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Academic literature on the topic 'Scd6'

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Published: 6 September 2023

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Journal articles on the topic "Scd6"

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Simões, Inês T., Fernando Aranda, Sergi Casadó-Llombart, María Velasco-de Andrés, Cristina Català, Pilar Álvarez, Marta Consuegra-Fernández, et al. "Multifaceted effects of soluble human CD6 in experimental cancer models." Journal for ImmunoTherapy of Cancer 8, no. 1 (March 2020): e000172. http://dx.doi.org/10.1136/jitc-2019-000172.

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BackgroundCD6 is a lymphocyte surface co-receptor physically associated with the T-cell receptor (TCR)/CD3 complex at the center of the immunological synapse. There, CD6 assists in cell-to-cell contact stabilization and modulation of activation/differentiation events through interaction with CD166/ALCAM (activated leukocyte cell adhesion molecule), its main reported ligand. While accumulating evidence is attracting new interest on targeting CD6 for therapeutic purposes in autoimmune disorders, little is known on its potential in cancer. In an attempt to elucidate the in vivo relevance of blocking CD6-mediated interactions in health and disease, we explored the consequences of expressing high circulating levels of a soluble form CD6 (sCD6) as a decoy receptor.MethodsHigh sCD6 serum levels were achieved by using transgenic C57BL/6 mice expressing human sCD6 under the control of lymphoid-specific transcriptional elements (shCD6LckEμTg) or wild type either transduced with hepatotropic adeno-associated virus coding for mouse sCD6 or undergoing repeated infusions of recombinant human sCD6 protein. Characterization of sCD6-induced changes was performed by ex vivo flow cytometry and functional analyses of mouse lymphoid organ cells. The in vivo relevance of those changes was explored by challenging mice with subcutaneous or metastatic tumors induced by syngeneic cancer cells of different lineage origins.ResultsThrough a combination of in vitro and in vivo studies, we show that circulating sCD6 expression induces defective regulatory T cell (Treg) generation and function, decreased CD166/ALCAM-mediated tumor cell proliferation/migration and impaired galectin-induced T-cell apoptosis, supporting the fact that sCD6 modulates antitumor lymphocyte effector function and tumorigenesis. Accordingly, sCD6 expression in vivo resulted in delayed subcutaneous tumor growth and/or reduced metastasis on challenge of mice with syngeneic cancer cells.ConclusionsEvidence is provided for the disruption of CD6 receptor–ligand interactions as a feasible immunomodulatory approach in cancer.
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Krüger, Timothy, Mario Hofweber, and Susanne Kramer. "SCD6 induces ribonucleoprotein granule formation in trypanosomes in a translation-independent manner, regulated by its Lsm and RGG domains." Molecular Biology of the Cell 24, no. 13 (July 2013): 2098–111. http://dx.doi.org/10.1091/mbc.e13-01-0068.

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Ribonucleoprotein (RNP) granules are cytoplasmic, microscopically visible structures composed of RNA and protein with proposed functions in mRNA decay and storage. Trypanosomes have several types of RNP granules, but lack most of the granule core components identified in yeast and humans. The exception is SCD6/Rap55, which is essential for processing body (P-body) formation. In this study, we analyzed the role of trypanosome SCD6 in RNP granule formation. Upon overexpression, the majority of SCD6 aggregates to multiple granules enriched at the nuclear periphery that recruit both P-body and stress granule proteins, as well as mRNAs. Granule protein composition depends on granule distance to the nucleus. In contrast to findings in yeast and humans, granule formation does not correlate with translational repression and can also take place in the nucleus after nuclear targeting of SCD6. While the SCD6 Lsm domain alone is both necessary and sufficient for granule induction, the RGG motif determines granule type and number: the absence of an intact RGG motif results in the formation of fewer granules that resemble P-bodies. The differences in granule number remain after nuclear targeting, indicating translation-independent functions of the RGG domain. We propose that, in trypanosomes, a local increase in SCD6 concentration may be sufficient to induce granules by recruiting mRNA. Proteins that bind selectively to the RGG and/or Lsm domain of SCD6 could be responsible for regulating granule type and number.
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Decker, Carolyn J., and Roy Parker. "CAR-1 and Trailer hitch: driving mRNP granule function at the ER?" Journal of Cell Biology 173, no. 2 (April 24, 2006): 159–63. http://dx.doi.org/10.1083/jcb.200601153.

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The targeting of messenger RNAs (mRNAs) to specific subcellular sites for local translation plays an important role in diverse cellular and developmental processes in eukaryotes, including axis formation, cell fate determination, spindle pole regulation, cell motility, and neuronal synaptic plasticity. Recently, a new conserved class of Lsm proteins, the Scd6 family, has been implicated in controlling mRNA function. Depletion or mutation of members of the Scd6 family, Caenorhabditis elegans CAR-1 and Drosophila melanogaster trailer hitch, lead to a variety of developmental phenotypes, which in some cases can be linked to alterations in the endoplasmic reticulum (ER). Scd6/Lsm proteins are RNA binding proteins and are found in RNP complexes associated with translational control of mRNAs, and these complexes can colocalize with the ER. These findings raise the possibility that localization and translational regulation of mRNAs at the ER plays a role in controlling the organization of this organelle.
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Ramos‐Casals, M., J. Font, M. García‐Carrasco, J. Calvo, L. Places, O. Padilla, R. Cervera, M. A. Bowen, F. Lozano, and M. Ingelmo. "High circulating levels of soluble scavenger receptors (sCD5 and sCD6) in patients with primary Sjögren's syndrome." Rheumatology 40, no. 9 (September 2001): 1056–59. http://dx.doi.org/10.1093/rheumatology/40.9.1056.

