Dissertations / Theses on the topic 'Segmental approach'
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Reynolds, Jordan Michael. "Hierarchical segment boost : a segment level classification approach to object class recognition." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/32286.
Full textScience, Faculty of
Computer Science, Department of
Graduate
Hosseini-Chaleshtari, Jamshid. "Segment Congruence Analysis: An Information Theoretic Approach." PDXScholar, 1987. https://pdxscholar.library.pdx.edu/open_access_etds/797.
Full textMohd, Norowi Noris. "An artificial intelligence approach to concatenative sound synthesis." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1606.
Full textDjongakodi, Yoto Joseph. "Phonologie segmentale et phonologie syllabique du tetela: une approche paramétrique." Doctoral thesis, Universite Libre de Bruxelles, 1995. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212497.
Full textConyette, Michael H. F. "Determinants of online leisure travel planning decision processes : a segmented approach." Thesis, University of Newcastle Upon Tyne, 2009. http://hdl.handle.net/10443/984.
Full textAiello, Taryn. "An Exploratory Study of Customer Vulnerability: A Cross-Segment Approach." Doctoral diss., University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6232.
Full textPh.D.
Doctorate
Education and Human Performance
Education; Hospitality Education Track
Chang, Jane W. (Jane Wen) 1970. "Near-miss modeling : a segment-based approach to speech recognition." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/46179.
Full textAkesbi, Izeddine. "Vocational training and labour market recruitment in Morocco : towards a segmented approach." Thesis, Institute of Education (University of London), 1991. http://eprints.ioe.ac.uk/18500/.
Full textWiederhold, Philipp. "Segmentberichterstattung und corporate governance Grenzen des Management Approach." Wiesbaden Gabler, 2007. http://d-nb.info/985467975/04.
Full textCaswell, Eric D. "Analysis of a Helix Antenna Using a Moment Method Approach With Curved Basis and Testing Functions." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/37001.
Full textMaster of Science
Salmanpour, Rahmdel Payam. "A parallel windowing approach to the Hough transform for line segment detection." Thesis, Middlesex University, 2013. http://eprints.mdx.ac.uk/12629/.
Full textBaker, Antony Richard. "Approaches to the assessment of combined segment vascular disease." Thesis, University of Leicester, 1986. http://hdl.handle.net/2381/34329.
Full textDurkin, Jennifer Dowling James. "Development of a geometric modelling approach for human body segment inertial parameter estimation /." *McMaster only, 2003.
Find full textBailey, Justin Gray. "Facets, segments, bends and swells: an approach to designing and making in three dimensions." Thesis, University of Iowa, 2016. https://ir.uiowa.edu/etd/3044.
Full textMeddeb, Mimouni Houda. "Contribution à la commande simultanée des systèmes linéaires." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0149/document.
Full textIn this manuscript, a new approach is proposed for the stabilization of polytopes of SISO LTI systems with a fixed order controller. Using the extended segment theorem, we have shown that to stabilize a polytope of LTI systems, it is sufficient to simultaneously stabilize all its vertices by considering an additional condition associated with them. In this paper, we have also presented original methods for the synthesis of simultaneous controllers by combining polynomial techniques and linear optimization. With the proposed synthesis methods, we have shown not only that the controller simultaneously stabilizes the vertices of the system polytope (simultaneous control), but also all systems belonging to the polytope (robust control). It is therefore a simultaneous and robust controller for system polytopes. Before stating results concerning the simultaneous control of all the segments of a polytope of systems, we have studied the control of a segment of systems with an LTI controller. This segment of systems is defined by the two systems located at each of its ends and by a parameter belonging to a given interval. The question of the stabilization of this class of uncertain systems has been formulated as that of a problem of simultaneous control of two systems located at the ends with an equal constraint of the even parts of each of the two characteristic polynomials in closed loop. Conditions of existence of a stabilizing controller for a segment of systems have been given using two polynomial stability criteria : the Hermite-Fujiwara criterion and the Hermite-Biehler criterion. The results obtained for the simultaneous control of a segment of systems have been extended to the stabilization of a polytope of systems. This problem has been reduced to the stabilization of the vertices of the polytope with a simultaneous controller generating closed loop characteristic polynomials having the same even (or odd) part. The existence conditions of these robust, fixed-order and simultaneous controllers are given using the two stability criteria mentioned above. Synthesis algorithms are also developed to design these controllers
Benecke, Birka. "Internationale Rechnungslegung und Management approach : Bilanzierung derivater Finanzinstrumente und Segmentberichterstattung /." Wiesbaden : Wiesbaden : Deutscher Universitäts-Verlag ; Gabler, 2000. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=008939957&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textDhani, Sonja Urmilla. "Experimental approaches for the structural characterization of membrane-spanning segments in proteins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/MQ53330.pdf.
