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1

Sutherland, I. A., L. Brown, A. S. Graham, G. G. Guillon, D. Hawes, L. Janaway, R. Whiteside, and P. Wood. "Industrial Scale-Up of Countercurrent Chromatography: Predictive Scale-Up." Journal of Chromatographic Science 39, no. 1 (January 1, 2001): 21–28. http://dx.doi.org/10.1093/chromsci/39.1.21.

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2

López, C. M. "ESCALAMIENTO PILOTO DE LA SÍNTESIS DE ZEOLITA NaA A PARTIR DE GELES ALUMINOSILICATOS OBTENIDOS CON MATERIALES INDUSTRIALES VENEZOLANOS NO TRATADOS." Revista Mexicana de Ingeniería Química 17, no. 1 (March 26, 2018): 75–86. http://dx.doi.org/10.24275/uam/izt/dcbi/revmexingquim/2018v17n1/lopezc.

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3

Sadighi, Sepehr, Seyed Reza Seif Mohaddecy, and Mehdi Rashidzadeh. "Modeling, Evaluating and Scaling up a Commercial Multilayer Claus Converter Based on Bench Scale Experiments." Bulletin of Chemical Reaction Engineering & Catalysis 15, no. 2 (May 25, 2020): 465–75. http://dx.doi.org/10.9767/bcrec.15.2.7521.465-475.

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Industrial scale reactors work adiabatically and measuring their performance in an isothermal bench scale reactor is faced with uncertainties. In this research, based on kinetic models previously developed for alumina and titania commercial Claus catalysts, a multilayer bench scale model is constructed, and it is applied to simulate the behavior of an industrial scale Claus converter. It is shown that performing the bench scale isothermal experiments at the temperature of 307 ºC can reliably exhibit the activity of catalytic layers of an industrial Claus converter operating at the weighted average bed temperature (WABT) of 289 ºC. Additionally, an adiabatic model is developed for a target industrial scale Claus reactor, and it is confirmed that this model can accurately predict the temperature, and molar percentages of H2S and CS2. Based on simulation results, 20% of excess amount of Claus catalysts should be loaded to compensate their deactivation during the process cycle life. Copyright © 2020 BCREC Group. All rights reserved
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4

Jackson, A. T. "Some problems of industrial scale-up." Journal of Biological Education 19, no. 1 (March 1985): 48–52. http://dx.doi.org/10.1080/00219266.1985.9654686.

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5

Geipel, Christian, Karl Hauptmeier, Kai Herbrig, Frank Mittmann, Markus Münch, Martin Pötschke, Ludwig Reichel, et al. "Stack Development and Industrial Scale-Up." ECS Transactions 91, no. 1 (July 10, 2019): 123–32. http://dx.doi.org/10.1149/09101.0123ecst.

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6

Sutherland, I. A., A. J. Booth, L. Brown, B. Kemp, H. Kidwell, D. Games, A. S. Graham, et al. "INDUSTRIAL SCALE-UP OF COUNTERCURRENT CHROMATOGRAPHY." Journal of Liquid Chromatography & Related Technologies 24, no. 11-12 (June 30, 2001): 1533–53. http://dx.doi.org/10.1081/jlc-100104362.

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7

Meulenberg, Rogier. "Scale up of industrial enzyme production." New Biotechnology 29 (September 2012): S75. http://dx.doi.org/10.1016/j.nbt.2012.08.209.

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8

Rodriguez, F., M. Ramirez, R. Ruiz, and F. Concha. "Scale-up procedure for industrial cage mills." International Journal of Mineral Processing 97, no. 1-4 (November 2010): 39–43. http://dx.doi.org/10.1016/j.minpro.2010.07.010.

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9

Mascarenhas, João, M. Alexandra Barreiros, and Maria João Brites. "Scale up of microwave annealed FA0.83Cs0.17PbI1.8Br1.2 perovskite towards an industrial scale." Materials Letters: X 5 (March 2020): 100029. http://dx.doi.org/10.1016/j.mlblux.2019.100029.

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10

Hoeks, Frans W. J. M. M., Lotte A. Boon, Fabian Studer, Menno O. Wolff, Freija van der Schot, Peter Vrabél, Rob G. J. M. van der Lans, et al. "Scale-up of stirring as foam disruption (SAFD) to industrial scale." Journal of Industrial Microbiology & Biotechnology 30, no. 2 (February 2003): 118–28. http://dx.doi.org/10.1007/s10295-003-0023-7.

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11

Schmidt, F. R. "Optimization and scale up of industrial fermentation processes." Applied Microbiology and Biotechnology 68, no. 4 (July 7, 2005): 425–35. http://dx.doi.org/10.1007/s00253-005-0003-0.

