Journal articles on the topic 'Schizophrenia'
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1
Galant, Yves. "On the structure and essence of the so-called. exogenous and symptomatic schizophrenias." Kazan medical journal 29, no. 11-12 (January 12, 2022): 987. http://dx.doi.org/10.17816/kazmj90291.
Abstract:
Gilyarovsky tries to clarify the confused question about the structure and essence of the so-called exogenous and symptomatic schizophrenias." between "schizophrenic reaction *, exogenous schizophrenia" and schizophrenia as such, as opposed to Boomke, who considers schizophrenia as one of the forms of exogenous reactions.
2
Batel, P. "Addiction and schizophrenia." European Psychiatry 15, no. 2 (March 2000): 115–22. http://dx.doi.org/10.1016/s0924-9338(00)00203-0.
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SummaryEpidemiologic studies in the general population and those based on the clinical assessment of schizophrenic populations have revealed a high degree of overlap between schizophrenia and addictive disorders. The abuse of psychoactive substances (including alcohol) throughout life is so frequent (50%) that the possibility of a specific link inevitably arises. Various hypotheses have been suggested to explain the high co-morbidity between schizophrenia and addiction: 1) The social-environmental hypothesis has been developed but studies have provided poor evidence to validate it. 2) The possible shared biological vulnerability between schizophrenia and addictions led researchers to explore common genetic determinants and study the involvement of the dopaminergic and opioid systems in the aetiology of both schizophrenia and the abuse of and dependence on psychoactive drugs. 3) Finally, the theory of self-medication suggests that schizophrenics may be attempting to counter the deficit linked to their disorders by using the substances they take or their dependency-type behaviour to cope with their emotional problems. The clinical profile of schizophrenic addicts does seem to display some distinctive features, such as the high level of depressive co-morbidity, very high nicotine and alcohol dependence, with a very poor prognosis. These patients are difficult to manage; the possibility of pharmacologic interactions between the substances they are taking and neuroleptic medication calls for prudence, and their compliance is also poor. Addictive disorders in schizophrenics are currently a topic of active research intended to lead to identifying specific treatments. The early identification of addictive disorders in schizophrenics should make it possible to limit their development and improve the prognosis.
3
Pulver, Ann E., Kung-Yee Liang, C. Hendricks Brown, Paula Wolyniec, John McGrath, Lawrence Adler, Doreen Tam, William T. Carpenter, and Barton Childs. "Risk Factors in Schizophrenia." British Journal of Psychiatry 160, no. 1 (January 1992): 65–71. http://dx.doi.org/10.1192/bjp.160.1.65.
Abstract:
The risk for schizophrenia among first-degree relatives of schizophrenic probands obtained from an epidemiological sample using family history methods was examined to determine whether month of birth of the proband was associated with familial risk. The results of this study of the first-degree relatives of 106 female schizophrenics and 275 male schizophrenics suggested that the relatives of probands born in the months February to May had the highest risk, although the association between month of birth and familial risk among the male probands was present only for those relatives who had onset of schizophrenia before the age of 30.
4
Shrikhande, Satish, Steven R. Hirsch, J. C. Coleman, Michael A. Reveley, and R. Dayton. "Cytomegalovirus and Schizophrenia." British Journal of Psychiatry 146, no. 5 (May 1985): 503–6. http://dx.doi.org/10.1192/bjp.146.5.503.
Abstract:
SummaryCerebrospinal fluid (CSF) from 20 chronically hospitalised male schizophrenics and from 12 patients admitted with acute schizophrenia were examined for antibodies against cytomegalovirus. A sensitive and specific enzyme-immunoassay was used to detect IgG or I g M classes of antibodies in the CSF of the schizophrenic patients and often orthopaedic patients, who served as controls. No significant amounts of I g M antibody were found in the CSF of either group. A significant titre of IgG was found in only one of the 32 schizophrenics, an acute patient, but in four of the orthopaedic patients. The results do not support an association of cytomegalovirus infection with schizophrenia; if such an association occurs, it must be unusual.
5
Angermeyer, Matthias C., Jill M. Goldstein, and Ludwig Kuehn. "Gender differences in schizophrenia: rehospitalization and community survival." Psychological Medicine 19, no. 2 (May 1989): 365–82. http://dx.doi.org/10.1017/s0033291700012411.
Abstract:
SynopsisThis study tested the hypothesis that schizophrenic men experience a poorer course than schizophrenic women. A representative sample from Hannover, FRG, including 278 first admission DSM-III schizophrenics, were followed for three years. Findings demonstrated that schizophrenic women experience fewer rehospitalizations, shorter lengths of stay, and survive longer in the community than schizophrenic men. Implications of the role of gender for schizophrenia are discussed.
6
Parnas, Josef, and Aage Jørgensen. "Pre-morbid Psychopathology in Schizophrenia Spectrum." British Journal of Psychiatry 155, no. 05 (November 1989): 623–27. http://dx.doi.org/10.1192/s0007125000018109.
Abstract:
In a prospective, longitudinal study of high-risk offspring of schizophrenic mothers, of several dimensions of pre-morbid behaviour ‘peculiarity’ predicted subsequent schizophrenia or schizotypy. Peculiarity/eccentricity may represent a subtle marker of the schizophrenic genotype. ‘Pre-schizophrenics', as compared with ‘pre-schizotypes', were characterised by affective dyscontrol, reflected in less introverted and more disturbed behaviour.
7
Parnas, Josef, and Aage Jørgensen. "Pre-morbid Psychopathology in Schizophrenia Spectrum." British Journal of Psychiatry 155, no. 5 (November 1989): 623–27. http://dx.doi.org/10.1192/bjp.155.5.623.
Abstract:
In a prospective, longitudinal study of high-risk offspring of schizophrenic mothers, of several dimensions of pre-morbid behaviour ‘peculiarity’ predicted subsequent schizophrenia or schizotypy. Peculiarity/eccentricity may represent a subtle marker of the schizophrenic genotype. ‘Pre-schizophrenics', as compared with ‘pre-schizotypes', were characterised by affective dyscontrol, reflected in less introverted and more disturbed behaviour.
8
Van Horn, J. D., and I. C. McManus. "Ventricular Enlargement in Schizophrenia." British Journal of Psychiatry 160, no. 5 (May 1992): 687–97. http://dx.doi.org/10.1192/bjp.160.5.687.
Abstract:
Multivariate meta-analysis was performed on 39 studies of ventricular size in schizophrenia which used the ventricle:brain ratio (VBR). The size of the VBR was dependent both upon the date when studies were carried out (more recent studies showing a reduction in the difference between schizophrenics and controls), and upon the diagnostic criterion used in the studies. Methodological factors in study design seemed more important than the characteristics of the schizophrenic subjects, in determining the VBR. Our analysis suggests that there is a difference in VBR between schizophrenics and controls which would seem to be an indisputable characteristic of schizophrenia. However, the difference is smaller than has previously been thought, so that, although of undoubted theoretical interest in accounting for the aetiology of schizophrenia, it is probably too small to be of practical significance in diagnosis, or in the differentiation of subtypes.
9
Hj. Fatmawati and Nurlina. "KARAKTERISTIK PENDERITA SKIZOFRENIA PADA PASIEN RAWAT JALAN DI POLIKLINIK JIWA RSUD H. ANDI SULTHAN DG. RADJA KABUPATEN BULUKUMBA." Jurnal Kesehatan Panrita Husada 3, no. 1 (August 4, 2019): 41–52. http://dx.doi.org/10.37362/jkph.v3i1.10.
Abstract:
Schizophrenia is a severe mental disorder that affects more than 21 million people worldwide. According to (Ministry of Health, 2013) the prevalence of severe mental disorders, such as schizophrenia, is 1.7 per 1000 residents or around 400,000 people. Schizophrenia is caused by multifactorial factors that are related to each other. The purpose of this study was to find out the factors associated with the incidence of mental disorders in H.AUD Hospital. Sulthan with Radja Bulukumba in 2018. This study uses Cross sectional design with a population of 554 people and a sample of 84 people. The sample used in this study is non probability sampling with purposive sampling technique. Based on statistical analysis using frequency distribution data The results of this study are based on the age of Schizophrenia sufferers more in adulthood, the sex of Schizophrenic patients is obtained by men as many as 40 people (50%), and women as many as 40 respondents (50%), Job Schizophrenia sufferers are more unemployed (82.5%) and those who work are 17.5%, the education level of Schizophrenics is higher in high school education (33.8%) and junior and PT education is equal to 13, 8%, The marital status of schizophrenics sufferers with mental disorders is more with marital status (61%), there are more conflicts in families with schizophrenia who do not have a family conflict (85%). Farewell events of Schizophrenia sufferers more than no parents (85%), Socio-economic status of schizophrenics in economic status less than 66 people (82.5%, Parenting schizophrenic parents democratic parenting 75 people or 93.8 %. It is expected that the results of this study may be used as scientific reading material in the library and can also be used as reference material that examines similar problems.
