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Dissertations / Theses on the topic 'Self-therapy'

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Published: 4 June 2021
Last updated: 8 February 2022

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1

Reupert, Andrea E., and areupert@csu edu au. "The Counsellor's Self in Therapy." La Trobe University. School of Educational Studies, 2004. http://www.lib.latrobe.edu.au./thesis/public/adt-LTU20050404.161132.

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The person of the counsellor, or what is sometimes referred to as the counsellor�s self, is the focus of this thesis. How the counsellor�s self is described and manifested during therapy constitute the two main research questions. Various perspectives are presented from psychoanalysis, behaviour therapy, cognitive behaviour therapy, person centered therapy and systems therapy. While issues pertaining to the counsellor�s self have been explored predominately by systems therapists, this study extends previous research by involving interviews with counsellors from a range of orientations. The study is conducted within an interpretative research paradigm, and data are collected and interpreted according to a qualitative approach. Semi-structured interviews with 16 counsellors, from a range of theoretical orientations, constitute the primary method of data collection. Other data sources include a short questionnaire sent to the same counsellors, the researcher�s reflective journal as well as recorded meetings between a peer debriefer and the researcher. Study participants describe the counsellor�s self as a multifaceted, positive and integrated entity. The counsellor�s self includes participant�s professional knowledge and skills as well as their beliefs, values, thoughts, feelings, personal style and an unknown aspect of self that some participants referred to as their unconscious. While somewhat influenced by past relationships and the client, the counsellor�s self is primarily autonomous and defined by the individual counsellor. Although the counsellor�s self has the capacity to change over time, in different environments and with different clients, the self also includes notions of stability and consistency. The counsellor�s self is involved in therapy as an inevitable presence, a deliberate tool and a stance. Participants highlighted the importance of self-awareness and various professional and personal constraints on the involvement of self. A central function of the self in therapy is in the therapeutic alliance. The study has implications for the training and supervision of counsellors and future psychotherapeutic research.
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Reupert, Andrea E. "The counsellor's self in therapy /." Access full text, 2004. http://www.lib.latrobe.edu.au/thesis/public/adt-LTU20050404.161132/index.html.

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Thesis (Ph.D.) -- La Trobe University, 2004. Submitted to School of Educational Studies, Faculty of Humanities and Social Sciences, LaTrobe University, Albury-Wodonga Campus.
Includes appendices. Bibliography: p. 189-210.
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Luczaj, Sarah. "Felt senses of self and no-self in therapy." Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/59247/.

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The thesis develops Gendlin's concept of the felt sense in two directions, and introduces parallel concepts of self. It starts by examining western and eastern cultural contexts, neuroscientific conceptualisations and linguistic issues as they relate to self, using the lens of Gendlin's two ways of relating to the world ̶ interpreting according to the unit model and thinking beyond patterns, to point out conceptual confusions. Buddhist philosophy and practice are discussed as methods of undoing such conceptual confusions in order to relieve suffering, with self as an independent, stable, substantial entity being the primary example of such a confusion. Dualism is identified as the basic misconception from which suffering ensues. Non-duality is investigated as a spiritual endstate, an integral part of the goals of humanistic therapies and an intrinsic element in 'carrying forward', then compared with Gendlin's implicit intricacy, Sartre's Being-in-itself and intersubjective theories. A small qualitative study investigates what happens when felt senses of self are intentionally produced or accessed by focusing. A continuum of experiences is described, ranging from self to no-self, with trauma proving a major block to both self and no-self experiencings. The felt sense is re-defined in two ways, as an extending boundary and as a direct referent. A sense of self is also considered both as a boundary drawing exercise, and a direct referent. Self may function in either of these forms on a relative level, constructively or destructively, according to circumstances and conditions, while on an ontological level no such single entity may be proven to exist. The conclusion is drawn that self and no-self form a kind of twisting human thread, which shows, at any one moment, just one side of a duality. These sides are conceptually, rather than actually, distinct.
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Hannen, Elaine. "Narrative therapy with self-cutting adolescents." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506261.

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This qualitative study assesses the use of narrative therapy with self-cutting adolescents. The researcher, formally trained in narrative therapy, delivered a six to eight week narrative intervention separately to two self-cutting adolescent girls referred by their schools to an Educational Psychology Service. The study addressed four research questions. Pre- and post intervention self-report measures and parental reports were used to investigate research question no. 1: 'What effect does narrative therapy have upon the mental health of self-cutting adolescents?' Pre- and post-intervention narrative assessment interviews, and information from the intervention session transcripts, were used to compare the adolescents' pre- and post- intervention 'self-stories' and address research question no. 2: 'How does narrative therapy affect the self-stories of self-cutting adolescents?' The adolescents' views of the helpfulness, or otherwise, of several narrative practices, including outsider witness groups, were elicited using a post-intervention semi-structured interview and questionnaire. Narrative processes were explored and the adolescents' responses mapped using maps of narrative practice (White, 2007) to address research question no. 3: 'What narrative therapy practices do self-cutting adolescents consider to be helpful?' The study also examined how the researcher, working as an EP, used narrative therapy. This information was used to address research question no. 4: 'How might EPs use narrative therapy in their work?' The study findings indicated that narrative therapy may be a promising intervention for improving the mental health and emotional well being of self-cutting adolescents. A model for the use of narrative therapy by EPs is proposed.
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Ahmed, Aya. "Self Limiting Therapy in Deep Dentinal Lesions." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-74946.

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6

Britt, Eileen Frances. "Enhancing Diabetes Self-Management: Motivational Enhancement Therapy." Thesis, University of Canterbury. Psychology, 2008. http://hdl.handle.net/10092/1479.

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The effectiveness of Motivational Enhancement Therapy (MET), a brief four session form of Motivational Interviewing (MI), provided by diabetes health practitioners at a hospital-based clinic, in improving diabetes outcome and self-management of Type 1 and Type 2 diabetes was evaluated using quasi-experimental designs (i.e., non-random control group and multiple baseline designs). Study 1 evaluated if MET provided by Diabetes Nurse Educators (DNEs) was effective in improving diabetes outcome (i.e., blood glucose and lipids) and diabetes self-management, and compared its effectiveness to the current standard treatment which comprised Patient Education (PE). Study 2 evaluated if the results of Study 1 could be generalised to Dietitians providing the intervention. Study 3 evaluated the effects of MI training and post-training supervised practice on practitioner and patient behaviour. Specific hypotheses (Studies 1-2) were that MI would lead to improved diabetes outcome through improved diabetes self-management, and would be more effective than PE. Further, training in MI plus supervised practice was predicted to lead to Nurse Educators behaving in ways consistent with MI and as a result the participants would exhibit less resistance and increased change talk than participants receiving PE (Study 3). The results suggest that MET was well received by the participants, and contributed to improved diabetes outcome (e.g., lowered blood glucose) and diabetes self-management (e.g., self-monitoring of blood glucose and dietary compliance), and may have been more effective than PE, although high variability made conclusions uncertain. Evidence of generalisation across participants, intervention staff, and outcomes is provided. Additionally, evidence is provided that with two days training plus supervised practice the DNE were able to practice MET to at least a beginning level of competency in MI and that as a result the participants behaved in ways consistent with MI theory (i.e., showed less resistance and increased change talk).
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Caldwell, Jennifer E. "Self-assessments skills of occupational therapy students." Thesis, Robert Gordon University, 1997. http://hdl.handle.net/10059/610.

