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Academic literature on the topic 'SbyD'

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Published: 1 April 2023

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Journal articles on the topic "SbyD"

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Wright, Paul M., Steven Howell, Jenn Jacobs, and Gabriella McLoughlin. "Implementation and perceived benefits of an after-school soccer program designed to promote social and emotional learning." Journal of Amateur Sport 6, no. 1 (March 13, 2020): 125–45. http://dx.doi.org/10.17161/jas.v6i1.8635.

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Social and emotional learning (SEL) competencies such as self-awareness and relationship skills are predictors of academic success, overall well-being, and avoidance of problematic behaviors. Among school-aged children, research has demonstrated that well-implemented programs teach SEL competencies and life skills (e.g., leadership, responsible decision making) that can transfer to other settings. Similar claims have been made in the field of sport-based youth development (SBYD), however, the SEL framework has not been widely applied in sport programming. Implementation, student learning, and transfer of learning in SBYD programs designed to promote SEL require further exploration. Therefore, the current study examined the implementation and perceived benefits of an after-school soccer program designed to promote SEL. Participants were six coaches and 51 students from three different sites where this program is offered. A multiple case study design was used, integrating data from customized feedback surveys, interviews, systematic observation, and field notes. Results indicated the program reflects many SBYD best practices. Although implementation varied between sites, program culture and core values were consistent. Evidence indicated students learned and applied SEL lessons in the soccer program and that transfer beyond the program was promoted. Participants were most likely to report transfer to the school setting, therefore, future studies should examine this topic more directly. Other implications for research and program implementation are discussed.
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Zakharova, Anna N., Yulia A. Karvounis, and Leonid V. Kapilevich. "Monitoring and Management of Students’ Health, Lifestyle and Physical Activity." Vestnik Tomskogo gosudarstvennogo universiteta, no. 464 (2021): 203–15. http://dx.doi.org/10.17223/15617793/464/23.

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The article presents a critical analysis and assessment of the current state of foreign experience in monitoring and management of health, lifestyle and physical activity of student youth. An important aspect of lifestyle monitoring is the assessment of physical activity. However, monitoring is not an end in itself; its results are used to develop approaches and methods of correction, and to manage the situation. The concept of health management is becoming more and more popular as a set of measures to preserve and restore the health of large social groups. One such methodological approach is Teaching Personal and Social Responsibility (TPSR), a model that uses sports and physical activity to teach adolescents to become personally and socially responsible people. This model focuses on two sets of values: personal responsibility and social responsibility. Effort and self-reliance are goals of personal responsibility, while respecting and helping others is social responsibility. The model has been widely adopted as a program for at-risk youth. The Personal and Social Responsibility Questionnaire (PSRQ) was developed as an indicator for assessing young people’s perceptions of personal and social responsibility. Perceptions of personal and social responsibility are positively correlated with intrinsic motivation. Physical education programs based on health and lifestyle management principles can provide students with positive motivational and emotional experiences that will encourage them to continue participating in physical activity. Physical skills are trasferred into other areas of life activity (SBYD – Sports-Based Youth Development), it is claimed that sports can be used as a tool for psychological, emotional and/or academic development. The research has shown that many sports-based youth development programs contribute to the acquisition of life skills (e.g., leadership, self-control) with the ultimate goal of promoting positive social and academic outcomes for young participants. Researchers call this “life skills transfer” (i.e., the idea that the physical, behavioral and cognitive skills that young people acquire in sports can be used in non-athletic settings to promote healthy development). An important result of the development of the concept of monitoring and managing the health and lifestyle of young people is the formation of a consensus on this issue. According to this consensus, physical activity is seen as an all-encompassing term that consists of many structured and unstructured forms in and outside educational settings, including organized sports, physical education, outdoor recreation, motor programs, breaks, and active modes of transportation. such as cycling and walking.
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Cheetham, A. K., A. M. Chippingdale, S. J. Hibble, and C. J. Woodley. "Chemical characterisation of superconducting phases in the systems Bi[sbnd]Sr[sbnd]Ca[sbnd]Cu[sbnd]O and Tl[sbnd]Ba[sbnd]Ca[sbnd]Cu[sbnd]O; the evidence for cation deficiencies." Phase Transitions 19, no. 4 (December 1989): 223–29. http://dx.doi.org/10.1080/01411598908244513.

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And, F. Frey, and K. Hradil. "Periodic superorder and disorder of decagonal Al[sbnd]Ni[sbnd]Co and Al[sbnd]Co[sbnd]Cu([sbnd]Si) phases." Philosophical Magazine A 74, no. 1 (July 1996): 45–55. http://dx.doi.org/10.1080/01418619608239689.

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Dietderich, D. R., S. Ikeda, Y. Kaieda, K. Togano, and H. Maeda. "Modulated structure of the superconducting phases in Pb-modified Bi[sbnd]Sr[sbnd]Ca[sbnd]Cu[sbnd]O." Phase Transitions 19, no. 4 (December 1989): 161–69. http://dx.doi.org/10.1080/01411598908244508.