10
Vieweg, Victor, James Levenson, Anand Pandurangi, and Joel Silverman. "Medical Disorders in the Schizophrenic Patient." International Journal of Psychiatry in Medicine 25, no. 2 (June 1995): 137–72. http://dx.doi.org/10.2190/ttya-a89t-2yt9-uk2a.
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Objective: The primary purpose of this review of medical disorders in the schizophrenic patient is to provide the clinician interested in Consultation/ Liaison psychiatry and psychosomatic issues a comprehensive and current review of the subject. Method: The authors used the Index Medicus and Medline to find recent review articles and research articles related to medical disorders in the schizophrenic patient. Also, the authors described their clinical experience in Consultation/Liaison psychiatry working with schizophrenic patients in a large, tertiary-care academic medical center. Results: The authors divided their review into: 1) mortality and morbidity in schizophrenia, 2) differential diagnosis, 3) specific comorbidity management problems, 4) caring for schizophrenics on medical/surgical wards, and 5) antipsychotic drugs in the medical setting. Schizophrenia remains an important subject for Consultation/Liaison psychiatrists. Conclusions: Schizophrenia and its protean manifestations confound the care of the medical patient. The psychosis of schizophrenia may impair the patient's capacity to recognize or articulate emerging medical illness, or to respond to therapeutic interventions. The psychiatrist caring for and consulting on patients with medical illnesses bears major responsibility for understanding the complex interface of schizophrenia and medical illnesses. Psychiatrists need to educate our medical and surgical colleagues how schizophrenia alters the usual presentation, clinical course, and response to treatment of common medical and surgical illnesses.
11
Ozeki, Tomoe, Tetsuya Mouri, Hiroko Sugiura, Yuu Yano, and Kunie Miyosawa. "Impression Survey and Grounded Theory Analysis of the Development of Medication Support Robots for Patients with Schizophrenia." Journal of Robotics and Mechatronics 33, no. 4 (August 20, 2021): 747–55. http://dx.doi.org/10.20965/jrm.2021.p0747.
Abstract:
Medication is a key treatment for patients with schizophrenia. Patients with schizophrenia tend to easily decrease medication adherence with long-term treatment. However, there is a chronic shortage of specialists who provide medication support, such as visiting nurses. In addition, these patients do not often use smartphones or PCs in their daily lives. Thus, schizophrenic patients need a direct approach in the physical world because they are unfamiliar with cyberspace. This study aims to improve the home treatment environment using robot technology that can approach in the physical world of schizophrenic patients who need medication support. In this study, collaboration between psychiatric nursing specialists and medical engineers investigated the interaction between communication robots and patients. The results showed that the robot was accepted by patients with schizophrenia as a talking partner. The amount of robot talking seemed to affect the impression of the robot on schizophrenics. Utterance process analysis showed that the smoothness of the conversation affected the relationship between robots and schizophrenics.
12
Jessica, Lia, Izzatul Fithriyah, and I. Gusti Ayu Indah Ardani. "The Importance of Family Support in Successful Treatment Adherence of Schizophrenic Patient." Jurnal Psikiatri Surabaya 10, no. 2 (September 27, 2021): 83. http://dx.doi.org/10.20473/jps.v10i2.26453.
Abstract:
Background: Schizophrenia is a treatable disease but requires patient’s high adherence to treatment. Family support of a schizophrenic patient plays an important role in encouraging the patient to continue his treatment. This report aims to enhance the importance of family support of schizophrenic patient in patient’s adherence to achieve a good mental health for all family member.Case: A hospitalized male paranoid schizophrenic patient who was admitted and observed in Dr. Soetomo General Hospital from September 15th-25th, 2020. Patient came to the hospital with chief complaint could not stop talking (rambling) since 1 day before admission. Patient could neither eat nor sleep for that day. Patient relapsed after stopping taking medication from the psychiatrist.Discussions: The patient in this case suffered a relapse of his paranoid schizophrenia because he stopped taking medication. Lack of support from family is the most important factor in a schizophrenia patient. Psychoeducation to patient’s family about schizophrenia and the importance of medication would be a great help for patient’s adherence to treatment.Conclusions: Schizophrenia needs a long-life treatment. High adherence to treatment could improve schizophrenia’s symptoms and prevent relapse. Family support is important to make sure the patient keeps taking his medicine regularly.
13
Karaman, Taha, Sibel Özkaynak, Korkut Yaltkaya, and Çetin Büyükberker. "Bereitschaftpotential in schizophrenia." British Journal of Psychiatry 171, no. 1 (July 1997): 31–34. http://dx.doi.org/10.1192/bjp.171.1.31.
Abstract:
BackgroundSeveral reports have documented the presence of motor abnormalities in schizophrenic patients.MethodThirty schizophrenics and 28 healthy controls were included in the study. Scalp-recorded bereitschaftpotentials (BPs) generated prior to voluntary movements were recorded in all subjects.ResultsThe early (NSI) and late components of BP and peak negativity were reduced in all schizophrenic patients. In particular, the NSI was reduced in patients with positive symptoms, and the late component in patients with negative symptoms.ConclusionsThese findings provide further support for the involvement of frontal cortex, subcortical structures and their connections in schizophrenia, and highlight some differences between positive and negative symptom clusters.
14
Chaleby, Kutaiba, and T. A. Tuma. "Cousin Marriages and Schizophrenia in Saudi Arabia." British Journal of Psychiatry 150, no. 4 (April 1987): 547–49. http://dx.doi.org/10.1192/bjp.150.4.547.
Abstract:
The rate and degree of consanguinity in the parents of 143 schizophrenics who satisfied the DSM-III diagnostic criteria, was compared in the same number of controls matched for age, sex and socioeconomic class. A family history of disorders suggestive of schizophrenia in the offspring of consanguineous parents who were schizophrenic, was compared with the incidence of a similar history in the schizophrenic offspring of non-consanguineous parents. There was no statistically significant difference in the former, but there was in the latter. This finding supports the theory of a familial tendency towards schizophrenia and the possibility of recessive or a multigene pattern of inheritance.
15
Lyons, Michael J., Jonathan Huppert, Rosemary Toomey, Rebecca Harley, Jack Goldberg, Seth Eisen, William True, Stephen V. Faraone, and Ming T. Tsuang. "Lifetime prevalence of mood and anxiety disorders in twin pairs discordant for schizophrenia." Twin Research 3, no. 1 (February 1, 2000): 28–32. http://dx.doi.org/10.1375/twin.3.1.28.
Abstract:
AbstractThere have been long questions about the relationship of schizophrenia to other mental disorders. Lifetime DSM-III-R diagnoses of mood and anxiety disorders in twins with clinically diagnosed schizophrenia (n = 24) and their non-affected co-twins (n = 24) were compared with twins from pairs without schizophrenia (n = 3327) using a sample from the Vietnam Era Twin Registry. Schizophrenic probands had significantly elevated rates of all included disorders (bipolar disorder, major depression, dysthymia, generalized anxiety disorder, panic disorder, and PTSD) compared with controls (P < 0.01). The odd ratios comparing co-twins of schizophrenic probands with controls was greater than three for every disorder, but did not attain statistical significance. A similar pattern was observed when analyses were restricted to only monozygotic twins (n = 12). Consistent with other studies, schizophrenics appeared to have higher rates of a range of mental disorders. Our results suggest that schizophrenia per se represents a risk factor for other psychiatric disorders, but the absence of significantly elevated risk among non-schizophrenic co-twins suggested that family environmental and/or genetic factors that contribute to risk of schizophrenia do not increase the risk of mood and anxiety disorders to the same extent that the risk of these other disorders is increased by the presence of schizophrenia. Twin Research (2000) 3, 28–32.
