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Academic literature on the topic 'Sbp1'

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Published: 6 September 2023

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Journal articles on the topic "Sbp1"

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Otsuka, Taketo, Charmaine Kirkham, Aimee Brauer, Mary Koszelak-Rosenblum, Michael G. Malkowski, and Timothy F. Murphy. "The Vaccine Candidate Substrate Binding Protein SBP2 Plays a Key Role in Arginine Uptake, Which Is Required for Growth of Moraxella catarrhalis." Infection and Immunity 84, no. 2 (November 23, 2015): 432–38. http://dx.doi.org/10.1128/iai.00799-15.

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Moraxella catarrhalisis an exclusively human pathogen that is an important cause of otitis media in children and lower respiratory tract infections in adults with chronic obstructive pulmonary disease. A vaccine to preventM. catarrhalisinfections would have an enormous global impact in reducing morbidity resulting from these infections. Substrate binding protein 2 (SBP2) of an ABC transporter system has recently been identified as a promising vaccine candidate antigen on the bacterial surface ofM. catarrhalis. In this study, we showed that SBP1, -2, and -3 individually bind different basic amino acids with exquisite specificity. We engineered mutants that each expressed a single SBP from this gene cluster and showed in growth experiments that SBP1, -2, and -3 serve a nutritional function through acquisition of amino acids for the bacterium. SBP2 mediates uptake of arginine, a strict growth requirement ofM. catarrhalis. Adherence and invasion assays demonstrated that SBP1 and SBP3 play a role in invasion of human respiratory epithelial cells, consistent with a nutritional role in intracellular survival in the human respiratory tract. This work demonstrates that the SBPs of an ABC transporter system function in the uptake of basic amino acids to support growth ofM. catarrhalis. The critical role of SBP2 in arginine uptake may contribute to its potential as a vaccine antigen.
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Elhodaky, Mostafa, and Alan Diamond. "Selenium-Binding Protein 1 in Human Health and Disease." International Journal of Molecular Sciences 19, no. 11 (November 2, 2018): 3437. http://dx.doi.org/10.3390/ijms19113437.

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Selenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds selenium. SBP1 may play important roles in several fundamental physiological functions, including protein degradation, intra-Golgi transport, cell differentiation, cellular motility, redox modulation, and the metabolism of sulfur-containing molecules. SBP1 expression is often reduced in many cancer types compared to the corresponding normal tissues and low levels of SBP1 are frequently associated with poor clinical outcome. In this review, the transcriptional regulation of SBP1, the different physiological roles reported for SBP1, as well as the implications of SBP1 function in cancer and other diseases are presented.
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Bhatter, Nupur, Rajan Iyyappan, and Purusharth I. Rajyaguru. "Characterizing mutations in and genetic interactions of RGG-motif translation repressor Sbp1." Wellcome Open Research 3 (August 22, 2018): 102. http://dx.doi.org/10.12688/wellcomeopenres.14709.1.

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Background: Mechanisms of mRNA fate decisions play an important role in determining if a given mRNA will be translated, stored or degraded upon arrival to cytoplasm. Sbp1 is an important RGG-motif containing protein that is implicated in mRNA fate decisions since it can affect mRNA decapping and translation. Sbp1 represses translation by binding eIF4G1 through its RGG-motif and activates decapping when overexpressed. In order to understand the amino acids important for translation repression activity of Sbp1 we performed mutational analysis of Sbp1 combined with assessing its genetic interaction with another RGG-motif protein Scd6. We created two classes of point mutations a) in aromatic residues of the RGG-motif and b) in residues reported to be phosphorylated. Method: Sequence alignment was performed to identify aromatic residues to be mutated based on conservation. Site-directed mutagenesis approach was used to create several point mutations in Sbp1 expressed under galactose-inducible promoter. The mutants were tested for their ability to cause growth defect upon overexpression. The ability of Sbp1 to affect repression activity of other decapping activators was tested using the same growth assay. Results: Mutation of several aromatic residues in the RGG-motif of Sbp1 led to a weak rescue phenotype. However the phospho-mimetic mutants of Sbp1 did not lead to any kind of growth defect rescue. Deletion of another eIF4G1-binding RGG-motif protein Scd6 does not affect ability of Sbp1 to cause growth defect. On the other hand absence of Sbp1 does not affect ability of Dhh1 and Pat1 to repress translation. Conclusion: Based on our growth assay analysis we conclude that mutated aromatic residues contribute marginally to repression activity of Sbp1 whereas phospho-mimetic mutants do not alter ability of Sbp1 to cause growth defect. Interestingly Scd6 does not affect ability of Sbp1 to repress translation, which in turn does not affect Dhh1 and Pat1.
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Bhatter, Nupur, Rajan Iyyappan, Gayatri Mohanan, and Purusharth I. Rajyaguru. "Exploring the role of RRM domains and conserved aromatic residues in RGG motif of eIF4G-binding translation repressor protein Sbp1." Wellcome Open Research 3 (September 17, 2021): 102. http://dx.doi.org/10.12688/wellcomeopenres.14709.3.