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Murase, T., K. Kuroda, K. Suzuki, and H. Saka. "Transmission electron microscopy of dislocations and grain boundaries in Bi[sbnd]Pb[sbnd]Sr[sbnd]Ca[sbnd]Cu[sbnd]O superconductors deformed at 800°C." Philosophical Magazine A 62, no. 6 (December 1990): 583–93. http://dx.doi.org/10.1080/01418619008244793.

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Ribbler, Nancy. "SBFD Update." Perspectives on Fluency and Fluency Disorders 19, no. 3 (November 2009): 106. http://dx.doi.org/10.1044/ffd19.3.106.

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Shao, G., A. P. Miodownik, and P. Tsakiropoulos. "ω-phase formation in V[sbnd]Al and Ti[sbnd]Al[sbnd]V alloys." Philosophical Magazine A 71, no. 6 (June 1995): 1389–408. http://dx.doi.org/10.1080/01418619508244381.

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Mishra, R. S., A. K. Singh, and T. Roy. "Creep of an Al[sbnd]Co[sbnd]Cu quasicrystal." Philosophical Magazine Letters 68, no. 4 (October 1993): 225–30. http://dx.doi.org/10.1080/09500839308242416.

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Higginson, R. L., M. Aindow, and P. S. Bate. "Annealing twins in dilute Al[sbnd]Mn[sbnd]Si alloys." Philosophical Magazine Letters 72, no. 4 (October 1995): 193–98. http://dx.doi.org/10.1080/09500839508242451.

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Dissertations / Theses on the topic "SbyD"

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Löffelmannová, Romana. "Návrh financování revitalizace bytového domu SBD Macocha." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2010. http://www.nusl.cz/ntk/nusl-222794.

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Bemeleit, Derk Julius. "Structural characterization of the DNA repair protein complex SbcC-SbcD of thermotoga maritima." Diss., kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/8072/.

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Fujii, Drielli Gomes Vital. "Aplicação de planejamento baseado na estrutura do receptor na busca de inibidores de cisteíno-proteases parasitárias (cruzaína (T. cruzi) e PCB (Leishmanioses))." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-26072018-160153/.

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Doenças causadas por agentes infecciosos e parasitários são chamadas negligenciadas por não despertarem interesse das indústrias farmacêuticas para o desenvolvimento de novas alternativas terapêuticas. Essas doenças são responsáveis por levar milhões de pessoas à morte todos os anos e afetam principalmente os países pobres e em desenvolvimento. Dentre estas, a doença de Chagas e as leishmanioses, parasitoses causadas por parasitas flagelados pertencentes à família Trypanosomatidae, T. cruzi e Leishmaina sp., respectivamente, se apresentam como um sério problema de saúde pública mundial. Endêmicas em vários países e causando milhões de mortes anualmente, ainda hoje não existem fármacos eficientes e seguros para o tratamento dessas doenças. Este panorama torna eminente a necessidade de pesquisa e desenvolvimento de novos fármacos para essas parasitoses. A busca por agentes quimioterápicos envolve a seleção de vias metabólicas essenciais à sobrevivência dos parasitas. Dentre estas, destacamse cisteíno-proteases presentes nesses tripanossomatídeos, deste modo a cruzaína no T. cruzi, e a CPB2.8 na Leishmania mexicana, se mostram como alvos bioquímicos promissores. A disponibilidade de estruturas cristalográficas da cruzaína e do sequenciamento genômico da CPB2.8, nos permite utilizar estratégias de planejamento de fármacos baseado no receptor (SBDD) na identificação de candidatos a fármacos para essas doenças. Entre as técnicas modernas de SBDD utilizadas, a triagem virtual possibilita identificar promissores candidatos a novos fármacos. Assim neste trabalho, obteve-se por meio da técnica de modelagem comparativa o modelo da enzima CPB2.8 de L. mexicana, visto a indisponibilidade da estrutura cristalográfica no Protein Data Bank (PDB). De modo a refinar o modelo construído realizou-se a simulação por dinâmica molecular de 100ns, apresentando estabilização a partir de 80ns. A simulação por dinâmica molecular foi validada por meio do gráfico de Ramachandran, gráfico de raio de giro, RMSD, gráfico de superfície hidrofóbica. Foram calculados os mapas de interação molecular no programa GRID das seguintes proteínas: cruzaína, CPB2.8, catepsina B e catepsina L, e, posteriormente, foi construído um modelo farmacofórico baseado no sítio ativo das enzimas cruzaína e CPB2.8. O modelo farmacofórico da cruzaína foi validado por curva ROC apresentando valor de AUC 61%. A triagem virtual foi realizada para ambas as proteínas e foram obtidos 369 compostos para a cuzaína e 225 compostos para a CPB2.8. Foi realizado o ancoramento molecular desses compostos obtidos pela triagem virtual a fim de diminuir a quantidade de compostos a serem avaliados experimentalmente.
Neglected diseases are caused by parasites and infectious agents and affect mainly people in poor areas being prevalent in 149 countries and causing 534,000 deaths per year. Among neglected diseases we can highlight Chagas Disease and Leishmaniasis, both have a high rate of morbidity and mortality and both are addressed in this project in the search of new drugs against a NTD. Nowadays, the search for new drugs involves the selection of biological pathways essential for parasite survival, in this class of parasites we can suggest the cysteine proteases, a proteases family present in Trypanosoma cruzi and and Leishmania ssp. In order to obtain a new agent against Neglected Disease in this work was obtained the model of the enzyme CPB2.8 of L. mexicana using the comparative modeling technique, due to the unavailability of the crystallographic structure in the Protein Data Bank (PDB). In order to refine the constructed model was performed the molecular dynamics simulation of 100ns, stabilization was achieved from 80ns. Molecular dynamics simulation was validated using the Ramachandran graph, radius of rotation graph, RMSD, hydrophobic surface area graph. The molecular interaction fields were calculated in the GRID program to cruzain, CPB2.8, cathepsin B and cathepsin L. Based on molecular interaction fields generated pharmacophoric models were constructed using information about the active site of the enzymes cruzain and CPB2.8. The pharmacophoric model of cruzain was validated by ROC curve presenting AUC value of 61%. Virtual screening was performed for both proteins and 369 compounds were obtained for cuzain and 225 compounds for CPB2.8. Docking studies of these compounds was performed in order to decrease the amount of compounds to be evaluated experimentally.
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Mitchell, Sophie Lousie. "A fragment-based drug discovery approach for the development of selective inhibitors of protein kinase CK2." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278650.

