Relevant bibliographies by topics / Secretos – Novela

Academic literature on the topic 'Secretos – Novela'

Author: Grafiati
Published: 25 July 2024

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Journal articles on the topic "Secretos – Novela"

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Malaver Narváez, María Carmela. "El cuerpo perfumado. Los aromas de la intimidad femenina en Ifigenia (Teresa de la Parra, 1924)1." Corpo Grafías Estudios críticos de y desde los cuerpos 7, no. 7 (January 2, 2020): 92–106. http://dx.doi.org/10.14483/25909398.15508.

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El perfume y los olores tienen una especial relevancia en la novela Ifigenia (1924) de Teresa de la Parra. Este sutil elemento revela secretos de la sociedad desde el punto de vista sociológico, cultural, antropológico y comunica un mensaje. Se hará un breve recorrido por la historia del perfume. Desde esa base se hará una aproximación a la olfacción en la novela Ifigenia, donde el perfume y los olores aportan matices a la identidad de los personajes principales, develando secretos del alma de la casa criolla. Se utilizará la metodología interpretativa para analizar la relevancia del perfume en la obra y demostrar cómo la autora se vale de la olfacción para la construcción del sentido de la novela, descifrando un código para transmitir un mensaje. Nos serviremos de algunos teóricos de la olfacción, el perfume, el cuerpo y la identidad, entre ellos: Vroon, Corbin, Freud, Squicciarino, Foucault, Sáez, Mattalía, Torras.
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González, Begoña. "Relaciones violentas en Voci de Dacia Maraini." Revista Internacional de Culturas y Literaturas, no. 23 (2020): 61–73. http://dx.doi.org/10.12795/ricl.2020.i23.04.

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El objetivo de este artículo es un análisis de las difíciles relaciones que se establecen entre los personajes femeninos de una misma familia, madre e hijas, a causa de la violencia machista en la novela Voci de Dacia Maraini. Esta aparente novela negra, en realidad narra la violencia visible e invisible contra las mujeres, atrapadas en una red de secretos, mentiras y silencios para esconder una relación incestuosa por parte del padre.
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Burgos Cantor, Roberto. "Sobre La ceiba de la memoria." La Palabra y el Hombre, revista de la Universidad Veracruzana, no. 47 (August 23, 2019): 29–31. http://dx.doi.org/10.25009/lpyh.v0i47.2801.

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"A finales de 2017, el recientemente fallecido Roberto Burgos Cantor tuvo una participación en la Universidad de Nantes, Francia, a propósito de La ceiba de la memoria, en la que muestra algunos de los secretos que implicó la elaboración de esta novela, considerada uno de sus mejores trabajos literarios."
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Kürthy, Ádám András. "Secretos, equívocos, narradores y espacios: reflexiones sobre la novela corta El acoso y las tesis de Piglia." Lejana. Revista Crítica de Narrativa Breve, no. 13 (February 19, 2020): 90–100. http://dx.doi.org/10.24029/lejana.2020.13.433.

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El presente artículo toma como punto de partida tres textos de índole teórica de Ricardo Piglia sobre el género del cuento y el de la novela corta, para aplicar sus afirmaciones a la observación de un texto literario, El acoso de Alejo Carpentier, buscando ver así las limitaciones y los aciertos de sus tesis. El acoso, interpretado aquí como novela corta, queda luego brevemente comparado con otras obras carpenterianas, cuento y novela, para ver qué solidez tienen los límites dibujados a base de las ideas de Piglia, con algún que otro suplemento derivado de la contrastación de las tesis con la obra literaria.
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Zavala Corona, Regina. "Los espacios cerrados en Christine Falls, de Benjamin Black." Nuevas Poligrafías. Revista de Teoría Literaria y Literatura Comparada, no. 9 (April 22, 2024): 34–50. http://dx.doi.org/10.22201/ffyl.29544076.2024.9.1987.

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Este artículo propone analizar la novela negra de Benjamin Black, Christine Falls, a partir de los espacios cerrados que se describen a lo largo de la historia. Lo anterior se hace para demostrar que en estos lugares se esconde la corrupción de la élite dublinesa y una vez que el detective (Quirke) logra entrar en ellos, los secretos se revelan. Para lo anterior, se utilizan conceptos de teoría sobre el espacio narrativo y de la perspectiva de los personajes; además de teoría de la ficción detectivesca, ya que contribuyen a la creación del ambiente característico de la novela noir. Así pues, después de establecer las bases teóricas del análisis, se examinan distintos pasajes de la novela (focalizados en varios de los personajes que desempeñan un rol importante en la trama) que son claves para que el detective resuelva el caso. También se estudian algunas condiciones sociohistóricas de los años cincuenta en Irlanda, ya que éstas ayudan a explicar las acciones y percepciones de varios de los personajes de la novela. Por último, se reflexiona sobre la importancia del género detectivesco, particularmente el de la novela negra, como herramienta de crítica social, ya que expone y cuestiona a las esferas de poder que constantemente tratan de silenciar a grupos vulnerables de la urbe.
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Wahnón, Sultana. "La metaficción en Cien años de soledad: sobre los manuscritos de Melquíades." Archivo Vallejo 7, no. 13 (January 30, 2024): 263–87. http://dx.doi.org/10.59885/archivovallejo.2024.v7n13.12.