16
Chaves, Monica, Natália Mota, Sidarta Ribeiro, Mario Copelli, and Cilene Rodrigues. "M190. USE OF NULL PRONOUNS IN SCHIZOPHRENIA." Schizophrenia Bulletin 46, Supplement_1 (April 2020): S208. http://dx.doi.org/10.1093/schbul/sbaa030.502.
Abstract:
Abstract Background Schizophrenic speech show consistent disturbances in referentiality, which, from a communicative standpoint, manifest as incoherent speech. Referential failures are especially detected in the usage of pronouns. Literature reports that schizophrenics either use more pronouns without clear reference or more semantically rich anaphors than pronouns. Additionally, it is reported that psychosis language in the context of schizophrenia, schizo-affective disorder and bipolar disorder present more first-person pronouns; within individuals at high genetic risk of schizophrenia those who subsequently developed schizophrenia produced significantly more second-person pronouns than those who did not manifest the illness; and individuals with diagnosis of primary psychotic disorder increased their usage of pronouns, including first-person and second-person pronouns during the period prior to a relapse hospitalization. The abnormalities observed in the use pronouns suggest that schizophrenic patients have semantic-pragmatic issues. There are not many experimental studies devoted to pronouns in schizophrenia, and, according to our current knowledge, none of the existent ones focuses on pronouns without phonological content (null pronouns). In order to fulfill this gap, we present here an investigation of null pronouns in dream narratives produced by Brazilian schizophrenia patients. Methods Dream narratives from 20 schizophrenics and 20 control subjects, all native speakers of Brazilian Portuguese, were screened for null subject pronouns. Participants were prompt to talk by the command: “please report a recent dream”. Each narrative sample was then transcribed, and the occurrence of subject null pronouns were annotated, together with its morphosyntactic features (person & number) and referential status (referential vs. non-referential/expletives). The number of overt and null (with and without phonological content respectively) pronouns in subject position were converted into ratios by dividing the number of occurrences of each pronoun type (overt and null) by the total number of words in the narrative. Next, overt and null pronouns were compared within and between groups. Results T-test comparison showed that the schizophrenia group produced significantly more null pronouns than control group (t(25.126) = 3.919; p = .001); and, that null pronouns were significantly more produced than overt pronouns in the schizophrenia group (t(38) = 3.242; p = .002). Multiple regression showed that total of null pronouns differentiate schizophrenia from control group (F(1,38) = 15.357, p = .001, R2 = .288). In addition, analysis of null pronoun differences between groups based on morphosyntactic features and referential status, showed that schizophrenics used significantly more null pronouns with third-person singular features (t(27.523) =2.699; p =.012) and non-referential pronouns (expletives) (t(23.608) = 2.808; p = 0,010) than control group. Discussion A closer look at third-person null pronouns in the schizophrenic narratives showed that these pronouns are quite often loose in terms of reference: of the total occurrences of third-person null pronouns in schizophrenia approximately 30% are without clear referent. In accordance, null expletives, which are empty of reference, are overused to the point of explaining group differences. This corroborates that schizophrenic speech has a reduced semantic-pragmatic load, with a general difficulty in using pronouns within a contextually framed discourse.
17
Sweden, B. Van, M. G. Van Erp, F. Mesotten, and M. Maes. "Frontal cortex reactivity differentiates between schizophrenic subtypes: auditory ERP-evidence." Acta Neuropsychiatrica 13, no. 3 (September 2001): 61–67. http://dx.doi.org/10.1017/s0924270800035249.
Abstract:
SUMMARYObjectives: To extend the hypothesis that late auditory EP shifts represent pathophysiologcial markers in schizophrenia. Methods: Early negative (±100 μs) and late positive (>300 ms) auditory oddball and CNV responses are topographically compared in 3 medicated schizophrenic subtypes.Results: Only late cortical responses differentiate between paranoid, residual and disorganised schizophrenia. Core features of the deficit residual state encompass low-voltage N2P3 responses and missing central initial CNV components. Both paranoid and disorganised schizophrenics show a distinctive reactivity of the frontal cortex. Paranoid schizophrenia is characterized by an extensive frontal spread of the task-related P3 response. Disorganised schizophrenia shows a specifically increased frontal CNV component indicating a nonspecific arousal reaction.Conclusion: Combinations of late auditory EP-patterns fairly fit with the cognitive/behavioral status observed in schizophrenia spectrum disorders.
18
Ambekar, Prakash. "Perspective study of disorders of thought, language and communication in schizophrenic patients of Maharashtra." Panacea Journal of Medical Sciences 13, no. 1 (April 15, 2023): 15–18. http://dx.doi.org/10.18231/j.pjms.2023.004.
Abstract:
Schizophrenia is a mental disorder characterised by paranoid, hallucination and delirium. The person with such disorder cannot lead a normal life in the society due to his abnormal communication and thought disorder. Hence such disorders are helpful to diagnose the type and severity of disease. Out of 1000 (one thousand) patients 500 were acute schizophrenia and 500 were chronic schizophrenics. Among 1000, 330 were paranoid and 670 were non-paranoid. The disorder of FTD, language, communication disorders in acute, chronic non-paranoid and paranoid schizophrenia were noted. In the comparison of acute and chronic schizophrenic patients – Negative FTD scores positive negative FTD scores, language disorders score was highly significant (p<0.001). In the schizophrenic negative FTD score Negative positive FTD scores, thought disorder score, language disorder scores were highly significant (p<0.001). This study will be helpful to psychiatrist to differentiate acute and chronic schizophrenic patients and treat them efficiently with proper medication so that such patients can lead normal social and family life.
19
Caldwell, Constance B., and Irving I. Gottesman. "Schizophrenia—A High‐Risk Factor for Suicide: Clues to Risk Reduction." Suicide and Life-Threatening Behavior 22, no. 4 (December 1992): 479–93. http://dx.doi.org/10.1111/j.1943-278x.1992.tb01040.x.
Abstract:
ABSTRACT: Suicide is the chief cause of premature death among schizophrenic persons. The lifetime incidence of suicide for patients with schizophrenia is 10% to 13% compared to a general population estimate of about 1%, and is quite close to that observed among those with major affective disorder. The magnitude of increased risk for suicide among schizophrenics peaks before middle age and declines thereafter, although schizophrenic persons tend to be at increased risk throughout the life span. Among psychiatric patients, schizophrenics are overrepresented among suicides, and often schizophrenics constitute the majority of inpatient suicides. It is important in evaluating suicide risk among schizophrenic persons to assess depression and suicidal ideation especially during index admission and during acute phases of the illness. It is noteworthy that schizophrenic persons often commit suicide as the overall level of psychopathology decreases during a nonpsychotic phase. Research has yielded salient risk factors for suicide in schizophrenic persons and “types” of especially vulnerable patients, even though statistical prediction of individual suicides has not proven effective.
20
Sierra-Honigmann, A. M., K. M. Carbone, and R. H. Yolken. "Polymerase Chain Reaction (PCR) Search for Viral Nucleic Acid Sequences in Schizophrenia." British Journal of Psychiatry 166, no. 1 (January 1995): 55–60. http://dx.doi.org/10.1192/bjp.166.1.55.
Abstract:
BackgroundPrevious studies looking for evidence of viral infection in schizophrenics have yielded conflicting results. We searched for viral nucleic acids to test the hypothesis of the viral aetiology of schizophrenia.MethodWe used the polymerase chain reaction (PCR) to search for cytomegalovirus (CMV), human immunodeficiency virus (HIV), influenza A, Borna disease virus (BDV), and bovine viral diarrhoea virus (BVDV) in: hippocampus from three schizophrenic and three non-schizophrenic subjects; cerebrospinal fluid (CSF) from 48 schizophrenic patients; CSF and peripheral blood mononuclear cells (PBMC) from nine sets of identical twins discordant for schizophrenia; and SK-N-SHEP cells co-cultured with schizophrenic and non-schizophrenic brain homogenates. All patients met DSM–III–R criteria.ResultsVirus-specific nucleic acids were not found in any of the samples tested.ConclusionsThe absence of viral nucleic acids in the samples tested suggest that, in these patients, schizophrenia is not associated with a persistent or latent infection due to these viruses.
