Journal articles: 'Scpi85'

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Ivanova, E. L., M. M. Abelevich, E. F. Lukushkina, E. L. Ivanova, M. V. Abelevich, and E. F. Loukoushkina. "Role of specialized child pre-school institutions in prophylaxis of allergy in children." Russian Journal of Allergy 6, no. 5 (October 15, 2009): 36–43. http://dx.doi.org/10.36691/rja1045.

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Background. To estimate the efficiency of special child pre-school institution (SCPI) in prophylaxis of allergic diseases in children. Methods. 84 children with allergies aged between 10 months and 4 years old were observed. Among them 56 attended the SCPI and 28 (comparative group) attended the basic CPI. All children were passing through clinical, allergological, immunological examination as well as physical and mental development observation. Results. In this research the risks of development of allergies were thoroughly analyzed as well as the results of observation and check-ups of children with allergic diseases who attended to specialized SCPI or basic CPI. In the SCPI dietary conditions were kept, the hypo allergic diet was introduced into practice, the food allowance was balanced in protein, fat, carbohydrates and calorie contents due to physiological needs by substitution of foodstuffs. In the basic CPI these conditions weren't provide. In the SCPIs systematic observation of children is established and the cooperation of parents and doctor in charge of the case allows carrying out continuous pathogenetic therapy. Medical and prophylactic measures decrease the number of allergies' exacerbations and allow parents to proceed their usual activities, also improve the life conditions of children and their parents. Conclusion. The effectiveness of improving of health on the basis of SCPI is approximately 84,5% and the same in basic CPI is 66,75%. The research proposes the method of calculation of needs in SCPI and can be used in the organization of SCPI for children with allergic pathologies.

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Lu, Chen, Shimin Le, Jin Chen, Alicia K. Byrd, Daniela Rhodes, Kevin D. Raney, and Jie Yan. "Direct quantification of the translocation activities of Saccharomyces cerevisiae Pif1 helicase." Nucleic Acids Research 47, no. 14 (June 19, 2019): 7494–501. http://dx.doi.org/10.1093/nar/gkz541.

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AbstractSaccharomyces cerevisiae Pif1 (ScPif1) is known as an ATP-dependent DNA helicase that plays critical roles in a number of important biological processes such as DNA replication, telomere maintenance and genome stability maintenance. Besides its DNA helicase activity, ScPif1 is also known as a single-stranded DNA (ssDNA) translocase, while how ScPif1 translocates on ssDNA is unclear. Here, by measuring the translocation activity of individual ScPif1 molecules on ssDNA extended by mechanical force, we identified two distinct types of ssDNA translocation. In one type, ScPif1 moves along the ssDNA track with a rate of ∼140 nt/s in 100 μM ATP, whereas in the other type, ScPif1 is immobilized to a fixed location of ssDNA and generates ssDNA loops against force. Between the two, the mobile translocation is the major form at nanomolar ScPif1 concentrations although patrolling becomes more frequent at micromolar concentrations. Together, our results suggest that ScPif1 translocates on extended ssDNA in two distinct modes, primarily in a ‘mobile’ manner.

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Wang, Xing, Fei Gao, Jie Bing, Weimin Sun, Xiuxiu Feng, Xiaofeng Ma, Yijun Zhou, and Genfa Zhang. "Overexpression of the Jojoba Aquaporin Gene, ScPIP1, Enhances Drought and Salt Tolerance in Transgenic Arabidopsis." International Journal of Molecular Sciences 20, no. 1 (January 3, 2019): 153. http://dx.doi.org/10.3390/ijms20010153.

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Plasma membrane intrinsic proteins (PIPs) are a subfamily of aquaporin proteins located on plasma membranes where they facilitate the transport of water and small uncharged solutes. PIPs play an important role throughout plant development, and in response to abiotic stresses. Jojoba (Simmondsia chinensis (Link) Schneider), as a typical desert plant, tolerates drought, salinity and nutrient-poor soils. In this study, a PIP1 gene (ScPIP1) was cloned from jojoba and overexpressed in Arabidopsis thaliana. The expression of ScPIP1 at the transcriptional level was induced by polyethylene glycol (PEG) treatment. ScPIP1 overexpressed Arabidopsis plants exhibited higher germination rates, longer roots and higher survival rates compared to the wild-type plants under drought and salt stresses. The results of malonaldehyde (MDA), ion leakage (IL) and proline content measurements indicated that the improved drought and salt tolerance conferred by ScPIP1 was correlated with decreased membrane damage and improved osmotic adjustment. We assume that ScPIP1 may be applied to genetic engineering to improve plant tolerance based on the resistance effect in transgenic Arabidopsis overexpressing ScPIP1.

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Zhang, Zhicong, Fengyu Ji, Shouwen Jiang, Zhichao Wu, and Qianghua Xu. "Scale Development-Related Genes Identified by Transcriptome Analysis." Fishes 7, no. 2 (March 12, 2022): 64. http://dx.doi.org/10.3390/fishes7020064.

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Scales, as key structures of fish skin, play an important role in physiological function. The study of fish scale development mechanisms provides a basis for exploring the molecular-level developmental differences between scaled and non-scaled fishes. In this study, alizarin red staining was used to divide the different stages of zebrafish (Danio rerio) scale development. Four developmental stages, namely stage I (~17 dpf, scales have not started to grow), stage II (~33 dpf, the point at which scales start to grow), stage III (~41 dpf, the period in which the scales almost cover the whole body), and stage IV (~3 mpf, scales cover the whole body), were determined and used for subsequent transcriptome analysis. WGCNA (weighted correlation network analysis) and DEG (differentially expressed gene) analysis were used for screening the key genes. Based on the comparison between stage II and stage I, 54 hub-genes were identified by WGCNA analysis. Key genes including the Scpp family (Scpp7, Scpp6, Scpp5, and Scpp8), the Fgf family (Fgfr1b and Fgfr3), Tcf7, Wnt10b, Runx2b, and Il2rb were identified by DEG analysis, which indicated that these genes played important roles in the key nodes of scale development signal pathways. Combined with this analysis, the TGF-β, Wnt/β-catenin, and FGF signaling pathways were suggested to be the most important signal pathways for scales starting to grow. This study laid a foundation for exploring the scale development mechanism of other fishes. The scale development candidate genes identified in the current study will facilitate functional gene identifications in the future.

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Snow, Bryan E., Maria Mateyak, Jana Paderova, Andrew Wakeham, Caterina Iorio, Virginia Zakian, Jeremy Squire, and Lea Harrington. "Murine Pif1 Interacts with Telomerase and Is Dispensable for Telomere Function In Vivo." Molecular and Cellular Biology 27, no. 3 (November 27, 2006): 1017–26. http://dx.doi.org/10.1128/mcb.01866-06.

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ABSTRACT Pif1 is a 5′-to-3′ DNA helicase critical to DNA replication and telomere length maintenance in the budding yeast Saccharomyces cerevisiae. ScPif1 is a negative regulator of telomeric repeat synthesis by telomerase, and recombinant ScPif1 promotes the dissociation of the telomerase RNA template from telomeric DNA in vitro. In order to dissect the role of mPif1 in mammals, we cloned and disrupted the mPif1 gene. In wild-type animals, mPif1 expression was detected only in embryonic and hematopoietic lineages. mPif1 − / − mice were viable at expected frequencies, displayed no visible abnormalities, and showed no reproducible alteration in telomere length in two different null backgrounds, even after several generations. Spectral karyotyping of mPif1 − / − fibroblasts and splenocytes revealed no significant change in chromosomal rearrangements. Furthermore, induction of apoptosis or DNA damage revealed no differences in cell viability compared to what was found for wild-type fibroblasts and splenocytes. Despite a novel association of mPif1 with telomerase, mPif1 did not affect the elongation activity of telomerase in vitro. Thus, in contrast to what occurs with ScPif1, murine telomere homeostasis or genetic stability does not depend on mPif1, perhaps due to fundamental differences in the regulation of telomerase and/or telomere length between mice and yeast or due to genetic redundancy with other DNA helicases.

