Dissertations / Theses: 'Science of life'

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Lam, Hoe-chung, and 林浩沖. "Hong Kong Life Science Museum." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B3198342X.

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Devine, Catherine. "Life Science For Elementary Teachers." UNF Digital Commons, 1990. http://digitalcommons.unf.edu/etd/169.

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Science is taught at all grade levels, yet there exists a deficiency in the amount of emphasis placed on science training for elementary teachers. As a result, teachers often feel inadequate in their knowledge of scientific areas and in their ability to develop science process skills in their students. As a result in this lack of training, a need exists to provide programs to increase skill and confidence of elementary teachers not only in teaching science concepts but science process skills as well. One means of meeting this need was the development of an activity-based, process-oriented inservice curriculum designed specifically for elementary science. The curriculum was designed as an inservice component of 60 hours that emphasized process skills as well as updating science concepts. The curriculum was designed for use in grades 1-6 and stressed "hands-on" experiences using readily available materials and a minimum of specialized equipment. The curriculum was field tested as a component of the Clay county, Florida Summer Inservice Institute. Thirty eight teachers, whose teaching assignments ranged from kindergarten to sixth grade, participated in the field test. At the beginning of the Institute, no participant scored 80% or better on a pretest of knowledge of concepts and process skills. Each participant completed each 'activity in the role of a student, including forming a hypothesis, collecting data, and drawing a conclusion. Activities were then discussed stressing process skills used and an indepth review of concepts involved. On the final day of the Institute, 84% of the participants scored 80% or better on the posttest. Furthermore, evaluations of the component by particiPants indicated a marked improvement in confidence in and enthusiasm for teaching science process skills. Overall the curriculum met the objective of increasing elementary teachers' ability and willingness to teach science process skills as well as science concepts.

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Lam, Hoe-chung. "Hong Kong Life Science Museum." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25956152.

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Thompson, Deborah R. "Life Science: An Outdoor Learning Approach." UNF Digital Commons, 1986. http://digitalcommons.unf.edu/etd/61.

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The instructional materials prepared for this project are based on outdoor activities that correlate with the Duval County, Florida, Performance Objectives for Life Science in the seventh grade. Special emphasis is placed on hands-on, sensory experiences and observations, and sequencing of instruction within lessons. The review of related literature includes the philosophy of outdoor/environmental education, a historical perspective of outdoor/environmental education, and learning theory as it applies to the principles and practices of an outdoor approach to education.

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Bergström, Sara. "Integrated Micro-Analytical Tools for Life Science." Doctoral thesis, Uppsala University, Analytical Chemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6049.

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Advances in life science require knowledge of active molecules in complex biological systems. These molecules are often only present for a certain time and at limited concentrations. Integrated micro-analytical tools for sampling, separation and mass spectrometric (MS) detection would meet these requests and are therefore continuously gaining interest. An on-line coupling of analytical functions provides shorter analysis time and less manual sample handling. In this thesis, improved compatibility of microdialysis sampling and multidimensional separations coupled to MS detection are developed and discussed.

Microdialysis was used in vitro for determination of the non-protein bound fraction of the drug ropivacaine. The sampling unit was coupled on-line to capillary column liquid chromatography (LC) followed by ultraviolet or MS detection. For MS detection, the system was extended with a desalting step and an addition of internal standard. A method for MS screening of microdialysates, collected in vivo, was also developed. The method involved sampling and measurements of the chemical pattern of molecules that generally are ignored in clinical investigations. Chemometric tools were used to extract the relevant information and to compare samples from stimulated and control tissues.

Complex samples often require separation in more than one dimension. On-line interfaces for sample transfer between LC and capillary electrophoresis (CE) were developed in soft poly(dimethylsiloxane) (PDMS). MS detection in the LC-CE system was optimised on frequent sampling of the CE peak or on high resolution in mass spectra using time-of-flight (TOF)MS or Fourier transform ion cyclotron resonance (FTICR)MS, respectively. Aspects on electrode positioning in the LC-CE interface led to development of an on-column CE electrode. A successful method for deactivation of the PDMS surface using a polyamine polymer was also developed. The systems were evaluated using peptides and proteins, molecules that are gaining increased attention in bioscience, and consequently also in chemical analysis.

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Ruston, Sharon. "P.B. Shelley and the science of life." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366974.

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Nilsson, Roland. "Statistical Feature Selection : With Applications in Life Science." Doctoral thesis, Linköping : Department of Physcis, Chemistry and Biology, Linköping University, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/tek1090s.pdf.

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Neumann, Sandra Brigitte. "E-commerce for consumables in the life science industry." [Zürich] : [s.n.], 2002. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=14779.

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Neumann, Sandra Brigitte. "E-commerce for consumables in the life science industry /." [S.l.] : [s.n.], 2001. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=14779.

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Sudirman, Azizahalhakim. "Increased Functionality of Optical Fibers for Life-Science Applications." Doctoral thesis, KTH, Kvantelektronik och -optik, QEO, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-145319.

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The objective of this thesis work is to increase the functionality of optical fibers for possible applications in life-sciences. Optical fibers are a promising technology for use in biology and medicine. They are low-costwaveguides, flexible and have a small cross-section. They can guide high-power light with low loss in a micrometer core-size. These features make fibers attractive for minimally-invasive,in-vivostudies. The backwards guidance of the optical signal allows for real-time monitoring of the distance to the scattering targets and to study the environment through Raman scattering and fluorescence excitation. The longitudinal holes introduced in the fibers can be used,for instance,for delivery of medicine to a specific regionof a body. They could even be used for the extractionof species considered interesting for further analysis, for example, studyingcells that may be cancer-related. This thesis deals with four main topics. First, a demonstration is presented of the combination of high-power light guidance for ablation, low-power light reflectometry for positioning, and for liquid retrieval in a single fiber. It was found that in order to exploit the microfluidic possibilities available in optical fibers with holes, one needs to be able to combine fluids and light in a fiber without hindering the low-loss light guidance and the fluid flow. Secondly, one should also be able to couple light into the liquids and backout again. This is the subject of another paper in the present thesis. It was also observed that laser excitation through a fiber for the collection of a low-intensity fluorescence signal was often affected by the luminescence noise createdby the primary-coating of the fiber. This problem makes it difficult to measure low light-levels, for example, from single-cells. Athirdpaper in this thesis then describes a novel approach to reduce the luminescence from the polymer coating of the fiber, with the use of a nanometer-thick carbon layer on the cladding surface. Finally, exploiting some of the results described earlier, an optical fiber with longitudinal holes is used for the excitation, identification and for the collection of particles considered being of interest. The excitation light is guided in the fiber, the identification is performed by choosing the fluorescent particles with the appropriate wavelength, and, when a particle of interest is sufficiently near the fiber-tip, the suction system is activated for collection of the particle with good specificity. It is believed that the work described in this thesis could open the doors for applications in life-sciences and the future use of optical fibers for in-vivo studies.