Full textEl, Aynaoui Jean-Philippe Karim. "Pauvreté et marché du travail urbain segmenté au Maroc : une nouvelle approche." Bordeaux 4, 1998. http://www.theses.fr/1998BOR40027.
Full textSegmentation is a specific feature of urban labor markets in developing countries. In this context, numerous empirical evidences are showing the key role of the labor market in explaining poverty. Along these lines, this research strives to explore the relationship between the structure and the functioning of the urban labor market, and poverty in morocco. Indeed, the main purpose is to examine the consequences of occupational vulnerability -we suppose that labor market segmentation is rooted to it- on urban poverty. Following a theoretical review focused on the segmentation concept, a framework with a segmented labor market is presented. Based on differentials in occupational vulnerability, the aim is to detect the allocation process in the segments - individual occupational characteristics are key determinants. Using cross sectional data on urban areas from the 90-91 national living standard measurement survey, the test for the segmentation hypothesis exhibits a non random latent allocation process of the individuals in four segments. Then, in-depth analysis reveals that the incidence of poverty is closely linked to the segmentation dynamic (also to unemployment), suggesting that access to protected jobs is a key determinant of welfare conditions: indeed, 80% of the poor are located in two vulnerable segments. Besides, the results enable to specify earning patterns, and how the urban market function and interact with individual occupational choices and employers decisions. The analysis sheds light on the mechanisms creating vulnerability, and confirms the prevalence of the segmentation hypothesis in urban areas of morocco. The labor market outcomes differs by gender. Due to a better understanding of the asymmetric effects of policies and exogenous shocks on the components of the segmented market, the results contribute to ameliorate the design of policies. Finally, a set of reforms to reduce poverty throughout macroeconomic policy and structural measures is proposed
Dill, Stewart L. "Motivation segments and normative standards, an approach to managing for wilderness experience diversity in Kluane National Park." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0019/MQ37514.pdf.
Full textBender, Guido. "Characterizing spatial conditions within a hydrogen and direct methanol polymer electrolyte fuel cell using the segmented electrode approach." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980321212.
Full textOzdarici, Ok Asli. "A Segment-based Approach To Classify Agricultural Lands Using Multi-temporal Kompsat-2 And Envisat Asar Data." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614195/index.pdf.
Full texthence automated approaches are crucial to maintain sustainability of agricultural activities. The objective of this research is to classify eight crop types cultivated in Karacabey Plain located in the north-west of Turkey using multi-temporal Kompsat-2 and Envisat ASAR satellite data. To fulfill this objective, first, the fused Kompsat-2 images were segmented separately to define homogenous agricultural patches. The segmentation results were evaluated using multiple goodness measures to find the optimum segments. Next, multispectral single-date Kompsat-2 images with the Envisat ASAR data were classified by MLC and SVMs algorithms. To combine the thematic information of the multi-temporal data set, probability maps were generated for each classification result and the accuracies of the thematic maps were then evaluated using segment-based manner. The results indicated that the segment-based approach based on the SVMs method using the multispectral Kompsat-2 and Envisat ASAR data provided the best classification accuracies. The combined thematic maps of June-August and June-July-August provided the highest overall accuracy and kappa value around 92% and 0.90, respectively, which was 4% better than the highest result computed with the MLC method. The produced thematic maps were also evaluated based on field-based manner and the analysis revealed that the classification performances are directly proportional to the size of the agricultural fields.
LAURA, CHANTAL. "Entre segments et regles, une approche perceptive pour la synthese automatique de la parole." Paris 6, 1990. http://www.theses.fr/1990PA066807.
Full textHollmer, Ulrika, and Camilla Haraldsson. "En studie av IFRS 8 – Rörelsesegment i Sverige : Hur påverkades företagen?" Thesis, Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72836.
