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1

Brophy, Alison, Maria Cardinale, Liza B. Andrews, Justin B. Kaplan, Christopher Adams, Yekaterina Opsha, Kimberly A. Brandt, Deepali Dixit, Steven F. Nerenberg, and Julie A. Saleh. "Prospective Observational Evaluation of Sedation and Pain Management Guideline Adherence Across New Jersey Intensive Care Units." Journal of Pharmacy Practice 32, no. 5 (April 23, 2018): 529–33. http://dx.doi.org/10.1177/0897190018770549.

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Background: The practice guidelines for the management of pain, agitation, and delirium (PAD) from the Society of Critical Care Medicine shifted from primarily focusing on the treatment of anxiety in 2002 to the treatment of pain in 2013. Objective: This prospective, observational, multicenter study aimed to assess the degree of practice adherence to the PAD guidelines for ventilated patients in New Jersey intensive care units (ICUs). Methods: Pharmacist investigators at 8 centers designated 4 days at least 10 days apart to evaluate all patients on mechanical ventilation. The primary outcomes included adherence to 4 guideline recommendations: treatment of pain before sedation, use of nonnarcotic analgesic medications, use of nonbenzodiazepine sedative medications, and use of goal-directed sedation. Results: Of 138 patients evaluated, 50% had a primary medical diagnosis (as opposed to surgical, cardiac, or neurological diagnosis), and the median Sequential Organ Failure Assessment (SOFA) score was 7. Pain was treated prior to administration of sedatives in 55.4% of subjects, with fentanyl being the primary analgesic used. In addition, 19% received no analgesia, and 11.5% received nonopioid analgesia. Sedative agents were administered to 87 subjects (48 nonbenzodiazepine and 39 benzodiazepine). Of those receiving benzodiazepines, 22 received intermittent bolus regimens and 16 received continuous infusions, of which 5 were for another indication besides sedation. Validated scales measuring the degree of sedation were completed at least once in 56 (81.6%) patients receiving sedatives. Conclusions: Current sedation practices suggest that integration of evidence-based PAD guidelines across New Jersey adult ICUs is inconsistent despite pharmacist involvement.
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Getter, Lee, and Norman Trieger. "SEDATION—GUIDELINES AND CONTROLS." Journal of the American Dental Association 127, no. 1 (January 1996): 20–22. http://dx.doi.org/10.14219/jada.archive.1996.0011.

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3

Park, Hong Jun, Byung-Wook Kim, Jun Kyu Lee, Yehyun Park, Jin Myung Park, Jun Yong Bae, Seung Young Seo, et al. "2021 Korean Society of Gastrointestinal Endoscopy Clinical Practice Guidelines for Endoscopic Sedation." Clinical Endoscopy 55, no. 2 (March 31, 2022): 167–82. http://dx.doi.org/10.5946/ce.2021.282.

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Sedation can resolve anxiety and fear in patients undergoing endoscopy. The use of sedatives has increased in Korea. Appropriate sedation is a state in which the patient feels subjectively comfortable while maintaining the airway reflex for stable spontaneous breathing. The patient should maintain a state of consciousness to the extent that he or she can cooperate with the needs of the medical staff. Despite its benefits, endoscopic sedation has been associated with cardiopulmonary complications. Cardiopulmonary complications are usually temporary. Most patients recover without sequelae. However, they may progress to serious complications, such as cardiovascular collapse. Therefore, it is essential to screen high-risk patients before sedation and reduce complications by meticulous monitoring. Additionally, physicians should be familiar with the management of emergencies. The first Korean clinical practice guideline for endoscopic sedation was developed based on previous worldwide guidelines for endoscopic sedation using an adaptation process. The guideline consists of nine recommendations based on a critical review of currently available data and expert consensus when the guideline was drafted. These guidelines should provide clinicians, nurses, medical school students, and policy makers with information on how to perform endoscopic sedation with minimal risk.
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Fuchs, Eunice M., and Kathryn Von Rueden. "Sedation Management in the Mechanically Ventilated Critically Ill Patient." AACN Advanced Critical Care 19, no. 4 (October 1, 2008): 421–32. http://dx.doi.org/10.4037/15597768-2008-4008.

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Sedation management in the mechanically ventilated critically ill patient is a topic of continuing interest in the critical care literature. The wide variety of clinical practices described in the literature with regard to sedation management has limited the implementation of evidence-based practice guidelines. Common themes for a coherent sedation management strategy include articulation of indications for sedation, initial and daily evaluation of sedation goals, sedation-level assessment, appropriate sedative selection, effective sedation management strategy, and efficient sedation weaning strategy. We provide a summary of the literature on key aspects of sedation in clinical practice. Evidence-based recommendations are provided for clinicians involved in the management of sedation in mechanically ventilated patients.
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Wong, Irene MJ, Suhitharan Thangavelautham, Sean CH Loh, Shin Yi Ng, Brendan Murfin, and Yahya Shehabi. "Sedation and Delirium in the Intensive Care Unit—A Practice-Based Approach." Annals of the Academy of Medicine, Singapore 49, no. 4 (April 30, 2020): 215–25. http://dx.doi.org/10.47102/annals-acadmed.sg.202013.

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Introduction: Critically ill patients often require sedation for comfort and to facilitate therapeutic interventions. Sedation practice guidelines provide an evidencebased framework with recommendations that can help improve key sedation-related outcomes. Materials and Methods: We conducted a narrative review of current guidelines and recent trials on sedation. Results: From a practice perspective, current guidelines share many limitations including lack of consensus on the definition of light sedation, optimal frequency of sedation assessment, optimal timing for light sedation and consideration of combinations of sedatives. We proposed several strategies to address these limitations and improve outcomes: 1) early light sedation within the first 48 hours with time-weighted monitoring (overall time spent in light sedation in the first 48 hours—sedation intensity—has a dose-dependent relationship with mortality risk, delirium and time to extubation); 2) provision of analgesia with minimal or no sedation where possible; 3) a goal-directed and balanced multimodal approach that combines the benefits of different agents and minimise their side effects; 4) use of dexmedetomidine and atypical antipsychotics as a sedative-sparing strategy to reduce weaning-related agitation, shorten ventilation time and accelerate physical and cognitive rehabilitation; and 5) a bundled approach to sedation that provides a framework to improve relevant clinical outcomes. Conclusion: More effort is required to develop a practical, time-weighted sedation scoring system. Emphasis on a balanced, multimodal appraoch that targets light sedation from the early phase of acute critical illness is important to achieve optimal sedation, lower mortality, shorten time on ventilator and reduce delirium. Ann Acad Med Singapore;49:215–25 Key words: Analgesia, Benzodiazepine, Critical Care, Dexmedetomidine, Propofol
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Penco, Arturo, Francesca Peri, Federico Poropat, Ester Conversano, Egidio Barbi, and Giorgio Cozzi. "Il digiuno del bambino prima di una sedazione procedurale." Medico e Bambino 40, no. 9 (November 15, 2021): 576–82. http://dx.doi.org/10.53126/meb40576.

