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Huang, Zhi, FuKun Hoffmann, Jeffrey Fay, Ann Hashimoto, and Peter Hoffmann. "Optimal signaling and effector functions induced by Fcγ-receptor engagement on macrophages require both selenoprotein K and high-avidity immune complexes (116.27)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 116.27. http://dx.doi.org/10.4049/jimmunol.186.supp.116.27.
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Abstract Selenoprotein K (Sel K) is an endoplasmic reticulum (ER) transmembrane protein that we have recently shown to play a role in calcium-dependent immune cell activation. Sel K-knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. In this study, we demonstrated that Sel K deletion resulted in decreased FcγR-mediated phagocytosis in mouse bone marrow derived macrophages (BMDM) compared to WT controls. To engage FcγR on BMDM, immune complexes (IC) were added comprised of either IgG-opsonized BSA (low avidity) or IgG-opsonized, BSA-coated beads (high avidity). Both types of IC induced Ca2+-dependent phosphorylation of ERK, but this was significantly decreased in Sel K-/- BMDM compared to controls. Nitric oxide (NO) was only induced with high avidity IC and was significantly decreased in Sel K-/- BMDM. PGE2, IL-6, and TNFα were induced by high avidity IC, but not low avidity IC, and were significantly reduced in Sel K-/- BMDM. Phagocytosis of high avidity IC produced lower oxidative burst in Sel K-/- BMDM. Consistent with this reduced oxidative burst, there was reduced destruction of IgG-opsonized West Nile virus in the phagolyzosome of Sel K-/- BMDM compared to controls. Overall, these results suggest that Sel K plays a role in FcγR-mediated signaling and effector functions of macrophages, and high avidity IC are required to induce maximal effects.
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Suyuthie HD, Harahap WA, Khambri D, and Rustam R. "Eksisi Luas dan Rekonstruksi Karsinoma Sel Basal Wajah di RSUP DR. M. Djamil Padang, Indonesia." Cermin Dunia Kedokteran 49, no. 1 (January 3, 2022): 27–31. http://dx.doi.org/10.55175/cdk.v49i1.185.
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Pembedahan adalah terapi paling efektif untuk karsinoma sel basal (KSB). Meskipun sangat jarang bermetastasis, KSB menyebabkan destruksi lokal luas mencakup kerusakan jaringan lunak, kartilago, dan tulang, sehingga memerlukan penanganan lebih komprehensif termasuk rekonstruksi. Tulisan ini melaporkan tata laksana kasus serial karsinoma sel basal di RSUP Dr. M. Djamil Padang periode Januari hingga Mei 2020.
Surgical treatment is the most effective treatment in basal cell carcinoma (BCC). Although metastasis is rarely found, basal cell carcinoma causes extensive local destruction including soft tissue, cartilage, and bone damage requiring more comprehensive treatment including reconstruction. A series of basal cell carcinoma cases management in Dr. M. Djamil General Hospital Padang during January to May 2020 was reported.
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HD, Suyuthie, Harahap WA, Khambri D, and Rustam R. "Eksisi Luas dan Rekonstruksi Karsinoma Sel Basal Wajah." Cermin Dunia Kedokteran 49, no. 1 (January 4, 2022): 27. http://dx.doi.org/10.55175/cdk.v49i1.1641.
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<p>Pembedahan adalah terapi paling efektif untuk karsinoma sel basal (KSB). Meskipun sangat jarang bermetastasis, KSB menyebabkan destruksi<br />lokal luas mencakup kerusakan jaringan lunak, kartilago, dan tulang, sehingga memerlukan penanganan lebih komprehensif termasuk<br />rekonstruksi. Tulisan ini melaporkan tata laksana kasus serial karsinoma sel basal di RSUP Dr. M. Djamil Padang periode Januari hingga Mei 2020.</p><p>Surgical treatment is the most effective treatment in basal cell carcinoma (BCC). Although metastasis is rarely found, basal cell carcinoma causes<br />extensive local destruction including soft tissue, cartilage, and bone damage requiring more comprehensive treatment including reconstruction.<br />A series of basal cell carcinoma cases management in Dr. M. Djamil General Hospital Padang during January to May 2020 was reported.</p>
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Widyatama, I. Ketut Hary, Edi Handoko, and Ahmad Dian Wahyudiono. "Hubungan kadar Interleukin-6 kolesteatoma dengan derajat kerusakan tulang pendengaran pasien otitis media supuratif kronis." Oto Rhino Laryngologica Indonesiana 44, no. 2 (April 7, 2015): 83. http://dx.doi.org/10.32637/orli.v44i2.89.
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Latar belakang: Kolesteatoma adalah lesi keratin non-neoplastik yang berhubungan dengan proliferasi sel epitel dengan karakteristik morfologi yang menyimpang. Otitis Media Supuratif Kronis (OMSK) yang disertai dengan adanya kolesteatoma dapat mengganggu keseimbangan antara pembentukan tulang dengan resorpsi tulang. Kolesteatoma dapat menghasilkan sitokin-sitokin seperti interleukin-6 (IL-6) yang berperan dalam proses destruksi tulang pendengaran. Tujuan: Mengetahui distribusi derajat kerusakan tulang pendengaran pada pasien OMSK dengan kolesteatoma, rerata kadar IL-6 pada kolesteatoma, dan adanya hubungan antara kadar IL-6 pada kolesteatoma dengan derajat kerusakan tulang pendengaran pada pasien OMSK dengan kolesteatoma. Metode: Penelitian ini melibatkan 6 pasien dengan OMSK dengan kolesteatoma yang dilakukan operasi mastoidektomi. Satu pasien menderita OMSK dengan kolesteatoma bilateral dan dilakukan operasi mastoidektomi pada kedua telinganya. Derajat kerusakan tulang pendengaran dinilai dengan menggunakan kriteria Saleh danMills, sedangkan kadar IL-6 pada kolesteatoma diukur dengan menggunakan instrumen ELISA. Hasil:Derajat kerusakan tulang pendengaran tertinggi yang ditemukan adalah derajat 3 (28,57%), sedangkan derajat kerusakan tulang pendengaran yang terbanyak adalah derajat 2 (42,86%). Kadar IL-6 pada kolesteatoma yang tertinggi adalah 2290 pg/mL, sedangkan rerata kadar IL-6 pada kolesteatoma adalah 1778,57±392,616 pg/mL. Kesimpulan: Kadar IL-6 pada kolesteatoma tidak berhubungan dengan derajat kerusakan tulang pendengaran pada pasien OMSK dengan kolesteatoma (p=0,885).Kata kunci: Kadar IL-6 kolesteatoma, derajat kerusakan tulang pendengaran, OMSK dengan koles-teatoma. ABSTRACTBackgrounds: Cholesteatoma is non neoplastic keratinized lesion related to epithelial cell proliferation with deviated morphologic characteristic. Chronic Suppurative Otitis Media (CSOM) with cholesteatoma may cause imbalance between bone formation and resorption. Cholesteatoma may produce cytokines such as interleukin-6 (IL-6) which has a role in ossicle destruction. Objectives: To evaluate the distribution of ossicle destruction degree in CSOM with cholesteatoma patients, mean of IL-6 level in cholesteatoma and the relationship between IL-6 level in cholesteatoma and ossicle destruction degree in CSOM with cholesteatoma patients. Methods: This study involved 6 CSOM with cholesteatoma patients who underwent mastoidectomy. One patient had bilateral CSOM with cholesteatoma and underwent mastoidectomy in both ears. Ossicle destruction degree was determined by using Saleh and Mills criterias whereas IL-6 level in cholesteatoma was measured by using ELISA kit. Results: The highest ossicle destruction degree was the third degree (28.57%), whereas the most common ossicle destruction degree was the second degree (42.86%). The highest IL-6 level in cholesteatoma was2290 pg/mL, whereas mean of IL-6 level in cholesteatoma was 1778.57 ± 392.616 pg/mL. Conclusions: IL-6 level in cholesteatoma didn’t have relationship with ossicle destruction degree in CSOM with cholesteatoma patients (p=0,885).Keywords: IL-6 level in cholesteatoma, ossicle destruction degree, CSOM with cholesteatoma.
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Nopy Arianti, Kadek, Made Oka Sastrawan, Fatur Reyhan Muradi, Muhammad Aflah, and Casvin Jus. "Wide eksisi dan flap rhomboid pada karsinoma basal sel regio facial." Intisari Sains Medis 13, no. 3 (November 16, 2022): 640–44. http://dx.doi.org/10.15562/ism.v13i3.1505.