21
Elfaki, Amani Abdelrazag, Abdelrazag Elfaki, Tahir Osman, Bunyamin Sahin, Abdelgani Elsheikh, Amira Mohamed, Anas Hamdoun, and Abdelrahman Mohammed. "STEREOLOGICAL EVALUATION OF BRAIN MAGNETIC RESONANCE IMAGES OF SCHIZOPHRENIC PATIENTS." Image Analysis & Stereology 32, no. 3 (November 12, 2013): 145. http://dx.doi.org/10.5566/ias.v32.p145-153.
Abstract:
Advances in neuroimaging have enabled studies of specific neuroanatomical abnormalities with relevance to schizophrenia. This study quantified structural alterations on brain magnetic resonance (MR) images of patients with schizophrenia. MR brain imaging was done on 88 control and 57 schizophrenic subjects and Dicom images were analyzed with ImageJ software. The brain volume was estimated with the planimetric stereological technique. The volume fraction of brain structures was also estimated. The results showed that, the mean volume of right, left, and total hemispheres in controls were 551, 550, and 1101 cm³, respectively. The mean volumes of right, left, and total hemispheres in schizophrenics were 513, 512, and 1026 cm³, respectively. The schizophrenics’ brains were smaller than the controls (p < 0.05). The mean volume of total white matter of controls (516 cm³) was bigger than the schizophrenics’ volume (451 cm³), (p < 0.05). The volume fraction of total white matter was also lower in schizophrenics (p < 0.05). Volume fraction of the lateral ventricles was higher in schizophrenics (p < 0.05). According to the findings, the volumes of schizophrenics’ brain were smaller than the controls and the volume fractional changes in schizophrenics showed sex dependent differences. We conclude that stereological analysis of MR brain images is useful for quantifying schizophrenia related structural changes.
22
Smutzer, Gregory, Virginia M. Y. Lee, John Q. Trojanowski, and Steven E. Arnold. "Human Olfactory Mucosa in Schizophrenia." Annals of Otology, Rhinology & Laryngology 107, no. 4 (April 1998): 349–55. http://dx.doi.org/10.1177/000348949810700415.
Abstract:
Recent evidence indicates that developmental anomalies may underlie some symptoms of schizophrenia, while psychophysical studies have demonstrated olfactory deficits in this disease. The postmortem olfactory mucosa of elderly schizophrenic patients was examined to characterize the molecular phenotype of this tissue. The distribution of developmentally regulated cytoskeletal proteins, a synaptic vesicle protein, a neural marker protein, a receptor for trophic molecules, axonal guidance and cell migration proteins, and neuronal and glial cytoskeletal proteins of various degrees of phosphorylation was examined by immunohistochemistry. Both schizophrenic and control subjects exhibited dystrophic neurites that were immunoreactive for synaptophysin, microtubule-associated proteins (MAP1B), and neurofilament proteins. No major histochemical or morphologic differences in either the expression or distribution of these proteins were observed in the olfactory epithelium of schizophrenic compared to control subjects. These studies indicated that dystrophic neurites frequently occurred in the olfactory mucosa of both schizophrenics and neurologically normal adults. The absence of major immunocytochemical abnormalities suggested that olfactory deficits in schizophrenia may be due to more subtle cellular or molecular differences or to abnormalities in olfactory regions of the central nervous system rather than in the olfactory epithelium.
23
Szendi Md Habil, I., S. Szalóki, A. Bagi, E. Rudics, and E. Hallgató. "Research of time processing disorder within the investigation of specific traits of schizophrenia." European Psychiatry 65, S1 (June 2022): S248. http://dx.doi.org/10.1192/j.eurpsy.2022.640.
Abstract:
Introduction Schizophrenia is essentially related to one’s self-perception and the relationship to the world. One possible explanation for symptoms of schizophrenia in activities is the disruption of timing, which can develop into a disorder of activity perception and attribution. Objectives Our study aimed to investigate the specificity of time perception disorder within the schizophrenia-bipolar spectrum, within the time interval around one second. Methods In the study, N = 15 schizophrenic (M = 37.28 years, SD = 9.49 years), N = 9 bipolar (M = 49.44 years, SD = 8.48 years), N = 10 schizoaffective (M = 41.32 years, SD = 10.75 years) patients with compensated clinical condition and N = 28 healthy control subjects (M = 36.5 years, SD = 9.9 years) participated. Time processing was examined with a perceptual (discrimination) and a productive (synchronization) task. Results Concerning the interval discrimination, patients with schizophrenia and schizoaffective disorder lag behind controls in the majority of indicators (0.373–0.772). In terms of production and reproduction, the deviation of schizoaffective patients indicates a moderate difference, but subjects with schizophrenia show a large effect size, and subjects with bipolar disorder demonstrate a small effect size. Conclusions Our results suggest that the schizophrenic group exhibits a comprehensive time-processing disorder and in this respect can be distinguished from the bipolar affective and the control group. People with schizoaffective disorder show an intermediate performance in reproduction between the schizophrenic and bipolar groups, while in the case of discrimination deficit, they approach schizophrenics. Disclosure No significant relationships.
24
Kramer, Ivan, and L. Elliot Hong. "A Novel Model of Schizophrenia Age-of-Onset Data Challenges the Conventional Interpretations of the Discordance in Monozygote Twin Studies." ISRN Psychiatry 2013 (August 21, 2013): 1–10. http://dx.doi.org/10.1155/2013/604587.
Abstract:
The relative importance of genetics and the environment in causing schizophrenia is still being debated. Although the high proportion of monozygote cotwins of schizophrenia patients who are discordant suggests that there may be a significant environmental contribution to the development of schizophrenia, this discordance is predicted by an accumulative multimutation model of schizophrenia onset constructed here implying a genetic origin of schizophrenia. In this model, schizophrenics are viewed as having been born with the genetic susceptibility to develop schizophrenia. As susceptible gene carriers age, they randomly accumulate the necessary mutations to cause schizophrenia, the last needed mutation coinciding with disease onset. The mutation model predicts that the concordance rate in monozygote twin studies will monotonically increase with age, theoretically approaching 100% given sufficient longevity. In dizygote cotwins of schizophrenia patients, the model predicts that at least 71% of cotwins are incapable of developing schizophrenia even though every cotwin and their schizophrenic twin shared a similar early environment. The multimutation model is shown to fit all of the monozygote and dizygote concordance rate data of the principle classical twin studies completed before 1970 considered in this paper. Thus, the genetic hypothesis of schizophrenia can be tested by bringing these studies up to date.
25
Schoepf, D., R. Potluri, H. Uppal, A. Natalwala, P. Narendran, and R. Heun. "Type-2 diabetes mellitus in schizophrenia: Increased prevalence and major risk factor of excess mortality in a naturalistic 7-year follow-up." European Psychiatry 27, no. 1 (January 2012): 33–42. http://dx.doi.org/10.1016/j.eurpsy.2011.02.009.
Abstract:
AbstractObjectivePhysical co-morbidity including type 2 diabetes mellitus is more prevalent in patients with schizophrenia compared to the general population. However, there is little consistent evidence that co-morbidity with diabetes mellitus and/or other diseases leads to excess mortality in schizophrenia. Thus, we investigated whether co-morbidity with diabetes and other somatic diseases is increased in schizophrenics, and if these are equally or more relevant predictors of mortality in schizophrenia than in age- and gender-matched hospitalised controls.MethodsDuring 2000–2007, 679 patients with schizophrenia were admitted to University Hospital Birmingham NHS Trust. Co-morbidities were compared with 88,778 age- and gender group-matched hospital controls. Predictors of mortality were identified using forward Cox regression models.ResultsThe prevalence of type 2 diabetes mellitus was increased in schizophrenia compared to hospitalised controls (11.3% versus 6.3%). The initial prevalence of type 2 diabetes mellitus was significantly higher in the 100 later deceased schizophrenic patients (24.0%) than in those 579 surviving over 7 years (9.2%). Predictors of mortality in schizophrenia were found to be age (relative risk [RR] = 1.1/year), type 2 diabetes mellitus (RR = 2.2), pneumonia (RR = 2.7), heart failure (RR = 2.9) and chronic renal failure (RR = 3.2). The impact of diabetes mellitus on mortality was significantly higher in schizophrenia than in hospital controls (RR = 2.2 versus RR = 1.1). In agreement, deceased schizophrenics had significantly suffered more diabetes mellitus than deceased controls (24.0 versus 10.5%). The relative risks of mortality for other disorders and their prevalence in later deceased subjects did not significantly differ between schizophrenia and controls.ConclusionSchizophrenics have more and additionally suffer more from diabetes: co-morbidity with diabetes mellitus is increased in schizophrenia in comparison with hospital controls; type 2 diabetes mellitus causes significant excess mortality in schizophrenia. Thus, monitoring for and prevention of type 2 diabetes mellitus is of utmost relevance in hospitalised patients with schizophrenia.