QC 20140516

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Yuan, Liang. "Sensing and Automation for Protein Studies in Life Science." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1311803164.

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Lippe, Anka [Verfasser], Jens [Akademischer Betreuer] Christoffers, and Karl-Wilhelm [Akademischer Betreuer] Koch. "Diaminoterephthalsäurederivate: Fluoreszenzfarbstoffe für die Life Sciences und Materials Science / Anka Lippe ; Jens Christoffers, Karl-Wilhelm Koch." Oldenburg : BIS der Universität Oldenburg, 2019. http://d-nb.info/1200547330/34.

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King, Loren A. (Loren Antony) 1968. "Democracy and city life." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8241.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Political Science, 2001.
Includes bibliographical references (p. 187-204).
The deliberative turn in recent political theory ties legitimacy to public deliberation about reasons, offered for and against exercises of authority by informed and sincere citizens, who share a commitment to finding mutually acceptable terms of social cooperation. But even such reasonable citizens may disagree on important matters, and some citizens will only rarely, if ever, see their sincere reasoned judgements reflected in democratic outcomes. I argue that, to be widely perceived as legitimate in plural settings, fair deliberative procedures must not only be inclusive and self-evidently grounded in a commitment to reasonableness and mutual respect; they must further ensure that dissenting parties have a reasonable expectation of eventually transforming features of the public sphere to better accommodate their distinctive values and interests. The result is a fair deliberative pluralism that reflects the cacophonous and variegated character of the public sphere in modern democracies. But I caution that this ideal requires conditions that can sustain spatial patterns of wealth and control over land uses that undermine the interests of certain spatially fixed groups. I draw on the experiences of U.S. cities to illustrate this tension. These cities feature profound and enduring inequalities of wealth and political influence, and urbanization generates patterns of industry and habitat that reinforce these inequalities. Municipal and state politics rarely alter the prevailing incentives for home and industry location that perpetuate these patterns,
(cont.) and when efforts are made to do so - for instance, urban growth boundaries, or new taxation schemes to fund public services - the result is often increased antagonism between central cities and their regions. I suggest that these problematic features of cities emerge from political processes that determine how urban spaces are valued, resulting in boundaries and behaviors that undermine the democratic credentials of much political activity in urban settings. I evaluate two classes of solutions to these urban pathologies in light of class-specific constraints on mobility that originate in political strategies of control over urban spaces.
by Loren A. King.
Ph.D.

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Cheney, David W. "Information technology, science, and public policy." Fairfax, VA : George Mason University, 2007. http://hdl.handle.net/1920/2959.

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Thesis (Ph. D.)--George Mason University, 2007.
Title from PDF t.p. (viewed Jan. 17, 2008). Thesis director: Don E. Kash Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Public Policy. Vita: p. 330. Includes bibliographical references (p. 289-329). Also available in print.

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Govett, A., and Alison L. Barton. "Bringing Science of Mind to [Science] Educators: Mindfulness in the Science Classroom." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/3425.

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Lazarevic, David. "Life Cycle Thinking and Waste Policy : Between Science and Society." Doctoral thesis, KTH, Industriell ekologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-105781.

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This study investigates the application of life cycle thinking (LCT) and life cycle assessment (LCA) in the field of waste management from perspectives based in the social sciences. LCT is explored through the theoretical construct of regimes, drawing theoretical resources from a combination of the ‘pragmatic turn’, the economics of conventions and transition theory.This work is based on eight papers treating theoretical arguments, qualitative and quantitative analysis, case studies and semi-structured interview data. LCT is placed in the context of contemporary societies. LCA is seen as an instrument of quantification and evaluation used by actors which have both similar and disparate objectives, and who offer justifications for its use through arguments embedded in conflicting pluralities of worth. Furthermore, this work analyses LCA as a tool for the qualification of the waste hierarchy; a waste management principle articulating a convention based on closed material cycles. This study argues that the technological trajectory of waste management regimes has been significantly influenced, inter alia, by actors’ institutional articulation of the waste hierarchy at national and territorial levels. It discusses the legitimacy of LCA, and the quantitative application of LCT, as an intermediary object used to qualify the waste hierarchy. Furthermore, LCT is placed in a prospective context which may be used to assist in the transition toward sustainable waste management.

QC 20121127

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Tetlow, Philip David. "Investigations into Web science and the concept of Web life." Thesis, University of Sunderland, 2009. http://sure.sunderland.ac.uk/3555/.

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Our increasing ability to construct large and complex computer and information systems suggests that the classical manner in which such systems are understood and architected is inappropriate for the open and unstructured manner in which they are often used. With the appearance of mathematically complex and, more importantly, high scale, non-deterministic systems, such as the World Wide Web, there is a need to understand, construct and maintain systems in a world where their assembly and use may not be precisely predicted. In Addition, few have thus far attempted to study such Web-scale systems holistically so as to understand the implications of non-programmable characteristics, like emergence and evolution – a matter of particular relevance in the new field of Web Science. This collection of prior published works and their associated commentary hence brings together a number of themes focused on Web Science and its broader application in systems and software engineering. It primarily rests on materials presented in the book The Web’s Awake, first published in April 2007.

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Lazarevic, David Andrew. "Life cycle thinking and waste policy : between science and society." Troyes, 2012. http://www.theses.fr/2012TROY0037.