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Este trabajo profundiza en el carácter metaficcional de los manuscritos de Melquíades, con el objetivo de explicar en qué consiste exactamente el juego de semejanzas y diferencias entre la novela y el texto que la dobla a manera de relato especular. Partiendo de su conocida hipótesis sobre el origen judío de los Buendía, la autora de este trabajo defiende, con argumentos teóricos y comparatistas, que el espectacular final de la novela, en el que Aureliano Babilonia descubre las claves de Melquíades y accede así al enigma contenido en los manuscritos, no sería sino una prefiguración del acto de lecturainterpretación requerido por la propia novela, ella misma concebida y ejecutada a manera de texto enigmático y descifrable. Polemizando tácitamente con las más recientes teorías de la interpretación, el escritor habría creado así la inusual imagen de un texto que, lejos de estar destinado a la interpretación infinita, brindaría al lector la posibilidad de descubrir y revelar sus más cruciales secretos.
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Rodríguez Mansilla, Fernando. "La interpretación cervantina de Roberto Bolaño en El Tercer Reich." Cuadernos Literarios 14, no. 17 (December 1, 2020): 9–19. http://dx.doi.org/10.35626/cl.17.2020.281.

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Este trabajo explora la presencia de Miguel de Cervantes y Don Quijote de la Mancha en la novela El Tercer Reich de Roberto Bolaño. Como el hidalgo enajenado, su protagonista, Udo Berger, vive dentro de la fantasía de los juegos de estrategia bélica, especialmente aquel llamado El Tercer Reich, cuyos secretos se propone analizar. Su pasión por el juego, su idealismo y el desapego a la realidad que se cierne a su alrededor lo asemejan a un don Quijote que terminará vencido en lasplayas de Cataluña.
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Herrera Ávila, Tatiana. "Jardines del cuerpo que se fragmenta." Revista de Filología y Lingüística de la Universidad de Costa Rica 39, no. 1 (March 17, 2014): 139. http://dx.doi.org/10.15517/rfl.v39i1.13860.

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En este artículo, se presentará un análisis en torno al tema de la fragmentación del cuerpo de la amada que hace el sujeto enamorado en su discurso amoroso. Para ello, se tomará como eje central el caso de la novela Los jardines secretos de Mogador del escritor mexicano Alberto Ruy Sánchez, y se partirá fundamentalmente de los postulados teóricos que Roland Barthes expone en Fragmentos de un discurso amoroso, aunque también se tomarán como puntos de partida algunas nociones centrales del psicoanálisis freudiano, tales como la imposibilidad de la completud y el cuerpo como límite del sujeto.
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De Pablos Trigo, Elena. "Pequeño cerebro de avispa, pájaro raro: el universo faunístico en "Piel de lobo" de Lara Moreno." Cuadernos de Investigación Filológica 44 (November 12, 2018): 163. http://dx.doi.org/10.18172/cif.3439.

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Este artículo aborda el universo faunístico en Piel de lobo de Lara Moreno. Las constantes animalizaciones y los juegos narrativos con insectos y mamíferos enaltecen una obra que trata sobre la huida, la soledad, la maternidad y la familia, y que confronta, como en su novela anterior, Por si se va la luz, la urbe con el mundo rural. Los saltos temporales entre presente y pasado, y la peculiar narrativa de la autora, vertiginosa y abrupta en ocasiones, amparan una historia sórdida rebosante de secretos y silencios, la cual será enmascarada en avispas, lobos, corderos, pájaros, y tigres que se transforman en perros.
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López-Aguilar, Miguel de Alba. "Un acercamiento a la novela histórica Secretos de la Inquisición de Joaquín María Nin Miguel de Alba López-Aguilar." Cuadernos de Ilustración y Romanticismo, no. 13 (2005): 201–13. http://dx.doi.org/10.25267/cuad_ilus_romant.2005.i13.09.

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Dissertations / Theses on the topic "Secretos – Novela"

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Oyola, Valdez Daniela Isabel. "Las polémicas sobre el Inca Garcilaso : textualidad, contra-escritura y novela en Poderes Secretos de Miguel Gutiérrez." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2019. http://hdl.handle.net/20.500.12404/14572.

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En la presente investigación, analizo las construcciones ficcionales que en Poderes secretos (2009) de Miguel Gutiérrez se realizan de figuras y eventos de gran centralidad que pertenecen o tratan sobre el contexto temprano de la conquista y colonización de los Andes. Sostengo que el narrador de la trama, escritor de una novela en proceso de creación, construye una ficción de las denominadas “polémicas sobre la posesión de las Indias” a partir de la polémica en torno a la biografía del Inca Garcilaso de la Vega y la autoría de sus Comentarios reales, para demostrar la actualidad del ejercicio textual de la violencia colonial. La cuestión del mestizaje, tema central de la discusión contemporánea sobre la identidad nacional peruana, es concebida por la voz narradora como la continuación del problema del indio originado en el contexto de la colonización americana, cuyo tratamiento se caracterizó por ser polémico y textual. Mediante la construcción o, como concretamente entiendo, la novelización de este fenómeno discursivo colonial, la novela, en tanto género literario, es propuesta en la obra como el único espacio discursivo capaz de hacer resistencia a la violencia de la Historia oficial, esto es, como un discurso textual constitutivamente político.
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Spiewak, H. L. "Identifying novel secreted effectors of the type VI protein secretion system in Burkholderia cenocepacia." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/11777/.