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Cristodero, Marina, Bernd Schimanski, Manfred Heller, and Isabel Roditi. "Functional characterization of the trypanosome translational repressor SCD6." Biochemical Journal 457, no. 1 (December 10, 2013): 57–67. http://dx.doi.org/10.1042/bj20130747.

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Trypanosomal SCD6 is a general repressor of translation. It is not required for stress granule formation and, unusually, does not interact with the helicase DHH1. We analysed domains involved in the localization and function of TbSCD6 and identified interacting partners.
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Bhatter, Nupur, Rajan Iyyappan, and Purusharth I. Rajyaguru. "Characterizing mutations in and genetic interactions of RGG-motif translation repressor Sbp1." Wellcome Open Research 3 (August 22, 2018): 102. http://dx.doi.org/10.12688/wellcomeopenres.14709.1.

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Background: Mechanisms of mRNA fate decisions play an important role in determining if a given mRNA will be translated, stored or degraded upon arrival to cytoplasm. Sbp1 is an important RGG-motif containing protein that is implicated in mRNA fate decisions since it can affect mRNA decapping and translation. Sbp1 represses translation by binding eIF4G1 through its RGG-motif and activates decapping when overexpressed. In order to understand the amino acids important for translation repression activity of Sbp1 we performed mutational analysis of Sbp1 combined with assessing its genetic interaction with another RGG-motif protein Scd6. We created two classes of point mutations a) in aromatic residues of the RGG-motif and b) in residues reported to be phosphorylated. Method: Sequence alignment was performed to identify aromatic residues to be mutated based on conservation. Site-directed mutagenesis approach was used to create several point mutations in Sbp1 expressed under galactose-inducible promoter. The mutants were tested for their ability to cause growth defect upon overexpression. The ability of Sbp1 to affect repression activity of other decapping activators was tested using the same growth assay. Results: Mutation of several aromatic residues in the RGG-motif of Sbp1 led to a weak rescue phenotype. However the phospho-mimetic mutants of Sbp1 did not lead to any kind of growth defect rescue. Deletion of another eIF4G1-binding RGG-motif protein Scd6 does not affect ability of Sbp1 to cause growth defect. On the other hand absence of Sbp1 does not affect ability of Dhh1 and Pat1 to repress translation. Conclusion: Based on our growth assay analysis we conclude that mutated aromatic residues contribute marginally to repression activity of Sbp1 whereas phospho-mimetic mutants do not alter ability of Sbp1 to cause growth defect. Interestingly Scd6 does not affect ability of Sbp1 to repress translation, which in turn does not affect Dhh1 and Pat1.
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Poornima, Gopalakrishna, Ravishankar Mythili, Priyabrata Nag, Sabnam Parbin, Praveen Kumar Verma, Tanweer Hussain, and Purusharth I. Rajyaguru. "RGG-motif self-association regulates eIF4G-binding translation repressor protein Scd6." RNA Biology 16, no. 9 (June 12, 2019): 1215–27. http://dx.doi.org/10.1080/15476286.2019.1621623.

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Roy, Debadrita, and Purusharth I. Rajyaguru. "Suppressor of clathrin deficiency (Scd6)-An emerging RGG-motif translation repressor." Wiley Interdisciplinary Reviews: RNA 9, no. 5 (May 22, 2018): e1479. http://dx.doi.org/10.1002/wrna.1479.

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Lien, Pham Thi Kim, Keiichi Izumikawa, Kei Muroi, Kaoru Irie, Yasuyuki Suda, and Kenji Irie. "Analysis of the Physiological Activities of Scd6 through Its Interaction with Hmt1." PLOS ONE 11, no. 10 (October 24, 2016): e0164773. http://dx.doi.org/10.1371/journal.pone.0164773.

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Nocua, Paola A., José M. Requena, and Concepción J. Puerta. "Identification of the interactomes associated with SCD6 and RBP42 proteins in Leishmania braziliensis." Journal of Proteomics 233 (February 2021): 104066. http://dx.doi.org/10.1016/j.jprot.2020.104066.

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Dissertations / Theses on the topic "Scd6"

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Cassafières, Cécile Dalhoumi Salah Fèvre Véronique Jove Camille Lefebvre Pascale Loiselet Martine Elaïdi Claudine. "Formation et évaluation en SCD." [S.l.] : [s.n.], 2005. http://www.enssib.fr/bibliotheque/documents/dcb/M-2005-RECH-02-vol1.pdf.