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Increasingly health workers are expected to self-evaluate within the work-place thus raising the question as to how they develop such skills. To date there has been very little research on self-assessment in higher education courses which prepare health professionals for their future careers. The project aimed to investigate occupational therapy students' self-evaluation skills during their professional education and within their first work-place. This practice based investigation was conducted by a member of academic staff in one of the two centres in Scotland offering a BSc in Occupational Therapy course. Data was collected from two different universities offering the course, the study period was the academic years from 1992 to 1996. Four different research tools were used, a content analysis of relevant course documents was carried out; 113 students and 15 academic staff were surveyed using questionnaires, with regard to their understanding and use of self-assessment within the course; self-grading of academic work by three cohorts of students (n=113) was conducted and fifteen graduates and workplace supervisors health care and social work were interviewed through the use of repertory grid interviews. Self-evaluation was emphasised and strongly, linked to professional development, within the course documents of both universities. Students and academic stab identified clinical placements as the area within which, most commonly selfassessment occurred and developed. Students were generally positive with regard to self-assessment being used within the academic components of the course, however, staff were more hesitant. The students consistently under-rated their academic assessments although the majority were within a five-percent range of the experts' marks. One cohort of students did demonstrate an improvement in self-assessment over the three years but similar trends were not detected with the other two cohorts. The repertory grid interviews produced a large number of constructs (507 constructs). It would appear that graduates are able to self-assess accurately within the work place, as there was high agreement between graduates and supervisors regarding the graduates' skills and abilities. In conclusion this investigation indicates that there are discrepancies between course aims and objectives and the reality of self-assessment in the educational context. Although students have the opportunity to practice self-assessment within the academic situation they are limited in their ability to self-assess accurately. They are, however, very confident at self-assessing within the workplace. This confidence may be linked to the fact that as students self-assessments was practised during the clinical component of the course. There is a need for further research with more cohorts being followed throughout the length of their course and also cohorts within other courses.
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Sweetman, Suzanne. "A soul approach to art therapy self-inquiry." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0016/MQ47879.pdf.

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Dil, Jonathan. "Murakami Haruki and the search for self-therapy." Thesis, University of Canterbury. Languages and Cultures, 2008. http://hdl.handle.net/10092/1004.

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This thesis offers a reading of the first eleven novels of popular Japanese novelist Murakami Haruki, as well as a selected number of his short-stories and non-fictional works, as an evolving therapeutic discourse. In short, it is a response to Murakami's own claim to have started writing fiction as a means of self-therapy. Murakami, I will argue, is primarily responding to existential anxieties that have been magnified by conditions of cultural decline in late-capitalist Japan. His resulting therapeutic discourse shares interesting parallels with certain psychoanalytic theories of the twentieth century. Previous psychoanalytic readings of Murakami's work have tended to take either the writings of Carl Jung or Jacques Lacan as their starting point. This thesis will argue, however, that both theoretical frameworks are needed if one is to truly understand where Murakami is coming from. This kind of therapeutic reading might seem to justify those critics who see only the escapist elements in Murakami's fiction and who fault him for failing to engage fully with the important political and social issues of his day. In fact, a therapeutic reading, I will argue, is the best way to see how closely related Murakami's search for self-therapy and his growing search for commitment really are.
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Law, Ian McLaren. "Self research : the intersection of therapy and research." Thesis, Manchester Metropolitan University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443301.

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Bitter, James. "Self-Disclosure and Storytelling in Adlerian Family Therapy." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/6117.

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Chapman, Anne Marie. "Asthma and self-healing, a holistic art therapy approach." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0009/MQ29150.pdf.

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Bitter, James Robert, and Rebekah J. Byrd. "Human Conversations: Self Disclosure & Storytelling in Adlerian Therapy." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/920.

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Starting with Adler’s original work with families in an open forum, there is a long history of both self-disclosure and storytelling in therapeutic practice. This presentation traces that history and identifies the purposes and goals of these interventions in Adlerian therapy. Demonstrations of effective use are provided. Participants will learn the purposes and therapeutic goals for self-disclosure & storytelling in Adlerian counseling & therapy. Participants will learn guidelines for appropriate use of self-disclosure and storytelling in therapy.
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Bitter, James Robert, and Rebekah J. Byrd. "Human Conversations: Self-disclosure & Storytelling in Adlerian Therapy." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/908.

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15

Heath, Amy Elizabeth. "Self-regulated Learning in Doctor of Physical Therapy Students." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216572.

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Educational Psychology
Ph.D.
There is a paucity of adult professional education literature, yet there are multiple theories and models from which to extrapolate information regarding learning in this population, including self-regulated learning theory and adult learning models. The first aim of this study was to explore these bodies of literature and provide a compelling argument for how these theories and models may be considered relative to each other. The second aim of this study was to provide empirical support for the theoretical framework within the professional education population, specifically for Doctor of Physical Therapy (DPT) students. Participants included 232 DPT students from a large, research-intensive university in the mid-Atlantic region. The Self-directed Learning Readiness Survey for Nursing Education (SDLRSNE) (Fisher, King, & Tague, 2001) was administered to five cohorts of students seven times throughout the duration of the DPT program. T-tests and ANOVAs were conducted to determine cohort differences. The data were collapsed across time in order to generate longitudinal growth curve models. Results revealed that the SDLRSNE is an internally consistent tool to utilize with DPT students and that the majority of DPT students were self-regulated learners. Results from the growth curve models indicated that self-regulated learning increased across time, was discontinuous within the DPT program, and that participation in clinical education experiences coincided with the change in slope of the model that best fit the data. Additionally, results indicated that the age of a student (traditional: age 19-24 versus nontraditional: age 25+) significantly predicted Desire For Learning subscale scores.
Temple University--Theses
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Rose, Grace (Grace Elizabeth). "History of Self-Disclosure and Premature Termination from Therapy." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc504574/.

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The present study was designed to investigate the hypothesis that female clients who tend to terminate therapy prematurely will have been assigned to a male therapist. The study also tested the hypothesis that female clients who defect from therapy will have reported a history of low self-disclosure to individuals of the same sex as their therapist. Neither hypothesis was supported by the results of this study, but findings suggest a possible bias in the manner by which male and female therapists select their clients for therapy. It also appears that female defectors may be over-identifying with their family of origin or that they may be overly dependent on it as a resource system. This may be the reason for their apparent difficulty in developing a prototype that will accommodate their therapist.
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Rowe, Jacob. "Self-directed tablet-based naming therapy in chronic aphasia." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58353.