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Port, Gary C. "Exploring the Listeria monocytogenes secretome : identification and functional characterization of novel virulence factors and secretion systems /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/4981.

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Herrera, Manzo Víctor. "Del repliegue al reflejo : El hipogeo secreto de Salvador Elizondo." Tesis, Universidad de Chile, 2014. http://www.repositorio.uchile.cl/handle/2250/116122.

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Lefebvre, Karen. "Identification of novel PTEN-regulated secreted factors." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97210.

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PTEN, the most frequently mutated gene in human prostate cancer, is atumour suppressor that inhibits angiogenesis by regulating the expression ofseveral pro- and anti-angiogenic factors. The goal of this project was to identifynovel angiogenic factors and other secreted proteins that are regulated by PTEN.Proteomics techniques were employed to identify proteins that were differentiallyexpressed in the conditioned media of PTEN-null and PTEN-expressing humanprostate cancer cells. 16 proteins were identified, 4 of which were up-regulatedby PTEN and 12 of which were down-regulated by PTEN. Gene expressionanalysis and polysome profiling revealed that 2 proteins were transcriptionallyregulated by PTEN and 5 proteins were regulated at the level of translation.Three of the PTEN-regulated factors identified in this study, spondin 2 (SPO2),Zn-alpha-2-glycoprotein (ZAG), and cystatin C (CST3) are up-regulated invarious cancers and could be useful serum biomarkers for the diagnosis ofprostate cancer.
PTEN est un gène supresseur de tumeur. Il est fréquemment muté chez leshumains ayant un cancer de la prostate. Un de ses rôles est d'inhiberl'angiogénèse en régulant l'expression de plusieurs facteurs pro- et antiangiogéniques.L'objectif de cette étude était d'identifier de nouveaux facteursangiogéniques et de nouvelles protéines secretées qui sont régulés par cetteprotéine. L'utilisation de différentes techniques protéomiques, sur le milieu deculture de cellules prostatiques cancéreuses, nous a permis d'identifier 16protéines ayant des niveaux d'expression différents selon que la protéine al'étude, PTEN, était ou non exprimée. Parmi elles, 4 ont un niveau d'expressionmoindre en présence de la protéine PTEN alors que les 12 autres présentent unniveau d'expression plus élevé. L'analyse du profil de polysomes et del'expression génique pour 7 d'entre elles montrent que la protéine PTEN enrégule deux au niveau transcriptionnel et cinq au niveau traductionnel. La forteexpression de trois protéines identifiées dans cette étude, spondin 2 (SPO2), Znalpha-2-glycoprotein (ZAG), et cystatin C (CST3), dans plusieurs cancers pourraitles qualifier comme nouveaux biomarqueurs dans le diagnostique du cancer de laprostate.
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McClenaghan, Neville Hugo. "Studies of novel insulin-secreting cell lines." Thesis, University of Ulster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284850.

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Trauth, Erin. "Tumbleweed Road: A Novel." Scholar Commons, 2010. https://scholarcommons.usf.edu/etd/1794.

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Tumbleweed Road is a novel that began as a short story in a fiction workshop many years ago. The novel is set in the contemporary American South and traces one tumultuous summer in the life of a 14-year-old girl named Carolina Wells. The plot of the story is as follows: Carolina, a 14-year-old girl from Crow, Florida, does not understand her mother and remembers little about her past. In the story, we meet Carolina, her mother, "Mama," and two brothers, Johnny and Austin. Carolina does not understand her mother and her wild nature. At home, Carolina is forced to care for her two younger brothers. Carolina's father is long gone out of the picture, and Carolina was always told by her mother that she has no father - no one worth speaking of, anyway. Carolina can't remember why her father is gone, but remembers the fight that caused him to leave, and she blames her mother entirely for his leaving when she was just a toddler. Carolina questions her Mama about the disappearance of her father, but she refuses to even speak his name. Carolina desperately wants normalcy, family, and love - through a series of life-changing events involving a range of characters, including a spiritual woman across Tumbleweed Road, a mysterious girl named West and an old friend named Cade, this novel is about Carolina's quest to find her place in this world.
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Trezza, Alfonso. "A novel computational way to unlock drug targets deep and transient secretes." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1072788.

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Sargsyan, Ernest. "Characterization of ERp29, a novel secretion factor of endoplasmic reticulum /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-337-X/.

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Ribeiro, Furtado Ana Rita. "A novel Chlamydia pneumoniae secreted protein with putative deubiquitinating activity." Paris 7, 2010. http://www.theses.fr/2010PA077085.

