Relevant bibliographies by topics / Second level

Academic literature on the topic 'Second level'

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Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Second level"

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Cox, Sally. "Second level nurses." Nursing Standard 2, no. 19 (February 13, 1988): 36. http://dx.doi.org/10.7748/ns.2.19.36.s64.

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Betts, Lynne. "We're second level not second best." Nursing Standard 11, no. 15 (December 18, 1996): 10. http://dx.doi.org/10.7748/ns.11.15.10.s22.

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Peate, Ian. "Second-level nurse returns?" British Journal of Nursing 24, no. 22 (December 10, 2015): 1117. http://dx.doi.org/10.12968/bjon.2015.24.22.1117.

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Southsea, Sonja Gamblen. "Bring back second level nursing." Nursing Standard 12, no. 23 (February 25, 1998): 11. http://dx.doi.org/10.7748/ns.12.23.11.s28.

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Zhou, Y., Z. Chen, and K. Li. "Second-level buffer cache management." IEEE Transactions on Parallel and Distributed Systems 15, no. 6 (June 2004): 505–19. http://dx.doi.org/10.1109/tpds.2004.13.

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Janes, Jenny. "Using the term ‘second level’ implies second-best nurses." Nursing Standard 28, no. 19 (January 8, 2014): 35. http://dx.doi.org/10.7748/ns2014.01.28.19.35.s49.

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Littau, Jeremy, and Daxton R. “Chip” Stewart. "“Truthiness” and Second-Level Agenda Setting." Electronic News 9, no. 2 (April 20, 2015): 122–36. http://dx.doi.org/10.1177/1931243115581416.

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Collins, Belinda L., Will Fisher, Gary Gillette, and Robert W. Marans. "Second-Level Post-Occupancy Evaluation Analysis." Journal of the Illuminating Engineering Society 19, no. 2 (July 1990): 21–44. http://dx.doi.org/10.1080/00994480.1990.10747961.

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Valero, Alejandro, Julio Sahuquillo, Salvador Petit, Pedro Lopez, and Jose Duato. "Design of Hybrid Second-Level Caches." IEEE Transactions on Computers 64, no. 7 (July 1, 2015): 1884–97. http://dx.doi.org/10.1109/tc.2014.2346185.

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Sheaff, Marleigh. "A specialized second level trigger processor." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 263, no. 1 (January 1988): 196–98. http://dx.doi.org/10.1016/0168-9002(88)91034-0.

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Dissertations / Theses on the topic "Second level"

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Sandelin, Rikard. "Establishing DANE TLSA Deployment Levels Among Swedish Second Level Domains." Thesis, Högskolan i Skövde, Institutionen för informationsteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13730.

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Domain Based Authentication of Named Entities (DANE) is an Internet Engineering Task Force (IETF) standard released in 2012 intended to complement or in some cases replace the current Public Key Infrastructure (PKI) model. The current PKI model uses Transport Layer Security (TLS) certificates issued by Certificate Authorities (CA) binding domain names to public key. These CAs act as trust anchors during the certificate validation process. Web browsers and other TLS supported applications have large lists of trusted CA public keys. If one of these trusted CAs are compromised the whole system is compromised. DANE uses the Domain Name System (DNS) to publish TLS certificate information and create certificate associations to domain names. DANE relies on DNS Security Extensions (DNSSEC) for authentication and message integrity. Using the DNS root as a single trust anchor instead of the many CA trust anchors the attack surface is drastically reduced.In this study a quantitative survey among Swedish DNSSEC signed Second Level Domains (SLD) is performed with the aim to establish the DANE TLSA deployment level among the SLDs in Top Level Domain (TLD) .se.The results show that 686 471 of the Swedish SLDs have been DNSSEC signed which is approximately 49% of all Swedish SLDs. The number of domains that have deployed DANE is very low, with only 79 SLD found to have DANE TLSA resource records in DNS. The total number of DANE TLSA resource records were 175 and the most common service used with DANE TLSA was HTTPS on port 443 which was 62% of all DANE TLSA resource records found. The most common certificate usage field setting was three, domain issued certificates.
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Racz, Christian. "Second-Level-Domains aus kennzeichenrechtlicher Sicht /." Frankfurt am Main [u.a.] : Lang, 2002. http://www.gbv.de/dms/spk/sbb/recht/toc/336802935.pdf.