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Background: The recent interest in the use of mobile devices (like iPads and their application programs; apps) in aphasia therapy has been motivated in part by a belief that they could facilitate self-directed home practice with minimal therapist supervision. Such practice in turn could allow people with aphasia to receive more therapy, without taxing current clinical resources even further. However, it is unknown whether mobile technology can feasibly facilitate self-directed practice. Furthermore, it is unclear whether this kind of therapy can improve outcomes, and there are doubts about the quality of the therapy process when therapy is provided without the expertise of a therapist. Aims: This study aimed to explore the feasibility, therapeutic effect, and therapy process of a naming therapy using an iPad-based therapy app for minimally-supervised self-directed home practice in chronic post-stroke aphasia. Method: A single-subject experiment using a multiple baseline design was replicated across three participants with chronic aphasia, who independently used an iPad-based therapy app to practice naming pictures with the support of cues. Outcome measures included extensive usage and accuracy data unobtrusively collected using the app’s internal logging system, pre- and post-therapy language measures, and qualitative semi-structured interviews to explore participants’ experiences of therapy and perceptions of therapy effects. Results: Therapy was found to be accessible and acceptable for participants with aphasia; however, problems were identified with the therapist’s administrative role in developing and managing word sets, and monitoring therapy progress. Participants demonstrated medium to large naming accuracy gains for practiced words, but minimal gains for unpracticed words. Enabling participants to direct their own therapy process led them to spontaneously enact therapy in ways generally similar to how a therapist might. Conclusion: Despite limitations, self-directed practice using mobile technology may have the potential to improve outcomes by making ongoing long-term gains feasible, and to foster greater collaboration and shared expertise between therapists and people with aphasia. Findings were discussed in terms of suggestions for future research and therapy app development that could allow mobile technology to deliver on this potential.
Medicine, Faculty of
Audiology and Speech Sciences, School of
Graduate
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Birch, Maxine. "The quest for self-discovery : the reconstruction of self identity stories in alternative therapy groups." Thesis, Oxford Brookes University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363640.

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19

Dale, Lucinda M. "The development of self-awareness in graduate occupational therapy students." Virtual Press, 2001. http://liblink.bsu.edu/uhtbin/catkey/1203648.

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The purpose of this qualitative study was to describe accurately the methods used by occupational therapy graduate students to develop self-awareness, a necessary foundation for the development of professional behaviors. Self-awareness, defined as a deep understanding of one's emotions, strengths, weaknesses, needs, and drives (Goleman, 1995), was identified in the literature as a component of or a prerequisite for the development of skills in leadership, multicultural competency, clinical reasoning, and continuing competence.Purposive sampling was used to identify student participants from a private university in the mid-west. Eleven participants completed the study. Evidence was gathered through semi-structured interviews; observations of classroom activities, professional meetings, and clinical settings; and examination of documents which included journal entries, class assignments, and professional development plans.Findings suggest that students' development of self-awareness is facilitated by a hierarchical sequence of activities which provide them with opportunities to describe features of their contexts, to recognize and define personal values and beliefs and those values and beliefs of others, and to define relationships. Reflection stimulated consideration of students' reactions in particular contexts and development of a new perspective. Students who appraised themselves realistically anticipated their responses in future events and made plans to alter undesired behaviors. Although the literature supported feedback as one way in which to facilitate self-awareness, students were reluctant to give candid feedback to peers and rarely sought feedback, unless required, for their own performance. Evaluations of behaviors, relationships, and belief systems were activities located at higher levels in the hierarchy requiring students to gain skills in recognition and description first in order to proceed to these levels.The findings point to the importance of self-awareness for personal and professional growth, and the need for educators to utilize a variety of strategies by which to facilitate self-awareness development. A revision of Fidler's checklist may provide a foundation for the development of a tool which could be a useful way in which to target behaviors necessary for development of self-awareness.
Department of Educational Leadership
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20

Bitter, James Robert, and Rebekah J. Byrd. "Human Conversations: Self-Disclosure and Storytelling in Adlerian Family Therapy." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/872.

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Bitter, James Robert, and Rebekah Byrd. "Human Conversations: Self-Disclosure and Storytelling in Adlerian Family Therapy." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/5209.

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Self-disclosure and storytelling have been part of Adlerian family therapy and counseling since Adler's public work with families and educators in Austria. The benefits of both—as well as the cautions for use—have been well documented in the literature. Still, those who are recently trained and/or new to the profession often seem reluctant to engage clients in the kind of human, person-to-person (and person-revealing) conversations that let clients know they are not alone in the world and that encourage them to be imperfectly human. The use of self-disclosure and storytelling occurs less in training programs that put a premium on "taking a professional stance" and with practicum/internship students who are still unsure of how to use themselves in the therapeutic process. The authors describe the purposes and constructions of effective self-disclosure and storytelling in Adlerian family therapy and suggest guidelines for therapeutic decision-making and use.
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McKinnon, Danielle. "Exploring self-compassion : group music therapy with sexual assault survivors." Diss., University of Pretoria, 2018. http://hdl.handle.net/2263/65532.

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Sexual abuse is a traumatic event, which leaves survivors with mental, physical and emotional needs. The aim of this qualitative study was to explore whether closed group music therapy sessions could enhance self-compassion, as reported and expressed by sexual abuse survivors. The music therapy process that was conducted was designed to facilitate the three core constructs of self-compassion as researched by Kirsten Neff (2003a), namely self-kindness, common humanity and mindfulness. The study explored the experiences of six sexual abuse survivors residing at a community centre in Lavender Hill, Cape Town, South Africa. Music therapy sessions took place once a week for a period of six weeks and the main musical components of the sessions included song-writing, group singing, drumming, vocal and instrumental improvisations and relaxation. The findings emerged from the interpretive phenomenological analysis of the individual semi-structured interview transcripts and thick descriptions of excerpts of the audio recordings. From the findings of this study it was concluded that the group music therapy sessions offered sexual abuse survivors opportunities for: self-exploration, self-confidence, interpersonal connections, the experience of being supported, encouragement, enjoyment and vitality, stress relief, emotional exploration and expression, and transformation of perspectives. These findings were represented by the following three main themes; characteristics of their lifeworlds, the affordances of music therapy for the group, and the group’s experience of transformation, which are then discussed in relation to self-compassion.
Dissertation (MMus)--University of Pretoria, 2018.
Music
MMus
Unrestricted
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Rushing, Jamie E. "Music Therapists’ Self-Compassion, Compassion for Others, and Professional Quality of Life." UKnowledge, 2017. http://uknowledge.uky.edu/music_etds/90.

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As helping professionals, music therapists show compassion to their clients but may lack necessary self-care skills to prevent burnout and promote well-being. Due to a lack of research in this area, this study investigated reported levels of compassion for others, self-compassion, burnout, secondary traumatic stress, and compassion satisfaction among music therapists in relation to age, gender, and years of professional experience. A survey of 575 board certified music therapists in the USA revealed higher levels of compassion for others than self-compassion, low levels of burnout and secondary traumatic stress, and high levels of compassion satisfaction. Burnout strongly negatively correlated with both self-compassion and compassion satisfaction and strongly positively correlated with secondary traumatic stress. A MANCOVA revealed significant differences in compassion for others and compassion satisfaction based on gender, with female participants reporting significantly higher scores for both constructs. Additionally, there was a trend related to self-compassion and compassion levels increasing over time. There were strong associations between compassion and self-compassion with burnout and secondary traumatic stress; therefore, it would benefit music therapists to cultivate compassion practices to lower burnout risk.
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Potts, Sarah A. "Putting Weight in Context: Acceptance and Commitment Therapy (ACT) Guided Self-Help for Weight Self-Stigma." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7227.