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Chlamydia pneumoniae est une bactérie pathogène pour l'Homme. Cette espèce est un des principaux agents bactériens responsables de pneumopathies atypiques communautaires. Elle est également associée à des maladies chroniques comme l'athérosclérose. La multiplication des bactéries a lieu dans un compartiment délimité par une membrane, l'inclusion. Elles sont également capables de déjouer des défense; de l'hôte, et de détourner certaines des fonctions cellulaires à leur profit. L'appareil de sécrétion, dit de type trois (STT) joue à ce niveau un rôle prépondérant. Ce travail constitue la première étude de la protéine hypothétique de C. Pneumoniae, CPn0483. Cette protéine est un nouvel effecteur de la sécrétion de type III, conservée chez les Chlamydophila et absente des Chlamydia. CPn0483 présente le domaine OTU, qui peut conférer une activité de protéase à cystéine Bien que nous n'ayons pas démontré cette même activité contre des substrats d'ubiquitine, l'interaction de CPn0483 avec des sondes d'ubiquitine suggère fortement que CPn0483 puisse posséder l'activité de désubiquitination. Également, nous avons confirmé l'interaction entre CPn0483 et NDP52. À l'heure actuelle, nous testons la signification biologique de cette interaction au cours de l'infection de cellules eucaryotes par C. Pneumoniae. CPn0483 pourrait donc jouer un rôle important dans l'adaptation des Chlamydophila à leurs hôtes
Chlamydia pneumoniae is an obligate intracellular bacterial pathogen that is a causative agent for several human respiratory diseases and is also associated with chronic diseases, such as atherosclerosis. These bacteria survive within a membrane compartment, the inclusion, from where they are capable of diverting host cellular mechanisms for their own benefit. As other Gram-negative pathogenic bacteria, C. Pneumoniae possess genes coding for a type III secretion (TTS) System that allows translocation of bacterial proteins into their host. These proteins are of great interest because of their possible role in virulence and persistence within the host. We have identified the chlamydial protein CPn0483 as a type III secretion substrate. The séquence analysis of CPn0483 and its orthologs in chlamydiae led to the identification of an ovarian tumor (OTU) protease motif in their amino termini. Members of the OTU family of proteases that are found in eukaryotes and viruses, have been shown to have deubiquitinase activity. CPn0483 reacts with activity-based probes directed against deubiquitinases, further supporting the hypothesis that this bacterial protein has deubiquitinase activity. A yeast two-hybrid screen identified NDP52 (nuclear dot protein 52) as a protein capable of interacting with CPn0483. We were able to validate a NDP52 as protein partner of CPN0483 by immunoprecipitation and GST-pulldown. Thus, we have identified a novel type III effector protein of Chlamydia pneumoniae and one of its cellular targets, the protein NDP52. Considering its kinetics of expression, CPnQ483 could play a role late in the infectious cycle, or very early during the next round of infection
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Books on the topic "Secretos – Novela"

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Montemayor, Carlos. Los informes secretos: Novela. México: J. Mortiz, 1999.

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Lauer, Mirko. Secretos inútiles: Una novela. Lima: Hueso Húmero Ediciones, 1991.

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Lauer, Mirko. Secretos inútiles: Una novela. Lima: Hueso Húmero Ediciones, 1991.

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Kemplin, Mildred Bolaños. Secretos de convento: Novela histórica. 2nd ed. La Antigua Guatemala: [s.n.], 2009.

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Tortonese, Darcy. Los secretos de La Perichona: Novela. Buenos Aires: Editorial Nueva Generación, 2002.

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Parker, C. L. Un millón de secretos inconfesables. Barcelona: Sombras, 2014.

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Danielle, Steel. Secretos. México, D. F: Grijalbo, 1987.

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Asher, Bridget. Secretos en la Provenza. Barcelona: Ediciones B, 2013.

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El secreto del tío Óscar. [Charleston, S.C.]: Fernando Trujillo, 2011.

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Fernanda y los mundos secretos. México, D.F: Fondo de Cultura Económica, 2004.

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Book chapters on the topic "Secretos – Novela"

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Peach, Linden. "Secret Hauntings." In The Contemporary Irish Novel, 38–67. London: Macmillan Education UK, 2004. http://dx.doi.org/10.1007/978-1-4039-3854-1_3.

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Conrad, Joseph. "The Secret Agent." In Joseph Conrad: Three Novels, 93–338. London: Macmillan Education UK, 1995. http://dx.doi.org/10.1007/978-1-349-23831-6_2.

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Spittles, Brian. "The Secret Agent (1907)." In How to Study a Joseph Conrad Novel, 64–84. London: Macmillan Education UK, 1990. http://dx.doi.org/10.1007/978-1-349-10859-6_5.

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Dalley, Hamish. "Typification and Frontier Violence: Kate Grenville’s The Secret River." In The Postcolonial Historical Novel, 45–69. London: Palgrave Macmillan UK, 2014. http://dx.doi.org/10.1057/9781137450098_3.

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Yan, Xuehu, Shen Wang, Ahmed A. Abd El-Latif, Jianzhi Sang, and Xiamu Niu. "A Novel Perceptual Secret Sharing Scheme." In Transactions on Data Hiding and Multimedia Security IX, 68–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-55046-1_5.

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Salmons, Kim. "Anarchy, Vegetarianism and The Secret Agent." In Food in the Novels of Joseph Conrad, 83–96. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56623-8_5.

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Tanaka, K., and H. Arita. "Secretory phospholipase A2 inhibitors. Possible new antiinflammatory agents." In Novel Molecular Approaches to Anti-Inflammatory Therapy, 51–64. Basel: Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7276-8_6.

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Ramachandran, J., K. Nikolics, and P. H. Seeburg. "A Novel Hypothalamic Peptide Inhibitor of Prolactin Secretion." In Contraception Research for Today and the Nineties, 101–13. New York, NY: Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3746-4_10.