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Günther-Genta, Flavia, Pierre Bovet, and Patrick Hohlfeld. "Obstetric Complications and Schizophrenia a Case-Control Study." British Journal of Psychiatry 164, no. 2 (February 1994): 165–70. http://dx.doi.org/10.1192/bjp.164.2.165.
Abstract:
Schizophrenics have been repeatedly found to experience more obstetric complications (OCs) at birth. The meaning of such a finding is debated, and the aim of this study is to contribute to the understanding of OCs' aetiological role in schizophrenia. We compared a group of schizophrenic patients with their siblings and controls, on the basis of obstetric files stemming from the same University Hospital Maternity Ward. Schizophrenic patients had more frequent umbilical cord complications and atypical presentations, as well as higher scores on a scale measuring OCs linked to possible neonatal asphyxia.
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Schroeder, J., M. S. Buchsbaum, B. V. Siegel, F. J. Geider, R. J. Haier, J. Lohr, J. Wu, and S. G. Potkin. "Patterns of cortical activity in schizophrenia." Psychological Medicine 24, no. 4 (November 1994): 947–55. http://dx.doi.org/10.1017/s0033291700029032.
Abstract:
SynopsisEighty-three patients with schizophrenia and 47 healthy controls received positron emission tomography (PET) with 18F-2-deoxyglucose uptake while they were executing the Continuous Performance Test (CPT). The entire cortex was divided into 16 regions of interest in each hemisphere, four in each lobe of the brain, and data from corresponding right and left hemispheric regions were averaged. Data from the schizophrenic patients were subjected to a factor analysis, which revealed five factors that explained 80% of the common variance. According to their content, the factors were identified and labelled ‘parietal cortex and motor strip’, ‘associative areas’, ‘temporal cortex’, ‘hypofrontality’ (which included midfrontal and occipital areas) and ‘frontal cortex’. Hemispheric asymmetry was only confirmed for the temporal cortex. Factor weights obtained in the schizophrenic group were applied to the metabolic data of the healthy controls and factor scales computed. Schizophrenics were significantly more hypofrontal than the controls, with higher values on the ‘parietal cortex and motor strip’ factor and a trend towards higher values in the temporal cortex. A canonical discriminant analysis confirmed that the ‘hypofrontality’ and ‘parietal cortex and motor strip’ factors accurately separated the schizophrenic group from the healthy controls. Hemispheric asymmetry was only confirmed for the temporal lobe. Significantly higher factor scores for the left temporal lobe in schizophrenics than in normals were obtained when calculated for the right and left hemisphere separately. Taken together, our results confirm the importance of hypofrontality as a pattern of cortical metabolic rate and point to the potential importance of parietal and motor strip function in schizophrenia.
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Purba, Jenny Marlindawani. "CAREGIVERS’ NEEDS IN CARING FOR RELATIVES WITH SCHIZOPHRENIA IN MEDAN INDONESIA: A PHENOMENOLOGICAL STUDY." Belitung Nursing Journal 3, no. 6 (December 28, 2017): 656–61. http://dx.doi.org/10.33546/bnj.192.
Abstract:
Background: A caregiver is a primary nurse and has a major role in providing care for people with schizophrenia. Caring for those with schizophrenia for a long period of time is a challenge for families, especially caregivers. Various needs ought to be studied by nurses to assist caregivers in providing optimal care for family members who experience schizophrenia.Objective: This qualitative study aims to explore the needs of caregivers in treating schizophrenia at home.Methods: The method used in this study is the method of purposive sampling with the number of participants as many as 10 people with criteria: 1) have family members diagnosed with schizophrenia, 2) directly involved in home care patients, 3) caring for schizophrenia for more than one year, 4) willing to be a participant by signing informed consent, 4) being able to identify what is needed in treating schizophrenia. Colaizzi is used to analyze interview data.Results: The results of the study found four themes of caregiver needs in caring for schizophrenia patients at home, ly: 1) seeking information about schizophrenia, 2) sought schizophrenic relatives’ recovery, 3) looking for appropriate rehabilitation for relatives with schizophrenias, and 4) utilizing mental health facilities.Conclusions: It is expected that nurses have the knowledge and skills in identifying and helping families, especially caregivers, to meet unmet needs so they can optimize home care.
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Vandamme, Michel J., and Jean-Louis Nandrino. "Temperament and Character Inventory in Homicidal, Nonaddicted Paranoid Schizophrenic Patients: A Preliminary Study." Psychological Reports 95, no. 2 (October 2004): 393–406. http://dx.doi.org/10.2466/pr0.95.2.393-406.
Abstract:
This study assessed the personalities of 13 murderer schizophrenics using Cloninger's Temperament and Character Inventory, controlling different factors such as institution, treatment, detention or loss of liberty, and can discriminate between schizophrenic patients involved in homicide, schizophrenics with no past violent behavior, paranoiac murderers, and imprisoned murderers with no psychiatric history. Results show significantly that murderer schizophrenics had significantly higher scores on the subscale, Self-transcendence, than other groups, which suggests that Self-transcendence as measured may be an aggravating factor for schizophrenia and may be found in the personality of schizophrenic subjects who performed homicidal acts. This dimension constitutes a way and an additional element for diagnosis not available with the DSM–IV criteria. It may help understanding and predicting violent behavior among schizophrenic patients.
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Espina, Alberto, Asunción Ortego, Iñigo Ochoa de Alda, and Pilar González. "Dyadic adjustment in parents of schizophrenics." European Psychiatry 18, no. 5 (August 2003): 233–40. http://dx.doi.org/10.1016/s0924-9338(03)00063-4.
Abstract:
AbstractObjectiveTo study the dyadic adjustment in couples with a schizophrenic offspring.Method140 married couples, 67 with a children with schizophrenia, and two control groups: 41 couples without pathology and 32 couples with pathology, were assessed with the Dyadic Adjustment Scale, the Beck Depression Inventory and the Self-Rating Anxiety Scale.ResultsThe couples with a schizophrenic offspring evidenced significantly worse dyadic adjustment than did the normal controls, especially low consensus and cohesion in husbands, and low cohesion and satisfaction in wives. Anxiety and depression in mothers of schizophrenics is significantly higher than in mothers of controls.DiscussionThese findings suggest that the poor dyadic adjustment of the parents with a schizophrenic offspring could be an effect of the burden.ConclusionThe treatment on the schizophrenia should be supplemented by interventions aimed at parents’ dyadic adjustment, and mothers’ anxiety and depression, so that they can be in better conditions to help their child.
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Quinlan, Donald M., David Schuldberg, Hal Morgenstern, and William Glazer. "Positive and Negative Symptom Course in Chronic Community-Based Patients." British Journal of Psychiatry 166, no. 5 (May 1995): 634–41. http://dx.doi.org/10.1192/bjp.166.5.634.
Abstract:
BackgroundThe long-term symptom profile of chronic out-patients was studied.Method. 242 out-patients receiving neuroleptic medications (109 with schizophrenia and 133 non-schizophrenics), were studied for positive (SAPS) and negative (SANS) symptoms at baseline and at 24 months to investigate whether these symptom groups changed over out-patient maintenance treatment.ResultsOverall and within groups, negative symptoms decreased and positive symptoms increased. While the sums of the SANS scores for the schizophrenic patients were initially higher, their mean SANS score dropped more over time (P< 0.001), to show no difference from non-schizophrenics at follow-up. Positive symptoms increased in both groups, although schizophrenics were higher at both times; sub-scales within the SANS showed different patterns of change.ConclusionSupport is found for a multidimensional view of both positive and negative symptoms and for a reconsideration of the notion of ‘progressive downward course’ in schizophrenia.