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Saka, Franklin. "Ethernet for the ATLAS second level trigger." Thesis, Royal Holloway, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395390.

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Li, Weidong. "Studies of atlas second level B-physics trigger." Thesis, Royal Holloway, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341956.

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Davey, C. "Gender & subject choice in second level education." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403189.

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RAPELLO, DEMETRIUS COSTA. "SECOND LEVEL RECOMMENDATION SYSTEM TO SUPPORT NEWS EDITING." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2012. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=22832@1.

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Sistemas de recomendação têm sido amplamente utilizados pelos grandes portais na Web, em decorrência do aumento do volume de dados disponíveis na Web. Tais sistemas são basicamente utilizados para sugerir informações relevantes para os seus usuários. Esta dissertação apresenta um sistema de recomendação de segundo nível para auxiliar equipes de jornalistas de portais de notícias no processo de recomendação de notícias relacionadas para os usuários do portal. O sistema é chamado de segundo nível pois apresenta recomendações aos jornalistas para que, por sua vez, geram recomendações aos usuários do portal. O modelo seguido pelo sistema consiste na recomendação de notícias relacionadas com base em características extraídas do próprio texto da notícia original. As características extraídas permitem a criação de consultas contra um banco de dados de notícias anteriormente publicadas. O resultado de uma consulta é uma lista de notícias candidatas à recomendação, ordenada pela similaridade com a notícia original e pela data de publicação, que o editor da notícia original manualmente processa para gerar a lista final de notícias relacionadas.
Recommendation systems are widely used by major Web portals due to the increase in the volume of data available on the Web. Such systems are basically used to suggest information relevant to their users. This dissertation presents a second-level recommendation system, which aims at assisting the team of journalists of a news Web portal in the process of recommending related news for the users of the Web portal. The system is called second level since it creates recommendations to the journalists Who, in turn, generate recommendations to the users. The system follows a model based on features extracted from the text itself. The extracted features permit creating queries against a news database. The query result is a list of candidate news, sorted by score and date of publication, which the news editor manually processes to generate the final list of related news.
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De, la Cruz Megan J. Abedi-Djourabtchi Amir. "Second-order characteristics of multi-level elections in Spain /." Online version, 2010. http://content.wwu.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=354&CISOBOX=1&REC=1.

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O'Higgins-Norman, James. "Exploring homophobia and homophobic bullying in Irish second-level schools." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/10020511/.

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Kruuse, Helen. "Substantive second-level reasoning and experiential learning in legal ethics." Juta Law Publishing, 2012. http://hdl.handle.net/10962/68983.

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This article takes a critical look at law teaching in South Africa and seeks to consider how the application of experiential learning theory may assist law students in gaining a deeper understanding of the law in general, and the complexities of real life practice in particular. While clinical legal education is often seen as the locus of experiential learning in law, the author proposes that well-structured simulations in class can achieve similar goals. The article comprises a description of the nature of experiential learning and a further description of the application of the principles of experiential learning in a particular simulation exercise in a Legal Ethics course (using the US case of Wash St Phys Ins Exch v Fisons Corp 858 P2d 1054 (Wash 1993) as a basis). The author posits that the so-called experiential learning "cycle" or "process" enables a process of learning which draws out the students' beliefs and ideas about a topic so that it can be examined, tested and integrated with new, more refined ideas. This notion is then in keeping with the expectation that students who emerge from higher education institutions have developed meta-cognitive skills. Essentially then, it is hoped that, by using the methods proposed in this article, students can then manage their own development and learning throughout life.
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Vie, Jean-Léopold. "Second-order derivatives for shape optimization with a level-set method." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC1072/document.

