentinel lymph node biopsy in breast cancer and melanoma." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/300326254.

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Korowlay, Nisaar Ahmed. "The use of lymphoscintigraphy to localise the sentinel lymph node." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/2802.

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Includes bibliographical references (leaves 72-90).
Sentinel lymph node (SLN) biopsy is being used increasingly for staging early breast carcinoma in place of complete axillary lymph node dissection. The optimal method to identify the SLN and has not been clearly elucidated in the literature. A number of techniques have been proposed for identifying SLN/s. The main debate centres on whether to use a blue dye or radiopharmaceutical method either singly or in combination.
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Karlsson, Mona. "Sentinel node based immunotherapy of cancer /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-203-3/.

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Johnson, Laura. "Magnetic nanoparticles for sentinel lymph node imaging and biopsy in breast cancer." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/magnetic-nanoparticles-for-sentinel-lymph-node-imaging-and-biopsy-in-breast-cancer(978692de-a495-4df1-ac0f-303227bed0dd).html.

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Background Axillary nodal status is the single most important prognostic factor in breast cancer diagnosis. If cancerous cells are present, the sentinel lymph node (SLN) is the axillary lymph node that is most likely to contain metastatic disease. In early stage breast cancer, the SLN is localised (then surgically removed for pathological analysis) using a radioisotope and/or a blue dye injected into the breast Super-paramagnetic iron oxide (SPIO) nanoparticles are novel agents that, when injected, could potentially both localise and characterise the SLN using MRI such that surgical SLN biopsy is no longer required. Aims To evaluate axillary SLN localisation after SPIO injection with, pre-operatively, axillary MRI and, intra-operatively, with a hand held magnetometer and to characterise SLN SPIO uptake using ex-vivo MRI. Methods From November 2009 - March 2011, 51 patients with early stage breast cancer underwent SLN biopsy following a subcutaneous injection of SPIO in addition to the standard injection of radioisotope (Tc99M) and blue dye. SPIO injection technique was refined during the trial with an initial dose of 2mls and then 4mls in 8 and then 43 women respectively. Pre-operative axillary in vivo MRI (1.5T) was carried out on 14 women and ex vivo high resolution MRI (9.4T) on 36 nodes. During surgery, an SLN was defined as either "hot", "blue", "palpable" or "SPIO detected". Axillary clearance was carried out for SLN-positive disease. Results In total, 11 of the 51 patients had positive SLNs. On pre-operative axillary MRI, SPIO uptake was noted in at least one node in all 14 patients. A total of 35 nodes were identified. Uptake of SPIO in the SLN was seen at a minimum of 12mins post injection. Involved SLNs were not differentiated from normal SLNs following morphological characterisation or based on loss of T2 signal within the individual SLN. At SLN biopsy, 134 hot, blue, palpable or SPIO-containing nodes were identified in 51 patients. The magnometer identified 92 SPIO-containing nodes in 51 (84%) patients. One node in one patient was not identified using the combined technique but was found to contain SPIO. Of the 16 hot, blue or palpable involved nodes in 11 patients, 9 contained SPIO. In summary, the SPIO SLN localisation rate and FNR in patients was 84% and 16% respectively. Ex vivo SLN MRI demonstrated SPIO uptake in all 35 SLNs preferential to the sinuses and sub-capsular spaces. Of the 3 involved nodes, areas of metastasis did not take up SPIO, whereas in normal areas of the node, SPIO was positively identified. Conclusion In our study, subcutaneous SPIO, a novel SLN-localising agent, was taken up by axillary nodes and identified on pre-operative axillary MRI. Node positive SLNs were identified on ex vivo MRI, but SPIO did not demonstrate sufficient accuracy at SLN localisation for routine clinical use.
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O'Sullivan, Jack Denis. "Imaging through a scanner, darkly : spectral imaging for sentinel lymph node biopsies." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/339772/.