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Fasting before procedural sedation is a hot topic in everyday medical life with the main concern regarding pulmonary aspiration. Fasting guidelines before procedural sedation have always been the same as those used for general anaesthesia. However, procedural sedation and general anaesthesia differ in terms of invasiveness, drugs, duration and patient characteristics. This results in lower risk of pulmonary aspiration during procedural sedation, when compared to general anaesthesia. Moreover, a large case series of sedations performed in the emergency department with no respect for the proper fasting times showed no association between fasting duration and any type of adverse event with the latter occurring also in patients that properly fasted. The type of procedure (with the need of airway management) and characteristics of the patient seem to matter more. Furthermore, prolonged fasting is uncomfortable and has been associated with hypoglycaemia and dehydration. For this reason, fasting guidelines before procedural sedation should be adapted on the presence of risk factors, such as ASA score, need for airway management, comorbidities, type of procedure and drug used.
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Albizzati, Alessandro, Cristina Riva Crugnola, Margherita Moioli, and Elena Ierardi. "Aspetti positivi e limiti della telemedicina: esperienze di lavoro in Neuropsichiatria infantile in tempo di Covid-19." Medico e Bambino 40, no. 9 (November 15, 2021): 583–86. http://dx.doi.org/10.53126/meb40583.

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Fasting before procedural sedation is a hot topic in everyday medical life with the main concern regarding pulmonary aspiration. Fasting guidelines before procedural sedation have always been the same as those used for general anaesthesia. However, procedural sedation and general anaesthesia differ in terms of invasiveness, drugs, duration and patient characteristics. This results in lower risk of pulmonary aspiration during procedural sedation, when compared to general anaesthesia. Moreover, a large case series of sedations performed in the emergency department with no respect for the proper fasting times showed no association between fasting duration and any type of adverse event with the latter occurring also in patients that properly fasted. The type of procedure (with the need of airway management) and characteristics of the patient seem to matter more. Furthermore, prolonged fasting is uncomfortable and has been associated with hypoglycaemia and dehydration. For this reason, fasting guidelines before procedural sedation should be adapted on the presence of risk factors, such as ASA score, need for airway management, comorbidities, type of procedure and drug used.
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Stevanovic, Predrag. "Midazolam (dormicum®): Clinical practice guidelines." Medical review 59, no. 1-2 (2006): 89–94. http://dx.doi.org/10.2298/mpns0602089s.

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Introduction. Three benzodiazepines are available for IV injection and are commonly used in anesthesia practice: diazepam, lorazepam, and midazolam. The last is the most frequently used in anaesthesia practice. Benzodiazepines induce amnesia and sedation secondary to potentiation of the inhibitory neurotransmitter gamma amino-butyric acid (GABA). Although sleep inducing doses of midazolam (0,2-0,4 mg/kg) may produce unconsciousness in one to three minutes it is commonly used for sedation and to ensure amnesia and premedication. The effects of midazolam on the cardiovascular system are minimal. Mild decreases in blood pressure and heart rate are indicative of its sedative effect. There have been reports of respiratory depression with diazepam, however this response is dose dependent and can be marked if concomitant doses of narcotics are used. Because of its potential for depressing respiration, especially if given with narcotics, the respiratory response of these patients needs to be monitored. Intravenous midazolam should be titrated to effect and the benzodiazepine antagonist flumazenil should be immediately available. .
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Al Maruf, Abdullah, Md Mustafa Kamal, Rafiqul Islam, and Md Saiful Islam. "Paediatric procedural sedation for radiological imaging." Journal of the Bangladesh Society of Anaesthesiologists 24, no. 2 (August 2, 2014): 70–76. http://dx.doi.org/10.3329/jbsa.v24i2.19805.

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Sedation is frequently undertaken for radiological imaging procedures in paediatric patients. Movement during procedure degrades all images of a particular sequence. A deeper level of sedation is needed. The sedation of children is different from the sedation of adult. The safe sedation of children for imaging procedure requires a systematic approach that includes the followings. Careful presedation health evaluation of the child with ASA classification. Appropriate fasting guidelines for sedation procedure. Detailed airway examination for any airway abnormalities that might increase the potential for airway obstruction. Adequate training and skills of sedating personnel in paediatric airway management. Age and size appropriate equipment for airway management and venous access. Adequate medications to combat adverse events. Monitoring of vital parameters during and after the procedure. A properly equipped and staffed recovery area. Recovery to presedation level of consciousness of patient before discharge from medical supervision and appropriate discharge instructions. The whole procedure should be well documented. Children who have contraindications to sedation should be selected for general Anaesthesia. This review article has been made to discuss the need for sedation of children during radiological imaging, currently practiced different regimens of sedation, safe guidelines for sedation and also covers the debate between need for GA versus sedation. DOI: http://dx.doi.org/10.3329/jbsa.v24i2.19805 Journal of Bangladesh Society of Anaesthesiologists 2011; 24(2): 70-76
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MIYAWAKI, Takuya. "Sedation in Dentistry and Guidelines." JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 39, no. 2 (March 15, 2019): 169–77. http://dx.doi.org/10.2199/jjsca.39.169.

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11

Coté, Charles J. "Why we need sedation guidelines." Journal of Pediatrics 138, no. 3 (March 2001): 447–48. http://dx.doi.org/10.1067/mpd.2001.108707.