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Bu, Shanyue, and Ronggeng Yang. "Novel and Effective Multi-Secret Sharing Scheme." In Lecture Notes in Electrical Engineering, 461–67. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4853-1_58.

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Mulry, David. "The Dynamite Novel and The Secret Agent." In Joseph Conrad Among the Anarchists, 73–101. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-137-49585-3_4.

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Conference papers on the topic "Secretos – Novela"

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Libby, Peter, Stephen J. C. Warner, and Louis K. Birinyi. "THE VESSEL WALL AS A SOURCE OF VASORHGOLATORY AND IMMDNOSTIMOLATORY CYTOKINES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643982.

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The cytokines Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF, also known as cachectin) exhibit multiple effects on circulating blood cells and cells of the blood vessel wall. For example, these mediators elicit a coordinated Drogram of functions of endothelial cells (EC) that promotes blood coagulation and thrombosis, and lead to clot stabilization. Furthermore, IL-1 and TNF promote adherence to vascular endothelium of leukocytes of many classes.Thus, these cytokines are likely to be involved in signaling the pathologic changes in blood vessels that characterize a number of inflammatory or infectious processes. These two cytokines were originally isolated frcm activated human mononuclear phagocytes, hence their comnon designation as monokines and the terminology "interleukin". However, recent findings have broadened this concept considerably. It is now clear that many cell types can produce IL-1-1ike activity.Several groups showed that human vascular EC can secrete material that stimulates proliferation of thymocytes incubated with suboptima1 doses of the mitogenic lectin phytohemagglutinin, a typical acitivty of IL-1 (thymocyte costimulation).Two related but distinct genes cloned frcm human peripheral blood monocytes encode IL-1 molecules. In human blood monocytes stimulated with bacterial lioopolysaccharide (LPS) IL-1 beta (pi ∼ 7) is the major form expressed while IL-1 alpha (pi ∼ 5) is the less abundant species secreted by human monocytes under these conditions. We found that EC and smooth muscle cells (SMC) isolated from adult human vessels can express these same IL-1 genes. LPS, a standard stimulus to IL-1 secretion in the monocyte, caused accumulation of IL-1 beta mRNA in both vascular cell types. Endothelial cells frcm adult human vessels also contained IL-1 alpha mRNA when treated with LPS in the presence of cycloheximide and LPS-stimulated smooth muscle cells contained RNA that hybridized with an IL-1 alpha cDNA probe as well. Although both vascular cell types can transcribe these IL-1 genes, the time course of this response differs. LPS induced IL-1 beta mRNA production by SMC maximally at 4-6 hr., whereas maximal IL-1 induction by LPS in EC occured 1 day after initiation of the exposure. Actinanycin D (1 ug/ml) blocked 3H-uridine incorporation into macromolecules by > 95% in both EC & SMC, and prevented the LPS-induced increases in IL-1 mRNA levels in these cells. This result suggests that this potentially injurious stimulus causes IL-1 mRNA accumulation by an increase in rates of transcription. These LPS-induced increases in IL-1 mRNA levels corresponded to production of biologically active IL-1 determined as thymocyte costimulation activity. Interestingly, gel filtration experiments revealed a molecular weight of around 22kD for both SMC and EC-derived IL-1 secreted into culture medium in response to LPS. This molecular weight contrasts with the 17 kD species which is the fully processed product secreted frcm activated human monocytes. A possible explanation for this disparity is that the vascular cells secrete a partially processed intermediate form of mature IL-1. Other stimuli for IL-1 mRNA accumulation and secretion of biological activity include TNF and IL-1 itself. Recombinant human INF (≥ 10 ng/ml) increased IL-1 beta mRNA levels in EC & SMC, and caused the EC & SMC to release IL-1-1 ike thymocyte costimulation activity. Of interest is the recent observation that IL-1 itself can stimulate expression of IL-rl genes in vascular wall cells. Both IL-1 aloha and beta can increase IL-1 beta mRNA content in EC & SMC. Hris observation was confirmed with homogenous IL-1 prepared by recombinant DNA technologies (rIL-1). These findings raise the possibility of a novel positive feedback loop in vascular pathophysiology. We also found that rIL-1 alpha or beta also induced the production of prostaglandin E2 (PGE2) by both vascular SMC & EC. This prostanoid, induced by IL-1, inhibits thymocyte _ proliferation. Thus, IL-1 not only induced its own expression but increased production of this immunosuppressive prostanoid. This mechanism provides a potential negative control loop in regulation of the local immune response in blood vessels. Vie conclude that these cells of the blood vessel wall are a source of the potent vasoregulatory and immune mediators IL-1 alpha and beta. Since IL-1 influences the thrombotic, hemostatic, and fibrinolytic functions of endothelium, as well as other responses to acute injury, our findings suggest novel local control mechanisms that may be important in a variety of pathologic states.
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Anbarasi, L. Jani, M. Jenila Vincent, and G. S. Anandha Mala. "A novel visual secret sharing scheme for multiple secrets via error diffusion in halftone visual cryptography." In 2011 International Conference on Recent Trends in Information Technology (ICRTIT). IEEE, 2011. http://dx.doi.org/10.1109/icrtit.2011.5972436.

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Konygin, Anton, Andrey Kopnin, Ilya Mezentsev, and Alexandr Pankratov. "Using Bigrams to Detect Leaked Secrets in Source Code." In 18th International Conference on Evaluation of Novel Approaches to Software Engineering. SCITEPRESS - Science and Technology Publications, 2023. http://dx.doi.org/10.5220/0011983600003464.

