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Cassafières, Cécile Dalhoumi Salah Fèvre Véronique Jove Camille Lefebvre Pascale Loiselet Martine Elaïdi Claudine. "Formation et évaluation en SCD." [S.l.] : [s.n.], 2005. http://www.enssib.fr/bibliotheque/documents/dcb/M-2005-RECH-02-vol1.pdf.
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Dempsey, Kate E. "Characterisation of a human stearoyl CoA desaturase gene (SCD2)." Thesis, Glasgow Caledonian University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369995.
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CAPUTO, MANUEL. "DEPDC1A, a novel SREBP1 cofactor, regulates fatty acid metabolism in breast cancer." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2924764.
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Breast cancer (BC) figures as the most frequently diagnosed and the leading cause of cancer-related deaths among women worldwide. Despite considerable progress has been made in cancer detection and therapy assignment, several BCs become resistant to therapy and, moreover, a considerable proportion of patients develops metastasis during therapy or experiences relapse.
Growing body of evidence indicates that alterations in tumour metabolism are linked to therapeutic resistance, tumour relapse and dissemination. These altered metabolic traits are caused by genetic alterations and environmental factors.
The most frequently mutated gene in BC is the tumor suppressor TP53, a well-characterized transcription factor, which plays a central role in cellular homeostasis and prevention of tumour growth. In BC missense mutations occur very often in its DNA binding domain, providing neomorphic mutant p53 proteins that lose the wildtype onco-suppressive functions and acquire instead new oncogenic properties (Gain-of-Function). Indeed, mutant p53 proteins establish aberrant interactions with different transcription factors, thus inducing oncogenic transcriptional programs and metabolic reprogramming.
Our previous work outlined a mutant p53 driven signature that promotes aggressiveness in BC in which DEP domain containing 1A (DEPDC1A) emerged as an important mediator of migration and invasiveness (Girardini et al., 2011). DEPDC1A expression is almost undetectable in normal cells, but it is overexpressed in different cancers and its overexpression is associated with poor prognosis. DEPDC1A is a transcriptional cofactor that exists in two different splice variants V1 and V2, but its role in oncogenesis, as well as in a physiological context, remains elusive.
Here we show, through a high-throughput transcriptional analysis, that DEPDC1A is able to impinge on lipid metabolism. In particular we observed that mRNAs belonging to the fatty acids biosynthesis pathway genes ATP-Citrate Lyase (ACLY), Stearoyl-CoA Desaturase 1 (SCD1) and Elongation Of Very Long Chain Fatty Acids 6 (ELOVL6) were consistently downregulated upon DEPDC1A silencing suggesting a key role for this factor in controlling fatty acid metabolism in cancer cells. Indeed, ablation of DEDPC1A caused a significant decrease of lipid droplets content and fatty acid desaturation in MDA-MB-231 cell line.
ACLY, SCD1 and ELOVL6, as a part of fatty acids biosynthesis pathway, are specific targets of Sterol Regulatory Element Binding Protein (SREBP) transcription factors, master regulators of lipid metabolism. Interestingly, protein co-immunoprecipitation and Chromatin Immunoprecipitation assays demonstrated that DEPDC1A physically interacts with SREBP1 and that it is required for an efficient transcriptional activation of this particular subset of genes, thus acting as transcriptional cofactor of SREBP1.
Finally, we showed that DEPDC1A, through SCD1 upregulation, is able to promote aggressive phenotypes, such as migration, and that DEPDC1A overexpression in normal cells is sufficient to induce sensitization toward SCD1 inhibition.
This study unveils a novel oncogenic transcriptional program induced by the aberrant interaction between DEPDC1A and SREBP1 transcription factor that is able to induce fatty acid biosynthesis and desaturation in cancer cells and to establish a metabolic addiction that can be potentially exploited in cancer therapy.
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Lundö, Emma, and Sara Norrman. "Ett förslag på hur föräldraskattningsinstrumentet SCDI-III kan valideras : en pilotstudie." Thesis, Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-176308.
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I denna studie ett förslag till validering av föräldraskattningsformuläret SCDI-III baserad på en genomförd pilotstudie. Studiens syfte är att undersöka hur väl föräldrars och förskolepedagogers skattning av deltagande barns språkförmåga med skattningsinstrumentet SCDI-III överensstämmer med resultaten av ett test som studieförfattarna utformade. Testmaterialet speglar direkt de frågor som ställs till vårdnadshavarna och förskolepedagoger i SCDI-III. Tio barn i åldersgruppen 2;5–3;10 år med svenska som starkaste språk, tio vårdnadshavare och tio förskolepedagoger deltog i studien. Studieförfattarna utformade ett eget testmaterial som i så hög grad som möjligt speglar frågeställningarna i föräldraskattsformuläret SCDI-III. Bildbenämning användes för ordförrådsdelen och BUSS-sagan användes för bedömning av meningskomplexitet och meningsbyggnad. Testningen av sju av barnen utfördes i det digitala mötesrummet Zoom och tre barn testades delvis på förskolan. Vårdnadshavarna och förskolepedagogerna fyllde i föräldraskattningsformuläret SCDI-III, varefter resultaten jämfördes. Resultatet visade generellt på en hög överensstämmelse mellan samtliga bedömargrupper. Det förelåg endast små skillnader mellan grupperna och dessa var förutom två ord (“förstå” och “dum”) inte statistiskt signifikanta. Slutsatsen var att deltagande vårdnadshavare och förskolepedagoger kunde skatta barnens språkliga förmåga i hög utsträckning. Studiens resultat pekar därmed på att föräldraskattningen SCDI-III kan vara värdefull som kompletterande information gällande barnets språkliga förmåga. Förslag på hur en större valideringsstudie kan genomföras diskuteras.In the present study, a suggestion is provided of how the parent report instrument, The Swedish Communicative Development Inventories (SCDI-III) can be validated. The suggestion is based on a conducted pilot study. The purpose of the study is to investigate how well parents and preschool teachers assessment of participating children’s language ability with the assessment instrument SCDI-III corresponds with the results of a test designed by the study authors. The test material directly reflects the questions asked to the guardians and preschool teachers in SCDI-III. Ten children in the age group 2;5-3;10 years old with Swedish as their strongest language, ten guardians and ten preschool teachers participated in the study. The study authors designed a test material which as closely as possible mirrored the content in the questions asked in the parent report SCDI-III. Picture-naming was used for the vocabulary part and the BUS-story test was used for the assessment of sentence complexity and sentence construction. The screening of seven of the children was performed in the digital meeting room Zoom, and three children were partially tested at the preschool. The guardians and preschool teachers filled in the parent report SCDI-III, and the results were compared. The results generally showed a high degree of agreement between all the assessment groups. There were only small differences between the groups and these, apart from two words ("understand" and "stupid") were not statistically significant. The conclusion was that participating guardians and preschool teachers could estimate the children’s language ability to a great extent. The results of the study indicate that the parent report SCDI-III, can be valuable as supplementary information regarding the children’s language ability. Suggestions on how a larger validation study may be carried out are discussed.
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Gaillard, Béatrice Duchemin Pierre-Yves. "Organiser la gestion des ressources électroniques dans un SCD de Sciences Humaines et Sociales le cas du SCD de Lyon 2 /." [S.l.] : [s.n.], 2005. http://www.enssib.fr/bibliotheque/documents/dcb/gaillard.pdf.
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Odeskog, Sanna, and Noomi Stenberg. "Validering av föräldraskattningsformuläret SCDI-III för svenska barn i tre års ålder." Thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-118710.