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Over the last twenty years, fragment-based drug discovery (FBDD) has emerged as a highly successful way to provide lead compounds for subsequent optimisation into drug candidates. Initial hits usually exhibit lower potency than those identified by more traditional techniques, such as High-Throughput Screening (HTS), but the optimisation phase of FBDD is highly efficient, thus providing superior lead-like compounds. The recent application of FBDD in a variety of protein kinase campaigns has successfully led to the identification of novel binding sites and highly efficient chemical ligands. This demonstrates the utility of the FBDD strategy against well-established kinase targets, where selectivity is otherwise challenging due to significant conservation of the ATP-binding site. Protein kinase CK2 is a ubiquitously expressed and constitutively active regulator of cell growth, proliferation and apoptosis. Elevated levels of CK2 protein and activity have historically been involved in human cancer, including lung, cervical and head and neck cancer types, and its overexpression is associated with worse prognosis. A number of CK2 inhibitors are currently available displaying activity against multiple cancers in vitro and in the clinic, however the majority of these candidates target the ATP-binding site and thus display poor selectivity in kinase panel assays. Here we explore the application of FBDD towards the development of potent and selective inhibitors of the catalytic α-subunit of CK2. This project exploits a novel, conserved binding site, named the αD pocket, for the generation of allosteric inhibitor molecules. Following structure-based optimisation of a potent inhibitor series, and characterisation of a previously unreported binding mode, a fragment linking strategy between the lead αD-site fragment and a low-affinity pseudosubstrate peptide is investigated. This work validates the utility of FBDD towards the discovery of new binding modes, presents a first in class CK2α allosteric inhibitor series and provides the first X-ray crystal structure of protein kinase CK2 in complex with a ligand binding in the substrate-binding channel.
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Ferreira, Glaucio Monteiro. "Busca por inibidores seletivos de Sirtuína 2 de T. cruzi empregando técnicas de planejamento de fármacos baseadona estrutura do receptor." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-08032019-174942/.