Full textBackground: IFRS 8 is since 1 January 2009 mandatory for all listed companies in Sweden. It states that companies must implement a management approach, which means that the external reporting of segments should reflect the internal reports. This differs from the previous rules in IAS 14, in which the information should correspond with the other external IFRS accounting principles. Proponents to IFRS 8 argue that the standard gives a better insight into the company which makes it easier for investors and analysts to make decisions and prognosis. Critics argue that IFRS 8 prevents comparisons between companies and force the company to disclose more competitively sensitive information. Aim: Purpose of this study is to examine if the expected benefits of IFRS 8 has been achieved. The study will also examine whether firms is affected by IFRS 8. Completion: The authors used a qualitative data collection consisting of interviews with six companies listed on the OMX Nordic Exchange Stockholm, and the quantitative data collection consists of a survey sent to 233 companies listed on the OMX Nordic Exchange Stockholm as primary data. Secondary data was also gathered through literature studies. Conclusions: The study has revealed that the majority of companies have not implemented a change in the composition of segments and segment information. The majority of the companies did not consider the users to have gained a better insight into the corporate reporting. They argued though that it is important to provide information to its stakeholders. IFRS 8 did not lead to any cost savings for companies.
Postma, Almar School of Chemical Engineering & Industrial Chemistry UNSW. "Approaches to the synthesis of block and graft copolymers with well defined segment lengths." Awarded by:University of New South Wales. School of Chemical Engineering and Industrial Chemistry, 2005. http://handle.unsw.edu.au/1959.4/32822.
Full textMakiese, Ndoma Flavien. "Dynamique du marché du travail congolais en environnement de crise : une approche par l'informalité d'emplois segmentée." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0139.
Full textThis thesis analyses informal employment in the DRC under the assumption of a segmentation. We start with a description of the underlying conditions explaining the emergence, and then spread of informal jobs, which is mainly driven by a structural crisis and the destruction of formal employment in the DRC. The thesis then proposes to reject the uniqueness of the informal sector within the DRC labor market and analyzes its heterogeneity, based on the analyzes of Lautier (2004), Maloney (2004), Fields (2005) and Bacchetta et al. (2009).The thesis therefore highlights the relevance of combining the theories of informality and of segmentation to analyse informal employment in DRC, and applies this framework to two mutually enriching datasets: the 1-2-3 survey, which is quantitative, and qualitative data that we collected in the field and focused on a specific activity: an emerging market for second-hand equipment coming from Europe and called "bilokos" in DRC.The results from these two types of data allow to characterize what we call “the informality of segmented jobs”, a concept that we empirically apply with two levels of analysis: the Characteristics of the informal Activity (C.A.)., and the Profiles of the informal Entrepreneurs (P.E.). Mixed qualitative and quantitative methods allow us to characterize a segmentation in Informal Production Units along four types ranging from lower income to higher income
Wiederhold, Philipp. "Segmentberichterstattung und Corporate Governance : Grenzen des Management Approach /." Wiesbaden : Gabler, 2008. http://www.gbv.de/dms/zbw/543320022.pdf.
Full textNanavati, Hemant. "Molecular modeling of the elastic and photoelastic properties of crosslinked polymer networks: a statistical segment approach / by Hemant Nanavati." Diss., Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/8227.
Full textLavoie, Charles. "Planification inverse avec approche par segments anatomiques et non anatomiques en radiothérapie externe appliquée à l'ORL." Thesis, Université Laval, 2006. http://www.theses.ulaval.ca/2006/23951/23951.pdf.
Full textKachi-Akkouche, Djemaa. "Une approche géométrique pour l'analyse d'une séquence d'images monoculaires." Compiègne, 1996. http://www.theses.fr/1996COMP878S.
Full textMahé, Laurent. "Usure du polytetrafluoroethylène (PTFE) charge : approche par les débits de troisième corps solide : Application aux segments de piston de compresseur." Lyon, INSA, 2000. http://www.theses.fr/2000ISAL0040.
Full textNowadays, the existing wear laws can not predict the contact lifetime when the third body is not a fluid. That the case of contacts between piston rings and cylinder in some air compressors. The main cause comes from the non consideration of the set of parameters which control the flows, therefore wear. The objective of this work is to build the scenario of contact life in term of third body flows and to estimate the contribution of each tribological triplet element on the flows activation. In our case, the tribological triplet is the following: the mechanism (compressor), the first body in contact (rings/cylinder) and the third body. Our approach is composed of the following steps: the state of the art of knowledge on the piston rings from the compressorists point of view, the using of the " conceptual tribological tools " to the studied contacts, the individual study of the triplet elements, the reconstitution of the tribological circuit and the scenario of the contact life in the compressor and then the taking into account the interactions of the triplet elements. This reconstitution is based on dynamic instrumentation of compressor, tests on simulators with in-vivo visualization flows tests, and thermal and mechanical modelings. It leads to the establishment of a phenomenological equation of the third body flows in the contacts rings/cylinder, and the identification of mechanical, materials and physico-chemical parameters which control the t1ows
Schille, Eric. "Propriétés segmentales des longues chaînes polymères dans les réseaux temporaires ou les réticulats générés par le soufre : approche RMN." Université Joseph Fourier (Grenoble), 2004. http://www.theses.fr/2004GRE10162.