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Background: Basal cell carcinoma is one of the most common classifications of non-melanoma skin cancer (75% - 80%) of all cancers. Basal cell carcinoma causes widespread local destruction including soft tissue, cartilage, and bone, thus impairing function and aesthetics, especially for the facial area. One of the most common reconstructive techniques for Basal Cell Carcinoma is the Rhomboid flap. This case report aims to report the use of the rhomboid flap reconstruction technique in post-wide excision of basal cell carcinoma. Case Description: A man, 54 years old, ethnic Balinese, came to the General Surgery Clinic of RSUD Klungkung with a complaint that a mole on the patient's left eye appeared enlarged with itching and bleeds easily. These complaints began to be felt since about 2 weeks before entering the hospital. Initially the patient's mole had been there for 5 years, previously the patient had no complaints about the mole, the initial lesion was in the form of a small brownish lump which was then felt to be getting bigger with itching and bleeding easily. The patient did not complain of pain. Examination of the localized status on the lateral periorbital sinistra showed blackish nodules with hyperpigmented macules, solitary, 2cm x 1cm in size, visible erosions, well-defined borders, irregular shape. Conclusion: The provisional diagnosis of Suspected Malignant Skin Tumor was established based on history, physical examination, with management therapy wide excision and reconstruction with Rhomboid Flap followed with biopsy. Latar Belakang : Karsinoma Sel Basal (KSB) adalah salah satu kanker kulit yang paling sering ditemukan dari seluruh kanker kulit non melanoma. Karsinoma Sel Basal dapat mengakibatkan kerusakan local dengan infiltrasi yang luas sehingga mengganggu fungsi dan estetika, terutama untuk daerah wajah. Salah satu pilihan teknik rekonstruksi yang bisa dilakukan pada Karsinoma Sel Basal di regio wajah adalah Rhomboid flap. Laporan kasus ini bertujuan untuk melaporkan penggunaan tehnik rekonstruksi dengan flap rhomboid pada pasca eksisi luas pada karsinoma sel basal. Deskripsi Kasus: Seorang laki-laki, 54 tahun, suku Bali, datang ke Poliklinik bedah Umum RSUD Klungkung dengan keluhan tahi lalat pada sebelah mata kiri pasien tampak membesar disertai gatal dan mudah berdarah. Keluhan tersebut mulai dirasakan sejak sekitar 2 minggu sebelum masuk RS. Awalnya tahi lalat pasien sudah ada sejak 5 tahun yang lalu, sebelumnya pasien tidak ada keluhan pada tahi lalat tesebut, lesi awal berupa benjolan kecil berwarna kecoklatan yang kemudian makin lama dirasakan makin membesar disertai rasa gatal dan mudah berdarah. Keluhan nyeri tidak dikeluhkan oleh pasien. Pemeriksaan status lokalis pada periorbital lateral S tampak nodul kehitaman disertai makula hiperpigmentasi, soliter, ukuran 2cm x 1cm, tampak erosi, batas tegas, bentuk tidak beraturan. Kesimpulan: Diagnosis sementara Tumor Kulit Suspek Malignant ditegakkan berdasarkan anamnesis, pemeriksaan fisik dengan terapi eksisi luas + biopsi + rekonstruksi dengan Rhomboid Flap.
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Chamdareno, Prian Gagani, and Hafiidh Nur Hidayat. "Studi Kelayakan Pengoperasian Chlorination Plant B Setelah Mengalami Kerusakan pada Liner 4 Busbar PT Indonesia Power Pro POMU." RESISTOR (Elektronika Kendali Telekomunikasi Tenaga Listrik Komputer) 4, no. 1 (May 22, 2021): 17. http://dx.doi.org/10.24853/resistor.4.1.17-22.
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Riset ini memiliki tujuan untuk menghitung efisiensi kinerja chlorination plant saat sebelum serta setelah transformasi dimodifikasi, serta membagikan saran terpaut pembedahan yang pas supaya bebas dari kehancuran. Kelayakan riset yang penulis gunakan adalah kualitatif dengan menggunakan metode deskriptif. Informasi dikumpulkan dengan mengamati parameter pembedahan chlorination plant serta observasi dan Analisa buku petunjuk. Hasil penelitian menunjukkan bahwa konsentrasi kaporit yang dihasilkan menurun setelah cell 4 mengalami kerusakan. Modus operasi dengan 3 sel masih layak dan pengoperasian terbilang aman.The aim of this research is to calculate the efficiency of chlorination plant performance before and after the modified transformation, and to provide appropriate surgical advice so that it is free from destruction. The feasibility of the research that the author uses is qualitative using descriptive methods. Information was collected by observing the surgical parameters of the chlorination plant as well as observation and analysis of the manual. The results showed that the concentration of chlorine produced decreased after cell 4 was damaged. The operating mode with 3 cells is still feasible and the operation is fairly safe.
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Yulvina, Yulvina, Bambang Hermani, Lisnawati Lisnawati, and Saptawati Saptawati. "Ekspresi tissue inhibitor metaloproteinase-2 pada metastasis kelenjar limfe leher pada karsinoma sel skuamosa laring." Oto Rhino Laryngologica Indonesiana 41, no. 2 (December 1, 2011): 135. http://dx.doi.org/10.32637/orli.v41i2.50.
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Background: Survival of laryngeal cancer cases depend on lymph nodes involvement. Tissue inhibitormetaloproteinase-2 (TIMP-2) has double effects on matrix metalloproteinase. TIMP-2 could inhibit orinduce metastasis process. Its expression depends on tumor location and histopathology. Purpose: Tofind out the presence of TIMP-2 on biopsy specimens of laryngeal squamous cell carcinoma and itsrelation to lymph node involvement. Methods: The immunoexpression of TIMP-2 was studied on biopsy specimens of 15 laryngeal carcinomas with lymph node metastasis and 18 patients without, collected between 2005-2009. Immunohistochemistry test were carried out in Pathology Department Universityof Indonesia using TIMP-2 (3A4) sc 21735 antibody from Santa Cruz. We used analytic-descriptivestudy to compare TIMP-2 expression between laryngeal squamous cell carcinoma with lymph node metastasis and those without. Results: The median of TIMP-2 immunoexpression in laryngeal squamouscell carcinoma in patients with lymph node involvement was 99 and the median in patients withoutlymph node metastases was 97, with range between 0-100. Statistical analysis revealed no significantdifference in TIMP-2 expression between groups with metastasis and without (p=0.403). Conclusions:Our results could not differentiate the TIMP-2 expression from patients with laryngeal squamous cellcarcinoma with lymph node metastasis and without. However, imbalances in the extracellular activitiesof matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases, linked to pathologicaltissue destruction, are more complex and need further investigation. Further study on correlationbetween TIMP-2 and MMP2-MT-1MMP immunoexpression is advised to determine its relationship tolymph node metastasis and to plan more aggressive treatment. Keywords: laryngeal squamous cell carcinoma, matrix metalloproteinase, tissue inhibitormetaloproteinase-2 Abstrak : Latar belakang: Angka harapan hidup pasien karsinoma laring ditentukan oleh adanya metastasiskelenjar leher. Tissue inhibitor metaloproteinase-2 (TIMP-2)mempunyai efek ganda pada kerja matriksmetalloproteinase yang merupakan salah satu penanda metastasis. TIMP-2 dapat menghambat ataumenginduksi metastasis. Ekspresi TIMP-2 tergantung pada lokasi dan jenis tumor. Tujuan: Melaporkanekspresi TIMP-2 pada sediaan biopsi karsinoma sel skuamosa laring dan hubungannya dengan metastasiskelenjar limfe leher. Metode: Ekspresi TIMP-2 diteliti pada 15 pasien karsinoma sel skuamosa laringdengan metastasis leher dan 18 pasien tanpa metastasis leher. Pemeriksaan imunohistokimia dilakukanpada jaringan biopsi yang diterima tahun 2005-2009. Imunohistokimia dilakukan sesuai dengan standarpemeriksaan di Departemen Patologi Anatomi FKUI menggunakan antibodi TIMP-2 (3A4) sc 21735 dariSanta Cruz. Penelitian bersifat analitik untuk melihat perbedaan ekspresi TIMP-2 antara karsinoma laringdengan metastasis leher dan yang tanpa metastasis leher. Hasil: Nilai median ekspresi TIMP-2 padakarsinoma laring dengan metastasis leher adalah 99 dan median TIMP-2 pada pasien tanpa metastasisleher adalah 97, dengan kisaran antara 0-100. Analisis statistik memperlihatkan tidak ada perbedaanbermakna pada ekspresi TIMP-2 antara kelompok karsinoma sel skuamosa laring dengan metastasisleher dan yang tanpa metastasis leher (p=0,403). Kesimpulan: Hasil penelitian ini menunjukkan ekspresiTIMP-2 tidak dapat dibedakan antara pasien yang bermetastasis leher dan yang tidak. Keseimbanganaktivitas antara matriks metalloproteinase (MMP) dan tissue inhibitors of matrix metalloproteinase(TIMP) berkaitan dengan destruksi patologis yang kompleks dan membutuhkan penelitian lebih lanjut.Disarankan pemeriksaan korelasi antara ekspresi TIMP-2 dan MMP2 serta dengan MT-1MMP dan_€Ó_x_,_nya dengan metastasis kelenjar limfe leher untuk memprediksikan terapi yang lebih agresif. Kata kunci: karsinoma sel skuamosa laring, matriks metalloproteinase, tissue inhibitor metaloproteinase-2
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Pinasti, Ladyamayu, Zenny Nugraheni, and Budiyanti Wiboworini. "Potensi tempe sebagai pangan fungsional dalam meningkatkan kadar hemoglobin remaja penderita anemia." AcTion: Aceh Nutrition Journal 5, no. 1 (May 20, 2020): 19. http://dx.doi.org/10.30867/action.v5i1.192.