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Föräldraskattningsformuläret The Swedish Communicative Development Inventory (SCDI-III) är en modifierad form av MacArthur-Bates Communicative Development Inventorys tredje form (CDI-III), och har tagits fram som ett forskningsinstrument för undersökning av språkförmågan hos barn i åldersgruppen 2;6-4;0 år. Det är av stor betydelse att barn i riskzonen för att utveckla en språkstörning upptäcks i tid för att språket ska kunna stimuleras under gynnsamma utvecklingsfaser. Kliniskt verksamma personer har givit uttryck för ett behov av ett material som kan ge en överblick av ett barns språkförmåga inför vidare språkutredning. Behovet av ett sådant material bidrog till att validiteten hos SCDI-III behövde undersökas, vilket utgjorde grunden för föreliggande studie. Syftet var att validera det redan normerade föräldraskattningsformuläret SCDI-III med etablerade språktest för att undersöka om det kan användas för att identifiera barn som ligger i riskzonen för språkstörning. Fyrtioen barn (21 flickor och 20 pojkar) i åldersgruppen 3;0-3;11 med svenska som modersmål, och 41 vårdnadshavare deltog i studien. Barnens grammatiska förmågor undersöktes med valideringsinstrumenten SIT (Språkligt Impressivt Test) och Gramba (Grammatiktest för barn) och deras lexikala förmågor undersöktes med BNT (Boston Naming Test) och PPVT-III (Peabody Picture Vocabulary Test). Testningen utfördes på deras respektive förskolor och vårdnadshavarna fyllde i SCDI-III, varefter resultaten jämfördes. Medelstarka signifikanta korrelationer konstaterades mellan skattningarna på SCDI:s ordproduktionsdel och barnens resultat på BNT respektive PPVT-III, samt mellan föräldrarnas skattningar på formulärets meningsbyggnadsdel och testresultaten på Gramba. Inga signifikanta eller starka korrelationer för meningskomplexitetsdelen i SCDI-III hittades mot något av de fyra testen. Utöver dessa resultat framkom att flickor presterade signifikant bättre än pojkar på Gramba och de äldsta barnen fick signifikant högre resultat än de yngsta på BNT. Resultaten i föreliggande studie tyder på att olika metoder och perspektiv behövs för bedömning av barns språkförmågor. SCDI-III skulle därför kunna vara ett kompletterade verktyg i form av ett samtalsunderlag mellan kliniskt verksamma logopeder och vårdnadshavare, men kan inte användas som enskilt bedömningsinstrument.The Swedish Communicative Development Inventory (SCDI-III), a parent report instrument, is a modified form of the third version of the MacArthur-Bates Communicative Development Inventory, and has been developed as a research tool for the investigation of the language ability of children aged 2;6 - 4;0 years. It is of great importance that children who are most at risk of developing a language impairment are identified in time in order to increase the possibility to stimulate their language in favourable developmental phases. Clinicians have expressed a need for a material that can provide an overview of a child’s language ability, prior to carrying out further language assessment. The need of such material has contributed to the need for an investigation of the validity of SCDI-III, which has formed the basis for the present study. The purpose was to validate the already standardized parent estimation form SCDI-III with established language assessments to investigate whether it can be used to identify children who are at risk for language impairment. Forty-one children (21 girls and 20 boys) aged 3;0 - 3;11 years, with Swedish as their mother tongue, and 41 guardians participated in the study. The grammatical abilities of the children were examined using the validation tools SIT (Språkligt Impressivt Test) and Gramba (Grammatiktest för barn) and the lexical abilities were examined using BNT (Boston Naming Test) and PPVT-III (Peabody Picture Vocabulary Test). The testing was performed at their respective daycare center, and the guardians filled in SCDI-III, after which the results were compared. Moderate significant correlations were found between estimations in SCDI’s word production section and the children’s production on the BNT and the result of the PPVT-III, and between parents’ evaluations in the sentence construction section of the questionnaire and the test results on Gramba. No significant or strong correlations in the sentence complexity section of the SCDI-III were found on any of the four SLP assessments. In addition to these results, girls performed significantly better than boys on Gramba and the oldest children had significantly better results than the youngest on the BNT. The results of the present study suggest a need for different methods and perspectives for the assessment of children’s language abilities. SCDI-III could therefore be a complementary tool in providing a basis for discussion between practicing speech-language pathologists and guardians, but cannot be used as an assessment tool by itself.
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MacDonald, Marcia L. E., Eck Miranda van, Reeni B. Hildebrand, Brian W. C. Wong, Nagat Bissada, Piers Ruddle, Anatol Kontush, et al. "Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis." American Heart Association, 2008. http://hdl.handle.net/2429/9434.
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OBJECTIVE—Absence of stearoyl-CoA desaturase-1 (SCD1) in mice reduces plasma triglycerides and provides protection from obesity and insulin resistance, which would be predicted to be associated with reduced susceptibility to atherosclerosis. The aim of this study was to determine the effect of SCD1 deficiency on atherosclerosis. Methods and RESULTS—Despite an antiatherogenic metabolic profile, SCD1 deficiency increases atherosclerosis in hyperlipidemic low density lipoprotein receptor (LDLR)-deficient mice challenged with a western diet. Lesion area at the aortic root is significantly increased in males and females in two models of SCD1 deficiency. Inflammatory changes are evident in the skin of these mice, including increased intercellular adhesion molecule (ICAM)-1 and ulcerative dermatitis. Increases in ICAM-1 and interleukin-6 are also evident in plasma of SCD1-deficient mice. HDL particles demonstrate changes associated with inflammation, including, decreased plasma apoA-II and apoA-I and paraoxonase-1 and increased plasma serum amyloid A. Lipopolysaccharide-induced inflammatory response and cholesterol efflux are not altered in SCD1-deficient macrophages. In addition, when SCD1 deficiency is limited to bone-marrow derived cells, lesion size is not altered in LDLR-deficient mice. CONCLUSIONS—These studies reinforce the crucial role of chronic inflammation in promoting atherosclerosis, even in the presence of antiatherogenic biochemical and metabolic characteristics.
[The original version of this article, along with updated information and services is located on the World Wide Web at: http://atvb.ahajournals.org/cgi/content/full/29/3/341] [UBC users: please click on the UBC eLink icon at the bottom of this record]
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Chung, Ki Yong. "Metabolic and genetic regulation in adipose tissue of Angus and Wagyu steers raised to U.S. and Japanese endpoints." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/3909.
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We hypothesized that carcass and fatty acid composition of Angus and Japanese Black (Wagyu) steers would not differ if the steers were fed to a typical U.S. final weight, but that Wagyu steers fed to a typical Japanese endpoint body weight would have greater quality grades and softer fat than Angus steers. Sixteen Angus and 16 Wagyu 8-month-old, weaned steers were assigned to a corn-based diet for 8 or 16 months (n = 4 per breed type and time) or hay-based diet for 12 or 20 months (n = 4 per breed type and time) in a 2 x 2 x 2 factorial arrangement. USDA yield grade was greater at the Japanese endpoint than at the U.S. endpoint in Angus steers (breed x endpoint, P = 0.03). Intramuscular (i.m.) lipid continued to increase to over 20% in the Wagyu steers (P = 0.05), but attained a plateau (14.7%) by 16 months on feed in the Angus steers. These results confirm that Wagyu cattle must be raised to greater physiological maturity before they differ from Angus cattle in M. longissimus thoracis i.m. lipid concentration. Subcutaneous adipose tissue concentrations of oleic (18:1n-9) was greater in Wagyu steers than in Angus steers (P = 0.05). All monounsaturated fatty acids (MUFA) increased between the U.S. and Japanese endpoint, whereas slip points of lipids in s.c. adipose tissue were 10°C lower in Japanese endpoint steers than in U.S. endpoint steers (P = 0.01). Angus adipose tissue exhibited peak SCD enzyme activity at 16 months (corn-based diet) but activity in Wagyu adipose tissue was greatest at 20 months (hay-based diet) (breed x diet x endpoint, P = 0.08). However, SCD gene expression in Angus adipose tissue was maximal at 12 months (hay diet), whereas Wagyu adipose tissue had peak expression at 16 months (corn diet) (P < 0.03). Trans-10, cis-12 CLA has been reported as a potent inhibitor of adipocyte differentiation. CLA (40 µM) strongly decreased SCD and PPARγ expression in bovine adipocytes, even in the presence of 5 mM arginine. It can be concluded that arginine up-regulates bovine preadipocyte differentiation, and CLA antagonizes this effect.