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Obesity is a serious public health issue within the U.S. and minimal long-term success is found with standard behavioral weight-loss treatments. Typical weight-loss interventions do not acknowledge psychological factors, such as weight-related stigma, which may play a role in the development and maintenance of poor coping behaviors, such as unhealthy eating patterns. Individuals who are obese may often experience weight-related stigma present in society and are ultimately at risk for weight self-stigma, which is related to poor health behaviors and increased psychological distress. Acceptance and commitment therapy (ACT), can be effective for treating numerous mental health presentations, might also be effective in decreasing weight self-stigma and improving health behaviors. Guided self-help may be particularly attractive to individuals struggling with weight self-stigma because it allows for greater flexibility and personal choice. There have been no previous randomized controlled trials evaluating guided self-help for weight self-stigma and health behavior change in obese populations. This study reports the results of a randomized controlled trial of ACT guided self-help for weight self-stigma comparing two versions of guided self-help with varying levels of support versus waitlist control. Each active condition provided unique levels of guided self-help to evaluate whether phone coaching enhanced the program. Results showed both active conditions were highly acceptable, although greater satisfaction with support and greater follow-through with book reading was found for those who received phone coaching. There were significant improvements at post in binge eating, physical activity, psychological distress, weight self-stigma, and weight-related psychological flexibility for both active conditions versus waitlist. Mediational analyses showed significant treatment effects, such that weight self-stigma and weight-related psychological flexibility fully and separately accounted for the relation between ACT guided self-help and binge eating behavior. The findings from this study provide the first randomized controlled trial data of an effective intervention for weight self-stigma. Clinical implications, limitations, and future directions are discussed.
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Cavasinni, Christine. "A Study of Art Therapy in Identity Exploration and Self-Efficacy." Thesis, Notre Dame de Namur University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10689764.

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This paper illustrates the impact of an 8-week art therapy regimen on the perceived self-efficacy of participants seeking dual diagnosis treatment for the Substance Use Disorders (SUDs). It was hypothesized that pre- and post-test results of the General Self-Efficacy Scale (GSE), the State-Trait Anxiety Inventory for Adults (STAIAD), and the Quick Inventory of Depressive Symptomology Self-Report (QIDS-SR) would reflect an increase in perceived self efficacy, and decreases in anxiety and depressive symptoms. The STAIAD and QIDS-SR were included in the study as indicators of well-being. The regimen was designed by the student researcher and focused on identity exploration through the lens of Humanistic theory. The regimen is outlined week-by-week, illustrative case studies and group responses are described, and empirical assessment of the regimen?s efficacy is provided. Discussion focuses on the significance of results obtained and the need for further research. Paired samples testing showed an increase in perceived self-efficacy and decreases in anxious and depressed symptoms, as predicted. Small population size meant that these results were not statistically significant. However, qualitative results indicate that participants found the 8-week regimen helpful. Participants vocalized a belief that art-making provided emotional release through externalization, a tool for self-expression, and a source of pride in Self. Jungian concepts presented also resonated with participants, with some sharing with the group regarding ways in which these concepts related to themselves and provided groundwork and structure for understanding the Self.

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Kaldo, Viktor. "Cognitive Behavioural Therapy as Guided Self-help to Reduce Tinnitus Distress." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8927.

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Eberl, Carolin, Isabell Winkler, Steffen Pawelczack, Eva Tröbitz, Mike Rinck, Eni S. Becker, and Johannes Lindenmeyer. "Self-esteem consistency predicts the course of therapy in depressed patients." Public Library of Science, 2018. https://monarch.qucosa.de/id/qucosa%3A31242.

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Previous studies on self-esteem and depression demonstrated the usefulness of both implicit and explicit self-esteem as well as their congruence (also known as self-esteem consistency) to predict future depressive symptoms. High self-esteem consistency describes when implicit and explicit self-esteem match (e.g., both high or both low). In the current study, we investigated if implicit and explicit self-esteem and self-esteem consistency predict the course of treatment efficacy of a cognitive behavioral depression therapy. Explicit self-esteem was assessed by the Rosenberg Self-Esteem Scale, implicit self-esteem by a priming task. Participants were 31 patients with a major depressive or recurrent depressive disorder receiving cognitive behavioral therapy treatment in an inpatient setting. Self-esteem measures were administered before treatment. The development of depression symptoms during treatment and at the 4-month follow-up was measured on the Beck Depression Inventory. Implicit and explicit self-esteem did not predict the course of the therapy. Patients with congruent self-esteem, however, improved faster and showed lower severity of symptoms throughout treatment. In contrast, neither explicit nor implicit self-esteem nor self-esteem consistency predicted the stability of effects after treatment. Practical implications such as targeting discrepancies in self-esteem during treatment are discussed.
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Peebles, Larry Mason. "Improving self-efficacy in college students: A modified adventure therapy program." Thesis, University of North Texas, 2006. https://digital.library.unt.edu/ark:/67531/metadc5443/.

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Adventure therapy employs a technique in which therapists use controlled amounts of stress to bring about change in the behavior of clients. One of the domains in which adventure therapy reports improvement is that of self-efficacy. Perceived self-efficacy is the belief that individuals have in their ability to overcome and change their situation in life. This study examines the effect of a modified adventure therapy program on the perceived self-efficacy of college students who were enrolled in an Outdoor Pursuits course at a major metropolitan university. Students received 16 weeks of outdoor adventure therapy programming that culminated in a voluntary weekend camping trip. The students were administered the General Self-Efficacy (GSE) scale on the second day of class to determine a baseline level of self-efficacy to be compared to the posttest completed on the last day of class. The study examined 3 consecutive semesters of archival data collected by the researcher while instructing the course. Fifty-six participants across the 3 semesters were usable for data analysis. The results show there is a significant difference between students' level of perceived self-efficacy from pre- to posttest, and no difference in the effect on gender, classification of students, or the participation of the student in the weekend campout. Therefore, the 16 week program improved students' perceived self-efficacy regardless of whether or not they participated in the weekend campout.
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Giordano, Maria A. "Effectiveness of a Child-Centered Self-Reflective Play Therapy Supervision Model." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2531/.

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This study investigated the effectiveness of a child-centered self-reflective play therapy supervision model with master's level counselor education graduate students. Specifically, this research determined if the self-reflective play therapy supervision model facilitated significant change in the master's level play therapists': (a) child-centered attitude; (b) knowledge of child-centered play therapy; and (c) confidence in applying play therapy skills. This study also measured change in the skills of: (d) tracking behavior, (e) reflecting content, (f) reflecting feelings, (g) facilitating decision-making and self-responsibility, (h) facilitating esteem-building and encouragement, (i) encouraging the child to lead, (j) setting limits, (k) ability to be congruent, (l) quality of non-verbal responses and (m) quality of verbal responses. The experimental group students (N=15) utilized a 15 week self-reflective play therapy supervision model. This model consisted of a manual that reviewed the rationale and utilization of six therapeutic responses of child-centered play therapy, self-assessment forms that were completed after reviewing weekly play therapy session videos and weekly group supervision. The control group (N=15) received supervision during the 15 weeks but did not use the manual or the self-assessment forms. Prior to working with their first client and again at the end of the semester practicum, the play therapy supervisees completed the Play Therapy Attitude-Knowledge-Skills Survey. Each supervisee submitted a pre-tape and a post-tape of a play therapy session during their semester practicum. Four doctoral students rated play therapy session video tapes using the Play Therapy Skills Assessment form. The play therapy session video tapes were assessed by objective raters. An independent t-test utilizing the gain score as the dependent variable revealed that play therapy supervisees in the experimental group showed a statistically significant increase in their ability to implement the skill of tracking behavior, facilitating decision-making and self-responsibility and facilitating esteem-building and encouragement. In addition, the experimental group supervisees showed a significant increase in the quality of their verbal responses and a marginally significant increase in their ability to reflect content and reflect feelings. Limited statistical significance in the play therapy supervisee's improvement of skills possibly could be attributed to the small sample size and lack of random assignment of participants to the experimental and control group. The positive trends in the play therapy supervisees increased ability to implement play therapy skills warrants additional research of the self-reflective supervision model.
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Yousef, Dina K. "Group Activity Play Therapy for Preadolescents: Effects on Low Self-Esteem." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc862864/.