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Background: RNA binding proteins play crucial role in determining if a given mRNA will be translated, stored, or degraded. Sbp1 is an RGG-motif containing protein that is implicated in affecting mRNA decapping and translation. Sbp1 represses translation by binding eIF4G1 through its RGG-motif and activates decapping when overexpressed. In this report, we have assessed the genetic interaction of Sbp1 with decapping activators such as Dhh1, Pat1, and Scd6. We have further analyzed the importance of different domains and specific conserved residues of Sbp1 in its ability to cause over-expression mediated growth defect. Method: Sequence alignment was performed to identify conserved aromatic residues to be mutated. Using site-directed mutagenesis several point mutations and domain deletions were created in Sbp1 expressed under a galactose-inducible promoter. The mutants were tested for their ability to cause growth defect upon over-expression. The ability of Sbp1 to affect over-expression mediated growth defect of other decapping activators was tested using growth assay. Live cell imaging was done to study localization of Sbp1 and its RRM-deletion mutants to RNA granules upon glucose starvation. Results: Mutation of several aromatic residues in the RGG-motif and that of the phosphorylation sites in the RRM domain of Sbp1 did not affect the growth defect phenotype. Deletion of another eIF4G1-binding RGG-motif protein Scd6 does not affect the ability of Sbp1 to cause growth defect. Moreover, absence of Sbp1 did not affect the growth defect phenotypes observed upon overexpression of decapping activators Dhh1 and Pat1. Strikingly deletion of both the RRM domains (RRM1 and RRM2) and not the RNP motifs within them compromised the growth defect phenotype. Sbp1 mutant lacking both RRM1 and RRM2 was highly defective in localizing to RNA granules. Conclusion: This study identifies an important role of RRM domains independent of the RNP motif in Sbp1 function.
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Bhatter, Nupur, Rajan Iyyappan, and Purusharth I. Rajyaguru. "Exploring the role of RRM domains and conserved aromatic residues in RGG motif of eIF4G-binding translation repressor protein Sbp1." Wellcome Open Research 3 (February 6, 2020): 102. http://dx.doi.org/10.12688/wellcomeopenres.14709.2.

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Background: Mechanisms of mRNA fate decisions play an important role in determining if a given mRNA will be translated, stored or degraded upon arrival to cytoplasm. Sbp1 is an important RGG-motif containing protein that is implicated in affecting mRNA decapping and translation. Sbp1 represses translation by binding eIF4G1 through its RGG-motif and activates decapping when overexpressed. In this report we have assessed the genetic interaction of Sbp1 with decapping activators such as Dhh1, Pat1 and Scd6. We have further analyzed the importance of different domains and specific conserved residues of Sbp1 in translation repression activity. Method: Sequence alignment was performed to identify conserved aromatic residues to be mutated. Using site-directed mutagenesis several point mutations and domain deletions was created in Sbp1 expressed under a galactose-inducible promoter. The mutants were tested for their ability to cause growth defect upon over-expression. The ability of Sbp1 to affect over expression mediated growth defect of other decapping activators was tested using growth assay. Live cell imaging was done to study localization of Sbp1 and its RRM-deletion mutants to RNA granules upon glucose starvation. Results: Mutation of several aromatic residues in the RGG-motif and that of the phosphorylation sites in the RRM domain of Sbp1 did not affect the growth defect phenotype. Deletion of another eIF4G1-binding RGG-motif protein Scd6 does not affect the ability of Sbp1 to cause growth defect. Moreover, absence of Sbp1 did not affect the growth defect phenotypes observed upon overexpression of decapping activators Dhh1 and Pat1. Strikingly deletion of both the RRM domains (RRM1 and RRM2) and not the RNP motifs within them compromised the growth defect phenotype. Sbp1 mutant lacking both RRM1 and RRM2 was highly defective in localizing to RNA granules. Conclusion: This study identifies an important role of RRM domains independent of RNP motif in Sbp1 repression activity.
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Novoa, Isabel, Mark G. Rush, and Peter D’Eustachio. "Isolated Mammalian and Schizosaccharomyces pombeRan-binding Domains Rescue S. pombe sbp1 (RanBP1) Genomic Mutants." Molecular Biology of the Cell 10, no. 7 (July 1999): 2175–90. http://dx.doi.org/10.1091/mbc.10.7.2175.