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Dempsey, Kate E. "Characterisation of a human stearoyl CoA desaturase gene (SCD2)." Thesis, Glasgow Caledonian University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369995.

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CAPUTO, MANUEL. "DEPDC1A, a novel SREBP1 cofactor, regulates fatty acid metabolism in breast cancer." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2924764.

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Breast cancer (BC) figures as the most frequently diagnosed and the leading cause of cancer-related deaths among women worldwide. Despite considerable progress has been made in cancer detection and therapy assignment, several BCs become resistant to therapy and, moreover, a considerable proportion of patients develops metastasis during therapy or experiences relapse. Growing body of evidence indicates that alterations in tumour metabolism are linked to therapeutic resistance, tumour relapse and dissemination. These altered metabolic traits are caused by genetic alterations and environmental factors. The most frequently mutated gene in BC is the tumor suppressor TP53, a well-characterized transcription factor, which plays a central role in cellular homeostasis and prevention of tumour growth. In BC missense mutations occur very often in its DNA binding domain, providing neomorphic mutant p53 proteins that lose the wildtype onco-suppressive functions and acquire instead new oncogenic properties (Gain-of-Function). Indeed, mutant p53 proteins establish aberrant interactions with different transcription factors, thus inducing oncogenic transcriptional programs and metabolic reprogramming. Our previous work outlined a mutant p53 driven signature that promotes aggressiveness in BC in which DEP domain containing 1A (DEPDC1A) emerged as an important mediator of migration and invasiveness (Girardini et al., 2011). DEPDC1A expression is almost undetectable in normal cells, but it is overexpressed in different cancers and its overexpression is associated with poor prognosis. DEPDC1A is a transcriptional cofactor that exists in two different splice variants V1 and V2, but its role in oncogenesis, as well as in a physiological context, remains elusive. Here we show, through a high-throughput transcriptional analysis, that DEPDC1A is able to impinge on lipid metabolism. In particular we observed that mRNAs belonging to the fatty acids biosynthesis pathway genes ATP-Citrate Lyase (ACLY), Stearoyl-CoA Desaturase 1 (SCD1) and Elongation Of Very Long Chain Fatty Acids 6 (ELOVL6) were consistently downregulated upon DEPDC1A silencing suggesting a key role for this factor in controlling fatty acid metabolism in cancer cells. Indeed, ablation of DEDPC1A caused a significant decrease of lipid droplets content and fatty acid desaturation in MDA-MB-231 cell line. ACLY, SCD1 and ELOVL6, as a part of fatty acids biosynthesis pathway, are specific targets of Sterol Regulatory Element Binding Protein (SREBP) transcription factors, master regulators of lipid metabolism. Interestingly, protein co-immunoprecipitation and Chromatin Immunoprecipitation assays demonstrated that DEPDC1A physically interacts with SREBP1 and that it is required for an efficient transcriptional activation of this particular subset of genes, thus acting as transcriptional cofactor of SREBP1. Finally, we showed that DEPDC1A, through SCD1 upregulation, is able to promote aggressive phenotypes, such as migration, and that DEPDC1A overexpression in normal cells is sufficient to induce sensitization toward SCD1 inhibition. This study unveils a novel oncogenic transcriptional program induced by the aberrant interaction between DEPDC1A and SREBP1 transcription factor that is able to induce fatty acid biosynthesis and desaturation in cancer cells and to establish a metabolic addiction that can be potentially exploited in cancer therapy.
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Lundö, Emma, and Sara Norrman. "Ett förslag på hur föräldraskattningsinstrumentet SCDI-III kan valideras : en pilotstudie." Thesis, Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-176308.

