Academic literature on the topic 'Sel-Destruction'

Abstract Selenoprotein K (Sel K) is an endoplasmic reticulum (ER) transmembrane protein that we have recently shown to play a role in calcium-dependent immune cell activation. Sel K-knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. In this study, we demonstrated that Sel K deletion resulted in decreased FcγR-mediated phagocytosis in mouse bone marrow derived macrophages (BMDM) compared to WT controls. To engage FcγR on BMDM, immune complexes (IC) were added comprised of either IgG-opsonized BSA (low avidity) or IgG-opsonized, BSA-coated beads (high avidity). Both types of IC induced Ca2+-dependent phosphorylation of ERK, but this was significantly decreased in Sel K-/- BMDM compared to controls. Nitric oxide (NO) was only induced with high avidity IC and was significantly decreased in Sel K-/- BMDM. PGE2, IL-6, and TNFα were induced by high avidity IC, but not low avidity IC, and were significantly reduced in Sel K-/- BMDM. Phagocytosis of high avidity IC produced lower oxidative burst in Sel K-/- BMDM. Consistent with this reduced oxidative burst, there was reduced destruction of IgG-opsonized West Nile virus in the phagolyzosome of Sel K-/- BMDM compared to controls. Overall, these results suggest that Sel K plays a role in FcγR-mediated signaling and effector functions of macrophages, and high avidity IC are required to induce maximal effects.

Pembedahan adalah terapi paling efektif untuk karsinoma sel basal (KSB). Meskipun sangat jarang bermetastasis, KSB menyebabkan destruksi lokal luas mencakup kerusakan jaringan lunak, kartilago, dan tulang, sehingga memerlukan penanganan lebih komprehensif termasuk rekonstruksi. Tulisan ini melaporkan tata laksana kasus serial karsinoma sel basal di RSUP Dr. M. Djamil Padang periode Januari hingga Mei 2020. Surgical treatment is the most effective treatment in basal cell carcinoma (BCC). Although metastasis is rarely found, basal cell carcinoma causes extensive local destruction including soft tissue, cartilage, and bone damage requiring more comprehensive treatment including reconstruction. A series of basal cell carcinoma cases management in Dr. M. Djamil General Hospital Padang during January to May 2020 was reported.

<p>Pembedahan adalah terapi paling efektif untuk karsinoma sel basal (KSB). Meskipun sangat jarang bermetastasis, KSB menyebabkan destruksi<br />lokal luas mencakup kerusakan jaringan lunak, kartilago, dan tulang, sehingga memerlukan penanganan lebih komprehensif termasuk<br />rekonstruksi. Tulisan ini melaporkan tata laksana kasus serial karsinoma sel basal di RSUP Dr. M. Djamil Padang periode Januari hingga Mei 2020.</p><p>Surgical treatment is the most effective treatment in basal cell carcinoma (BCC). Although metastasis is rarely found, basal cell carcinoma causes<br />extensive local destruction including soft tissue, cartilage, and bone damage requiring more comprehensive treatment including reconstruction.<br />A series of basal cell carcinoma cases management in Dr. M. Djamil General Hospital Padang during January to May 2020 was reported.</p>