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Al-Mohannadi, Anjud Khamis, Sara Deola, and Ahmed Malki. "Visualization of Factor Viii with Flow-Cytometry as a tool for Novel Gene Therapy Approach in Hemophilia A." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0164.

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Haemophilia A is a genetic X-linked disorder, characterized by coagulation Factor VIII (FVIII) deficiency and leading to pathological bleedings. The disease occurs at a rate of 1 in 5000 males’ births. The treatment is the administration of plasma-derived or recombinant Factor VIII, which is expensive and leads to the development of inhibitory antibodies in around 40% of patients affected by the severe form of the disease. The disease becomes for these patients as life threatening. In new approaches to treat Haemophilia include gene therapy (GT), cells corrected through genetic modifications are used to produce in Haemophilia A patients FVIII protein in a sustained manner, as long-term treatment for this disorder. The cells of choice should be persistent and equipped with themachinery for large protein assembly and secretion. So far, target cells for Haemophilia gene correction are mostly liver cells, although they are highly immunogenic and exposed to immune-mediated destruction after GT. Based on literature evidences, bone marrow transplantation can correct Haemophilia A in mice, providing evidence that Hematopoietic stem cells (HSC) or their progeny are able to produce FVIII. We chose the approach of correcting HSC with lentiviral vectors carrying the FVIII gene cassette. Whereas classically FVIII protein is visualized on adherent cells through immunohistochemistry staining, flow-cytometry (FC) literature publications are very scarce. FC analysis is an attractive method for analysing hematopoietic cells, and in general, a versatile method for protein visualization. However, large proteins as FVIII are difficult to be carefully analysed, and the method requires several steps of optimization. This joint project with Dr. Muhammad Elnaggar, aims to optimize a method to characterize large proteins as FVIII with a reliable FC staining protocol. To this aim, we used cell lines to evaluate the expression and secretion pathways of FVIII, the intracellular requirements to fold and secrete large proteins, and the toxicities of protein accumulation, in case of GT mediated protein overexpression. For this purpose, the FC experiments were performed to optimise the FC protocol for FVIII visualization, by improving blocking efficacy, antibody-labelling efficacy and to ensure accuracy and validity through qPCR and FC double staining. This FC protocol proved its validity and usefulness in visualizing and studying functionally FVIII.
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Takahashi, Nozomi, Hiromi Nakamura, Takuji Narumi, Michitaka Hirose, and Kazuma Aoyama. "Electrical Stimulation Promotes Saliva Secretion: Proposition of Novel Interaction via Saliva Secretion." In CHI '20: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3334480.3382952.

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Zhong, Hua, Fang Liu, and Licheng Jiao. "Novel secret-key watermarking system." In Multispectral Image Processing and Pattern Recognition, edited by Jun Tian, Tieniu Tan, and Liangpei Zhang. SPIE, 2001. http://dx.doi.org/10.1117/12.442899.

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Yu, Yang, Michail Moraitis, and Elena Dubrova. "Why Deep Learning Makes it Difficult to Keep Secrets in FPGAs." In DYNAMICS 2020: 2020 Workshop in DYnamic and Novel Advances in Machine Learning and Intelligent Cyber Security. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3477997.3478001.

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Naskar, Prabir Kr, Ayan Chaudhuri, Debarati Basu, and Atal Chaudhuri. "A Novel Image Secret Sharing Scheme." In 2011 Second International Conference on Emerging Applications of Information Technology (EAIT). IEEE, 2011. http://dx.doi.org/10.1109/eait.2011.43.

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Lin, S. D., and Shih-Chieh Shie. "A novel secret image transmission scheme." In 2005 Digest of Technical Papers. International Conference on Consumer Electronics, 2005. ICCE. IEEE, 2005. http://dx.doi.org/10.1109/icce.2005.1429860.

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Paixão, Thiago M., Maria C. S. Boeres, and Thiago Oliveira-Santos. "Unveiling the Secrets: Reconstruction of Shredded Documents using Deep Learning." In Anais Estendidos da Conference on Graphics, Patterns and Images. Sociedade Brasileira de Computação - SBC, 2023. http://dx.doi.org/10.5753/sibgrapi.est.2023.27451.

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This work addresses the intricate task of reconstructing mechanically-shredded documents with potential application in forensic investigation. Our primary contributions consist of two novel deep learning approaches for fully automatic reconstruction tested on real-world shredded data that achieved state-of-the-art accuracy in more realistic scenarios. As a second major contribution, we introduce a novel framework for semi-automatic reconstruction inspired by the principles of active learning. The core of our proposal is a recommendation module that smartly flags potential errors in the reconstruction output (permutation of shreds) for human review, enabling even more enhanced reconstructions. The mentioned contributions and additional outcomes (datasets and experimental protocols) resulted in five relevant publications: three journal articles and two international conferences, including the premier IEEE / CVF Computer Vision and Pattern Recognition Conference (CVPR).
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Reports on the topic "Secretos – Novela"

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Koeffler, H. P. Identification of Novel Secreted Molecules of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, June 1999. http://dx.doi.org/10.21236/ada371233.