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I denna studie ett förslag till validering av föräldraskattningsformuläret SCDI-III baserad på en genomförd pilotstudie. Studiens syfte är att undersöka hur väl föräldrars och förskolepedagogers skattning av deltagande barns språkförmåga med skattningsinstrumentet SCDI-III överensstämmer med resultaten av ett test som studieförfattarna utformade. Testmaterialet speglar direkt de frågor som ställs till vårdnadshavarna och förskolepedagoger i SCDI-III.  Tio barn i åldersgruppen 2;5–3;10 år med svenska som starkaste språk, tio vårdnadshavare och tio förskolepedagoger deltog i studien. Studieförfattarna utformade ett eget testmaterial som i så hög grad som möjligt speglar frågeställningarna i föräldraskattsformuläret SCDI-III. Bildbenämning användes för ordförrådsdelen och BUSS-sagan användes för bedömning av meningskomplexitet och meningsbyggnad. Testningen av sju av barnen utfördes i det digitala mötesrummet Zoom och tre barn testades delvis på förskolan. Vårdnadshavarna och förskolepedagogerna fyllde i föräldraskattningsformuläret SCDI-III, varefter resultaten jämfördes.   Resultatet visade generellt på en hög överensstämmelse mellan samtliga bedömargrupper. Det förelåg endast små skillnader mellan grupperna och dessa var förutom två ord (“förstå” och “dum”) inte statistiskt signifikanta.   Slutsatsen var att deltagande vårdnadshavare och förskolepedagoger kunde skatta barnens språkliga förmåga i hög utsträckning. Studiens resultat pekar därmed på att föräldraskattningen SCDI-III kan vara värdefull som kompletterande information gällande barnets språkliga förmåga. Förslag på hur en större valideringsstudie kan genomföras diskuteras.
In the present study, a suggestion is provided of how the parent report instrument, The Swedish Communicative Development Inventories (SCDI-III) can be validated. The suggestion is based on a conducted pilot study. The purpose of the study is to investigate how well parents and preschool teachers assessment of participating children’s language ability with the assessment instrument SCDI-III corresponds with the results of a test designed by the study authors. The test material directly reflects the questions asked to the guardians and preschool teachers in SCDI-III.  Ten children in the age group 2;5-3;10 years old with Swedish as their strongest language, ten guardians and ten preschool teachers participated in the study. The study authors designed a test material which as closely as possible mirrored the content in the questions asked in the parent report SCDI-III. Picture-naming was used for the vocabulary part and the BUS-story test was used for the assessment of sentence complexity and sentence construction. The screening of seven of the children was performed in the digital meeting room Zoom, and three children were partially tested at the preschool. The guardians and preschool teachers filled in the parent report SCDI-III, and the results were compared.   The results generally showed a high degree of agreement between all the assessment groups. There were only small differences between the groups and these, apart from two words ("understand" and "stupid") were not statistically significant.   The conclusion was that participating guardians and preschool teachers could estimate the children’s language ability to a great extent. The results of the study indicate that the parent report SCDI-III, can be valuable as supplementary information regarding the children’s language ability. Suggestions on how a larger validation study may be carried out are discussed.
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Gaillard, Béatrice Duchemin Pierre-Yves. "Organiser la gestion des ressources électroniques dans un SCD de Sciences Humaines et Sociales le cas du SCD de Lyon 2 /." [S.l.] : [s.n.], 2005. http://www.enssib.fr/bibliotheque/documents/dcb/gaillard.pdf.

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Odeskog, Sanna, and Noomi Stenberg. "Validering av föräldraskattningsformuläret SCDI-III för svenska barn i tre års ålder." Thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-118710.

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Föräldraskattningsformuläret The Swedish Communicative Development Inventory (SCDI-III) är en modifierad form av MacArthur-Bates Communicative Development Inventorys tredje form (CDI-III), och har tagits fram som ett forskningsinstrument för undersökning av språkförmågan hos barn i åldersgruppen 2;6-4;0 år. Det är av stor betydelse att barn i riskzonen för att utveckla en språkstörning upptäcks i tid för att språket ska kunna stimuleras under gynnsamma utvecklingsfaser. Kliniskt verksamma personer har givit uttryck för ett behov av ett material som kan ge en överblick av ett barns språkförmåga inför vidare språkutredning. Behovet av ett sådant material bidrog till att validiteten hos SCDI-III behövde undersökas, vilket utgjorde grunden för föreliggande studie. Syftet var att validera det redan normerade föräldraskattningsformuläret SCDI-III med etablerade språktest för att undersöka om det kan användas för att identifiera barn som ligger i riskzonen för språkstörning. Fyrtioen barn (21 flickor och 20 pojkar) i åldersgruppen 3;0-3;11 med svenska som modersmål, och 41 vårdnadshavare deltog i studien. Barnens grammatiska förmågor undersöktes med valideringsinstrumenten SIT (Språkligt Impressivt Test) och Gramba (Grammatiktest för barn) och deras lexikala förmågor undersöktes med BNT (Boston Naming Test) och PPVT-III (Peabody Picture Vocabulary Test). Testningen utfördes på deras respektive förskolor och vårdnadshavarna fyllde i SCDI-III, varefter resultaten jämfördes.  Medelstarka signifikanta korrelationer konstaterades mellan skattningarna på SCDI:s ordproduktionsdel och barnens resultat på BNT respektive PPVT-III, samt mellan föräldrarnas skattningar på formulärets meningsbyggnadsdel och testresultaten på Gramba. Inga signifikanta eller starka korrelationer för meningskomplexitetsdelen i SCDI-III hittades mot något av de fyra testen. Utöver dessa resultat framkom att flickor presterade signifikant bättre än pojkar på Gramba och de äldsta barnen fick signifikant högre resultat än de yngsta på BNT. Resultaten i föreliggande studie tyder på att olika metoder och perspektiv behövs för bedömning av barns språkförmågor. SCDI-III skulle därför kunna vara ett kompletterade verktyg i form av ett samtalsunderlag mellan kliniskt verksamma logopeder och vårdnadshavare, men kan inte användas som enskilt bedömningsinstrument.
The Swedish Communicative Development Inventory (SCDI-III), a parent report instrument, is a modified form of the third version of the MacArthur-Bates Communicative Development Inventory, and has been developed as a research tool for the investigation of the language ability of children aged 2;6 - 4;0 years. It is of great importance that children who are most at risk of developing a language impairment are identified in time in order to increase the possibility to stimulate their language in favourable developmental phases. Clinicians have expressed a need for a material that can provide an overview of a child’s language ability, prior to carrying out further language assessment. The need of such material has contributed to the need for an investigation of the validity of SCDI-III, which has formed the basis for the present study. The purpose was to validate the already standardized parent estimation form SCDI-III with established language assessments to investigate whether it can be used to identify children who are at risk for language impairment. Forty-one children (21 girls and 20 boys) aged 3;0 - 3;11 years, with Swedish as their mother tongue, and 41 guardians participated in the study. The grammatical abilities of the children were examined using the validation tools SIT (Språkligt Impressivt Test) and Gramba (Grammatiktest för barn) and the lexical abilities were examined using BNT (Boston Naming Test) and PPVT-III (Peabody Picture Vocabulary Test). The testing was performed at their respective daycare center, and the guardians filled in SCDI-III, after which the results were compared.   Moderate significant correlations were found between estimations in SCDI’s word production section and the children’s production on the BNT and the result of the PPVT-III, and between parents’ evaluations in the sentence construction section of the questionnaire and the test results on Gramba. No significant or strong correlations in the sentence complexity section of the SCDI-III were found on any of the four SLP assessments. In addition to these results, girls performed significantly better than boys on Gramba and the oldest children had significantly better results than the youngest on the BNT. The results of the present study suggest a need for different methods and perspectives for the assessment of children’s language abilities. SCDI-III could therefore be a complementary tool in providing a basis for discussion between practicing speech-language pathologists and guardians, but cannot be used as an assessment tool by itself.
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MacDonald, Marcia L. E., Eck Miranda van, Reeni B. Hildebrand, Brian W. C. Wong, Nagat Bissada, Piers Ruddle, Anatol Kontush, et al. "Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis." American Heart Association, 2008. http://hdl.handle.net/2429/9434.