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Kucukoglu, Ilker. "Adaptive Electromagnetic Field Optimization Algorithm for the Solar Cell Parameter Identification Problem." International Journal of Photoenergy 2019 (June 3, 2019): 1–16. http://dx.doi.org/10.1155/2019/4692108.

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Solar cell parameter identification problem (SCPIP) is one of the most studied optimization problems in the field of renewable energy since accurate estimation of model parameters plays an important role to increase their efficiency. The SCPIP is aimed at optimizing the performance of solar cells by estimating the best parameter values of the solar cells that produce an accurate approximation between the current vs. voltage (I−V) measurements. To solve the SCPIP efficiently, this paper introduces an adaptive variant of the electromagnetic field optimization (EFO) algorithm, named adaptive EFO (AEFO). The EFO simulates the attraction-repulsion mechanism between particles of electromagnets having different polarities. The main idea behind the EFO is to guide electromagnetic particles towards global optimum by the attraction-repulsion forces and the golden ratio. Distinct from the EFO, the AEFO searches the solution space with an adaptive search procedure. In the adaptive search strategy, the selection probability of a better solution is increased adaptively whereas the selection probability of worse solutions is reduced throughout the search progress. By employing the adaptive strategy, the AEFO is able to maintain the balance between exploration and exploitation more efficiently. Further, new boundary control and randomization procedures for the candidate electromagnets are presented. To identify the performance of the proposed algorithm, two different benchmark problems are taken into account in the computational studies. First, the AEFO is performed on global optimization benchmark functions and compared to the EFO. The efficiency of the AEFO is identified by statistical significance tests. Then, the AEFO is implemented on a well-known SCPIP benchmark problem set formed as a result of real-life physical experiments based on single- and double-diode models. To validate the performance of the AEFO on the SCPIP, extensive experiments are carried out, where the AEFO is tested against the original EFO, AEFO variants, and novel metaheuristic algorithms. Results of the computational studies reveal that the AEFO exhibits superior performance and outperforms other competitor algorithms.

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Muellner, Julius, and Kristina H. Schmidt. "Yeast Genome Maintenance by the Multifunctional PIF1 DNA Helicase Family." Genes 11, no. 2 (February 20, 2020): 224. http://dx.doi.org/10.3390/genes11020224.

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The two PIF1 family helicases in Saccharomyces cerevisiae, Rrm3, and ScPif1, associate with thousands of sites throughout the genome where they perform overlapping and distinct roles in telomere length maintenance, replication through non-histone proteins and G4 structures, lagging strand replication, replication fork convergence, the repair of DNA double-strand break ends, and transposable element mobility. ScPif1 and its fission yeast homolog Pfh1 also localize to mitochondria where they protect mitochondrial genome integrity. In addition to yeast serving as a model system for the rapid functional evaluation of human Pif1 variants, yeast cells lacking Rrm3 have proven useful for elucidating the cellular response to replication fork pausing at endogenous sites. Here, we review the increasingly important cellular functions of the yeast PIF1 helicases in maintaining genome integrity, and highlight recent advances in our understanding of their roles in facilitating fork progression through replisome barriers, their functional interactions with DNA repair, and replication stress response pathways.

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Do, Dao Huu, and Tuan A. Pham. "Investigation of Performance of Soil-Cement Pile in Support of Foundation Systems for High-Rise Buildings." Civil Engineering Journal 4, no. 2 (March 6, 2018): 266. http://dx.doi.org/10.28991/cej-030990.

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This paper presents the experimental study of Soil-Cement Pile (SCpile) by wet mixing method in sandy soils, with the typical project at An Trung Complex apartment, Da Nang city, Vietnam. With the characteristic of soil layers is sandy soil, the strength of laboratory stabilized soils with the amount of cement from 150¸300 kg/m3 was determined. Simultaneously, the authors also performed the experiments of 20 test piles collected from the site which has cement content about 280 kg/m3 and the unconfined compressive strength qu= (4.5-6.0) MPa. After that, a full-scale model static axial compressive load tests of two single piles and a group of four piles with diameter 800 mm and 12 m length were also conducted. The experiment results show that the bearing capacity of every single pile is 1.200 kN with settlement 6.93 mm and the group of four CSpiles is 3.200 kN with settlement 5.03 mm. The results presented in the paper illustrate that SCpile is the suitable solution for foundation construction process with low cost and saving time for high rise buildings. The result shows a capable application of soil cement piles for support of high-rise buildings.

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Qu, Meng, Yali Liu, Yanhong Zhang, Shiming Wan, Vydianathan Ravi, Geng Qin, Han Jiang, et al. "Seadragon genome analysis provides insights into its phenotype and sex determination locus." Science Advances 7, no. 34 (August 2021): eabg5196. http://dx.doi.org/10.1126/sciadv.abg5196.

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The iconic phenotype of seadragons includes leaf-like appendages, a toothless tubular mouth, and male pregnancy involving incubation of fertilized eggs on an open “brood patch.” We de novo–sequenced male and female genomes of the common seadragon (Phyllopteryx taeniolatus) and its closely related species, the alligator pipefish (Syngnathoides biaculeatus). Transcription profiles from an evolutionary novelty, the leaf-like appendages, show that a set of genes typically involved in fin development have been co-opted as well as an enrichment of transcripts for potential tissue repair and immune defense genes. The zebrafish mutants for scpp5, which is lost in all syngnathids, were found to lack or have deformed pharyngeal teeth, supporting the hypothesis that the loss of scpp5 has contributed to the loss of teeth in syngnathids. A putative sex–determining locus encoding a male-specific amhr2y gene shared by common seadragon and alligator pipefish was identified.

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Alawneh, Rami, Ismael Jannoud, Hesham Rabayah, Rana Imam, and Hatem Almasaeid. "Development of an Assessment and Management Framework for Sustainable Construction Projects in Jordan by Incorporating the Sustainable Development Goals." Infrastructures 9, no. 7 (July 21, 2024): 117. http://dx.doi.org/10.3390/infrastructures9070117.

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Countries worldwide have implemented several strategies to achieve the Sustainable Development Goals (SDGs), to which sustainable construction projects can contribute significantly. However, an integrated assessment and management method for sustainable construction projects is needed to improve the contributions of such projects to achieving the SDGs. Hence, this research aims to develop an innovative framework that integrates contributions to achieving the SDGs within the assessment and management of sustainable construction projects. We reviewed previous research and used the Delphi method to identify assessment indicators and construct a framework. Next, two new indices were constructed: the Sustainable Construction Project Indicator Contributions Index (SCPICI) and the Integrated Sustainable Construction Project Contributions Index (ISCPCI). Lastly, a focus group discussion was conducted. According to the SCPICI, the top five indicators are energy-efficient management (27.58), the use of renewable energy (27.51), measurements of energy savings during the construction and operation phases (26.64), water savings during construction and operation phases (26.18), and water recycling (25.46). The research findings indicate that sustainable construction projects substantially contribute to achieving SDGs 3, 6, 7, 8, 9, 11, 12, 13, and 15. Policymakers and other stakeholders in the construction sector could use the proposed framework to assess and manage sustainable construction projects. Moreover, researchers worldwide could use the proposed methods to develop new frameworks in other countries.

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Fang, Yin, Wen-Bo Bo, Ru-Ru Wang, Yue-Yue Wang, and Chao-Qing Dai. "Predicting nonlinear dynamics of optical solitons in optical fiber via the SCPINN." Chaos, Solitons & Fractals 165 (December 2022): 112908. http://dx.doi.org/10.1016/j.chaos.2022.112908.

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Li, Jianjun, Guangsheng Wei, and Chengjin Han. "Fundamental Study on Electric Arc Furnace Steelmaking with Submerged Carbon Powder Injection with CO2-O2 Mixed Gas." Metals 13, no. 9 (September 15, 2023): 1602. http://dx.doi.org/10.3390/met13091602.