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12

Devlin, John W., Anne M. Holbrook, and Hugh D. Fuller. "The Effect of ICU Sedation Guidelines and Pharmacist Interventions on Clinical Outcomes and Drug Cost." Annals of Pharmacotherapy 31, no. 6 (June 1997): 689–95. http://dx.doi.org/10.1177/106002809703100604.

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OBJECTIVE: To measure the effect of evidence-based intensive care unit (ICU) sedation guidelines and interventions by a pharmacist to promote these guidelines on the weaning time from mechanical ventilation and sedation drug cost. DESIGN: Before-after study. SETTING: A 15-bed medical-surgical ICU at a tertiary-care teaching hospital. PATIENTS: 100 patients (2 groups of 50 consecutive patients) on mechanical ventilation (assist or pressure control mode for ≥6 h) who were successfully discharged from the ICU. METHODS: ICU sedation guidelines were developed through physician, nursing, and pharmacy consensus using a physician survey and literature overview as points of reference and were implemented into practice. Prospectively, data on the time required to wean patients from mechanical ventilation (successful trial of T-piece, pressure support, or intermittent mandatory ventilation leading to extubation) and total drug costs for sedation were measured and compared between groups. All prospective ICU pharmacist interventions pertaining to sedation were documented. RESULTS: New sedation guidelines promoted lorazepam use in preference to midazolam and suggested propofol for patients not successfully sedated with high-dose lorazepam, haloperidol, or morphine. Over the 2-month collection periods, there was no difference in the median weaning time between the pre- (16 h, range 2–607) and post- (18 h, range 1–284) guideline groups. Total sedation drug costs decreased from $4515 to $1152 ($US) (p = 0.081). Median sedation drug costs decreased from $ 11.27 (range $0–1340) to $3.55 (range $0–250), with the amount (mg) of midazolam and propofol used decreasing by 86% and 100%, respectively. The ICU pharmacist successfully recommended a change from midazolam to lorazepam in 12 of 50 patients, 5 of whom had received midazolam for more than 24 hours. CONCLUSIONS: High compliance with ICU sedation guidelines promoting lorazepam rather than midazolam or propofol in mechanically ventilated patients led to a 75% decrease in sedation drug costs and did not adversely affect the clinicians' ability to wean patients from mechanical ventilation.
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Farina, Nicholas, and Cesar Alaniz. "Reconsidering Dexmedetomidine for Sedation in the Critically Ill: Implications of the SPICE III Trial." Annals of Pharmacotherapy 54, no. 5 (November 19, 2019): 504–8. http://dx.doi.org/10.1177/1060028019890672.

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Dexmedetomidine is a sedative agent that has gained popularity for use in the intensive care unit over the past 20 years. Guidelines recommend dexmedetomidine as a first-line agent to achieve light sedation in mechanically ventilated adults. Recently, the SPICE III (Sedation Practice in Intensive Care Evaluation III) trial was published. This was a randomized controlled trial comparing initial sedation with dexmedetomidine with usual care sedation in adult patients receiving mechanical ventilation. The results of this trial have both validated and contradicted previous findings about dexmedetomidine. This editorial examines the merits of the SPICE III trial and the role of dexmedetomidine in practice following its publication.
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Nissen, Stephen W., and Keith M. Olsen. "Treatment Algorithms in Critical Care: Do They Improve Outcomes?" Journal of Pharmacy Practice 23, no. 1 (February 2010): 61–68. http://dx.doi.org/10.1177/0897190009356555.

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Patients admitted to the intensive care unit (ICU) often have significant underlying morbidities that require complex treatment plans. Because of these complexities, numerous guidelines have been developed to facilitate the management of the critically ill patient. Some of these guidelines include sepsis, community-acquired and ventilator-associated pneumonia, sedation, and glycemic control. Once guidelines are written, a treatment protocol must be developed and implemented within the critical care unit. Our medical center has implemented multiple treatment protocols, often with preprinted order sets with various degrees of success. In 2003, we implemented and later evaluated a sedation order form and protocol. Patients whose sedation was initiated with a standardized order form had more frequent sedation score assessment, less time between sedation vacations, reduced ICU length of ICU stay, and a trend in reduction of ventilator days. However, only 37% of eligible patients were treated using the order form and the protocol, despite the potentially beneficial effects. Some recommendations within guidelines are based on sound clinical evidence supported by randomized controlled trials, although others are based on expert opinion only. The most often-cited reason for protocol noncompliance is disagreement with the published clinical trial data. This paper examines both infectious and noninfectious treatment guidelines and the supportive evidence that they improved patient outcomes. In addition, strategies for successful implementation of a treatment guideline are discussed for clinicians to follow in order to maximize clinical outcomes.
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Trupkovic, Tomislav, Michael Kinn, and Stefan Kleinschmidt. "Analgesia and Sedation in the Intensive Care of Burn Patients." Journal of Intensive Care Medicine 26, no. 6 (January 21, 2011): 397–407. http://dx.doi.org/10.1177/0885066610393442.

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Objective: A variety of agents and techniques are employed in different countries, settings, and medical specialities in order to provide analgesia and sedation in intensive care. Several national guidelines have been published in recent years regarding sedation and analgesia in a general intensive care patient population; however, to date no data exist for patients with burn injuries. The aim of the study was to evaluate analgesia and sedation practice in the intensive care of burn patients in Europe. Design: A postal survey was sent to 188 burn centers in Europe. The addresses were provided by the European Burn Association. The heads of the intensive care units were asked to fill in a structured questionnaire concerning the use of analgesia and sedation in their units. Results: The overall response rate was 27.04%; 63% of European burn centers reported standard operating procedures for sedation and analgesia. A regular score-based assessment of sedation, analgesia, and delirium is carried out by 58%, 60%, and 5%, respectively, of the units. Propofol is the sedative most frequently used for short-term sedation and the weaning phase, whereas benzodiazepines are the preferred substances for medium- and long-term sedation. α2-agonists are widely used during weaning. Opioids are the analgesics of choice for approximately two thirds of the patients. Ketamine is preferred for analgesia in 12% and for sedation in 13% of all substances used. For painful procedures (eg, dressing changes), a large variety of different combinations of analgesics and sedatives are used. Half of the responding intensive care units use neuromuscular blocking agents and supportive nonpharmacological techniques. Two thirds of the European burn centers perceive the need for change in their concepts of analgesia and sedation. Conclusion: A wide variety of drugs are used for analgesia and sedation in European burn centers. This would appear to be due to lack of guidelines or scientific evidence. The implementation of regular assessment of sedation, analgesia, and delirium must be improved. The widespread use of neuromuscular blocking agents should be restricted or even abandoned. Two thirds of the units identify a need for change in their concepts. Valid scientific data are needed to develop guidelines for sedation and analgesia of burn patients.
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Gozal, David, and Keira P. Mason. "Pediatric Sedation: A Global Challenge." International Journal of Pediatrics 2010 (2010): 1–15. http://dx.doi.org/10.1155/2010/701257.