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Le but de cette thèse est de définir une méthode d'optimisation de formes qui conjugue l'utilisation de la dérivée seconde de forme et la méthode des lignes de niveaux pour la représentation d'une forme.On considèrera d'abord deux cas plus simples : un cas d'optimisation paramétrique et un cas d'optimisation discrète.Ce travail est divisé en quatre parties.La première contient le matériel nécessaire à la compréhension de l'ensemble de la thèse.Le premier chapitre rappelle des résultats généraux d'optimisation, et notamment le fait que les méthodes d'ordre deux ont une convergence quadratique sous certaines hypothèses.Le deuxième chapitre répertorie différentes modélisations pour l'optimisation de formes, et le troisième se concentre sur l'optimisation paramétrique puis l'optimisation géométrique.Les quatrième et cinquième chapitres introduisent respectivement la méthode des lignes de niveaux (level-set) et la méthode des éléments-finis.La deuxième partie commence par les chapitres 6 et 7 qui détaillent des calculs de dérivée seconde dans le cas de l'optimisation paramétrique puis géométrique.Ces chapitres précisent aussi la structure et certaines propriétés de la dérivée seconde de forme.Le huitième chapitre traite du cas de l'optimisation discrète.Dans le neuvième chapitre on introduit différentes méthodes pour un calcul approché de la dérivée seconde, puis on définit un algorithme de second ordre dans un cadre général.Cela donne la possibilité de faire quelques premières simulations numériques dans le cas de l'optimisation paramétrique (Chapitre 6) et dans le cas de l'optimisation discrète (Chapitre 7).La troisième partie est consacrée à l'optimisation géométrique.Le dixième chapitre définit une nouvelle notion de dérivée de forme qui prend en compte le fait que l'évolution des formes par la méthode des lignes de niveaux, grâce à la résolution d'une équation eikonale, se fait toujours selon la normale.Cela permet de définir aussi une méthode d'ordre deux pour l'optimisation.Le onzième chapitre détaille l'approximation d'intégrales de surface et le douzième chapitre est consacré à des exemples numériques.La dernière partie concerne l'analyse numérique d'algorithmes d'optimisation de formes par la méthode des lignes de niveaux.Le Chapitre 13 détaille la version discrète d'un algorithme d'optimisation de formes.Le Chapitre 14 analyse les schémas numériques relatifs à la méthodes des lignes de niveaux.Enfin le dernier chapitre fait l'analyse numérique complète d'un exemple d'optimisation de formes en dimension un, avec une étude des vitesses de convergence
The main purpose of this thesis is the definition of a shape optimization method which combines second-order differentiationwith the representation of a shape by a level-set function. A second-order method is first designed for simple shape optimization problems : a thickness parametrization and a discrete optimization problem. This work is divided in four parts.The first one is bibliographical and contains different necessary backgrounds for the rest of the work. Chapter 1 presents the classical results for general optimization and notably the quadratic rate of convergence of second-order methods in well-suited cases. Chapter 2 is a review of the different modelings for shape optimization while Chapter 3 details two particular modelings : the thickness parametrization and the geometric modeling. The level-set method is presented in Chapter 4 and Chapter 5 recalls the basics of the finite element method.The second part opens with Chapter 6 and Chapter 7 which detail the calculation of second-order derivatives for the thickness parametrization and the geometric shape modeling. These chapters also focus on the particular structures of the second-order derivative. Then Chapter 8 is concerned with the computation of discrete derivatives for shape optimization. Finally Chapter 9 deals with different methods for approximating a second-order derivative and the definition of a second-order algorithm in a general modeling. It is also the occasion to make a few numerical experiments for the thickness (defined in Chapter 6) and the discrete (defined in Chapter 8) modelings.Then, the third part is devoted to the geometric modeling for shape optimization. It starts with the definition of a new framework for shape differentiation in Chapter 10 and a resulting second-order method. This new framework for shape derivatives deals with normal evolutions of a shape given by an eikonal equation like in the level-set method. Chapter 11 is dedicated to the numerical computation of shape derivatives and Chapter 12 contains different numerical experiments.Finally the last part of this work is about the numerical analysis of shape optimization algorithms based on the level-set method. Chapter 13 is concerned with a complete discretization of a shape optimization algorithm. Chapter 14 then analyses the numerical schemes for the level-set method, and the numerical error they may introduce. Finally Chapter 15 details completely a one-dimensional shape optimization example, with an error analysis on the rates of convergence
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Books on the topic "Second level"