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12

Pruesse, Ulf, Ulrich Jahnz, Peter Wittlich, and Klaus-Dieter Vorlop. "Scale-up of the jetcutter technology." Chemical Industry 57, no. 12 (2003): 636–40. http://dx.doi.org/10.2298/hemind0312636p.

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The JetCutter is a new, simple and efficient technology for the high throughput encapsulation of various materials inside spherical beads. Monodisperse beads in the particle size range from approximately 0.2 mm up to several millimeters can be prepared at high throughput rates with the JetCutter. The generation of beads is not limited by the fluid viscosity. Thus, also highly viscous fluids even with high loadings of solids, can be processed, which leads to an improved stability of the resulting beads. The JetCutter technology is available in different scales and corresponding throughputs ranging from lab-scale devices (liters per day) up to large scale installations for industrial production purposes (tons per day). The application of the JetCutter for industrial purposes has been well established by geniaLab?, which currently produces more than 40 tons/year of small hydrogel beads.
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13

Toepfl, Stefan. "Pulsed Electric Field food treatment - scale up from lab to industrial scale." Procedia Food Science 1 (2011): 776–79. http://dx.doi.org/10.1016/j.profoo.2011.09.117.

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14

Tuchlenski, A., A. Beckmann, D. Reusch, R. Düssel, U. Weidlich, and R. Janowsky. "Reactive distillation — industrial applications, process design & scale-up." Chemical Engineering Science 56, no. 2 (January 2001): 387–94. http://dx.doi.org/10.1016/s0009-2509(00)00240-2.

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15

MURAKAMI, SEI, RYUSEI NAKANO, and TATSUHIKO MATSUOKA. "Scale-Up of Fermenter. Survey of Industrial Fermenter Specifications." KAGAKU KOGAKU RONBUNSHU 26, no. 4 (2000): 557–62. http://dx.doi.org/10.1252/kakoronbunshu.26.557.

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16

MURAKAMI, Sei, Susumu HARADA, and Shuichi YAMAMOTO. "Scale-Up of Fermenter." Japan Journal of Food Engineering 2, no. 2 (June 15, 2001): 53–61. http://dx.doi.org/10.11301/jsfe2000.2.53.

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17

Ettler, Petr. "Scale-up and scale-down techniques for fermentations of polyene antibiotics." Collection of Czechoslovak Chemical Communications 55, no. 7 (1990): 1730–40. http://dx.doi.org/10.1135/cccc19901730.

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Our philosophy of successful biotechnology transfer to industrial scale covers the comparison of complex sets of microbiological, analytical and bioengineering data from cultivations in various scales and different geometries of mixing with laboratory findings. In particular, the availability of nutrients to producing microorganism should be understood, therefore for quick scaling-up procedure of polyene antibiotics produced by Streptomyces noursei we recommend to use physiological marker as total dehydrogenase activity determination. The utility of scale-down tests for identification of process fluctuation, validation of new substrate batches and simultaneous control of inoculum quality was proved.
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18

Eiden, Ulrich, Rudolf Kaiser, Gunter Schuch, and Dieter Wolf. "Scale-up von Destillationskolonnen." Chemie Ingenieur Technik 67, no. 3 (March 1995): 269–79. http://dx.doi.org/10.1002/cite.330670303.

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19

Zlokarnik, M. "Scale-up und Miniplants." Chemie Ingenieur Technik 75, no. 4 (April 7, 2003): 370–75. http://dx.doi.org/10.1002/cite.200390074.

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20

Medici, Franco. "Recovery of Waste Materials: Technological Research and Industrial Scale-Up." Materials 15, no. 2 (January 17, 2022): 685. http://dx.doi.org/10.3390/ma15020685.

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21

Muhamadali, Howbeer, Yun Xu, David I. Ellis, J. William Allwood, Nicholas J. W. Rattray, Elon Correa, Haitham Alrabiah, Jonathan R. Lloyd, and Royston Goodacre. "Metabolic Profiling of Geobacter sulfurreducens during Industrial Bioprocess Scale-Up." Applied and Environmental Microbiology 81, no. 10 (March 6, 2015): 3288–98. http://dx.doi.org/10.1128/aem.00294-15.