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Anaemia occurs due to several factors, such as deficiency of iron, folic acid, vitamin B12 and protein. Anemia is directly caused by the lack of red blood cell production, the body loses blood either acutely or in a chronic manner, and the destruction of red blood cells is too fast. One of the prevention of anaemia by providing functional food that is developed is tempe which has high quality and nutritional value. The purpose of this study was to examine and analyze the potential of tempeh in increasing hemoglobin levels in patients with anaemia. This research is a literature review with a narrative method that studies and analyzes research results related to the potential of tempe to increase hemoglobin levels in patients with anaemia. The results of this study are the results of a literature review review which shows that Tempe contains an average of 2,0 mg of iron, folic acid 0,9-2,0 mg/kg according to the inoculum used and vitamin B12 raw tempe 0,08 μg/100 grams and cooked tempeh 0,14 μg/100 grams. The conclusion of this study states that tempeh has adequate nutritional value of protein, iron, vitamin B12, and folic acid, so that tempeh has the potential to increase hemoglobin levels in patients with anaemia. Expected, to be the basis of further research on genomics and genetic influences on human against tempe bioavailability as a functional food for adolescent anaemia. Anemia merupakan suatu keadaan jumlah sel darah merah atau kadar hemoglobin (Hb) dalam darah lebih rendah daripada nilai normal. Anemia terjadi karena beberapa faktor, diantaranya defisiensi besi, asam folat, vitamin B12 dan protein. Secara langsung anemia disebabkan kurangnya produksi sel darah merah, tubuh kehilangan darah baik secara akut atau menahun, dan hancurnya sel darah merah yang terlalu cepat. Salah satu pencegahan anemia dengan pemberian bahan pangan fungsional yang dikembangkan yaitu tempe yang mempunyai mutu dan nilai gizi tinggi. Tujuan penelitian adalah untuk mengkaji dan menganalisis potensi tempe dalam meningkatkan kadar hemoglobin pada penderita anemia. Penelitian merupakan literature review dengan metode naratif yang mengkaji dan menganalisis hasil penelitian yang terkait dengan potensi tempe untuk meningkatkan kadar hemoglobin pada penderita anemia. Hasil kajian menunjukkan bahwa Tempe mengandung rata-rata zat besi sebanyak 2,0 mg, asam folat 0,9-2,0 mg/kg sesuai dengan inoculum yang digunakan dan vitamin B12 tempe mentah 0,08 μg/100 gram dan tempe matang 0,14 μg/100 gram. Kesimpulan penelitian ini menyatakan tempe mempunyai nilai gizi zat besi, vitamin B12, dan asam folat yang cukup, sehingga tempe berpotensi untuk meningkatkan kadar hemoglobin pada penderita anemia. Penelitian ini diharapkan menjadi dasar penelitian lanjutan mengenai pengaruh genomik dan genetik pada manusia terhadap bioavabilitas tempe sebagai pangan fungsional untuk remaja anemia.
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Mahardhika, Gembong Satria. "Hyperglycemia Induced by COVID-19 with and without Present Diabetes: A Systematic Review." KELUWIH: Jurnal Kesehatan dan Kedokteran 2, no. 2 (June 30, 2021): 64–74. http://dx.doi.org/10.24123/kesdok.v2i2.4431.
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Abstract—COVID-19 is a major emerging disease that affects any certain condition. However, a recent report suggests the occurrence of hyperglycemia without any present diabetes in COVID-19 patients. This study aimed to systematically review recent evidence on hyperglycemia in COVID-19 patients. Literature research was done using four search engines, consist of Google Scholar, PubMed, ScienceDirect, and ProQuest, and limited to English manuscript only and published from February 2020 to September 2020. SARS-CoV-2 could damage the pancreas by causing the destruction of the β-cell structure that leads to impairment of glucose metabolism and worsen pre-existing diabetes or determine the appearance of hyperglycemia in non-diabetes. Inflammation also plays a major important role in hyperglycemia related to COVID-19. Hyperglycemia increased the vulnerability of the lung, by promoting and facilitating the entry of the SARS-CoV-2 into the host cells, and decreasing lung function. Moreover, the mortality and morbidity rate conceivable increased due to hyperglycemia. The presence of high glucose levels is linked with the progression of COVID-19 severity. Thus, the glucose level should be concerned, either in a patient with present diabetes or without any presence of diabetes. Examination and monitoring of glucose levels might be a useful tool to prevent the seriousness of COVID-19
Keywords: diabetes mellitus, SARS-CoV-2, high glucose level, pulmonary infection
Abstrak—COVID-19 adalah penyakit yang muncul yang mempengaruhi kondisi tertentu.Namun, sebuah laporan baru-baru ini menunjukkan terjadinya hiperglikemia tanpa adanya diabetes pada pasien COVID-19. Penelitian ini bertujuan untuk meninjau secara sistematis bukti terbaru tentang hiperglikemia pada pasien COVID-19. Penelitian literatur dilakukan dengan menggunakan empat mesin pencari, yaitu Google Scholar, PubMed, ScienceDirect, dan ProQuest, dan terbatas hanya pada manuskrip berbahasa Inggris dan diterbitkan dari Februari 2020 hingga September 2020. SARS-CoV-2 dapat merusak pankreas dengan menyebabkan kerusakan pada pankreas. struktur sel β yang menyebabkan gangguan metabolisme glukosa dan memperburuk diabetes yang sudah ada sebelumnya atau menentukan munculnya hiperglikemia pada kelompok non-diabetes. Peradangan juga memainkan peran penting utama dalam hiperglikemia terkait COVID-19. Hiperglikemia meningkatkan kerentanan paru-paru, dengan mendorong dan memfasilitasi masuknya SARS-CoV-2 ke dalam sel inang, dan menurunkan fungsi paru-paru. Selain itu, angka mortalitas dan morbiditas yang diperkirakan meningkat karena hiperglikemia. Adanya kadar glukosa yang tinggi dikaitkan dengan perkembangan keparahan COVID-19. Dengan demikian, kadar glukosa harus diperhatikan, baik pada pasien dengan diabetes saat ini atau tanpa adanya diabetes. Pemeriksaan dan pemantauan kadar glukosa mungkin menjadi alat yang berguna untuk mencegah derajat keparahan COVID-19.
Kata kunci: diabetes mellitus, SARS-CoV-2, peningkatan kadar glukosa, infeksi paru
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Bykova, G. I., and M. A. Grippas. "Specific formation of architecture under dynamics of natural and climatic changes in the Arctic region." Zemleustrojstvo, kadastr i monitoring zemel' (Land management, cadastre and land monitoring), no. 12 (December 2, 2021): 916–24. http://dx.doi.org/10.33920/sel-04-2112-06.
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The article reflects the issues of construction in the Arctic North. The authors underline the need to use climate information effectively to find the best solutions in preventing the coast and infrastructure destruction due to thawing permafrost and sea level rise. The paper offers the methods for adaptation the structures in the flood zone, for example, the construction methods of the facility: on a displacement base, on piles, inside a dam, on an island.
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Cahaya, Cindy, and Sri Lelyati C. Masulili. "Perkembangan Terkini Membran Guided Tissue Regeneration/Guided Bone Regeneration sebagai Terapi Regenerasi Jaringan Periodontal." Majalah Kedokteran Gigi Indonesia 1, no. 1 (June 1, 2015): 1. http://dx.doi.org/10.22146/majkedgiind.8810.