Latar belakang: Kolesteatoma adalah lesi keratin non-neoplastik yang berhubungan dengan proliferasi sel epitel dengan karakteristik morfologi yang menyimpang. Otitis Media Supuratif Kronis (OMSK) yang disertai dengan adanya kolesteatoma dapat mengganggu keseimbangan antara pembentukan tulang dengan resorpsi tulang. Kolesteatoma dapat menghasilkan sitokin-sitokin seperti interleukin-6 (IL-6) yang berperan dalam proses destruksi tulang pendengaran. Tujuan: Mengetahui distribusi derajat kerusakan tulang pendengaran pada pasien OMSK dengan kolesteatoma, rerata kadar IL-6 pada kolesteatoma, dan adanya hubungan antara kadar IL-6 pada kolesteatoma dengan derajat kerusakan tulang pendengaran pada pasien OMSK dengan kolesteatoma. Metode: Penelitian ini melibatkan 6 pasien dengan OMSK dengan kolesteatoma yang dilakukan operasi mastoidektomi. Satu pasien menderita OMSK dengan kolesteatoma bilateral dan dilakukan operasi mastoidektomi pada kedua telinganya. Derajat kerusakan tulang pendengaran dinilai dengan menggunakan kriteria Saleh danMills, sedangkan kadar IL-6 pada kolesteatoma diukur dengan menggunakan instrumen ELISA. Hasil:Derajat kerusakan tulang pendengaran tertinggi yang ditemukan adalah derajat 3 (28,57%), sedangkan derajat kerusakan tulang pendengaran yang terbanyak adalah derajat 2 (42,86%). Kadar IL-6 pada kolesteatoma yang tertinggi adalah 2290 pg/mL, sedangkan rerata kadar IL-6 pada kolesteatoma adalah 1778,57±392,616 pg/mL. Kesimpulan: Kadar IL-6 pada kolesteatoma tidak berhubungan dengan derajat kerusakan tulang pendengaran pada pasien OMSK dengan kolesteatoma (p=0,885).Kata kunci: Kadar IL-6 kolesteatoma, derajat kerusakan tulang pendengaran, OMSK dengan koles-teatoma. ABSTRACTBackgrounds: Cholesteatoma is non neoplastic keratinized lesion related to epithelial cell proliferation with deviated morphologic characteristic. Chronic Suppurative Otitis Media (CSOM) with cholesteatoma may cause imbalance between bone formation and resorption. Cholesteatoma may produce cytokines such as interleukin-6 (IL-6) which has a role in ossicle destruction. Objectives: To evaluate the distribution of ossicle destruction degree in CSOM with cholesteatoma patients, mean of IL-6 level in cholesteatoma and the relationship between IL-6 level in cholesteatoma and ossicle destruction degree in CSOM with cholesteatoma patients. Methods: This study involved 6 CSOM with cholesteatoma patients who underwent mastoidectomy. One patient had bilateral CSOM with cholesteatoma and underwent mastoidectomy in both ears. Ossicle destruction degree was determined by using Saleh and Mills criterias whereas IL-6 level in cholesteatoma was measured by using ELISA kit. Results: The highest ossicle destruction degree was the third degree (28.57%), whereas the most common ossicle destruction degree was the second degree (42.86%). The highest IL-6 level in cholesteatoma was2290 pg/mL, whereas mean of IL-6 level in cholesteatoma was 1778.57 ± 392.616 pg/mL. Conclusions: IL-6 level in cholesteatoma didn’t have relationship with ossicle destruction degree in CSOM with cholesteatoma patients (p=0,885).Keywords: IL-6 level in cholesteatoma, ossicle destruction degree, CSOM with cholesteatoma.

