Dissertations / Theses on the topic 'SEC Regulations'
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Palma, Kelly. "Hedge funds and the SEC regulation of Hedge Fund Advisers : /." Staten Island, N.Y. : [s.n.], 2006. http://library.wagner.edu/theses/business/2006/thesis_bus_2006_palma_hedge.pdf.
Full textFaribault, Christian. "Should Ontario adopt a regulation similar to the SEC Regulation FD to counter selective disclosure?" Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63301.pdf.
Full textLiu, Zhenfeng. "The Effect of Shortened Reporting Lag on the Usefulness of Form 20-F." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2530.
Full textKadri, Sabah. "miRNA Regulation in Development." Research Showcase @ CMU, 2012. http://repository.cmu.edu/dissertations/186.
Full textKashani, Hossein. "Government intervention and efficiency in the North Sea petroleum industry." Thesis, University of Surrey, 2000. http://epubs.surrey.ac.uk/804404/.
Full textHochscheid, Sandra. "Thermoregulation, metabolism and buoyancy regulation in sea turtles." Thesis, University of Aberdeen, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288349.
Full textRuss, Robert W. "SEC Regulation of Corporate 10K Filing Dates: The Effect on Earnings Management and Market Recognition." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/721.
Full textGong, Zhiyuan. "Regulation of tubulin gene expression in sea urchin embryos." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74267.
Full textAkun, Deniz <1982>. "Banking Regulation in Turkey and Russia: An Economic Analysis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5328/.
Full textPapp, Laura V., and n/a. "Multiple Levels of Regulation of Human SECIS Binding Protein 2, SBP2." Griffith University. School of Biomolecular and Biomedical Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070208.145623.
Full textLimardi, Michela <1981>. "Trade policy, government and non-State regulation of international labor and environmental standards." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/4205/.
Full textSun, Zhongling. "Signal-Dependent Regulation of Skeletogenesis in the Sea Urchin Embryo." Research Showcase @ CMU, 2016. http://repository.cmu.edu/dissertations/687.
Full textLarman, Mark Graham. "Calcium and MAP kinase regulation during the cell cycle." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340683.
Full textSyukri, Ahmad. "Regulation and accumulation of metals in selected temperate and tropical anthozoans." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294523.
Full textSu, Yi-Hsien. "The regulation of sea urchin sperm by cyclic nucleotides and calcium /." Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3191992.
Full textBroman, Evelina. "Regulation of bacterial production in the Råne estuary, northern Baltic Sea." Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-108240.
Full textHanke, Philip Cosmo <1983>. "Regulating State Aid: Inter-jurisdictional competition, public choice, and corporate governance." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6692/.
Full textLindberg, Marcus, Per Johansson, and Mikael Joélius. "LNG - Framtidens fartygsbränsle : Vad är det som hämmar utvecklingen av LNG-drift i Sverige?" Thesis, Linnéuniversitetet, Sjöfartshögskolan (SJÖ), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-39743.
Full textShipping today faces stricter environmental requirements for pollution from vessels. Shipping companies have started to look for alternative fuel to achieve better environmental outcome. The Baltic Sea today is a major trading area for shipping . On 1 of January 2015 a new set of brand new and stricter regulation is getting implemented and these regulations are called SECA. Vessel running on LNG as an alternative fuel is today discussed extensively within the Swedish Maritime forum where emissions of NOx, sulfur and particles are less recipients than in heavy fuel oil (HFO). One of todays problems with a LNG distribution in Sweden are that the infrastructure is incomplete and outdated. This report has been built upon qualitative interviews with important actors within the Swedish maritime forum and also what impedes the development of the LNG’s infrastructure. The outcome of the interviews showed that the development has been slowed down because none within the Swedish martime forum have dared to take the first step. The ports does not want to develop terminals when there is no market demand and the shipping companies does not want to build vessel that runs on LNG when there is no market for distribution. Swedish governments involvement has been very weak, almost non-existing. There are also gaps in the Swedish regulations and restrictions of LNG cargo handling. This is aslo one of the factors that the development of LNG has been impeded.
Summerhill, Robin James. "The sea urchin egg ryanodine receptor and its regulation by cyclic ADP-ribose." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300145.
Full textKrsmanovic, Dusko <1985>. "A Law and Economics Analysis of Lobbying Regulation Towards an optimal structure through the Cost Indicator Index." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6695/.
Full textNovak, Zsofia A. "The role and regulation of Asterless in the centrosome cycle." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4fadaef1-8c9e-4c70-ac59-47f35af3988e.