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Periodontitis adalah salah satu penyakit patologis yang mempengaruhi integritas sistem periodontal yang menyebabkan kerusakan jaringan periodontal yang berlanjut pada kehilangan gigi. Beberapa tahun belakangan ini banyak ketertarikan untuk melakukan usaha regenerasi jaringan periodontal, tidak saja untuk menghentikan proses perjalanan penyakit namun juga mengembalikan jaringan periodontal yang telah hilang. Sasaran dari terapi regeneratif periodontal adalah menggantikan tulang, sementum dan ligamentum periodontal pada permukaan gigi yang terkena penyakit. Prosedur regenerasi antara lain berupa soft tissue graft, bone graft, biomodifikasi akar gigi, guided tissue regeneration sertakombinasi prosedur-prosedur di atas, termasuk prosedur bedah restoratif yang berhubungan dengan rehabilitasi oral dengan penempatan dental implan. Pada tingkat selular, regenerasi periodontal adalah proses kompleks yang membutuhkan proliferasi yang terorganisasi, differensiasi dan pengembangan berbagai tipe sel untuk membentuk perlekatan periodontal. Rasionalisasi penggunaan guided tissue regeneration sebagai membran pembatas adalah menahan epitel dan gingiva jaringan pendukung, sebagai barrier membrane mempertahankan ruang dan gigi serta menstabilkan bekuan darah. Pada makalah ini akan dibahas sekilas mengenai 1. Proses penyembuhan terapi periodontal meliputi regenerasi, repair ataupun pembentukan perlekatan baru. 2. Periodontal spesific tissue engineering. 3. Berbagai jenis membran/guided tissue regeneration yang beredar di pasaran dengan keuntungan dan kerugian sekaligus karakteristik masing-masing membran. 4. Perkembangan membran terbaru sebagai terapi regenerasi penyakit periodontal. Tujuan penulisan untuk memberi gambaran masa depan mengenai terapi regenerasi yang menjanjikan sebagai perkembangan terapi penyakit periodontal. Latest Development of Guided Tissue Regeneration and Guided Bone Regeneration Membrane as Regenerative Therapy on Periodontal Tissue. Periodontitis is a patological state which influences the integrity of periodontal system that could lead to the destruction of the periodontal tissue and end up with tooth loss. Currently, there are so many researches and efforts to regenerate periodontal tissue, not only to stop the process of the disease but also to reconstruct the periodontal tissue. Periodontal regenerative therapy aims at directing the growth of new bone, cementum and periodontal ligament on the affected teeth. Regenerative procedures consist of soft tissue graft, bone graft, roots biomodification, guided tissue regeneration and combination of the procedures, including restorative surgical procedure that is connected with oral rehabilitation with implant placement. At cellular phase, periodontal regeneration is a complex process with well-organized proliferation, distinction, and development of various type of cell to form attachment of periodontal tissue. Rationalization of the use of guided tissue regeneration as barrier membrane is to prohibit the penetration of epithelial and connective tissue migration into the defect, to maintain space, and to stabilize the clot. This research discusses: 1. Healing process on periodontal therapy including regeneration, repair or formation of new attachment. 2. Periodontal specific tissue engineering. 3. Various commercially available membrane/guided tissue regeneration in the market with its advantages and disadvantages and their characteristics. 4. Recent advancement of membrane as regenerative therapy on periodontal disease. In addition, this review is presented to give an outlook for promising regenerative therapy as a part of developing knowledge and skills to treat periodontal disease.
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Handayani, Retno, and Erman Taer. "PENGARUH WAKTU AKTIVASI TERHADAP SIFAT FISIS DAN ELEKTROKIMIA SEL SUPERKAPASITOR DARI SABUT PINANG." Komunikasi Fisika Indonesia 16, no. 2 (October 31, 2019): 87. http://dx.doi.org/10.31258/jkfi.16.2.87-90.
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The Carbon electrodes made from areca husk biomass materials have been successfully prepared and characterized. Preparation of carbon electrodes start with the pre-carbonization process, destruction of pre-carbon samples by using Ball Milling and sieving carbon powder for resulting particle size of <53 µm. Pre-carbonized powder is chemically activated using a 0.5 M KOH activator and continued by pellet forming by using Hydraulic Press. The carbonization process was carried out at a temperature of 600 oC using N2 gas followed by physical activation by using CO2 gas with a temperature of 900 oC for 1.5 hours, 2 hours and 2.5 hours. Physical properties analyzed include density, morphological structure and elemental content. The electrochemical properties were analyzed using the cyclic voltammetry (CV) method. The best density analysis result after carbonization-activation is 0.664 in SP-2.5 sample. The highest specific capacitance as high as 17.9 F / g found in the SP-1.5 sample.
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Bykova, G. I., and M. A. Grippas. "Peculiarities of land development and construction in the Arctic region, given the dynamics of climate change." Zemleustrojstvo, kadastr i monitoring zemel' (Land management, cadastre and land monitoring), no. 6 (May 21, 2021): 1–7. http://dx.doi.org/10.33920/sel-04-2106-03.
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The article covers the specifics of land development and construction in the Arctic North. This requires the effective use of climate information to select optimal solutions for preventing unjustified overpricing of facilities, increased heat loss, low thermal resistance, and durability, affecting the overspending of capital investments. Recent trends in dynamic climate change leading to rising global sea levels, which could flood coastal areas of the Arctic seas, are considered. This can come along with the destruction of the coastal area and pose a great danger to infrastructure facilities.
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Bykova, G. I., and M. A. Grippas. "The features of land development and construction in the Arctic region, taking into account the dynamics of climatic changes." Zemleustrojstvo, kadastr i monitoring zemel' (Land management, cadastre and land monitoring), no. 6 (May 21, 2021): 425–31. http://dx.doi.org/10.33920/sel-4-2106-03.
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The article reflects the specifics of land development and construction in the Arctic North. It is necessary to use climate information effectively to select the best solutions and to avoid undue overestimation of the cost of facilities, increased heat loss, low heat resistance and strength affecting overspending. Recent trends in the context of dynamic climate change leading to rising sea levels, and possible flooding of coastal areas of the Arctic Seas are considered in this paper. The authors underline a great danger to infrastructure in result of possible destruction of coastal areas. English version of the article is available at URL: https://panor.ru/articles/peculiarities-of-land-development-and-construction-in-the-arctic-region-given-the-dynamics-of-climate-change/64263.html
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Gondo, Harry Kurniawan. "Pengaruh Serbuk Daun Kelor (Moringa oleifera) Terhadap Apoptosis Sel Hepar Pada Tikus Bunting Diabetes Mellitus." Jurnal Ilmiah Kedokteran Wijaya Kusuma 11, no. 1 (April 12, 2022): 12. http://dx.doi.org/10.30742/jikw.v11i1.1650.
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Maternal death rate in Indonesia are still very high. One of the causes is gestasional diabetes mellitus during pregnancy. Some of healing efforts are done, one of them was utilization of plants, in this case, Moringa oleifera. The purpose of this reseach is to know the Moringa oleifera leaf powder on the pregnant wistar rats with gestasional diabetes mellitus. The study design was laboratoric experimental on the wistar rats as the experimental animal, using Control Group Post Test Design on the research. Sample was divided into 2 positive and negative control groups and 4 treatment groups given Moringa oleifera leaf powder that will be induced by alloxan and the liver histopatological result be examined. Total average of liver cell nucleus that goes through apoptosis is lower linear with the increase of the Moringa oleifera leaf powder dose given to the treatment group. After the alloxan induction, the wistar rats’ blood glucose level is increased, caused by the destruction of the beta cell pancreas. There’s a significant difference between the liver cell that go through apoptosis between the four treatment group of wistar rats. The total average of liver cell that go through apoptosis is lower linear with the increase of the Moringa oleifera leaf powder dose given to the treatment group. Oral administration of Moringa leaf powder to white rats with diabetes mellitus was able to improve the histopathological picture of the liver where the brown color was seen to decrease while the methylene green increased. As well as lowering the blood glucose levels of the rats.
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Riani, Fety, and Ita Marlita Sari. "Laporan Kasus Karsinoma Sel Skuamosa yang Berkembang dari Papiloma Tipe Inverted Sinonasal pada Pekerja Pabrik Cermin." Sanus Medical Journal 3, no. 1 (February 28, 2022): 9–13. http://dx.doi.org/10.22236/sanus.v3i1.8103.
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Background. Sinonasal inverted (PI) papilloma is a benign tumor of the mucosal epithelium of the nasal cavity and paranasal sinuses with an endophytic growth pattern. PI is more common in men in the fifth and sixth decades of life. These tumors have local aggressive behavior, high recurrence rates, and can undergo malignant transformation. Squamous cell carcinoma (SCC) is the most common malignancy developed from sinonasal PI. SSC developed from PI (KSS/PI) is related to exposure in the work environment.
Methods. We report a sinonasal SCC/PI case by describing the clinical manifestations, radiological features, and histopathological features of a young male patient who was a non"‘smoker mirror"‘making factory worker.
Results. Clinical manifestations of pain, epistaxis, and proptosis in patients suggest malignancy. Computed Tomography (CT) results showed lesions of the nasal cavity and paranasal sinuses with bone destruction and expansion of the mass to the intracranial point of the aggressive behavior of the tumor. Microscopic histopathological examination revealed endophytic squamous epithelial growth characteristic of an inverted papilloma accompanied by cell atypia, invasive components, connective tissue desmoplasia, and keratin pearls, suggesting a well"‘differentiated keratinized squamous cell carcinoma that developed from the sinonasal inverted papilloma. Exposure to dust in the work environment is related to malignancy in this patient.
Conclusion. Support of clinical and radiological data, adequate sampling, and identification of malignancy morphology routinely on histopathological examination is critical to avoid misdiagnosis of sinonasal SCC/PI. A complete history directed at extracting risk factors can add value in establishing a diagnosis.
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Popov, N. A., and V. Yu Sidorova. "Biological diversity of forest plant communities as a feed resource for beef cattle breeding (review)." Kormlenie sel'skohozjajstvennyh zhivotnyh i kormoproizvodstvo (Feeding of agricultural animals and feed production), no. 7 (July 1, 2021): 3–17. http://dx.doi.org/10.33920/sel-05-2107-01.