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Breast cancer is the single most prevalent form of cancer in the UK today, accounting for around 16% of all diagnoses, and around 31% of diagnoses in women. The survival rates are good, however the prognosis is heavily dependent on the stage to which the cancer has progressed at diagnosis. In order to help accurately determine this stage, the sentinel lymph node of patients undergoing tumour resection surgery is removed and examined cytologically for the presence of cancerous cells. This examination of the lymph node is currently the rate-limiting step in the operation as a whole. There is evidence in the literature to suggest that cancerous tissue has a measurably different infrared spectrum from healthy tissue owing to chemical and morphological differences in the tissue. There is further evidence to suggest that in the visible and near infrared region, the spectra of healthy lymph node tissue is different from that of cancerous tissue. This thesis details a project, performed in collaboration with a surgical team at St Mary's Hospital, Newport, Isle of Wight, to analyse spectral images taken in the visible and near infrared, of biopsied lymph node tissue. In the course of the project, an unsupervised classificaton technique, based on an extension to the well establised 'spectral angle', was developed to analyse the spectral images. Psoriasis affects 2-3% of the UK population causing itchy and/or painful plaques on the skin. One of the main treatments for psoriasis is UV phototherapy, exposure to which is a risk factor for burning and the development of cancers. This thesis details an investigation into the possibility of developing a targeted UV phototherapy system based on spectral imaging to delineate the plaques and a proposed new UV laser for treatment.
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Retter, Steffen Mario [Verfasser]. "Bewertung der Bedeutung des "Sentinel lymph node mapping" beim Kolonkarzinom / Steffen Mario Retter." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2011. http://d-nb.info/1012010228/34.

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Rizvi, S. B. "Semiconductor Quantum Dots as fluorescent probes for cancer localisation and sentinel lymph node biopsy." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1370655/.

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Quantum Dots (QDs) are fluorescent nanoparticles that can be used as fluorescent probes for cancer localisation and sentinel lymph node biopsy (SLNB). The current tracers for SLNB including the blue dye and radiocolloid have various drawbacks limiting their widespread use. Near Infrared (NIR) QDs can potentially replace these tracers, based on their deep tissue visibility as the biological window is transparent to NIR wavelengths. QDs can also be conjugated to specific biomolecules for targeted cancer localisation and therapy. Their main limitation is toxicity as most QDs are based on heavy metal salts. This project aims to develop a biocompatible QD for clinical application using a novel nanoparticle - Polyhedral Oligomeric Silsesquioxane (POSS) based surface coatings. Materials & Methods A novel nanocomposite polymer emulsion POSS-PCU was synthesized by integrating POSS units into poly(carbonate-urea)urethane (PCU) chains and used to encapsulate QDs based on CdTe/CdSe/ZnSe and CdTe/CdS/ZnS. Mercapto-POSS on its own was also used to coat CdTe core QDs. Characterization was performed using various techniques and in vitro toxicity was established. QDs were bioconjugated to anti-HER2 antibody and used to localise HER-2 receptors on SK-BR-3 breast cancer cells. In vivo biodistribution was determined using a tail vein injection of QDs into male Sprague-Dawley rats for 1 and 24h. Organ biodistribution was quantified by fluorescence studies and Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). A live NIR imaging system was set up and NIR-QDs used to demonstrate SLN localisation in a rat model. Results POSS-PCU coated QDs showed significantly reduced toxicity and enhanced photostability on in vitro and in vivo studies. QD-anti-HER2-Antibody bioconjugate successfully localised HER-2 receptors in vitro. Biodistribution studies showed maximal uptake by the liver and spleen. NIR-QDs localised to the SLN and were visualised by the live NIR imaging system. Conclusion NIR-QDs can be used as fluorescent probes for cancer localisation and SLNB. POSS nanocomposite based surface coatings can stabilise QDs for overall reduced toxicity and enhanced photostability allowing relentless possibilities for clinical application.
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Dinh, Kate H. "Sentinel Lymph Node Biopsy in Elderly Patients with Intermediate Thickness Melanoma: A Masters Thesis." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/778.