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Pediatric sedation is a challenge which spans all continents and has grown to encompass specialties outside of anesthesia, radiology and emergency medicine. All sedatives are not universally available and local and national regulations often limit the sedation practice to specific agents and those with specific credentials. Some specialties have established certification and credentials for sedation delivery whereas most have not. Some of the relevant sedation guidelines and recommendations of specialty organizations worldwide will be explored. The challenge facing sedation care providers moving forward in the 21st century will be to determine how to apply the local, regional and national guidelines to the individual sedation practices. A greater challenge, perhaps impossible, will be to determine whether the sedation community can come together worldwide to develop standards, guidelines and recommendations for safe sedation practice.
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Slomka, J., L. Hoffman-Hogg, LC Mion, N. Bair, MB Bobek, and AC Arroliga. "Influence of clinicians' values and perceptions on use of clinical practice guidelines for sedation and neuromuscular blockade in patients receiving mechanical ventilation." American Journal of Critical Care 9, no. 6 (November 1, 2000): 412–18. http://dx.doi.org/10.4037/ajcc2000.9.6.412.

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BACKGROUND: Although popular, clinical practice guidelines are not universally accepted by healthcare professionals. OBJECTIVES: To compare nurses' and physicians' actual and perceived rates of adherence to practice guidelines used in sedation of patients receiving mechanical ventilation and to describe nurses' and physicians' perceptions of guideline use. METHODS: Pairs of fellows and nurses caring for 60 eligible patients were asked separately about their rationale for medicating patients, effectiveness of medication, and their perceived adherence to the guidelines. Actual adherence was determined independently by review of medical records. An additional 18 nurses and 11 physicians were interviewed about perceptions of guideline use. RESULTS: Use of mechanical ventilation was the most common reason given by physicians (53%) and nurses (48%) for medicating patients, although reasons for administering medication to a given patient differed in up to 30% of cases. Physicians and nurses disagreed on the effectiveness of medication in 42% (P = .01) of cases. Physicians reported following guidelines in 69% of cases, but their actual adherence rate was only 20%. Clinicians sometimes had difficulty distinguishing among anxiety, pain, and delirium. Clinicians justified variations from guidelines by citing the value of individualized patient care. Nurses and physicians sometimes had different goals in the use of sedation. CONCLUSIONS: Physicians may think they are following sedation guidelines when they are not, and they may prescribe incorrect medications if the cause of agitation is misdiagnosed. Differences between physicians and nurses in values and perceptions may hamper implementation of clinical practice guidelines.
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Payen, Jean-Francois, Gérald Chanques, Jean Mantz, Christiane Hercule, Igor Auriant, Jean-Luc Leguillou, Michèle Binhas, Céline Genty, Carole Rolland, and Jean-Luc Bosson. "Current Practices in Sedation and Analgesia for Mechanically Ventilated Critically Ill Patients." Anesthesiology 106, no. 4 (April 1, 2007): 687–95. http://dx.doi.org/10.1097/01.anes.0000264747.09017.da.

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Background The authors conducted a patient-based survey of practices to fully describe the assessment and the management of pain and sedation of a large cohort of mechanically ventilated patients during their first week of intensive care unit (ICU) stay. Methods A total of 1,381 adult patients were included in a prospective, observational study in 44 ICUs in France. Pain and sedation assessment, analgesic and sedative use, and analgesic management during procedural pain were collected on days 2, 4, and 6 of the ICU stay. Results The observed rates of assessment on day 2 for sedation (43%) and analgesia (42%) were significantly smaller than that of use of sedatives (72%) and opioids (90%), also noted on days 4 and 6. The use of protocols/guidelines for sedation/analgesia in the ICU reduced the proportion of patients who were treated, although not evaluated. A large proportion of assessed patients were in a deep state of sedation (40-50%). Minor changes in the dosages of the main prescribed agents for sedation (midazolam, propofol) and analgesia (sufentanil, fentanyl, morphine, remifentanil) were found across 6 days of the patient's ICU stay. Procedural pain was specifically managed for less than 25% of patients; during those procedures, the proportion of patients with pain significantly increased from the baseline pain evaluation. Conclusions Excessively deep states of sedation and a lack of analgesia during painful procedures must be prevented. To facilitate systematic pain and sedation assessment and to adjust daily drug dosages accordingly, it seems crucial to promote educational programs and elaboration of protocols/guidelines in the ICU.
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Bekkevold, Marit, Reidar Kvåle, and Guttorm Brattebø. "Relation of Reported Sedation and Ventilator Weaning Practices to Ventilator Time in Norwegian Intensive Care Units." Journal of Critical Care Medicine 2015 (May 26, 2015): 1–8. http://dx.doi.org/10.1155/2015/173985.