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In the State Forest Fund and forests of rural territories of the Russian Federation the areas of hayfields and pastures are 4,3 and 2,3 million hectares. Annually, 22,5 million tons of herbage are harvested on forest lands, which is 4,5 million tons of hay. Forest soils of the Moscow region are characterized by high acidity, low content of nutrients, they need regular fertilization. In the Moscow region according to the type of soils they are divided into gray forest soils, which make up 6,1 % of all soils and sod-podzolic – 43,4 %. When livestock manure enters the soil during grazing, the pH of the soil becomes alkaline 8,0–9,0. Six-month compost of livestock manure with a moisture content of 80 %, left on forest pastures, exceeds the leaves’ litter in the amount of dry matter by 2,6 times, N (in % for absolutely dry matter) by 6,5 times, the amount of cement carbon (C) by 1,6 times, the amount of total nitrogen (N) by 16,8 times, but is inferior in the content of C (in % for absolutely dry matter) by 1,6 times. Deoxidation of soils promotes accelerated vegetation. The impact of livestock grazing on forest resources has both positive and negative effects on increasing the biodiversity of plant communities. Livestock grazing causes both harm and benefit to forest biological diversity. The harm is caused by unregulated use, the benefit of grazing brings as a source of organic fertilizers, restoring the cycle of C, P, N. Cattle also contributes to the loosening of the soil, the destruction of ticks, and it participates in the change of the plant composition of the forest to more valuable types of trees and shrubs.
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Mironov, D. A., I. V. Liskin, S. A. Sidorov, V. D. Nagorny, I. I. Afonina, and M. N. Kostomakhin. "Simulation of soil cutting blade wear." Sel'skohozjajstvennaja tehnika: obsluzhivanie i remont (Agricultural Machinery: Service and Repair), no. 10 (October 1, 2020): 61–68. http://dx.doi.org/10.33920/sel-10-2010-10.
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The results of a laboratory study of the wear patterns of blades of tillage parts are presented. To substantiate the model of soil-cutting blade wear in laboratory studies. Applied installation, providing rectilinear movement of the sample, one-time interaction of the blade with the particles of abrasive mass, and reproducing chip separation, inherent in most loamy soils. The dependence of the angle of inclination of the occipital chamfer to the bottom of the furrow, the width of the occipital chamfer and blade wear along the length of the sample from the cutting path, taken in studies for the main parameters of wear, were obtained. It was found that with increasing depth of cut, the intensity of wear increases, but when there are irregularities and undulations of the bottom of the furrow, it decreases due to the increase in the cutting path with lower loads due to the alternation of depressions and protrusions at the bottom of the furrow. With increasing hardness of the abrasive mass, the intensity of wear of the blade increases, at the same time the value of the stabilized angle of the occipital chamfer to the bottom of the furrow decreases, due to changes in the wear mechanism. With increasing cutting speed, the intensity of blade wear increases due to increased soil resistance forces and specific energy expended on its deformation and destruction. It was shown that the abrasive model of the soil corresponds to the real loamy soil for the study of wear of cutting elements. The expansion of the characteristics of the soil model peculiar to «nature» is due to the inclusion of additional components, in particular ceresin and vaseline, in the composition of the base "paraffin + quartz particles".
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Koshelev, S. N., N. V. Ponamarev, O. V. Romanova, N. M. Kostomakhin, and Yu A. Karmatskikh1. "Accumulations of technogenic emissions in the snow cover of the north-west in the Kurgan region." Kormlenie sel'skohozjajstvennyh zhivotnyh i kormoproizvodstvo (Feeding of agricultural animals and feed production), no. 8 (July 21, 2022): 3–13. http://dx.doi.org/10.33920/sel-05-2208-01.
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The study of the accumulation and spatial distribution of ecotoxicants on agricultural lands is one of the important aspects in solving the problem related to the environmental safety of animal feed and food products obtained. In this regard, there is a need to assess the content of pollutants in the chain atmosphere – snow cover. The purpose of the research was to assess the level of contamination of the snow cover of agricultural enterprises in the areas of the north-west of the Kurgan region exposed to man-made impacts. In the north-western part of the Kurgan region three variants of territories were identifi ed that diff er in the degree of environmental stress. The fi rst territory is experiencing the load from the nearby powerful South Ural industrial agglomeration, subject to transboundary man–made pollution, spreading both by water and aerogenically (Kataysky area); the second territory is the subject to transboundary man-made pollution by enterprises of the Chelyabinsk region, and is the location of facilities for the storage and destruction of chemical weapons (Shchuchansky area); the third territory is the territory of relative ecological well–being (Shadrinsky and Kargapolsky areas). In the areas of the north-west of the Kurgan region, the zonal nature of technogenic pollution of snow cover and soils has been revealed. Pollution of the studied territories occurs through the introduction of technogenic aerosols, as well as the influence of local sources. It was revealed that nitrites, nitrates, ammonium nitrogen, manganese make up the largest share in the association of pollution of the studied territories, while sulfates, chlorides and zinc make up the smallest share. In the snow cover, the highest concentration of heavy metals was detected in the fi rst and second territories. The third territory is subject to contamination by the studied elements to a lesser extent.
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Ponomarev, Sergey Vladimirovich, Olga Aleksandrovna Levina, Aliya Baymuratovna Akhmedzhanova, Yulia Viktorovna Fedorovykh, Valery Antonovich Pospelov, Evgeny Alexandrovich Dutikov, and Yulia Mikhailovna Shirina. "Evaluation of the effectiveness and productive effect of various dry combined feeds on the functional state of aquaculture objects under conditions of recircular systems." Rybovodstvo i rybnoe hozjajstvo (Fish Breeding and Fisheries), no. 5 (May 1, 2021): 48–63. http://dx.doi.org/10.33920/sel-09-2105-04.
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The shortage of fish feed of domestic production is one of the limiting factors for increasing the volume of fish production. The article analyzes the effectiveness of the use of granulated-extruded feed “BIFFINE” (Russia) in comparison with the extruded feed of the wellknown foreign brand “COPPENS” (the Netherlands) in the cultivation of African clary catfish and a hybrid of tilapia in a closed water supply system. The analysis of fish-breeding and biological indicators, as well as the assessment of the physiological state of the raised fish, was carried out. Comparative analysis of hematological and biochemical parameters of blood serum did not reveal significant differences. The evaluation of the feeding efficiency revealed slightly higher indicators of tilapia growth (p<0.05) and some physiological and biochemical parameters of the blood of the fish group that consumed Russian feed. The results of the study of white blood cells in the blood of the tilapia hybrid showed that the composition of white blood cells is dominated by lymphocytes (80.0–90.0%), monocytes (3.5–5.0%), neutrophils (6.5–11.0%) and basophils (0.5– 1.3%); a significant increase in glucose levels was found, which indicates the activation of the process of digestion of the carbohydrate part of the diet. In juvenile clary catfish, the stimulation of protein and glucose biosynthesis was noted, which indicates the optimization of protein and carbohydrate metabolism. Thus, when feeding fish with feed from different manufacturers, no differences were found in the functional state of the cultivated fish species. The tested brands of mixed feeds have a high nutritional value, which was confirmed by the obtained data of fishbreeding and biological indicators. However, it should be borne in mind that the technology of making mixed feed “BIFFINE” has the following advantage-soft processing of feed components of animal origin with the preservation of the native properties of protein, amino acids, fatty acids, vitamins and other essential nutrients, and the destruction of starch during hard processing by temperature and pressure to easily digestible carbohydrates, is performed separately.
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Temiraev, R., and M. Farnieva. "The influence of diets enriched with vitamin E and Hadox drug on the meat productivity of quails." Kormlenie sel'skohozjajstvennyh zhivotnyh i kormoproizvodstvo (Feeding of agricultural animals and feed production), no. 3 (March 1, 2020): 51–68. http://dx.doi.org/10.33920/sel-05-2003-05.
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In recent decades, the quail industry has become a promising direction in industrial poultry farming in our country. The basis of full-fledged compound feed of meat poultry is grain cereals (corn, barley, sorghum, etc.) and legumes (soy, peas, castor-oil plant, etc.). However, due to the high concentration of lipids in the grain of some of these crops and compound feed in general if storage in conditions are violated, feeding them to quails in large quantities can lead to the accumulation of peroxides in them and activation of lipid peroxidation processes in the body. The mechanism of action of antioxidants is to activate the body’s anti-radical defense, because these drugs are able to effectively prevent “oxidative stress” by neutralizing free oxygen radicals. Without antioxidants due to the high activity of free radicals in the bird’s body the processes of oxidation of phospholipids of cell membranes are activated, which leads to the destruction of the structure of the DNA molecule and gene mutations. Therefore, natural and synthetic feed preparations of antioxidants, which differ in synergism of action with a wide range of dietary additives on metabolic processes, have become more actively used in poultry nutrition. The purpose of the research was to study the influence of barley-sorghum-soy-type diets enriched with antioxidant preparations Hadox and vitamin E on meat productivity, nutritional and biological value of meat, the state of metabolism in the body of quails reared for meat. Under the conditions of the North Caucasus the expediency of joint feeding of feed antioxidants vitamin E and Hadox to quails grown for meat has been experimentally proved and scientifically justified, when using diets based on barley grain, sorghum and soy of local production, to increase meat productivity, increase their nutritional and biological value of meat and intensify metabolic processes. Thus, in order to increase the economic effectiveness of quail meat production in the North Caucasus the formulation of compound feed based on barley, sorghum and soy of local production should be input together the antioxidant preparations vitamin E at the dose of 25 thousand IU/t of feed and Hadox at the dose of 150 g/t of feed.