Full textOrcutt, K. M. "Environmental factors regulating N2 fixation by Trichodesmium spp. in the Sargasso Sea." Thesis, Swansea University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638373.
Full textDyer, Alexei. "Acid-base regulation in the sea urchin Parechinus angulosus during CO₂-induced seawater acidification." Bachelor's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/7631.
Full textDesogus, Claudia <1980>. "Competition and Innovation in the EU Regulation of Pharmaceuticals: The Case of Parallel Trade." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/3116/.
Full textLoftus, Sarah Jane. "Regulation of E2F-1 by methylation and NEDDylation." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e0befc5a-76a3-4a35-b768-80a9dda6f307.
Full textLehmkuhl-Dakhwe, K. Virginia. "Regulation of p53, p21, ARF, BIM, and BAX by the Transcription Factor Trip-Br1." Ohio University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1194549826.
Full textHerriott, Ashleigh Jane. "Regulation of spindle assembly checkpoint (SAC) by phosphorylation and protein-protein interactions in Drosophila melanogaster." Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1736.
Full textLobo, Ana Karla Moreira. "Photosynthesis regulation by sucrose metabolism under water deficit and source-sink alterations in sugarcane." reponame:Repositório Institucional da UFC, 2016. http://www.repositorio.ufc.br/handle/riufc/21479.
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Water deficit stress is the major limiting factor for plant growth and development, constraining food production. In order to survive in such dry conditions, many biochemical and physiological changes must be triggered by plants. In general, the responses to drought are loss of water content, reductions of stomatal conductance and photosynthesis and increase of carbohydrates. Soluble sugars play a key role in plant metabolism, acting as substrates and modulators of enzyme activity in carbon-related pathways and controlling the expression of different genes related to carbon, lipid and nitrogen routs. However, the mechanisms involved with photosynthesis down-regulation by drought and sugars in C4 plants are not fully understood. The aim of this study was to investigate how drought and source-sink perturbation regulate photosynthesis in sugarcane plants. Therefore, two studies were conducted with sugarcane plants with four months old cultivated under greenhouse conditions. In the first study sugarcane plants (cv. IACSP94-2094) were subjected to water deficit for 5 days (WD) with concomitant spraying of 50 mM exogenous sucrose (WD + Suc). While in the second study source-sink relationship was perturbed in two sugarcane cultivars (cv. IACSP94-2094 and cv. IACSP95-5000) by imposing partial darkness, spraying 50 mM exogenous sucrose and their combination for 5 days. The negative effects of WD in the gas exchange and photochemical parameters were aggravated by exogenous sucrose. Photosynthesis reductions were related to both stomatal and biochemical limitations, but exogenous sucrose intensified metabolic restrictions mainly through down-regulation of Rubisco initial activity and PSII effective quantum efficiency in drought-stressed plants. In addition, Rubisco activation state was decreased by WD + Suc, indicating perhaps that the activity of this enzyme was reduced by tight-binding inhibitors, such as sugars phosphates. Sucrose metabolism enzymes and sugars amount were also differently altered by WD and WD + Suc in leaves, sheath and stalk in WD and WD +Suc plants. Interestingly, Sucrose/hexose ratio decreased in both leaf and sheath whereas it was increased in stalk, suggesting that sucrose and related sugars were intensely metabolized and transported in drought-stressed plants. In well-watered conditions, photosynthesis was inhibited by sucrose spraying in both genotypes, through decreases in maximum Rubisco carboxylation rate (Vcmax), initial slope of A-Ci curve (k), stomatal conductance (gs) and ATP production driven by electron transport (Jatp). The partial darkness and sucrose spraying combination did not change photosynthesis in both genotypes. Significant increases in Vcmax, gs and Jatp and marginal increases in k were noticed when combining partial darkness and sucrose spraying compared with sucrose spraying alone. Altogether, these results suggest that CO2 assimilation impairment is aggravated by exogenous sucrose in drought-stressed plants. This limitation was mainly related to biochemical restrictions, specially associated with Rubisco initial activity and PSII quantum efficiency. In contrast, in vitro PEPCase activity and amount were increased in sucrose-treated plants, suggesting that C4 cycle efficiency was reduced in vivo by C3 cycle inhibition under drought conditions. Moreover, sucrose amount was increased in the stalk, suggesting the feedback regulation from stalk to source leaves in drought-stressed plants. Our data also revealed that increases in sink strength due to partial darkness offset the inhibition of sugarcane photosynthesis caused by sucrose spraying, enhancing the knowledge on endogenous regulation of sugarcane photosynthesis through the source-sink relationship.