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Hussain, Ghulam. "Rôle de la stéaroyl-CoA désaturase-1 dans le maintien de l'activité musculaire : étude d'un modèle lésionel pour la compréhension des altérations métaboliques caractéristiques de la sclérose latérale amyotrophique." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00921430.
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Les patients SLA et les souris modèles présentent un dysfonctionnement métabolique qui coïncide avec le changement de concentration de différentes espèces lipidiques. Notre hypothèse est qu'un tel dysfonctionnement métabolique au niveau musculaire conduirait aux premiers changements observés dans la SLA. Nous avons montré que l'expression de la stéaroyl-coenzyme A désaturase 1 (SCD1), une enzyme clé de la synthèse des acides gras mono-insaturés à partir des acides gras saturés, est diminuée dans le muscle avant les premiers symptômes moteurs observés chez les souris modèles de SLA. Dans ce modèle murin, les altérations en acides gras au niveau circulant et hépatique, traduisant les changements de SCD1,apparaissent lors des premiers symptômes de la pathologie. De plus, l'inhibition pharmacologique de l'activité de SCD1 mime le phénotype métabolique des souris modèles de SLA. Notre étude a ainsi montré que la diminution de la SCD1 joue un rôle important pour l'activité neuromusculaire. Elle module les besoins énergétiques, maintien l'activité musculaire par augmentation du métabolisme oxydatif et agit sur l'expression de gènes impliqués dans le développement et le fonctionnement de la jonction neuromusculaire. De plus, l'ablation du gène SCD1 stimule la récupération fonctionnelle musculaire après lésion du nerf. L'inhibition pharmacologique de SCD1 apporte également une protection au muscle. Nous avons pu conclure de cette étude qu'une modification de l'expression de SCD1 ainsi que du profil d'acides gras peut apporter une protection au muscle pour lutter contre la pathologie. En outre, des inhibiteurs de l'activité enzymatique de la SCD1 pourraient être développés comme traitement thérapeutique dans la SLA.
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Bruley, Caroline. "La section Sciences du SCD de Nice - Sophia Antipolis." [S.l.] : [s.n.], 2003. http://www.enssib.fr/bibliotheque/documents/dcb/rsbruley.pdf.
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Chung, Ki Yong. "Metabolic regulation of cattle adiposity in different breed types using two disparate diets." Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/1092.
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Fifteen steers were used to evaluate the difference of diets (corn-based for 8 mo or hay-based for 12 mo) and breeds (Angus; n = 7 or Wagyu; n = 8) in a completely randomized design with 2 x 2 factorial arrangement of treatments to test the hypothesis that there are differences in fatty acid metabolism and cellularity in subcutaneous (s.c.) and intramuscular (i.m.) adipose tissue between these breeds types. Fat thickness, carcass weight, overall maturity, and yield grade of Angus steers were higher than those of Wagyu steers fed either corn (34%, 22%, 3%, and 8% higher, respectively) or hay diets (20%, 8%, 10%, and 8% higher, respectively) (P < 0.03). Moreover, marbling scores tended (P = 0.70) to be greater in Angus steers than in Wagyu steers fed either diet. Lipogenesis from acetate in both s.c and i.m. adipose tissue was higher in Wagyu steers (212.82 and 86.23 nmol/(105 cells per 2 h)) than in the Angus steers (86.23 and 29.66 nmol/(105 cells per 2 h)). Also, acetate incorporation into fatty acids was greater in s.c. adipose tissue than in i.m. adipose tissue (P < 0.05). Subcutaneous adipose tissue stearoyl-CoA desaturase (SCD) activity was significantly greater in corn-fed steers and than in hay-fed steers (P < 0.05), but there was no difference in SCD activity between Angus and Wagyu steers (P > 0.05). Adipocyte cellularity data demonstrated that both breeds have more cells per gram adipose tissue and smaller cell volumes in i.m. adipose tissue than in s.c. adipose tissue. In s.c. adipose tissue, saturated fatty acids tended to be lower in corn-fed Angus and Wagyu steers than in hay-fed steers (P < 0.06). Similarly, monounsaturated fatty acids were higher in corn-fed Wagyu and Angus steers than in hay-fed Wagyu and Angus steers (P < 0.01). Slip point was positively correlated with percentage stearic acid in corn-fed and hay-fed steers, and there was a negative correlation between slip point and the SCD index. These data demonstrated that corn-based diets provide not only increased contents of monounsaturated fatty acid in Angus and Wagyu adipose tissue but also increased lipogenic activity.
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Krljes, S. "English validation study of the Schizophrenia Communication Disorder Scale (SCD)." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/850098/.
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Language defects are one of the nuclear features of schizophrenia, and difficulties in semantic memory processing have been considered to be at the core of these deficits. However, the underlying mechanisms of deficits in semantic memory processing and their relationship to the overt symptoms of schizophrenia are still not entirely understood. Furthermore, tools for assessing language deficits in schizophrenia are sparse and the existing ones are based on observations rather than a pathophysiological understanding of these deficits. The first part of this thesis is a literature review aiming to explore the underlying mechanisms of language deficits in schizophrenia. The review focuses on the findings produced by the studies employing event related potential techniques that aim to provide objective measures of pathophysiological mechanisms of language deficits and relate them to overt, behavioural symptoms in schizophrenia. Given the wealth of data produced by these studies, the review focuses on the recent advances in this area of research and discusses the possible directions for the future research. Part two is an empirical paper presenting a validation of the English version of the Schizophrenia Communication Disorder Scale (SCD). SCD is a clinical scale designed to quantify communication deficits in schizophrenia by assessing the underlying deficits of language disorder in schizophrenia, as demonstrated by electrophysiological findings presented in the review paper. Specifically, the SCD measures contextual information processing and theory of mind abilities. The original version was published in French, and we aimed to translate the scale in to English and provide the preliminary findings on the reliability and validity of the English version. Additionally, SCD data for a healthy control sample has been presented for the first time. Part three includes my personal reflections going through the experience of research. It also includes a critical appraisal of the research project.
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Even, Virginie Roux-Fouillet Jean-Paul. "La valorisation des périodiques électroniques au SCD de Bretagne occidentale." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/ppp/pppeven.pdf.
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Melo, Jussara Costa. "Estudo empírico sobre a proposta do serviço de comunicações digitais - SCD." reponame:Repositório Institucional da UnB, 2012. http://repositorio.unb.br/handle/10482/11414.
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Orientação: Carlos Eduardo Machado da Costa Esch.Dissertação (mestrado)—Universidade de Brasília, Faculdade de Comunicação, Programa de Pós-Graduação em Comunicação, 2012.