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Deeng, Gracia V. Y., Sekplin A. S. Sekeon, and Finny Warouw. "Manfaat Proloterapi pada Osteoartritis Lutut." e-CliniC 9, no. 1 (January 4, 2021). http://dx.doi.org/10.35790/ecl.v9i1.32479.
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Abstract: Osteoarthritis (OA) is calcification of the joint associated with severe painful sensation caused by joint instability. This joint instability is affected by destruction of cartilage that protects the bones. Osteoarthritis can be caused by various factors such as age, genetic as well as vigorous exercise or activity. As the cartilage destruction progresses, the unprotected bone will rub on the other bone in the joint which can lead to osteoarthritis. Management of OA consists of a variety of treatments, such as pharmacological, non-pharmacological, non-pharmacotherapy, and surgery treatments. Due to the development of science and technology, various modalities have emerged that can support the treatment of OA inter alia prolotherapy. Prolotherapy or regenerative injection could influence the recovery of the destructed area directly and relief the painful sensation through the actions of inflammatory cells, macrophages, immune cells, and cytokines, therefore, the improvement of the destructed areas could occur faster. It was reported that knee osteoarthritis could be treated with prolotherapy successfully. In conclusion, since prolotherapy influences the body to repair the destructed areas, hence it could be used as the new osteoarthritis treatment, especially knee osteoarthritis.Keywords: prolotherapy, knee osteoarthritis, chronic pain Abstrak: Osteoartritis (OA) merupakan pengapuran sendi yang disertai nyeri hebat, disebabkan oleh karena adanya ketidakstabilan sendi yang dipengaruhi oleh rusaknya tulang rawan yang berperan untuk melindungi tulang. Osteoartritis dapat disebabkan oleh berbagai faktor seperti usia, jenis kelamin, genetik, aktivitas maupun olahraga berat. Saat tulang rawan rusak, maka tulang yang tidak dilindungi dapat saling bersinggungan di sendi sehingga sendi hancur dan berujung pada OA. Pengobatan untuk OA terdiri dari beragam pengobatan baik farmakologi, non-farmakologi, non-farmakoterapi, maupun tindakan operasi. Seiring berjalannya perkembangan ilmu pengetahuan dan teknologi, maka muncul berbagai modalitas yang dapat menunjang pengobatan OA, antara lain proloterapi. Proloterapi atau injeksi regeneratif memengaruhi dan memberi dampak penyembuhan secara langsung pada area yang mengalami cedera maupun nyeri melalui kerja sel-sel radang, makrofag, sel-sel imun, dan sitokin sehingga dapat bekerja lebih cepat untuk perbaikan daerah yang cedera. Telah dilaporkan hasil bermakna dalam peng-gunaan proloterapi pada osteoartritis lutut. Simpulan penelitian ini ialah proloterapi merangsang tubuh untuk memperbaiki daerah yang cedera sehingga merupakan solusi terbaik yang dibutuhkan dalam pengobatan OA dewasa ini terutama pada OA lutut.Kata kunci: proloterapi, osteoartritis lutut, nyeri kronik
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Anver, Gregorius F., Max F. J. Mantik, and Jeanette I. Ch Manopo. "Gambaran Klinis Diare pada Pasien Anak Leukemia Limfoblastik Akut dengan Kemoterapi." e-CliniC 5, no. 1 (January 18, 2017). http://dx.doi.org/10.35790/ecl.5.1.2017.14764.
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Abstract: Chemotherapy is usually used in acute lymphoblastic leukemia (ALL) patients to kill the neoplasmic cells. Albeit, this chemotherapy also destroys normal cells in the body. One of the complications of chemotherapy is destruction of digestive mucous cells that results in diarrhea. Diarrhea can cause dehydration, hypokalemia, acidosis that could lead to shock as well as death. This study was aimed to obtain the clinical profile of diarrhea in children with ALL treated with chemotherapy. This was a descriptive retrospective study with a cross sectional design using 60 medical records of children with ALL treated with chemotherapy and suffered from diarrhea in Estella room at Pediatrics Department Prof. Dr. R. D. Kandou Hospital in 2011-2015. Conclusion: In this study, there were only a fiew ALL patients treated with chemotherapy that got diarrhea. Diarrhea associated with blood and vomiting was very minimal meanwhile diarrhea associated with fever occured in some cases.Keywords: acute lynphoblastic leukemia, chemotherapy diarrhea Abstrak: Kemoterapi merupakan salah satu metode pengobatan yang sering digunakan pada penderita leukemia limfoblastik akut (LLA) untuk membunuh sel neoplasma. Dilain pihak kemoterapi tidak hanya membuhuh sel-sel leukemia tetapi juga menyerang sel-sel normal. Salah satu contoh efek samping kemoterapi yaitu kerusakan sel mukosa saluran cerna yang menyebabkan diare. Hal ini dapat mengakibatkan terjadinya dehidrasi, hipokalemia dan asidosis yang tidak jarang berakhir dengan syok dan kematian. Penelitian ini bertujuan untuk mengetahui gambaran klinis diare pada pasien anak dengan LLA yang menjalani kemoterapi. Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang yang dilakukan pada 60 data rekam medik pasien anak yang mengidap LLA dengan kemoterapi dan disertai diare di Pusat Pengobatan Kanker Ruang Estella Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou pada tahun 2011-2015. Simpulan: Pada penelitian ini hanya sebagian kecil pasien LLA dengan kemoterapi yang mengalami diare. Kejadian diare yang disertai darah dan muntah sangat rendah, sedangkan kejadian diare yang disertai demam hanya terjadi pada sebagian anak.Kata kunci: leukemia limfoblastik akut, kemoterapi, diare
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Lintong, Fransiska. "GANGGUAN PENDENGARAN AKIBAT BISING." JURNAL BIOMEDIK (JBM) 1, no. 2 (February 6, 2013). http://dx.doi.org/10.35790/jbm.1.2.2009.815.
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Abstract: Noise induced hearing loss is often found among industrial workers all over the world, especially in developing countries, such as Indonesia. The permitted maximum limit of noise for a human being is 80 dB. Noise with a high intensity that occurs for a long time can cause some changes in metabolic processes and the blood supply in the organ of Corti. The impacts of these changes are damage and degeneration of hair cells, and in the long run, the total destruction of this organ and permanent hearing loss. Effects of noise to this sense organ are in the forms of acoustic trauma, noise-induced temporary threshold shift, and noise-induced permanent threshold shift. Noise induced hearing loss is a senso-neural deafness, and is generally bilateral. Key words: noise, organ of Corti, permanent loss, senso-neural deafness Abstrak: Gangguan pendengaran akibat bising sering dijumpai pada pekerja industri di seluruh dunia, terlebih lagi di negara berkembang seperti Indonesia. Ambang batas maksimum aman dari bising bagi manusia adalah 80 dB. Bising dengan intensitas tinggi yang berlang-sung dalam waktu lama akan menyebabkan perubahan metabolisme dan vaskuler. Sebagai akibat terjadi robekan sel-sel rambut organ Corti dan kerusakan degeneratif sel-sel tersebut, yang kemudian berlanjut dengan destruksi total dari organ tersebut dan kehilangan pen-dengaran yang permanen. Efek bising terhadap pendengaran dapat berupa trauma akustik, perubahan ambang pendengaran akibat bising yang berlangsung sementara, dan perubahan ambang pendengaran akibat bising yang berlangsung permanen. Gangguan pendengaran yang terjadi akibat bising adalah berupa tuli senso-neural yang biasanya bilateral. Katakunci: Kebisingan, organ corti, permanen, tuli senso-neural
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Pelealu, Olivia C. P. "MEKANISME IMUN TERBENTUKNYA KOLESTEATOMA." JURNAL BIOMEDIK (JBM) 4, no. 2 (January 31, 2013). http://dx.doi.org/10.35790/jbm.4.2.2012.757.
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Abstract: Chronic suppurative otitis media associated with cholesteatoma is still a problem that causes high morbidity and mortality. That is due to the cholesteatoma destruction of surrounding bony structures that leads to fatal complications. Cholesteatoma acts benign but is a destructive middle ear tumor. It is characterized by hyperproliferative keratinocytes associated with a progressive and destructive accumulation of desqumated epithelia and keratin in the middle ear or other parts of temporal bones with pneumatization. There are four theories of cholesteatoma: invagination, invasion, metaplasia, and implantation. The main mechanisms of bone destruction are mechanical due to a pressure effect, biochemical factors, and cellular factors related to both innate and adaptive immunities. These immune responses are regulated by immune cells, cytokines, adhesive molecules, degrading enzymes, and osteoclasts.Key words: cholesteatoma, proliferative, bone resorption, cytokines, osteoclastAbstrak: Otitis media supuratif kronis dengan kolesteatoma masih merupakan masalah penyebab morbiditas dan mortalitas yang cukup tinggi. Hal ini disebabkan karena kolesteatoma dapat menyebabkan destruksi tulang sekitarnya, sehingga mudah mengakibatkan komplikasi fatal. Kolesteatoma menyerupai tumor jinak telinga tengah tetapi bersifat destruktif. Kelainan ini ditandai oleh adanya hiperproliferasi keratinosit disertai akumulasi deskuamasi epitel atau keratin di dalam telinga tengah atau bagian lain tulang temporal yang berpneumatisasi, yang bersifat progresif dan destruktif. Terdapat empat teori pembentukan kolesteatoma yaitu metaplasi, invaginasi, invasi, dan implantasi. Terjadinya destruksi tulang melalui faktor mekanis akibat efek penekanan, faktor biokimia, dan faktor seluler yang berkaitan dengan respon imun alamiah maupun adaptif yang diatur oleh sel-sel imun, sitokin, molekul adhesif, enzim degradasi, dan osteoklas.Kata kunci: kolesteatoma, proliferasi, resorbsi tulang, sitokin, osteoklas
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Lintong, Poppy M., Carla F. Kairupan, and Priska L. N. Sondakh. "GAMBARAN MIKROSKOPIK GINJAL TIKUS WISTAR (RATTUS NORVEGICUS) SETELAH DIINDUKSI DENGAN GENTAMISIN." JURNAL BIOMEDIK (JBM) 4, no. 3 (February 4, 2013). http://dx.doi.org/10.35790/jbm.4.3.2012.800.