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Background. Guidelines for sedation, ventilator weaning, and delirium screening are helpful to avoid too deep sedation and to identify signs of delirium in the intensive care unit (ICU). Methods. National ICU registry members (n=37) were surveyed regarding use of scoring instruments and guidelines for sedation and ventilator weaning, choice of drugs, and daily sedation interruption practices. Results were merged with registry data on ventilator time and length of stay for ICU patients ventilated >24 hours (7.075 ICU stays). Results. Eighty-five percent of the 33 responding ICUs used sedation scales and 39% and 55% had sedation and weaning protocols, respectively. An association was found between using protocols and longer mean ventilator time and mean length of ICU stay. Thirty three percent (11/33) practiced daily sedation interruption. Regular delirium assessment was associated with significantly shorter mean ventilator time and mean length of ICU stay but used by few. Conclusion. More ICUs had guidelines for weaning than for sedation. The ventilator time and length of ICU stay compared well with other studies. Although having guidelines was associated with longer ventilator time and ICU stay, the differences were rather small. Daily sedation interruption was seldom used. Few units used delirium scoring instruments.
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Obara, Katsutoshi, Ken Haruma, Atsushi Irisawa, Mitsuru Kaise, Takuji Gotoda, Masanori Sugiyama, Satoshi Tanabe, et al. "Guidelines for sedation in gastroenterological endoscopy." Digestive Endoscopy 27, no. 4 (April 14, 2015): 435–49. http://dx.doi.org/10.1111/den.12464.

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Murthy, TVSP. "Sedation Guidelines for Gastro Intestinal Endoscopy." Medical Journal Armed Forces India 65, no. 2 (April 2009): 161–65. http://dx.doi.org/10.1016/s0377-1237(09)80133-0.

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Goodchild, Jason H., and Mark Donaldson. "New sedation and general anesthesia guidelines." Journal of the American Dental Association 148, no. 3 (March 2017): 138–42. http://dx.doi.org/10.1016/j.adaj.2016.12.030.

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McKernon, Sarah. "Update on the new sedation guidelines." Dental Nursing 11, no. 12 (December 2, 2015): 739–40. http://dx.doi.org/10.12968/denn.2015.11.12.739.

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Coté, Charles J. "American Academy of Pediatrics Sedation Guidelines." Archives of Pediatrics & Adolescent Medicine 166, no. 11 (November 1, 2012): 1067. http://dx.doi.org/10.1001/archpediatrics.2012.1355.

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Schneeweiss, Suzan, and Savithiri Ratnapalan. "Impact of a multifaceted pediatric sedation course: self-directed learning versus a formal continuing medical education course to improve knowledge of sedation guidelines." CJEM 9, no. 02 (March 2007): 93–100. http://dx.doi.org/10.1017/s1481803500014858.

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ABSTRACTBackground:Procedural sedation guidelines were established for a tertiary care pediatric emergency department (ED). We developed a pediatric procedural sedation course to disseminate these guidelines.Objective:Our objective was to evaluate the effectiveness of a sedation course in improving physicians' knowledge of pediatric procedural sedation practices and guidelines, relative to individual self-directed learning.Methods:We recruited emergency staff physicians and fellows as well as fourth-year pediatric residents in a tertiary care pediatric ED to participate in a randomized, controlled, educational intervention. All consenting physicians received pediatric sedation educational material for individual study 2 weeks before a learning assessment. Participants were randomly assigned to one of 2 groups. The self-directed learning group (n= 24) completed a multiple-choice examination without receiving any formal teaching. The study group (n= 24) participated in a 4-hour formal multi-faceted sedation course before writing the multiple-choice examination.Results:The groups did not differ significantly in demographic characteristics or self-perceived knowledge of pediatric sedation. The formal teaching group's median examination score (83.3%; range 75.8%–96.5%) was significantly higher (p< 0.0001) than the median examination score of participants in the self-directed study group (73.3%, range 43.5%–86.6%).Conclusion:The multifaceted sedation course was more effective in improving physician knowledge and understanding of sedation guidelines and practices than unstructured, self-directed learning.
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Robijn, Lenzo, Luc Deliens, Anne-Lore Scherrens, Nele S. Pauwels, Peter Pype, Judith Rietjens, and Kenneth Chambaere. "A systematic review of quality improvement initiatives for continuous sedation until death." Palliative Medicine 35, no. 4 (March 15, 2021): 670–82. http://dx.doi.org/10.1177/0269216321996990.

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Background: Extensive debate surrounds the practice of continuous sedation until death within end-of-life care. Aim: To provide insight into existing initiatives to support the practice of continuous sedation until death and assess their feasibility and effectiveness. Design: Systematic review and narrative synthesis, registered on PROSPERO (CRD42020149630). Data sources: Records were searched through MEDLINE, EMBASE, CENTRAL, CINAHL, and Web of Science from inception to April 16 2020. Peer-reviewed studies reporting original data on initiatives to support the practice of continuous sedation were included for review. Results: Twenty-one studies met the criteria and were included. Initiatives were focused on assessment tools of consciousness and discomfort (9), the use of guidelines and protocols (8), and expert consultation (3). All initiatives were reported as useful, acceptable, and feasible. Studies on the use of monitoring devices showed that a small proportion of patients were found to be awake, despite the patient being unresponsive according to the observer-based sedation scales. However, the wide range of values of these monitoring devices for comfortable and adequately sedated patients seems to hamper its overall implementation in daily clinical practice. Physicians reported changes in practice conform to guideline recommendations but the shift was modest at best. Expert consultation was regarded as supportive when sufficient expertise is lacking and helpful in avoiding possibly unnecessary sedations. Conclusions: The reviewed initiatives may contribute to improvement of continuous sedation until death, though their evidence base is rather limited. More insight is needed into their feasibility, preconditions for effective implementation and impact in actual practice.
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Kim, Na Yeon, Hyeon Ok Ju, and So Yeon Park. "Performance and Knowledge of Nurses on the Practice of Pediatric Sedation." Journal of The Korean Society of Maternal and Child Health 25, no. 4 (October 31, 2021): 260–68. http://dx.doi.org/10.21896/jksmch.2021.25.4.260.