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ABSTRACTDuring the industrial scale-up of bioprocesses it is important to establish that the biological system has not changed significantly when moving from small laboratory-scale shake flasks or culturing bottles to an industrially relevant production level. Therefore, during upscaling of biomass production for a range of metal transformations, including the production of biogenic magnetite nanoparticles byGeobacter sulfurreducens, from 100-ml bench-scale to 5-liter fermentors, we applied Fourier transform infrared (FTIR) spectroscopy as a metabolic fingerprinting approach followed by the analysis of bacterial cell extracts by gas chromatography-mass spectrometry (GC-MS) for metabolic profiling. FTIR results clearly differentiated between the phenotypic changes associated with different growth phases as well as the two culturing conditions. Furthermore, the clustering patterns displayed by multivariate analysis were in agreement with the turbidimetric measurements, which displayed an extended lag phase for cells grown in a 5-liter bioreactor (24 h) compared to those grown in 100-ml serum bottles (6 h). GC-MS analysis of the cell extracts demonstrated an overall accumulation of fumarate during the lag phase under both culturing conditions, coinciding with the detected concentrations of oxaloacetate, pyruvate, nicotinamide, and glycerol-3-phosphate being at their lowest levels compared to other growth phases. These metabolites were overlaid onto a metabolic network ofG. sulfurreducens, and taking into account the levels of these metabolites throughout the fermentation process, the limited availability of oxaloacetate and nicotinamide would seem to be the main metabolic bottleneck resulting from this scale-up process. Additional metabolite-feeding experiments were carried out to validate the above hypothesis. Nicotinamide supplementation (1 mM) did not display any significant effects on the lag phase ofG. sulfurreducenscells grown in the 100-ml serum bottles. However, it significantly improved the growth behavior of cells grown in the 5-liter bioreactor by reducing the lag phase from 24 h to 6 h, while providing higher yield than in the 100-ml serum bottles.
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22

Sutherland, Ian, David Hawes, Svetlana Ignatova, Lee Janaway, and Philip Wood. "Review of Progress Toward the Industrial Scale‐Up of CCC." Journal of Liquid Chromatography & Related Technologies 28, no. 12-13 (July 2005): 1877–91. http://dx.doi.org/10.1081/jlc-200063521.

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23

Schmidt, F. R. "Erratum to: Optimization and scale up of industrial fermentation processes." Applied Microbiology and Biotechnology 68, no. 6 (October 2005): 818–20. http://dx.doi.org/10.1007/s00253-005-0100-0.

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24

Zlokarnik, Marko. "DIMENSIONAL ANALYSIS AND SCALE-UP IN THEORY AND INDUSTRIAL APPLICATION*." Journal of Liposome Research 11, no. 4 (January 2001): 269–307. http://dx.doi.org/10.1081/lpr-100108610.

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25

Zlokarnik, M. "Scale-up from Mini Plants." Chemical Engineering & Technology 27, no. 1 (January 9, 2004): 23–27. http://dx.doi.org/10.1002/ceat.200403158.

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26

Haindl, Susanne, Julia Stark, Jannik Dippel, Sebastian Handt, and Annette Reiche. "Scale‐up of Microfiltration Processes." Chemie Ingenieur Technik 92, no. 6 (February 19, 2020): 746–58. http://dx.doi.org/10.1002/cite.201900025.

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27

Bell, Timothy A. "Challenges in the scale-up of particulate processes—an industrial perspective." Powder Technology 150, no. 2 (February 2005): 60–71. http://dx.doi.org/10.1016/j.powtec.2004.11.023.

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28

Sutherland, Ian A. "Recent progress on the industrial scale-up of counter-current chromatography." Journal of Chromatography A 1151, no. 1-2 (June 2007): 6–13. http://dx.doi.org/10.1016/j.chroma.2007.01.143.

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29

Wang, Guan, Cees Haringa, Wenjun Tang, Henk Noorman, Ju Chu, Yingping Zhuang, and Siliang Zhang. "Coupled metabolic‐hydrodynamic modeling enabling rational scale‐up of industrial bioprocesses." Biotechnology and Bioengineering 117, no. 3 (December 20, 2019): 844–67. http://dx.doi.org/10.1002/bit.27243.

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30

Martin, A. J., S. Mitchell, K. Kunze, K. C. Weston, and J. Pérez-Ramírez. "Visualising compositional heterogeneity during the scale up of multicomponent zeolite bodies." Materials Horizons 4, no. 5 (2017): 857–61. http://dx.doi.org/10.1039/c7mh00088j.

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31

Ronda, A., M. A. Martín-Lara, O. Osegueda, V. Castillo, and G. Blázquez. "Scale-up of a packed bed column for wastewater treatment." Water Science and Technology 77, no. 5 (January 10, 2018): 1386–96. http://dx.doi.org/10.2166/wst.2018.020.