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The technology of submerged carbon powder injection with CO2 and O2 mixed gas (SCPI-COMG) is a new type of powder injection technology. It can increase the molten bath carbon content and improve the molten steel quality by injecting carbon powder directly into the molten steel with CO2 and O2 mixed gas. To optimize the process parameters of this novel technology, the mechanism of this technology and the effect of SCPI-COMG on EAF steelmaking were investigated in this study. Based on an induction furnace experiment, the effects of molten bath carburization and fluid flow on the scrap melting were analyzed. A mathematical model of the axis of gas jets in liquid steel was built to analyze the impact behaviors of gas jets in liquid steel. Based on the results of this theoretical model, for a gas jet in liquid steel, with α ≥ 20°, the horizontal inject distance decreases with α increasing and with 0° ≤ α ≤ 20°, the horizontal inject distance increases with α increasing. Finally, based on the newly built materials and energy balance model of EAF steelmaking with SCPI-COMG, the influences of the gas-solid parameters on the EAF steelmaking technical indexes were also analyzed.is very useful for optimizing the process parameters of EAF steelmaking with SCPI-COMG. The results of this study are very useful to optimize the process parameters of EAF steelmaking with SCPI-COMG of Gas Jet in Liquid Steel.

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Kurnia, Anih, Farida Mohd Said, and Santhna Letchmi Paduragan. "The Indonesian Version of the Skills, Confidence, and Preparedness Index (SCPI) was tested for reliability and validity in type 2 diabetes patients." International Journal of Health Sciences 2, no. 1 (March 31, 2024): 472–94. http://dx.doi.org/10.59585/ijhs.v2i1.336.

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Although several diabetes self-care management tools have been created, very few provide preparation for diabetes self-care behavior management. Three essential components of diabetes self-care management are measured by the assessment tool "Skills, Confidence & Preparedness Index (LMC) (SCPI)": Knowledge of skills, Confidence in one's ability to use skills, and Readiness to put skills into practice. This study aims to validate, translate, and adapt the SCPI for usage with Indonesian adults with type 2 diabetes. Methods: The American Academy of Orthopedic Surgeons Evidence Based Medicine Committee (AAOS) criteria for modifying the scale were adhered to in this study. Evaluate average variance, Cronbach alpha, and composite reliability to test validity and reliability. Specifically, determinant coefficient testing and model appropriateness testing are used to assess goodness of fit. Examine the valid R-squared statistical value for every relationship to determine the test. If the p-value is less than 0.05, then there is a direct and indirect association to be seen if the variable is significant Result: Cronbach's alpha > 0.60 indicates strong internal consistency for the Indonesian SCPI version or I-SCPI. For every variable, the AVE value is larger than 0.50, while the CR value exceeds 0.70. This indicates that all legitimate indicators converge to form the variables for which they are intended. The R-Square values of 0.312 and 0.536 for the variables of preparedness and confidence are used to calculate the degree of good fit. This number indicates that the Preparedness variable is only partially explained by the Confidence and Preparedness variables (5.36%), with other variables accounting for the remaining 94.64%. Furthermore, the Skill/Knowledge, Confidence, and Preparedness factors account for only 3% of the variance in the Confidence variable, with the remaining 97% explained by variables outside the model. Conclusion: We developed an Indonesian version of SCPI through cross-cultural translation and adaption. The I-SCPI is reliable and valid for assessing the level of self-management in type 2 diabetes patients in Indonesia

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Tian, Luyi, Shian Su, Xueyi Dong, Daniela Amann-Zalcenstein, Christine Biben, Azadeh Seidi, Douglas J. Hilton, Shalin H. Naik, and Matthew E. Ritchie. "scPipe: A flexible R/Bioconductor preprocessing pipeline for single-cell RNA-sequencing data." PLOS Computational Biology 14, no. 8 (August 10, 2018): e1006361. http://dx.doi.org/10.1371/journal.pcbi.1006361.

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Jia, Zhiwei, Wen Fang, Chenhao Sun, and Ling Li. "Control of a Path Following Cable Trench Caterpillar Robot Based on a Self-Coupling PD Algorithm." Electronics 13, no. 5 (February 28, 2024): 913. http://dx.doi.org/10.3390/electronics13050913.

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Underground cable trench inspection robots work in narrow, variable friction coefficient, and complex road environments. The running trajectory easily deviates from the desired path and leads to a collision, or even the destruction of the robot or cable. Addressing this problem, a path-following control method for the dual-tracked chassis robot based on a self-coupling PID (SCPID) control algorithm was developed. The caterpillar robot dynamics were modelled and both the unknown dynamics and external bounded disturbances were defined as sum disturbances, thus mapping the nonlinear system into a linearly disturbed system, then the self-coupling PD (SCPD) controller was designed. The system proved to be a robust stability control system and only one parameter, the velocity factor, needed to be tuned to achieve parameter calibration. Meanwhile, to solve the problem that the error-based speed factor is not universal and to improve the adaptive ability of the SCPD controller, an iterative method was used for adaptive tuning. The simulation results showed that the SCPID can achieve better control. The field test results showed that the SCPD’s maximum offset angle was 56.7% and 10.3% smaller than incremental PID and sliding mode control (SMC), respectively. The inspection time of the SCPD was 20% faster than other methods in the same environment.

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Mecadon-Mann, Melissa, and Malti Tuttle. "School Counselor Professional Identity in Relation to Post-Master’s Supervision." Professional School Counseling 27, no. 1 (January 2023): 2156759X2211439. http://dx.doi.org/10.1177/2156759x221143932.

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School counselors may choose to pursue clinical supervision after they graduate from a master’s program even though they are not required to do so. This quantitative study utilized a survey research design to examine the differences between school counselor professional identity (SCPI) development and post-master’s supervision. Results from this study indicate significant differences in components of SCPI between school counselors who participated in post-master’s supervision and those who did not. School counselors who pursued post-master’s supervision had stronger identity scores focused on roles and responsibilities, leadership, and social justice advocacy.

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Quinteros Urquieta, Carolina, and Rodrigo Marcelo Cortés Mancilla. "El sueño de la casa propia: entre la ilusión neoliberal y la resistencia colectiva." Cuadernos de Vivienda y Urbanismo 15, no. 1 (August 10, 2022): 27. http://dx.doi.org/10.11144/javeriana.cvu15.scpi.

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El problema de acceso a la vivienda en Chile no es un fenómeno nuevo. Si bien la implementación del sistema de subsidio habitacional por parte del Estado, bajo un modelo neoliberal, logró disminuir el déficit habitacional, estas cifras se han revertido y uno de sus efectos ha sido el aumento de tomas de terreno y campamentos. Ejemplo de esto es la ciudad de Viña del Mar, que tiene los dos campamentos más grandes del país y con más familias en estos espacios. A partir del trabajo en co-labor con las y los dirigentes del campamento Felipe Camiroaga, se realiza un análisis del proceso de articulación, así como de las prácticas y trayectoria de sus habitantes en relación a la política habitacional neoliberal chilena y su idea-eslogan del “sueño de la casa propia”. De lo anterior se desprenden los resultados, expresados en estrategias de sus pobladores y pobladoras para resistir a la exigencia neoliberal de lo individual, a través del trabajo colectivo en momentos de la historia del campamento

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NAKASHIMA, Satoru, Yutaka IKENO, Tatsuya YOKOYAMA, Masakazu KUWANA, Angelo BOLCHI, Simone OTTONELLO, Katsuhiko KITAMOTO, and Manabu ARIOKA. "Secretory phospholipases A2 induce neurite outgrowth in PC12 cells." Biochemical Journal 376, no. 3 (December 15, 2003): 655–66. http://dx.doi.org/10.1042/bj20030830.