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Ward, Philip B., Stanley V. Catts, Allison M. Fox, Patricia T. Michie, and Neil McConaghy. "Auditory Selective Attention and Event-Related Potentials in Schizophrenia." British Journal of Psychiatry 158, no. 4 (April 1991): 534–39. http://dx.doi.org/10.1192/bjp.158.4.534.
Abstract:
Brain ERPs were recorded in ten unmedicated schizophrenic patients and age- and sex-matched healthy controls during a multidimensional listening task. Patients showed a marked reduction in a long-duration attention-related negative ERP component, termed ‘processing negativity’ (PN), which was elicited by attended stimuli. The amplitude of PN was significantly correlated with SANS and SAPS scores of schizophrenic symptoms. The P300 component was also reduced in amplitude in patients, and was significantly correlated with SANS ratings of negative thought disorder. These findings provide neurophysiological evidence of impairment in the maintenance of selective attention and the cognitive processes associated with target detection among schizophrenic patients. The reduced PN in schizophrenics implicates frontostriatal pathways in the aetiology of attentional deficits in schizophrenia.
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Frangou, S., T. Sharma, T. Sigmundsson, P. Barta, G. Pearlson, and R. M. Murray. "The Maudsley Family Study 4. Normal planum temporale asymmetry in familial schizophrenia." British Journal of Psychiatry 170, no. 4 (April 1997): 328–33. http://dx.doi.org/10.1192/bjp.170.4.328.
Abstract:
BackgroundLoss or reversal of the normal asymmetry of the planum temporale (PT) has been reported in schizophrenia, and may be due to aberrations in the gene(s) controlling the development of brain asymmetries. We tested this hypothesis in a sample of schizophrenics and their relatives from families multiply affected with the disorder.MethodWe compared 32 schizophrenics and 55 of their non-schizophrenic first-degree relatives with 39 matched community controls. Volumetric measurements of the cortical volume beneath the PT were obtained using the Cavalieri method from three-dimensionally reconstructed magnetic resonance imaging images.ResultsPT volume asymmetry coefficients from patients and their relatives did not differ significantly from those of the controls. Gender-specific analysis did not reveal any differences.ConclusionsAbnormalities in PT volume asymmetry are not present in familial schizophrenia, where genetic factors appear to predominate.
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Manschreck, Theo C., Brendan A. Maher, Donna Ames, and Margaret L. Schneyer. "Impoverished Written Responses and Negative Features of Schizophrenia." Perceptual and Motor Skills 64, no. 3_suppl (June 1987): 1163–69. http://dx.doi.org/10.2466/pms.1987.64.3c.1163.
Abstract:
Repetition in the written language of schizophrenics and its possible relationships to other aspects of schizophrenic disorders are not well understood. We investigated repetitiousness in written utterances, finding schizophrenic subjects to be more repetitive than affective controls and normal controls. Over-all, written repetitiousness was more strongly correlated with psychopathologic features than oral repetitiousness. As in previous work, thought-disordered schizophrenic subjects produced the most repetitive responses. Poverty of content and illogical thinking were correlated with scores for written repetition. Measures of other negative features, disturbed mental functioning and motor behavior were also associated with repetitiousness in both written and oral modes. That these negative features are linked (namely, linguistic repetitiousness, negative formal thought disorder, voluntary motor abnormalities, and deficient mental functioning) is consistent with Crow's concept of a defect syndrome (Type 2) in schizophrenia.
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Bechdolf, Andreas, Frauke Schultze-Lutter, and Joachim Klosterkötter. "Self-experienced vulnerability, prodromal symptoms and coping strategies preceding schizophrenic and depressive relapses." European Psychiatry 17, no. 7 (November 2002): 384–93. http://dx.doi.org/10.1016/s0924-9338(02)00698-3.
Abstract:
SummaryFor the first time, the present study explores pre-episodic disturbances, i.e. self-experienced vulnerability and prodromal symptoms, and related coping strategies preceding schizophrenic and depressive relapses. After complete recovery from the acute episode, 27 patients with recurrent schizophrenic and 24 patients with recurrent depressive episodes were assessed retrospectively for pre-episodic disturbances and related coping strategies with the “Bonn scale for the assessment of basic symptoms—BSABS”. All (100%) of the schizophrenic and 23 (96%) of the depressive patients showed pre-episodic disturbances. Patients with schizophrenia showed significantly more often an increased emotional reactivity and certain perception and thought disturbances. Depressive patients reported significantly more often an impaired tolerance to certain stress and disorders of emotion and affect. Sixty-three percent of the schizophrenics and 87% of the depressives reacted to pre-episodic disturbances with coping strategies. The pre-episodic disturbances in patients with schizophrenia could be described in terms of mild psychotic productivity, those in depressives in terms of mild depressive syndrome. Future studies will have to show if these findings can be replicated in first episode or initial prodromal state samples and if the assessment of mild psychotic productivity and mild depressive syndrome can be used for early diagnosis and early intervention in schizophrenia and depression.
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Soyka, Michael, Sebastian Dittert, Martin Schäfer, Andreas Gartenmaier, Gerd Laux, Catja Winter, and Hans-Jürgen Möller. "Psychomotor Performance Under Neuroleptic Treatment in Schizophrenia." Zeitschrift für Neuropsychologie 12, no. 1 (February 2001): 49–53. http://dx.doi.org/10.1024//1016-264x.12.1.49.
Abstract:
Abstract: Cognitive dysfunction has been recognized as an important clinical feature of schizophrenia. The possible pharmacological effect of neuroleptics on cognitive and psychomotor function including driving ability is crucial for rehabilitation of schizophrenic patients. Atypical neuroleptics such as risperidone have been shown to improve cognitive deficits in schizophrenics. We conducted a naturalistic nonrandomized clinical study to determine the effect of risperidone on psychomotor function compared to haloperidol in schizophrenic patients. In this study the psychomotor performance of 26 patients, who met the ICD-10 and DSM-IV criteria for schizophrenia, was assessed by means of ART-90, a computer-based Act & React Testsystem. 11 patients were on risperidone (mean dosage 4.0 mg) and 15 patients on haloperidol (mean dosage 10.5 mg). Patients were examined at discharge after psychopathological stabilization. In some relevant items the patients in the haloperidol group showed more impaired performance compared to the patients in the risperidone group. These preliminary data indicate a possible beneficial effect of risperidone compared to haloperidol on psychomotor performance and driving ability. Further randomized trials are necessary.
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Kulynych, Jennifer J., Katalin Vladar, Bryan D. Fantie, Douglas W. Jones, and Daniel R. Weinberger. "Normal Asymmetry of the Planum Temporale in Patients with Schizophrenia." British Journal of Psychiatry 166, no. 6 (June 1995): 742–49. http://dx.doi.org/10.1192/bjp.166.6.742.
Abstract:
BackgroundAbnormal cerebral anatomical lateralisation has been reported in schizophrenia and may implicate anomalous neurodevelopment in the aetiology of this disease. A popular recent hypothesis has predicted that such disturbances in normal lateralisation should be especially apparent in the morphology of the temporal lobes.MethodA temporal cortical region lying in the plane of the Sylvian fissure – known as the planum temporale – exhibits pronounced leftward asymmetry in normal right-handed males. We compared lateralisation of the planum temporale in schizophrenic and control males using MRI surface-rendering morphometry of the supratemporal cortex.ResultsContrary to the lateralisation hypothesis, normal patterns of leftward planum asymmetry were detected in both the schizophrenic and control groups. Schizophrenics and controls also exhibited a predicted symmetry in the bilateral areas of Heschl's gyrus, a supratemporal cortical structure immediately anterior to the planum.ConclusionThese data do not support the notion that neurodevelopmental mechanisms of cerebral asymmetry are abnormal in schizophrenia.
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Cooper, Brian, and John M. Eagles. "Folnegović & Folnevogić-Šmalc's “Schizophrenia in Croatia: Inter-regional Differences in Prevalence and a Comment on Constant Incidence”." British Journal of Psychiatry 164, no. 1 (January 1994): 97–100. http://dx.doi.org/10.1192/bjp.164.1.97.