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Ce travail se penche sur les atouts et limites de la mise en oeuvre des principes du cycle de vie (LCT) et de l'analyse du cycle de vie (ACV) dans le domaine de la gestion des déchets à partir de perspectives propres aux sciences sociales. La LCT est explorée à travers la construction théorique des régimes conventionnels, s’appuyant sur un travail d’interface entre sociologie pragmatique et théorie de la perspective multi-niveaux des systèmes d'innovation. La LCT est analysée dans le contexte des sociétés contemporaines. La LCT et son pendant technique, l’ACV, sont représentés comme des instruments de quantification et d'évaluation utilisés par des acteurs dotés d’objectifs à la fois semblables et disparates. L’ACV devient alors un instrument de justification utilisé par des acteurs en univers controversé, dans la tentative d’objectiver les choix collectifs dans un sens favorable à leurs intérêts. En ce sens, cette thèse analyse l’ACV en tant qu’outil de qualification du principe de hiérarchisation du traitement des déchets, un principe en phase avec le principe conventionnel du bouclage des flux de matières. Nous faisons valoir que la trajectoire technologique des régimes nationaux de gestion des déchets en Europe est fortement influencée, inter alia, par les arrangements institutionnels entre acteurs à différentes échelles territoriales. Nous discutons de la légitimité de l’ACV en tant qu’objet intermédiaire utilisé pour qualifier la hiérarchie des modes de traitement des déchets
This study investigates the application of life cycle thinking (LCT) and life cycle assessment (LCA) in the field of waste management from perspectives based in the social sciences. LCT is explored through the theoretical construct of regimes, where theoretical resources drawn from the combination of the ‘pragmatic turn’ and the multi- level perspective of system innovation. This work is based on seven papers treating theoretical arguments, qualitative and quantitative analysis, case studies and semi-structured interview data. LCT is placed in the context of contemporary societies. LCT and LCA are seen as instruments of quantification and evaluation used by actors which have both similar and disparate objectives, and who offer justifications for its use through arguments embedded in conflicting pluralities of worth. Furthermore, this work analyses LCA as a tool for the qualification of the waste hierarchy; a waste management principle articulating the convention of closed material cycle economies. This study argues that the technological trajectory of waste management regimes has been significantly influenced, inter alia, by actors’ institutional articulation of the waste hierarchy at national and territorial levels. It discusses the legitimacy of the quantitative application LCT and LCA as intermediary objects used to qualify the waste hierarchy. Furthermore, LCT is placed in a prospective context which may be used to assist in the transition toward sustainable waste management

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Carr, John Leonard. "Leigh Brackett : American science fiction writer--her life and work /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1291223654.

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Dunlap, Sarah Elizabeth. "Novel Ecologies: The New Science of Life in Modern Fiction." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1494318892609889.

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Anderton, Dane. "Firm ecologies : life science and video game industries in Liverpool." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2009228/.

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This research examines the life science and video games industries in Liverpool. Previous research on agglomerations and cities tends to focus on epicentres or high concentration places such as Silicon Valley or global cities such as London and Tokyo, neglecting the northern post-industrial cities such as Liverpool, Leeds or Newcastle. Equally, many studies tend to focus in on one particular industry, whereas this research examines two key knowledge economy sectors in one place. Petilis (2012) argues that the cluster literature has become overemphasised and lacks analytical ability in the investigation of smaller firms and highly diverse concentrations of activity. An alternative ecological perspective is used in this thesis, which is considered more reflexive and flexible to the composition of the agglomerations seen outside the epicentres of the global economy. Using the heterarchical approach, as outlined by Grabher (2001), this research investigates the emergence and organisation of Liverpool’s life science and video game industries. It reveals the changing composition of the industries in Liverpool and how firms are connected into wider production networks beyond Liverpool. Finally, the research analyses how the two industries are situated in the anatomy of the city. The key findings are generated from a mixed methodology utilizing qualitative semi-structure interviews with owner-managers, industry informants and supporting institutions. Secondary quantitative data has been used gathered from annual reports, company websites, industry association and office for national statistics. Firstly, it is argued that the two industries emerged in Liverpool under different conditions and are on different trajectories, conditioned by local events and global mechanisms in the wider industry. Such trajectories have aided the rise or the fall of various structures and institutions within the city of Liverpool. This has resulted in a life science industry that resembles an institutionally thick anatomy and a video games industry that resembles an institutionally thin anatomy. Secondly, key findings regarding the organisation and connections beyond Liverpool highlight the fact that both industries show a lack of internal connectivity within the ecology and depend significantly on their external connections for inputs in production. For the life sciences this is exacerbated with the high level of product diversity between firms decreasing the likelihood of potential internal connectivity in production or joint resource utilization between firms. Thus firms rely on their external connections for finance and resources in order to further the production of their products through licensing and merger and acquisition agreements. Thirdly, the video games industry has gained greater autonomy over production analogues to that of the industry norm. For the life sciences, the rigidity in the generic business model is reinforced by the high levels of regulation and intellectual property protections and reduces the ability of some smaller firms to complete a product. Overall, we see two key knowledge economy sectors emerging with changing degrees of functionality as a result of global changes in the industry and the development of institutional infrastructures around these two sectors.

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Summerton, Ciaran. "Modern mathematical science and technology: Formalisation of the life world." Thesis, Summerton, Ciaran (2011) Modern mathematical science and technology: Formalisation of the life world. Honours thesis, Murdoch University, 2011. https://researchrepository.murdoch.edu.au/id/eprint/6295/.

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In this dissertation, I offer a critical examination of modern science with a particular stress on the changes that the modern scientific project inaugurated. The focus is how modern science has radically changed the way we think about the world. I draw upon several phenomenological thinkers who have considered the changing nature of modern science and its relation to our present day thinking. I begin by exploring the key differences between the Ancient Greek and modern scientific understanding of mathematics, geometry, and idealisation. Specifically, I discuss the reversal of Platonic geometry carried out by Galileo Galilei and the formalisation of Galilean physics achieved by Isaac Newton. In addition, I outline the key methodological features of modern science, which include indirect mathematisation and perfect causality, as well as the role of experimentation in the modern scientific project. Theory is central to modern science in its function of opening certain regions of things, while delimiting others. Thereby, I discuss how theory prescribes what counts as facts for science and experimentation, in advance. Finally, I consider the pervasiveness of instrumental reasoning in modern science and technology. I conclude with a discussion of the institutional setting of modern science and its participation in business, governance, and power relations in these domains.

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Grey, Carmody Teresa Sinclair. "Theology, science and life with John Milbank and Hans Jonas." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.743015.

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Ernstsson, Hampus, and Liljesvan Max Börjes. "Multiples for Valuation Estimates of Life Science Companies in Sweden." Thesis, KTH, Matematisk statistik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-254239.