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Background: A landmark study suggested that wide excision of intermediate-thickness melanoma with sentinel lymph node biopsy (SLNB) and subsequent completion lymph node dissection (CLND) for regional disease may improve prognostication and disease-free survival (DFS) compared with those undergoing wide excision alone. However, these benefits were relatively small and not associated with an improvement in disease-specific survival (DSS). It remains unknown if SLNB and subsequent treatments are beneficial in elderly patients who have a decreased overall (OS) due to other causes. Methods: Adults ≥ 70 years of age, who underwent surgical intervention for intermediate-thickness cutaneous melanoma from 2000-2013 were identified from a prospectively-maintained database. Clinicopathologic variables measured included age, gender, anatomic site, histologic type, tumor thickness, ulceration, receipt and result of SLNB, completion of CLND, OS, and DFS. Results: Ninety-one patients underwent excision of an intermediate-thickness melanoma. Forty-nine patients (54%) received a SLNB. Seven of these biopsies (14%) were positive, and five patients went on to receive CLND. Five-year OS was 41% in patients who did not receive SLNB and 52% in patients who did receive SLNB (p=0.11). DFS was similar between groups independent of receipt of SLNB. Conclusion: Among elderly patients with intermediate-thickness melanoma, patients who received SLNB had similar 5-year OS and DFS compared with those who did not receive SLNB. Routine SLNB for intermediate-thickness melanoma patients may not significantly change outcomes for this age group, and clinical decision-making should consider individual patient comorbidities and goals of care.
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Books on the topic "Sentinel lymph node concept"

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Leong, Stanley P. L. Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer. Cleveland: Kluwer Academic Publishers, 2003.

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Reiser, Maximilian F., Alfred Schauer, Kurt Possinger, and Wolfgang Becker. Sentinel Lymph Node Concept. Springer London, Limited, 2005.

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The sentinel lymph node concept. Berlin: Springer-Verlag Berlin Heidelberg, 2004.

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The Sentinel Lymph Node Concept. Springer, 2004.

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The Sentinel Lymph Node Concept. Berlin/Heidelberg: Springer-Verlag, 2005. http://dx.doi.org/10.1007/b137529.

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International Symposium on "The Sentinel Lymph Node Concept in Oncology" (2000 : Berlin, Germany), ed. The sentinel lymph node concept in oncology: Facts and fiction. München: Zuckschwerdt, 2001.

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Hiram, Cody. Sentinel Lymph Node Biopsy. Taylor & Francis Group, 2001.

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Sentinel Lymph Node Biopsy. London: Taylor & Francis Group Plc, 2004.

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Harrison, Jones undifferentiated, Barry M. Kinzbrunner, Schmidt undifferentiated, Giocobini, Kopelman, Serruys, et al. Sentinel Lymph Node Biopsy. Informa Healthcare, 2001.

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S, Cody Hiram, ed. Sentinel lymph node biopsy. London: Martin Dunitz, 2002.

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Book chapters on the topic "Sentinel lymph node concept"

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Nieweg, Omgo E. "The Sentinel Lymph Node Concept." In Atlas of Lymphoscintigraphy and Sentinel Node Mapping, 143–49. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45296-4_6.

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Cabanas, R. M. "The Concept of the Sentinel Lymph Node." In Recent Results in Cancer Research, 109–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57151-0_9.

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Charalampoudis, Petros, and Christos Markopoulos. "Current Concept of Sentinel Lymph Node Biopsy." In Breast Cancer Essentials, 499–507. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73147-2_44.

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Nieweg, Omgo E. "The Sentinel Lymph Node Concept in Oncologic Surgery." In Atlas of Lymphoscintigraphy and Sentinel Node Mapping, 87–93. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-2766-4_6.