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Research shows that preadolescent females are more prone to negative self-perceptions than their male counterparts which places them at greater risk of developing mental health problems stemming from low self-image. The purpose of this randomized, controlled outcome study was to examine the effectiveness of group activity play therapy (GAPT) compared to an evidenced based social skills/self-esteem group. Participants were 29 fourth and fifth grade girls in two Title I schools in the southwest U.S. referred by teachers and school counselors as presenting with low self-esteem. Participants identified as 45% Latina, 38% Caucasian, 14% African American, and 3% Asian. Children were randomly assigned to either 16 sessions of GAPT (experimental group; n = 15) or 13 sessions of an evidenced based social skills/self-esteem group intervention (control group; n = 14). Results from a 2 (Group) by 3 (Times) repeated measures ANOVA indicated that, compared to the control group over time, the GAPT group reported statistically significant improvement in self-esteem with a moderate to large treatment effect. Teachers did not report a statistically significant difference between the two groups over time. However, teachers reported noteworthy improvement for children in both treatment groups, with generally stronger improvement for the GAPT group. Overall, results indicate that GAPT may be a promising school-based intervention for preadolescent females suffering with low self-esteem.
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31

Best, Helene. "Group music therapy utilising marimba playing for children with low self-esteem." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/43760.

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Qualitative research was conducted to explore if, and how, music therapy utilising group marimba playing can facilitate increased self-esteem for children in a small independent school in the Western Cape. The case study involved ten weekly group music therapy sessions as well as a performance session. African marimbas were used in conjunction with other methods of active music making in the group sessions. Excerpts of video recordings were analysed and the Behavioural Indicators of Self-esteem (BIOS) rating scale was completed for each child pre- and post-intervention in order to examine whether music therapy sessions facilitated changes in children’s self-esteem that transferred to the classroom situation. The findings from the qualitative analysis of video excerpts indicate that group music therapy intervention utilising marimba playing appeared to facilitate the development of self-esteem. Experiences were provided to increase the participants’ sense of worthiness and competence. Results of the BIOS scale could not be statistically analysed due to the small sample size, but the data suggests that the music therapy intervention had an impact that carried over to the classroom situation on participants who were assessed to have lower self-esteem before the intervention (compared to others in the sample) as observed in their classroom behaviour.
Dissertation (MMus)--University of Pretoria, 2015.
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Mayorga, Carla Cecilia. "Self-Reported and Observed Cultural Competence and Therapeutic Alliance in Family Therapy." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/163.

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Because of its political and philosophical launching ground (Arredondo & Perez, 2006), cultural competence did not begin as an empirical research program, and as a result, there remains disagreement about how to define and measure cultural competence. Although the application of cultural competence remains unclear to some psychologists (Fuertes et al., 2006), it is now common knowledge that the therapeutic alliance is a statistically and clinically significant contributor to effective therapy. This pilot study merges two prominent bodies of literature, cultural competence and therapeutic alliance, with the underlying assumption that a culturally competent counselor will be able to provide effective service through the therapeutic relationship (Pope-Davis et al., 2002). This pilot study was designed to provide information about the relationship between therapists' self-reports and their observed behaviors regarding cultural competence (CC), examine how therapists' CC facilitates the formation of working alliances, and examine the role of CC in predicting parent-child discrepancy in alliance. Participants were family therapists and family members involved in a multi-site clinical trial study (Parent Study) evaluating Brief Strategic Family Therapy (BSFT™; Szapocznik, Hervis, & Schwartz, 2003). A total of 14 therapists from 8 community treatment programs from across the country were included in the rating portion of the study. The Parent Study included African American and Hispanic families with adolescents ages 12-17, mostly referred from the juvenile justice system. Scores from Roysircar's Multicultural Counseling Inventory (MCI; 1994) and Cultural Diversity Observer Rating Scale (CDORS; 2005) were compared. Observed therapeutic alliance was evaluated using the Vanderbilt Therapeutic Alliance Scale-Revised. The associations were evaluated with 3 multilevel univariate linear models using HLM software. Since 6 of 14 therapists (43%) completed the MCI, the pilot study was completed without self-reported competence as a predictor of therapeutic alliance (only CDORS was used). The results of this study failed to provide support for the hypothesized relationships between cultural competence and therapeutic alliance. These results are discussed in light of the methodological limitations of this study and suggestions are made to improve future investigations in this area.
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Campbell, Patricia A. "Therapeutic self-care demands perceived by out-patients receiving external radiation therapy." Virtual Press, 1990. http://liblink.bsu.edu/uhtbin/catkey/722453.

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34

Beharry, Prya. "Acceptance and commitment therapy for public speaking anxiety: A self-help format." The University of Waikato, 2008. http://hdl.handle.net/10289/2442.

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A non-concurrent multiple baseline design across eight participants was used to determine whether working through Hayes and Smith's (2005) book would help those with public speaking anxiety. Hayes and Smith (2005) is based on Acceptance and Commitment Therapy. It encourages people to accept internal experiences as opposed to avoiding and struggling with them. For the purposes of this study, the book was divided into nine components, which participants discussed with the researcher. They also completed measures daily, during baseline and over the intervention period, as well as a battery of tests pre-baseline, mid and post intervention. The multiple baseline data showed that self-reported willingness to approach public speaking situations increased while self-reported avoidance decreased over the intervention. The pre and post measures also showed avoidance of internal experiences decreased significantly after the intervention. These outcomes are in line with changes suggested to result from engaging in such a therapy. The pre and post results also showed that quality of life increased significantly from mid to post-intervention. However, engagement with values did not change. While this measure is expected to change after such an intervention, this result may have occurred because the ideas about values were introduced last in the book. The intervention also led to significant decreases in anxiety, significant changes in thoughts about public speaking and significant increases in anxiety control as shown by the test battery. These findings are positive but are not predicted by processes posited for this therapy. However, there was no control group so these pre vs post comparisons must be interpreted with caution. Despite this limitation, the results suggest that the book, together with therapist contact, can help those with public speaking anxiety.
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Parker, Phyllis R. "Alcoholism, group therapy and self-esteem, residential group treatment in the North." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0034/MQ62489.pdf.

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36

Barrett-Naylor, Ruth. "Acceptance and commitment therapy guided self-help for psychogenic non-epileptic seizures." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/44238/.