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A doença de Chagas, causada pelo parasita Trypanosoma cruzi, acomete entre 6 a 8 milhões de pessoas em todo o mundo. Conhecida como tripanossomíase americana, por ter sido considerada endêmica apenas na América Latina, esta doença, se espalhou para outros continentes devido aos movimentos migratórios se tornando um problema de sáude mundial. Estima-se que 56.000 novos casos e cerca de 12.000 mortes por complicações relacionadas à doença de Chagas anualmente. A quimioterapia disponível para o tratamento é composta apenas por dois fármacos, nifurtimox e benznidazol, no entanto são pouco eficazes na fase crônica da doença. Estes fármacos apresentarem, ainda, efeitos adversos graves e resistência por parte de algumas cepas do parasita. Diante deste panorama, é iminente a necessidade da busca de novos fármacos contra T. cruzi. Para a busca racional de novos quimiterapicos antiparasitários é fundamental a identificação e caracterização de vias metabólicas essenciais à sobrevivência dos parasitas. Assim, a enzima sirtuína 2 - Silent Information Regulator 2 (Sir2), tem importante papel para a infecção por T. cruzi, pois está totalmente envolvida no seu ciclo celular do parasita. Esta é uma enzima NAD+ dependente da classe III histona desacetilases, e se mostra como um interessante alvo bioquímico para o desenvolvimento de antichagásicos. A disponibilidade do sequenciamento genômico da Sir2 nos permite utilizar estratégias de planejamento de fármaco baseado no receptor (SBDD - Structure Based Drug Design) na identificação de candidatos a fármacos para essa doença. Entre as técnicas modernas de SBDD utilizadas, a triagem virtual possibilita identificar e selecionar inibidores enzimáticos potentes e seletivos para o alvo escolhido. Assim, neste trabalho, foi construído por meio da técnica de modelagem comparativa o modelo da enzima Sir2 de T. cruzi. Uma simulação por dinâmica molecular de 200ns, foi realizada para averiguar a estabilidade do modelo obtido. Diante da estabilização do modelo a partir de 100ns, o mesmo foi validado utilizando análise de clusters, RMSD (Root-mean-square Deviation) e análises de frequência de ligações de hidrogênio com o Cofator (NAD+) e os aminoácidos do sítio de catálise foram observadas, estes passos de simulação e validação foram realizados no programa DESMOND. Com o modelo robusto, os campos de interações moleculares (MIFs) foram gerados no programa GRID (Molecular Discovery v2.1) com o intuito de elucidar as regiões favoráveis a interação com a enzima em relação a propriedades físico-químicas da Sir2. A partir dos MIFs favoráveis a Sir2 de T. cruzi foi possível a construção de dois modelos farmacofóricos, o qual se baseou nas interações do Cofator (NAD+) e o sítio de catálise (Nicotinamida). O mesmo foi apliacdo como filtro para Triagem Virtual no programa UNITY da plataforma SYBYL X 2.0, utilizando os bancos de dados ZINC15 e GSK. A triagem resultou na seleção de 8 compostos candidatos a inibidores. Destes foram adquiridos 6 compostos por serem considerados mais promissores devido a complementariedade molecular. Estes foram testados contra a enzima de T. cruzi Sri2. Após o ensaio foi possível avaliar a potência de 4 compostos, sendo o composto CDMS-01 (IC50 = 39,9uM) o mais promissor que será submetido à processos de otimização molecular.
Chagas disease, caused by the parasite Trypanosoma cruzi, affects between 6 and 8 million people worldwide. Also known as American trypanosomiasis, because it is considered endemic only in Latin America, but has spread to other continents due to migratory movements. It is estimated that 56,000 new cases and about 12,000 deaths from complications related to Chagas disease annually. The chemotherapy available for treatment consists of only two drugs, nifurtimox and benznidazole, however these are poorly effective in the chronic phase. These drugs also have serious adverse effects and resistance from strains of the parasite. Faced with this scenario, the need to search for new drugs against T. cruzi is imminent. For the drug planning for new antiparasitic chemotherapics, the identification and characterization of metabolic pathways essential to the survival of parasites is fundamental. Therewith, the sirtuin 2 - Silent Information Regulator 2 (Sir2) enzyme has an important role for T. cruzi infection, since Sir2 in the parasite is totally involved in its cell cycle. This is an NAD+-dependent enzyme of class III histone deacetylases, and it shows an interesting biochemical target for the development of antichagasic. The availability of Sir2 genomic sequencing allows us to use SBDD (Structure Based Drug Design) strategies in identifying drug candidates for this disease. Among the modern techniques of SBDD used, virtual screening makes it possible to identify and select potent and selective enzyme inhibitors for the chosen target. The model of the T. cruzi Sir2 enzyme was constructed using the comparative modeling technique. A molecular dynamics simulation of 200ns was performed to ascertain the stability of the obtained model. Considering the stabilization of the model from 100ns, it was validated using cluster analysis, Root-mean-square Deviation (RMSD) and hydrogen bond frequency analyzes with Cofator (NAD+) and the amino acids of the catalysis site were observed, these simulation and validation steps were performed in the DESMOND program. With the robust model, the molecular interaction fields (MIFs) were generated in the GRID program (Molecular Discovery v2.1) in order to elucidate the regions favorable to the interaction with the enzyme in relation to the physicalchemical properties of Sir2. From the MIFs favorable to Sir2 of T. cruzi it was possible to construct two pharmacophoric models, which was based on the interactions of Cofator (NAD+) and the catalysis site (Nicotinamide). It was also applied as a Virtual screening filter in the UNITY program of the SYBYL X 2.0 platform, using the ZINC15 and GSK databases. Screening resulted in the selection of 8 inhibitor candidate compounds. Six compounds were obtained from the screening, because they were considered more promising, and were tested against T. cruzi Sri2 enzyme. After the assay it was possible to evaluate the potency of 4 compounds, the most promising compound being CDMS-01 (IC50 = 39.9 µM) that will be submitted to molecular optimization processes.
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Costa, J?nior Carlos Antonio Mendes da. "Especifica??es e concep??es de front-end UHF integrado e multipadr?o em tecnologia CMOS 130nm." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br/handle/123456789/19680.