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Purpose: This study aimed to examine the pediatric sedation knowledge and performance of nurses in tertiary hospitals.Methods: Altogether 120 nurses working in the Pediatric Departments of 4 tertiary hospitals in Busan and Kyungnam participated in this descriptive survey. The questionnaire was developed based on domestic and international guidelines and consisted of 40 questions including 18 questions on knowledge and 22 on the performance level of sedation nursing.Results: The mean score regarding the knowledge of pediatric sedation care was 3.14 points and the mean performance level score was 3.44 points. Questions that received low scores in terms of pediatric sedation care knowledge included items regarding the latest policies, level of sedation, and fasting before sedation. Questions that received low scores in the performance level included items regarding psychological preparation before sedation, sedation education considering developmental level and disease, and items related to blood pressure measurement. Pediatric sedation knowledge scores were higher in the groups with higher age, longer clinical experience, higher educational experience, and awareness of sedation guidelines. Performance scores were significantly higher in the groups having educational experience in pediatric sedation and in those exhibiting awareness of sedation guidelines.Conclusion: Sedation education was significantly associated with both knowledge and performance of sedation nursing, conducting educational programs on pediatric sedation nursing.
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Kim, Hyuntae, Ji-Soo Song, Hong-Keun Hyun, Young-Jae Kim, Jung-Wook Kim, Ki-Taeg Jang, Sang-Hoon Lee, and Teo Jeon Shin. "Characteristics of Intravenous Midazolam Sedation with Nitrous Oxide in Pediatric Dental Treatment." JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY 47, no. 1 (February 29, 2020): 53–61. http://dx.doi.org/10.5933/jkapd.2020.47.1.53.

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Midazolam is a short-acting benzodiazepine that is widely used in pediatric dental sedation. However, its clinical effectiveness as an intravenous sedative agent in children has not been widely documented. A retrospective study was conducted to evaluate the efficacy and safety of intravenous midazolam and nitrous oxide inhalation sedation in pediatric dental treatment.<br/>The subjects were 115 patients (118 cases) who received dental treatment under intravenous midazolam and nitrous oxide inhalation sedation. Demographic factors, general health status, sedation time, midazolam and nitrous oxide dosage, and success rate of sedation were evaluated from electronic medical records.<br/>Behavioral management was the main reason of choosing sedation. Mean duration of sedation was 56.7 minutes for surgical treatment, and 74.4 minutes for restorative treatment. The initial dosage of intravenous midazolam was 0.051 ± 0.019 mg/kg. In 34 cases (28.8%), additional midazolam of 0.036 ± 0.057 mg/kg was delivered during the treatment. The concentration of nitrous oxide was maintained between 40% and 50%. The success rate of sedation was 99% (n = 117). In 1 case, laryngospasm occurred and the patient was reversed with benzodiazepine antagonist, flumazenil.<br/>Intravenous midazolam sedation with nitrous oxide was shown to be clinically effective for the dental treatment in children, if administered by trained personnel and patients are carefully selected in accordance with guidelines.
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Anand, Prabhleen Singh, and Leah Rachel Adams. "Using inhalation sedation in practice." Dental Update 49, no. 2 (February 2, 2022): 166–71. http://dx.doi.org/10.12968/denu.2022.49.2.166.

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This article outlines considerations for use of inhalation sedation (IS) in a primary care setting. It looks at indications, contra-indications and case selection for use of IS in practice. The article also considers relevant rules, regulations and guidelines a practitioner should be aware of if practicing inhalation sedation. Some useful practical tips are included on setting up an inhalation sedation practice and being compliant with the Care Quality Commission (CQC) regulations. Standard requirements for staff and patient safety in practice setting are discussed, as are training, governance and CPD requirements for the dental team providing sedation in accordance with latest guidelines on conscious sedation. CPD/Clinical Relevance: This article will be useful for clinicians looking to update their knowledge on the use of inhalation sedation in the primary care setting.
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30

Williams, Katherine. "Guidelines in Practice: Moderate Sedation and Analgesia." AORN Journal 115, no. 6 (May 26, 2022): 553–64. http://dx.doi.org/10.1002/aorn.13690.

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31

Poh, Ya Nee, Pei Fen Poh, Siti Nur Hanim Buang, and Jan Hau Lee. "Sedation Guidelines, Protocols, and Algorithms in PICUs." Pediatric Critical Care Medicine 15, no. 9 (November 2014): 885–92. http://dx.doi.org/10.1097/pcc.0000000000000255.

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32

Feinstein, Kate A. "Conscious Sedation Guidelines and Standards: Safer Sleep." Seminars in Interventional Radiology 18, no. 04 (2001): 399–404. http://dx.doi.org/10.1055/s-2001-19101.

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33

Green, Steven M., and Donald M. Yealy. "Procedural Sedation Goes Utstein: The Quebec Guidelines." Annals of Emergency Medicine 53, no. 4 (April 2009): 436–38. http://dx.doi.org/10.1016/j.annemergmed.2008.10.029.

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34

Ang, Tiing Leong, Edwin Seet, Yaw Chong Goh, Wee Khoon Ng, Calvin Jianyi Koh, Hock Foong Lui, James Weiquan Li, et al. "Academy of Medicine, Singapore clinical guideline on the use of sedation by non-anaesthesiologists during gastrointestinal endoscopy in the hospital setting." Annals of the Academy of Medicine, Singapore 51, no. 1 (January 25, 2022): 24–39. http://dx.doi.org/10.47102/annals-acadmedsg.2021306.

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Introduction: In Singapore, non-anaesthesiologists generally administer sedation during gastrointestinal endoscopy. The drugs used for sedation in hospital endoscopy centres now include propofol in addition to benzodiazepines and opiates. The requirements for peri-procedural monitoring and discharge protocols have also evolved. There is a need to develop an evidence-based clinical guideline on the safe and effective use of sedation by non-anaesthesiologists during gastrointestinal endoscopy in the hospital setting. Methods: The Academy of Medicine, Singapore appointed an expert workgroup comprising 18 gastroenterologists, general surgeons and anaesthesiologists to develop guidelines on the use of sedation during gastrointestinal endoscopy. The workgroup formulated clinical questions related to different aspects of endoscopic sedation, conducted a relevant literature search, adopted Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology and developed recommendations by consensus using a modified Delphi process. Results: The workgroup made 16 recommendations encompassing 7 areas: (1) purpose of sedation, benefits and disadvantages of sedation during gastrointestinal endoscopy; (2) pre-procedural assessment, preparation and consent taking for sedation; (3) Efficacy and safety of drugs used in sedation; (4) the role of anaesthesiologist-administered sedation during gastrointestinal endoscopy; (5) performance of sedation; (6) post-sedation care and discharge after sedation; and (7) training in sedation for gastrointestinal endoscopy for non-anaesthesiologists. Conclusion: These recommendations serve to guide clinical practice during sedation for gastrointestinal endoscopy by non-anaesthesiologists in the hospital setting. Keywords: Benzodiazepines, gastrointestinal endoscopy opiates, propofol, sedation
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Kennedy, Michele, Dana Bullick, Sharon Barniak, Joanne McGovern, Trisha Patel, and Jeffrey Hoag. "Reducing pain, agitation and delirium to optimize outcomes in mechanically ventilated critically ill oncology patients." Journal of Clinical Oncology 34, no. 7_suppl (March 1, 2016): 233. http://dx.doi.org/10.1200/jco.2016.34.7_suppl.233.

