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1

Yu, Bowen, Chen Cheng, Yichun Wu, Luqiang Guo, Dandan Kong, Ze Zhang, Yuanyuan Wang, Enlin Zheng, Yingbin Liu, and Yongning He. "Interactions of ferritin with scavenger receptor class A members." Journal of Biological Chemistry 295, no. 46 (September 9, 2020): 15727–41. http://dx.doi.org/10.1074/jbc.ra120.014690.

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Scavenger receptors are a superfamily of membrane-bound receptors that recognize both self and nonself targets. Scavenger receptor class A (SR-A) has five known members (SCARA1 to -5 or SR-A1 to -A5), which are type II transmembrane proteins that form homotrimers on the cell surface. SR-A members recognize various ligands and are involved in multiple biological pathways. Among them, SCARA5 can function as a ferritin receptor; however, the interaction between SCARA5 and ferritin has not been fully characterized. Here, we determine the crystal structures of the C-terminal scavenger receptor cysteine-rich (SRCR) domain of both human and mouse SCARA5 at 1.7 and 2.5 Å resolution, respectively, revealing three Ca2+-binding sites on the surface. Using biochemical assays, we show that the SRCR domain of SCARA5 recognizes ferritin in a Ca2+-dependent manner, and both L- and H-ferritin can be recognized by SCARA5 through the SRCR domain. Furthermore, the potential binding region of SCARA5 on the surface of ferritin is explored by mutagenesis studies. We also examine the interactions of ferritin with other SR-A members and find that SCARA1 (SR-A1, CD204) and MARCO (SR-A2, SCARA2), which are highly expressed on macrophages, also interact with ferritin. By contrast, SCARA3 and SCARA4, the two SR-A members without the SRCR domain, have no detectable binding with ferritin. Overall, these results provide a mechanistic view regarding the interactions between the SR-A members and ferritin that may help to understand the regulation of ferritin homeostasis by scavenger receptors.
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2

Poynter, S. J., A. L. Monjo, and S. J. DeWitte-Orr. "Identification of three class A scavenger receptors from rainbow trout (Oncorhynchus mykiss): SCARA3, SCARA4, and SCARA5." Fish & Shellfish Immunology 76 (May 2018): 121–25. http://dx.doi.org/10.1016/j.fsi.2018.02.029.

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3

Burgess, Adam. "Scared to death. From BSE to global warming: Why scares are costing us the earth." Health, Risk & Society 13, no. 7-8 (October 2011): 711–12. http://dx.doi.org/10.1080/13698570902796681.

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4

He, Jianyu, Huihui Liu, and Changwen Wu. "Identification of SCARA3, SCARA5 and MARCO of class A scavenger receptor-like family in Pseudosciaena crocea." Fish & Shellfish Immunology 41, no. 2 (December 2014): 238–49. http://dx.doi.org/10.1016/j.fsi.2014.07.037.

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5

Sandman, Peter M., and JoAnn M. Valenti. "Scared stiff — or scared into action." Bulletin of the Atomic Scientists 42, no. 1 (January 1986): 12–16. http://dx.doi.org/10.1080/00963402.1986.11459304.

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6

Majeed, Mustafa Usama Abdul. "The Use of MEBO Scar Ointment in the Treatment and Prevention of Post-Operative Wound Scars." International Journal of Pharma Research and Health Sciences 4, no. 3 (2016): 1171–78. http://dx.doi.org/10.21276/ijprhs.2016.03.05.

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7

Sherman, D. J., and K. F. Nordstrom. "Beach scarps." Zeitschrift für Geomorphologie 29, no. 2 (August 7, 1985): 139–52. http://dx.doi.org/10.1127/zfg/29/1985/139.

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8

Mertens, Joan R. "Timeas's Scarab." Metropolitan Museum Journal 24 (January 1989): 53–56. http://dx.doi.org/10.2307/1512867.

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9

Messerli, Douglas. "Scared Cows." boundary 2 14, no. 1/2 (1985): 94. http://dx.doi.org/10.2307/303506.

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10

Newton, Richard. "Scared Sheetless." Journal of Religion and Violence 7, no. 3 (2019): 303–22. http://dx.doi.org/10.5840/jrv202031172.