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sPLA2s (secretory phospholipases A2) belong to a broad and structurally diverse family of enzymes that hydrolyse the sn-2 ester bond of glycerophospholipids. We previously showed that a secreted fungal 15 kDa protein, named p15, as well as its orthologue from Streptomyces coelicolor (named Scp15) induce neurite outgrowth in PC12 cells at nanomolar concentrations. We report here that both p15 and Scp15 are members of a newly identified group of fungal/bacterial sPLA2s. The phospholipid-hydrolysing activity of p15 is absolutely required for neurite outgrowth induction. Mutants with a reduced PLA2 activity exhibited a comparable reduction in neurite-inducing activity, and the ability to induce neurites closely matched the capacity of various p15 forms to promote fatty acid release from live PC12 cells. A structurally divergent member of the sPLA2 family, bee venom sPLA2, also induced neurites in a phospholipase activity-dependent manner, and the same effect was elicited by mouse group V and X sPLA2s, but not by group IB and IIA sPLA2s. Lysophosphatidylcholine, but not other lysophospholipids, nor arachidonic acid, elicited neurite outgrowth in an L-type Ca2+ channel activity-dependent manner. In addition, p15-induced neuritogenesis was unaffected by various inhibitors that block arachidonic acid conversion into bioactive eicosanoids. Altogether, these results delineate a novel, Ca2+- and lysophosphatidylcholine-dependent neurotrophin-like role of sPLA2s in the nervous system.

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Widyastuti, Indriyana, and Saptani Rahayu. "Akurasi Potensi Memprediksi Kebangkrutan Metode Altman Z-Score Dan Metode Ohlson O-Score." ProBank 3, no. 2 (November 18, 2018): 1–7. http://dx.doi.org/10.36587/probank.v3i2.369.

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Penelitian ini bertujuan untuk mengetahui tingkat akurasi prediksi kebangkrutan perusahaan farmasi di Indonesia dengan membandingkan model prediksi Altman Z-Score dengan Olhson dilihat dari aspek kinerja keuangan. Data yang digunakan dalam penelitian ini merupakan data sekunder pada perusahaan farmasi yang terdaftar di Bursa Efek Indonesia (BEI) periode 2013-2016. Pengujian hipotesis menggunakan alat analisis teknik uji beda independent sampel t-test. Hasil pengujian menunjukkan terdapat perbedaan yang signifikan antara kedua model dalam memprediksi potensi kebangkrutan. Hasil akhir penelitian ini menunjukkan bahwa terdapat dua perusahaan yang diprediksi berpotensi mengalami kebangkrutan dengan menggunakan kedua model prediksi Altman dan Ohlson. Kedua perusahaan tersebut adalah PT Indofarma, Tbk., (INAF) dan PT Merck Sharp Dohme Pharma, Tbk., (SCPI). Berdasarkan Model Altman, PT Indofarma, Tbk., (INAF) berpotensi bangkrut pada tahun 2013 dan 2015, dan PT Merck Sharp Dohme Pharma, Tbk., (SCPI) pada tahun 2013 dan 2014, serta pada PT Pyridam Farma Tbk., (PYFA) dalam kategori rawan bangkrut pada tahun 2013-2016. Berdasarkan Model Ohlson, PT Indofarma, Tbk., (INAF) berpotensi bangkrut pada tahun 2014 dan 2016, dan PT Merck Sharp Dohme Pharma, Tbk., (SCPI) pada tahun 2015 dan 2016.Kata Kunci: Perusahaan Farmasi, Kebangkrutan, Altman Z-Score, Ohlson

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Widyastuti, Indriyana, and Saptani Rahayu. "Akurasi Potensi Memprediksi Kebangkrutan Metode Altman Z-Score Dan Metode Ohlson O-Score." ProBank 3, no. 2 (November 18, 2018): 1–7. http://dx.doi.org/10.36587/probank.v3i2.369.

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Penelitian ini bertujuan untuk mengetahui tingkat akurasi prediksi kebangkrutan perusahaan farmasi di Indonesia dengan membandingkan model prediksi Altman Z-Score dengan Olhson dilihat dari aspek kinerja keuangan. Data yang digunakan dalam penelitian ini merupakan data sekunder pada perusahaan farmasi yang terdaftar di Bursa Efek Indonesia (BEI) periode 2013-2016. Pengujian hipotesis menggunakan alat analisis teknik uji beda independent sampel t-test. Hasil pengujian menunjukkan terdapat perbedaan yang signifikan antara kedua model dalam memprediksi potensi kebangkrutan. Hasil akhir penelitian ini menunjukkan bahwa terdapat dua perusahaan yang diprediksi berpotensi mengalami kebangkrutan dengan menggunakan kedua model prediksi Altman dan Ohlson. Kedua perusahaan tersebut adalah PT Indofarma, Tbk., (INAF) dan PT Merck Sharp Dohme Pharma, Tbk., (SCPI). Berdasarkan Model Altman, PT Indofarma, Tbk., (INAF) berpotensi bangkrut pada tahun 2013 dan 2015, dan PT Merck Sharp Dohme Pharma, Tbk., (SCPI) pada tahun 2013 dan 2014, serta pada PT Pyridam Farma Tbk., (PYFA) dalam kategori rawan bangkrut pada tahun 2013-2016. Berdasarkan Model Ohlson, PT Indofarma, Tbk., (INAF) berpotensi bangkrut pada tahun 2014 dan 2016, dan PT Merck Sharp Dohme Pharma, Tbk., (SCPI) pada tahun 2015 dan 2016.Kata Kunci: Perusahaan Farmasi, Kebangkrutan, Altman Z-Score, Ohlson

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Yukhimenko, Lilia. "ELECTROENCEPHALOGRAPHIC CORRELATES OF THE SPEED (TIME) OF THE CENTRAL PROCESSING OF INFORMATION BY THE HIGHER PARTS OF BRAIN IN HUMANS WITH THE DIFFERENT INDIVIDUAL-TYPOLOGICAL FEATURES OF THE HIGHER NERVOUS ACTIVITY." EUREKA: Life Sciences 2 (March 31, 2016): 51–56. http://dx.doi.org/10.21303/2504-5695.2016.00068.

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The speed (time) of the central processing of information (SCPI) by the higher parts of brain and electric activity of the cerebral cortex were studied using the method of electroencephalography (EEG) in humans with the different individual-typological features of the higher nervous activity – functional mobility of the nervous processes (FMNP). The statistically important differences of indices of the complicated sensorimotor reactions of differentiation, SCPI and EEG powers between the groups of examined were established. The persons with the high FMNP level were characterized with the reliably higher CPI speed and power of α-rhythm of the convexital surface of the cerebral cortex, especially right hemisphere and β-rhythm of EEG (р≤0,001) comparing with examined persons with the mean and low FMNP levels. The correlative analysis proved the reliability of the connections between FMNP, SCPI and EEG characteristics. We think that the established EEG-correlates of the central processing of information by the higher parts of brain increase the predictability of analysis of typological features of the higher nervous activity and can be useful in the field of professional orientation and selection and also in psychodiagnostics of neurological disorders.

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Zillober, C. "SCPIP - an efficient software tool for the solution of structural optimization problems." Structural and Multidisciplinary Optimization 24, no. 5 (November 1, 2002): 362–71. http://dx.doi.org/10.1007/s00158-002-0248-5.

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Koonpaew, Surapong, Challika Kaewborisuth, Kanjana Srisutthisamphan, Asawin Wanitchang, Theeradej Thaweerattanasinp, Janya Saenboonrueng, Sukontip Poonsuk, et al. "A Single-Cycle Influenza A Virus-Based SARS-CoV-2 Vaccine Elicits Potent Immune Responses in a Mouse Model." Vaccines 9, no. 8 (August 3, 2021): 850. http://dx.doi.org/10.3390/vaccines9080850.