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OBJECTIVE—Absence of stearoyl-CoA desaturase-1 (SCD1) in mice reduces plasma triglycerides and provides protection from obesity and insulin resistance, which would be predicted to be associated with reduced susceptibility to atherosclerosis. The aim of this study was to determine the effect of SCD1 deficiency on atherosclerosis. Methods and RESULTS—Despite an antiatherogenic metabolic profile, SCD1 deficiency increases atherosclerosis in hyperlipidemic low density lipoprotein receptor (LDLR)-deficient mice challenged with a western diet. Lesion area at the aortic root is significantly increased in males and females in two models of SCD1 deficiency. Inflammatory changes are evident in the skin of these mice, including increased intercellular adhesion molecule (ICAM)-1 and ulcerative dermatitis. Increases in ICAM-1 and interleukin-6 are also evident in plasma of SCD1-deficient mice. HDL particles demonstrate changes associated with inflammation, including, decreased plasma apoA-II and apoA-I and paraoxonase-1 and increased plasma serum amyloid A. Lipopolysaccharide-induced inflammatory response and cholesterol efflux are not altered in SCD1-deficient macrophages. In addition, when SCD1 deficiency is limited to bone-marrow derived cells, lesion size is not altered in LDLR-deficient mice. CONCLUSIONS—These studies reinforce the crucial role of chronic inflammation in promoting atherosclerosis, even in the presence of antiatherogenic biochemical and metabolic characteristics. [The original version of this article, along with updated information and services is located on the World Wide Web at: http://atvb.ahajournals.org/cgi/content/full/29/3/341] [UBC users: please click on the UBC eLink icon at the bottom of this record]
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Chung, Ki Yong. "Metabolic and genetic regulation in adipose tissue of Angus and Wagyu steers raised to U.S. and Japanese endpoints." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/3909.

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We hypothesized that carcass and fatty acid composition of Angus and Japanese Black (Wagyu) steers would not differ if the steers were fed to a typical U.S. final weight, but that Wagyu steers fed to a typical Japanese endpoint body weight would have greater quality grades and softer fat than Angus steers. Sixteen Angus and 16 Wagyu 8-month-old, weaned steers were assigned to a corn-based diet for 8 or 16 months (n = 4 per breed type and time) or hay-based diet for 12 or 20 months (n = 4 per breed type and time) in a 2 x 2 x 2 factorial arrangement. USDA yield grade was greater at the Japanese endpoint than at the U.S. endpoint in Angus steers (breed x endpoint, P = 0.03). Intramuscular (i.m.) lipid continued to increase to over 20% in the Wagyu steers (P = 0.05), but attained a plateau (14.7%) by 16 months on feed in the Angus steers. These results confirm that Wagyu cattle must be raised to greater physiological maturity before they differ from Angus cattle in M. longissimus thoracis i.m. lipid concentration. Subcutaneous adipose tissue concentrations of oleic (18:1n-9) was greater in Wagyu steers than in Angus steers (P = 0.05). All monounsaturated fatty acids (MUFA) increased between the U.S. and Japanese endpoint, whereas slip points of lipids in s.c. adipose tissue were 10°C lower in Japanese endpoint steers than in U.S. endpoint steers (P = 0.01). Angus adipose tissue exhibited peak SCD enzyme activity at 16 months (corn-based diet) but activity in Wagyu adipose tissue was greatest at 20 months (hay-based diet) (breed x diet x endpoint, P = 0.08). However, SCD gene expression in Angus adipose tissue was maximal at 12 months (hay diet), whereas Wagyu adipose tissue had peak expression at 16 months (corn diet) (P < 0.03). Trans-10, cis-12 CLA has been reported as a potent inhibitor of adipocyte differentiation. CLA (40 µM) strongly decreased SCD and PPARγ expression in bovine adipocytes, even in the presence of 5 mM arginine. It can be concluded that arginine up-regulates bovine preadipocyte differentiation, and CLA antagonizes this effect.
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Hussain, Ghulam. "Rôle de la stéaroyl-CoA désaturase-1 dans le maintien de l'activité musculaire : étude d'un modèle lésionel pour la compréhension des altérations métaboliques caractéristiques de la sclérose latérale amyotrophique." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00921430.