A deficiência hídrica é o principal fator limitante para o crescimento e desenvolvimento das culturas. Para sobreviver nessas condições adversas, várias modificações bioquímicas e fisiológicas são desencadeadas pelas plantas. Em geral, os efeitos da seca em plantas são diminuição do status hídrico, reduções da condutância estomática, fotossíntese e crescimentos e aumentos nos níveis de carboidratos. Os açúcares solúveis desempenham papéis chave no metabolismo das plantas, atuando como substratos e moduladores da atividade enzimática em vias relacionadas com o carbono. Além disso, os açúcares controlam a expressão de genes associados com as rotas do metabolismo do carbono, lipídios e nitrogênio. Entretanto, os mecanismos envolvidos com a regulação negativa da fotossíntese por deficiência hídrica e açúcares em plantas C4 não estão totalmente entendidos. O objetivo deste estudo foi investigar como a deficiência hídrica e perturbações na relação fonte-dreno regulam a fotossíntese em plantas de cana-de-açúcar. Dois estudos foram conduzidos com plantas de cana-de-açúcar com quatro meses de idade cultivadas sob condições de casa de vegetação. No primeiro estudo, plantas de cana-de-açúcar (cv. IACSP94-2094) foram submetidas a deficiência hídrica por 5 dias (WD) com subsequente aplicação de sacarose exógena 50 mM (WD + Suc). Enquanto que no segundo estudo a relação fonte-dreno foi perturbada em duas cultivares de cana-de-açúcar (cv. IACSP94-2094 and cv. IACSP95-5000) pela imposição parcial de sombreamento, aplicação de sacarose exógena 50 mM e por suas combinações por 5 dias. Os efeitos negativos de WD nos parâmetros de trocas gasosas e fotoquímicos foram agravados por sacarose exógena. As reduções na fotossíntese foram relacionadas com limitações estomáticas e bioquímicas, porém a sacarose exógena intensificou as restrições bioquímicas principalmente por reduções na atividade inicial de Rubisco e eficiência quântica do PSII em plantas sob seca. Além disso, o estado de ativação de Rubisco foi inibido por WD + Suc, sugerindo que a atividade inicial dessa enzima foi possivelmente reduzida por inibidores que se ligam fortemente em seu sitio ativo, tais como açúcares fosfato. As enzimas do metabolismo de sacarose e a concentração de açúcares foram modificados diferentemente por WD e WD + Suc em folhas, bainha e colmo. Interessantemente, a relação sacarose/hexose decresceu em folhas e bainha, enquanto que no colmo essa relação aumentou, sugerindo que sacarose e outros açúcares relacionados foram intensamente metabolizados e transportados. Em condições irrigadas a fotossíntese foi inibida pela aplicação de sacarose nos dois genótipos, através de decréscimos da taxa máxima de carboxilação de Rubisco (Vcmax), inclinação inicial da curva A-Ci (k), condutância estomática (gs) e produção de ATP direcionada pelo transporte de elétrons (Jatp). A combinação de sombreamento parcial e sacarose não alterou a fotossíntese em ambos os genótipos. Significantes aumentos em Vcmax, gs, Jatp e k foram observados quando sombreamento parcial e sacarose foram combinados em comparação com plantas tratadas apenas com sacarose. Em conclusão, esses resultados sugerem que o impedimento da assimilação de CO2 é agravada por adição de sacarose exógena em plantas sob estresse hídrico. Essa limitação foi relacionada principalmente com restrições bioquímicas, especialmente associadas com reduções na atividade inicial de Rubisco e eficiência quântica do FSII. Em contraste, a atividade in vivo e concentração de PEPCase foram aumentadas em plantas tratadas com sacarose e estresse hídrico, sugerindo que a eficiência do ciclo C4 foi reduzida in vivo por inibições do ciclo C3 sob condições de seca. Além disso, o conteúdo de sacarose aumentou no colmo, indicando uma regulação de feedback do colmo para as folhas em plantas sob seca. Nossos dados revelam ainda que aumentos na força do dreno devido ao sombreamento parcial aliviaram os efeitos inibitórios na fotossíntese de cana-de-açúcar causados pela aplicação de sacarose, aumentando o conhecimento na regulação endógena da fotossíntese de cana-de-açúcar através da relação fonte-dreno.