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The use of virus-vectored platforms has increasingly gained attention in vaccine development as a means for delivering antigenic genes of interest into target hosts. Here, we describe a single-cycle influenza virus-based SARS-CoV-2 vaccine designated as scPR8-RBD-M2. The vaccine utilizes the chimeric gene encoding 2A peptide-based bicistronic protein cassette of the SARS-CoV-2 receptor-binding domain (RBD) and influenza matrix 2 (M2) protein. The C-terminus of the RBD was designed to link with the cytoplasmic domain of the influenza virus hemagglutinin (HA) to anchor the RBD on the surface of producing cells and virus envelope. The chimeric RBD-M2 gene was incorporated in place of the HA open-reading frame (ORF) between the 3′ and 5′ UTR of HA gene for the virus rescue in MDCK cells stably expressing HA. The virus was also constructed with the disrupted M2 ORF in segment seven to ensure that M2 from the RBD-M2 was utilized. The chimeric gene was intact and strongly expressed in infected cells upon several passages, suggesting that the antigen was stably maintained in the vaccine candidate. Mice inoculated with scPR8-RBD-M2 via two alternative prime-boost regimens (intranasal-intranasal or intranasal-intramuscular routes) elicited robust mucosal and systemic humoral immune responses and cell-mediated immunity. Notably, we demonstrated that immunized mouse sera exhibited neutralizing activity against pseudotyped viruses bearing SARS-CoV-2 spikes from various variants, albeit with varying potency. Our study warrants further development of a replication-deficient influenza virus as a promising SARS-CoV-2 vaccine candidate.

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Karagic, Nidal, Ralf F. Schneider, Axel Meyer, and C. Darrin Hulsey. "A Genomic Cluster Containing Novel and Conserved Genes is Associated with Cichlid Fish Dental Developmental Convergence." Molecular Biology and Evolution 37, no. 11 (June 24, 2020): 3165–74. http://dx.doi.org/10.1093/molbev/msaa153.

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Abstract The two toothed jaws of cichlid fishes provide textbook examples of convergent evolution. Tooth phenotypes such as enlarged molar-like teeth used to process hard-shelled mollusks have evolved numerous times independently during cichlid diversification. Although the ecological benefit of molar-like teeth to crush prey is known, it is unclear whether the same molecular mechanisms underlie these convergent traits. To identify genes involved in the evolution and development of enlarged cichlid teeth, we performed RNA-seq on the serially homologous-toothed oral and pharyngeal jaws as well as the fourth toothless gill arch of Astatoreochromis alluaudi. We identified 27 genes that are highly upregulated on both tooth-bearing jaws compared with the toothless gill arch. Most of these genes have never been reported to play a role in tooth formation. Two of these genes (unk, rpfA) are not found in other vertebrate genomes but are present in all cichlid genomes. They also cluster genomically with two other highly expressed tooth genes (odam, scpp5) that exhibit conserved expression during vertebrate odontogenesis. Unk and rpfA were confirmed via in situ hybridization to be expressed in developing teeth of Astatotilapia burtoni. We then examined expression of the cluster’s four genes in six evolutionarily independent and phylogenetically disparate cichlid species pairs each with a large- and a small-toothed species. Odam and unk commonly and scpp5 and rpfA always showed higher expression in larger toothed cichlid jaws. Convergent trophic adaptations across cichlid diversity are associated with the repeated developmental deployment of this genomic cluster containing conserved and novel cichlid-specific genes.

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Byrd, Alicia K., and Kevin D. Raney. "Structure and function of Pif1 helicase." Biochemical Society Transactions 45, no. 5 (September 12, 2017): 1159–71. http://dx.doi.org/10.1042/bst20170096.

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Pif1 family helicases have multiple roles in the maintenance of nuclear and mitochondrial DNA in eukaryotes. Saccharomyces cerevisiae Pif1 is involved in replication through barriers to replication, such as G-quadruplexes and protein blocks, and reduces genetic instability at these sites. Another Pif1 family helicase in S. cerevisiae, Rrm3, assists in fork progression through replication fork barriers at the rDNA locus and tRNA genes. ScPif1 (Saccharomyces cerevisiae Pif1) also negatively regulates telomerase, facilitates Okazaki fragment processing, and acts with polymerase δ in break-induced repair. Recent crystal structures of bacterial Pif1 helicases and the helicase domain of human PIF1 combined with several biochemical and biological studies on the activities of Pif1 helicases have increased our understanding of the function of these proteins. This review article focuses on these structures and the mechanism(s) proposed for Pif1's various activities on DNA.

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Scherleitner, Moritz. "Article: The Fundamental Freedoms and the Taxation of Dividends Received by Non-resident Investment Funds: Some Thoughts on Non-discrimination With a Special Focus on Recent ECJ Case Law." Intertax 50, Issue 6/7 (June 1, 2022): 484–98. http://dx.doi.org/10.54648/taxi2022046.

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This objective of this article is to discuss outbound cases involving investment funds focusing particularly on the issue of discrimination. The motivation to engage in this inquiry is two-fold. On the one hand, the fund taxation systems in Fidelity and Köln-Aktie Deka Funds include requirements not found in those fund taxation regimes subject to ECJ scrutiny long ago. It is of interest to analyse to what extent this can make a difference. Secondly, the opinions of AG Saugmandsgaard Øe in A SCPI and AG Kokott in Allianzgi merit a closer examination. In the case of the former, it is the AG’s unique approach to comparability that necessitates analysis. In the latter case, it is the variety of far-reaching questions raised by this complex case. EU law, comparability, ECJ, investment funds, fundamental freedoms, Allianzgi, A SCPI, Fidelity, Köln-Aktie Deka Funds.

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Stamhuis, E., and J. Videler. "Quantitative flow analysis around aquatic animals using laser sheet particle image velocimetry." Journal of Experimental Biology 198, no. 2 (February 1, 1995): 283–94. http://dx.doi.org/10.1242/jeb.198.2.283.

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Two alternative particle image velocimetry (PIV) methods have been developed, applying laser light sheet illumination of particle-seeded flows around marine organisms. Successive video images, recorded perpendicular to a light sheet parallel to the main stream, were digitized and processed to map the flow velocity in two-dimensional planes. In particle tracking velocimetry (PTV), displacements of single particles in two subsequent images were determined semi-automatically, resulting in flow diagrams consisting of non-uniformly distributed velocity vectors. Application of grid-cell averaging resulted in flow field diagrams with uniform vector distribution. In sub-image correlation PIV (SCPIV), repetitive convolution filtering of small sub-areas of two subsequent images resulted in automatic determination of cross-correlation peaks, yielding flow field diagrams with regularly spaced velocity vectors. In both PTV and SCPIV, missing values, caused by incomplete particle displacement information in some areas of the images or due to rejection of some erroneous vectors by the vector validation procedure, were interpolated using a two-dimensional spline interpolation technique. The resultant vector flow fields were used to study the spatial distribution of velocity, spatial acceleration, vorticity, strain and shear. These flow fields could also be used to test for flow in the third dimension by studying the divergence, and to detect the presence and location of vortices. The results offer detailed quantitative descriptions of the flow morphology and can be used to assess dissipated energy. The versatile character of the technique makes it applicable to a wide range of fluid mechanical subjects within biological research. So far it has been successfully applied to map the flow around swimming copepods, fish larvae and juvenile fish and the ventilation current of a tube-living shrimp.

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Ghobakhloo, Morteza, and Tang Sai Hong. "The Business Value of Information System-Enabled E-Collaboration Capabilities." International Journal of e-Collaboration 11, no. 1 (January 2015): 22–56. http://dx.doi.org/10.4018/ijec.2015010103.

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This study aims to understand how firms in developing countries can effectively use their Information System (IS) resources to develop valuable e-collaboration capabilities that in turn improve business performance. A questionnaire-based survey was conducted to collect data from 408 Iranian and Malaysian manufacturing firms. Findings revealed that Supply Chain-Wide Process Integration (SCPI) and Collaborative Knowledge Management (CKM) are key IS-enabled capabilities that enhance performance gain of manufacturing firms. The work found that these capabilities serve as catalysts in transforming the value of IS resources controlled by firms into business performance improvement. The results suggest that SCPI, as a determinant of a highly integrated and dynamic supply chain, is an important intermediate organizational capability through which value of IS resources can be materialized. Likewise, the findings imply that CKM across a given supply network, as a valuable intermediate organizational capability, converts the benefits of both technical and human IS resources into performance gain at the corporate level.