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Abstract: Gentamycin, a frequently used aminoglycoside antibiotics, has a nephrotoxic effect to human beings and animals. The purpose of this research was to find out the microscopic changes of wistar rat kidneys after gentamycin induction. This was an experimental study, using five adult wistar rats, divided into three groups. Group I was the control group; group II consisted of two rats, injected with gentamycin 0,3 ml/day (dose of 60 mg/kg body weight/day) intraperitoneally for seven days; and group III consisted of two rats, injected with gentamycin 0,3 ml/day intraperitoneally for 10 days. Group I and II were terminated at day-8, and group III at day-11. Their kidneys were processed for microscopic slides, stained with hematoxylin eosin and Periodic Acid Schiff. In microscopic evaluation, group II and III showed oedema, necrosis, apoptosis, and basal membrane destruction of tubular epithelial cells. Group III also showed fat vacuoles in these epithelial cells (macrovesicular fatty changes). Conclusion: wistar rats injected with gentamycin 60 mg/kg body weight/day for 7 and 10 days showed oedema, necrosis, apoptosis, and basal membrane destruction of tubular epithelial cells; and macrovesicular fatty changes after 10 days of gentamycin.Key words: gentamycin, necrosis tubular epithelial cells, fatty changesAbstrak: Gentamisin termasuk antibiotik golongan aminoglikosida berspektrum luas yang bersifat nefrotoksik terhadap manusia dan hewan. Tujuan penelitian ini untuk melihat perubahan mikroskopik struktur ginjal tikus Wistar setelah diberikan gentamisin. Metode penelitian eksperimental dengan menggunakan lima ekor tikus Wistar dewasa yang dibagi atas tiga kelompok. Kelompok I tanpa perlakuan; kelompok II terdiri dari dua ekor tikus perlakuan yang diinjeksi dengan gentamisin 0,3 ml/hari (dosis 60 mg/kgBB/hari) secara intraperitonial selama tujuh hari; dan kelompok III terdiri dari dua ekor tikus perlakuan yang diinjeksi dengan gentamisin 0,3 ml/hari secara intraperitonial selama 10 hari. Tikus Wistar kelompok I dan II diteminasi hari ke-8, sedangkan kelompok III diterminasi hari ke-11. Ginjal tikus kelompok I -III kemudian dibuat preparat histopatologik dengan pengecatan rutin hematoksilin eosin dan Periodic Acid Schiff (PAS). Hasil penelitian menunjukkan tikus Wistar perlakuan yang diberikan gentamisin 0,3 ml/hari selama 7 sampai 10 hari secara mikroskopik memperlihatkan pembengkakan, nekrosis, apoptosis, dan destruksi membrana basalis sel epitel tubulus; dan pada hari ke-10 terlihat vakuol-vakuol lemak pada sel epitel sehingga inti terdesak ke tepi (perlemakan makrovesikuler). Simpulan: pemberian gentamisin pada tikus Wistar dengan dosis 60 mg/kg BB/hari selama 7-10 hari menunjukkan pembengkakan, nekrosis, apoptosis sel epitel tubulus, dan membrana basalis tubulus rusak; dan setelah hari ke-10 juga terlihat perlemakan makrovesikuler.Kata kunci: gentamisin, nekrosis sel epitel tubulus, perlemakan makrovesikuler
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Wangko, Sunny. "RABDOMIOLISIS." JURNAL BIOMEDIK (JBM) 5, no. 3 (April 16, 2014). http://dx.doi.org/10.35790/jbm.5.3.2013.4336.
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Abstract: Literally, rhabdomyolysis is the occurence of skeletal muscle destruction, resulting in massive liberation of muscle fiber constituents (electrolytes, myoglobin, creatine kinase, and other sarcoplasmic proteins) into the extracellular fluid and the blood circulation. The etiological spectrum of rhabdomyolysis is extensive, consisting of: physical factors such as trauma and compression, ischemia of skeletal muscle tissue, strenuous physical exercise, prolonged immobilization, high-voltage electrical injury, hyperthermia; and non-physical factors such as metabolic myopathy (genetic disorders), drugs and toxins, viral and bacterial infections, electrolyte and endocrin abnormalities, connective tissue disorders; and unknown causes. Although the causes of rhabdomyolysis vary extensively, the histopathological findings usually show a loss of cell nuclei and muscular striation with the absence of inflammatory cells. The pathophysiology of rhabdomyolysis includes changes in cellular metabolism, reperfusion injury, and the compartment syndrome. The degrees of rhabdomyolysis vary from a subclinical rise of creatinine kinase to an emergency condition with multiorgan failure. Classically, the clinical findings are muscular aches and swelling, as well as dysfunction, stiffness, numbness, weakness, and tea-colored urine. The most important laboratory examinations are serum creatinine kinase, besides serum and urine myoglobin. The life-threatening complications of rhabdomyolysis are hypovolemia, arrhythmia and cardiac arrest, acute kidney injury, and DIC. Its early diagnosis and prompt management are very important to the progress of the patient as well as to the effective control of rhabdomyolysis. Medical personnel, pharmacists, sport/gym instructors, and athletes have to be aware of the signs and symptoms of this rhabdomyolysis. Keywords: rhabdomyolysis, electrolytes, myoglobin, creatine kinase Abstrak: Rabdomiolisis adalah terjadinya destruksi serat otot rangka yang berakibat terlepasnya konstituen serat otot (elektrolit, mioglobin, kreatin kinase, dan protein sarkoplasma lainnya) ke dalam cairan ekstrasel dan sirkulasi. Penyebab rabdomiolisis multifaktorial, terdiri dari: faktor fisik, antara lain trauma dan kompresi, iskemia jaringan otot, latihan fisik berat, imobilisasi berkepanjangan, paparan listrik bertegangan tinggi, hipertermia; faktor non-fisik, antara lain miopati metabolik (genetik), obat-obatan dan toksin, infeksi virus dan mikroba, gangguan elektrolit dan endokrin, kelainan jaringan ikat; dan penyebab yang tidak diketahui. Walaupun penyebab rabdomiolisis sangat bervariasi, gambaran histologik yang ditemukan umumnya berupa hilangnya inti serat otot dan corak serat, tanpa disertai adanya sel-sel radang. Patofisiologi rabdomiolisis yaitu perubahan metabolisme sel, cedera reperfusi, dan sindroma kompartemen. Derajat rabdomiolisis dapat bervariasi dari peningkatan kreatin kinase subklinis sampai yang memerlukan penanganan darurat disertai kegagalan multiorgan. Gejala klinis klasik berupa nyeri, pembengkakan dan disfungsi otot, kaku, kesemutan, kelemahan, serta urin berwarna teh. Pemeriksaan penunjang utama yaitu kreatin kinase serum, serta miogobin urin dan serum. Komplikasi yang sangat mengancam kehidupan ialah hipovolemia, aritmia dan gagal jantung, gagal ginjal akut, serta DIC. Diagnosis dini dan penanganan segera sangat berperan dalam perlangsungan rabdomiolisis dan prognosis pasien. Tenaga medis, tenaga farmasi, instruktur olah raga dan gym perlu diwaspadai terhadap gejala rabdomiolisis. Kata kunci: rabdomiolisis, elektrolit, mioglobin, kreatin kinase
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Wijaya, Yoczhan A., Sonny J. R. Kalangi, and Martha M. Kaseke. "GAMBARAN REAKSI RADANG LUKA POSTMORTEM PADA HEWAN COBA." Jurnal e-Biomedik 3, no. 1 (February 7, 2015). http://dx.doi.org/10.35790/ebm.3.1.2015.8301.
