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Journal articles on the topic 'Scaffolds 2.5D et 3D'

Author: Grafiati

Published: 20 April 2024

Last updated: 31 July 2025

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1

Luo, En, Jun Cui, Y. Gao, Yun Feng Lin, S. S. Zhu, and J. Hu. "Effect of Pamidronate on Protein Adsorption and Osteoblast Adhesion to Hydroxyapatite Bioceramics Scaffold." Key Engineering Materials 330-332 (February 2007): 885–88. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.885.

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This study is to investigate the effect of PAM on protein adsorption and osteoblastic cells adhesion to HA bioceramics. PAM was immobilized on the surface of HA bioceramics for bone scaffold by chelating. The outermost layer of the specimens was analyzed by XPS and FT-IR. The protein adsorption test was performed using the 10% bovine calf serum absorbed on the specimens in vitro. The osteoblastic cells were inoculated and cultured on the scaffolds. SEM, MTT test and ALP activity test evaluated the cell attachment, proliferation and activity on the scaffolds. Characteristic peaks in XPS and FT-

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Jo, Jinhyeon, and Kwang Sup Eom. "Development of a Three-Dimensional Porous Scaffold Adopting Lithiophilic Silver for a High-Performance Lithium Metal Anode." ECS Meeting Abstracts MA2022-02, no. 64 (2022): 2319. http://dx.doi.org/10.1149/ma2022-02642319mtgabs.

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Lithium metal is the most promising candidate for a high-capacity anode in Li-ion batteries due to the highest theoretical specific capacity (3,860 mAh g-1) and the lowest redox potential (-3.04 V vs S.H.E.) [1]. However, the Li metal anode (LMA) is still challenging to be used practically due to mossy-like dendrite formation, dead Li growth, and infinite volume expansion resulting in safety hazards. Various approaches have been proposed to suppress Li dendrite growth, such as constructing an artificial solid electrolyte layer (ASEI) [2], modifying organic electrolyte [3], preparing lithiophil

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Altrock, Eva, Carla Sens-Albert, Johann-Christoph Jann, et al. "Comparison of Four Different Humanized Hematopoietic Niche Xenotransplantation Methods to Engraft Myelodysplastic Syndromes (MDS)." Blood 134, Supplement_1 (2019): 4227. http://dx.doi.org/10.1182/blood-2019-128075.

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Introduction: Next generation sequencing techniques have identified a large number of MDS associated acquired molecular lesions. However, translation of these possible molecular targets into new therapeutic strategies has been lagging behind. This is also due to a lack of functional experimental models of MDS, in which new hypotheses can be evaluated pre-clinically. Xenograft models in NSG mice have emerged as versatile preclinical platforms for investigation of functional pathomechanisms in MDS ([1] Medyouf et al., 2014, [2] Rouault-Pierre et al., 2017). The limiting factor of these models is

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Speagle 沈, Joshua S. 佳士, Catherine Zucker, Ana Bonaca, et al. "Mapping the Milky Way in 5D with 170 Million Stars." Astrophysical Journal 970, no. 2 (2024): 121. http://dx.doi.org/10.3847/1538-4357/ad2b62.

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Abstract We present Augustus, a catalog of distance, extinction, and stellar parameter estimates for 170 million stars from 14 mag < r < 20 mag and with ∣b∣ > 10° drawing on a combination of optical to near-infrared photometry from Pan-STARRS, 2MASS, UKIDSS, and unWISE along with parallax measurements from Gaia DR2 and 3D dust extinction maps. After applying quality cuts, we find 125 million objects have “high-quality” posteriors with statistical distance uncertainties of ≲10% for objects with well-constrained stellar types. This is a substantial improvement over the distance estimate

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Li, Jialang, Manila Ozhukil Valappil, Erwan Bertin, and Viola Ingrid Birss. "N-Doped Nanoporous Carbon Scaffolds As Catalysts for CO₂ Reduction." ECS Meeting Abstracts MA2022-01, no. 39 (2022): 1782. http://dx.doi.org/10.1149/ma2022-01391782mtgabs.