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Abstract After checking the success of the biosorption process to remove heavy metals from wastewater using olive tree pruning as a cheap biosorbent in the laboratory scale, the scale-up is necessary to progress towards industrial applications chance. The aim of this work was the study of the effect of scale-up in the process of biosorption of Pb(II) with olive tree pruning in a packed bed column. Experiments were performed using two different scale-up criteria and results obtained in both scales were compared. Similar parameters were obtained for each pair of equivalent tests, with a slightly advanced of the obtained breakthrough curves in the pilot plant. The experimental results were fitted by the Thomas model and the obtained mean values were KTh = 0.187 mL/min·mg and q0 = 20.59 mg/g for criterion 1 and KTh = 0.217 mL/min·mg and q0 = 20.27 mg/g for criterion 2. Finally, the mathematical model was applied to simulate industrial applications and it was obtained that under optimal operative conditions, a column according to the criterion 1 was able to operate 2.3 h, and a column according to the criterion 2 was able to operate for 3.6 h.
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32

Neubert, Benedikt, Christoph Dohm, Johannes Wortberg, and Marius Janßen. "A process-oriented scale-up/scale-down strategy for industrial blown film processes: Theory and experiments." Journal of Plastic Film & Sheeting 34, no. 3 (November 29, 2017): 324–49. http://dx.doi.org/10.1177/8756087917741926.

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To gain a competitive edge in developing innovative products, new multi-layer film manufacturers need to know whether laboratory-scale blown film line results reliably translate to large-scale production. This, however, is not always the case: Transferring process conditions and getting equal final film properties are not ensured. To address this problem, this paper presents a scale-independent scale-up/scale-down strategy to produce films with consistently similar properties regardless of a plant’s size and design. A second aim is to prove this strategy is applicable by comparing the reference and experimental film mechanical properties. Here, experimental scale-down runs were carried out based on a process-oriented scale-up/scale-down strategy for the blown film process. An industrial production process (>800 kg/h), successfully transferred to a laboratory-scale blown film line, was used as the reference. The introduced process-oriented scale-up/scale-down is based on geometric and dynamic similarity. In this context, blow-up ratio, draw-down ratio and process time have been identified as major scale-up/scale-down variables. Unlike existing scale-up strategies, the process-oriented approach is more flexible in practice. Film mechanical properties taken from the experimental runs were determined by tensile and puncture resistance tests. The compared results confirmed that process-oriented scale-up/scale-down is feasible for the applied material and under the existing plant-specific restrictions. The comparison indicated that most film properties produced on the laboratory-scale plant were comparable to those from the high-capacity blown film line.
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33

van Heugten, Anton J. P., and Herman Vromans. "Scale up of Semisolid Dosage Forms Manufacturing Based on Process Understanding: from Lab to Industrial Scale." AAPS PharmSciTech 19, no. 5 (May 29, 2018): 2330–34. http://dx.doi.org/10.1208/s12249-018-1063-7.

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34

Fu, Chaopeng, and Patrick S. Grant. "Toward Low-Cost Grid Scale Energy Storage: Supercapacitors Based on Up-Cycled Industrial Mill Scale Waste." ACS Sustainable Chemistry & Engineering 3, no. 11 (October 5, 2015): 2831–38. http://dx.doi.org/10.1021/acssuschemeng.5b00757.

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35

Operti, Maria Camilla, Alexander Bernhardt, Silko Grimm, Andrea Engel, Carl Gustav Figdor, and Oya Tagit. "PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up." International Journal of Pharmaceutics 605 (August 2021): 120807. http://dx.doi.org/10.1016/j.ijpharm.2021.120807.

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36

Fiore, S., B. Ruffino, G. Campo, C. Roati, and M. C. Zanetti. "Scale-up evaluation of the anaerobic digestion of food-processing industrial wastes." Renewable Energy 96 (October 2016): 949–59. http://dx.doi.org/10.1016/j.renene.2016.05.049.

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37

Lee, Darryl, Susan Krumdieck, and Sam Davies Talwar. "Scale-up design for industrial development of a PP-MOCVD coating system." Surface and Coatings Technology 230 (September 2013): 39–45. http://dx.doi.org/10.1016/j.surfcoat.2013.06.064.

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38

Yan, Pu-Cha, Guo-Liang Zhu, Jian-Hua Xie, Xiang-Dong Zhang, Qi-Lin Zhou, Yuan-Qiang Li, Wen-He Shen, and Da-Qing Che. "Industrial Scale-Up of Enantioselective Hydrogenation for the Asymmetric Synthesis of Rivastigmine." Organic Process Research & Development 17, no. 2 (January 14, 2013): 307–12. http://dx.doi.org/10.1021/op3003147.