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Elbaum, Michael, and Peter J. Christie. Type IV Secretion System of Agrobacterium tumefaciens: Components and Structures. United States Department of Agriculture, March 2013. http://dx.doi.org/10.32747/2013.7699848.bard.

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Objectives: The overall goal of the project was to build an ultrastructural model of the Agrobacterium tumefaciens type IV secretion system (T4SS) based on electron microscopy, genetics, and immunolocalization of its components. There were four original aims: Aim 1: Define the contributions of contact-dependent and -independent plant signals to formation of novel morphological changes at the A. tumefaciens polar membrane. Aim 2: Genetic basis for morphological changes at the A. tumefaciens polar membrane. Aim 3: Immuno-localization of VirB proteins Aim 4: Structural definition of the substrate translocation route. There were no major revisions to the aims, and the work focused on the above questions. Background: Agrobacterium presents a unique example of inter-kingdom gene transfer. The process involves cell to cell transfer of both protein and DNA substrates via a contact-dependent mechanism akin to bacterial conjugation. Transfer is mediated by a T4SS. Intensive study of the Agrobacterium T4SS has made it an archetypal model for the genetics and biochemistry. The channel is assembled from eleven protein components encoded on the B operon in the virulence region of the tumor-inducing plasmid, plus an additional coupling protein, VirD4. During the course of our project two structural studies were published presenting X-ray crystallography and three-dimensional reconstruction from electron microscopy of a core complex of the channel assembled in vitro from homologous proteins of E. coli, representing VirB7, VirB9, and VirB10. Another study was published claiming that the secretion channels in Agrobacterium appear on helical arrays around the membrane perimeter and along the entire length of the bacterium. Helical arrangements in bacterial membranes have since fallen from favor however, and that finding was partially retracted in a second publication. Overall, the localization of the T4SS within the bacterial membranes remains enigmatic in the literature, and we believe that our results from this project make a significant advance. Summary of achievements : We found that polar inflations and other membrane disturbances relate to the activation conditions rather than to virulence protein expression. Activation requires low pH and nutrient-poor medium. These stress conditions are also reflected in DNA condensation to varying degrees. Nonetheless, they must be considered in modeling the T4SS as they represent the relevant conditions for its expression and activity. We identified the T4SS core component VirB7 at native expression levels using state of the art super-resolution light microscopy. This marker of the secretion system was found almost exclusively at the cell poles, and typically one pole. Immuno-electron microscopy identified the protein at the inner membrane, rather than at bridges across the inner and outer membranes. This suggests a rare or transient assembly of the secretion-competent channel, or alternatively a two-step secretion involving an intermediate step in the periplasmic space. We followed the expression of the major secreted effector, VirE2. This is a single-stranded DNA binding protein that forms a capsid around the transferred oligonucleotide, adapting the bacterial conjugation to the eukaryotic host. We found that over-expressed VirE2 forms filamentous complexes in the bacterial cytoplasm that could be observed both by conventional fluorescence microscopy and by correlative electron cryo-tomography. Using a non-retentive mutant we observed secretion of VirE2 from bacterial poles. We labeled the secreted substrates in vivo in order detect their secretion and appearance in the plant cells. However the low transfer efficiency and significant background signal have so far hampered this approach.
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Wreschner, Daniel H. Analysis of the Secreted Novel Breast-Cancer-Associated MUC1/Zs Cytokine. Fort Belvoir, VA: Defense Technical Information Center, June 2001. http://dx.doi.org/10.21236/ada397081.

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Miele, Lucio. Gamma-Secretase and Notch Signaling: Novel Therapeutic Targets In Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2005. http://dx.doi.org/10.21236/ada446389.

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Wreschner, Daniel H. Analysis of the Secreted Novel Breast-Cancer-Associated MUC1/Zs Cytokine. Fort Belvoir, VA: Defense Technical Information Center, June 2003. http://dx.doi.org/10.21236/ada425838.

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Keyes, Thomas. Combining Novel Simulation Methods and Nucleation Theory to Uncover the Secrets of Gas Hydrates. Office of Scientific and Technical Information (OSTI), April 2016. http://dx.doi.org/10.2172/1247317.

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Lemmon, Mark A. Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment. Fort Belvoir, VA: Defense Technical Information Center, April 2007. http://dx.doi.org/10.21236/ada471085.

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Yang, Dajun. Testing Clinical Relevance and Therapeutic Potential of a Novel Secreted Ligand of TNF Family. Fort Belvoir, VA: Defense Technical Information Center, September 2002. http://dx.doi.org/10.21236/ada424660.

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Coplin, David, Isaac Barash, and Shulamit Manulis. Role of Proteins Secreted by the Hrp-Pathways of Erwinia stewartii and E. herbicola pv. gypsophilae in Eliciting Water-Soaking Symptoms and Initiating Galls. United States Department of Agriculture, June 2001. http://dx.doi.org/10.32747/2001.7580675.bard.