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No ano de 2003 a Agência Nacional de Telecomunicações – Anatel adotando como premissa a migração dos serviços de telecomunicações para os serviços de acesso à informação lançou a proposta de criação do Serviço de Comunicações Digitais – SCD que permitiria o acesso às redes digitais e à Internet, o que representaria a ação efetiva do Estado para promover a inclusão digital, a cidadania, garantir o direito de acesso à informação, atender às demandas sociais previstas na Lei do Fundo de Universalização dos Serviços de Telecomunicações (FUST) e cumprir os propósitos da Cúpula Mundial da Sociedade da Informação realizada em Genebra em 2003. A proposta não avançou e o novo serviço não foi criado. Esta dissertação analisa as contribuições às consultas públicas relativas à proposta do novo serviço a fim de proporcionar uma reflexão acerca das tendências e possíveis causas indicativas da opção pela não criação do SCD. _________________________________________________________________________________________________ ABSTRACT
In 2003, the National Telecommunications Agency – Anatel, launched a proposal for the creation of a new digital communications service, designated as SCD which would allow the access to digital networks and to the Internet would represent an effective State action towards the promotion of digital inclusion, citizenship, legal right to information access, provide social demands foreseen by the universalization law and would also accomplish the purposes established by the World Summit of Information Society held in Geneva in 2003. Nevertheless, the proposal did not succeded. This research analyses the comments and opinions expressed within the public consultations processes in an attempt to identify reasons, tendencies and causes that justify the decision not to create de new service.
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Beurton, Ginette Ducharme Christian. "Extension de l'intranet documentaire du SCD de l'Université d'Evry-Val-d'Essonne." [S.l.] : [s.n.], 2002. http://www.enssib.fr/bibliotheque/documents/ppp/ppp-beurton.pdf.
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Mattox, Cassie. "Examination of auxin transport and root development in the scd1-1 mutant in Arabidopsis thaliana." Winston-Salem, NC : Wake Forest University, 2009. http://dspace.zsr.wfu.edu/jspui/handle/10339/42592.
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Sorice, Andréia Fátima. "Análise da evolução de longo prazo das temperaturas do satélite SCD-1." Instituto Tecnológico de Aeronáutica, 2007. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=389.
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O objetivo desta dissertação de mestrado é investigar as causas da elevação da temperatura do satélite SCD-1 (Satélite de Coleta de Dados) ao longo dos seus 13 anos em órbita. O SCD-1 é o primeiro satélite projetado e construído no Brasil, lançado com sucesso em 1993, e ainda em operação. O controle térmico foi realizado por meio passivo usando tintas, isolantes térmicos e materiais condutivos, apropriados para manter as temperaturas do satélite em níveis especificados. Um modelo matemático foi desenvolvido para simular o comportamento térmico do SCD-1 em órbita, sendo utilizado como ferramenta de trabalho durante a fase de projeto. As temperaturas em órbita, de trinta componentes do SCD-1, foram monitoradas e registradas no Centro de Controle e Rastreio (São José dos Campos - SP) desde o seu lançamento. Uma análise feita no início da missão mostrou que todas as temperaturas estavam nas faixas previstas pelo modelo e, ao longo destes 13 anos, a bateria, que é o equipamento mais sensível termicamente, apresentou um aumento de temperatura alcançando seu limite máximo aceitável. Desenvolveu-se uma metodologia para investigar as causas deste desvio. Uma rotina de otimização, acoplada ao modelo matemático, foi utilizada para corrigir um conjunto de parâmetros selecionados do modelo de forma a ajustar as temperaturas teóricas às de vôo. Por meio desta metodologia, analisaram-se os dados do SCD-1 no período compreendido entre 1995 e 2005 e conclui-se que a elevação da temperatura foi causada principalmente pelo aumento da dissipação interna de calor da bateria, conseqüência da degradação ao longo de sua vida orbital. Os resultados desta investigação podem ser úteis no desenvolvimento de outros satélites no sentido de alertar quanto as possíveis causas dos desvios de longo prazo e considerá-los nas análises de novos projetos para obtenção de modelos mais precisos.
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Caron, Valérie. "Formation et autoformation des usagers au SCD de l'Université de la Réunion." [S.l.] : [s.n.], 2002. http://www.enssib.fr/bibliotheque/documents/dcb/rscaron.pdf.
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Lobet, Jean-Luc Chartron Ghislaine. "Evaluer l'utilisation de la collection électronique l'exemple du SCD de Lyon 2 /." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/dcb/lobet.pdf.
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Orain, Christine Collinot Anne. "LMD et politique documentaire exemple du SCD de l'Université de Rennes 2 /." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/dcb/orain.pdf.
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Smouts, Marie. "La communication interne en bibliothèque l'exemple du SCD de l'Université Lyon I /." [S.l.] : [s.n.], 2003. http://www.enssib.fr/bibliotheque/documents/dcb/smouts.pdf.
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Lehmann, Anna [Verfasser]. "Genotyp-spezifisches Fortschreiten der Atrophie ist sensitiver als klinische Veränderungen bei SCA3 und SCA6 / Anna Lehmann." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1056826886/34.
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Pinnameneni, Srijan Kumar, and s3083722@student rmit edu au. "Role of stearoyl-CoA desaturase1 in fatty acid-induced insulin resistance." RMIT University. Medical Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20070119.162450.
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Recent investigations suggest that reducing stearoyl CoA desaturase (SCD) 1 expression confers protection against obesity and insulin resistance, whereas others show that increasing SCD1 expression protects cells from lipotoxicity. The overall aim of this thesis was to establish the role of SCD1 expression in fatty acid metabolism and insulin stimulated glucose disposal in skeletal muscle. In vitro and in vivo studies were conducted to investigate the relationship between fatty acid subtype, SCD1 expression and fuel metabolism. The role of fatty acid subtype on fatty acid metabolite accumulation and insulin resistance was initially examined in rats. Rats were provided with a low fat diet or a high fat diet consisting of predominantly saturated (SAT) or polyunsaturated fatty acids (PUFA). Rats fed a SAT diet were insulin resistant and had increased skeletal muscle diacylglycerol content whereas rats fed a PUFA diet retained insulin sensitivity and accumulated triacylglycerol rather than diacylglycerol. Interestingly, SCD1 mRNA and protein content were elevated in SAT rats compared with PUFA fed and control fed rats, indicating a possible involvement of SCD1 in the aetiology of insulin resistance. Subsequently, SCD1 expression was examined in the skeletal muscle of various rodent models of genetic and diet-induced obesity. SCD1 content was consistently upregulated in the skeletal muscle of obese rodents. To determine whether SCD1 contributes to or protects from fatty-acid induced insulin resistance, SCD1 levels were transiently altered in L6 skeletal muscle myotubes. Short interfering (si) RNA was used to decrease SCD1 content and a pcDNA3.1/HygromSCD1 vector was introduced to increase SCD1 content. Reducing SCD1 protein resulted in marked esterification of exogenous fatty acids into diacylglycerol and ceramide. Insulin-stimulated Akt (acute transforming retrovirus thymoma) phosphorylation and 2-deoxyglucose uptake were reduced with SCD1 siRNA. Exposure of L6 myotubes to palmitate abolished insulin-stimulated glucose uptake in both control and SCD1 siRNA myotubes. Transient overexpression of SCD1 resulted in triacylglycerol esterification but attenuated ceramide and diacylglycerol accumulation and protected myotubes from fatty acid-induced insulin resistance. Further, these changes were associated with reduced phosphorylation of c-Jun Amino-Terminal Kinase (JNK) and the inhibitor of IêB kinase (IKK), both of which impair insulin signalling. These studies indicated that SCD1 protects from cellular toxicity in L6 myotubes by preventing excessive accumulation of bioactive lipid metabolites. Collectively, these experiments indicate that increasing SCD1 expression may be a protective mechanism designed to prevent insulin resistance in obese phenotypes.