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The need for clean energy solutions in order to significantly lower our carbon footprint is placing increasing attention on renewable energy, such as wind and solar. However, these technologies suffer from intermittency issues, thus making efficient energy storage and conversion a major requirement. One of the solutions to this problem is electrochemical CO2 reduction (CO2RR), using renewable energy to produce green fuels and chemicals. However, the reduction of CO2 is thermodynamically and kinetically unfavorable. To overcome this, the development of highly efficient and selective electrocata

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Reisner, Erwin. "(Keynote) Reversible CO2 Reduction Electrocatalysis in Solar-Powered Chemistry." ECS Meeting Abstracts MA2023-02, no. 52 (2023): 2517. http://dx.doi.org/10.1149/ma2023-02522517mtgabs.

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Semi-artificial photosynthesis interfaces biological catalysts with synthetic materials such as electrodes or light absorbers to overcome limitations in natural and artificial photosynthesis. The benefit of using biocatalysts in electrocatalytic CO2 reduction is their electrochemical reversibility that enables their operation at very low overpotentials with high selectivity. This presentation will summarise my research group’s progress in integrating the CO2 reducing enzyme formate dehydrogenase into bespoke hierarchical 3D electrode scaffolds and the exploitation in solar-powered catalysis. I

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Roh, Terrence, Ying Chen, Harry Paul, Chengchen Guo, and David Kaplan. "P140 3D BIOENGINEERED TISSUE MODEL OF THE LARGE INTESTINE TO STUDY INFLAMMATORY BOWEL DISEASE." Inflammatory Bowel Diseases 26, Supplement_1 (2020): S34—S35. http://dx.doi.org/10.1093/ibd/zaa010.087.

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Abstract An in vitro model of intestine epithelium with an immune compartment was bioengineered to mimic immunologic responses seen in inflammatory bowel disease [1]. While aspects of intestinal immunity can be modeled in transwells and 2D culture systems, 3D tissue models improve physiological relevance by providing a 3D substrate which enable migration of macrophages towards the epithelium. An intestinal epithelium comprised of non-transformed human colon organoid cells and a subepithelial layer laden with monocyte-derived macrophages was bioengineered to mimic native intestinal mucosa cell

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Bradley, M., L. Baldinger, M. Bhatia, et al. "A pilot study of myeloablative (MA) autologous stem Cell (Auto SCT) followed by reduced intensity (RI) allogeneic transplantation (AlloSCT) in children with relapsed/refractory(R/R) Hodgkin’s disease (HD)." Journal of Clinical Oncology 25, no. 18_suppl (2007): 20007. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.20007.

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20007 Background: Allo SCT may benefit patients with R/R HD by providing a graft vs lymphoma effect. Peggs et al (Lancet 2005) demonstrated durable engraftment and reduced non relapse mortality (NRM) in HD pts post RI Allo SCT. Carella et al (JCO2000) and Gutman et al (BMT2005) demonstrated the success of MA Auto SCT followed by RI AlloSCT in adults with refractory lymphoma. We investigated the feasibility of MA Auto SCT followed by RI Allo SCT in children with R/R HD. Methods: MA conditioning prior to AutoSCT was CTX 1,500 mg/m2 x 4 d, BCNU 100 mg/m2 x 3d, VP-16 800 mg/m2 x 3d. AlloSCT condit

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Setiawan, Deni. "Kajian Pembelajaran BIM di Perguruan Tinggi." Jurnal Civronlit Unbari 7, no. 1 (2022): 43. http://dx.doi.org/10.33087/civronlit.v7i1.96.