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Richard, Wynne. Second-level teachers working hours. Dublin: Association of Secondary Teachers, Ireland, 1992.

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Digital techniques: Second-third level. London: Hutchinson, 1985.

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Archer, Anita L. Phonics for reading: Second level. North Billerica, Mass: Curriculum Associates, 1991.

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Kearns, Una M. Job stress in second level teaching. Dublin: University College Dublin, 1996.

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Waldron, John. Study skills for second level students. Dublin: School and College Publishing, 1995.

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Open University. [A216 Course Team]. A216 Arts: A second level course. Milton Keynes: Open University, 1999.

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Second-Level-Domains aus kennzeichenrechtlicher Sicht. Frankfurt am Main: P. Lang, 2002.

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Ireland. Office of the Comptroller and Auditor General. Planning of second level school accommodation. Dublin: Stationery Office, 1996.

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Safe at second. New York: Philomel Books, 1999.

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Autocad 2012 tutorial: Second level: 3d modeling. Mission, Kan: SDC, 2011.

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Book chapters on the topic "Second level"

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Gianesini, Sergio, Paolo Zamboni, and Erika Mendoza. "Second-Level Imaging." In Saphenous Vein-Sparing Strategies in Chronic Venous Disease, 115–18. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70638-2_5.

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Weik, Martin H. "second-level message." In Computer Science and Communications Dictionary, 1532. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_16770.

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Weik, Martin H. "second-level storage." In Computer Science and Communications Dictionary, 1532. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_16772.

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Dimitriu, Dan G. "Second Level (S)." In A, B, See… in 3D, 52–83. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-031-79369-1_3.

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Gurjar, Nikhil. "Second Level Review-I." In Lecture Notes in Management and Industrial Engineering, 103–28. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0782-8_7.

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Gurjar, Nikhil. "Second Level Review-II." In Lecture Notes in Management and Industrial Engineering, 129–44. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0782-8_8.

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Gurjar, Nikhil. "Second Level Review-III." In Lecture Notes in Management and Industrial Engineering, 145–57. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0782-8_9.

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Weik, Martin H. "second-level message display." In Computer Science and Communications Dictionary, 1532. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_16771.

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Cardinali, Daniel Pedro. "Second Level: The Brainstem." In Autonomic Nervous System, 113–73. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-57571-1_4.

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Santoso, Anisa. "The other second-level game." In Migrant Workers and ASEAN, 152–85. New York : Routledge, 2017.: Routledge, 2017. http://dx.doi.org/10.4324/9781315512457-6.

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Conference papers on the topic "Second level"

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Quille, Keith, Roisin Faherty, Susan Bergin, and Brett A. Becker. "Second Level Computer Science." In Koli Calling '18: 18th Koli Calling International Conference on Computing Education Research. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3279720.3279742.

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Hansen, John Renner. "The ATLAS Second Level Trigger." In Proceedings of the International Conference. WORLD SCIENTIFIC, 1996. http://dx.doi.org/10.1142/9789814447188_0082.

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Zhuo Han and Kumpati S. Narendra. "Second level adaptation using multiple models." In 2011 American Control Conference. IEEE, 2011. http://dx.doi.org/10.1109/acc.2011.5991086.

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Harvey, W., D. Kalp, M. Tambe, D. McKeown, and A. Newell. "The effectiveness of task-level parallelism for high-level vision." In the second ACM SIGPLAN symposium. New York, New York, USA: ACM Press, 1990. http://dx.doi.org/10.1145/99163.99181.