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Gronychová, Gabriela. "Globální talent management ve společnosti Schindler." Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-201730.
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The Master thesis Global talent management in Schindler Company aims to map the concept of the career programme in Schindler Company SCDP (Schindler Career Development Programme) and to assess the feedback of programme participants based on the survey among participants. The thesis is divided into three parts. The first part of the thesis consists of theoretical knowledge on talent management and work with talents. Basic and key terms that are crucial for deeper introduction to the topic are defined in this part as well. The second part already has a practical character and it is dedicated to the program. Its particular phases, objectives and specifics are defined. The research part is based on the survey completed by participants of the programme. The programme is assessed based on the evaluation of the survey and recommendations for its improvement are proposed. The benefit of this thesis is the provision of survey results and recommendations for programme improvements, which can help Schindler with better understanding on their talents´ attitude.
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Chang, Ya-Ju [Verfasser], Matthias [Akademischer Betreuer] Finkbeiner, Matthias [Gutachter] Finkbeiner, and Marzia [Gutachter] Traverso. "The Sustainable Child Development Index (SCDI) / Ya-Ju Chang ; Gutachter: Matthias Finkbeiner, Marzia Traverso ; Betreuer: Matthias Finkbeiner." Berlin : Technische Universität Berlin, 2018. http://d-nb.info/1168324149/34.
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Tiittanen, Anni, Camilla Orre, and Maryana Isaac. "En prövning av föräldraskattningsformuläret SCDI-III på somaliska : Svårigheter med att översätta frågeformulär till ett nytt språk." Thesis, Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-168139.
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Under de senaste trettio åren, har antalet flerspråkiga individer ökat i Sverige betydligt. Antalet flerspråkiga barn i behov av en noggrann språklig undersökning är därmed stort. Det råder dessutom en generell brist på språkliga bedömningsmaterial för flerspråkiga barn i Sverige. Somalier utgör en stor del av den flerspråkiga gruppen i Sverige, vilket motiverar behovet av ett språkligt instrument för denna population. En översättning till somaliska av föräldraskattningsformuläret The Swedish Communicative Development Inventory (SCDI-III) har därför skapats. SCDI-III är en anpassning av MacArthur-Bates Communicative Development Inventory (MB-CDI) och är utformat för att via föräldraskattning undersöka tal- och språkförmågan hos barn mellan 2;6–4;0 år. Ett antal språkspecifika korrigeringar har gjorts från svenska SCDI-III till den somaliska versionen för en bättre anpassning till det somaliska språket. Syftet med föreliggande studie var att pröva den somaliska översatta versionen av SCDI-III. Totalt tio somalisktalande vårdnadshavare inkluderades i studien. Deltagarna rekryterades via barnavårdscentraler, förskolor samt genom privata kontakter. Resultatet i föreliggande studie visar att deltagarnas inlämnade frågeformulär var ofullständigt ifyllda. Ingen samstämmighet avseende vilka sektioner av instrumentet som inte besvarades kunde iakttas. Dessutom noterades inga korrelationer mellan bakgrundsvariablerna och hur vårdnadshavarna svarade. På grund av det låga deltagarantalet, i kombination med ovan nämnda faktorer, kan inga slutsatser om huruvida instrumentet är användbart för gruppen somaliska vårdnadshavare i Sverige dras. Sannolikt behöver instrumentet revideras och prövas igen, innan det kan användas kliniskt.Over the last thirty years the number of multilingual individuals has significantly increased in Sweden. Consequently, there are several multilingual children in need of a detailed language assessment. At the same time, there is a general lack of tools for assessing speech and language in multilingual children in Sweden. People from Somalia are a substantial part of the multilingual community in Sweden, which motivates a need for a language assessment tool for this population. A translation of the parent-report instrument The Swedish Communicative Development Inventory (SCDI-III) to Somali has been made. The SCDI-III is an adapted version from the MacArthurBates Communicative Development Inventory (MB-CDI). The instrument is designed to investigate the speech and language ability of children between 2;6–4;0 years via parental reports. In order to develop a better adaption to the Somali language, a number of language-specific revisions have been made from the Swedish SCDI-III to the Somali version. The aim of the current study was to evaluate the Somali translated version of SCDIIII. A total of ten Somali-speaking caretakers were included in the study. The participants were recruited through child-care centers, preschools and private contacts. The results of the present study show that the participants' submitted questionnaires were incomplete. No common patterns as to which sections that were incomplete could be identified, nor could any correlations between any of the background information items and incomplete sections be found. Due to the low number of participants, in combination with the above-mentioned factors, no conclusions can be drawn as to whether the instrument is applicable for the group of Somali caretakers in Sweden or not. The instrument is likely in need of a revision, and a thorough pre-test before it can be implemented clinically.
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Czernielewski, Cyril Ollès Christian. "La numérisation des collections patrimoniales imprimées et iconographiques du SCD de Montpellier 2." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/ppp/pppczernielewski.pdf.
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Chen, Lijun. "SUMMARITIVE DIGEST FOR LARGE DOCUMENT REPOSITORIES WITH APPLICATION TO E-RULEMAKING." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1189038245.
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Vaquero, Camila Gabriela Pereira. "Influência de etossulfato de fenazina na produção in vitro de embriões bovinos, gestação e na expressão gênica da via do metabolismo do triacilglicerol." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/74/74135/tde-05102015-092328/.