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Aravind Balaji, B., S. Sasikumar, and K. Ramesh. "SCPI based integrated test and measurement environment using LabVIEW." IOP Conference Series: Materials Science and Engineering 1045, no. 1 (February 1, 2021): 012036. http://dx.doi.org/10.1088/1757-899x/1045/1/012036.

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NAKASHIMA, Satoru, Shuji WAKATSUKI, Tatsuya YOKOYAMA, Manabu ARIOKA, and Katsuhiko KITAMOTO. "Identification and Characterization of Scp15, a Protein fromStreptomyces coelicolorA3(2) Inducing Neurites in PC12 Cells." Bioscience, Biotechnology, and Biochemistry 67, no. 1 (January 2003): 77–82. http://dx.doi.org/10.1271/bbb.67.77.

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Wulandari, Arifah, Diniy Hidayatur Rahman, and IM Hambali. "The development and validation of student career planning inventory (SCPI)." ProGCouns: Journal of Professionals in Guidance and Counseling 4, no. 2 (November 28, 2023): 62–70. http://dx.doi.org/10.21831/progcouns.v4i2.64714.

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The fluctuating, dynamic and unpredictable development of the work setting Emphasizes the significance of career planning. However, there is still no measurement tool for planning skills based on career construction theory. The objective of this research is to develop and validate an inventory that can measure the level of students' career planning skills based on career construction theory. This research used the ADDIE research design with five development stages including analysis, design, development, implementation, and evaluation. The resulting items amounted to 29 statement items developed from three indicators that are crystallization of vocational preferences, specification of occupational choice and actualization of occupational choice. 112 vocational students were involved in the process of analyzing the instrument validity and reliability. The results of the analysis with the Pearson Product Moment Correlation test resulted in an r-count value above 0.5 with an r-table of 0.195 so that the instrument has high validity. The reliability test with Cronbach's Alpha resulted in a value of 0.972 so that the instrument is highly reliable. Exploratory factor analysis also resulted in the finding that the inventory items developed were formed by three factors namely crystallization of vocational preferences, specification of occupational choices, and actualization of occupational choices.

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Shabelnikov, A. N., I. A. Olgeizer, and A. V. Sukhanov. "Concept of Digital Platform at Marshalling Yards." World of Transport and Transportation 19, no. 1 (September 8, 2021): 60–73. http://dx.doi.org/10.30932/1992-3252-2021-19-1-60-73.

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Implementation of the Industry 4.0 concept is considered in the context of automation of railway transport. The analysis refers to prerequisites for creation of a universal digital platform integrating automation systems at a marshalling yard.The example of JSC Russian Railways has contributed to describe the main goals of Digital Station concept, aimed at fusion of data from low-level local automation equipment. The presented functionality of the system for control and processing information on movements of wagons and locomotives at the station in real time (SCPI MWL RT) implements the set goals by integrating initial data from all automation and centralised traffic control systems operating at the station, checking it for consistency, eliminating information redundancy and generating in real time the current model of a marshalling yard regarding trains and wagons and based on data «from the wheel».Description of the existing functionality of SCPI MWL RT, implemented at a facility, is followed by the analysis of the advantages of this system for the railway cargo transportation network. The objective of the paper is to present some previously unpublished technical solutions for implementation of the specified functionality. The methods of the research are based on fusion of heterogeneous data received from floor devices, specialised video cameras, as well as from real-time wagon positioning models.It is shown that adoption of new technical solutions for SCPI MWL RT will allow to considerably improve the quality of planning of technological process of classifying railway wagons and of forecasting the need for infrastructure maintenance. Deep learning algorithms presented ensure functioning of the developed solutions in real time with high accuracy. Further steps described refer to implementation of a digital platform in the form of a digital twin of a marshalling yard, creating thus a prerequisite for development of an intelligent automatic machine to control the marshalling yard, as well as for further planned ways to implementation there-of.

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Gildor, Tsvia, Revital Shemer, Avigail Atir-Lande, and Daniel Kornitzer. "Coevolution of Cyclin Pcl5 and Its Substrate Gcn4." Eukaryotic Cell 4, no. 2 (February 2005): 310–18. http://dx.doi.org/10.1128/ec.4.2.310-318.2005.

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ABSTRACT Gcn4, a transcription factor that plays a key role in the response of Saccharomyces cerevisiae to amino acid starvation, is regulated at both the levels of translation and of protein stability. Regulated degradation of Gcn4 depends on its phosphorylation by the cyclin-dependent kinase Pho85, in conjunction with the cyclin Pcl5. The pathogenic yeast Candida albicans contains a functional homolog of Gcn4, which is involved in amino acid metabolism, as well as in the regulation of filamentous growth in response to starvation. Here, we show that C. albicans Gcn4 (CaGcn4) is rapidly degraded and that this degradation depends on a Pho85 cyclin homolog, CaPcl5. The regulatory loop that includes Gcn4 and Pcl5 is conserved in C. albicans: like in S. cerevisiae, CaPcl5 is transcriptionally induced by CaGcn4 and is required for CaGcn4 degradation. However, the proteins have coevolved so that there is no cross-recognition between the proteins from the two species: phosphorylation-dependent degradation of CaGcn4 occurs only in the presence of CaPcl5, and S. cerevisiae Gcn4 (ScGcn4) requires ScPcl5 for its degradation. Phenotypic analysis of the Capcl5 mutant indicates that CaPcl5 also modulates the filamentous response of C. albicans in amino acid-rich media.

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Banerjee, Dibyendu, Gaelle Lelandais, Sudhanshu Shukla, Gauranga Mukhopadhyay, Claude Jacq, Frederic Devaux, and Rajendra Prasad. "Responses of Pathogenic and Nonpathogenic Yeast Species to Steroids Reveal the Functioning and Evolution of Multidrug Resistance Transcriptional Networks." Eukaryotic Cell 7, no. 1 (November 9, 2007): 68–77. http://dx.doi.org/10.1128/ec.00256-07.

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ABSTRACT Steroids are known to induce pleiotropic drug resistance states in hemiascomycetes, with tremendous potential consequences for human fungal infections. Our analysis of gene expression in Saccharomyces cerevisiae and Candida albicans cells subjected to three different concentrations of progesterone revealed that their pleiotropic drug resistance (PDR) networks were strikingly sensitive to steroids. In S. cerevisiae, 20 of the Pdr1p/Pdr3p target genes, including PDR3 itself, were rapidly induced by progesterone, which mimics the effects of PDR1 gain-of-function alleles. This unique property allowed us to decipher the respective roles of Pdr1p and Pdr3p in PDR induction and to define functional modules among their target genes. Although the expression profiles of the major PDR transporters encoding genes ScPDR5 and CaCDR1 were similar, the S. cerevisiae global PDR response to progesterone was only partly conserved in C. albicans. In particular, the role of Tac1p, the main C. albicans PDR regulator, in the progesterone response was apparently restricted to five genes. These results suggest that the C. albicans and S. cerevisiae PDR networks, although sharing a conserved core regarding the regulation of membrane properties, have different structures and properties. Additionally, our data indicate that other as yet undiscovered regulators may second Tac1p in the C. albicans drug response.

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Zhang, Ren, Bongjoon Lee, Christopher M. Stafford, Jack F. Douglas, Andrey V. Dobrynin, Michael R. Bockstaller, and Alamgir Karim. "Entropy-driven segregation of polymer-grafted nanoparticles under confinement." Proceedings of the National Academy of Sciences 114, no. 10 (February 22, 2017): 2462–67. http://dx.doi.org/10.1073/pnas.1613828114.