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Market multiples are a common and simple tool for estimation of corporate value. It can express temporal dynamics and differences in markets, industries and firms. Despite their practical usefulness, some critical problems remains which continue to be debated. This thesis investigates if there exists characteristics for explaining market capitalization by market multiples within the life science industry in Sweden. The approach follows well known theory of multiple linear regression analysis. The results indicated only a linear relationship between the market cap and the R\&D expenditures of a company. This does not mean that the other explanatory variables does not have effect on market cap only that there is no linear relationship that could be statistically proven.
Värderingsmultiplar är ett vanligt och enkelt verktyg för att approximera företags värde. Det kan beskriva temporär dynamik och skillnader hos marknader, industrier och bolag. Trots dess praktiska användbarhet finns en del kritiska problem som fortfarande debatteras. Denna uppsats undersöker om det existerar några egenskaper för att förklara marknadsvärdet med hjälp av värderingsmultiplar inom life science industrin i Sverige. Tillvägagångssättet följer välkänd teori om multipel linjär regressions analys. Resultaten visade att det endast finns ett samband mellan marknadsvärdet och utgifter för forskning och utveckling för ett bolag. Detta innebär inte att de andra variablerna inte har någon effekt på marknadsvärdet, utan att det inte finns ett linjärt samband som kan bevisas på ett statistiskt vis.

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STOLLFUSS, CARSTEN. "Electronic speckle pattern interferometry for vitality tests in life science." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/203013.

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This thesis focuses on the vitality analysis of single cells with the help of an optical measurement system. The Electronic Speckle Pattern Interferometry (ESPI) is an optical measurement method utilising an illuminated optical surface to create a Speckle or Speckle Pattern from a monochromatic light source. A Speckle Pattern is unique to its emitted surface and therefore rich on information about the surface. In addition, it can be used to analyse and classify microscopic specimen and even microscopic biological samples like cells. Its use to classify biological cells is still at a basic stage of research and many questions are still to be answered. This thesis focuses on the development of such a Micro-ESPI optical measurement system as well as on it’s application on biological cells in terms of the analysis and classification of cell vitality related to cell surface, cell death and general cell movement. Such Mico-ESPI device allows a new kind of non-invasive and non-destructive experimental approach towards the investigation of microscopic biological (cell) samples under real life conditions in aqueous solutions at highest magnifications up to 1000x.

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Nicolau, Daniela E. "Knowledge production and transfer in physical and life sciences /." Access via Murdoch University Digital Theses Project, 2002. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20061122.141122.

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Hoy, Sarida Peguero. "To Iron or to do Science: A Storied Life of a Latina from Scientist to Science Teacher." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/msit_diss/58.

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Reform initiatives such as Science for All Americans (AAA, 1989) and National Science Education Standards (NRC, 1996) argue for making science accessible to all children regardless of age, sex, cultural and/or ethic background, and disabilities. One of the most popular and prevailing phrases highlighting science education reform in the last decade has been science for all. In terms of making science accessible to all, science educators argue that one role of science teachers ought to be to embrace students’ experiences outside of the science classroom by becoming aware and inclusive of the cultural resources that student’s households contain. Moll, González and Amanti (1992) termed these cultural resources as funds of knowledge which refer to culturally developed bodies of knowledge and skills essential for household well being. This study examined the career transition of a former Latina scientist from a research scientist to a high school science teacher. Her lived experiences that influenced her career transition were examined using interpretive biography through a feminist theory lens. The following question guided the study: How have the lived experiences of the participant as engaged through cultural, historical, and social interactions influenced a transition in career from a research scientist to a classroom teacher? A former Latina scientist and her family participated in this study to facilitate the documentation, narration, and interpretation of her career transition. The researcher immersed herself in the field for five months and data collection included in-depth interviews with the participant and her family. In addition, the researcher kept a reflexive journal. Data were analyzed using socio-cultural thematic approach to identify snapshots and to develop emergent themes. Data analysis revealed that the participant’s cultural socialization conflicted with the Eurocentric/Androcentric culture of science found in both the university and research laboratories. Consequently the participant’s strong need to have a family was a powerful contributor to her selection of teaching as a second career. The participant’s lived experiences emphasized a need to explore the impact and interaction of ethnicity and gender in the myopic science culture that has left women and people of other cultures at the doorsteps of the scientific enterprise.

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Bergman, Laurila Jonas. "Ontology Slice Generation and Alignment for Enhanced Life Science Literature Search." Thesis, Linköping University, Linköping University, Linköping University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16440.

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Query composition is an often complicated and cumbersome task for persons performing a literature search. This thesis is part of a project which aims to present possible queries to the user in form of natural language expressions. The thesis presents methods of ontology slice generation. Slices are parts of ontologies connecting two concepts along all possible paths between them. Those slices hence represent all relevant queries connecting the concepts and the paths can in a later step be translated into natural language expressions. Methods of slice alignment, connecting slices that originate from different ontologies, are also presented. The thesis concludes with some example scenarios and comparisons to related work.

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Hedin, Erik. "Internationalisering inom life science : Fallstudier av Uppsalaföretagen Biotage, Olink och Orexo." Thesis, Uppsala University, Department of Business Studies, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110551.

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Life science sysselsätter i Uppsala 4500 personer varav 60% arbetar på de fyra största företagen. Branschen är forskningsintensiv och producerar bland annat läkemedel och produkter till läkemedelsbolag och akademiska institutioner. Produkterna är nischade och företagen måste ofta vara globala redan från start. Denna studie undersöker med hjälp av teorier om internationalisering tre fallföretag inom life science från Uppsala. Genom intervjuer och årsrapporter dras slutsatsen att fallföretagen främst har internationaliserat sin försäljning med olika strategier för att penetrera internationella marknader. Gemensamt för samtliga företag är att den personliga erfarenheten inom internationaliseringar anses mycket viktig, vare sig man använder sig av egna försäljningsorganisationer, agenter eller konsulter. Ingen strategi för internationell försäljning föredras framför den andra utan vilken strategi som används är olika från marknad till marknad och från produkt till produkt. Att vara nära kunderna med egna försäljningsorganisationer är särskilt viktigt då kunderna är läkemedelsbolag och akademiska institutioner, eftersom det ger möjlighet till återkoppling från dessa. Därigenom får man information om vilka produkter dessa efterfrågar. För läkemedelsbolag tycks det inte lika viktigt eftersom deras produkt genomgått ingående tester innan de lanseras. Egna försäljningsorganisationer är dock dyrt varför andra strategier också väljs. Enbart det största företaget Biotage har egna säljorganisationer på flera marknader.

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Harsanyi, Antal. "Elemental fluorine for the greener synthesis of life-science building blocks." Thesis, Durham University, 2016. http://etheses.dur.ac.uk/11705/.