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Many bacterial pathogens of plants can inject pathogenicity proteins into host cells using a specialized type III secretion system encoded by hrpgenes. This system deliver effector proteins, into plant cells that function in both susceptible and resistant interactions. We have found that the virulence of Erwinia stewartii(Es; syn. Pantoea stewartii) and Erwinia herbicola pv. gypsophilae (Ehg, syn. Pantoea agglomerans), which cause Stewart's wilt of corn and galls on Gypsophila, respectively, depends on hrpgenes. The major objectives of this project were: To increase expression of hrpgenes in order to identify secreted proteins; to identify genes for proteins secreted by the type-III systems and determine if they are required for pathogenicity; and to determine if the secreted proteins can function within eukaryotic cells. We found that transcription of the hrp and effector genes in Es and Ehg is controlled by at least four genes that constitute a regulatory cascade. Environmental and/or physiological signaling appears to be mediated by the HrpX/HrpY two component system, with HrpX functioning as a sensor-kinase and HrpY as a response regulator. HrpYupregulateshrpS, which encodes a transcriptional enhancer. HrpS then activates hrpL, which encodes an alternate sigma factor that recognizes "hrp boxes". All of the regulatory genes are essential for pathogenicity, except HrpX, which appears only to be required for induction of the HR in tobacco by Es. In elucidating this regulatory pathway in both species, we made a number of significant new discoveries. HrpX is unusual for a sensor-kinase because it is cytoplasmic and contains PAS domains, which may sense the redox state of the bacterium. In Es, a novel methyl-accepting protein may function upstream of hrpY and repress hrp gene expression in planta. The esaIR quorum sensing system in Es represses hrp gene expression in Es in response to cell-density. We have discovered six new type III effector proteins in these species, one of which (DspE in Ehg and WtsE in Es) is common to both pathogens. In addition, Es wtsG, which is a homolog of an avrPpiB from P. syringae pv. pisi, and an Ehg ORF, which is a homolog of P. syringae pv. phaseolicola AvrPphD, were both demonstrated to encode virulence proteins. Two plasmidborne, Ehg Hop proteins, HsvG and PthG, are required for infection of gypsophilia, but interestingly, PthG also acts as an Avr elicitor in beets. Using a calmodulin-dependent adenylate cyclase (cyaA) reporter gene, we were successful in demonstrating that an HsvG-CyaA fusion protein can be transferred into human HeLa cells by the type-III system of enteropathogenic E. coli. This is a highly significant accomplishment because it is the first direct demonstration that an effector protein from a plant pathogenic bacterium is capable of being translocated into a eukaryotic cell by a type-III secretion system. Ehg is considered a limiting factor in Gypsophila production in Israel and Stewart’s Wilt is a serious disease in the Eastern and North Central USA, especially on sweet corn in epidemic years. We believe that our basic research on the characterization of type III virulence effectors should enable future identification of their receptors in plant cells. This may lead to novel approaches for genetically engineering resistant plants by modifying their receptors or inactivating effectors and thus blocking the induction of the susceptible response. Alternatively, hrp gene regulation might also provide a target for plant produced compounds that interfere with recognition of the host by the pathogen. Such strategies would be broadly applicable to a wide range of serious bacterial diseases on many crops throughout the USA and Israel.
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Brown Horowitz, Sigal, Eric L. Davis, and Axel Elling. Dissecting interactions between root-knot nematode effectors and lipid signaling involved in plant defense. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7598167.bard.

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Root-knot nematodes, Meloidogynespp., are extremely destructive pathogens with a cosmopolitan distribution and a host range that affects most crops. Safety and environmental concerns related to the toxicity of nematicides along with a lack of natural resistance sources threaten most crops in Israel and the U.S. This emphasizes the need to identify genes and signal mechanisms that could provide novel nematode control tactics and resistance breeding targets. The sedentary root-knot nematode (RKN) Meloidogynespp. secrete effectors in a spatial and temporal manner to interfere with and mimic multiple physiological and morphological mechanisms, leading to modifications and reprogramming of the host cells' functions, resulted in construction and maintenance of nematodes' feeding sites. For successful parasitism, many effectors act as immunomodulators, aimed to manipulate and suppress immune defense signaling triggered upon nematode invasion. Plant development and defense rely mainly on hormone regulation. Herein, a metabolomic profiling of oxylipins and hormones composition of tomato roots were performed using LC-MS/MS, indicating a fluctuation in oxylipins profile in a compatible interaction. Moreover, further attention was given to uncover the implication of WRKYs transcription factors in regulating nematode development. In addition, in order to identify genes that might interact with the lipidomic defense pathway induced by oxylipins, a RNAseq was performed by exposing M. javanicasecond-stage juveniles to tomato protoplast, 9-HOT and 13-KOD oxylipins. This transcriptome generated a total of 4682 differentially expressed genes (DEGs). Being interested in effectors, we seek for DEGs carrying a predicted secretion signal peptide. Among the DEGs including signal peptide, several had homology with known effectors in other nematode species, other unknown potentially secreted proteins may have a role as root-knot nematodes' effectors which might interact with lipid signaling. The molecular interaction of LOX proteins with the Cyst nematode effectors illustrate the nematode strategy in manipulating plant lipid signals. The function of several other effectors in manipulating plant defense signals, as well as lipids signals, weakening cell walls, attenuating feeding site function and development are still being studied in depth for several novel effectors. As direct outcome of this project, the accumulating findings will be utilized to improve our understanding of the mechanisms governing critical life-cycle phases of the parasitic M. incognita RKN, thereby facilitating design of effective controls based on perturbation of nematode behavior—without producing harmful side effects. The knowledge from this study will promote genome editing strategies aimed at developing nematode resistance in tomato and other nematode-susceptible crop species in Israel and the United States.
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