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Psychogenic non-epileptic seizures (PNES) are a relatively common condition, however, seizures can be debilitating for patients and are associated with high levels of psychological distress, reduced quality of life and reduced functionality. Despite the debilitating effects of the condition, there is thus far no recommended treatment. Although psychological therapy is often sought following the diagnosis of PNES, there remains relatively little research in the area comparing treatment efficacy. Nevertheless, many treatment efficacy studies focus on the application of cognitive behavioural therapy to PNES and the results produced so far appear promising, however, the psychotherapeutic mechanisms of change for such therapies are less clear. Acceptance and Commitment Therapy (ACT) is a third-wave behavioural approach based on theoretical mechanisms of change. ACT may have benefits over other traditional therapies, as its contextual approach may be more acceptable to individuals with PNES, especially if they have had difficulty in adjusting to the concept that their seizures are caused by psychological, rather than physical processes. A single case experimental design was carried out to assess the efficacy of an ACT guided self-help intervention on psychological flexibility, psychological distress, quality of life and seizure frequency. Participants also completed a qualitative change interview at one-month follow up. The intervention was replicated six times. All participants demonstrated an increase in psychological flexibility following the ACT self-help intervention. Four of the six participants demonstrated reliable improvements in quality of life and psychological distress. The same four participants also reported a significant decrease in seizure frequency following the intervention, with three participants reporting that they were seizure free at one-month follow-up. Triangulation of the quantitative time-series data and qualitative change interviews indicated that openness to awareness processes (acceptance and cognitive defusion) were key mechanisms of change for individuals with PNES. The study demonstrated the utility of an ACT treatment approach delivered in a self-help format for individuals with PNES. The implications of the study findings for future research and clinical practice are discussed.
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Ross, Helen. "Dialectical behaviour therapy for adolescents who repeatedly self-harm : a qualitative study." Thesis, Bangor University, 2002. https://research.bangor.ac.uk/portal/en/theses/dialectical-behaviour-therapy-for-adolescents-who-repeatedly-selfharm--a-qualitative-study(d0104182-26e3-46df-9f7b-bce986401002).html.

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Despite the level of concern generated by adolescents who repeatedly self-harm, there is a dearth of empirically validated interventions for this client group. In the adult domain, dialectical behaviour therapy (DBT; Linehan, 1993) is the only evidence-based intervention for individuals at high risk of repetition, and preliminary research has suggested its utility with adolescents. This study employed a qualitative methodology to evaluate an existing inpatient DBT programme for adolescents with multiple presenting problems including deliberate self-harm. Four female adolescents were interviewed in depth about their experiences and the perceived impact of receiving DBT. Transcripts were analysed for significant and recurrent themes using interpretative phenomenological analysis. Overall, the results supported existing quantitative data indicating that this client group can benefit from DBT. Participants emphasised the role of applying DBT skills in gaining a sense of control over internal experiences and overt behaviours (including self-harm). However, there were marked individual differences in the degree to which such control was attained. Furthermore, for most participants, the effective use of DBT skills was at least partially dependent upon the continued receipt of therapy. Motivation to engage in and comply with therapy appeared to be significantly influenced by participants' perceptions of staff and peers within the inpatient unit. A sense of connection or identification with others emerged as an important source of learning and inspiration, as well as serving to normalise participants' difficulties. The role of social comparison was particularly salient in participants' attempts to make sense of the changes in self since entering DBT. The findings are discussed in relation to the existing literature, with particular emphasis on the extent to which therapeutic processes deemed important by DBT theory were concordant with participants' experiences. Implications for clinical practice are highlighted and directions for future research suggested.
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Lotter, Sané. "The affordances of narrative group music therapy with adolescents who self harm." Diss., University of Pretoria, 2018. http://hdl.handle.net/2263/64975.

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This qualitative study examined how adolescent participants who self-harm narrate motivations for and experiences of self-harm and what a narrative group music therapy process could afford them. Seven participants from a high school in South Africa who engage in self-harm attended narrative group music therapy sessions for six weeks. Multiple interventions were used to create opportunities for self-expression within sessions. Narratives that emerged during this therapeutic process were analysed. Five main narratives were identified: “who I am, becoming and strive to be,” “relationships,” “worldview,” “self-harm,” “music therapy.”
Mini Dissertation (MMus)--University of Pretoria, 2018.
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39

Lee, Ji Hyun. "Group Art Therapy and Self-Care for Mothers of Children with Disabilities." Thesis, Lesley University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10641805.

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The purpose of this study was to examine the effectiveness of a group art therapy intervention on psychological well-being of Korean mothers of children with disabilities. This study employed a quasi-experimental pre- and post-test research design with non-random assignment of participants to either the art therapy intervention group (AG) or the control group (CG). The present study quantitatively examined the effectiveness of the group art therapy intervention using four standardized measurements (Parental Distress sub-scale from Parenting Stress Index-Short Form, Perceived Stress Scale, Beck Depression Inventory-II, & The Multidimensional Scale for Social Support) assessing parenting stress, perceived stress, depression, and perceived social support. In addition, the Draw-a-Person-in-the-Rain (the DAPR) assessment with numerical scoring system was used to assess the mothers’ stress.

A total of 44 participants from multiple regions across Korea were included, and mothers in AG (n = 22) participated in 6 sessions of 100 minutes in length. The results of the statistical analysis showed significant differences between the two groups in parenting stress, perceived stress, and depression with those in the AG reporting a greater decrease in parenting stress, perceived stress, and depression than those in the CG. In terms of perceived social support, no significant difference was found between the AG and the CG. The results of the DAPR-Stress scale showed that stress indicators on the post-drawing assessment decreased significantly compared to the pre-drawing assessment after participating in the art therapy intervention. Thus, the art-based projective drawing assessment (the DAPR) supported the quantitative results of the art therapy intervention on decreasing stress. Overall findings support the effectiveness of the group art therapy intervention in enhancing psychological well-being of Korean mothers of children with disabilities.

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Kinsella, Amanda Jane. "Mindfulness-based cognitive therapy for alcohol dependency and dysregulated mood : investigating self-efficacy and the role of self-compassion." Thesis, University of the West of England, Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570709.

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41

Doremus, Barbara Ann. "PSYCHOLOGIST SELF-DISCLOSURE WITH COURT-MANDATED AND SELF-REFERRED CLIENTS." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1344440734.

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42

Svanberg, Cohen LIna, and Jonathan Cohen. "Compassion Focused Therapy vid ätstörningar- en pilotstudie." Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-33123.

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Compassion Focused Therapy är en integrativ transdiagnostisk behandlingsform som syftar till att öka self-compassion och minska skam och självkritik hos individer med psykisk ohälsa. Skam och självkritik har i hög grad identifierats hos personer med ätstörningar, som också ofta anses svårbehandlade. Denna studie syftade till att undersöka huruvida CFT kan vara ett behandlingsalternativ vid ätstörningar. En single-subject design med upprepade mätningar användes (n=5). Studien visade på tvetydiga resultat men indikerar att en del individer kan vara hjälpta av denna behandling. Fortsatt forskning är således motiverad
Compassion Focused Therapy (CFT) is an integrative transdiagnostic treatment aiming at increasing self-compassion, and reducing levels of shame and self-criticism in individuals with psychiatric illness. High levels of shame and self-criticism have been identified in people suffering from eating disorders, disorders who are usually considered difficult to treat. The aim of the present study was to investigate if CFT could be considered a treatment option for eating disorders. A single-subject design with repeated measures was used (n=5). The results were ambiguous, though indicating that CFT could be helpful for some individuals with eating disorders. Further research is warranted.
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Díaz, Ocaña Raquel. "Recombinant self-assembling nanoparticles for cancer therapy based on toxin and venom compounds." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670483.