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Fluorinated organic compounds are increasingly important in many areas of our modern lives, especially in pharmaceutical and agrochemical applications where the incorporation of this element can have a major influence on biochemical properties. The introduction of the carbon-fluorine bond into such systems is typically carried out using well established multistep, nucleophilic fluorination processes that usually lead to large waste streams. Despite the availability of alternative electrophilic fluorination methods which have found several applications on discovery scale, the direct transformation of C-H to C-F bonds on large scale is scarce. Elemental fluorine is the only electrophilic fluorinating reagent that is viable for manufacturing scale applications, but, in spite of the advances in this field in the past 25 years, there are only a handful of processes where it is used, most notably in the manufacturing of 5-fluorouracil. In this thesis the direct fluorination of several industrially relevant organic systems was investigated with an aim to provide optimised, high yielding and scalable processes that could be compared with existing manufacturing methods using a green chemistry metrics package developed by the EU IMI Chem21 consortium.

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Briggle, Adam. "The President's Council on Bioethics: Science, democracy, and the good life." Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3239376.

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32

Bezuidenhout, Louise Martha. "Contextuality in life science ethics : dual-use as a case study." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/12122.

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In the rapidly advancing field of the life sciences, issues relating to responsibility for research are becoming a key area of discussion. Attempting to conceptualise how individual and collective responsibilities may be attributed to scientists for their research is proving both difficult and complex. Issues relating to responsibility for research may be loosely divided into two different areas. Internal responsibilities refer to those that scientists hold to their research and their colleagues to ensure that high quality data is produced with integrity. Broad social responsibilities, in contrast, reflect the social contract that scientists hold with society and refer to the commitment of scientific research to enhance and promote humanity in a manner that takes into consideration social priorities and norms. By far, research on internal responsibilities has formed the bulk of current discussions on responsibility in life science ethics. These responsibilities have come to be represented by the field of research ethics, which focuses on the prevention of misconduct and the promotion of globally harmonised approaches to daily conduct. Research ethics has been widely endorsed, and a high level of international agreement has resulted in country-specific approaches to awareness raising and pedagogy – such as the Responsible Conduct of Research approach developed in the USA – being applicable for use in divergent social contexts. In contrast, however, broad social issues have received comparatively less attention from the life science ethics community. Indeed, these topics often do not have a place in ethics curricula, or form “add-on” topics to ethics modules. This thesis suggests that presenting broad social issues as a progression of research ethics topics may cause considerable difficulties for pedagogy. In particular, this thesis suggests that these problems arise through the promotion of an internationally harmonised approach to research ethics, the focus on avoiding misconduct, and the reliance on informal teaching within laboratories as a fundamental aspect of perpetuating research ethics. This thesis suggests that the crucial issue of contextual variations within ethics discussions is often marginalised. I argue such variations may have considerable implications for how scientists engage with notions of professional responsibility. Such points are particularly salient when noting that many scientists in developing countries are introduced to these topics through Western-centric ethics modules that do not take into account social, regulatory and physical variations in research environments in these countries. In order to critically interrogate contextual variations and social responsibility, the thesis makes use of an interdisciplinary approach, using a variety of methods of investigation. The topic of dual-use – the potential for beneficial research to be misused by third parties for nefarious means – was taken as a focalising example of a broad social issue and formed the basis of comparative investigations with scientists in sub-Saharan Africa and the UK. The fieldwork results showed significant variations between how scientists in developing countries and developed countries interacted with the topic of dual-use. It became clear that the Western-centric approach promoted by most current dual-use awareness raising initiatives, and the implicit research ethics teaching approaches in these models, caused considerable difficulties for African scientists attempting to access these discussions. Using the theoretical framework outlined at the beginning of the thesis and the fieldwork, the thesis concludes by proposing a number of changes that could be made to the way that broad social issues are presented to scientists within ethics pedagogy.

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Gripenstedt, Daniel, and Joakim Öberg. "A security analysis in a life science environment : a case study." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-299357.

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The cyber-threat against life-science is much larger today than just a couple of years back. Companies within the field have valuable information from example R& Din pharmaceuticals, biotech, personal data of vulnerable patients or medical devices and that is something attackers are very much aware of. Lab equipment have generally been disconnected from the internet to protect their data even more but the benefits a company would gain in diagnostics and support could outweigh it. In this paper a fictional environment with lab instruments, control units and databases is set up based on a real system used by Company X. A security analysis for the system is conducted with the goal to identify and analyse potential threats and risks. This was done by first study relevant literature along with meetings with representatives from Company X. The security analysis is made with a threat model called Yacraf which includes six different phases, the process was easy to follow and resulted in potential ways how an attacker could gain access to the system. The results also show different protection scenarios for these attacks and how Company X could implement preventive measures in advance. If Company X where to implement such a remote control system a first step would be to educate the employees to recognize common cyber-threats and only set up the remote connection when needed.
Cyberhotet mot life science är mycket större idag än för bara ett par år tillbaka. Företag sitter på värdefull information från exempel forskning och utveckling inom läkemedel, bioteknik, personuppgifter om utsatta patienter eller medicintekniska produkter och det är något som hackare är mycket medvetna om. Labutrustning har i allmänhet kopplats bort från internet för att skydda deras data ännu mer, men fördelar företag kan vinna på diagnistik och support skulle kunna uppväga det. I denna uppsats skapas en fiktiv miljö med laboratorieinstrument, styrenheter och databaser baserat på ett verkligt system som används av företag X. En säkerhetsanalys för systemet genomförs med målet att identifiera och analysera potentiella hot och risker. Detta gjordes genom att först studera relevant litteratur tillsammans med möten med företrädare för företag X. Säkerhetsanalysen är gjord med en hotmodell som heter Yacraf som innehåller sex olika faser, processen var lätt att följa och resulterade i potentiella sätt hur en angripare kunde vinna tillgång till systemet. Resultaten visar också olika skyddsscenarier för dessa attacker och hur Company X kunde genomföra förebyggande åtgärder i förväg. Om företag X skulle implementera ett sådant fjärrkontrollsystem skulle ett första steg vara att utbilda de anställda att känna igen vanliga cyberhot och bara ansluta fjärranslutningen vid behov.

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34

Deveci, Cem Carleton University Dissertation Political Science. "The Good life, science and politics in three early modern Utopias." Ottawa, 1996.

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35

Nkrumah, Tara M. "Weaved Journeys: Life Writings of Leading and Engagement in Science Education." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7872.