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Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq
O Sistema Brasileiro de Coleta de Dados Ambientais (SBCDA) ? respons?vel pela coleta e transmiss?o de dados meteorol?gicos e ambientais, utilizados por dezenas de institui??es e organiza??es nacionais. O segmento espacial do sistema, composto pelos sat?lites de coleta de dados, ? uma pe?a fundamental para seu funcionamento. Para garantir a continuidade e qualidade desses servi?os, esfor?os s?o voltados para o desenvolvimento de alternativas para a constru??o de novos sat?lites. Visando reduzir o tamanho do atual transponder brasileiro, ? proposto neste trabalho a integra??o de uma interface de r?dio frequ?ncia (do ingl?s FrontEnd) a ser embarcado nos receptores da pr?xima gera??o dos sat?lites SBCDA. O circuito ? concebido respeitando os requisistos do padr?o de coleta de dados internacional, ARGOS, e do SBCDA. Este trabalho foca, portanto, na integra??o de um amplificador de baixo ru?do e dois misturadores na faixa UHF em tecnologia CMOS padr?o. As especifica??es de projeto s?o primeiramente descritas e ent?o as topologias dos circuitos s?o escolhidas. A concep??o dos circuitos ? analisada e os seus par?metros de projeto s?o derivados. Finalmente, seu layout ? concebido e os resultados finais s?o divulgados. O chip ser? fabricado utilizando a tecnologia CMOS padr?o de 130 nm da STmicroelectronics.
The Brazilian Environmental Data Collecting System (SBCDA) collects and broadcasts meteorological and environmental data, to be handled by dozens of institutions and organizations. The system space segment, composed by the data collecting satellites, plays an important role for the system operation. To ensure the continuity and quality of these services, efforts are being made to the development of new satellite architectures. Aiming a reduction of size and power consumption, the design of an integrated circuit containing a receiver front-end is proposed, to be embedded in the next SBCDA satellite generations. The circuit will also operate under the requirements of the international data collecting standard ARGOS. This work focuses on the design of an UHF low noise amplifier and mixers in a CMOS standard technology. The specifi- cations are firstly described and the circuit topologies presented. Then the circuit conception is discussed and the design variables derived. Finally, the layout is designed and the final results are commented. The chip will be fabricated in a 130 nm technology from ST Microelectronics.
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Lopez, Alejandro, and Mario Garcia. "Simulator-Based Design in Practice." Thesis, Linköping University, Department of Management and Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-12164.

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The automotive field is becoming more and more complex and cars are no longer just pure mechanical artifacts. Today much more than 50 % of the functionality of a car is computerized, so, a modern car system is obviously based on mixed technologies which emphasize the need for new approaches to the design process compared to the processes of yesterday. A corresponding technology shift has been experienced in the aerospace industry starting in the late sixties and today aircraft could not fly without its computers and the pilots’ environment has turned to a so called glass cockpit with no iron-made instrumentation left. A very similar change is still going on in the automotive area.

Simulator-Based Design (SBD) refers to design, development and testing new products, systems and applications which include an operator in their operation. Simulator-Based Design has been used for decades in the aviation industry. It has been a common process in this field. SBD may be considered as a more specific application of simulation-based design, where the specific feature is a platform, the simulator itself. The simulator could consist of a generic computer environment in combination with dedicated hardware components, for instance a cockpit. This solution gives us the possibility of including the human operator in the simulation.

The name of the project is Simulator-Based Design in Practice. The purpose of this master thesis is to get a complete practice in how to use a human-in-the-loop simulator as a tool in design activities focusing on the automotive area. This application area may be seen as an example of systems where an operator is included in the operation and thus experience from the car application could be transferred to other areas like aviation or control rooms in the process industry.

During the performance of the project we have gone through the main parts of the SBD process. There are many steps to complete the whole cycle and many of them have iterative loops that connect these steps with the previous one. This process starts with a concept (product/system) and continues with a virtual prototyping stage followed by implementation, test design, human-in-the-loop simulation, data analysis, design synthesis and in the end a product/system decision. An iterative process approach makes the cycle flexible and goal oriented.

We have learnt how to use the simulator and how to perform the whole cycle of SBD. We first started getting familiar with the simulator and the ASim software and then we were trying to reduce the number of computers in the simulator and changing the network in order to find good optimization pf the computer power. The second step has been to implement a new application to the simulator. This new application is the rear mirror view and consists of a new LCD monitor and the rear view vision that must be seen in the new monitor. Finally we updated the cockpit to the new language program Action Script 3.0.

The information gathering consisted of the course Human-System interaction in the University, the introduction course to ASim software and the course of Action Script 3.0.

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Aqar, Dhia Y. "Modelling and Optimization of Conventional and Unconventional Batch Reactive Distillation Processes. Investigation of Different Types Batch Reactive Distillation Columns for the Production of a Number of Esters such as Methyl Lactate, Methyl Decanoate, Ethyl Benzoate, and Benzyl Acetate using gPROMS." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17139.

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The synthesis of a number of alkyl esters such as methyl lactate, methyl decanoate, and ethyl benzoate via esterification in a reactive distillation is quite challenging. It is due to the complexity in the thermodynamic behaviour of the chemical species in the reaction mixture in addition to the difficulty of keeping the reactants together in the reaction section. One of the reactants (in these esterification reactions) having the lowest boiling point can separate from the other reactant as the distillation continues. This can result in a significant drop in the reaction conversion in a conventional reactive distillation whether it is a batch or a continuous column. To overcome this challenge, new different types of batch reactive distillation column configurations: (1) integrated conventional (2) semi-batch (3) integrated semi-batch (4) integrated dividing-wall batch distillation columns have been proposed here. Four esterification reaction schemes such as (a) esterification of lactic acid (b) esterification of decanoic acid (c) esterification of benzoic acid (d) esterification of acetic acid are investigated here. A detailed dynamic model based on mass, energy balances, chemical reaction, and rigorous thermodynamic (chemical and physical) properties is considered and incorporated in the optimisation framework within gPROMS (general PROcess Modelling System) software. It is found that for the methyl lactate system, the i-SBD operation outperforms the classical batch operations (CBD or SBD columns) to satisfy the product constraints. While, for the methyl decanoate system, the i-DWCBD operation outperforms all CBD, DWBD and sr-DWBD configurations by achieving the higher reaction conversion and the maximum product purity. For the ethyl benzoate system, the performance of i-CBD column is superior to the CBD process in terms of product quality, and conversion rate of acid. The CBD process is found to be a more attractive in terms of operating time saving, and annual profit improvement compared to the IBD, and MVD processes for the benzyl acetate system.
The Higher Committee for Education Development in Iraq (HCED)
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Martins, João Paulo Machado. "Triagem virtual de inibidores da enzima di-hidrofolato redutase de Schistosoma mansoni (SmDHFR)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-18102017-152832/.

