Relevant bibliographies by topics / Screening, Signalling / Dissertations / Theses
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Dissertations / Theses on the topic 'Screening, Signalling'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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1

MARCHESI, SILVIA. "Screening and Signalling in Debt Strategies: Theory and Empirics." Doctoral thesis, University of Warwick, 2001. http://hdl.handle.net/10281/4658.

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This thesis focuses on public debt under asymmetry of information. The first part of the thesis deals with foreign debt while the second part with domestic debt. In the first part of this work (Chapter 1 and 2) a theoretical model is developed in which adoption of an IMF programme signals a country's productivity. It is assumed that there are two types of country, one with a high return on investment and the other with a low return. The country's type is known only to itself. In the presence of a debt overhang, the high productivity country may choose not to undertake the investment, despite
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2

Lin, Kuan Chee Bevan. "Using the RISCI genetic screening platform for elucidating apoptosis signalling network." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11662.

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Considerable development in the field of nanotechnology is increasingly yielding novel applications of nanoparticles. The unique properties of nanoparticles in particular their high aspect ratio (length : width ratio), however could pose potential risks to the user. A high throughput genetic screening platform, RISCI (robotic single cDNA investigation), was previously established for the systematic evaluation of single gene activities. Here, RISCI was utilised to identify pro-apoptotic genes as well as genes involved in the positive and negative regulation of silica nanoparticle-induced cell d
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3

Lloyd-Lewis, Bethan. "High-throughput screening for novel regulators of Beta-catenin in Wnt signalling." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/24229/.

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Beta-catenin is a crucial component of the Wnt signalling pathway, which is imperative in many developmental processes and aberrantly regulated in several different cancers. The standard model of Wnt/Beta-catenin signalling states that, upon stimulation by Wnt ligand, Beta-catenin accumulates and subsequently translocates to the nucleus to activate TCF-dependent transcription of a variety of target genes, including oncogenes. However, the mechanisms regulating the nuclear localisation of Beta-catenin and its correlation with TCF-dependent transcription are poorly understood. In order to identi
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4

Bielig, Harald Frank Verfasser], Jonathan [Akademischer Betreuer] Howard, and Mats [Akademischer Betreuer] [Paulsson. "Screening for components involved in NLR-mediated immune signalling / Harald Frank Bielig. Gutachter: Jonathan Howard ; Mats Paulsson." Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038226805/34.

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5

Rudge, Felicity. "Genome-wide cDNA and RNAi screening to identify modulators of responses to a novel Wnt signalling inhibitor." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/58589/.

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Wnt/β-catenin signalling plays a central role in the regulation of multicelluar organism development and in the maintenance of tissue homeostasis in adults. Dysregulation of Wnt signalling resulting in aberrant pathway activation is a key initiating step in the development of a diverse range of cancers, including colorectal cancer, and as such is an important target for therapeutic intervention. A novel Wnt pathway inhibitor, ‘MSC’, has been identified as blocking activated Wnt signalling, specifically through inhibiting the ability of CDK8 and CDK19 to activate nuclear β-catenin/TCF-dependent
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Bielig, Harald Frank [Verfasser], Jonathan Akademischer Betreuer] Howard, and Mats [Akademischer Betreuer] [Paulsson. "Screening for components involved in NLR-mediated immune signalling / Harald Frank Bielig. Gutachter: Jonathan Howard ; Mats Paulsson." Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038226805/34.

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7

Matsuo, Koji. "Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells." Kyoto University, 2018. http://hdl.handle.net/2433/232124.

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8

Lago, Cooke Santiago Guillermo. "A novel pipeline for drug discovery in neuropsychiatric disorders using high-content single-cell screening of signalling network responses ex vivo." Thesis, University of Cambridge, 2016. https://www.repository.cam.ac.uk/handle/1810/270297.

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The current work entails the development of a novel high content platform for the measurement of kinetic ligand responses across cell signalling networks at the single-cell level in distinct PBMC subtypes ex vivo. Using automated sample preparation, fluorescent cellular barcoding and flow cytometry the platform is capable of detecting 21, 840 parallel cell signalling responses in each PBMC sample. We apply this platform to characterize the effects of neuropsychiatric treatments and CNS ligands on the T cell signalling repertoire. We apply it to define cell signalling network abnormalities in P
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9

Whalen, Daniel M. "Structural and functional studies of the hedgehog signalling pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ce0e765c-04f1-4a64-a67b-89204ecaa155.

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Hedgehog (Hh) morphogens play fundamental roles in development whilst dysregulation of Hh signalling leads to disease. Multiple receptors are involved in the modulation of Hh morphogens at the cell surface. Among these, the interactions of Hh ligands with glycosaminoglycan (GAG) (for example heparan or chondroitin sulphate) chains of proteoglycans in the extracellular matrix play a key role in shaping morphogen gradients and fulfil important functions in signal transduction. Several high resolution crystal structures of Sonic Hh (Shh)-GAG complexes have been determined. The interaction determi
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10

ALFRED, VICTOR IFEOLUWA. "GENETIC SCREENING TO IDENTIFY INTERACTORS OF ESCRT-II SUBUNIT, VPS25, AND PRELIMINARY CHARACTERISATION OF CANDIDATES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/560382.

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ESCRT (Endosomal Sorting Complex Required for Transport) proteins regulate cell surface receptor degradation by sorting and packaging ubiquitinated cargoes into the intraluminal vesicles of multivesicular bodies (MVBs). A range of human diseases including cancer, and neurodegeneration display altered expression or are caused by mutations of ESCRT subunits. Studies have shown that Drosophila tissues lacking ESCRTs display neoplastic-like features like overproliferation and polarity defects, partly due to aberrant signalling including Notch signalling. To understand ESCRT-regulated processes in
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11

Gianella-Borradori, Matteo Luca. "The identification & optimisation of endogenous signalling pathway modulators." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:4c87de5d-24a7-4998-8edb-917c3922aae1.