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Mammalian Ran-binding protein-1 (RanBP1) and its fission yeast homologue, sbp1p, are cytosolic proteins that interact with the GTP-charged form of Ran GTPase through a conserved Ran-binding domain (RBD). In vitro, this interaction can accelerate the Ran GTPase-activating protein–mediated hydrolysis of GTP on Ran and the turnover of nuclear import and export complexes. To analyze RanBP1 function in vivo, we expressed exogenous RanBP1, sbp1p, and the RBD of each in mammalian cells, in wild-type fission yeast, and in yeast whose endogenous sbp1 gene was disrupted. Mammalian cells and wild-type yeast expressing moderate levels of each protein were viable and displayed normal nuclear protein import.sbp1 − yeast were inviable but could be rescued by all four exogenous proteins. Two RBDs of the mammalian nucleoporin RanBP2 also rescued sbp1 −yeast. In mammalian cells, wild-type yeast, and rescued mutant yeast, exogenous full-length RanBP1 and sbp1p localized predominantly to the cytosol, whereas exogenous RBDs localized predominantly to the cell nucleus. These results suggest that only the RBD of sbp1p is required for its function in fission yeast, and that this function may not require confinement of the RBD to the cytosol. The results also indicate that the polar amino-terminal portion of sbp1p mediates cytosolic localization of the protein in both yeast and mammalian cells.
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Papazzoni, Cesare Andrea, Beatrice Fornaciari, Luca Giusberti, Michela Simonato, and Eliana Fornaciari. "A new definition of the Paleocene Shallow Benthic Zones (SBP) by means of larger foraminiferal biohorizons, and their calibration with calcareous nannofossil biostratigraphy." Micropaleontology 69, no. 4-5 (2023): 363–400. http://dx.doi.org/10.47894/mpal.69.4.02.

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Three key Paleocene deep-sea sections cropping out in northern Italy contain intercalations of calciturbiditic, larger foraminifera-bearing beds derived from shallow water environments. The reconstructed Southern Alps record obtained by splicing the three sections allowed a direct correlation of the shallow benthic SB and calcareous nannofossils CN Zones, leading new data about the Shallow Benthic biozonation for the Danian-Thanetian interval and proposing four new SBP (Shallow Benthic Paleocene) Zones (SBP1-4). Such revision relies on an innovative biostratigraphic approach based on larger foraminiferal biohorizons instead of marker species according to the traditional approach used since the introduction of the SB Zones. Based on our study, the SBP1/SBP2 boundary turns out to be about 2 Ma after the K/Pg crisis, highlighting a quite fast recovery of the complexity among foraminifera.
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Yu-Rice, Yi, Seby L. Edassery, Nicole Urban, Ingegerd Hellstrom, Karl Erik Hellstrom, Youping Deng, Yan Li, and Judith L. Luborsky. "Selenium-Binding Protein 1 (SBP1) autoantibodies in ovarian disorders and ovarian cancer." Reproduction 153, no. 3 (March 2017): 277–84. http://dx.doi.org/10.1530/rep-16-0265.