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This study’s purpose was to explore science engagement and in/equity through science educators’ narratives of servant leadership at both the K-12 and higher education levels in the United States. The research question was: How have participants become and led others to become engaged in science? I took an arts-based approach using drawings and autobiographical data to initiate and create metissages focused on becoming engaged in science education. The findings were that: (1) Participants helped marginalized students understand the culture of science through pedagogical strategies that connected self and science; (2) Participants recognized and countered systemic forms of oppression for students who are marginalized in science education through outreach in STEM; and (3) Participants offset disengagement in science among underserved groups through meaningful relationships and presented non-dominant examples of scientific inquiry. I discuss their implications for professional development and provide recommendations for future research concerning leadership/followership aimed at promoting science equity.

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Glausser, Anne O. (Anne O'Brien). "The placenta's second life." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/54572.

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Thesis (S.M. in Science Writing)--Massachusetts Institute of Technology, Dept. of Humanities, Graduate Program in Science Writing, 2009.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 37-42).
This thesis, written for a popular audience, explores the many facets of the placenta, an organ that facilitates the growth of the fetus during pregnancy. It looks at what happens when the placenta dodges the hospital incinerator-taking on a second purpose, a second life. Once the placenta is expelled during the third stage of labor, once it has served its role in the body and is facing retirement, it can take on whole new forms of usefulness. Humans, artful at manipulating the materials of life, have created new-and often controversial-purposes for this discard tissue after it has served its primary role: expelled placenta is used in eye surgery, in training dogs to sniff dead bodies, in toxicology research, in forensics, in cosmetics, and, most significantly, in an emerging field of stem cell research. From ritual use to research subject to health treatment, we have taken the placenta from the realm of the dead and given it new vigor.
by Anne O. Glausser.
S.M.in Science Writing

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37

Nadrowski, Karin, Daniel Seifarth, Sophia Ratcliffe, Christian Wirth, and Lutz Maicher. "Identifiers in e-Science platforms for the ecological sciences." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-101319.

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In the emerging Web of Data, publishing stable and unique identifiers promises great potential in using the web as common platform to discover and enrich data in the ecologic sciences. With our collaborative e-Science platform “BEFdata”, we generated and published unique identifiers for the data repository of the Biodiversity – Ecosystem Functioning Research Unit of the German Research Foundation (BEF-China; DFG: FOR 891). We linked part of the identifiers to two external data providers, thus creating a virtual common platform including several ecological repositories. We used the Global Biodiversity Facility (GBIF) as well the International Plant Name Index (IPNI) to enrich the data from our own field observations. We conclude in discussing other potential providers for identifiers for the ecological research domain. We demonstrate the ease of making use of existing decentralized and unsupervised identifiers for a data repository, which opens new avenues to collaborative data discovery for learning, teaching, and research in ecology.

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Nilsson, Stefan Kristoffer, and Peter Widding. "Life Science Boundary Spanners and Their Role in Exchange Processes with Academia." Thesis, Umeå University, Umeå School of Business, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-24545.

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Innovation and entrepreneurship are recognized by many scholars as two of the key factors in company, regional and ultimately national growth. Up until now scholars have focused on macro level research leading to theories such as different innovation systems which explain how society through legislation and other incentives can facilitate the collaboration process between e.g. industry and academy leading to innovation. Despite this interest in the innovation process little effort has been made to elucidate how collaboration and innovation occurs from an individual perspective. This process involves individuals that interact in a knowledge exchange process.

Boundary spanners have been identified as facilitators and drivers of innovative processes between organizations. Their extensive networks enable them to distinguish collaboration opportunities and win-win situations with outside partners. In most industries boundary spanners are quite uncommon but within the life science sector many employees are potential boundary spanners since they often have an academic background and thus a good network with a major collaboration partner. We decided to look into the life science industry in order to investigate the exchange process in innovation collaborations and the role of academic background among boundary spanners. The research question that has guided this thesis was set to;

what prominent exchange customs exist among these boundary spanners and what does the background of these individuals have for these exchanges?

To be able to answer our research question and fulfill our aim we have made a qualitative hermeneutical study. By using a pending approach between deduction and induction we have continuously created understanding during the process of our theoretical and empirical generation. By performing five in-depth interviews with representatives from three different life science organizations we investigated how collaboration processes with academia are built and what role academic background can have for the boundary spanners involved.

From our empirical findings we derived answers to meet our aim;"identify prominent exchange customs among boundary spanners in innovation processes between academic and industry partners."

Exchange customs were dependent on foremost networking procedures or procedures indirectly dependent in networks. The actions of searching, screening and signalling were found to be central in the innovation process and for exchange customs. Furthermore we answered two set of sub-purposes;(i) what role does academic background have for the development of exchange customs and procedures pursued by boundary spanners in industry?

and(ii) how can background knowledge of academia contribute to or mitigate exchanges between boundary spanners in industry and academia?

The role of academic background was found to contribute significantly to all network dependent activities such as the above mentioned exchange customs. Moreover, we identified the process of academic self contact, i.e. when academia approaches industry with ideas, which could be a direct effect from signalling processes or personal networks. Background knowledge about academia affects exchange customs since it creates a better understanding of the academic partners' needs.

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39

Richter, Claudia [Verfasser]. "Fertigungsmethoden zur Herstellung dreidimensionaler metallischer Mikrosysteme für Life-Science Anwendungen / Claudia Richter." Aachen : Shaker, 2015. http://d-nb.info/1080763511/34.

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40

Bremus-Köbberling, Elke Auguste. "Strukturierung und Modifizierung von Polymeren mit UV-Laserstrahlung für Life-science-Anwendungen." Aachen : Mainz, 2004. http://deposit.d-nb.de/cgi-bin/dokserv?idn=972730087.

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41

Mühlberger, Holger. "Mikrofluidische CE-Systeme aus Polymeren mit elektrischer Detektion für Life-Science-Anwendungen." Karlsruhe Forschungszentrum Karlsruhe, 2007. http://d-nb.info/985034475/34.

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42

Murad, Ahmad Najib Dato. "Novel life science technology business model : strategic issues in stem cells commercialisation." Thesis, Glasgow Caledonian University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547418.