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The modification of nanoparticles with polymer ligands has emerged as a versatile approach to control the interactions and organization of nanoparticles in polymer nanocomposite materials. Besides their technological significance, polymer-grafted nanoparticle (PGNP) dispersions have attracted interest as model systems to understand the role of entropy as a driving force for microstructure formation. For instance, densely and sparsely grafted nanoparticles show distinct dispersion and assembly behaviors within polymer matrices due to the entropy variation associated with conformational changes in brush and matrix chains. Here we demonstrate how this entropy change can be harnessed to drive PGNPs into spatially organized domain structures on submicrometer scale within topographically patterned thin films. This selective segregation of PGNPs is induced by the conformational entropy penalty arising from local perturbations of grafted and matrix chains under confinement. The efficiency of this particle segregation process within patterned mesa−trench films can be tuned by changing the relative entropic confinement effects on grafted and matrix chains. The versatility of topographic patterning, combined with the compatibility with a wide range of nanoparticle and polymeric materials, renders SCPINS (soft-confinement pattern-induced nanoparticle segregation) an attractive method for fabricating nanostructured hybrid films with potential applications in nanomaterial-based technologies.

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Hu, Cong, Shi You Guan, and Da Wei Huang. "Research on Key Technologies of LXI Class C Instrument." Applied Mechanics and Materials 44-47 (December 2010): 3249–53. http://dx.doi.org/10.4028/www.scientific.net/amm.44-47.3249.

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This paper briefly introduces the features and technical points of the new generation of instrument bus LXI (Lan eXtension for Instrument). Taking the deep study of LXI standard, VXI-11 protocol, RPC principles and SCPI commands as the research base, the structure of LXI Class C instrument is analysized, and the LXI Class C instrument key technologies--discovery mechanism and instrument command interpretation mechanism were especially highlighted. Moreover, the discovery mechanism and instrument command interpretation mechanism were implemented in the platform of S3C2410/Linux embedded system, and were successfully validated through Agilent IO Libraries Suite.

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Aronson, Ronnie, Aihua Li, Ruth E. Brown, Ashleigh Walker, Ashley Lyons, and Naomi Orzech. "Optimizing Diabetes Self-management Using the Novel Skills, Confidence, and Preparedness Index (SCPI)." Diabetes Care 42, no. 10 (August 9, 2019): 1873–78. http://dx.doi.org/10.2337/dc19-0699.

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Nikat, R. F., A. Henukh, M. Simbolon, A. Reski, and D. K. Sari. "Scaffolding computer packet instruction (SCPI) to analyze student’s problem solving performance on physics." Journal of Physics: Conference Series 1569 (July 2020): 042084. http://dx.doi.org/10.1088/1742-6596/1569/4/042084.

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Zheng, Jia Jia. "GPIB Communication Design of Programmable Instrument." Applied Mechanics and Materials 539 (July 2014): 527–33. http://dx.doi.org/10.4028/www.scientific.net/amm.539.527.

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GPIB (General Purpose Interface Bus) is the international instrument interface standard. From the perspective of programmable instrument implementing GPIB communication, the paper describes the mode of NAT9914 implementing GPIB communication in details. America National Instrument Company is the leader of GPIB technique. The paper uses GPIB communication card and communication software NI488.2 of NI Corporation to verify the designed GPIB communication interface. In the program, GPIB communication interface is applied to the communication of programmable power supply of computer. The paper makes systematic introduction on standard command for programmable instrument and applies SCPI to control program-controlled power supply.

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Hudnurkar, Manoj, Urvashi Rathod, Suresh Kumar Jakhar, and Omkarprasad S. Vaidya. "Development of a balanced scorecard-based supplier collaborative performance index." International Journal of Productivity and Performance Management 67, no. 2 (February 12, 2018): 401–25. http://dx.doi.org/10.1108/ijppm-05-2016-0084.

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Purpose The purpose of this paper is to design and develop a balanced scorecard (BSC)-based index for quantifying the suitability of suppliers to mature to the next level of collaboration with the buyer company. Design/methodology/approach A BSC-based decision framework was developed using factors and factor indicators affecting collaboration with the supplier, using exploratory research. The proposed decision framework was implemented as a real-world case study in an Indian manufacturing organisation by using the Analytic Hierarchy Process. An 11-step methodology was developed to quantify supplier suitability to mature to the next level of collaboration. This is referred to as the “supplier collaborative performance index” (SCPI). Findings The proposed decision-making framework helps quantify the extent of collaboration with each supplier. It serves as an index by using the perspectives that are significant for the strategic performance of the buyer company, the factors that affect the collaboration and their specific factor indicators. The initial results of the implementation of the case study were found to be useful in judging supplier suitability in order to mature in their relationship. Practical implications A comprehensive BSC-based framework for enhancing relationships with suppliers, SCPI will be instrumental in deciding, managing and improving the level of collaboration with suppliers in manufacturing companies, depending on priorities. Originality/value This approach provides a single index to establish the supplier’s suitability to mature to the next level of collaboration with a buyer company. The higher the value of the Collaboration Index for a supplier, the better is the chance to move to the next level of maturity.

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Haghighi, Morteza, Mohammad Hossein Taghdisi, Haidar Nadrian, Hamed Rezakhani Moghaddam, Hassan Mahmoodi, and Iraj Alimohammadi. "Safety Culture Promotion Intervention Program (SCPIP) in an oil refinery factory: An integrated application of Geller and Health Belief Models." Safety Science 93 (March 2017): 76–85. http://dx.doi.org/10.1016/j.ssci.2016.11.019.

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Papagiannopoulos, Aristeidis, Anastasia Christoulaki, Nikolaos Spiliopoulos, Alexandros Vradis, Chris Toprakcioglu, and Stergios Pispas. "Complexation of Lysozyme with Adsorbed PtBS-b-SCPI Block Polyelectrolyte Micelles on Silver Surface." Langmuir 31, no. 2 (January 6, 2015): 685–94. http://dx.doi.org/10.1021/la504873h.

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Paul, Sanjoy, Jennifer A. Schmidt, and W. Scott Moye-Rowley. "Regulation of the CgPdr1 Transcription Factor from the Pathogen Candida glabrata." Eukaryotic Cell 10, no. 2 (December 3, 2010): 187–97. http://dx.doi.org/10.1128/ec.00277-10.

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ABSTRACTCandida glabratais an opportunistic human pathogen that is increasingly associated with candidemia, owing in part to the intrinsic and acquired high tolerance the organism exhibits for the important clinical antifungal drug fluconazole. This elevated fluconazole resistance often develops through gain-of-function mutations in the zinc cluster-containing transcriptional regulatorC. glabrataPdr1 (CgPdr1). CgPdr1 induces the expression of an ATP-binding cassette (ABC) transporter-encoding gene, CgCDR1.Saccharomyces cerevisiaehas two CgPdr1 homologues called ScPdr1 and ScPdr3. These factors control the expression of an ABC transporter-encoding gene called ScPDR5, which encodes a homologue of CgCDR1. Loss of the mitochondrial genome (ρ0cell) or overexpression of the mitochondrial enzyme ScPsd1 induces ScPDR5expression in a strictly ScPdr3-dependent fashion. ScPdr3 requires the presence of a transcriptional Mediator subunit called Gal11 (Med15) to fully induce ScPDR5transcription in response to ρ0signaling. ScPdr1 does not respond to either ρ0signals or ScPsd1 overproduction. In this study, we employed transcriptional fusions between CgPdr1 target promoters, like CgCDR1, to demonstrate that CgPdr1 stimulates gene expression via binding to elements called pleiotropic drug response elements (PDREs). Deletion mapping and electrophoretic mobility shift assays demonstrated that a single PDRE in the CgCDR1promoter was capable of supporting ρ0-induced gene expression. Removal of one of the two ScGal11 homologues fromC. glabratacaused a major defect in drug-induced expression of CgCDR1but had a quantitatively minor effect on ρ0-stimulated transcription. These data demonstrate that CgPdr1 appears to combine features of ScPdr1 and ScPdr3 to produce a transcription factor with chimeric regulatory properties.

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Mabkhot, Hashed. "Factors Affecting the Sustainability of Halal Product Performance: Malaysian Evidence." Sustainability 15, no. 3 (January 18, 2023): 1850. http://dx.doi.org/10.3390/su15031850.