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Infertility is a risk factor for ovarian cancer (OvCa). The goal was to determine if antibodies to selenium-binding protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and OvCa patients, and thus could be associated with preneoplasia. Anti-SBP1 was measured by immunoassay against recombinant SBP1, in sera from OvCa (n = 41), infertility (n = 92) and control (n = 87) patients. Infertility causes were POF, unexplained, irregular ovulation or endometriosis. The percent of anti-SBP1-positive sera was higher in POF (P = 0.02), irregular ovulation (P = 0.001), unexplained causes (P = 0.02), late (III–IV)-stage OvCa (P = 0.02) but was not significant in endometriosis, benign ovarian tumors/cysts, early stage (I–II) OvCa or uterine cancer compared to healthy controls. Anti-SBP1 was significantly higher in women with serous (P = 0.04) but not non-serous (P = 0.33) OvCa compared to controls. Also, we determined if anti-SBP1 was associated with CA125 or anti-TP53, markers often studied in OvCa. Anti-TP53 and CA125 were measured by established immunoassays. The ability of anti-SBP1 alone to discriminate infertility or OvCa from controls or when combined with anti-TP53 and CA125, to identify OvCa was evaluated by comparing the area under the curve (AUC) in ROC analysis. Anti-SBP1 alone discriminated infertility (AUC = 0.7; P = 0.001) or OvCa (AUC = 0.67; P = 0.03) from controls. The sensitivity and specificity of OvCa identification was increased by combining CA125, anti-TP53 and anti-SBP1 (AUC = 0.96). Therefore, anti-SBP1 occurs in infertile women with POF, ovulatory disturbances or unexplained infertility and in serous OvCa. This suggests an autoimmune process is associated with the development of serous OvCa.
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Bai, Jianan, Junchi Yu, Jintian Wang, Bingyan Xue, Na He, Ye Tian, Lixia Yang, Yipin Wang, Yanyan Wang, and Qiyun Tang. "DNA Methylation of miR-122 Aggravates Oxidative Stress in Colitis Targeting SELENBP1 Partially by p65NF-κB Signaling." Oxidative Medicine and Cellular Longevity 2019 (March 24, 2019): 1–14. http://dx.doi.org/10.1155/2019/5294105.

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Aberrant microRNA (miRNA) expressions contribute to the development and progression of various diseases, including Crohn’s disease (CD). However, the accurate mechanisms of miRNAs in CD are definitely unclear. We employed colonic tissue samples from normal volunteers and CD patients, an acute mice colitis model induced by 2,4,6-trinitro-benzene-sulfonic acid (TNBS), and a cellular oxidative stress model induced by H2O2 in HT-29 cells to determine the effects of oxidative stress on expressions of miR-122, selenium-binding protein 1 (SELENBP1, SBP1), p65 nuclear factor κB (p65NF-κB) signaling, and DNA methylation. We found that SBP1 was mainly located on epithelial cells and was significantly increased in patients with active CD. SBP1 was the target gene of miR-122. miR-122 expression was downregulated while SBP1 expression was upregulated under TNBS-induced colitis or oxidative stress. Pre-miR-122 or siRNA SBP1 (si-SBP1) treatment ameliorated acute TNBS-induced colitis and H2O2-induced oxidative stress. Cotreatment of pre-miR-122 and si-SBP1 enhanced these effects. Besides, pre-miR-122 and si-SBP1 obviously activated the p65NF-κB signaling by phosphorylation of IκBα. Bisulfite sequencing of the CpG islands in the promoter region of miR-122 showed that CpG methylation was significantly increased under oxidative stress. Treating cells with 5′-AZA which was well known as a DNA-demethylating agent significantly increased miR-122 expression. Our results suggest that oxidative stress-induced DNA methylation of miR-122 aggravates colitis targeting SELENBP1 partially by p65NF-κB signaling and may promote the progression of CD.
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Azmi, Ishara, Brian Davies, Christian Dimaano, Johanna Payne, Debra Eckert, Markus Babst, and David J. Katzmann. "Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1." Journal of Cell Biology 172, no. 5 (February 27, 2006): 705–17. http://dx.doi.org/10.1083/jcb.200508166.

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In eukaryotes, the multivesicular body (MVB) sorting pathway plays an essential role in regulating cell surface protein composition, thereby impacting numerous cellular functions. Vps4, an ATPase associated with a variety of cellular activities, is required late in the MVB sorting reaction to dissociate the endosomal sorting complex required for transport (ESCRT), a requisite for proper function of this pathway. However, regulation of Vps4 function is not understood. We characterize Vta1 as a positive regulator of Vps4 both in vivo and in vitro. Vta1 promotes proper assembly of Vps4 and stimulates its ATPase activity through the conserved Vta1/SBP1/LIP5 region present in Vta1 homologues across evolution, including human SBP1 and Arabidopsis thaliana LIP5. These results suggest an evolutionarily conserved mechanism through which the disassembly of the ESCRT proteins, and thereby MVB sorting, is regulated by the Vta1/SBP1/LIP5 proteins.
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Dissertations / Theses on the topic "Sbp1"

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Schild, Florie. "Caractérisation biochimique et implication dans la réponse au stress de la protéine "Selenium-Binding Protein" (SBP1) chez Arabidopsis thaliana." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV063/document.