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This study focused on stem cells research to better understand strategic issues of business models involved in technology commercialisation of novel life science technology. The research questions of this study can thus be defined as: (l) what strategy or business model is appropriate for stem cells research commercialisation? and (2) which theoretical issues impact on the selection of strategies which are appropriate for the commercialisation of novel technologies, specifically novel life science technology such as stem cells research. Three objectives were derived from the important question of how to commercialise technology and of particular interest to this study, novel technology such as stem cells research, to: (1) understand the extent and nature of uncertainties affecting stem cells research into routine therapeutic practice; (2) examine the effect of economic, political and ethical issues on the adoption and implementation of commercialisation strategy for stem cells research; and (3) determine possible strategies for survival and growth of biotechnology firms focusing on stem cells research. Fieldwork as carried out in Scotland where purposive sampling used led to the selection of five interviewees for the first round of interviews. Snowballing technique increased the number of interviewees to 12 in the second round of interviewees. The interviewees were essentially key actors in the Scottish stem cells community who possessed the relevant scientific, ethics, regulatory as well business and industry knowledge of stem cells research. The interviews were open-ended. A review of major broadsheet newspapers from the US and UK were also conducted as an exploratory study to address the balance of this study by incorporating an element of how policy issues related to science and technology controversy are defmed, symbolised and resolved. Interview data were transcribed and analysed using content analsysis software QSR NvivoFindings from both rounds of interviews indicated the importance of collaborative strategy such as strategic alliances in overcoming strategic issues of stem cells commercialisation. More government support for stem cells research appeared to be needed to overcome funding issues. The inclusion of newspaper review in the study indicated the positive reporting of stem cells in the UK compared to us. The contribution of findings from the newspaper article analysis establishes a link between public understandings of new technology that were not captured through the two rounds of interviews It is suggested that strategic alliances should be given consideration in future stem cells business model and commercialisation strategy research efforts. Ethical risk too should be part of this suggested model. The implications of these results for theoretical along with practical implications of the fmdings were discussed and opportunities for future research provided

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McGarvey, Patrick Brian. "An investigation of alliances between western life-science therapeutic and Indian firms." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/55274.

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Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology; and, (S.M.)--Massachusetts Institute of Technology, Sloan School of Management, 2008.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 43-45).
Large pharmaceutical companies (Multinational Pharmaceutical Companies or MPCs) have struggled in recent years with the rapidly accelerating costs of drug-discovery research and development. These costs continue to rise while resulting in fewer drug leads. Several industries have realized significant cost savings by outsourcing operations to countries with low-cost labor like India and China. Several factors have traditionally kept MPCs from moving high value, patent-sensitive discovery operations to India despite these drastically lower labor costs. However recent improvements in the Indian patent system in response to WTO compliance have stimulated an increase in both domestic investment in innovative research and in deal making within the life science industry. Nonetheless, there are few systematic analyses of the quantity of deal making between international and domestic Indian firms. Based on our analysis, we conclude that MPCs are establishing alliances at a greater rate than Biotechnology-based firms. In addition, we find that the improvements in patent law have created the structures necessary to stimulate innovation-based life science companies to establish relationships with Indian firms that put their most important types of intellectual property at risk.
by Patrick Brian McGarvey.
S.M.

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44

Batra, Shaurya. "A case for developing life science real estate in New York City." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/108897.

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Thesis: S.M. in Real Estate Development, Massachusetts Institute of Technology, Program in Real Estate Development in conjunction with the Center for Real Estate, 2017.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 71-72).
New York City, arguably the world's financial capital and the world's biggest real estate market, and home to some of the finest medical and academic research centers houses a little over a million square feet of life science focused real estate. Despite tremendous academic research potential and financial wherewithal, the life science industry of the city is comparatively much smaller to other New York City industries. In addition, it is much smaller in comparison to life science industry in other parts of the country. This thesis investigates the New York City market as a possible location for developing life science focused real estate assets. As a first step, the research will focus on identifying and analyzing the key demand indicators to establishing the demand for life science focused real estate. Next, the thesis will focus on lab space as a real estate product to understand its main components and value drivers. Upon understanding the market and the product, the research will put forward possible strategies for developing lab buildings in the city. Further, in support of the development strategies the research will look to prove the financial feasibility of developing that life science real estate in the city. This would involve financial analysis and contrasting returns from life science assets against office assets. Lastly, through real options framework the study will go on to demonstrate the benefits of applying flexibility to real assets, while financially valuing this flexibility using the Monte Carlo analysis.
by Shaurya Batra.
S.M. in Real Estate Development

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45

Bell, Luke. "Rocket science : phytochemical, postharvest, shelf-life & sensory attributes of rocket species." Thesis, University of Reading, 2016. http://centaur.reading.ac.uk/69943/.

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Rocket species are increasing in popularity with consumers, and in the last ten years scientific interest has also increased due to the potential health benefits of consuming leaves. They are known for pungent and bitter taste components, and the chemical compounds largely responsible for these sensations are also health beneficial. These compounds are called isothiocyanates (ITCs), and they are ubiquitous in the plant family Brassicaceae. Precursor compounds called glucosinolates (GSLs) are converted to ITCs via the action of myrosinase enzyme. This thesis presents data relating to numerous aspects of rocket species, such as differences in GSLs and ITCs. Other phytochemical constituents (flavonols, volatile organic chemicals (VOCs), free amino acids, free sugars, polyatomic ion content, and organic acids) are explored to determine their impacts on human sensory perceptions and consumer acceptance. The data presented highlight significant differences between ‘wild’ accessions of rocket and commercially available varieties, in terms of flavonol and GSL content and sensory attributes. There is great potential to develop underutilised genetic resources in breeding programs, and through collaboration with a breeding company (Elsoms Seeds Ltd., Spalding, UK) and a commercial salad supplier (Bakkavör Group Ltd., Spalding, UK), several accessions were selected for detailed analyses. Analysis of VOC profiles further demonstrated the differences between the selected cultivars, and by combining these data with sensory and consumer studies, it was observed that the diversity of phytochemical components fundamentally underpins taste, flavour, and consumer acceptance. The same accessions of rocket were also tested under commercial growth, processing and storage conditions. It was hypothesised that this would negatively impact GSL and ITC content of leaves, but in fact increased concentrations up to five fold from the point of harvest in all accessions analysed. We also observed a previously undocumented link between GSL, ITC and free amino acid content with bacterial load.

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Gärdemalm, Niemi Matilda, Öhrling Sara Rydberg, and Emma Stam. "Establishment of Technical Life Science Consulting Services in a Local Government Market." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-384571.