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A esquistossomose é uma das principais causas de morbidade em países Tropicais e Subtropicais, gerando graves consequências socioeconômicas. Atualmente, os fármacos disponíveis para o tratamento da desta doença são praziquantel e oxamniquina, porém relatos de baixa susceptibilidade do parasita a esses medicamentos sugerem a necessidade de novas estratégias terapêuticas para o tratamento da doença. Todavia, existe pouco interesse da indústria farmacêutica no desenvolvimento de fármacos contra doenças tropicais e negligenciadas, entre as quais se encontra a esquistossomose. Devido a estes fatores, o presente trabalho teve por objetivo geral utilizar ferramentas computacionais para identificar inibidores da SmDHFR candidatos a novos fármacos. Avaliou-se as características exclusivas para a proteína de S. mansoni por meio de uma análise das sequências FASTA em comparação com a DHFR de outros organismos. A fim de garantir a ação seletiva dessas moléculas frente a enzima do parasita, os campos moleculares de interação seletivos para SmDHFR foram calculados e empregados na construção do modelo farmacofórico, o qual foi utilizado na triagem virtual de inibidores de SmDHFR. Os estudos computacionais realizados nos permitiram a seleção de 20 moléculas com uma boa complementariedade com o modelo farmacofórico gerado e com potencial para serem inibidores de SmDHFR.
Schistosomiasis is one of morbidity\'s main causes in tropical and subtropical countries, which leads to serious socioeconomic consequences. Praziquantel and oxamniquina are the drugs currently available for treating this disease, but reports points that the parasite has been resistant to both drugs, which suggests the need for new therapeutic strategies for the treatment of this disease. However, there is little interest in the pharmaceutical industry in developing drugs against neglected tropical diseases, including schistosomiasis. Due to these factors, the present work has the general objective to use computational tools to identify SmDHFR inhibitors which could be good candidates for developing new drugs. Evaluation of the exclusive characteristics of the S. mansoni protein were performed by FASTA sequence analyses in comparison to DHFR from other organisms. In order to guarantee the selective action of these molecules against the parasite enzyme, the molecular interaction fields selective for SmDHFR were calculated and used in the construction of the pharmacophoric model, which was further used in the virtual screening of SmDHFR inhibitors. Computational studies were performed and those led us to 20 molecules with a good complementarity with the pharmacophoric model that was previously generated and with potential to be SmDHFR inhibitors.
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Bergström, Frida, and Marika Björkvall. "Simulation based product development and competitiveness : How does a simulation based product development affect a company’s overall future competitiveness?" Thesis, Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119830.