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A produção in vitro (PIV) de embriões tem sido utilizada amplamente no Brasil como ferramenta para acelerar o melhoramento genético do rebanho. Quando associada à criopreservação, a PIV permite maior flexibilidade da biotecnologia e possibilita estabelecer um banco de embriões. Há a possibilidade que a alta sensibilidade à criopreservação dos embriões bovinos seja influenciada principalmente pela grande quantidade de lipídeos intracitoplasmáticos, sendo isso relacionado especialmente às condições de cultivo in vitro. O Etossulfato de Fenazina (PES) consiste em um regulador do metabolismo de lipídeos. Através da oxidação de NADPH, estimula a via da pentose-fosfato e assim inibe a síntese de ácidos graxos, podendo levar a efeitos benéficos na criopreservação de embriões bovinos produzidos in vitro. O Fator de transcrição denominado proteína de ligação do elemento regulatório de esterol (SREBP-1c), regula preferencialmente a transcrição de genes da síntese de triacilglicerol e fosfolipídios e, a enzima Estearoil Co-A desaturase (SCD1) promove a síntese de ácidos graxos monoinsaturados, conferindo fluidez às membranas celulares. O objetivo desse trabalho foi avaliar a suplementação de diferentes concentrações do etossulfato de fenazina (PES) no meio de cultivo, durante a produção in vitro de embriões bovinos, e verificar o efeito do PES na taxa de gestação, buscando melhorar a qualidade do embrião para a criopreservação através da redução do acúmulo de lipídeos. Foram avaliadas as taxas de desenvolvimento inicial de embriões produzidos in vitro provenientes de ovários de abatedouro, e as taxas de gestação com o uso de embriões bovinos produzidos in vitro a partir da Aspiração folicular de vacas Holandesas e vitrificados. A análise da expressão de genes relacionados com biossíntese de triacilglicerol, SCD1 e SREBP-1c, teve como finalidade auxiliar nos conhecimentos básicos dos mecanismos de ação do Etossulfato de Fenazina, e foi realizada através de PCR quantitativo em Tempo Real, utilizando pools de cinco embriões para cada grupo. Para a análise estatística, foi realizada ANOVA seguida de teste de médias, e o teste qui-quadrado para as taxas de gestação. Não houve diferença estatística na taxa de clivagem e blastocisto entre o grupo controle e os grupos tratados com 0,2µM; 0,3µM; 0,5µM de PES no meio de cultivo in vitro. A taxa de gestação, utilizando-se embriões criopreservados, transferidos para receptoras, não foi alterada pelo uso de PES. A expressão tanto do SREBP-1c, quanto da SCD1 manteve níveis similares na presença ou ausência de PES durante o cultivo in vitro. Sendo assim faz-se necessário novos estudos para investigar mais detalhadamente o mecanismo de ação do PES nos genes da via de biossíntese de lipídeos e se é viável sua utilização a campo.The in vitro production (IVP) of embryos has been widely used in Brazil as a tool to accelerate the genetic breeding. When combined with cryopreservation, the IVP allows greater flexibility of biotechnology and enable to establish a bank of embryos. There is a possibility that the greater sensitivity to cryopreservation of bovine embryos is influenced mainly by the large amount of intracytoplasmic lipids, and that is especially related to in vitro culture conditions. The phenazine ethosulfate (PES) consists of a lipid metabolism regulator. By NADPH oxidation, stimulates the pentose-phosphate pathway and thus inhibits the fatty acids synthesis, leading to beneficial effects on cryopreservation of bovine embryos in vitro produced. The transcription factor called sterol regulatory element binding proteins (SREBP-1c), preferably regulates the gene transcription of phospholipids and triacylglycerol synthesis and the stearoyl-Co A desaturase (SCD1) enzyme promotes the monounsaturated fatty acids synthesis, giving fluidity to cell membranes. The aim of this study was to evaluate the supplementation of different concentrations of phenazine ethosulfate (PES) in the culture medium during in vitro production of bovine embryos, and determine the effect of PES in the pregnancy rate, aiming to improve the the embryo quality to cryopreservation by reducing the lipids accumulation. We evaluated the early development rates of in vitro produced embryos and pregnancy rates after inovulation of vitrified in vitro produced embryos derived from the Ovum Pick Up of Holstein cows. Expression analysis of triacylglycerol biosynthesis related genes, SCD1 and SREBP-1c, had the purpose to increase the basic knowledge on phenazine ethosulfate mechanisms of action, and was performed by Quantitative Real-Time PCR using pools of five embryos for each group. For statistical analysis, was performed ANOVA followed by mean test, and the chi-square test for pregnancy rates. There was no statistical difference in the cleavage rate and blastocyst rate between the control group and the groups treated with 0,2µM; 0,3µM; 0,5µM of PES in the medium in vitro culture. The pregnancy rate, using cryopreserved embryos transferred to recipient was not altered by the use of PES. The expression of the SREBP-1c as well as SCD1 remained similar in the presence or absence of the PES during in vitro cultivation. Therefore it is necessary further studies to investigate in more details the PES mechanism of action in the genes of lipid biosynthesis pathway and whether it is feasible to use the field.
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Pham, Timmy. "Trends and outcomes of contemporary catheter ablation for ventricular arrhythmias." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/24978.
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Ventricular arrhythmias (VA); particularly ventricular tachycardia (VT) is the primary cause of sudden cardiac death. Implantable cardioverter-defibrillators and anti-arrhythmic drugs are used to combat disease; however, both therapies cannot cure VT. Recently, catheter ablation (CA) has emerged as a viable procedure for the treatment of VT, especially in significantly reducing recurrent VT burden, hospitalization, and mortality rates. Whilst the evidence supporting the use of CA is increasing, certain areas of literary paucity exist which was addressed in this thesis, including: (i) a pooled review and analysis of published outcomes comparing ischemic cardiomyopathy (ICM) to non-ischemic cardiomyopathy (NICM) patients; (ii) differences between the sexes undergoing CA; (iii) and temporal analysis of procedures between distinct eras. The review and meta-analysis of two decades of published data showed whilst ICM patients were a sicker cohort, procedural success and outcomes were more favourable compared to NICM patients. The findings reverberated the consensus of the challenges when treating NICM patients and the need for further study in this group. Compared to men, women differed in baseline characteristics, procedural outcomes, and follow-up. However, in aetiological subgroup analysis statistical differences were not observed. Indeed, the burden of cardiac diseases remains male dominated, yet women are underrepresented in cardiac studies. These findings outline that CA is equally safe and effective in both sexes, and sex should not be a factor in referrals. Temporal analysis over 12 years, showed procedures had doubled every four years. Improvements in the efficacy of CA emerged in idiopathic VA and ICM patients, but not in NICM patients, despite the increasing number of such patients undergoing CA. Further temporal analysis is critical, especially in this rapidly evolving field
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SILVA, Luciney. "Tomada de decisão na concessão de diárias e passagens por gestores da UFCG: potencialidades e vulnerabilidades do SCDP." Universidade Federal de Campina Grande, 2018. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/1639.
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Decidir é uma constante durante toda a vida de qualquer pessoa e com o avanço das ciências da Administração, a Tomada de Decisão ganhou notoriedade. As Instituições de Ensino Superior são organizações complexas e extremamente relevantes para a sociedade moderna. Analisar aspectos administrativos de uma organização de natureza pública é além de enriquecedor, necessário, pois são mantidas por recursos públicos cada vez mais escassos. O uso dos sistemas de informações permite que o erário público seja melhor gerido. Nesse contexto, o presente estudo buscou analisar até que ponto o Sistema de Concessão de Diárias e Passagens auxilia os ordenadores de despesas da Universidade Federal de Campina Grande no processo de tomada de decisão na concessão de diárias e passagens. Quanto a metodologia, trata-se de uma pesquisa qualitativa e estudo de campo, exploratório-descritiva que coletou os dados através de um questionário aplicado aos ordenadores de despesas, para realizar uma análise temática e categorial dos dados. A apreciação dos resultados possibilitou traçar o perfil dos ordenadores de despesas da UFCG, e confirmar que os mesmos utilizam relatórios e dados gerenciais do SCDP no processo decisório. Ao descobrir a maneira que os gestores priorizam as concessões de viagens, foi proposta uma lista de prioridades que pode ser aplicada na instituição. Os modelos de tomada de decisão preponderantes, reaplicando os estudos de estudos correlatos de Leitão (1991), Simão (2001) e Sorgetz (2016), foram o Burocrático e Colegiado. O potencial de Sistema de Apoio à Decisão do SCDP é reconhecido pelos decisores, embora ainda não exista a implantação do perfil operacional na instituição. Apesar de menosprezar esse potencial, conclui-se que o SCDP auxilia o processo decisório dos ordenadores de despesa ao conceder diárias e passagens e mesmo com predominância, não há modelo capaz de sozinho, contemplar todo processo de tomada de decisão. Recomenda-se estudos futuros em instituições com o módulo de apoio a decisão do SCDP implantado para confrontar com este estudo ou ratificar o entendimento comportamental do processo decisório na concessão de diárias e passagens em IES públicas.