Background: Basal cell carcinoma is one of the most common classifications of non-melanoma skin cancer (75% - 80%) of all cancers. Basal cell carcinoma causes widespread local destruction including soft tissue, cartilage, and bone, thus impairing function and aesthetics, especially for the facial area. One of the most common reconstructive techniques for Basal Cell Carcinoma is the Rhomboid flap. This case report aims to report the use of the rhomboid flap reconstruction technique in post-wide excision of basal cell carcinoma. Case Description: A man, 54 years old, ethnic Balinese, came to the General Surgery Clinic of RSUD Klungkung with a complaint that a mole on the patient's left eye appeared enlarged with itching and bleeds easily. These complaints began to be felt since about 2 weeks before entering the hospital. Initially the patient's mole had been there for 5 years, previously the patient had no complaints about the mole, the initial lesion was in the form of a small brownish lump which was then felt to be getting bigger with itching and bleeding easily. The patient did not complain of pain. Examination of the localized status on the lateral periorbital sinistra showed blackish nodules with hyperpigmented macules, solitary, 2cm x 1cm in size, visible erosions, well-defined borders, irregular shape. Conclusion: The provisional diagnosis of Suspected Malignant Skin Tumor was established based on history, physical examination, with management therapy wide excision and reconstruction with Rhomboid Flap followed with biopsy. Latar Belakang : Karsinoma Sel Basal (KSB) adalah salah satu kanker kulit yang paling sering ditemukan dari seluruh kanker kulit non melanoma. Karsinoma Sel Basal dapat mengakibatkan kerusakan local dengan infiltrasi yang luas sehingga mengganggu fungsi dan estetika, terutama untuk daerah wajah. Salah satu pilihan teknik rekonstruksi yang bisa dilakukan pada Karsinoma Sel Basal di regio wajah adalah Rhomboid flap. Laporan kasus ini bertujuan untuk melaporkan penggunaan tehnik rekonstruksi dengan flap rhomboid pada pasca eksisi luas pada karsinoma sel basal. Deskripsi Kasus: Seorang laki-laki, 54 tahun, suku Bali, datang ke Poliklinik bedah Umum RSUD Klungkung dengan keluhan tahi lalat pada sebelah mata kiri pasien tampak membesar disertai gatal dan mudah berdarah. Keluhan tersebut mulai dirasakan sejak sekitar 2 minggu sebelum masuk RS. Awalnya tahi lalat pasien sudah ada sejak 5 tahun yang lalu, sebelumnya pasien tidak ada keluhan pada tahi lalat tesebut, lesi awal berupa benjolan kecil berwarna kecoklatan yang kemudian makin lama dirasakan makin membesar disertai rasa gatal dan mudah berdarah. Keluhan nyeri tidak dikeluhkan oleh pasien. Pemeriksaan status lokalis pada periorbital lateral S tampak nodul kehitaman disertai makula hiperpigmentasi, soliter, ukuran 2cm x 1cm, tampak erosi, batas tegas, bentuk tidak beraturan. Kesimpulan: Diagnosis sementara Tumor Kulit Suspek Malignant ditegakkan berdasarkan anamnesis, pemeriksaan fisik dengan terapi eksisi luas + biopsi + rekonstruksi dengan Rhomboid Flap.

Riset ini memiliki tujuan untuk menghitung efisiensi kinerja chlorination plant saat sebelum serta setelah transformasi dimodifikasi, serta membagikan saran terpaut pembedahan yang pas supaya bebas dari kehancuran. Kelayakan riset yang penulis gunakan adalah kualitatif dengan menggunakan metode deskriptif. Informasi dikumpulkan dengan mengamati parameter pembedahan chlorination plant serta observasi dan Analisa buku petunjuk. Hasil penelitian menunjukkan bahwa konsentrasi kaporit yang dihasilkan menurun setelah cell 4 mengalami kerusakan. Modus operasi dengan 3 sel masih layak dan pengoperasian terbilang aman.The aim of this research is to calculate the efficiency of chlorination plant performance before and after the modified transformation, and to provide appropriate surgical advice so that it is free from destruction. The feasibility of the research that the author uses is qualitative using descriptive methods. Information was collected by observing the surgical parameters of the chlorination plant as well as observation and analysis of the manual. The results showed that the concentration of chlorine produced decreased after cell 4 was damaged. The operating mode with 3 cells is still feasible and the operation is fairly safe.