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Huang, Huang. "Second level adaption of the characteristic modeling." In 2015 IEEE International Conference on Information and Automation (ICIA). IEEE, 2015. http://dx.doi.org/10.1109/icinfa.2015.7279586.

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Ning, J. Q., and M. T. Harandi. "Automating the function-level understanding of programs." In the second international conference. New York, New York, USA: ACM Press, 1989. http://dx.doi.org/10.1145/67312.67326.

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Ye, Yang, Ming Zhou, and Chin-Yew Lin. "Sentence level machine translation evaluation as a ranking problem." In the Second Workshop. Morristown, NJ, USA: Association for Computational Linguistics, 2007. http://dx.doi.org/10.3115/1626355.1626391.

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Uijterwaal, H. A. J. R., A. Quadt, S. Topp-Jorgensen, and R. C. E. Devenish. "The ZEUS Central Tracking Detector Second Level Trigger." In Proceedings of the International Conference. WORLD SCIENTIFIC, 1996. http://dx.doi.org/10.1142/9789814447188_0084.

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Ma, Bo, Yuwei Wu, and Pei Li. "Level set segmentation using image second order statistics." In Seventh International Symposium on Multispectral Image Processing and Pattern Recognition (MIPPR2011), edited by Tianxu Zhang and Nong Sang. SPIE, 2011. http://dx.doi.org/10.1117/12.902005.

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McElvaney, O. J., B. D. Hobbs, M. Murphy, O. F. McElvaney, C. Gunaratnam, E. P. Reeves, and N. G. McElvaney. "Attitudes of Irish Second-Level Students Towards Vaping." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1080.

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Reports on the topic "Second level"

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Levine, J., and P. Hoffman. Variants in Second-Level Names Registered in Top-Level Domains. RFC Editor, May 2013. http://dx.doi.org/10.17487/rfc6927.

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Leiba, B. Registration of Second-Level URN Namespaces under "ietf". RFC Editor, April 2013. http://dx.doi.org/10.17487/rfc6924.

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Mohan, Gretta, Selina McCoy, Eamonn Carroll, Georgiana Mihut, Seán Lyons, and Ciarán Mac Domhnaill. Learning for all? Second-level education in Ireland during COVID-19. ESRI, June 2020. http://dx.doi.org/10.26504/sustat92.pdf.

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Pan, Wei, A. Serafin, J. S. Xia, Y. Liang, N. S. Sullivan, K. W. Baldwin, K. W. West, L. N. Pfeiffer, and D. C. Tsui. Competing Quantum Hall Phases in the Second Landau Level in Low Density Limit. Office of Scientific and Technical Information (OSTI), January 2015. http://dx.doi.org/10.2172/1177382.

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Peters, T. J., and W. R. Park. Evaluation of methods to measure surface level in waste storage tanks: Second test sequence. Office of Scientific and Technical Information (OSTI), September 1993. http://dx.doi.org/10.2172/10187115.

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McCoy, Selina, and Georgiana Mihut. Examining the experiences of students, teachers and leaders at Educate Together second-level schools. ESRI, October 2020. http://dx.doi.org/10.26504/rs113.

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Huang, Z. Generation of GW-Level, Sub-Angstrom Radiation in the LCLS Using a Second-Harmonic Radiator. Office of Scientific and Technical Information (OSTI), September 2004. http://dx.doi.org/10.2172/833034.

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Finley, James C., Susan L. Stout, Timothy G. Pierson, and Barbara J. McGuinness. Managing timber to promote sustainable forests: a second-level course for the Sustainable Forestry Initiative of Pennsylvania. Newtown Square, PA: U.S. Department of Agriculture, Forest Service, Northern Research Station, 2007. http://dx.doi.org/10.2737/nrs-gtr-11.

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Kern, Kristen. Developing a test of communicative competence for English as a second language students at the college level. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.694.

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Splitter, Gary A., Menachem Banai, and Jerome S. Harms. Brucella second messenger coordinates stages of infection. United States Department of Agriculture, January 2011. http://dx.doi.org/10.32747/2011.7699864.bard.