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Les patients SLA et les souris modèles présentent un dysfonctionnement métabolique qui coïncide avec le changement de concentration de différentes espèces lipidiques. Notre hypothèse est qu'un tel dysfonctionnement métabolique au niveau musculaire conduirait aux premiers changements observés dans la SLA. Nous avons montré que l'expression de la stéaroyl-coenzyme A désaturase 1 (SCD1), une enzyme clé de la synthèse des acides gras mono-insaturés à partir des acides gras saturés, est diminuée dans le muscle avant les premiers symptômes moteurs observés chez les souris modèles de SLA. Dans ce modèle murin, les altérations en acides gras au niveau circulant et hépatique, traduisant les changements de SCD1,apparaissent lors des premiers symptômes de la pathologie. De plus, l'inhibition pharmacologique de l'activité de SCD1 mime le phénotype métabolique des souris modèles de SLA. Notre étude a ainsi montré que la diminution de la SCD1 joue un rôle important pour l'activité neuromusculaire. Elle module les besoins énergétiques, maintien l'activité musculaire par augmentation du métabolisme oxydatif et agit sur l'expression de gènes impliqués dans le développement et le fonctionnement de la jonction neuromusculaire. De plus, l'ablation du gène SCD1 stimule la récupération fonctionnelle musculaire après lésion du nerf. L'inhibition pharmacologique de SCD1 apporte également une protection au muscle. Nous avons pu conclure de cette étude qu'une modification de l'expression de SCD1 ainsi que du profil d'acides gras peut apporter une protection au muscle pour lutter contre la pathologie. En outre, des inhibiteurs de l'activité enzymatique de la SCD1 pourraient être développés comme traitement thérapeutique dans la SLA.
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Bruley, Caroline. "La section Sciences du SCD de Nice - Sophia Antipolis." [S.l.] : [s.n.], 2003. http://www.enssib.fr/bibliotheque/documents/dcb/rsbruley.pdf.

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Books on the topic "Scd6"

1

Robert, Powell. The architecture of Soo Chan. Mulgrave, Vic: Images Publishing Group, 2004.

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National Writing Project (School Curriculum Development Committee), ed. The SCDC National Writing Project. [London]: [School Curriculum Development Committee], 1986.

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Semiconductors, Philips. Power bipolar transistors: Databook SC06. (s.l.): Philips, 1999.

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Aaron, Betsky, and SCDA Architects (Firm), eds. SCDA architects: Selected and current works. Mulgrave, Vic: Images Publishing Group, 2004.

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Committee, School Curriculum Development. The National Curriculum, 5-16: Response from SCDC. London: School Curriculum Development Committee, 1987.

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Project, National Writing, ed. About writing: The SCDC National Writing Project newsletter. (London) ((45 Notting Hill Gate, W11 3JB)): School Curriculum Development Committee, 1985.

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School Examinations and Assessment Council. Types and uses of materials: Sc6. London: SEAC, 1992.

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First Year at School: Policy and Practice (Seminar) (1987 Newcombe House, London). Four-year-olds in school: AnNFER/SCDC Seminar report. (U.K.): National Foundation for Educational Research, 1987.

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National Foundation for Educational Research in England and Wales. and School Curriculum Development Committee., eds. Four-year-olds in school: An NFER/SCDC seminar report. [Windsor?]: National Foundation for Educational Research, 1987.

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Project, National Oracy. SCDC National Oracy Project: Evidence to the English Curriculum working group. [London]: SCDC Publications, 1988.

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Book chapters on the topic "Scd6"

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Leung, Alexander K. C., Cham Pion Kao, Andrew L. Wong, Alexander K. C. Leung, Thomas Kolter, Ute Schepers, Konrad Sandhoff, et al. "SCD." In Encyclopedia of Molecular Mechanisms of Disease, 1895. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7389.

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Hofmann, Erik, Patrick Beck, and Erik Füger. "SCD Guide Preparation." In The Supply Chain Differentiation Guide, 35–45. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31936-5_2.

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Popeijus, Herman E. "SCD (Stearoyl-CoA Desaturase)." In Encyclopedia of Signaling Molecules, 4847–53. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101551.