Background: Survival of laryngeal cancer cases depend on lymph nodes involvement. Tissue inhibitormetaloproteinase-2 (TIMP-2) has double effects on matrix metalloproteinase. TIMP-2 could inhibit orinduce metastasis process. Its expression depends on tumor location and histopathology. Purpose: Tofind out the presence of TIMP-2 on biopsy specimens of laryngeal squamous cell carcinoma and itsrelation to lymph node involvement. Methods: The immunoexpression of TIMP-2 was studied on biopsy specimens of 15 laryngeal carcinomas with lymph node metastasis and 18 patients without, collected between 2005-2009. Immunohistochemistry test were carried out in Pathology Department Universityof Indonesia using TIMP-2 (3A4) sc 21735 antibody from Santa Cruz. We used analytic-descriptivestudy to compare TIMP-2 expression between laryngeal squamous cell carcinoma with lymph node metastasis and those without. Results: The median of TIMP-2 immunoexpression in laryngeal squamouscell carcinoma in patients with lymph node involvement was 99 and the median in patients withoutlymph node metastases was 97, with range between 0-100. Statistical analysis revealed no significantdifference in TIMP-2 expression between groups with metastasis and without (p=0.403). Conclusions:Our results could not differentiate the TIMP-2 expression from patients with laryngeal squamous cellcarcinoma with lymph node metastasis and without. However, imbalances in the extracellular activitiesof matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases, linked to pathologicaltissue destruction, are more complex and need further investigation. Further study on correlationbetween TIMP-2 and MMP2-MT-1MMP immunoexpression is advised to determine its relationship tolymph node metastasis and to plan more aggressive treatment. Keywords: laryngeal squamous cell carcinoma, matrix metalloproteinase, tissue inhibitormetaloproteinase-2 Abstrak : Latar belakang: Angka harapan hidup pasien karsinoma laring ditentukan oleh adanya metastasiskelenjar leher. Tissue inhibitor metaloproteinase-2 (TIMP-2)mempunyai efek ganda pada kerja matriksmetalloproteinase yang merupakan salah satu penanda metastasis. TIMP-2 dapat menghambat ataumenginduksi metastasis. Ekspresi TIMP-2 tergantung pada lokasi dan jenis tumor. Tujuan: Melaporkanekspresi TIMP-2 pada sediaan biopsi karsinoma sel skuamosa laring dan hubungannya dengan metastasiskelenjar limfe leher. Metode: Ekspresi TIMP-2 diteliti pada 15 pasien karsinoma sel skuamosa laringdengan metastasis leher dan 18 pasien tanpa metastasis leher. Pemeriksaan imunohistokimia dilakukanpada jaringan biopsi yang diterima tahun 2005-2009. Imunohistokimia dilakukan sesuai dengan standarpemeriksaan di Departemen Patologi Anatomi FKUI menggunakan antibodi TIMP-2 (3A4) sc 21735 dariSanta Cruz. Penelitian bersifat analitik untuk melihat perbedaan ekspresi TIMP-2 antara karsinoma laringdengan metastasis leher dan yang tanpa metastasis leher. Hasil: Nilai median ekspresi TIMP-2 padakarsinoma laring dengan metastasis leher adalah 99 dan median TIMP-2 pada pasien tanpa metastasisleher adalah 97, dengan kisaran antara 0-100. Analisis statistik memperlihatkan tidak ada perbedaanbermakna pada ekspresi TIMP-2 antara kelompok karsinoma sel skuamosa laring dengan metastasisleher dan yang tanpa metastasis leher (p=0,403). Kesimpulan: Hasil penelitian ini menunjukkan ekspresiTIMP-2 tidak dapat dibedakan antara pasien yang bermetastasis leher dan yang tidak. Keseimbanganaktivitas antara matriks metalloproteinase (MMP) dan tissue inhibitors of matrix metalloproteinase(TIMP) berkaitan dengan destruksi patologis yang kompleks dan membutuhkan penelitian lebih lanjut.Disarankan pemeriksaan korelasi antara ekspresi TIMP-2 dan MMP2 serta dengan MT-1MMP dan_€Ó_x_,_nya dengan metastasis kelenjar limfe leher untuk memprediksikan terapi yang lebih agresif. Kata kunci: karsinoma sel skuamosa laring, matriks metalloproteinase, tissue inhibitor metaloproteinase-2