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233 Background: Greater than 60% of cancer patients experience chronic pain which is heightened in critical illness. Optimal pain assessment is challenging in the critically ill leading to under treatment due to sedation during mechanical ventilation (MV). The Society of Critical Care Medicine (SCCM) favors treating pain with intermittent boluses rather than continuous infusions; however,appropriate analgesic doses and means of titration are elusive leading to over sedation, prolonged ventilation, and delirium. Utilization of protocols promotes better nursing assessment of sedation-delirium scores which reduce the use of sedatives. The purpose of this study was to assess the need for a nurse driven pain-sedation protocol in ventilated oncology patients. Methods: This retrospective study included 51 mechanically ventilated oncology patients admitted between12/2013 and 6/2015. The analgesics, sedatives, dosing and duration of MV were collected. Sedative titration was evaluated relative to analgesics used by nursing staff. Results: Fentanyl was administered in 94% of patients, an average rate of 142mcg/hr (3413mcg/day) significantly higher than rates of 43mcg/hr). Midazolam was administered at an average rate of 1.25mg/hr in 57%, while 54% received propofol (15.5mcg/hr), demonstrating concurrent use of sedatives and analgesics. In 49%, sedatives were increased without prior adjustment of analgesics indicating that pain was unaddressed and undertreated. In the setting of over-sedation nursing neurological assessment was difficult and associated with prolonged duration of MV (9.7 days). Conclusions: Guidelines recommend “analgesia-first sedation” to promote use of analgesic agents over sedatives to treat pain and agitation and reduce undertreating pain. This becomes crucial in the oncology population. This study demonstrates inconsistencies with guidelines and further supports the need for a structured pain-sedation protocol to decrease over-sedation, adequately treat pain and potentially decrease delirium and prolonged MV. Subsequently, a protocol has been developed which will be implemented after education has been provided to the multidisciplinary team.
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Nystrøm, Vivian, Brita Fosser Olsen, and Idunn Brekke. "Practised sedation in mechanically ventilated patients: A survey of nurses’ perceptions." Nordic Journal of Nursing Research 40, no. 2 (February 17, 2020): 105–12. http://dx.doi.org/10.1177/2057158519899548.

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Recent clinical practice guidelines recommend analgosedation in intensive care unit patients, where the patients' pain first is relieved, followed by sedatives only on indication. The aims of the present study was to examine sedation practice today, to evaluate the degree to which there is a difference in sedation practice between units, and to investigate the associations between nurses' demographic characteristics and their perception of sedation practice. A cross sectional survey was conducted to the nurses in three intensive care units in Norway. The results indicated that light sedation was implemented in the three intensive care unit studied. Continuous infusion of propofol and dexmedetomidine were used most frequently, and continuous infusion of midazolam was used occasionally. However, the sedation practices varied significantly between the units. Subjective scoring systems, physician's prescriptions, and prescription follow-up were reported to be most frequently used as guidelines and directives, and Richmond Agitation–Sedation Scale was reported to be the most frequently used sedation assessment tool.
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37

Shah, Apurva, Shravan Bohra, and Megha Shah. "Sedation and Anesthesia in Gastrointestinal Endoscopy: Indian Scenario." Journal of Digestive Endoscopy 10, no. 02 (April 2019): 097–100. http://dx.doi.org/10.1055/s-0039-1693538.

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AbstractSedation in endoscopy is a drug-induced depression in the level of consciousness. Traditionally, the sedation regime most commonly used for conscious sedation during gastrointestinal (GI) endoscopy was a combination of opioids and benzodiazepines. However, in the last two decades, propofol is regarded as the sine qua non agent for gastroenterological endoscopic sedation. A thorough risk evaluation before the procedure and monitoring during the procedure are paramount. In elective endoscopy, unplanned adverse events are rare, occurring in 1.4% of procedures. All currently available guidelines state that the endoscopist is not permitted to administer propofol and to monitor the patient. This task must be done by an additional person, who has the sole responsibility of administering the sedative and monitoring the patient. Various scoring systems exist for defining the discharge criteria, of which the Aldrete score is the most commonly used.
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38

Evans, Abbie, and Kenneth Nugent. "Iatrogenic opioid withdrawal syndrome presentation and considerations." Southwest Respiratory and Critical Care Chronicles 10, no. 45 (October 21, 2022): 37–41. http://dx.doi.org/10.12746/swrccc.v10i45.1093.

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The 2018 Critical Care Medicine Guidelines for Analgesia and Sedation in the ICU Good Practice Statement emphasized the importance in the treatment of pain taking precedence over sedation. Within these guidelines, a multimodal analgesia approach is standard of care in the ICU, which often includes the initiation of opioids. 1 As practice has shifted to prioritize pain management over sedation, opioids have been administered in frequent and prolonged dosages, making the critically ill patient susceptible to iatrogenic opioid withdrawal syndrome (IOWS). This article provides an overview of IOWS to alert clinicians to the diagnosis of IOWS in ICU patients.
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39

Seo, Yijun, Hak-Jae Lee, Eun Jin Ha, and Tae Sun Ha. "2021 KSCCM clinical practice guidelines for pain, agitation, delirium, immobility, and sleep disturbance in the intensive care unit." Acute and Critical Care 37, no. 1 (February 28, 2022): 1–25. http://dx.doi.org/10.4266/acc.2022.00094.