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BIM diketahui memiliki banyak manfaat yang dapat mempermudah pekerjaan perencanaan maupun evaluasi dari suatu proyek konstruksi. Manfaat ini dapat memberikan pandangan yang menyeluruh untuk membantu klien maupun pemilik proyek sebelum melakukan tahapan pelaksanaan untuk mengurangi risiko yang akan terjadi. Penggunaan BIM dapat membuat pekerjaan lebih efisien. Salah satu upaya pemerintah untuk mensosialisasikan penggunaan BIM yaitu dengan menerapkan BIM sebagai kompetensi keahlian di tingkat SMK. Hal ini untuk meningkatkan jumlah tenaga kerja yang telah paham mengenai konsep BIM. Zhabrinna, et,

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D'Angelo, Sandra P., Mihaela Druta, Brian Andrew Van Tine, et al. "Safety and efficacy of letetresgene autoleucel (lete-cel; GSK3377794) in advanced myxoid/round cell liposarcoma (MRCLS) following high lymphodepletion (Cohort 2): Interim analysis." Journal of Clinical Oncology 39, no. 15_suppl (2021): 11521. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.11521.

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11521 Background: Cancer testis antigen NY-ESO-1 is expressed in multiple tumor types, including 80‒90% of MRCLS [1,2]. Overall response rates (ORRs) to MRCLS treatment are low (1L, <20%; 2L, <10%) [2]. Lete-cel, an autologous T-cell therapy, targets NY-ESO-1/LAGE-1a+ tumors using a genetically modified, high-affinity T-cell receptor. High-dose lymphodepletion (LD) was linked with better responses in synovial sarcoma [3]; the current study tested this hypothesis in MRCLS. Methods: This open label, pilot study evaluates lete-cel efficacy and safety in advanced MRCLS following low-dose (Co

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Haselager, Marco, Eduard Perelaer, Arnon P. Kater, and Eric Eldering. "Development of a Novel Lymph Node-Based 3D Culture System Promoting Chronic Lymphocytic Leukemia Proliferation and Survival." Blood 136, Supplement 1 (2020): 47–48. http://dx.doi.org/10.1182/blood-2020-141962.

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INTRODUCTION. Primary chronic lymphocytic leukemia (CLL) cells, despite originating from a proliferative disease, rapidly undergo apoptosis in vitro in absence of microenvironmental survival signals1. Although co-culture with stromal cells or the addition of soluble factors can increase and extend CLL survival, no system permits the long-term expansion of CLL cells in vitro2. The difficulties of mimicking a physiologic microenvironment supporting CLL cells hinder in vitro studies of proliferation, drug screens and prevent propagation of rare subclones. For other cancers, various types of 3D cu

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Vaiselbuh, Sarah Rivkah, Houman Khalili, Annette Lee, Peter Gregersen, Jeffrey Michael Lipton, and Johnson M. Liu. "Pediatric Leukemia-Specific miRNA Expression Profiles Induced by the Leukemic Stem Cell Niche." Blood 116, no. 21 (2010): 942. http://dx.doi.org/10.1182/blood.v116.21.942.942.

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Abstract Abstract 942 Background: Emerging evidence suggests that microRNAs (miRNAs) are critical in cancer and adult leukemia by functioning as tumor suppressors and/or oncogenes. Zhang et al identified 32 pediatric acute myeloid leukemia (AML)-specific miRNA patterns by analysis of bone marrow (BM) samples (1). They also established potential miRNAs as biomarkers for predicting CNS-relapse in pediatric acute lymphocytic leukemia (ALL). Altered miRNA expression disrupts normal hematopoiesis and might play a role in niche-induced oncogenesis. Dysfunction of mesenchymal stromal cells induces fo

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Lee, Je-Hwan, Young-Don Joo, Jung-Hee Lee, et al. "A Prospective Randomized Comparison of Idarubicin and High-Dose Daunorubicin in the Induction Chemotherapy for Acute Myeloid Leukemia: An Interim Analysis." Blood 120, no. 21 (2012): 3628. http://dx.doi.org/10.1182/blood.v120.21.3628.3628.