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This master thesis evaluates the possibility for Semcon AB to establish a business within the public sector of Uppsala. The need and prerequisites for technical life science consultant services has been investigated by interviewing experts in their field. The study is explanatory and contributes with an understanding of the current situation and the outlook for consultants in in the public sector, with Region Uppsala as the targeted customer. The results show that the need for consultants lies within IT, logistics, medtech, and construction. A consultant should preferably have a combination of these competences. Another possibility is to aid the public sector with the difficulties in specifying the requirements of a procurement. There are different ways of establishing a business with Region Uppsala. Either by a framework agreement, as a subcontractor, or by innovation procurement. One aspect of successful collaboration between a consultant company and the public sector is the attitudes toward consultants. The result indicates generally positive attitudes. Despite this a concern of knowledge disappearing when the assignment is finished exists. Therefore, transparency as well as constant feedback and evaluation is highly important.

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47

Agostini, Matteo. "Surface-acoustic-wave based biosensors and microfluidic devices for Life-science applications." Doctoral thesis, Scuola Normale Superiore, 2018. http://hdl.handle.net/11384/85916.

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In 2015 over half of the total deaths worldwide were due to the top ten causes of mortality, as stated by the World Health Organization. Heart disease, cancer, and diabetes are particularly prominent, especially in developing countries. In the last decades a significant amount of effort has been made by the scientific community in order to address these pathologies, from both the screening and the treatment points of view. To date, early-detection seems to be one of the most effective strategies in reducing the mortality. By diagnosing one of these pathologies at very early stages, the survival rate can be significantly enhanced. For example, the 5-year survival rate of women with breast cancer is ⇡72% for stage III (before metastasis), ⇡93% for stage II and close to 100% for stage I and 0 (American Cancer Society data). Automated, cheap, and portable devices that can help in diagnosing these illnesses would be a breakthrough for life-science applications, particularly for point-of-care (PoC) purposes. These devices are the so-called lab-on-chips (LoCs). LoCs are chips with a small surface (mm2–cm2) that embed many operations that are usually performed by trained personnel in a centralized laboratory facility. These operations include centrifugation, reagent mixing, heating, particle separation, cell counting, analyte detection, amongst many others. By making use of innovative plastic materials, piezoelectric substrates and cleanroom facilities for fabrication, it is possible to realize these novel devices that can potentially fulfill all the requirements for early-detection and PoC. In this PhD thesis, I present my research on this topic. During my studies, I exploited two promising technologies for LoCs, namely surface acoustic wave (SAW) and surface plasmon resonance (SPR), through which I explored novel configurations for microfluidics and biosensing on nanostructured devices. I started studying the effects of SAWs on liquid droplets, with particular attention to the heating and mixing and how these phenomena could be exploited for treating biological samples. I investigated how SAWs affect cell cultures and how they can improve cell-proliferation by generating fluid motion inside standard Petri dishes. Then, I demonstrated a microfluidic SPR biosensor enhanced by the presence of SAW-induced fluid mixing. By means of the SAW-generated fluid recirculation, this device can detect analytes in a significantly reduced time. Next, I demonstrated two different SAW-based biosensors, a cantilever with a SAW-based readout and a SAW-resonator. The performance of both of them were suitable for biomedical assays. In particular, the SAW-resonator is promising in the light of cancer biomarker detection, as it is almost ten times more sensitive than similar commercially available sensing units. Finally, I moved towards the development of a full-SAW microfluidic platform for biosensing, combining SAW-microfluidics and SAWbiosensing. I further improved the SAW-resonator chip design by integrating multiplexing and microfluidic channels for liquid sample handling. I also developed custom-made software for fast and reliable data acquisition and post-processing. The experiments presented here are performed with artificial fluids: biotin-avidin was chosen for the biorecognition model, as it is well known to mimic the biomolecular processes of biomarkers detection. In final chapters I show and discuss experiments in the presence of biological noise (i.e., non-specific binding molecules) and evaluate the biosensor performance with samples more similar to body fluids. The studies I carried out are promising in the light of development of versatile, portable, and sensitive SAW-based LoC for early-detection of pathologies, and show enhanced performance in both detection of biomolecules and reduced detection times with respect to traditional methods.

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Gabbidon, Colette Michelle. "Party life : an examination of the branch life of the Communist Party of Great Britain between wars." Thesis, University of Sussex, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333502.

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Conner, Brett P. (Brett Page) 1975. "Contact fatigue : life prediction and palliatives." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/16866.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2002.
Includes bibliographical references (p. 125-135).
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Fretting fatigue is defined as damage resulting from small magnitude (0.5-50 microns) displacement between contacting bodies where at least one of the bodies has an applied bulk stress. The applicability and limits of a fracture mechanics based life prediction is explored. Comparisons are made against highly controlled experiments and less controlled but more realistic experiments using a novel dovetail attachment fixture. Surface engineering approaches are examined from a mechanics perspective. Using a new tool, depth sensing indentation, the mechanical properties of an aluminum bronze coating are determined. Fretting fatigue experiments are performed on specimens coated with aluminum bronze and on specimens treated with low plasticity burnishing. Low plasticity burnishing is a new method of introducing beneficial compressive residual stresses without significant cold work at the surface. A mechanics based approach to the selection of palliatives is addressed.
by Brett P. Conner.
Ph.D.

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Power, Lucy A. "e-Research in the life sciences : from invisible to virtual colleges." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:de32d659-8908-4ebe-ab50-3ba6330f456a.

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e-Research in the Life Sciences examines the use of online tools in the life sciences and finds that their use has significant impact, namely the formation of a Scientific/Intellectual Movement (SIM) (Frickel & Gross, 2005) complemented by a Computerisation Movement (CM) (Kling & Iacono, 1994) which is mobilising global electronic resources to form visible colleges of life science researchers, who are enrolling others and successfully promoting their open science goals via mainstream scientific literature. Those within this movement are also using these online tools to change their work practices, producing scientific knowledge in a highly networked and distributed group which has less regard for traditional institutional and disciplinary boundaries. This thesis, by combining ideas about SIMs and CMs, fills a gap in research that is typically confined to treating new tools as a part of scientific communication or in specialist areas like distributed collaboration but not in terms of broader changes in science. Case studies have been conducted for three types of online tools: the scientific social networking tool FriendFeed, open laboratory notebooks, and science blogs. Data have been collected from semi-structured interviews, and the online writings of research participants. The case studies of exemplary use by scientists of the web form a baseline for future studies in the area. Boundaries between formal and informal scholarly communication are now blurred. At the formal level, which peer-reviewed print journals continue, many academic publishers now also have online open access, frequently in advance of print publication. At the informal level, what used to be confined to water-cooler chat and the conference circuit is now also discussed on mailing lists, forums and blogs (Borgman, 2007). As these online tools generate new practices they have potential to affect future academic assessment and dissemination practices.

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Dissertations / Theses on the topic 'Science of life'

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