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Abstract: Skin is the most outer organ of human body which is very vulnerable to be injured. Injuries or wounds are destruction of the unity/components of tissues with damaged or missing of specific tissues. Normally, the body will respond to any injury/wound with the occurence of inflammatory process. Albeit, this inflammatory process does not only occur in living body; it can be microscopically identified in postmortem state. This study aimed to identify the inflammatory process microscopically in experimental animal postmortem. This was a descriptive experimental study. One local pig weighing 15 kg was used as model. Incised wounds were made on the lateral side of its abdomen with an interval of 1 hour from 0 to 12 hours postmortem. Tissues of 0-11 hour postmortem wounds were taken with a transversal excision at 12 hours postmortem. Tissues of 3, 6, 9, and 12 hour postmortem wounds were taken at 24 hours postmortem. The results showed that inflammatory process with increased number of PMN leucocytes in the dermis could be identified until 3-5 hours postmortem. However, since 6 hours postmortem the PMNs’ number had decreased. Conclusion: Inflammatory process of wounds could be identified until 3-5 hours postmortem.Keywords: injury/wound, inflammatory processAbstrak: Kulit merupakan organ tubuh terluar yang paling rentan terhadap terjadinya luka dibandingkan organ lainnya. Luka merupakan rusaknya kesatuan/komponen jaringan dimana secara terdapat substansi jaringan yang rusak atau hilang. Secara normal tubuh akan berespon terhadap cedera melalui proses radang yang terjadi baik saat masih hidup maupun setelah kematian yang dapat diamati secara mikroskopik. Penelitian ini bertujuan untuk mengetahui gambaran mikroskopik reaksi radang luka setelah kematian (postmortem) yang diamati pada beberapa interval waktu sampai 24 jam postmortem dengan menggunakan hewan coba. Penelitian ini bersifat deskriptif eksperimental. Sampel penelitian menggunakan 1 ekor babi domestik dengan berat 15 kg. Luka insisi dibuat pada sisi lateral abdomen setiap interval 1 jam dimulai dari 0 jam sampai 12 jam postmortem. Untuk luka 0-11 jam postmortem dilakukan pengambilan jaringan dengan potongan melintang terhadap garis luka setelah 12 jam postmortem. Untuk luka 3, 6, 9, 12 jam dilakukan pengambilan jaringan 24 jam postmortem. Hasil penelitian menunjukkan bahwa reaksi radang ditandai oleh bertambahnya populasi leukosit PMN pad dermis dapat diamati sampai 3-5 jam postmortem. Sejak 6 jam postmortem jumlah sel-sel radang terlihat berkurang. Simpulan: Reaksi radang pada luka postmortem masih ditemukan sampai 3-5 jam postmortem.Kata kunci: luka, reaksi radang
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Theodore, Victori J., Sunny Wangko, and Sonny J. R. Kalangi. "Gambaran histologik usus halus pada hewan coba selama 24 jam postmortem." Jurnal e-Biomedik 5, no. 1 (January 18, 2017). http://dx.doi.org/10.35790/ebm.5.1.2017.14804.
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Abstract: Studies about histological changes in small intestine are still very limited. This study was aimed to obtain the histological changes of the small intestine in several time intervals during 24 hours postmortem. This was a descriptive observational study using domestic pig as model. Samples were obtained from the ileum section of the small intestine, taken at 0 hour, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, 12 hours, 14 hours, 16 hours, 18 hours, 20 hours, 22 hours, and 24 hours postmortem. The results showed that the earliest histological change was identified at 0 hours postmortem as congestion of the intestinal glands and formation of subepithelial cell spaces, followed by destruction of basal membranes of the glands at 3 hours postmortem, lysis of the glands at 16 hours postmortem. At 18-24 hours postmortem, almorst all intestinal glands could not be identified. Conclusion: The earliest histological change of small intestine was identified at 0 hours postmortem as congestion of the intestinal glands, followed by necrosis of the glands at 3 hours postmortem, and lysis of the glands at 16 hours postmortem.Keywords: small intestine, autolysis, histological changes, postmortem Abstrak: Studi mengenai perubahan gambaran histologik usus halus postmortem masih sangat terbatas. Penelitian ini bertujuan untuk mendapatkan gambaran histologik usus halus berdasarkan variasi waktu selama 24 jam postmortem. Jenis penelitian ialah deskriptif observasional dengan menggunakan babi domestik sebagai hewan coba. Sampel diambil dari bagian ileum usus halus pada interval waktu: 0 jam, 1 jam, 2 jam, 3 jam, 4 jam, 5 jam, 6 jam, 7 jam, 8 jam, 9 jam, 12 jam, 14 jam, 16 jam, 18 jam, 20 jam, 22 jam, dan 24 jam postmortem. Hasil penelitian ini memperlihatkan bahwa perubahan histologik usus halus babi mulai teridentifikasi pada 0 jam postmortem berupa kongesti kelenjar intestinal, diikuti oleh kerusakan struktur membran basalis kelenjar pada 3 jam postmortem, dan lisis sel-sel kelenjar pada 16 jam postmortem. Pada 18-24 jam postmortem, hampir seluruh kelenjar intestinal tidak dapat diidentifikasi. Simpulan: Perubahan histologik awal dari usus halus dapat diidentifikasi pada 0 jam postmortem berupa kongesti kelenjar intestinal, diikuti oleh kerusakan struktur membran basalis 3 jam postmortem, dan lisis kelenjar pada 16 jam postmortem. Kata kunci: usus halus, autolisis, postmortem, waktupostmortem, perubahan histologik postmortem
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Halim, Elysia Veronica. "PENGARUH LATIHAN ZUMBA TERHADAP KADAR HEMOGLOBIN." Jurnal e-Biomedik 2, no. 1 (February 13, 2014). http://dx.doi.org/10.35790/ebm.2.1.2014.4552.
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Abstract: Hemoglobin is a conjugated protein, function to transport oxygen and carbon dioxide. Hemoglobin levels could be influence of some factors such as gender, iron (Fe) and exercise. Zumba is a Latin-inspired dance workout first developed in Columbia. This study have a purpose to find out the influence of zumba exercise on hemoglobin levels. This was an experimental study with one group pre and post test design, samples included 20 female students year 2013 Medical Faculty of Nursing Science Sam Ratulangi University who met the inclusion criterias. Data were analyzed by paired t-test using SPSS. There were 20 subjects in this study. The results showed that there was a decrease of hemoglobin level after zumba exercise for two weeks. Conclusion: Decrease of hemoglobin levels can caused from some factors that were iron loss during exercise through sweat, destruction on hemoglobin because mechanic stress on muscles and sport anemia.Keywords: Zumba, hemoglobinAbstrak: Hemoglobin adalah sebuah protein yang terkonjugasi, berfungsi untuk mentranspor oksigen dan karbon dioksida. Kadar hemoglobin dapat dipengaruhi oleh beberapa faktor seperti jenis kelamin, zat besi (Fe) dan olahraga. Zumba merupakan latihan tari Latin yang terinspirasi pertama kali dan dikembangkan di Columbia.Penelitian ini bertujuan untuk mengetahui pengaruh latihan zumba terhadap kadar hemoglobin. Penelitian ini bersifat eksperimental dengan rancangan one group pre and post test dengan jumlah sampel 20 mahasiswi Program Studi Ilmu Keperawatan angkatan 2013 Universitas Sam Ratulangi Manado yang memenuhi kriteria. Data dianalisis dengan uji t berpasangan menggunakan SPSS. Berdasarkan penelitian yang telah dilakukan pada 20 subjek penelitian diperoleh hasil yaitu terjadi penurunan kadar hemoglobin setelah melakukan latihan zumba selama dua minggu. Simpulan: Penurunan kadar hemoglobin dapat disebabkan beberapa faktor yaitu kehilangan zat besi selama latihan melalui keringat, hematuria akibat rusaknya sel darah merah karena stres mekanik pada otot dan sport anemia.Kata kunci: Zumba, hemoglobin
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Rinarto, Nisha Dharmayanti. "Faktor Risiko Kerusakan Sel Beta Pankreas Melalui Deteksi Antibodi Gad (Glutamic Acid Decarboxylase) 65 pada Perempuan di Stikes Hang Tuah Surabaya." Jurnal Ilmiah Keperawatan Stikes Hang Tuah Surbaya 12, no. 1 (January 22, 2019). http://dx.doi.org/10.30643/jiksht.v12i1.42.
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Pancreatic beta cell damage is irreversible due to ongoing oxidative stress on the formation of ROS underlying pathophysiology of the phase-onset diabetes mellitus. Prevention of damage to pancreatic beta cells in diabetes mellitus onset phase through the detection of GAD 65 as an autoantigen imonogenik diabetes mellitus in human pancreas reacts with GADA can be done early. The purpose of this study analyzed the age, physical activity, cholesterol, body mass index, and waist circumference as a risk factor in the positive expression of GAD 65 women's groups in serum STIKES Hang Tuah Surabaya. This study was cross sectional study. Samples are some women in STIKES Hang Tuah Surabaya as much 40 respondents who meet the inclusion and exclusion criteria were selected through probability sampling techniques. The result of the relationship with the independent variable dependent variable using Chi Square showed that age (p = 0.395), physical activity (p = 0.572), BMI (p = 0.388), and waist circumference (p = 0.411) so it is not a risk factor for damage pancreatic beta cells. While cholesterol (p = 0.035) so it is a risk factor for pancreatic beta cell destruction. The conclusion of this study was in women aged 19-37 years with risk factors that can be used as a prediction of pancreatic beta cell destruction via antibody detection GAD 65 is high cholesterol.Keywords: Pancreatic Beta Cell Destruction, GAD 65, Women