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Aim 1: To determine levels of this second messenger in: a) B. melitensiscyclic-dimericguanosinemonophosphate-regulating mutants (BMEI1448, BMEI1453, and BMEI1520), and b) B. melitensis16M (wild type) and mutant infections of macrophages and immune competent mice. (US lab primary) Aim 2: To determine proteomic differences between Brucelladeletion mutants BMEI1453 (high cyclic-dimericguanosinemonophosphate, chronic persistent state) and BMEI1520 (low cyclicdimericguanosinemonophosphate, acute virulent state) compared to wild type B. melitensisto identify the role of this second messenger in establishing the two polar states of brucellosis. (US lab primary with synergistic assistance from the Israel lab Aim 3: Determine the level of Brucellacyclic-dimericguanosinemonophosphate and transcriptional expression from naturally infected placenta. (Israel lab primary with synergistic assistance from the US lab). B. Background Brucellaspecies are Gram-negative, facultative intracellular bacterial pathogens that cause brucellosis, the most prevalent zoonosis worldwide. Brucellosis is characterized by increased abortion, weak offspring, and decreased milk production in animals. Humans are infected with Brucellaby consuming contaminated milk products or via inhalation of aerosolized bacteria from occupational hazards. Chronic human infections can result in complications such as liver damage, orchitis, endocarditis, and arthritis. Brucellaspp. have the ability to infect both professional and non-professional phagocytes. Because of this, Brucellaencounter varied environments both throughout the body and within a cell and must adapt accordingly. To date, few virulence factors have been identified in B. melitensisand even less is known about how these virulence factors are regulated. Subsequently, little is known about how Brucellaadapt to its rapidly changing environments, and how it alternates between acute and chronic virulence. Our studies suggest that decreased concentrations of cyclic dimericguanosinemonophosphate (c-di-GMP) lead to an acute virulent state and increased concentrations of c-di-GMP lead to persistent, chronic state of B. melitensisin a mouse model of infection. We hypothesize that B. melitensisuses c-di-GMP to transition from the chronic state of an infected host to the acute, virulent stage of infection in the placenta where the bacteria prepare to infect a new host. Studies on environmental pathogens such as Vibrio choleraeand Pseudomonas aeruginosasupport a mechanism where changes in c-di-GMP levels cause the bacterium to alternate between virulent and chronic states. Little work exists on understanding the role of c-di-GMP in dangerous intracellular pathogens, like Brucellathat is a frequent pathogen in Israeli domestic animals and U.S. elk and bison. Brucellamust carefully regulate virulence factors during infection of a host to ensure proper expression at appropriate times in response to host cues. Recently, the novel secondary signaling molecule c-di-GMP has been identified as a major component of bacterial regulation and we have identified c-di-GMP as an important signaling factor in B. melitensishost adaptation. C. Major conclusions, solutions, achievements 1. The B. melitensis1453 deletion mutant has increased c-di-GMP, while the 1520 deletion mutant has decreased c-di-GMP. 2. Both mutants grow similarly in in vitro cultures; however, the 1453 mutant has a microcolony phenotype both in vitro and in vivo 3. The 1453 mutant has increased crystal violet staining suggesting biofilm formation. 4. Scanning electron microscopy revealed an abnormal coccus appearance with in increased cell area. 5. Proteomic analysis revealed the 1453 mutant possessed increased production of proteins involved in cell wall processes, cell division, and the Type IV secretion system, and a decrease in proteins involved in amino acid transport/metabolism, carbohydrate metabolism, fatty acid production, and iron acquisition suggesting less preparedness for intracellular survival. 6. RNAseq analysis of bone marrow derived macrophages infected with the mutants revealed the host immune response is greatly reduced with the 1453 mutant infection. These findings support that microlocalization of proteins involved in c-di-GMP homeostasis serve a second messenger to B. melitensisregulating functions of the bacteria during infection of the host.
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