Full textViscoelastic properties of long polymeric chains originate essentially from the existence of temporary or permanant networks induced by topological constraints (entaglements or crosslinks). These networks confer a solid-like behavior to the transverse magnetic relaxation of the protons related to the chains. Quantitative NMR approaches developed in this work enable to access to the properties of the statistical segment defined by two consecutive topological constraints. Polybutadiene and polyisoprene are studied. A first part is devoted to study these chains in the melt or in concentrated solutions. We show that NMR is particulary well adapted to the detection of end chain segments generating the reptational movement. The latter appear in dynamic interaction with inner submolecules whose segmental correlation time (arround 1 MS) is also characterized. It presents a molecular weight dependence suggesting a chain dynamic governed by a semi-local friction effect varying as M>0. 4 instead of M>0. In a second part randomly crosslinked chains by sulphur are studied. The properties of these permanent networks are compared with lose of calibrated gels. A uniform NMR behavior is then highlighted as well as NMR parameters directly related to the density of crosslinks through the configurational fluctuations of segments forming the network statistical structures
Gruneau, Joar. "Investigation of deep learning approaches for overhead imagery analysis." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-232208.
Full textAnalys av flyg- och satellitbilder har stor potential att kostnadseffektivt producera data i realtid för beslutsfattande för företag och politik. Varje dag produceras massiva mängder nya satellitbilder. För att fullt kunna utnyttja dessa datamängder krävs ett beräkningseffektivt nätverk för analysen. Denna avhandling föreslår ett nätverk som överträffar Segment Before you Detect-nätverket [6] och olika typer av snabbt regionsbaserade faltningsnätverk [61] med en stor marginal på en bråkdel av tiden. Den föreslagna modellen erhåller ett prediktionsfel för att räkna bilar på 1,67% på Potsdam-datasetet och ökar F1- poängen for fordons detektion på VEDAI-datasetet från 0.305 rapporterat av [61] till 0.542. Denna avhandling visar också att det är möjligt att överträffa Segment Before you Detect-nätverket på mindre än 1% av tiden på bilräkning och fordonsdetektering samtidigt som den föreslagna modellen använder mindre än hälften av upplösningen. Detta gör den föreslagna modellen till en attraktiv lösning för storskalig satellitbildanalys.
Schwinn, Tobias [Verfasser], and Achim [Akademischer Betreuer] Menges. "A systematic approach for developing agent-based architectural design models of segmented shells : towards autonomously learned goal-oriented agent behaviors / Tobias Schwinn ; Betreuer: Achim Menges." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2021. http://d-nb.info/1239116098/34.
Full textKüster, Stephan [Verfasser], Max [Akademischer Betreuer] Göttsche, and Reinald [Akademischer Betreuer] Koch. "The effectiveness of segment disclosures under the management approach: empirical evidence from Europe : summary of the cumulative dissertation / Stephan Küster ; Max Göttsche, Reinald Koch." Eichstätt-Ingolstadt : Katholische Universität Eichstätt-Ingolstadt, 2021. http://d-nb.info/1229991360/34.
Full textMaschke, Bernard. "Contribution à une approche par bond-graph de l'étude et la conception de lois de commande de robots contenant des segments flexibles." Paris 11, 1990. http://www.theses.fr/1990PA112020.
Full textKassar, Nicole [Verfasser], Martin [Akademischer Betreuer] Glöckler, and Martin [Gutachter] Glöckler. "A new approach of three-dimensional guidance in paediatric cath lab: segmented and tessellated heart models for cardiovascular interventions in CHD / Nicole Kassar ; Gutachter: Martin Glöckler ; Betreuer: Martin Glöckler." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1204637717/34.
Full textSueur, Christophe. "Contribution à la modélisation et à l'analyse des systèmes dynamiques par une approche bond-graph : application aux systèmes polyarticulés plans à segments flexibles." Lille 1, 1990. http://www.theses.fr/1990LIL10088.