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Orsini, Federica, Federica Guidoccio, Sergi Vidal-Sicart, Renato A. Valdés Olmos, and Giuliano Mariani. "General Concepts on Radioguided Sentinel Lymph Node Biopsy: Preoperative Imaging, Intraoperative Gamma Probe Guidance, Intraoperative Imaging, Multimodality Imaging." In Atlas of Lymphoscintigraphy and Sentinel Node Mapping, 151–69. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45296-4_7.

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Orsini, Federica, Federica Guidoccio, Sergi Vidal-Sicart, Renato A. Valdés Olmos, and Giuliano Mariani. "General Concepts on Radioguided Sentinel Lymph Node Biopsy: Preoperative Imaging, Intraoperative Gamma-Probe Guidance, Intraoperative Imaging, and Multimodality Imaging." In Atlas of Lymphoscintigraphy and Sentinel Node Mapping, 95–110. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-2766-4_7.

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Jensen, Lindsay G., Loren K. Mell, Christin A. Knowlton, Michelle Kolton Mackay, Filip T. Troicki, Jaganmohan Poli, Edward J. Gracely, et al. "Sentinel Lymph Node." In Encyclopedia of Radiation Oncology, 781. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_535.

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Nieweg, Omgo E. "Sentinel Lymph Node." In Encyclopedia of Cancer, 1–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_5242-4.

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Persichetti, Paolo, Stefania Tenna, Beniamino Brunetti, and Stefano Campa. "Sentinel Lymph Node." In Skin Cancer, 487–97. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7357-2_32.

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Clark, Jonathan R., and Douglas Shaw. "Sentinel Lymph Node." In Encyclopedia of Otolaryngology, Head and Neck Surgery, 2407. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-23499-6_200158.

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Conference papers on the topic "Sentinel lymph node concept"

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Jaishuen, Atthapon, Pisutt Srichaikul, and Khemanat Khemworapong. "Sentinel lymph node mapping in endometrial cancer." In The 7th Biennial Meeting of Asian Society of Gynecologic Oncology. Korea: Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology, 2021. http://dx.doi.org/10.3802/jgo.2021.32.s1.e30.

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Reitsamer, R., S. Glueck, C. Menzel, and F. Peintinger. "Non-Sentinel Lymph Node Status of Patients with T1/T2 Breast Cancer and Micrometastasis in the Sentinel Lymph Node." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-1034.

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Huang, J., X. Chen, K. Shen, Y. Li, W. Chen, J. He, L. Zhu, et al. "Abstract P3-01-13: Risk factors of non-sentinel lymph node metastasis in breast cancer patients with metastatic sentinel lymph node." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p3-01-13.

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Liu, Yang, Adam Q. Bauer, Walter Akers, Gail Sudlow, Kexian Liang, Duanwen Shen, Mikhail Berezin, Joseph P. Culver, and Samuel Achilefu. "Compact intraoperative imaging device for sentinel lymph node mapping." In SPIE BiOS, edited by Samuel Achilefu and Ramesh Raghavachari. SPIE, 2011. http://dx.doi.org/10.1117/12.886226.

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Waanders, S., M. Ahmed, B. Anninga, R. M. Ferguson, A. P. Khandhar, S. Kemp, M. Douek, K. M. Krishnan, and B. ten Haken. "SPIO requirements for in vivo sentinel lymph node localization." In 2015 5th International Workshop on Magnetic Particle Imaging (IWMPI). IEEE, 2015. http://dx.doi.org/10.1109/iwmpi.2015.7107000.

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Gur, SA, B. Unal, R. Johnson, G. Ahrendt, M. Bonaventura, and A. Soran. "The predictive probability of four different breast cancer nomograms for non-sentinel axillary lymph node metastasis in positive sentinel lymph node biopsy." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-204.