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The ideology of white supremacy is alive and well in the U.S. This paper argues that those attempting to understand how white supremacy works should delve into recent justifications of anti-black violence rather than simply waiting to spot the white sheets of the Ku Klux Klan. Doing so requires scholars to disabuse themselves of taking for granted the descriptions of what may be characterized as a U.S. Christian-White imaginary and to observe the dynamic, discursive shifts that Jean-Franc̜ois Bayart calls “operational acts of identification.” Drawing on incidents from antebellum slavery to the Black Lives Matter era and beyond, it is argued that white people have long been able to justify anti-black violence by appealing to a biblicist “Negrophobia,” wherein black people are rendered as frightening, even demonic creatures that must be stopped for the good of God’s kingdom. This paper presents a critical history of violence in America that is representative of a devastatingly effective strategy that continues to fortify the functional primacy of whiteness despite popular rejections of racism.
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11

Schollmeyer, Josh. "Scared straight." Bulletin of the Atomic Scientists 61, no. 6 (November 1, 2005): 70. http://dx.doi.org/10.2968/061006019.

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12

Andrews, Nick. "Vaccine scares." Significance 3, no. 4 (November 28, 2006): 158–61. http://dx.doi.org/10.1111/j.1740-9713.2006.00196.x.

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13

Bandy, Steve. "Scared Smart." Academic Emergency Medicine 7, no. 4 (April 2000): 416–17. http://dx.doi.org/10.1111/j.1553-2712.2000.tb02257.x.

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14

Wallis, Laura. "Scared Smokeless." AJN, American Journal of Nursing 113, no. 2 (February 2013): 16. http://dx.doi.org/10.1097/01.naj.0000426673.75245.c6.

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15

Blunkett, David. "Scared straight?" Public Policy Research 15, no. 2 (June 2008): 77–79. http://dx.doi.org/10.1111/j.1744-540x.2008.00515.x.

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16

Rao, R. "Intensive Scares." BMJ 327, no. 7412 (August 23, 2003): 454. http://dx.doi.org/10.1136/bmj.327.7412.454.

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17

Johnson, Dave. "Scared Safe?" Synergist 16, no. 3 (2005): 32. http://dx.doi.org/10.3320/1.2759445.

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18

Hutchinson, Terry, and Kelly Richards. "Scared Straight." Alternative Law Journal 38, no. 4 (December 2013): 229–33. http://dx.doi.org/10.1177/1037969x1303800406.

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19

Vaughan, Adam. "Flying scared." New Scientist 245, no. 3264 (January 2020): 18–19. http://dx.doi.org/10.1016/s0262-4079(20)30066-x.

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20

O'Neill, Geraldine M. "Scared stiff." BioArchitecture 1, no. 1 (January 2011): 29–28. http://dx.doi.org/10.4161/bioa.1.1.14665.

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21

Morgan, Philip D. "Conspiracy Scares." William and Mary Quarterly 59, no. 1 (January 2002): 159. http://dx.doi.org/10.2307/3491645.

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22

Nunhuck, Ayesha. "Shit scared." BMJ 326, Suppl S6 (June 1, 2003): 0306204. http://dx.doi.org/10.1136/sbmj.0306204.

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23

Tucker, Aviezer. "Scarce justice." Politics, Philosophy & Economics 11, no. 1 (March 11, 2011): 76–96. http://dx.doi.org/10.1177/1470594x10387520.

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24

Rose, Joan B. "Small scares." Nature Biotechnology 24, no. 5 (May 2006): 507. http://dx.doi.org/10.1038/nbt0506-507.

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25

Collins, Rachael E., and Diano F. Marrone. "Scared Sick." SAGE Open 5, no. 3 (July 10, 2015): 215824401560251. http://dx.doi.org/10.1177/2158244015602516.

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26

Cooper, Richard A. "Scarce Physicians Encounter Scarce Foundations: A Call For Action." Health Affairs 23, no. 6 (November 2004): 243–49. http://dx.doi.org/10.1377/hlthaff.23.6.243.

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27

Peterson, Phyllis R., and Rodney Ho. "Nervous and Scared." Physician Assistant Clinics 6, no. 3 (July 2021): 479–93. http://dx.doi.org/10.1016/j.cpha.2021.03.002.

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28

Benjamin, Elisabeth. "Scarce Lit Sea." Iowa Review 40, no. 1 (April 2010): 3–11. http://dx.doi.org/10.17077/0021-065x.6830.

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29

Ujhelyi, Michael R. "Scared to Death." Pharmacotherapy 28, no. 11 (November 2008): 1311–14. http://dx.doi.org/10.1592/phco.28.11.1311.