Medina, Henríquez Paula Javiera. "Retinoic acid signaling pathway : gene regulation during the onset of puberty in the European sea bass." Doctoral thesis, Universitat Politècnica de Catalunya, 2019. http://hdl.handle.net/10803/667249.
Full textLa acuicultura de la lubina Europea (Dicentrarchus labrax) es una industria pujante en España que alcanza unas 23.500 t y un valor de mercado cercano a 133 millones de euros. Sin embargo, la mayoría de las piscifactorías produce un elevado porcentaje de machos (70-90%) ya que, para acelerar el desarrollo y el crecimiento, se aumentan las temperaturas de cultivo durante las primeras etapas de vida. Esto supone un problema en la lubina ya que generalmente las hembras presentan mayores tasas de crecimiento que los machos y que el 30% de estos alcanza la pubertad precozmente durante el primer año de vida, antes de llegar a la talla comercial. Además, la pubertad está acompañada por una disminución de las tasas de crecimiento somático que implica un desgaste muscular y pérdidas en la calidad organoléptica de la carne. Debido a estas respuestas biológicas, existe una gran necesidad de comprender el proceso reproductivo y su control en condiciones intensivas de producción. El objetivo general de esta tesis es contribuir al conocimiento de la reproducción de la lubina europea, y se centra en el estudio de la ruta de señalización del ácido retinoico (RA) durante estados tempranos del desarrollo y la maduración sexual. La utilización de un oligomicroarray de lubina, indicó la existencia de varios genes con expresión diferencial al inicio de la pubertad en machos. Entre ellos seleccionamos un grupo que incluía genes de la vía de señalización del RA, la forma activa de la vitamina A, fundamental para el inicio de la meiosis en tetrápodos. Un análisis in silico nos permitió describir por primera vez, la estructura, filogenia y la historia evolutiva de genes y proteínas implicados en la síntesis y degradación del RA. Tras un exhaustivo estudio histológico del desarrollo gonadal pudimos identificar con exactitud estados específicos de la diferenciación ovárica y testicular. El estudio de la expresión de los principales genes de la ruta de señalización del RA en estados específicos del desarrollo gonadal sirvió para demostrar su papel en el inicio de la pubertad. Finalmente, se puso a punto un sistema de cultivo in vitro de explantes testiculares de individuos prepúberes tanto juveniles como adultos para el estudio funcional y la determinación del papel de la ruta de señalización del RA en el inicio de la pubertad en machos. Con este fin se evaluó la respuesta funcional de los genes relacionados con el transporte, síntesis, degradación y señalización del RA ante la presencia de estimuladores e inhibidores de la vía y en diferentes escenarios de meiosis. Los resultados de la tesis demuestran que en la lubina: a) el inicio de la meiosis coincide con un aumento en los niveles de 11KT y que involucra varias rutas, entre ellas la de señalización del RA; b) las enzimas relacionadas con la síntesis y degradación del RA poseen todas las características estructurales para poder cumplir su función; c) existe una historia evolutiva bien conservada de las enzimas implicadas en la síntesis y degradación del RA, d) al igual que en otros teleósteos, la ausencia de stra8, marcador específico de meiosis en tetrápodos, sugiere que la señalización del RA en esta especie no ocurre a través de la transducción de este gen en particular; e) los genes implicados en la vía de señalización del RA están conservados, igual que en otros vertebrados, y juegan un papel relevante en el desarrollo gonadal y la gametogénesis, f) la dinámica de expresión del gen cyp26a1 durante el desarrollo gonadal le convierte en un excelente marcador molecular del inicio de la meiosis. Esta tesis contribuye al conocimiento del inicio de la pubertad en la lubina al caracterizar por primera vez la ruta de señalización del RA en esta especie y al proponer herramientas moleculares para su estudio. Además, aporta nuevas preguntas y abre una importante línea de investigación para el estudio del RA en la pubertad
Rößl, Dietmar, and Elisabeth Reiner. "The Implementation of the Regulation 1435/2003 on the Statute European Cooperative Society (SCE) in Europe." WU Vienna University of Economics and Business, 2010. http://epub.wu.ac.at/2937/1/SCE_Report_Austria%2Dfinal.pdf.
Full textKlambauer, Eva. "Sex work regulation and legal consciousness : a comparative socio-legal study of England (UK) and New South Wales (Australia)." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/sex-work-regulation-and-legal-consciousness(19913efc-81d7-4515-88d2-e4cb34875ef1).html.