Deciding is a constant throughout the life of any person and with the advancement of the Management sciences, Decision Making has gained notoriety. Higher Education Institutions (HEI) are complex and extremely relevant organizations for modern society. Analyzing administrative aspects of an organization of a public nature is beyond enriching, necessary, as they are maintained by increasingly scarce public resources. The use of information systems allows the public treasury a better managed. In this context, the present study sought to analyze the extent to which the Sistema de Concessão de Diárias e Passagens (Daily Travel Allowance System - SCDP) helps the managers of the Universidade Federal de Campina Grande (Federal University of Campina Grande - UFCG) in the decision-making process in the concession of daily travels and tickets. As for the methodology, this is a qualitative research and field study, exploratory-descriptive that collected the data through an evaluation questionnaire applied to the expenses administrators, to perform a thematic and categorical analysis of the data. The results analyze made it possible to trace a profile of the UFCG's expenses administrators and confirm that they use reports and management data from the SCDP in the decision-making process. By discovering how managers prioritize travel grants, a list of priorities that can be applied at the institution has been proposed. The prevailing decision-making models, re-applying the related studies of Leitão (1991), Simão (2001) and Sorgetz (2016), were the Bureaucratic and Collegiate. Decision-makers recognize the potential of the SCDP like a Decision Support System, although the operational profile has not been implemented in the institution yet. Although this potential is underestimated, it can be concluded that the SCDP assists the decision-making process of the managers granting daily travels and tickets, even with predominance, there is no model capable of alone, contemplating every decision-making process. Recommend future studies in institutions with the SCDP decision support module deployed to confront this study or ratify the behavioral understanding of the decision-making process in the granting of diaries and passages in public HEIs.
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Morlat, Isabelle. "La formation des usagers à Paris IV complémentarité des actions entre SCD et Université /." [S.l.] : [s.n.], 2003. http://www.enssib.fr/bibliotheque/documents/dcb/morlat.pdf.
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Emmel, Vanessa Erichsen. "Análise de repetições CAG nos genes SCA1, SCA2, SCA3 e SCA6 em pacientes com suspeita clínica de ataxia espinocerebelar." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/10967.
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As ataxias espinocerebelares (SCAs) são doenças neurodegenerativas com herança autossômica dominante que apresentam grande heterogeneidade clínica e genética. O diagnóstico é realizado pela detecção da mutação no gene causador, que, na sua maioria, é uma expansão de repetições trinucleotídicas CAG. O objetivo deste estudo foi analisar os polimorfismos de repetições trinucleotídicas nos genes associados as SCAs tipo 1, tipo 2, tipo 3 e tipo 6 através de PCR-multiplex e eletroforese capilar, visando a melhoria do diagnóstico molecular e a determinação da distribuição das regiões polimórficas nos alelos normais. As análises foram realizadas em 124 pacientes não-aparentados que apresentavam sintomas de ataxia. Nessa amostra, foram identificados 10 pacientes com SCA2, 39 pacientes com SCA3 e 2 pacientes com SCA6. Não encontramos amostras com uma expansão CAG no gene SCA1. Os polimorfismos de cada loci foram estudados nos cromossomos normais desses pacientes (n=209-248). A freqüência dos alelos normais grandes no locus SCA1 (>32 repetições CAG) foi estabelecida em 0,05 e no locus SCA2 (>22 repetições CAG) foi 0,11, enquanto que no locus SCA3 (alelos >28 repetições) a freqüência foi 0,11. A freqüência de alelos normais grandes para o locus SCA6 (>13 repetições) foi 0,04. Concluindo, este estudo proporcionou a primeira análise detalhada da distribuição de repetições CAG nos loci SCA1, SCA2, SCA3 e SCA6 por amplificação multiplex e eletroforese capilar em pacientes brasileiros. A freqüência dos alelos normais grandes nos genes SCA3 e SCA6 nessa amostra reflete a prevalência destas duas doenças na nossa população, concordando com a hipótese que alelos patogênicos podem ser originados pela expansão de alelos normais grandes.Spinocerebellar ataxias (SCAs) are neurodegenerative disorders inherited as an autosomal dominant trait that present large genetic and clinical heterogeneity. An accurate diagnosis relies on mutation detection in a specific causative gene, which is typically an abnormal number of CAG trinucleotide repeats. The aim of this study was to analyze polymorphic regions of trinucleotide repeats in SCA1, SCA2, SCA3, and SCA6 associated genes through multiplex PCR and capillary electrophoresis, aiming the improvement of molecular diagnosis and distribution of CAG repeats number in normal alleles. Analyses were carried out in 124 unrelated Brazilian patients who presented symptoms of progressive ataxia. To date, we identified 10 patients with SCA2, 39 patients with SCA3, and 2 patients with SCA6. No alleles were identified with a CAG expansion tract in the SCA1 gene. Normal CAG repeats length range was established using data from normal chromosomes (n=209-248). Frequency of large normal alleles in SCA1 locus (>32 CAG repeats) was determined to be 0.05. Frequency of large normal alleles at the SCA2 locus (>22 CAG repeats) was shown to be 0.11 while at the SCA3 locus (>28 CAG repeats) frequency of large normal alleles was 0.11. At the SCA6 locus, frequency of large normal alleles (>13 CAG repeats) was found to be 0.04. Moreover, this study provides the first detailed analysis, to our knowledge, of the distribution of CAG repeats at the SCA1, SCA2, SCA3, and SCA6 loci by multiplex-PCR and automated capillary electrophoresis in Brazilian patients. Frequency of large normal alleles in SCA3 and SCA6 genes established in this sample reflects the prevalence of these two diseases in our population, supporting the hypothesis that disease alleles emerge from expansion of large normal alleles.
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Bruley, Caroline. "Le site Web du SCD comme outil de distribution de la documentation électronique de l'université." [S.l.] : [s.n.], 2003. http://www.enssib.fr/bibliotheque/documents/dcb/bruley.pdf.
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Rosier, Fabienne Gilardi-Monnier Marinette. "Implanter un service de référence au SCD de l'Université Robert Schuman enjeux, atouts et contraintes /." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/dcb/rosier.pdf.
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Simon, Sophie Ollès Christian Maniez Dominique. "Proposer des livres électroniques à la Section sciences du SCD de l'Université Paris-Sud 11." [S.l.] : [s.n.], 2006. http://www.enssib.fr/bibliotheque/documents/ppp/ppp-simon-N.pdf.
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Skvortsova, Mariya. "Investigating the biosynthesis of cuticular alkanes in Arabidopsis thaliana : Characterization of SCD2 and chemical analysis of double CER mutant waxes." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44184.
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The plant cuticle is a hydrophobic layer that seals the surface of primary aerial organs of terrestrial plants and serves in protecting the tissues from abiotic and biotic stresses. Lipids are synthesized in the plastid and in the endoplasmic reticulum (ER) of epidermal cells for eventual export and deposition on the surface. Great progress has been made by genetic studies in the model plant Arabidopsis thaliana in elucidating fatty acid elongation, but knowledge of alkane biosynthesis is still scarce. The current work was focused on expanding our current understanding of alkane biosynthesis in Arabidopsis thaliana. A recent discovery of Susceptible to Coronatine-Deficient Pst DC3118-2 (SCD2) whose mutant has a leaf-specific increase in aldehydes and a decrease in alkanes suggests that SCD2 has a role in converting aldehydes to alkanes. In this thesis, further characterization of SCD2 revealed that alkanes are decreased in two mutant lines, the wax of mutants was restored by transgene complementation with the native gene, the transcript is abundant in leaves, and the promoter is active in the phloem of vasculature. Finally, the protein localized to the ER, consistent with its role in wax biosynthesis. This work provided evidence for yet another gene whose product is involved in formation of cuticular alkanes in Arabidopsis thaliana.