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The gradually increasing competition that occurs in mature markets, pushes the companies to consider new ways of competing. The more mature the market becomes the higher level of competitive fulfillment and edge is needed. E.g. for Scania the dimension high quality was until now considered a competitive advantage, but is currently evolving towards a dimension that is necessary to fulfill to even act within the market. Thus, companies such as Scania have to push their limits everywhere possible across their organization. One way to push the limits of R&D and product development (PD) is, based on this thesis and other work, implementing a simulation based product development (SBPD) process. The aim of this thesis has been, by applying a quality function deployment (QFD) model, to show the influence a SBPD process can have on increased competitiveness. By combining published literature within the field with empirical results mostly gained from interviews, nine components representing a SBPD process could be found. These components were characterized in the following categories: IT-infrastructure, design, model & test, and organizational. Depending on the level of fulfillment of these components the SBPD process is more or less implemented within the company. The two components that are considered the most important for Scania in terms of both increased competitiveness and a possible transition towards a SBPD process are Virtual representa-tion of the product and the process throughout the whole PD process and A model driven/model based approach. The work of this thesis has also shown, in correlations with previous published literature, that a SBPD process can significantly decrease the lead-time and cost of development, and at the same time increase the knowledge about the product and the process. The research has also shown that a SBPD process can considerably improve both the internal and the external collaboration. However attaining such a process where these competitive advantages can be gained affects the whole organization, the way development is performed and also the way resources are used. A fully implemented SBPD process has been shown to positively impact the following competitive dimensions; Frequency of product introductions, Lead-time of development, PD process flexibility, Degree of innovation, Customization of the offer, Collaboration with internal and external partners, Knowledge about products and processes, R&D cost, manufacturing cost, Focus on customers operational economics, Product quality, Product safety and Focus on environmental sustainability of the product & the processes. But, to get a positive impact on all these dimensions the components representing a SBPD process must be implemented and applied. Furthermore, this thesis also provides a framework for other companies to evaluate the impact a SBPD process can have on their competitiveness. The analysis model aims to guide companies that want to adopt a SBPD process. The framework can indicate how a SBPD process would impact the firm's competitive strategy. But also to provide guidance to which components that would be more important to implement in order to reach a competitive SBPD process.
Den gradvis ökande konkurrens som uppstår på mogna marknader driver företagen att finna nya sätt att konkurrera. Ju mer mogen marknaden blir desto högre blir kraven på konkurrens. För Scania har faktorn hög kvalitet tills nu betraktas som en konkurrensfördel, men utveckling sker istället mot att det kommer att vara en faktor som är nödvändig att uppfylla för att ens kunna agera på marknaden. Företag som Scania måste således utvecklas över hela organisationen. Ett sätt att tänja på gränserna för FoU och produktutveckling (PD) är, baserat på detta arbete och annan tidigare forskning, att genomföra en förändring mot en simulering baserad produktutvecklings-process (SBPD). Syftet med detta examensarbete har varit att, genom att tillämpa en quality function deployment (QFD) modell, visa effekten en SBPD-process kan ha på ökad konkurrenskraft. Genom att kombinera tidigare publicerad litteratur inom området med empiriska resultat, mestadels insamlat genom intervjuer, kunde nio komponenter som utgör en SBPD-process finnas. Dessa komponenter karakteriserades i följande kategorier: IT-infrastruktur, design, modellera och testa och organisatorisk. Beroende på graden av uppfyllnad på dessa komponenter blir den SBPD-processen mer eller mindre implementerad inom företaget. De två komponenterna som anses viktigast för Scania i form av både ökad konkurrenskraft och en eventuell övergång till en SBPD-process är Virtuell representation av produkten och processen genom hela PD-processen och Ett modellbaserat/ modelldrivet arbetssätt används. Arbetet har också visat i korrelation med tidigare publicerad litteratur, att en SBPD-process kommer att minska ledtiden och kostnaden för utveckling avsevärt och samtidigt öka kunskapen om produkten och processen. Denna studie har också visat att en SBPD-process kan förbättra både interna och externa samarbeten. Men att uppnå en sådan process där dessa konkurrens-fördelar kan vinnas kommer att påverka hela organisationen, det sätt som utveckling utförs på och också hur resurserna används. En fullt implementerad SBPD-process har visat positivt påverkan följande konkurrens faktorer; frekvens av produktlanseringar, ledtiden för utveckling, PD-processflexibilitet, innovationsgrad, anpassning av erbjudandet, samarbete med interna och externa partners, kunskap om produkter och processer, FoU kostnader, tillverkningskostnad, fokus på kundernas driftsekonomi, produktkvalitet, produktsäkerhet och miljöpåverkan av både produkten och processen. För att få en positiv inverkan på alla dessa faktorer måste alla komponenter som utgör en SBPD-process implementeras och tillämpas. Dessutom så presenteras även ett ramverk för andra företag att utvärdera effekterna en SBPD-process skulle ha på deras konkurrenskraft. Analysmodellen syftar till att vägleda företag som vill övergå till en SBPD-process. Ramverket kan ange hur en SBPD-process skulle kunna påverka företagets konkurrensstrategi men också ge vägledning om vilka komponenter som kan vara viktigare att börja implementera för att nå en konkurrenskraftig SBPD-process.
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Books on the topic "SbyD"

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Widyarto, Erwan. Ngrasani SBY. Sleman, Yogyakarta: Adiwacana, 2007.

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Noeh, Munawar Fuad. SBY & Islam. Depok: eLSAKU, 2004.

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Fomin, M. A. Sbyt narkotikov: Zashchita ot obvinenii︠a︡. Moskva: Izdatelʹstvo "I︠U︡rlitinform", 2013.

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Saidi, Ridwan. Bencana bersama SBY. Jakarta, Indonesia: Indewa, 2009.

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Usamah, Hisyam, ed. SBY, sang demokrat. [Jakarta]: Dharmapena Pub., 2004.

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Artha, Arwan Tuti. Dunia religius SBY. Baciro, Yogyakarta: Best Publisher, 2009.

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Nasution, Adnan Buyung. Nasihat untuk SBY. Jakarta: Penerbit Buku Kompas, 2012.

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Noeh, Munawar Fuad. Ziarah nurani SBY. Depok: Lembaga Studi dan Advokasi Kerukunan Umat Beragama, 2005.

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Basyar, Basril. SBY & ranah Minang. Padang: Yayasan Citra Budaya Indonesia, 2009.

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Artha, Arwan Tuti. Dunia religius SBY. Baciro, Yogyakarta: Best Publisher, 2009.

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Book chapters on the topic "SbyD"

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Gent, Ian P., Warwick Harvey, Tom Kelsey, and Steve Linton. "Generic SBDD Using Computational Group Theory." In Principles and Practice of Constraint Programming – CP 2003, 333–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-540-45193-8_23.

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Pardasani, R. T., and P. Pardasani. "Effective magnetic moment of [Ni(sbpd)2]." In Magnetic Properties of Paramagnetic Compounds, 3819. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23675-4_3469.