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30

Lucas, Manfred. "A Scarce Commodity." International Society of Hair Restoration Surgery 3, no. 5 (September 1993): 8–9. http://dx.doi.org/10.33589/3.5.0008.

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31

Volčič, Aljoša, and Tudor Zamfirescu. "Ghosts are Scarce." Journal of the London Mathematical Society s2-40, no. 1 (August 1989): 171–78. http://dx.doi.org/10.1112/jlms/s2-40.1.171.

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32

Lamb, H. "Scared Sili [silicones]." Engineering & Technology 14, no. 3 (April 1, 2019): 46–47. http://dx.doi.org/10.1049/et.2019.0307.

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33

Dean, F. "Time is scarce." British Dental Journal 203, no. 5 (September 2007): 227. http://dx.doi.org/10.1038/bdj.2007.796.

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34

Collier, R. "Scared to life." Canadian Medical Association Journal 181, no. 12 (December 7, 2009): 980. http://dx.doi.org/10.1503/cmaj.091858.

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35

Burnside, Irene. "A Scarce Professional." Clinical Nurse Specialist 4, no. 3 (1990): 122–27. http://dx.doi.org/10.1097/00002800-199000430-00004.

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36

Wenner, Melinda. "Scared Off Silicone." Scientific American 297, no. 5 (November 2007): 24–26. http://dx.doi.org/10.1038/scientificamerican1107-24.

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37

Smith, G. "Scared to death?" BMJ 325, no. 7378 (December 21, 2002): 1442–43. http://dx.doi.org/10.1136/bmj.325.7378.1442.

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38

Morris, Andrew L., Leslie L. Roos, Ruth Brazauskas, and Dale Bedard. "Managing Scarce Services." Medical Care 28, no. 9 (September 1990): 784–92. http://dx.doi.org/10.1097/00005650-199009000-00008.

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39

&NA;. "“Scared to Death”." American Journal of Forensic Medicine and Pathology 7, no. 3 (September 1986): 267–68. http://dx.doi.org/10.1097/00000433-198607030-00022.

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40

Adee, Sally. "You are… scared." New Scientist 232, no. 3103 (December 2016): 34. http://dx.doi.org/10.1016/s0262-4079(16)32289-8.

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41

Carney, Sean Alexander. "Scared to death." Lancet Infectious Diseases 8, no. 7 (July 2008): 416. http://dx.doi.org/10.1016/s1473-3099(08)70149-x.

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42

Hulme, Dave. "Scared to death?" New Scientist 218, no. 2922 (June 2013): 31. http://dx.doi.org/10.1016/s0262-4079(13)61557-2.

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43

Scully, Anne. "SCARCE RESOURCES AGAIN." Cambridge Law Journal 62, no. 1 (March 1, 2003): 1–3. http://dx.doi.org/10.1017/s0008197303216214.

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44

Hearn, Les. "Scared to death." New Scientist 214, no. 2862 (April 2012): 31. http://dx.doi.org/10.1016/s0262-4079(12)61093-8.

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45

Zardkoohi, Omeed, and Garner T. Haupert. "Scarce Among Men." American Journal of Medicine 120, no. 2 (February 2007): 136–39. http://dx.doi.org/10.1016/j.amjmed.2006.01.030.

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46

Adams, Bob. "David Robert Scarfe." BMJ 334, no. 7589 (February 15, 2007): 373.5–373. http://dx.doi.org/10.1136/bmj.39114.736019.fa.

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47

Bielinsky, Anja-Katrin. "Scarce but scary." Nature Genetics 39, no. 6 (June 2007): 707–8. http://dx.doi.org/10.1038/ng0607-707.

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48

Aimo, Alberto, Marco Di Paolo, Vincenzo Castiglione, Martina Modena, Andrea Barison, Matteo Benvenuti, Valentina Bugelli, et al. "Scared to Death." JACC: Case Reports 2, no. 15 (December 2020): 2400–2403. http://dx.doi.org/10.1016/j.jaccas.2020.08.010.

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49

Hirschtick, Robert E. "Scared of Worms." JAMA 310, no. 6 (August 14, 2013): 583. http://dx.doi.org/10.1001/jama.2013.167500.

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50

Bonfiglio, Robert A. "Our Scared Seniors." About Campus 19, no. 2 (May 2014): 30–32. http://dx.doi.org/10.1002/abc.21154.

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