Full textKromer, Valérie. "Analyse des forces musculaires au cours de la marche : approche en corps rigide et simulation en mécanismes plans flexibles par éléments finis." Vandoeuvre-les-Nancy, INPL, 1993. http://www.theses.fr/1993INPL040N.
Full textSilva, Margarete Virgínia Gonçalves. "A utilização de jogos didáticos em novos segmentos da educação: a prática pedagógica do professor no ensino das ciências no atendimento pedagógico domiciliar." Universidade Tecnológica Federal do Paraná, 2014. http://repositorio.utfpr.edu.br/jspui/handle/1/1064.
Full textThis research is the result of a study conducted with teachers Pedagogical Household Care in Curitiba - PR and conceptions about the use of educational games in teaching and learning of scientific disciplines of science and biology, physics, mathematics and chemistry concepts. Introduces the concepts of Inclusive Education and Special highlighting the concept of Hospital and Home Teaching Service. Also highlights the strategy of using educational games as a contributing factor for the development of cognitive skills and self-esteem seriously compromised because of the student served by this program the Department of Education of the State of Paraná disease. The games were selected on the internet of which had already been tested and results have already registered. The production was handmade. Semi- structured questions were used by a questionnaire and subsequent interviews with the teachers of the DPA for data collection. The methodology used for the data analysis was a case study with qualitative approach. . According to the interviewed teachers, educational games confirmed to be excellent strategy for teaching and learning enriching classes and giving students the opportunity to acquire the knowledge of light and fun way.
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Serrano, Sponton Lucas Ezequiel [Verfasser]. "Effectiveness of ipsi- and contralateral approaches to the ophthalmic segment of the internal carotid artery : a comparative morphometrical characterization in anatomic specimens and 3D- virtual surgical simulations=Effektivität von ipsi- und kontralateralen Zugängen zum ophthalmischen Abschnitt der Arteria carotis interna : eine komparative morphometrische Charakterisierung in anatomischen Präparaten und 3D-virtuelle chirurgische Simulationen / Lucas Ezequiel Serrano Sponton." Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1203321015/34.
Full textJacobs, April Lynn. "Segmental production in bilingual speech a psycholinguistic approach /." 2007. http://www.etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-1828/index.html.
Full textLin, Hsin-Lian, and 林昕璉. "Characterization of ribosomal protein modifications in HeLa cells through a segmental average mass spectrum (saMS)-based approach." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/23ru58.
Full text國立陽明大學
生化暨分子生物研究所
105
Ribosome is a cytoplasmic complex made by ribonucleic acids and proteins that form a factory for protein synthesis in living cells. Besides protein synthesis, ribosomal protein are reported to be involved in cell proliferation, cell differentiation, DNA repair and cell apoptosis. In view of structure-function relationship of ribosome, previous studies show that protein modifications of specific ribosomal proteins are regulated under different conditions. While there are a diverse type of protein modifications present in cells, there were no studies on the overall modification profiles of ribosomal proteins. The lack of such information is probably due to the fact that most methodologies target a specific type of protein modification, rather than universally as many types as possible. In chapter II, in order to investigate how PTMs of ribosomal proteins are involved in ribosomal function, we isolated ribosomal fraction from HeLa cells for their PTM characterization and mass spectrometric analyses helped verifies the adequate purity of these isolated ribosomes. We employed segmental average mass spectrum approach to screen possible modified peptides, and Criterion1 macro and DrawMS2 are applied to verify these candidates. Nearly three hundreds of verified modified peptides from twelve different PTM types are identified. Some of these tandem mass spectra have been annotated, which largely confirms the high confidence of our high-through screening approach. Finally, the high abundances of several types of protein modification indeed implicate their significance in regulation of ribosomal activities. We also discuss how our approach can help identify the protein modifications key to regulation of ribosomal activities.
Palmer, Christopher Jay. "Postures for Precision: An Ecological Approach to Marksmanship and the Issue of Warfighter Load." 2012. https://scholarworks.umass.edu/open_access_dissertations/618.
Full textHasan, Noor Md Sadiqul. "Time dependent flexural analysis of reinforced concrete members." Thesis, 2016. http://hdl.handle.net/2440/103968.
Full textThesis (Ph.D.) (Research by Publication) -- University of Adelaide, School of Civil, Environmental and Mining Engineering, 2016.
Healey, Brian. "Segmented regression : a robust approach /." 2004.
Find full textHuang, Tzu-Hao, and 黃子豪. "Using Proteomic Approaches to Investigate the Pathophysiology of Focal Segmental Glomerulosclerosis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/03040002369220583492.