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Tanaka, S., N. Sato, H. Fujioka, Y. Takahashi, K. Kimura, and M. Iwamoto. "P3-07-35: Validation of Online Calculators To Predict Non-Sentinel Lymph Node Status in Sentinel Lymph Node-Positive Breast Cancer Patients." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p3-07-35.

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Kitamoto, Yoshitaka, Takaaki Masaki, Suko Bagus Trisnanto, Tomoaki Ueda, and Masanori Abe. "Magnetic sensor for sentinel lymph node biopsy using superparamagnetic beads." In 2012 IEEE Sensors. IEEE, 2012. http://dx.doi.org/10.1109/icsens.2012.6411180.

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Arslanagic, R. "Sentinel lymph node biopsy accuracy in PTC neck negative disease." In Abstract- und Posterband – 91. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Welche Qualität macht den Unterschied. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1710932.

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Jouhannaud, J., A. Garofalo, D. Felder-Flesch, and G. Pourroy. "Dendronized iron oxide colloids for imaging the sentinel lymph node." In SPIE BiOS, edited by Wolfgang J. Parak, Marek Osinski, and Xing-Jie Liang. SPIE, 2015. http://dx.doi.org/10.1117/12.2080062.

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Reports on the topic "Sentinel lymph node concept"

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Sutton, Richard. Sentinel Lymph Node Biopsy. Touch Surgery Simulations, October 2014. http://dx.doi.org/10.18556/touchsurgery/2014.s0033.

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Goodwin, Andrew P. Multifunctional Polymer Microbubbles for Advanced Sentinel Lymph Node Imaging and Mapping. Fort Belvoir, VA: Defense Technical Information Center, June 2012. http://dx.doi.org/10.21236/ada583372.

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Goodwin, Andrew P. Multifunctional Polymer Microbubbles for Advanced Sentinel Lymph Node Imaging and Mapping. Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada591061.

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Hassett, Mary. Outcomes by Ethnicity: Sentinel Lymph Node Status in Women with Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, April 2007. http://dx.doi.org/10.21236/ada495304.

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Cavalli, Luciane R. Detection of Genetic Alterations in Breast Sentinel Lymph Node by Array-CGH. Fort Belvoir, VA: Defense Technical Information Center, October 2005. http://dx.doi.org/10.21236/ada444833.

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Cavalli, Luciane R. Detection of Genetic Alterations in Breast Sentinel Lymph Node by Array-CGH. Fort Belvoir, VA: Defense Technical Information Center, October 2006. http://dx.doi.org/10.21236/ada460808.

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Wang, Shi-Yi, Peiyin Hung, Brigid Killelea, Sarah Mougalian, Suzanne Evans, Tannaz Sedghi, and Cary Gross. Comparing Treatment for Ductal Carcinoma In Situ (DCIS) With or Without Sentinel Lymph Node Biopsy. Patient-Centered Outcomes Research Institute® (PCORI), July 2020. http://dx.doi.org/10.25302/06.2020.cer.150731630.

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Wen, Zhenhua. Efficacy of sentinel lymph node biopsy versus standard axillary care for operable breast cancer: a systematic-review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0032.

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Liu, Hongjin, Mingshuai Sun, Liyuan Liu, Zhengheng Yu, Qian Liu, Yuanjia Cheng, Ling Xu, Yinhua Liu, and Jingming Ye. The Using of Methylene Blue Dye combined with Other Tracer in Sentinel Lymph Node Biopsy of Early Breast Cancer: A Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2021. http://dx.doi.org/10.37766/inplasy2021.5.0107.

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Cao, Siyang, Xia Liu, Zijian Yang, Xiaoling Liu, hui Hu, Yibing Hu, and Wei Wei. Feasibility of sentinel lymph node biopsy in breast cancer patients with positive axillary nodes at initial diagnosis after neoadjuvant chemotherapy: An updated meta-analysis involving 3,450 patients. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2020. http://dx.doi.org/10.37766/inplasy2020.11.0019.

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