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Background: To revise and expand the “2010 Guideline for the Use of Sedatives and Analgesics in the Adult Intensive Care Unit (ICU).”Methods: We revised the 2010 Guideline based mainly on the 2018 “Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption (PADIS) in Adult Patients in the ICU,” which was an updated 2013 pain, agitation, and delirium guideline with the inclusion of two additional topics (rehabilitation/mobility and sleep). Since it was not possible to hold face-to-face meetings of panels due to the coronavirus disease 2019 (COVID-19) pandemic, all discussions took place via virtual conference platforms and e-mail with the participation of all panelists. All authors drafted the recommendations, and all panelists discussed and revised the recommendations several times. The quality of evidence for each recommendation was classified as high (level A), moderate (level B), or low/very low (level C), and all panelists voted on the quality level of each recommendation. The participating panelists had no conflicts of interest on related topics. The development of this guideline was independent of any industry funding.Results: The Pain, Agitation/Sedation, Delirium, Immobility (rehabilitation/mobilization), and Sleep Disturbance panels issued 42 recommendations (level A, 6; level B, 18; and level C, 18). Conclusions: The 2021 clinical practice guideline provides up-to-date information on how to prevent and manage pain, agitation/sedation, delirium, immobility, and sleep disturbance in adult ICU patients. We believe that these guidelines can provide an integrated method for clinicians to manage PADIS in adult ICU patients.
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Pisani, Margaret A., John W. Devlin, and Yoanna Skrobik. "Pain and Delirium in Critical Illness: An Exploration of Key 2018 SCCM PADIS Guideline Evidence Gaps." Seminars in Respiratory and Critical Care Medicine 40, no. 05 (October 2019): 604–13. http://dx.doi.org/10.1055/s-0039-1698809.

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AbstractManaging pain and delirium are crucial to patients, families, and caregivers in intensive care units. The Society of Critical Care Medicine 2018 Pain, Agitation/Sedation, Delirium, Immobility, and Sleep disruption (PADIS) guidelines reviewed literature until October 2015 and made its recommendations for critically-ill adults. This chapter addresses evidence gaps, identified during the guideline process, most relevant to clinicians, adds newer evidence published after the PADIS 2018 guidelines were produced, describes hindsight-driven PADIS process or content-related gaps, and reflects on how these considerations may help inform future research investigations and new guideline efforts.
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41

Malis, David J., and Deborah M. Burton. "Safe Pediatric Outpatient Sedation: The Chloral Hydrate Debate Revisited." Otolaryngology–Head and Neck Surgery 116, no. 1 (January 1997): 53–57. http://dx.doi.org/10.1016/s0194-59989770352-8.

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Diagnostic imaging in the pediatric patient frequently requires sedation. The use of chloral hydrate, the standard agent for many years, has recently come under severe scrutiny. The American Academy of Pediatrics (AAP) published guidelines for the elective sedation of pediatric patients; however, compliance with the AAP guidelines is not compulsory. A review of the medical literature shows a wide range of medications used for pediatric sedation, along with a diversity in the protocols available for monitoring the cardiopulmonary status of the patient. When ordering computed tomography and magnetic resonance imaging scans, pediatric otolaryngologists indirectly are exposing their patients to the sedation practices and monitoring protocols of their referral imaging center. A questionnaire regarding the sedation protocol for routine, outpatient, computed tomography or magnetic resonance imaging scans in children aged 5 years or younger was sent to staff radiologists at 36 pediatric medical centers throughout the United States. A variety of sedation practices were elicited. The complete survey results are presented, including monitoring practices, complication, and success rates. Despite concerns about its safety, chloral hydrate remains a frequently used and safe method of pediatric outpatient sedation.
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42

Bennett, Michelle. "Guidelines for sedation of the critically ill child." Paediatric Nursing 15, no. 9 (November 2003): 14–18. http://dx.doi.org/10.7748/paed.15.9.14.s23.

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43

OBARA, Katsutoshi. "Guidelines for Sedation in Gastrointestinal Endoscopy:Prevention of Malpractice." JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 38, no. 7 (November 15, 2018): 849–56. http://dx.doi.org/10.2199/jjsca.38.849.

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44

Bennett, Michelle. "Guidelines for sedation of the critically ill child." Paediatric Care 15, no. 9 (November 2003): 14–18. http://dx.doi.org/10.7748/paed2003.11.15.9.14.c666.

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45

Kim, Seung-Oh, and Jong-Su Kim. "Introduction of sedation guidelines and need for sedationist." JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY 39, no. 3 (August 31, 2012): 314–24. http://dx.doi.org/10.5933/jkapd.2012.39.3.314.

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46

Weaver, Joel M. "ADA Sedation-Anesthesia Guidelines Revisions Deserve our Support." Anesthesia Progress 54, no. 3 (September 2007): 99. http://dx.doi.org/10.2344/0003-3006(2007)54[99:asgrdo]2.0.co;2.

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47

Gotoda, Takuji, Takuji Akamatsu, Seiichiro Abe, Masaaki Shimatani, Yousuke Nakai, Waku Hatta, Naoki Hosoe, et al. "Guidelines for sedation in gastroenterological endoscopy (second edition)." Digestive Endoscopy 33, no. 1 (December 9, 2020): 21–53. http://dx.doi.org/10.1111/den.13882.

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48

Early, Dayna S., Jenifer R. Lightdale, John J. Vargo, Ruben D. Acosta, Vinay Chandrasekhara, Krishnavel V. Chathadi, John A. Evans, et al. "Guidelines for sedation and anesthesia in GI endoscopy." Gastrointestinal Endoscopy 87, no. 2 (February 2018): 327–37. http://dx.doi.org/10.1016/j.gie.2017.07.018.

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49

Vissers, Kris C. P. "Palliative Sedation: Need for Consensus Guidelines and Standards." Archives of Internal Medicine 170, no. 5 (March 8, 2010): 494. http://dx.doi.org/10.1001/archinternmed.2010.12.

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50

Dave, Manas, Ian Corbett, Graham Walton, and Kathy Wilson. "A review of good record keeping for conscious sedation in dentistry." Faculty Dental Journal 11, no. 2 (April 2020): 78–83. http://dx.doi.org/10.1308/rcsfdj.2020.78.

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Contemporaneous and thorough record keeping for conscious sedation in dentistry is good clinical practice; it is necessary to ensure patient safety and helps protect patients and clinicians (medicolegally). Clinicians providing a sedation service should be familiar with guidelines and their implementation. Record keeping for conscious sedation in dentistry is a useful audit topic in both primary and secondary care.
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