Full textRogers, David. "CIS-REGULATORY ANALYSIS OF THE PIGMENT CELL DIFFERENTIATION GENE POLYKETIDE SYNTHASE." Master's thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2701.
Full textM.S.
Department of Biology
Sciences
Biology MS
Unsworth, Amanda J. "The role of protein kinase C in platelet activation." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:114582b8-185a-41f5-958c-77038fb185df.
Full textRiedemann, Johann. "Functional analysis and recombinant expression of a sea urchin G-string binding factor." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52277.
Full textThesis (MSc)--Stellenbosch University, 2001.
ENGLISH ABSTRACT: The sea urchin G-string binding factor 1 (suGF1) has previously been shown to bind with high affinity and selectivity to stretches of contiguous deoxyguanosine residues, a DNA motif found in the upstream regions of many unrelated genes from several organisms. It has been proposed that suGF1 plays a role in transcriptional regulation. Homopurine.homopyrimidine stretches have been shown to form unusual DNA structures, in vitro. To investigate the potential of the suGF1 binding site to form unusual structures under certain conditions, synthetic oligodeoxyribonucleotides containing the suGF1 poly(dG).(dC) binding site were subjected to circular dichroism (CD) analyses. The CD results indicate that the suGF1 binding site forms a mixture of unusual DNA structures, as deduced by comparison with the spectra obtained for B-DNA, triplex and quadruplex conformations. These results are consistent with the hypothesis that suGF1 specifically recognises G-strings that exhibit unusual structures. Exhaustive database searches showed that suGF1 has no significant homology with any previously identified proteins or cDNAs from any species. Given the relevance of mammalian models to medical science, and since no sea urchin cell lines are currently available, the identification of a mammalian functional homologue would facilitate determination of the in vivo function of such a potentially important, putative, novel DNAbinding protein in mammalian cell lines. In this study sequence analysis tools were used to identify hORFX, a putative human functional homologue of suGF1. Similarities in the domain organisation of the two proteins, prompted an investigation into the DNA-binding properties of hORFX, as well as a more detailed structure prediction analysis, with a view to determining whether hORFX is a functional homologue of suGF1. hORFX was successfully expressed in vitro, but lacked the ability to specifically bind G-strings. Theoretical predictions suggest that suGF1 has a DNA-binding domain belonging to a different family to that predicted for hORFX, consistent with differences in their respective DNA-binding specificities. suGF1 and hORFX were predicted to have helix-turn-helix and helix-loop-helix DNA-binding domains, respectively. Taken together the results do not support the hypothesis that hORFX is a suGF1 homologue. To date, no direct evidence for the in vivo function of suGF1 has been obtained. With a view to performing transactivation assays in the future, the expression of suGF1 in yeast was investigated in this project. An suGF1 expression construct was engineered and transformed into a protease-deficient yeast strain. Nuclear extracts were prepared and subjected to SOS-PAGE and electrophoretic mobility shift assays (EMSAs). suGF1 was shown to be successfully expressed in yeast cells and exhibited similar G-string-binding properties to that of native and in vitro transcribed and translated (IVT) suGF1. The suGF1 eDNA was also subjected to in si/ico expression, which together with the SDSPAGE results of yeast nuclear extracts and IVT suGF1, indicated that the protein might be expressed as multiple truncated products, due to the utilisation of multiple AUG translation start sites. These in vitro results are crucial for the ultimate outcome and correct interpretation of future transactivation experiments and lay the foundation for further investigation into the possible role of suGF1 in transcriptional regulation.