Anaemia occurs due to several factors, such as deficiency of iron, folic acid, vitamin B12 and protein. Anemia is directly caused by the lack of red blood cell production, the body loses blood either acutely or in a chronic manner, and the destruction of red blood cells is too fast. One of the prevention of anaemia by providing functional food that is developed is tempe which has high quality and nutritional value. The purpose of this study was to examine and analyze the potential of tempeh in increasing hemoglobin levels in patients with anaemia. This research is a literature review with a narrative method that studies and analyzes research results related to the potential of tempe to increase hemoglobin levels in patients with anaemia. The results of this study are the results of a literature review review which shows that Tempe contains an average of 2,0 mg of iron, folic acid 0,9-2,0 mg/kg according to the inoculum used and vitamin B12 raw tempe 0,08 μg/100 grams and cooked tempeh 0,14 μg/100 grams. The conclusion of this study states that tempeh has adequate nutritional value of protein, iron, vitamin B12, and folic acid, so that tempeh has the potential to increase hemoglobin levels in patients with anaemia. Expected, to be the basis of further research on genomics and genetic influences on human against tempe bioavailability as a functional food for adolescent anaemia. Anemia merupakan suatu keadaan jumlah sel darah merah atau kadar hemoglobin (Hb) dalam darah lebih rendah daripada nilai normal. Anemia terjadi karena beberapa faktor, diantaranya defisiensi besi, asam folat, vitamin B12 dan protein. Secara langsung anemia disebabkan kurangnya produksi sel darah merah, tubuh kehilangan darah baik secara akut atau menahun, dan hancurnya sel darah merah yang terlalu cepat. Salah satu pencegahan anemia dengan pemberian bahan pangan fungsional yang dikembangkan yaitu tempe yang mempunyai mutu dan nilai gizi tinggi. Tujuan penelitian adalah untuk mengkaji dan menganalisis potensi tempe dalam meningkatkan kadar hemoglobin pada penderita anemia. Penelitian merupakan literature review dengan metode naratif yang mengkaji dan menganalisis hasil penelitian yang terkait dengan potensi tempe untuk meningkatkan kadar hemoglobin pada penderita anemia. Hasil kajian menunjukkan bahwa Tempe mengandung rata-rata zat besi sebanyak 2,0 mg, asam folat 0,9-2,0 mg/kg sesuai dengan inoculum yang digunakan dan vitamin B12 tempe mentah 0,08 μg/100 gram dan tempe matang 0,14 μg/100 gram. Kesimpulan penelitian ini menyatakan tempe mempunyai nilai gizi zat besi, vitamin B12, dan asam folat yang cukup, sehingga tempe berpotensi untuk meningkatkan kadar hemoglobin pada penderita anemia. Penelitian ini diharapkan menjadi dasar penelitian lanjutan mengenai pengaruh genomik dan genetik pada manusia terhadap bioavabilitas tempe sebagai pangan fungsional untuk remaja anemia.

Abstract—COVID-19 is a major emerging disease that affects any certain condition. However, a recent report suggests the occurrence of hyperglycemia without any present diabetes in COVID-19 patients. This study aimed to systematically review recent evidence on hyperglycemia in COVID-19 patients. Literature research was done using four search engines, consist of Google Scholar, PubMed, ScienceDirect, and ProQuest, and limited to English manuscript only and published from February 2020 to September 2020. SARS-CoV-2 could damage the pancreas by causing the destruction of the β-cell structure that leads to impairment of glucose metabolism and worsen pre-existing diabetes or determine the appearance of hyperglycemia in non-diabetes. Inflammation also plays a major important role in hyperglycemia related to COVID-19. Hyperglycemia increased the vulnerability of the lung, by promoting and facilitating the entry of the SARS-CoV-2 into the host cells, and decreasing lung function. Moreover, the mortality and morbidity rate conceivable increased due to hyperglycemia. The presence of high glucose levels is linked with the progression of COVID-19 severity. Thus, the glucose level should be concerned, either in a patient with present diabetes or without any presence of diabetes. Examination and monitoring of glucose levels might be a useful tool to prevent the seriousness of COVID-19 Keywords: diabetes mellitus, SARS-CoV-2, high glucose level, pulmonary infection Abstrak—COVID-19 adalah penyakit yang muncul yang mempengaruhi kondisi tertentu.Namun, sebuah laporan baru-baru ini menunjukkan terjadinya hiperglikemia tanpa adanya diabetes pada pasien COVID-19. Penelitian ini bertujuan untuk meninjau secara sistematis bukti terbaru tentang hiperglikemia pada pasien COVID-19. Penelitian literatur dilakukan dengan menggunakan empat mesin pencari, yaitu Google Scholar, PubMed, ScienceDirect, dan ProQuest, dan terbatas hanya pada manuskrip berbahasa Inggris dan diterbitkan dari Februari 2020 hingga September 2020. SARS-CoV-2 dapat merusak pankreas dengan menyebabkan kerusakan pada pankreas. struktur sel β yang menyebabkan gangguan metabolisme glukosa dan memperburuk diabetes yang sudah ada sebelumnya atau menentukan munculnya hiperglikemia pada kelompok non-diabetes. Peradangan juga memainkan peran penting utama dalam hiperglikemia terkait COVID-19. Hiperglikemia meningkatkan kerentanan paru-paru, dengan mendorong dan memfasilitasi masuknya SARS-CoV-2 ke dalam sel inang, dan menurunkan fungsi paru-paru. Selain itu, angka mortalitas dan morbiditas yang diperkirakan meningkat karena hiperglikemia. Adanya kadar glukosa yang tinggi dikaitkan dengan perkembangan keparahan COVID-19. Dengan demikian, kadar glukosa harus diperhatikan, baik pada pasien dengan diabetes saat ini atau tanpa adanya diabetes. Pemeriksaan dan pemantauan kadar glukosa mungkin menjadi alat yang berguna untuk mencegah derajat keparahan COVID-19. Kata kunci: diabetes mellitus, SARS-CoV-2, peningkatan kadar glukosa, infeksi paru