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Mao, Ching-Hao, Hsing-Kuo Pao, Christos Faloutsos, and Hahn-Ming Lee. "SBAD: Sequence Based Attack Detection via Sequence Comparison." In Lecture Notes in Computer Science, 78–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19896-0_7.

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Gilliland, Gary L., Jinquan Luo, Omid Vafa, and Juan Carlos Almagro. "Leveraging SBDD in Protein Therapeutic Development: Antibody Engineering." In Methods in Molecular Biology, 321–49. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-520-6_14.

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Kassé, Bassirou, Moussa Diallo, Bamba Gueye, and Halima Elbiaze. "SBSD: Towards a Proactive Sensor-Based Schistosomiasis Detection." In Innovation and Interdisciplinary Solutions for Underserved Areas, 312–21. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-72965-7_29.

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Pardasani, R. T., and P. Pardasani. "Effective magnetic moment of [Cu(sbpd)(Phen)]ClO4." In Magnetic Properties of Paramagnetic Compounds, 4435. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23675-4_4051.

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Pardasani, R. T., and P. Pardasani. "Effective magnetic moment of [Cu(sbpd)(BiPy)]ClO4." In Magnetic Properties of Paramagnetic Compounds, 4436. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23675-4_4052.

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Nishikawa, Koichi, Yuusuke Maeyama, Yusuke Fukuda, Masaaki Shimizu, Masashi Sato, and Hiroaki Iwakuro. "Reverse Biased Electrochemical Etching of SiC-SBD." In Materials Science Forum, 419–22. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-442-1.419.

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Finn, John. "Application of SBDD to the Discovery of New Antibacterial Drugs." In Methods in Molecular Biology, 291–319. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-520-6_13.

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Imaizumi, Masayuki, Yoichiro Tarui, Shin-Ichi Kinouchi, Hiroshi Nakatake, Yukiyasu Nakao, Tomokatsu Watanabe, Keiko Fujihira, Naruhisa Miura, Tetsuya Takami, and Tatsuo Ozeki. "Switching Characteristics of SiC-MOSFET and SBD Power Modules." In Silicon Carbide and Related Materials 2005, 1289–92. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/0-87849-425-1.1289.

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Conference papers on the topic "SbyD"

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DANESE, SILVIO. "Falta ou perda de resposta aos ant-TNFs. Qual o próximo passo." In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/201400000000000004.

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Souza, Heitor. "Fibrogênese nas doenças inflamatórias intestinais." In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/201400000000000002.

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SAAD-HOSSNE, ROGERIO. "A Doença Retocolite Ulcerativa Termina com a Retocolectomia?" In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/201400000000000008.

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Vieira, Andrea. "Uso prático da Calprotectina fecal na Doença Inflamatória Intestinal (DII)." In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/201400000000000003.

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MOREIRA, ANDRÉ. "Pré e Pós operatório nas DII A Visão do Cirurgião." In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/20140000000000007b.

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Damião, Aderson. "Tópicos de interesse para o especialista Combo ou monoterapia: para todos os anti-TNFs?" In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/20140000000000003c.

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MACHADO, MARTA. "O Momento da Realização da C Colonoscopia: Análise Crítica." In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/20140000000000003b.

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Moraes, Antonio. "Anemia nas Doenças Inflamatórias Intestinais." In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/201400000000000001.

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Zeroncio, Marco. "Perspectivas terapêuticas das DII Biológicos." In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/20140000000000005b.

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Teixeira, Fabio. "Desafios terapêuticos das “bolsites” Bolsite na Visão de um Cirurgião." In SBAD 2014. ALEX TEIXEIRA, 2014. http://dx.doi.org/10.19122/20140000000000009b.

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Reports on the topic "SbyD"

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Saari, Alexandra, Michael Proicou, Janette Frigo, Kevin Mccabe, Marvin Gard, Sanna Sevanto, Adam Warniment, and Louis Borges. Small Burst Data (SBD) Satellite Communications. Office of Scientific and Technical Information (OSTI), August 2014. http://dx.doi.org/10.2172/1149967.

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Saari, Alexandra, Janette Frigo, Kevin Mccabe, Marvin Gard, Sanna Sevanto, Adam Warniment, Louis Borges, and Michael Proicou. Small burst data (SBD) satellite communications. Office of Scientific and Technical Information (OSTI), August 2014. http://dx.doi.org/10.2172/1149968.

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O'Hirok, William. SB3D User Manual, Santa Barbara 3D Radiative Transfer Model. Office of Scientific and Technical Information (OSTI), January 1999. http://dx.doi.org/10.2172/761461.

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Pan, Paul Y., Brian D. Boyer, and Chantell L. Murphy. Safeguards by Design (SBD): Safeguards Guidance for Research Reactors and Critical Assemblies. Office of Scientific and Technical Information (OSTI), November 2012. http://dx.doi.org/10.2172/1055240.

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DeMuth, Scott, and C. Scherer. SAFEGUARDS PERFORMANCE MODELING - Development of Advanced Safeguards by Design (SBD) Analyses Techniques for an Electrochemical Reprocessing Facility, and Comparison with past Similar Efforts for Aqueous Reprocessing. Interim status report for FY 2009. Office of Scientific and Technical Information (OSTI), August 2009. http://dx.doi.org/10.2172/1551006.

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