Full text國防醫學院
醫學科學研究所
99
Focal segmental glomerulosclerosis (FSGS) is a common chronic nephropathy which occurs during both childhood and adulthood. About one-third of FSGS patients finally develop end-stage renal failure within a decade. Since the pathogenesis of FSGS is poorly understood, there is still no best strategy yet for physicians to treat FSGS patients. In addition, because of lack of urinary biomarkers for FSGS, diagnosis and prognosis of this disease still rely mainly on renal biopsy, which is an invasive procedure that can cause damage. The purpose of this study was to screen for proteins which play mechanistical roles in FSGS development and / or serve as biomarkers for FSGS diagnosis and prognosis. This study contains a series of experiments, which can be divided into three parts. First, a 2-DE gel-based proteomic approach was used to identify potential urinary biomarkers of FSGS at the pre-sclerotic stage in an adriamycin-induced FSGS mouse model. Second, biochemical, immunohistochemical, and immunocytochemical methods were used to check the expression of Rab23 and various hedgehog signaling pathway genes at different severity stages of FSGS. Third, the pathophysiological roles of Rab23 were explored by performing proteomics and systems biology analyses on cultured mesangial cells with knockdown or overexpression of Rab23. We successfully established FSGS mouse model by single injection of adriamycin in BALB/c mice. Using this model, we identified a novel protein Rab23 and some urinary protein biomarkers, the elevation of which appears before the development of glomerular sclerosis. Elevations of Rab23, which is one of the identified proteins, can be detected in the urine, but not in the serum, in the FSGS mice. In addition, Rab23 and hedgehog signaling pathway genes were constitutively expressed in normal conditions, and were significantly up-regulated in mesangial cells at the FSGS states. The Knockdown or overexpression of Rab23 not only affected the expression of collagen, but also impacted on expression of a variety of proteins in cultured mesangial cells. Bioinformatics analysis of the identified proteins further revealed the pathophysiological roles of Rab23, including G-protein signal transduction, transcription modulation, RNA stabilization, protein synthesis and degradation, cytoskeleton reorganization, anti-oxidation and detoxification, circadian rhythm regulation and phagocytosis. Taken together, these data indicate that Rab23 could serve as a potential non-invasive biomarker for FSGS development. The proteomics and bioinformatics analyses revealed that Rab23 can impact on multiple biological networks in mesangial cells, and this bionetwork data can give an insight into pathophysiological roles of Rab23 in mesangial cells, and can shed light on the mechanism underlying FSGS.
Deshmukh, Rohan. "Failure recovery in MPLS multicast networks using a segmented backup approach." Thesis, 2004. http://spectrum.library.concordia.ca/8157/1/MQ94694.pdf.
Full textBerka, Reginald Bruce. "Development of a large space robot: A multi-segment approach." Thesis, 1991. http://hdl.handle.net/1911/16419.
Full textHua, Spot Y. S., and 花毓瑄. "Query by Segments: An Approach for Song Retrieval in Music Databases." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/50509142346273394994.
Full text國立清華大學
資訊工程學系
87
In this paper, we present the techniques for retrieving songs by segment. The melody contour is categorized into four types. A segment consists of melody contour of one type and the associated beat (note duration) and pitch (note difference) information. The definitions of similarity for the note duration and the note difference capture the similarity among songs. Moreover, the two-dimensional augmented suffix tree is proposed to speed up the search processing. The minimal and maximal values of data recorded in internal node aid the searching process. Moreover, the threshold propagation function is developed for approximate searching.
Uyen, Nguyen Khoa Tu, and 阮科秀淵. "Using a Fuzzy MCDM Approach for Market Segments Evaluation and Selection." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/42709878194146719364.
Full text南台科技大學
企業管理系
98
Market segments evaluation and selection are critical marketing activities of all companies. This study proposes an effective fuzzy multiple criteria decision-making (MCDM) model for the evaluation and selection of market segments. Market segmentation and market segments evaluation approaches for both consumer markets and business to business markets are first introduced in the literature review. A set of essential criteria for evaluating market segments, including both qualitative and quantitative criteria are selected. The quantitative criteria are further divided into benefit and cost ones. In addition, different importance weights among criteria are considered in the model. The centroid ranking method from Wang et al. (2006) is applied to rank all the final fuzzy evaluation values from the provided model. A numerical example is used to test the model. The proposed model can help companies to evaluate their market segments and select their target market. Finally, some comments are suggested for further research.