Abstract:
“Study objective - The aim was to examine why differences exist in schizophrenia prevalence and risk in some areas of Croatia, when schizophrenia incidence rates do not appear to vary. Design - Areas differing by schizophrenia admission rates in patients born in 1953 and admitted by the age of 31 years are compared using a number of indicators relating both to general population characteristics and to those of schizophrenic cases in these populations. Setting - The study covers the whole of Croatia (4 601 469 inhabitants, 1981 census). Subjects - By the age of 31 years, out of 80 445 individuals born in Croatia in 1953, 464 were admitted for and diagnosed as having schizophrenia. Main results - Admission risk rates are higher in those parts of Croatia where emigration rates are high and lower where immigration rates are high. There is also a positive correlation with schizophrenia prevalence and manic depressive psychosis rates. There is a negative correlation with age of onset of schizophrenia and with schizophrenic reproduction rates. In the study areas, hospital incidence rates are not significantly different. Conclusions - Economic migration and negative selection in the domestic population are likely to be the most significant factors leading to differences in schizophrenia prevalence. The approximately equal incidence rates in the population, with different prevalence and admission risks, are linked to differences in the disease onset among schizophrenics with a positive family history for this condition. In other words, these patients, when part of the population with a greater prevalence and a greater hereditary loading, experience the onset more often at an earlier age. Thus they have a lower reproduction rate than in a population with a lower prevalence and a lower hereditary loading. Thus incidence rates in populations with different prevalences and different hereditary loads are maintained roughly equal over generations.”
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Trishna, Alya Rahma, and Nalini Muhdi. "Clinical Manifestation Differences of Schizophrenia Patients Based on Gender." Jurnal Psikiatri Surabaya 9, no. 1 (June 1, 2020): 14. http://dx.doi.org/10.20473/jps.v9i1.16356.
Abstract:
Background: Schizophrenia is yet to be deeply understood, despite being one of the most common mental illnesses in the world. Male and female schizophrenic patients may show different clinical presentations. The differences have been studied extensively globally, but there has yet many reports in regards of this in Indonesia.Aims: Knowing the differences of clinical manifestation on schizophrenia patients based on gender.Method: This research is analytic study in retrospective design. The data is taken from medical records of male and female schizophrenic inpatients of Psychiatric Ward of Dr. Soetomo General Hospital Surabaya on January 1st to December 31st, 2018, in total of 75 samples included. Data is processed with ANOVA statistic method.Result: The prevalence of male schizophrenic inpatients is 65,3% and 34,7% for female inpatients, with the ratio of 1,88:1. The differences of clinical presentations are not significant for the following clinical manifestations; abnormal motor behaviour (P=0,281), delusion (P=0,240), disorganized thinking (P=0,306), diminished emotional expression (P=0,295), and avolition (P=0,633) clinical manifestations. There is a significant difference in hallucination clinical manifestation between male and female inpatients (P=0,037).Conclusion: There is a significant difference in schizophrenia’s clinical manifestation of hallucination between male and female inpatients.
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Maltais, Jean-Robert, Geneviève Gagnon, Marie-Pierre Garant, and Jean-François Trudel. "Correlation between age and MMSE in schizophrenia." International Psychogeriatrics 27, no. 11 (April 15, 2015): 1769–75. http://dx.doi.org/10.1017/s1041610215000459.
Abstract:
ABSTRACTBackground:The Mini-Mental State Examination (MMSE) is widely used in schizophrenia, although normative data are lacking in this population. This review and meta-regression analysis studies the effect of aging on MMSE scores in schizophrenic patients.Methods:We entered the search terms schizophrenia and MMSE in PubMed and PsychInfo. Bibliographies of pertinent articles were also examined. We included every study presenting the MMSE scores in schizophrenic patients along with a corresponding mean age. We conducted our analyses using simple linear regression weighted for the inverse of within-trial variance of the age variable, thus conferring more importance to studies with narrower age groups.Results:We identified 56 articles (n = 5,588) published between 1990 and 2012. The MMSE scores of schizophrenic patients decline by approximately 1 point for every four years (y = 34.939−0.247x, 95% Confidence Interval (CI) [−0.304, −0.189], R2 = 0,545), which is five times the rate in the general population. Institutionalized patients account for a large proportion of this decline (y = 37.603–0.308x, 95% CI [−0.349, −0.267], R2 = 0.622) whereas community-dwelling patients are relatively stable throughout aging (y = 27.591–0.026x, 95% CI [−0.074, 0.023], R2 = 0.037).Conclusions:Subgroup analyses show different trajectories between institutionalized and outpatients with schizophrenia. The deterioration observed in institutionalized patients may have to do with greater illness severity, heavier medication load, vascular risk factors, and lack of stimulation in institutional settings. Studies documenting the role of these variables would be useful. Cognitive screening tools that assess executive functions would be interesting to study in schizophrenics, as they may reveal more subtle age-related cognitive changes not measured by the MMSE.
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Crawford, J. R., J. A. O. Besson, M. Bremner, K. P. Ebmeier, R. H. B. Cochrane, and K. Kirkwood. "Estimation of Premorbid Intelligence in Schizophrenia." British Journal of Psychiatry 161, no. 1 (July 1992): 69–74. http://dx.doi.org/10.1192/bjp.161.1.69.
Abstract:
To determine whether the National Adult Reading Test (NART) would provide a valid estimate of premorbid intelligence in schizophrenia, two schizophrenic samples were recruited, one consisting of 35 patients resident in long-stay wards, the other of 29 patients normally resident in the community. Schizophrenic patients were individually matched for age, sex, and education with a healthy, normal subject. Both schizophrenic samples scored significantly lower on the Wechsler Adult Intelligence Scale (WAIS) than their respective control groups. NART-estimated IQ did not differ significantly between the community-resident schizophrenics and their controls, suggesting that the NART provides a valid means of estimating premorbid intelligence in such a population. NART-estimated IQ was significantly lower in the long-stay sample than in their controls. Although low NART scores in this latter sample could be a valid reflection of low premorbid IQ, the alternative explanation that NART performance was impaired by onset of the disease cannot be ruled out.
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Kendell, R. E., and W. Adams. "Unexplained Fluctuations in the Risk for Schizophrenia by Month and Year of Birth." British Journal of Psychiatry 158, no. 6 (June 1991): 758–63. http://dx.doi.org/10.1192/bjp.158.6.758.
Abstract:
Variation in their year and month of birth was studied in the 13 661 schizophrenics born between 1914 and 1960 known to the Scottish Psychiatric Case Register. Year-to-year fluctuations in the number of schizophrenics per 10 000 live births were outside chance limits. So were month-to-month fluctuations between January 1932 and December 1960, and this was largely due to fluctuations in the numbers of schizophrenics born in February, March, April and May. Time-lagged correlations with mean monthly temperatures suggest that in these same four months the incidence of schizophrenia is influenced by temperature six months previously – the lower the temperature in the autumn the higher the incidence of schizophrenic births the following spring. If these findings can be confirmed in other data sets, they would suggest that some influence which varies consistently with season and temperature is contributing to the aetiology of schizophrenia and may exert its effects as early as the third or fourth month of foetal development.
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Berenbaum, Howard, Thomas F. Oltmanns, and Irving I. Gottesman. "Hedonic capacity in schizophrenics and their twins." Psychological Medicine 20, no. 2 (May 1990): 367–74. http://dx.doi.org/10.1017/s0033291700017682.
Abstract:
SynopsisAudio-taped interviews recorded in the Gottesman–Shields schizophrenic twin series (17 pairs of identical twins, 14 pairs of fraternal same-sex twins, and 12 unpaired twins) were rated for level of hedonic capacity. Schizophrenics who were not hospitalized at the time of their interview were rated significantly lower (more impaired) on hedonic capacity than their normal co-twins. A significant negative correlation was also found between hedonic capacity and severity of illness. Hedonic capacity was found to be genetically influenced, although it appeared to be less heritable than the global diagnosis of schizophrenia. These results are consistent with Meehl's suggestion that reduced hedonic capacity is a heritable personality trait which potentiates the development of schizophrenia among those who are genetically predisposed to the disorder. The results suggest that anhedonia is not a phenotypic vulnerability marker for schizophrenia.
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Vijaywargia, Tarun. "Adjuvant role of testosterone in treatment of schizophrenia and its interaction with combination of first and second generation anti-psychotics, chlorpromazine and risperidone." International Journal of Basic & Clinical Pharmacology 7, no. 7 (June 22, 2018): 1247. http://dx.doi.org/10.18203/2319-2003.ijbcp20182422.