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The purpose of this research is to examine the impact of supply chain integration (SCI), demand for halal products (DHP), halal marketing (HM), process quality improvement (PQI), food safety concerns (FSCs), and health consciousness (HC) on sustainable product performance (SPP) in the halal food industry in Malaysia. A survey was conducted with 212 respondents from Malaysian halal-certified companies, and the partial least squares (PLS-SEM) method was used for the data analysis. The findings indicate a positive and significant link between SCPI, HC, PQI, and SPP. In contrast, the findings show no significant link between HM, FSC, and SPP. DHP was found to have a negative, non-significant association with SPP. This paper concludes by discussing the implications of the findings and opportunities for future research.

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Siebert, Joseph R., Bryan Williams, Darin Collins, Linda A. Winkler, and Daris R. Swindler. "Spontaneous Cleft Palate in a Newborn Gorilla (Gorilla gorilla gorilla)." Cleft Palate-Craniofacial Journal 35, no. 5 (September 1998): 436–41. http://dx.doi.org/10.1597/1545-1569(1998)035<0436:scpian>2.3.co;2.

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Iosue, Christine L., Julia M. Ugras, Yakendra Bajgain, Cory A. Dottor, Peyton L. Stauffer, Rachael A. Hopkins, Emma C. Lang, and Dennis D. Wykoff. "Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata." PLOS ONE 18, no. 6 (June 7, 2023): e0286744. http://dx.doi.org/10.1371/journal.pone.0286744.

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Understanding metabolism in the pathogen Candida glabrata is key to identifying new targets for antifungals. The thiamine biosynthetic (THI) pathway is partially defective in C. glabrata, but the transcription factor CgPdc2 upregulates some thiamine biosynthetic and transport genes. One of these genes encodes a recently evolved thiamine pyrophosphatase (CgPMU3) that is critical for accessing external thiamine. Here, we demonstrate that CgPdc2 primarily regulates THI genes. In Saccharomyces cerevisiae, Pdc2 regulates both THI and pyruvate decarboxylase (PDC) genes, with PDC proteins being a major thiamine sink. Deletion of PDC2 is lethal in S. cerevisiae in standard growth conditions, but not in C. glabrata. We uncover cryptic cis elements in C. glabrata PDC promoters that still allow for regulation by ScPdc2, even when that regulation is not apparent in C. glabrata. C. glabrata lacks Thi2, and it is likely that inclusion of Thi2 into transcriptional regulation in S. cerevisiae allows for a more complex regulation pattern and regulation of THI and PDC genes. We present evidence that Pdc2 functions independent of Thi2 and Thi3 in both species. The C-terminal activation domain of Pdc2 is intrinsically disordered and critical for species differences. Truncation of the disordered domains leads to a gradual loss of activity. Through a series of cross species complementation assays of transcription, we suggest that there are multiple Pdc2-containing complexes, and C. glabrata appears to have the simplest requirement set for THI genes, except for CgPMU3. CgPMU3 has different cis requirements, but still requires Pdc2 and Thi3 to be upregulated by thiamine starvation. We identify the minimal region sufficient for thiamine regulation in CgTHI20, CgPMU3, and ScPDC5 promoters. Defining the cis and trans requirements for THI promoters should lead to an understanding of how to interrupt their upregulation and provide targets in metabolism for antifungals.

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ARONSON, RONNIE, AIHUA LI, RUTH E. BROWN, NAOMI ORZECH, ASHLEY LYONS, and ASHLEIGH WALKER. "684-P: Assessment of Individual Self-Management Using the Novel LMC Skills, Confidence, and Preparedness Index (SCPI)." Diabetes 68, Supplement 1 (June 2019): 684—P. http://dx.doi.org/10.2337/db19-684-p.

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Mohammad, Ali Ameen, Bashar Alwannos, and Alaa Salman. "Automated Gain Measurement System for Wide-Band Antenna Based on Instruments Remote Access Techniques: Direct SCPI Commands." Pakistan Journal of Engineering and Technology 7, no. 2 (July 23, 2024): 72–78. http://dx.doi.org/10.51846/vol7iss2pp72-78.

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A novel approach to wide-band antenna gain measurement is presented in this article, offering practical solutions to address the challenges posed by traditional measurement methods. The proposed system enhances efficiency, reduces complexity, and improves accuracy, making it a valuable tool for antenna testing in research and industry settings. A discussion of the challenges and complexities involved in measuring the specifications of manufactured antennas is made. We are particularly focusing on wide-band antenna gain measurement. It highlights the need for special equipment and expertise to conduct these tests effectively, especially for wide-band antennas. The proposed automated measurement system aims to simplify and streamline the gain measurement process by remotely driving the necessary instruments and reducing the complexity of the measurement mechanism. The novelty of this new automated measurement system can be divided into two branches. The first branch improves the standard approach of wide-band antenna gain measurement. The second branch modifies the structure of the software of the traditional remote access applications by mixing the operational instructions of the instrument with the direct SCPI commands. The resulting software has the ability to remotely drive many instruments synchronically, reducing the number of experienced people needed to complete the measurement process.

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Majebi, Oluyemisi I., M. T. Oni, Gladys T. Segun-Dipe, S. K. Babarinde, and Esther A. Oduolowu. "Effectiveness of Socio-Constructive Collaboration Strategy on Post-Covid Primary School Children’s Learning Outcome in National Values." International Journal of Research and Innovation in Social Science VIII, IIIS (2024): 1705–14. http://dx.doi.org/10.47772/ijriss.2024.803122s.

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This study adopted socio-constructive collaboration strategy to enhance pupils’ learning outcome (social and cognitive skills) in national values after resumption from the compulsory closure of school for 6months. Quasi-experimental design was employed. Three hypotheses were raised and tested at 0.05 level of significance. 480 Primary one pupils from four public primary schools assigned to experimental and control within two local governments across four states participated in the study. The research spanned 15weeks. Validated instruments; Primary Pupils’ Achievement Test in National Values (PPATNV) and the Primary Pupils’ Social Skills Rating Scale (PPSSRC) were used to measure outcomes. Additionally, a Socio-constructive Pedagogical Instructional Guide (ScPIG) steered the delivery of the teaching and learning activities during the experiment. The study employed a statistical technique called analysis of covariance (ANCOVA) combined with a post-hoc test, especially the Bronfenbrenner test to analyse the pupils’ learning outcome. The results revealed significant positive effects of the intervention on both social skills and cognitive abilities (p<0.05) of pupils. Interestingly, school location also influences social skills. Furthermore, the intervention demonstrably improved students’ national values performance (p<0.05). The study concludes that a socio-constructivist collaborative teaching strategy significantly enhances pupils learning outcomes in areas related to social skills and cognitive development (national values comprehension). These findings suggest the potential benefits of adopting such strategies in primary school education for fostering well-rounded development in young learners

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Liu, Chang, Yi Fei Pei, and Jing Chuan Zhang. "The Thermal Simulation and Control Technology in Spacecraft Vacuum Thermal Test." Applied Mechanics and Materials 390 (August 2013): 696–702. http://dx.doi.org/10.4028/www.scientific.net/amm.390.696.

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The thermal simulation and control system is the core of vacuum thermal test of the spacecraft, which is used for tests design, data acquisition, thermal simulation and control, data management. In order to meet these application requirements, research contents and methods of keys techniques were expounded, which mainly includes three aspects: modeling analysis of test design workflow based on UML, architecture design and function design of test design software based on database and ASP; establishing universal driver function library based on VISA and SCPI, parallel driver design based on multithread technology; control mode and control algorithm design based on control objects requirements of the thermal simulation. Then the paper introduces the application of the research achievements, including test design software, data acquisition software, thermal simulation and control software. Finally, the paper prospects the main development direction of the thermal simulation and control technology along with the booming development of the China`s space industry.

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Journal articles on the topic 'Scpi85'

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