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Abstract Abstract 3628 Introduction: We conducted a randomized trial comparing two different doses of daunorubicin as induction chemotherapy in young adults with acute myeloid leukemia (AML) and showed intensification of induction therapy using a high daily dose of daunorubicin (90 mg/m2/d × 3d) improved both complete remission (CR) rate and survival duration compared to standard daunorubicin dose (45 mg/m2/d × 3d) (Lee JH et al. Blood 2011;118:3832). Our results confirmed the ECOG work (Fernandez HF et al. N Engl J Med 2009;361:1249). Thus, high-dose daunorubicin (90 mg/m2/d) for 3 days shoul

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Quiroga, Josué, Omar Flor, Santiago Solórzano, and José Calahorrano. "Design of a Videolaryngoscope with sensor and pressure alert." Athenea 2, no. 3 (2021): 21–27. http://dx.doi.org/10.47460/athenea.v2i3.13.

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This work presents the design and construction of a laryngoscope model with camera vision that has a vibrating device to alert the medical specialist when the force exerted causes possible damage to the patient's airway during the intubation process. Design and fabrication considerations are described using Cast Material Position (FFD). The design is validated with the use of a high-fidelity simulator, the performance is compared with commercial models and the criteria of specialists are taken into account to improve all the necessary aspects. The model presented a great functional advantage,

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15

Wang, Yuxuan, Shiva Ashoori, Ravi Prakash, and Viola Ingrid Birss. "Optimization of the Morphology of Mesoporous Carbon Scaffolds and Pt Loading Methods for Use in PEMFC Cathodes." ECS Meeting Abstracts MA2025-01, no. 40 (2025): 2123. https://doi.org/10.1149/ma2025-01402123mtgabs.

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Proton exchange membrane fuel cells (PEMFCs) represent a promising technology for reaching net-zero goals and reducing fossil fuel dependence, especially in the automotive sector. However, PEMFCs still face challenges, including sluggish oxygen reduction (ORR) kinetics, durability issues, and high cost. Current PEMFCs utilize 40 wt% Pt/C with typical loadings of 0.3-0.5 mgPt/cm2. Along with the required proton conductor and binder (most commonly Nafion), this contributes significantly to the overall cost of the system. Additionally, the microporous nature of conventional carbon supports and th

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Jung, Hyeonjung, Md Delowar Hossain, and Michal Bajdich. "Impact of Local Structure and Spin on the ORR Performance of Single Atom M-N-C Catalysts." ECS Meeting Abstracts MA2024-02, no. 11 (2024): 1461. https://doi.org/10.1149/ma2024-02111461mtgabs.

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Transition metal single-atom catalysts supported on N-doped graphene (M-N-Cs) offer significant advantages in metal utilization and uniformity of active sites compared to traditional heterogeneous catalysts. They are particularly notable for their superior electrocatalytic Oxygen Reduction Reaction (ORR) performance. Various modifications have been explored, including different metal combinations, different first shell elements (N, C, S, B), and coordination numbers, to enhance electrocatalytic ORR activities. Another emerging focus is the link between their local structure and spin state. The

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Khazaka, Rami, Brendan Marozas, Wonjong Kim, and Michael Givens. "Low Temperature Selective Epitaxy of Group-IV Semiconductors for Nanoelectronics." ECS Meeting Abstracts MA2022-02, no. 32 (2022): 1187. http://dx.doi.org/10.1149/ma2022-02321187mtgabs.

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Continuous improvement of device performance is becoming very challenging as the transistor dimension approaches the physical limits of scalability. In particular, the source/drain (S/D) layer resistivity and contact resistance at the S/D region became major components for further parasitic resistance reduction [1]. Therefore, layers with high active doping concertation is required for future technology nodes. From another side, novel architectures such as 3D-stacked devices constraints the allowed thermal budget for epitaxy processes [2]. In this work, we will review our recent achievements o

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Bansal, Radhika, Andre Corraes, Monica Shaw, et al. "Real World Outcomes with Evolving Management of Cytokine Release Syndrome in CAR-T Therapy." Blood 144, Supplement 1 (2024): 2274. https://doi.org/10.1182/blood-2024-203370.