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39

Kodama, Masato, Shouzou Ishizawa, Atsushi Koiwa, Takeo Kanaki, Ken Shibata, and Hirotoshi Motomura. "Scale-up of liquid chromatography for industrial production of parenteral antibiotic E1077." Journal of Chromatography A 707, no. 2 (July 1995): 117–29. http://dx.doi.org/10.1016/0021-9673(95)00140-i.

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40

Eiden, U., R. Kaiser, and G. Schuch. "159. Zum Scale-up von Destillationskolonnen." Chemie Ingenieur Technik 66, no. 9 (September 1994): 1256. http://dx.doi.org/10.1002/cite.3306609160.

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41

Mendorf, Matthias, and David W Agar. "Scale-up of Capillary Extraction Equipment." Chemie Ingenieur Technik 83, no. 7 (June 22, 2011): 1120–24. http://dx.doi.org/10.1002/cite.201100026.

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42

Zahradník, Jindřich, and Milan Rylek. "Design and scale-up of Venturi-tube gas distributors for bubble column reactors." Collection of Czechoslovak Chemical Communications 56, no. 3 (1991): 619–35. http://dx.doi.org/10.1135/cccc19910619.

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General principles of ejector distributors performance are surveyed and demonstrated for two particular cases of Venturi tubes commonly employed for gas dispersion in tower reactors with forced liquid circulation. Design recommendations for the two types of Venturi-tube gas distributors are presented and a general method is outlined for ejector distributors scale-up, based on the decisive effect of energy dissipation rate on the distributors performance. As an illustration, the specific case of Venturi-tube gas distributor design for an industrial reactor for catalytic hydrogenation of rape-seed oil is treated in detail. The procedure included design of a small-scale laboratory reactor for kinetic experiments at real process conditions (scale-down step) and subsequent ejector distributor scale up to dimensions corresponding to the industrial reactor (vessel diameter 1.6 m, effective reactor volume ~ 5 m3). Comparison with other modes of gas dispersion proved superiority of Venturi-tube distributors both on the laboratory- and industrial-scale level, regarding the overall rate of reaction process achieved and/or catalyst load requirements.
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43

Radoiu, Marilena. "Microwave drying process scale-up." Chemical Engineering and Processing - Process Intensification 155 (September 2020): 108088. http://dx.doi.org/10.1016/j.cep.2020.108088.

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44

Kamravamanesh, Donya, Daniel Kiesenhofer, Silvia Fluch, Maximilian Lackner, and Christoph Herwig. "Scale-up challenges and requirement of technology-transfer for cyanobacterial poly (3-hydroxybutyrate) production in industrial scale." International Journal of Biobased Plastics 1, no. 1 (January 2, 2019): 60–71. http://dx.doi.org/10.1080/24759651.2019.1688604.

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45

Piccinno, Fabiano, Roland Hischier, Stefan Seeger, and Claudia Som. "From laboratory to industrial scale: a scale-up framework for chemical processes in life cycle assessment studies." Journal of Cleaner Production 135 (November 2016): 1085–97. http://dx.doi.org/10.1016/j.jclepro.2016.06.164.

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46

Kawanishi, K., K. Yagii, Y. Obata, and S. Kimura. "Scale-up Effect in Internal Mixers." International Polymer Processing 6, no. 4 (December 1991): 279–89. http://dx.doi.org/10.3139/217.910279.

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47

Hickman, Daniel A., Michael T. Holbrook, Samuel Mistretta, and Steven J. Rozeveld. "Successful Scale-up of an Industrial Trickle Bed Hydrogenation Using Laboratory Reactor Data." Industrial & Engineering Chemistry Research 52, no. 44 (April 24, 2013): 15287–92. http://dx.doi.org/10.1021/ie4005354.

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48

Mazzinghy, Douglas Batista, Jens Lichter, Claudio Luiz Schneider, Roberto Galéry, and José Francisco Cabello Russo. "Vertical stirred mill scale-up and simulation: Model validation by industrial samplings results." Minerals Engineering 103-104 (April 2017): 127–33. http://dx.doi.org/10.1016/j.mineng.2016.11.018.

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49

Li, Liang, Ian Kemp, and Mark Palmer. "A DEM-based mechanistic model for scale-up of industrial tablet coating processes." Powder Technology 364 (March 2020): 698–707. http://dx.doi.org/10.1016/j.powtec.2020.01.087.

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50

Kockmann, Norbert, Michael Gottsponer, and Dominique M. Roberge. "Scale-up concept of single-channel microreactors from process development to industrial production." Chemical Engineering Journal 167, no. 2-3 (March 2011): 718–26. http://dx.doi.org/10.1016/j.cej.2010.08.089.

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