AFRIKAANSE OPSOMMING: In die verlede is bewys dat die seepampoentjie G-string-bindende faktor (suGF1) hoë affiniteit en spesifisiteit vir aaneenlopende volgordes van deoksiguanosien residue besit. Hierdie DNA motief kom algemeen voor in die stroom-op gebiede van verskeie gene in verskillende organismes. Daar is 'n veronderstelling dat suGF1 betrokke is by die regulering van geenuitdrukking. Vroeër is bewys dat homopurien.homopirimidien-ryke areas die vermoë besit om in vitro ongewone DNA-strukture te vorm. Die potentiaal van die suGF1-bindingsetel om ongewone DNA-strukture te vorm is gevolglik deur sirkulêre dikroïsme (SD) analise ondersoek. Vergelyking van die spektra vir B-DNA-, tripleks- en kwadrupleks-strukture met dié van die suGF1-bindingsetel, toon duidelik dat laasgenoemde 'n mengsel van ongewone DNA konformasies, onder die spesifieke eksperimentele omstandigehede, aanneem. Deeglike inspeksie van die beskikbare geen- en proteïendatabasisse vir alle spesies het aangetoon dat suGF1 geen merkbare kDNA- of proteïenhomoloë besit nie. As gevolg van die belang van soogdiermodelsisteme in die mediese wetenskappe, asook die onbeskikbaarheid van seepampoentjie-sellyne, is 'n soektog na 'n funktionele suGF1 homoloog in soogdiere geloods. Die ontdekking van só 'n homoloog sal dit moontlik maak om die rol van hierdie potensiaal belangrike en unieke DNA-bindingsproteïen te ondersoek. Tydens hierdie soektog is spesiale analise-programme gebruik en 'n potensiële menshomoloog van suGF1, hORFX, is geïdentifiseer. Die mees prominente ooreenkoms tussen die twee proteïene is die soortgelyke rangskikking van funksionele motiewe. Gevolglik is die DNA-bindings eienskappe van die hORFX-proteïen ondersoek, insluitende 'n detaileerde struktuur-funksie-voorspelling ten einde vas te stel of dit wél 'n homoloog van suGF1 is. hORFX is suksesvol uitgedruk in vitro, maar besit nie die vermoë om dieselfde G-string waaraan suGF1 spesifiek bind te herken nie. Teoretiese analise het voorspel dat suGF1 en hORFX aan verskillende DNA-bindings proteïen-families behoort, aangesien suGF1 'n heliks-draai-heliks en hORFX 'n heliks-lus-heliks motief bevat. Hierdie inligting, tesame met die eksperimentele resultate, dui aan dat hORFX nie 'n homoloog van suGF1 is nie. Tot op hede is daar niks bekend aangaande suGF1 se funksie in vivo nie. Met die oog op transaktiveringseksperimente in die toekoms, is die ekspressie van suGF1 in gisselle tydens hierdie navorsingsprojek ondersoek. 'n suGF1 ekspressievektor is berei en gebruik om 'n protease-negatiewe gissellyn te transformeer. Kernekstrakte is ondersoek deur SDS-PAGE en elektroforetiese mobiliteitsessais. Daar is gevind dat suGF1 suksesvol uitgedruk is in die gisselle. Die rekombinante suGF1 besit G-volgorde bindingsaktiwiteite soortgelyk aan dié van suGF1 in kernekstrakte van seepampoentjies, asook in vitro getranskribeerde-en getransleerde suGF1. Die kDNA vir suGF1 is ook in silico uitgedruk. Tesame met die SDS-PAGE-resultate het laasgenoemde aangetoon dat die suGF1-kDNA veelvuldige AUG-kodons bevat vir die inisiasie van proteïentranslasie. Dit lei moontlik tot die translasie van 'n reeks proteïenprodukte wat verkort is aan die N-terminale kant, afgesien van die volledige suGF1-proteïen. Die in vitro resultate in geheel is essensieel vir die toekomstige uitvoering en interpretasie van transaktiveringseksperimente. Hierdie projek lê gevolglik die fondasie vir 'n verdere ondersoek na die rol van suGF1 in die regulering van geenuitdrukking.
HLEBIK, SVIATLANA. "BASEL III GLOBAL LIQUIDITY RISK REGULATION FOR BANKING SYSTEMS AND THE ECB QUANTITATIVE POLICY." Doctoral thesis, Università Cattolica del Sacro Cuore, 2016. http://hdl.handle.net/10280/12570.
Full textThis thesis focuses on a crucial and controversial issue - liquidity risk. After the 2007-2008 crisis it became increasingly important. The Central Banks provide required liquidity to minimise the probability of a financial system meltdown by using a wide array of instruments. This thesis proposes an analyses of the European Central Bank quantitative policy, market conditions in which these measures have been taken, and their consistency with the demand for liquidity by the banking system. The Basel III international regulatory framework introduced new liquidity regulations for managing liquidity risk. This study introduces a number of actions that can be performed to improve a bank’s liquidity risk management capabilities. By applying the simulation-based approach to decision making, a sensitivity analysis was used to determine the impact of managerial rulings on liquidity ratio. The present work highlights the importance of the liquidity risk and presents the empirical analysis that allowed the exploration of the relationship between the Basel’s new liquidity requirement (NSFR) and banking stability, macroeconomic and financial markets factors, and central bank operations.