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Background: Management of cytokine release syndrome (CRS) with chimeric antigen receptor T cell therapy (CAR-T) has evolved in the last decade. First line treatment tocilizumab (toci) was initially given for grade 2 or higher CRS in clinical trials (Toci/CRS≥2). Earlier use of toci in grade 1 CRS was found to be safe without negative impact on clinical response in cohort 4 of ZUMA-1 study for axicabtagene ciloleucel (axi-cel) for B-cell non-Hodgkin lymphoma (NHL; Toci/CRS1). This practice was also adopted for other CAR-T therapies for other disease indications. Subsequently, FDA also updated t

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Lin, Chi Hua Sarah, Beth Shaz, and Rona Singer Weinberg. "Low Dose Umbilical Cord Blood Transplant Results in Skewed Immune Cell Composition Which May Impact Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation." Blood 132, Supplement 1 (2018): 5672. http://dx.doi.org/10.1182/blood-2018-99-111541.

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Abstract Introduction Reconstitution of donor-derived immune system after allogeneic hematopoietic stem cell transplantation (HSCT) is essential for recovery and long-term survival. Despite routine use of human umbilical cord blood (hUCB) as a stem cell source for allogeneic HSCT, much remains unknown regarding the kinetics of immune recovery and correlation with different transplant cell dosages. To study the hUCB repopulating potential, different hUCB CD34+ cell dosages were transplanted into immune deficient NSG mice; hematopoietic cells were then collected and engraftment was analyzed. Met

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Manjum, Marjanul, Saheed Adewale Lateef, Hunter Addison McRay, William Earl Mustain, and Golareh Jalilvand. "Low-Cost Processing of Highly Durable (>1000 cycles) Sulfur Cathodes for Li-S Batteries." ECS Meeting Abstracts MA2022-02, no. 6 (2022): 588. http://dx.doi.org/10.1149/ma2022-026588mtgabs.

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Lithium-sulfur (Li-S) batteries are one of the promising alternatives to modern Lithium-ion Battery (LIB) technology due to their superior specific energy density, which can satisfy the emerging needs of advanced energy storage applications such as electric vehicles and grid-scale energy storage and delivery. However, achieving this high specific energy density is hampered by several challenges inherent to the properties of sulfur and its discharge products. One major issue is related to the insulating nature of S and its fully discharged product (Li2S), which often leads to low utilization of

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Han, Xiaoyu, Qimanguli Saiding, Xiaolu Cai, et al. "Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds." Nano-Micro Letters 15, no. 1 (2023). http://dx.doi.org/10.1007/s40820-023-01187-2.

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AbstractBlood vessels are essential for nutrient and oxygen delivery and waste removal. Scaffold-repairing materials with functional vascular networks are widely used in bone tissue engineering. Additive manufacturing is a manufacturing technology that creates three-dimensional solids by stacking substances layer by layer, mainly including but not limited to 3D printing, but also 4D printing, 5D printing and 6D printing. It can be effectively combined with vascularization to meet the needs of vascularized tissue scaffolds by precisely tuning the mechanical structure and biological properties o

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Nazir, Safdar. "Insulator-to-half metal transition and enhancement of structural distortions in $$\text {Lu}_2 \text {NiIrO}_6$$ double perovskite oxide via hole-doping." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-020-80265-6.