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Popeijus, Herman E. "SCD (Stearoyl-CoA Desaturase)." In Encyclopedia of Signaling Molecules, 1–7. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101551-1.

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Fernández, José Luis, Stephen Johnston, and Jaime Gosálvez. "Sperm Chromatin Dispersion (SCD) Assay." In A Clinician's Guide to Sperm DNA and Chromatin Damage, 137–52. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-71815-6_8.

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Klipstein, P. C., Y. Benny, Y. Cohen, R. Dobromislin, S. Elkind, R. Fraenkel, S. Gliksman, et al. "Advanced Infrared Photodetectors at SCD." In Springer Proceedings in Physics, 31–35. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-9259-1_8.

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Flint, R. Warren. "Case Study Examples of SCD." In Practice of Sustainable Community Development, 405–19. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5100-6_15.

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Anderson, Claire L., and Deepika S. Darbari. "Current Non-HSCT Treatments for SCD." In Sickle Cell Disease and Hematopoietic Stem Cell Transplantation, 65–86. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62328-3_3.

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Peng, Renming, Yang Mei, and Zhengtong Hao. "A Channel Estimation Method on TD-SCDM Terminal." In 2011 International Conference in Electrics, Communication and Automatic Control Proceedings, 1491–96. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-8849-2_192.

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Taguchi, Kenji, Ryo Kurachi, Kiyoshi Sasaki, Nobuhiko Nakamura, Kazuki Tomonaga, and Shuhei Yamashita. "Threat Analysis Framework for Safety Architectures in SCDL." In Lecture Notes in Computer Science, 341–54. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-54549-9_23.

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Conference papers on the topic "Scd6"

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Jadhav, P., S. Ashokkumar, and N. Nagwekar. "Microbial load reduction using modified Solar Conduction Dryer with composite filters." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7728.

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The present work studies the microbial load reduction in sapota and beet root by three different drying methods i.e. Open Sun Drying (OSD), Solar Conduction Drying (SCD) and a modified SCD with filters (SCDF). Parameters analyzed were water activity, moisture content, drying kinetics, Total Viable Counts, Total Fungal Counts and ash content. It was found that the samples dried in SCDF showed least microbial counts, faster drying times and lower ash content as comparison to OSD. This study shows that SCD and its modification provide a better alternative for low cost drying of fruits and vegetables for quality retention. Keywords: Microbial reduction; SCD Filters; Sapota; Beetroot
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Souza, Milene, Marcio Balthazar, and Mônica Yassuda. "CAN COMPUTERIZED NEUROPSYCHOLOGICAL TESTS BETTER DISCRIMINATE SUBJECTIVE COGNITIVE DECLINE IN ELDERLY?" In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda097.

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Background: Subjects with subjective cognitive decline (SCD) are at higher risk of developing mild cognitive impairment (MCI) and Alzheimer’s dementia (AD). By definition, they perform normally on conventional neuropsychological tests. However, it is unclear whether computerized tests can detect subtle changes in this population. Objective: To compare cognitive performance in conventional and computerized tests of the CANTAB battery in people over 55 years old, divided into three subgroups: Controls, SCD and MCI, according to the NIA-AA 2018 criteria. Methods: We included 64 volunteers: 19 controls, 15 SCD, 30 MCI. Principal Component Analysis (PCA) model was used in both tests and naive bayes classifier were used to distinguish SCD from controls. Results: In conventional tests, variability of 57,17%, differentiating only the MCI. The CANTAB showed a subtle difference in dispersion between SCD and controls, with a variability of 30,12%. Cognitive functions with greater differentiation: episodic visual memory and new learning with variability of 72,65%, visual perception and immediate visual memory 51,95% variability, with similar results between the SCD and MCI groups. Attention and psychomotor speed 23,89%. Sustained attention and psychomotor speed with 71,3%. Adjusted for demographic variables, 52,63% of the SCD were classified as MCI in the computerized test, while the conventional one did not change. Conclusion: Computerized tests seem to be more sensitive in differentiating SCDs from controls, resembling the MCI group.
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Kassa, Debessay Fesehaye, and Klara Nahrstedt. "SCDA." In HPDC'13: The 22nd International Symposium on High-Performance Parallel and Distributed Computing. New York, NY, USA: ACM, 2013. http://dx.doi.org/10.1145/2462902.2462928.

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Kassa, Debessay Fesehaye, and Klara Nahrstedt. "SCDA." In the 22nd international symposium. New York, New York, USA: ACM Press, 2013. http://dx.doi.org/10.1145/2493123.2462928.

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Hecht, David A., Phillip C. Y. Sheu, and Jeffrey J. P. Tsai. "SCDL Applications to Drug Discovery." In 2009 Ninth IEEE International Conference on Bioinformatics and BioEngineering (BIBE). IEEE, 2009. http://dx.doi.org/10.1109/bibe.2009.82.

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Pinfold, Wilfred. "Awards & video---SC06 video." In the 2006 ACM/IEEE conference. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1188455.1188705.

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Crowley, Sandra, Helen Housch, and Heather Madison. "SCDM in a Distributed Environment." In 42nd AIAA Aerospace Sciences Meeting and Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2004. http://dx.doi.org/10.2514/6.2004-1216.