Corrigan, Laura. "Regulation and reproductive functions of membrane-bound vesicles secreted by the Drosophila male accessory gland." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:673d46a5-ba88-42d2-9361-51f04d61e01b.
Full textAljagthmi, Amjad Ahmed. "The regulation of small GTPase Rac1 phosphorylation, activation and subcellular localization by ΔNp63α." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1629746909185699.
Full textFujita, Yasuyuki. "Phosphorylation of Munc-18/n-Secl/rbSecl by Protein Kinase C - Its Implication in Regulating the Interaction of Munc-18/n-Secl/rbSecl with Syntaxin." Kyoto University, 1997. http://hdl.handle.net/2433/202212.
Full textAustin, Heather L. (Heather Lara) 1984. "Effect of Hypo-osmotic Stress on Mortality and Regulation of Volume, Osmolality, and Magnesium Ion Concentrations in the Sea Anemone Metridium senile in South Slough, Coos Bay, Oregon." Thesis, University of Oregon, 2009. http://hdl.handle.net/1794/10150.
Full textThe sea anemone Metridium senile occurs along a salinity gradient in the South Slough Estuary, Oregon, where it is subjected to frequent and sometimes large fluctuations in salinity. This study determined how hypo-osmotic stress contributes to the survival and distribution of this population. In the laboratory, chronic exposure ofM. senile to 50% and 75% seawater for twenty-eight days resulted in partial regulation of volume and magnesium ions. Anemones transplanted to the field exhibited increased mortality and partial regulation of volume, osmolality, and magnesium ions with decreased salinity during the wet season (December-February) and less regulation during the dry season (June-August). This pattern of physiological tolerance coincides with observed trends of seasonal abundance and distribution. Previous studies describe M senile as a marine osmoconformer, however this estuarine population is able to withstand moderate hypo-osmotic stress through partial regulation of tissue osmolality and magnesium ions.
Committee in Charge: Dr. Craig M. Young, Chair; Dr. Nora B. Terwilliger; Dr. Steven S. Rumrill; Dr. Caren E. Braby
Vallejos, Vidal Eva Carolina. "molecular regulation of the immune function in the gills of gilthead sea bream (sparus aurata) fed with immunostimulant diets." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/319686.
Full textOver the past 10 years, different immunostimulants have been tested in more than 18 fish species including: Carp, Yellow croaker, Turbot, Atlantic salmon and Seabream, amongst others. The compounds tested are varied including bacterial components, polysaccharides, animal, plant and algae extract, nutritional factors, and even hormones and cytokines and some synthetics such as Levamisole. However even although a lot of interest and studies have been carried out, commercially available immunostimulant diets mainly contain β-glucans. The majority of the studies reported are based upon cellular response assays such as phagocyte activity and ROS and simple blood measurements such as total serum IgM content. All studies have shown positive results, but little is known about the underlying molecular response to dietary administration of immunostimulants. In order to evaluate the transcriptomic response in gills we analyzed and evaluated gene expression profiles associated with exposure to immunostimulant diets over time, using both a molecular and cellular approach. Experimentally, 360 healthy Gilthead Seabream (Sparus aurata) of average body weight of 38±7.3 g were separated in 27 tanks and fed with two Skretting immunostimulant diets (Diet A and Diet B) and a control diet (Diet C). Each diet were fed at a feeding rate of 3% of body weight twice daily for 28 days with a period of 14 days of pre-acclimation. Gills samples were taken at 2, 7, 14 and 28 days post diet. All samples were divided for microarray analysis (specific Sparus aurata 44K microarray, Agilent custom design) and in situ hybridization (ISH) analysis. A diet dependent and a loop analysis were carried out, with control diet as a reference point. Microarray results shown a differential expression of genes associated to immunological processes such as inflammation, T and B cell response amongst others but the intensity and magnitude of the modulation of these responses was not high. ISH analysis showed localization of immunological transcripts in a specific cellular type in the primary lamellae of gilthead seabream gills.
Lung, Tina Kathy. "Analysis of Mouse EKLF/KLF2 E9.5 Double Knockout: Yolk Sac Morphology and Embryonic Erythroid Maturation." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/1821.
Full textWarner, Frendehl Sipaco. "Caught between 'Dublin' and the deep blue sea: 'small' Member States and European Union 'burden-sharing' responses to the unauthorized entry of seabourne asylum seekers in the Mediterranean from 2005-2010." Thesis, University of Canterbury. National Centre for Research on Europe, 2013. http://hdl.handle.net/10092/9231.