The article reflects the issues of construction in the Arctic North. The authors underline the need to use climate information effectively to find the best solutions in preventing the coast and infrastructure destruction due to thawing permafrost and sea level rise. The paper offers the methods for adaptation the structures in the flood zone, for example, the construction methods of the facility: on a displacement base, on piles, inside a dam, on an island.

L'Assoiffé (Pyaasa, 1957), Fleurs de papier (Kaagaz Ke Phool, 1959) et Le Maître, la maîtresse et l'esclave (Sahib Bibi Aur Ghulam, 1962) sont les trois films les plus célèbres, les plus connus et analysés de Guru Dutt. Cette thèse a pour ambition d'élargir le champ des possibles en convoquant sa totalité filmique. Légendaire, mythique, personnel, sincère, autodestructeur, désir de vie et ou de mort… tels sont les qualificatifs qu'on trouve dans la littérature cinématographique pour désigner Guru Dutt et son œuvre. L'intérêt pour l'Inde et son cinéma viennent d'un constat : il y a peu de films indiens distribués en France alors que l'Inde est le premier pays producteur de films au monde. Alors qui est Guru Dutt ? Quelle est sa contribution au cinéma ? Comment a-t-il porté le mélodrame à une dimension épique ? Pourquoi aujourd'hui les jeunes cinéastes qui, à la suite de Satyajit Ray, commencent maintenant à ébranler le système, se référent à lui comme un précurseur, un maître ? Cette thèse entend mettre en lumière les apports cinéphilico-filmiques de cet auteur pour comprendre le cinéma indien par le prisme de son œuvre par une approche socio-historique et phénoménologique nous permettant de retracer l'itinéraire du plus grand cinéaste populaire, musical que l'Inde ait jamais élevé. De sorte que l'œuvre de Guru Dutt, qui a passé avec succès l'épreuve du temps, n'a plus aujourd'hui qu'à franchir l'épreuve de l'espace
Thirsty (Pyaasa, 1957), Paper Flowers (Kaagaz Ke Phool, 1959) and The Master, the Mistress and the Slave (Sahib Bibi Aur Ghulam, 1962) are the three most famous, well-known and analyzed films by Guru Dutt. This thesis aims to broaden the field of possibilities by summoning its filmic totality. Legendary, mythical, personal, sincere, self-destructive, desire for life and or death... these are the qualifiers found in cinematographic literature to designate Guru Dutt and his work. The interest in India and its cinema stems from an observation : there are few Indian films distributed in France, whereas India is the leading film-producing country in the world. Who is Guru Dutt ? What is his contribution to cinema ? How did he take melodrama to an epic dimension ? Why today do the young filmmakers who, following Satyajit Ray, are now beginning to shake up the system, refer to him as a precursor, a master ? This thesis intends to highlight the cinephilico-filmic contributions of this author to understand Indian cinema through the prism of his work through a socio-historical and phenomenological approach allowing us to retrace the itinerary of the greatest popular, musical filmmaker that the India has ever brought up. So that the work of Guru Dutt, which has successfully passed the test of time, now only has to pass the test of space