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"Message from the SCDI Workshop Chair." In 2012 16th IEEE International Enterprise Distributed Object Computing Conference Workshops (EDOCW). IEEE, 2012. http://dx.doi.org/10.1109/edocw.2012.43.

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Wang, Shu, and Phillip C. Y. Sheu. "SCDL-NL as a Structured Annotation Language." In 2009 IEEE International Conference on Semantic Computing (ICSC). IEEE, 2009. http://dx.doi.org/10.1109/icsc.2009.52.

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Brum, Igor Vilela, Guilherme Diogo Silva, Diego Sant'Ana Sodre, Felipe Melo Nogueira, Samira Luisa dos Apostolos Pereira, and Luiz Henrique Martins Castro. "Myelopathy in sickle cell disease: a case-oriented review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.563.

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Background: Although neurological complications are well recognized in sickle cell disease (SCD), myelopathy has been rarely described. We present the first case report of longitudinally extensive myelitis (LETM) in SCD and review the differential diagnosis of myelopathy in these patients. Design and setting: case-oriented review. Methods: We report the case of a 29-year-old African-Brazilian man with SCD, who experienced a subacute flaccid paraparesis, with T2 sensory level and urinary retention. CSF analysis showed a lymphocytic pleocytosis and increased protein levels. MRI disclosed a longitudinally extensive spinal cord lesion, with a high T2/STIR signal extending from C2 to T12. Serum anti-aquaporin-4 antibody was negative. We searched Medline/ PubMed, Embase, Scopus, and Google Scholar databases for myelopathy in SCD patients. Results: Spinal cord compression by vertebral fractures, extramedullary hematopoietic tissue, and Salmonella epidural abscess have been reported in SCD. We found only three case reports of spinal cord infarction, which is unexpectedly infrequent compared to the prevalence of cerebral infarction in SCD. We found only one case report of varicella-zoster myelitis and no previous report of LETM in SCD patients. Conclusion: Specific and time-sensitive causes of myelopathy should be considered in SCD patients. In addition to compression and ischemia, LETM should be considered as a possible mechanism of spinal cord involvement in SCD.
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Reports on the topic "Scd6"

1

Douglas, Melissa. FY22 SCDS L2: Special Materials. Office of Scientific and Technical Information (OSTI), February 2021. http://dx.doi.org/10.2172/1764187.

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Duarte, Javier, Sergo Jindariani, Ben Kreis, Rivera Rivera, Nhan Tran, Jennifer Ngadiuba, Maurizio Pierini, et al. FERMILAB-SLIDES-19-706-SCD-V. Office of Scientific and Technical Information (OSTI), November 2019. http://dx.doi.org/10.2172/1630707.

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Zhou, Ruhua, Jingjing Xu, Jiaochen Luan, Weiyun Wang, Xinzhi Tang, Yanling Huang, Ziwen Su, Lei Yang, and Zejuan Gu. The Predictive Role of C-Reactive Protein on Sudden Death: A meta-analysis of prospective studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2021. http://dx.doi.org/10.37766/inplasy2021.11.0074.

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This study was a diagnostic research, so the content was decomposed according to PIRO : P: Patients diagnosed with sudden death; I: C-reactive protein; R: There is no gold standard for sudden death, and the definition of sudden death varies from literature to literature. The World Health Organization defines sudden death: "Patients who are normally healthy or seemingly healthy die suddenly due to natural diseases in an unexpectedly short period of time." In our study, sudden death is determined by the history, symptoms, physical examination and electrocardiogram results assesed by doctor. If death events were collected from the patients’ medical records, deaths coded using the International Classification of Diseases-9th Revision, codes 410 to 414 for non-SCD and 798.1 for SCD; or the International Classification of Diseases-10th Revision, codes I20 to I25 for non-SCD and I46 for SCD. All deaths registered as sudden deaths were confirmed in interviews with the patient’s physician or family members again. O: sudden death.
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Crawford, R. K. SCD1-general-purpose single-crystal diffractometer-reference instrument WBS 1.7.5. Office of Scientific and Technical Information (OSTI), January 1999. http://dx.doi.org/10.2172/12077.

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Doyle, R. E. Cooling water for SSC experiments: Supplemental Conceptual Design Report (SCDR). Office of Scientific and Technical Information (OSTI), October 1989. http://dx.doi.org/10.2172/5168820.

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ADAMS, DAVID P., LAURENCE E. BROWN, RONALD S. GOEKE, JUAN A. ROMERO, and ANDREW D. SILVA. Evolution of Stress in ScD{sub 2}/Cr Thin Films Fabricated by Evaporation and High Temperature Reaction. Office of Scientific and Technical Information (OSTI), June 2001. http://dx.doi.org/10.2172/783088.

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Zinin, A. Cooperative Agreement Between the ISOC/IETF and ISO/IEC Joint Technical Committee 1/Sub Committee 6 (JTC1/SC6) on IS-IS Routing Protocol Development. RFC Editor, July 2003. http://dx.doi.org/10.17487/rfc3563.

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