Full textRUBASHKINA, YANA. "Rigore della Politica Ambientale: Misura ed Effetti." Doctoral thesis, Università Cattolica del Sacro Cuore, 2014. http://hdl.handle.net/10280/5966.
Full textThe PhD thesis is about measurement and effects of environmental policy in the context of the Porter Hypothesis (PH). The first chapter offers a critical review of the large empirical literature on the Porter Hypothesis. The second chapter presents an empirical investigation of the Porter Hypothesis focusing on the manufacturing sectors of European countries between 1997 and 2009. We look at overall innovation and productivity impact that are the most relevant indicators for the “strong” PH. This approach allows us to account for potential opportunity costs of induced innovations. As a proxy of environmental policy stringency we use pollution abatement and control expenditures (PACE), which represent one of the few indicators available at the sectoral level. We remedy upon its main drawback, that of potential endogeneity of PACE, by adopting an instrumental variable estimation approach. The third chapter represents a novel approach, inspired by the literature on multilevel latent models and Item Response Theory, to assessing countries’ environmental and energy policy performance. We use data on energy efficiency policy targeting industrial sectors in 27 EU countries between 2004 and 2009 and rank countries with respect to their ability to implement policy over time. Unlike previous contributions in this respect, our model accounts for the inherent difficulty of a given policy instrument mix. Moreover, the model is extended to deal with the longitudinal data and to adjust the country ranking as a result of economic and institutional observables, which are likely to affect policy design and implementation.
Hannesson, Magnus K. "Carriage by sea : the nature of transport documents, carriers and regulation by mandatory conventions; a study in English and Scandinavian law." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280665.
Full textHustedt, Sina. "A Risk Analysis of New Zealand's Biosecurity Management System along Three Sea Importation Pathways." Thesis, University of Canterbury. School of Forestry, 2010. http://hdl.handle.net/10092/3635.
Full textKihara, Akio. "Identification,characterization,and regulation of the proteolytic system that degrades uncomplexed SecY subunit of protein translocase in the Escherichia coli plasma membrane." 京都大学 (Kyoto University), 1998. http://hdl.handle.net/2433/157158.
Full textKyoto University (京都大学)
0048
新制・課程博士
博士(理学)
甲第7164号
理博第1938号
新制||理||1043(附属図書館)
UT51-98-G93
京都大学大学院理学研究科化学専攻
(主査)教授 伊藤 維昭, 教授 井上 丹, 教授 三木 邦夫
学位規則第4条第1項該当
Månsson, Gustav, and Henrik Stale. "Kosten ombord : Hur vill sjömannen att kostregleringen ska se ut?" Thesis, Linnéuniversitetet, Sjöfartshögskolan (SJÖ), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-30420.
Full textKosten anges av många sjömän som ett glädjeämne ombord och ska ge den näring och energi som krävs för att orka med en lång arbetsdag på sjön. Syftet med denna studie var att undersöka om det finns ett behov hos sjömän att få mera information om kostregleringen ombord och om de önskar att den vore utformad annorlunda för att möta deras krav. Arbetet baseras på en litteraturdel där kostregleringen undersöks och en intervjudel med semistrukturerade kvalitativa intervjuer med fem sjömän. Sammanfattningsvis tyder vår undersökning på att sjömän har bristande kännedom om regleringens utformning, var den återfinns samt anser att den är oprecis. Intervjuerna visade att sjömän anser att variation är den viktigaste faktorn i kostintaget och det var också detta uttryck som främst önskades framgå av regleringen. Det finns välmotiverade skäl att utgå från Livsmedelsverkets rekommendationer även på sjön. Ett bra kostintag är inte bara bra för individens hälsa utan ger också vinster i bland annat säkerheten och kvaliteten på utfört arbete.
Khan, Faisal Farooq. "Design, implementation and experimental validation of a network-based model to predict mitotic microtubule regulating proteins." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:7c27b09b-08c3-43f5-93c3-0580cf5fd103.
Full textBuglass, Surahanil Katrin. "Regulating stem cell fate within microenvironmental niches." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:75f9498c-30f0-4983-84b2-dd58f2ccf52b.
Full textVan, Nieuwerburgh Lies. "Experimental Studies on the Regulation of Pigment Dynamics in Phytoplankton and Copepods by Dissolved Inorganic Nutrients." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4230.
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