Abstract:
Background: There is great controversy about role of male sex steroid, testosterone, in mental disorders like schizophrenia. This study assessed the effectiveness of testosterone in schizophrenic patients and probes how it modulates the action of combination of first and second generation anti-psychotic medications (Chlorpromazine + Risperidone) both of which are very commonly used anti-psychotic agents in clinical psychiatric practice.Methods: It Is randomized, double-blind, Clinical study performed in Indian schizophrenic patients (new cases) in the Department of psychiatry from Feb 2003 to March 2004. Patients twelve (12) patients aged 20 to 60 years diagnosed schizophrenics according to ICD-10 Criteria who visited in outpatient department of psychiatry during study period. 12 Patient was treated with combination of oral Chlorpromazine 200mg BD + oral Risperidone 2mg BD, half of the 12 patients also received single dose of testosterone 100mg intramuscularly with above-mentioned treatment. Measure How symptomatology in schizophrenic patients affected is measured by applying various validated psychiatric scales like Brief psychiatric Rating Score (BPRS), Scale for assessment of positive symptom(SAPS), and Scale for Assessment of Negative Symptoms (SANS).Results: Single dose of Testosterone 100mg administered initially by I.M. route potentiated the reduction level in negative symptoms of schizophrenia by 119% in patients receiving oral Chlorpromazine 200mg along with oral Risperidone 4mg/day.Conclusions: In this study, Testosterone potentiated the effects of combination of oral Chlorpromazine 100mg BD + Risperidone 2mg BD, on general psychotic manifestations, positive symptoms and negative symptoms of schizophrenia, assessed on BPRS, SAPS and SANS scoring scales, however the effect is most pronounced in negative symptomology of schizophrenia.
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Henna Neto, Jorge, and Hélio Elkis. "Clinical aspects of super-refractory schizophrenia: a 6-month cohort observational study." Revista Brasileira de Psiquiatria 29, no. 3 (September 2007): 228–32. http://dx.doi.org/10.1590/s1516-44462007000300007.
Abstract:
OBJECTIVE: Approximately 30% of treatment-resistant schizophrenic patients do not fully respond to Clozapine and such patients are termed Clozapine non-responders or super-refractory schizophrenics. The aim of this study was to characterize patients with super-refractory schizophrenia according to demographic and psychopathological variables, as compared with patients with refractory schizophrenia or non-refractory subjects. METHOD: One hundred two outpatients meeting DSM-IV criteria for schizophrenia were followed-up for 6 months. Subjects were classified into 3 groups: non-refractory (n = 25), refractory (n = 43) and super-refractory (n = 34). Psychopathology was assessed by the Positive and Negative Syndrome Scale, the Schedule for Deficit Syndrome, the Calgary Depression Scale and the Quality of Life Scale. Patients were rated at 2-month intervals. RESULTS: Higher levels of severity at the disease onset as well as higher severity of positive symptoms were found to be predictive of super-refractoriness. CONCLUSIONS: The super-refractory schizophrenia patients have psychopathological predictive factors that need studies comparing brain images, genetical features and other clinical comparisons.
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Rivas, Juan, Santiago Gutierrez-Gomez, Juliana Villanueva-Congote, Jose Libreros, Joan Albert Camprodon, and María Trujillo. "Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study." Biomedicines 11, no. 1 (January 16, 2023): 233. http://dx.doi.org/10.3390/biomedicines11010233.
Abstract:
There are few studies on dementia and schizophrenia in older patients looking for structural differences. This paper aims to describe relation between cognitive performance and brain volumes in older schizophrenia patients. Twenty schizophrenic outpatients —10 without-dementia (SND), 10 with dementia (SD)— and fifteen healthy individuals —as the control group (CG)—, older than 50, were selected. Neuropsychological tests were used to examine cognitive domains. Brain volumes were calculated with magnetic resonance images. Cognitive performance was significantly better in CG than in schizophrenics. Cognitive performance was worst in SD than SND, except in semantic memory and visual attention. Hippocampal volumes showed significant differences between SD and CG, with predominance on the right side. Left thalamic volume was smaller in SD group than in SND. Structural differences were found in the hippocampus, amygdala, and thalamus; more evident in the amygdala and thalamus, which were mainly related to dementia. In conclusion, cognitive performance and structural changes allowed us to differentiate between schizophrenia patients and CG, with changes being more pronounced in SD than in SND. When comparing SND with SD, the functional alterations largely coincide, although sometimes in the opposite direction. Moreover, volume lost in the hippocampus, amygdala, and thalamus may be related to the possibility to develop dementia in schizophrenic patients.
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Martinot, J. L., M. L. Paillère-Martinot, C. Loc'h, P. Hardy, M. F. Poirier, B. Mazoyer, B. Beaufils, B. Mazière, J. F. Allilaire, and A. Syrota. "The Estimated Density of D2 Striatal Receptors in Schizophrenia." British Journal of Psychiatry 158, no. 3 (March 1991): 346–50. http://dx.doi.org/10.1192/bjp.158.3.346.
Abstract:
The striatal D2 receptors of 19 untreated schizophrenics and 14 normal control subjects were investigated with PET and 76Br-bromolisuride. The ratio of radioactivity in the striatum to that in the cerebellum was taken as an index of the striatal D2 receptor density. There was no significant difference between the control and the schizophrenic groups, nor any difference between subgroups of patients defined by clinical type or course of illness, and no relationship between the striatum:cerebellum activity ratio and SANS or SAPS ratings of symptoms. Unlike in the controls, this ratio was not correlated with age in schizophrenics. This study suggests that there is no quantitative abnormality of striatal D2 dopamine receptors in schizophrenia.
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Andrew, B., D. C. Watt, C. Gillespie, and H. Chapel. "A study of genetic linkage in schizophrenia." Psychological Medicine 17, no. 2 (May 1987): 363–70. http://dx.doi.org/10.1017/s0033291700024910.
Abstract:
SynopsisFamilies with more than one member affected by schizophrenia were identified and their members were interviewed. Four standardized diagnostic definitions (PSE, DSM-III, ICD-9, Feighner) were applied to all subjects who were classified as schizophrenic or not schizophrenic according to each definition. Non-schizophrenic psychiatric disorders which have been shown to be familially associated with schizophrenia were also identified. Twenty blood markers were ascertained for all subjects and evidence of co-segregation with schizophrenia was sought. No selective segregation was found and therefore there was no evidence suggesting linkage or supporting a monogenic theory of transmission of susceptibility to schizophrenia.
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Parnas, Josef. "Mates of Schizophrenic Mothers." British Journal of Psychiatry 146, no. 5 (May 1985): 490–97. http://dx.doi.org/10.1192/bjp.146.5.490.
Abstract:
SummaryBoth mates of schizophrenic mothers and a control group consisting of mates of non-schizophrenic mothers were diagnostically examined. The former were more frequently psychiatrically deviant than their controls, both with respect to a life-time syndrome diagnosis and a personality diagnosis. Mating between a schizophrenic mother and a father who suffered from schizophrenia spectrum disorder significantly increased the offspring's risk of developing a schizophrenia spectrum disorder himself. Assortative mating was negatively correlated with age of onset of maternal schizophrenia. It is proposed that defective emotional rapport or sub-psychotic features constitute the phenotypic traits by which assortative mating operates in schizophrenia.
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King, K., W. I. Fraser, P. Thomas, and R. E. Kendell. "Re-examination of the Language of Psychotic Subjects." British Journal of Psychiatry 156, no. 2 (February 1990): 211–15. http://dx.doi.org/10.1192/bjp.156.2.211.
Abstract:
To investigate whether language in schizophrenia deteriorated progressively, 11 schizophrenic subjects, 9 manic subjects and 9 controls were re-tested after an interval of three years using the computer-assisted syntactical analysis technique of Morice. In 13 of the 16 linguistic variables described as hallmarks of schizophrenic speech decline, deterioration was noted in schizophrenics in the direction predicted and relative to the manic and control groups. The deterioration was most pronounced in complexity and integrity of speech. One variable remained unchanged and two (semantic variables) showed marginal improvement. It was concluded that language, and in particular syntax, does deteriorate in the schizophrenic process.