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<strong>Chapter 1</strong> Provides an overview of drug discovery with particular emphasis on library selection and hit identification methods using virtual based approaches. <strong>Chapter 2</strong> Gives an outline of the bone morphogenetic protein (BMP) signalling pathway and literature BMP pathway modulators. The association between the regulation of BMP pathway and cardiomyogenesis is also described. <strong>Chapter 3</strong> Describes the use of ligand based virtual screening to discover small molecule activators of the BMP signalling pathway. A robust cell based BMP responsive gene a
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12

Merenda, Alessandra. "Development of a new screening system for the identification of RNF43-related genes and characterisation of other PA-RING family members." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267982.

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The E3 ubiquitin ligase RNF43 (RING finger protein 43) is an important negative modulator of the WNT signalling pathway that acts at the plasma membrane by targeting Frizzled and its co-receptor LRP for degradation. In the small intestine, this prevents uncontrolled expansion of the stem cell compartment and so it is essential to the maintenance of normal tissue homeostasis. However, despite its crucial role in fine-tuning the WNT pathway and its role as a tumour suppressor, it is unclear whether RNF43 has further binding partners and what their functional relevance is to the modulation of WNT
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13

Hamann, Maren [Verfasser]. "The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling : Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation / Maren Hamann." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/1161462295/34.

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14

Sanvitale, Caroline E. "Investigation of kinase activation in fibrodysplasia ossificans progressiva." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3ac802e9-a864-4a0d-8e13-f21bcffc957d.

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Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disease resulting in episodic but progressive extraskeletal bone formation. FOP is caused by missense mutations in the cytoplasmic domain of the type I bone morphogenetic protein (BMP) receptor ACVR1, leading to dysregulated activation. Currently there are no available drug treatments and the structural mechanism of mutant activation is still poorly characterised. To address this, a number of BMP and TGFβ receptors, including FOP mutants of ACVR1 were cloned, expressed and purified for both structural and biophysical expe
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15

Vasou, Andri. "Development of a novel cell-based screening platform to identify inhibitors of viral interferon antagonists from clinically important viruses." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/8266.

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All viruses encode for at least one viral interferon (IFN) antagonist, which is used to subvert the cellular IFN response, a powerful antiviral innate immune response. Numerous in vitro and in vivo studies have demonstrated that IFN antagonism is crucial for virus survival, suggesting that viral IFN antagonists could represent promising therapeutic targets. This study focuses on Respiratory Syncytial Virus (RSV), an important human pathogen for which there is no vaccine or virus-specific antiviral drug. RSV encodes two IFN antagonists NS1 and NS2, which play a critical role in RSV replication
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16

Thalhammer, Armin. "Functional and inhibition studies on 2-oxoglutarate-dependent oxygenases." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:41c3f967-0dd2-47dd-8dd4-bc543b626221.

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This thesis explores roles of 2-oxoglutarate-dependent (2OG) oxygenases as interfaces that modulate steps in the flow of genetic information in cells in response to oxygen availability. Chapter 1 introduces mechanistic, biochemical and physiological aspects of major subfamilies of 2OG oxygenases, and their established regulatory roles in cells. In addition, structural and functional aspects of the ribosome and the translation process are discussed, with a focus on post-translational ribosome modifications. Chapter 2 investigates histone demethylases, which mediate chromatin-dependent regulatio
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17

Imanifard, Zahra. "IDENTIFICATION OF CANDIDATE GENES INVOLVED IN NITRIC OXIDE SIGNALLING DURING HYPERSENSITIVE-CELL DEATH." Doctoral thesis, 2016. http://hdl.handle.net/11562/943497.

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ABSTRACT L’ossido nitrico (NO) è una molecola ampiamente diffusa che regola vari aspetti della crescita della pianta, del suo sviluppo e delle risposte di stress. Diversi studi hanno dimostrato che l’accumulo di NO ed il suo signaling giocano un ruolo importante nella difesa delle piante contro i patogeni. In particolare l’NO gioca un ruolo cruciale nel mediare la risposta di difesa ipersensibile. Questo meccanismo di resistenza implica l’attivazione di una morte cellulare programmata al sito di infezione che ha come obiettivo quello di bloccare l’infezione e la diffusione del patogeno (Jo
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18

Carneiro, Eliana Raquel Dias. "Heterologous expression of human KRASwt cDNA in Saccharomyces cerevisiae and its mutants from the Ras signalling pathway and phenotype screening." Master's thesis, 2015. http://hdl.handle.net/1822/35689.

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Dissertação de mestrado em Genética Molecular<br>Most of our knowledge about basic cellular processes has originated from model organisms. Saccharomyces cerevisiae is consider a model system, representing the simplest eukaryotic organism, whose genome can be easily manipulated allowing suitable analysis and efficient assessment of gene products from humans. RAS genes encode low molecular weight, GTP-binding, GTP-hydrolysing proteins that are highly conserved throughout all eukaryotic species. RAS pathway has attracted attention because of its importance in malignant transformation of hum
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19

Kulpa, Justyna. "Identification of novel regulators of estrogen receptor alpha signalling and proliferation in breast cancer." Thèse, 2017. http://hdl.handle.net/1866/20228.

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20

Hauck, Stefanie M. [Verfasser]. "Neuroprotective pathways in the retina : analysis of GDNF-mediated signalling in retinal Mueller glial cells (RMG) and screening for RMG-derived neurotrophic factors / vorgelegt von Stefanie M. Hauck." 2005. http://d-nb.info/977770893/34.

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