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La plataforma desenvolupada d’enginyeria de proteïnes auto-acoblables permet dissenyar nanopartícules únicament proteiques (NPs) capaces d’atacar i actuar selectivament sobre les cèl.lules canceroses mitjançant la interacció amb receptors que es sobreexpressen. Les estructures esfèriques estables de les NPs desenvolupades i la seva mida adequada, en combinació amb els pèptids d’orientació , milloren la seva especificitat. A més, la incorporació de segments de toxina i verí ha millorat els efectes terapèutics d’aquestes estructures que són totalment biocompatibles i que no tenen cap portador extern o material agregat, complint d’aquesta manera amb el nou concepte per a medicaments de precisió, que involucra un fàrmac recombinant lliure de vehicle, auto-acoblat, auto-dirigit i eficient. Una versió modificada de la cadena catalítica ricina A, amb la capacitat de disminuir els efectes secundaris no desitjats de la síndrome de vessament vascular però conservant la seva citotoxicitat natural, es va adaptar a la plataforma de proteïnes. El disseny es va desenvolupar amb el pèptid T22, que s’uneix a CXCR4, en l’extrem N-terminal, i una cua d’histidines a la terminal-C, en combinació amb un fragment del lloc escindible de furina per alliberar la proteïna intracel.lularment, i una seqüència KDEL per evitar la secreció del reticle endoplàsmic. Les NPs de cadena de ricina A solubles purificades dirigides a CXCR4 amb un diàmetre mitjà de 11 nm, van assolir un increment de 100 vegades en la seva citotoxicitat amb un IC50 de 13 ± 0,5 x 10 -9 M en cèl.lules HeLa. També es van produir per mètodes recombinants i es van purificar cossos d’inclusió insolubles de 400-600 nm, amb resultats citotòxics parcials. El mecanisme d’entrada dependent del receptor d’T22-MRTA-H6 es va verificar i avaluar en un model de ratolí amb leucèmia mieloide aguda (AML) mitjançant la injecció sistèmica a la vena de la cua on es va verificar un bloqueig important de les cèl.lules leucèmiques sense toxicitat sistèmica o histològica lateral en els òrgans sans. De manera similar, la clorotoxina (CTX) també es va incorporar a la plataforma de proteïnes per tal d’aprofitar la seva d’orientació i efecte terapèutic en glioblastoma (GBM), ambdues funcions en un sol pèptid. Es van dissenyar dues versions que s’uneixen a la proteïna anexina-2 i la metaloproteinasa de matriu MMP-2; CTX-GFP-H6 i CTX-KRKRK-GFP-H6. Les NPs solubles d’un diàmetre mitjà de 12 nm es van incubar en cèl·lules HeLa, sobreexpressant annexina-2, i en cèl.lules U87MG, sobreexpressant MMP2. Les dues versions eren completament fluorescents, però CTX-GFP-H6 va presentar efectes citotòxics lleus, mentre que CTX-KRKRK-GFP-H6 va mostrar ser més citotòxic en les cèl.lules U87MG que en les cèl.lules HeLa. L’afinitat selectiva de CTX es va confirmar mitjançant l’avaluació de la seva selectivitat utilitzant anticossos monoclonals i un sèrum policlonal contra la proteïna de la superfície cel.lular, actuant com un receptor de la CTX.
La plataforma desarrollada de ingeniería de proteínas autoensamblables permite diseñar nanopartículas únicamente proteicas (NPs) capaces de atacar y actuar selectivamente sobre las células cancerosas mediante la interacción con receptores que se sobreexpresan. Las estructuras esféricas estables de las NPs desarrolladas y su tamaño adecuado, en combinación con los péptidos de direccionamiento involucrados, mejoran su especificidad. Además, la novedosa incorporación de segmentos de toxina y veneno ha mejorado los efectos terapéuticos de estas estructuras que son totalmente biocompatibles y que no tienen ningún portador externo o material agregado, cumpliendo de esta manera con el concepto emergente para medicamentos de precisión que involucra un fármaco recombinante libre de vehículo, autoensamblado, auto-dirigido y eficiente. Una versión modificada de la cadena catalítica de ricina A, con la capacidad de disminuir los efectos secundarios no deseados del síndrome de derrame vascular, pero conservando su citotoxicidad natural, se adaptó a la plataforma de proteínas. El diseño se desarrolló con el péptido T22, que se une a CXCR4, en el extremo N-terminal, y una cola de histidinas en el extremo C-terminal, en combinación con un fragmento del sitio escindible de furina para liberar la proteína intracelularmente, y una secuencia KDEL para evitar secreción del retículo endoplásmico. Las NPs de cadena de ricina A solubles purificadas dirigidas a CXCR4, con un diámetro promedio de 11 nm, alcanzaron un incremento de 100 veces en su citotoxicidad con un IC50 de 13 ± 0,5 x 10 -9 M en células HeLa. Pero también se produjeron por métodos recombinantes y se purificaron cuerpos de inclusión insolubles de 400-600 nm, con resultados citotóxicos parciales. El mecanismo de entrada dependiente del receptor de T22-mRTA-H6 se verificó y evaluó en un modelo de ratón con leucemia mieloide aguda (AML) mediante la inyección sistémica en la vena de la cola, donde se verificó un bloqueo importante de las células leucémicas sin toxicidad sistémica o histológica lateral en los órganos sanos. De manera similar, la clorotoxina (CTX) también se incorporó a la plataforma de proteínas con el fin de aprovechar su direccionamiento y efecto terapéutico en glioblastoma (GBM), ambas funciones en un solo péptido. Se diseñaron dos versiones que se unen a la proteína anexina-2 y la metaloproteinasa de matriz MMP-2; CTX-GFP-H6 y CTX-KRKRK-GFP-H6. Lss NPs solubles, de un diámetro promedio de 12 nm, se incubaron en células HeLa sobreexpresando anexina-2, y en células U87MG, sobreexpresando MMP2. Ambas versiones eran completamente fluorescentes, pero CTX-GFP-H6 presentó efectos citotóxicos leves, mientras que CTX-KRKRK-GFP-H6 mostró ser más citotóxico en las células U87MG que en las células HeLa. La afinidad selectiva de CTX se confirmó mediante la evaluación de su direccionamiento utilizando anticuerpos monoclonales y un suero policlonal contra la proteína de la superficie celular, actuando como un receptor de la CTX.
The developed self-assembling platform allows the engineering of protein-only nanoparticles (NPs) capable to target and act selectively over cancer cells by means of the interaction with overexpressed receptors. The stability of the spherical NP structures and their adequate size, in combination with the involved targeting peptides, enhance their specificity. Also, the novel incorporation of toxin and venom segments have improved the therapeutic effects of these fully biocompatible materials, without the need of any external carrier or added material, thus fulfilling the newfangled concept for precision medicines that involve self-assembled, self-targeted and efficient vehicle-free recombinant drugs. A modified version of the catalytic ricin A chain, with the ability to diminish the undesired vascular leak syndrome side effects but retaining its natural cytotoxicity, was adapted to the protein platform. The design was developed with the peptide T22 in the N-terminal, which binds CXCR4, and a his-tag in the C-terminal. This was combined with a furin cleavable site fragment in order to release the protein intracellularly, and a KDEL sequence to avoid endoplasmic reticulum secretion. Purified soluble CXCR4-targeted ricin A chain NPs with an average diameter of 11 nm, reached a 100-fold cytotoxic improvement with an IC50 of 13 ± 0.5 x 10 -9 M in HeLa cells. Also, insoluble 400-600 nm inclusion bodies were produced by recombinant methods and purified, with partial cytotoxic results. The receptor-dependent mechanism of T22-mRTA-H6 was verified and evaluated in an acute myeloid leukemia (AML) mouse model by systemic administration through a vein tail injection where an important blockage of the leukemic cells was verified without side systemic or histological toxicity in healthy organs. In a similar way, chlorotoxin (CTX) was also incorporated to the protein platform in order to take advantage of its targeting and therapeutic effect in glioblastoma (GBM), both functions in one peptide. Two versions that target protein Annexin-2 and the matrix metalloproteinase MMP-2 were engineered, namely CTX-GFP-H6 and CTX-KRKRK-GFP-H6. The soluble NPs of an average dimeter of 12 nm were incubated with HeLa cells, overexpressing annexin-2, and in U87MG cells, overexpressing MMP2. Both versions were fully fluorescent but CTX-GFP-H6 presented mild cytotoxic effects, whereas CTX-KRKRK-GFP-H6 showed to be more cytotoxic in U87MG cells than in HeLa cells. The selective affinity of CTX was confirmed by means of evaluating its targeting using a monoclonal antibody and a polyclonal serum against the cell surface protein, acting as a CTX receptor.
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Burns, Mary Elizabeth. "An exploration of the importance of self-care to the drama therapy intern." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0015/MQ54353.pdf.