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AbstractUsing density functional theory calculations, we found that recently high-pressure synthesized double perovskite oxide $$\text {Lu}_2 \text {NiIrO}_6$$ Lu 2 NiIrO 6 exhibits ferrimagnetic (FiM) Mott-insulating state having an energy band gap of 0.20 eV which confirms the experimental observations (Feng et al. in Inorg Chem 58:397–404, 2019). Strong antiferromagnetic superexchange interactions between high-energy half-filled $$\text {Ni}^{+2}$$ Ni + 2 -$$e_g^2\uparrow$$ e g 2 ↑ and low-energy partially filled $$\text {Ir}^{+4}\,t_{2g}^3\uparrow t_{2g}^2\downarrow$$ Ir + 4 t 2 g 3 ↑ t 2

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Di Berardino, C., L. Liverani, G. Capacchietti, A. Peserico, A. R. Boccaccini, and B. Barboni. "P-440 Impact of electrospun scaffold topology on the performance of in-vitro Folliculogenesis applied to preantral ovine follicles." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac107.415.

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Abstract Study question How to improve in-vitro Folliculogenesis (ivF) protocols to address the enlarged demand of fertility preservation? Summary answer Tissue engineering-based approach opens new frontiers for ivF improving 3D-technologies addressed to support immature-ovarian-follicle-growth to obtain an increased number of competent oocytes enrolled in Assisted-Reproductive-Technology. What is known already ivF is a promising Assisted-Reproductive-Technology (ART) for preserving and restoring fertility. This technology potentially reproduces the early stages of folliculogenesis and oogenes

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Di Nisio, V., K. Papaikonomou, Z. Xiao, A. Damdimopoulos, P. Damdimopoulou, and A. Salumets. "P-425 Biosilk and ovarioids: recombinant silk as a new tool for establishing a 3D-culture system for human ovarian primary cells." Human Reproduction 38, Supplement_1 (2023). http://dx.doi.org/10.1093/humrep/dead093.775.

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Abstract Study question Can Biosilk be used as scaffold for establishing a 3D-culture system to support attachment and growth of primary cells derived from adult ovarian biopsies? Summary answer The use of recombinant spider silk-based scaffold allowed the formation of 3D-structured ovarioids from both cortex and medulla isolated from 5 different patients. What is known already Fertility in women is adversely affected by several factors, such as age, environmental pollutants and diseases requiring gonadotoxic treatments. Understanding ovarian cell composition and organization may pave the way

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Chen, Ximing, Sinong Liu, Xingkai Zhao, et al. "DNA Nanotechnology‐Endowed Synthetic Immunology^†." Chinese Journal of Chemistry, June 14, 2025. https://doi.org/10.1002/cjoc.70094.

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Comprehensive SummarySynthetic immunology merges synthetic biology and immunology, offering a new paradigm to unravel complex immune mechanisms and address major diseases. Unlike traditional ligand display platforms that face inherent limitations, DNA nanotechnology provides unparalleled programmability and nanoscale precision, enabling the fine‐tuning of key immune parameters like ligand valence state and spatial distribution, as well as receptor‐ligand interaction. This review covers recent advances in DNA nanotechnology for immune modulation, highlighting its role in the programmable design

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Grigoriadis, Ioannis. "CartiGenea®-AC: A Mesenchymal stem cells enriched Autologous Chondrocytes for the Treatment of patients with cartilaginous defects on a New Drug-Cell Combinatory Effect Prediction Algorithm on the Cell Based on Chondro defects Gene Expression and Dose-Response Curve." December 2, 2015. https://doi.org/10.5281/zenodo.34550.

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<strong>CartiGenea®-AC:</strong> Chondrocytes, the predominant cell type within AC, synthesize matrix components. Because AC lacks a major vascular supply, lymphatic drainage, and nervous system innervation, chondrocytes function under avascular, anaerobic conditions, obtaining nutrients by diffusion from synovial fluid. Within AC, metabolic and morphologic profiles of deep-zone chondrocytes are distinct from those populating the superficial tangential zone. The factors responsible for this variation are unknown. Maintaining the chondrocyte phenotype with robust hyaline tissue synthesis<em> in

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