Double mutants were generated to further study wax biosynthesis in both stems and leaves. The cer1cer3 mutant had greatly reduced total stem and leaf wax amounts compared to wild-type, as well as a substantial reduction of alkanes. It has an increase in C30 primary alcohol levels like the cer3 parent, indicating epistasis. This suggests that CER3 precedes CER1 in alkane formation. Furthermore, it is severely male-sterile with a reduction in epicuticular wax crystals. Wax biosynthesis is similar in stems and leaves of cer1cer3, cer1cer4 and cer3cer4. The cer1cer3 will be an important tool to test domain functionality of CER1 and CER3 and may shed more light on the mechanisms of alkane formation in Arabidopsis thaliana.
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Ren, Jun. "Isolation and molecular characterization of the stearoyl-CoA desaturase (SCD) gene affecting fat deposition in pigs." Doctoral thesis, [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/ren/ren.pdf.
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Besse, Claire Lancha Catherine. "Elaboration d'une politique documentaire pour les périodiques du SCD de l'Institut de formation des maîtres d'Aquitaine." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/ppp/pppbesse.pdf.
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Momein, Ingrid Laroux Marie-Noëlle. "La création d'une bibliothèque universitaire délocalisée par l'intégration de bibliothèques associées l'exemple de Bourges (SCD d'Orléans) /." [S.l.] : [s.n.], 2001. http://www.enssib.fr/bibliotheque/documents/ppp/ppp-momein.pdf.
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Guilleray, Pierre Emmanuel. "Projet de catalogue collectif virtuel accessible par le client Z39.50 du SCD de l'Université Lyon 3." [S.l.] : [s.n.], 2003. http://www.enssib.fr/bibliotheque/documents/dcb/guilleray.pdf.
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Thirion, Gaid Flahaut-Steiner Anne Larouk Omar. "Réinformatisation du SCD de l'Université Lyon 3 proposition de solutions en vue du changement de SIGB /." [S.l.] : [s.n.], 2005. http://www.enssib.fr/bibliotheque/documents/dessride/rsthirion.pdf.
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Béguec, Annelise Mondon Frédérique Charra Gaëlle Houpier Jean-Charles Pelle Marie-Laure Puel Stéphanie Weber Anne. "Conduite et gestion de projet préparation de la réhabilitation de la BU Sciences - SCD Lyon 1 /." [S.l.] : [s.n.], 2006. http://www.enssib.fr/bibliotheque/documents/dcb/M-2005-PRO-14-vol1.pdf.
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Al, Darwich Abdulrahman. "Métabolisme lipidique et cryorésistance des embryons dans l’espèce bovine." Thesis, Tours, 2009. http://www.theses.fr/2009TOUR4031/document.
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Les embryons bovins produits in vitro sont plus sensibles à la cryoconservation que ceux produits in vivo, en partie à cause de leur contenu lipidique, triglycérides et phospholipides. L’objectif de ce travail visait à comprendre les mécanismes moléculaires responsables de cette différence. Le profil transcriptomique de gènes impliqués dans le métabolisme lipidique a été établi. Le niveau d'expression génique de l’adipophiline obtenu indique qu’il peut être un marqueur spécifique de l'accumulation des triglycérides et de la cryorésistance des embryons. Ainsi, l’accumulation des triglycérides pourrait être liée à une absence de dégradation des lipides et non à une synthèse de novo uniquement. L’ajout d’acides gras polyinsaturés, C18:2, C18:3 ou DHA dans le milieu de développement, a régulé l'expression génique de SCD1 et de FADS2, deux enzymes qui désaturent les lipides, et ce, probablement via la régulation de SREBP1, ce qui pourrait être en lien direct avec les modifications de la balance acides gras saturés / insaturés et jouer sur la fluidité membranaire et la cryorésistanceIn vitro produced embryos are more sensitive to cryopreservation than those in vivo derived, partly because of their fat content, triglycerides and phospholipids. The objective of this work was to understand the molecular mechanisms responsible for this difference. mRNA expression of genes involved in lipid metabolism has been established. Results of adipophilin mRNA level indicates that it maybe a specific marker for triglycerides accumulation and embryo cryorésistance. Thus, triglyceride accumulation could be related to a lack of lipids degradation rather than new lipids synthesis only. Polyunsaturated fatty acids supplementation, C18: 2 C18: 3 or DHA in culture media regulated mRNA expression of SCD1 and FADS2, two enzymes involved in lipids desaturation, probably through SREBP1 regulation, which could be directly linked to changes in the balance of saturated / unsaturated fatty acids and could contribute to change membrane fluidity and embryo cryoresistance
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Wiman, Josefin. "Investigation of the intra-day variation in stearoyl-CoA-desaturase activity by measuring the product-to-precursor ratios of fatty acids (16:1/16:0 and 18:1/18:0)." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-87728.
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Obesity is today a problem that has reached epidemic proportions. One of the causes of obesity is the over-consumption of energy. Fat is the most energy-dense nutrient, where the quality seems to be more important for the development of the metabolic diseases than the quantity. The fatty acid composition in serum lipid fractions can be used to mirror the dietary fat quality.
Stearoyl-CoA-desaturase (SCD) is an enzyme that converts saturated to monounsaturated fatty acids. A surrogate measure of SCD activity can be estimated as a fatty acid ratio; 16:1/16:0 (palmitoleic acid/palmitic acid) and 18:1/18:0 (oleic acid/stearic acid). The aim of this project was to investigate the intra-day variation in the SCD-ratio in humans eating a standardized diet. The results showed that triacylglycerol and nonesterified fatty acid fractions in serum lipids had a significant variance in the 16:1/16:0 ratio during the day, whereas 18:1/18:0 ratio in the same fractions did not exhibit the same pattern. In this study 16:1/16:0 ratio also seems to be a better marker than 18:1/18:0 ratio for estimating SCD activity. For further evaluation of the intra-day variation there need to be a more long-term study of the SCD-activity for a larger group of subjects.
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Drognat-Landré, Noëlle. "Conception et réalisation d'un tableau de bord à partir d'indicateurs d'activité pour le SCD de Lyon 1." [S.l.] : [s.n.], 2003. http://www.enssib.fr/bibliotheque/documents/dcb/M-2003-PRO-07-lyon1-vol1.pdf.
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Lobet, Jean-Luc Baude Dominique. "Consolider la collecte des statistiques pour mesurer l'utilisation de la collection électronique au SCD de Lyon 2." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/dcb/rslobet.pdf.
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Coudrin, Delphine Miremont Liliane Desalme Aubierge Kotalska Barbara Pichard Éric. "Mise en œuvre d'un système d'information documentaire au SCD de l'Université de la Méditerranée Aix-Marseille 2." [S.l.] : [s.n.], 2005. http://www.enssib.fr/bibliotheque/documents/dcb/M-2005-PRO-10-vol1.pdf.
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Déage, Marie Macquin Agnès Metzger Jean-Paul. "Quelle politique de désherbage pour la BU Sciences et STAPS du SCD de l'Université de Franche-Comté ?" [S.l.] : [s.n.], 2008. http://www.enssib.fr/bibliotheque-numerique/document-2007.
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Martin, Émilie Balmon Théodora. "Apports de l'automatisation pour des services d'accueil rénovés et étendus au SCD de l'Université de technologies de Troyes." [S.l.] : [s.n.], 2008. http://www.enssib.fr/bibliotheque-numerique/document-2011.
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Projet professionnel personnel de bibliothécaire : gestion de projet : bibliothéconomie : Villeurbanne, ENSSIB : 2008.Texte intégral. Résumé en français et en anglais. Bibliogr. f. 45-46. Index.