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45

Eisner, Sharon R. Wood Julia T. "From destructive to constructive thinking techniques of self-therapy for adults with ADD /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,852.

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Thesis (M.A.)--University of North Carolina at Chapel Hill, 2007.
Title from electronic title page (viewed Dec. 18, 2007). "... partial fulfillment of the requirements for the degree of Master of Arts in the Department of Communication Studies." Discipline: Communication Studies; Department/School: Communication Studies.
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46

Bailey, Susannah Ines. "Self-inactivating retroviral vectors for gene therapy of X-Linked severe combined immunodeficiency." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444526/.

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X-Linked severe combined immunodeficiency (SCID-X1) is caused by mutations in the gene encoding the common cytokine receptor gamma chain, yc, resulting in profound defects in both cellular and humoral immunity. Although allogeneic bone marrow transplantation has proved highly successful, HLA-mismatched procedures are associated with significant morbidity and mortality. This disease is therefore a good candidate for gene therapy and sustained correction of 19 SCID-X1 patients have been reported in two clinical trials. However, the occurrence of severe adverse advents in one trial has highlighted the potential side-effects of retroviral gene transfer and reinforced the need to develop safer gene therapy vectors. A series of self-inactivating (SIN) gammaretroviral and lentiviral vectors for the treatment of SCID-X1 have consequently been developed. To reduce the potential for insertional mutagenesis mediated by the duplicated viral LTR sequences, alternative internal regulatory elements have been incorporated into the vector backbone. These include both endogenous (human elongation factor la - EFS) and viral (spleen focus forming virus - SFFV) promoters. In vitro, the SIN retroviral vectors were able to regulate yc expression on the cell surface of SCID-X1 cell lines and restore the lymphoid differentiation potential of Il2rg" haematopoietic progenitor cells. Functional correction of the immunological defect in the SCID-X1 mouse model was also achieved at similar levels for the both the SIN retroviral vectors and the LTR-regulated clinical vector. To further improve upon safety, lentiviral vectors were developed incorporating the endogenous human IL2RG promoter to regulate physiological expression of yc. In vitro and in vivo analysis of the promoter indicated a degree of haematopoietic tissue specificity and restoration of functional yc-receptor complexes was achieved following transduction of a SCID-X1 T cell line with a lentiviral vector incorporating this promoter however phenotypic correction of the yc-deficient mouse was unsuccessful. These results demonstrate that SIN retroviral vectors for SCID-X1 are effective in restoration of the immune defect in the yc-deficient murine model. The SIN design together with an endogenous (EFS) promoter might provide a potentially less mutagenic but equally effective vector for gene therapy of SCID-X1.
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47

Summers, Drayton T. "The effects of group therapy on a substance abuser's depression and self-esteem." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1997. http://digitalcommons.auctr.edu/dissertations/1864.

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This study examined the effectiveness of the use of group therapy as an intervention on the depression and self-esteem levels of a substance abuser. The study was based on the premise that participation in a group counseling setting would increase the clients self-esteem and decrease the client's depression. This study was conducted over a three-month period with instruments administered during each weekly session. The results indicated that the client experienced significant improvement in self-esteem as well as depression level.
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48

Smith, Brian Reed. "The examined life personal therapy and the social worker's ethical obligations to self /." Thesis, University of Iowa, 2008. http://ir.uiowa.edu/etd/16.

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49

Ierfino, Diana J. "An initial evaluation of an online compassion focused therapy intervention for self-esteem." Thesis, Canterbury Christ Church University, 2017. http://create.canterbury.ac.uk/16056/.

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To date, no research has evaluated the efficacy of a web-based Compassion Focused Therapy (CFT) intervention for young people. The current pilot study aimed to begin the process of evaluating the effectiveness and acceptability of a web-based CFT intervention by creating an online website youngmindbekind.com, and obtaining an initial effect-size estimate for a full scale randomised controlled trial (RCT) trial. A two-arm, pilot, RCT comparing a web-based CFT intervention to a waiting list control condition (WL) was carried out with young people aged 16 to 25 from a non-clinical population. Participants had asynchronous contact from the researcher once a week, solely via the internet, to provide instructions for modules. Self-report measures of self-esteem, self-compassion, mental health and quality of life were completed at baseline and post-intervention/wait-list. In addition, the intervention group received them again at a 4 week follow-up. A total of 40 participants were randomised to either web-based CFT (n=20) or to the WL group (n=20). Study attrition was 12 with 70% of participants completing the post-intervention/wait-list questionnaires. Pre-post change scores on all measures did not significantly differ between groups. The estimated, post-intervention, between groups, effect size for the primary outcome measure, namely the Rosenberg Self Esteem Scale, was d=0.17, with a 95% confidence interval of (0.92, 0.57). Qualitative feedback from questionnaires identified several themes relating to understanding compassion, activating compassion, finding the intervention acceptable, and future recommendations for the website. YoungMindBeKind.com appears to be an intervention capable of engaging young people. Given the relatively small effect size estimate, further pilot work to improve the intervention and/or target young people with lower self-esteem may be helpful prior to a full-scale RCT.
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50

Rosabal, Babette M. "Exploring Email Letter Writing To Augment Therapy Relationships With Clients Who Self-Injure." Thesis, Nova Southeastern University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10185671.

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The use of social technologies continues to grow at a rapid pace. Such technologies free individuals to communicate with one another in a multitude of ways without the need to be face-to-face in the same room This study was designed to explore, based on a small sample of case studies, the usefulness of one way that social technology is employed today, collaborative email letter writing (CELW), when used in conjunction with live therapy sessions to counsel a self-injuring population. Currently, most email counseling consists of exchanging communications without live clinical intervention (Heinlein, Welfel, Richmond, & Rack, 2003). While self-injury behavior (SIB) is on the rise (Conterio & Lader, 1998; Zila & Kiselica, 2001), there is little evidence that shows that either traditional or systemic postmodern therapies are useful in treating SIB in adolescents or young adults. Alternative forms of communication, such as letter writing (Freedman & Combs, 1996; White, 1995; White & Epston, 1990), have proven to benefit a variety of clients who have a difficult time expressing emotions in live therapy sessions. However, research studies on CELW as an ongoing therapeutic technique with clients are extremely limited. To address this gap, I conducted a qualitative case study on a small sample of clients in which I explored how CELW could be used with certain clients. Considering the in-depth understanding of the therapeutic participant-observer, therapist CELW, client CELW, and the researcher's experience, I sought to establish the meanings of multiple perspectives for analysis of this underused therapeutic technique. I used a cross-case analysis of three individual cases to provide both an in-depth understanding of the similarities and differences across three case studies, and to understand how clinicians might incorporate this additional resource into their clinical practices.

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