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La protéine « Selenium Binding Protein » (SBP1), présente chez la plupart des êtres vivants, a un rôle qui n'est pas encore élucidé. Cette protéine possède dans sa structure primaire de nombreux sites potentiels de liaisons aux métaux. Chez Arabidopsis thaliana, la surexpression de SBP1 augmente la tolérance à deux composés toxiques pour la plante, le cadmium (Cd) et le sélénium (Se) qui sont présents dans les sols pollués. Pour mieux comprendre la fonction de SBP1 dans les mécanismes de détoxication, une démarche intégrée combinant deux approches complémentaires, in vitro et in planta, a été menée. La caractérisation biochimique de SBP1 a mis en évidence ses propriétés chélatrices vis-à-vis de différents ligands dont le Cd et le Se. Le Cd se lie à SBP1 avec un ratio molaire ligand/SBP1 de 3 et un KD de 2,2 × 10-7 M via principalement des acides aminés soufrés et potentiellement à moindre échelle des résidus histidines. Le Se, initialement sous forme SeO32-, se lie à SBP1 de façon covalente, avec un ratio molaire ligand/SBP1 de 1, via les cystéines 21 et 22 pour former une liaison de type R-S-Se-S-R. Les analyses in planta de localisation subcellulaire ont montré que SBP1 était à la fois cytosolique et nucléaire. L'utilisation de lignées bioluminescentes a permis d'analyser la zone promotrice du gène SBP1. Le motif cis ‘GAGAC' connu pour être impliqué dans la régulation de certains gènes à une carence en soufre (S) a été identifié comme élément cis majeur de la régulation de l'expression de SBP1 en réponse à différents stress, dont le Cd et le Se. Ce résultat démontre l'existence d'un lien entre la fonction de SBP1 et une demande en S de la cellule. La surexpression de SBP1 in planta perturbe le niveau d'accumulation du Se dans les parties aériennes, mais pas sa spéciation. L'ensemble de ces résultats semble indiquer que SBP1 soit impliquée dans des mécanismes de détoxication via ses propriétés chélatrices et qu'elle joue également un rôle dans le métabolisme du S et du Se
The function of the protein “Selenium binding protein 1” (SBPP1), present in almost all organisms, is not yet well established. This protein has numerous potential metal binding sites. In Arabidopsis thaliana, SBP1 overexpression increases tolerance to two toxic compounds for the plant, cadmium (Cd) and selenium (Se), which are often found as soil pollutants. For a better understanding of SBP1 function and its involvement in detoxification mechanisms, an integrated approach combining in vitro and in planta experiments, has been performed. Biochemical characterization of SBP1 has revealed its chelating properties to different ligands including Cd and Se. Cd is bound to SBP1 with a metal ion to protein molar ratio of 3 and a KD of 2.2 × 10-7 M mainly via sulfur-containing amino acids and potentially histidine residues. Se from SeO32- can covalently bound SBP1 with a ligand to protein molar ratio of 1. This binding occurs via cysteines 21 and 22 and forms a R-S-Se-S-R complex. In planta analyses have shown that SBP1 is cytosolic and nuclear. The use of bioluminescent lines allowed the identification of a GAGAC motif in the SBP1 promoter region. This motif is a sulfur starvation responsive element and a major cis element involved in SBP1 expression in response to stress, including Cd and Se. The result directly links SBP1 function to an enhanced sulfur demand of the cell. SBP1 over expression in plants disturbs Se accumulation in shoots but not its speciation. All together these results strongly suggested that SBP1 could act as a detoxifying protein through its chelating properties and plays a role in S/Se metabolisms
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Waclawovsky, Alessandro Jaquiel. "Caracterização do gene de SBP2 (Sucrose Binding Protein) de soja em plantas transgênicas de tabaco: análise funcional da proteína e atividade do promotor SBP2." Universidade Federal de Viçosa, 2005. http://www.locus.ufv.br/handle/123456789/10043.

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Em plantas, a energia luminosa é transformada em energia química na forma de carboidratos, os quais são alocados entre os diferentes tecidos vegetais através do floema. Durante este processo, a sacarose, principal carboidrato transportado em plantas superiores, é “carregada” e “descarregada” no floema com o auxílio de transportadores localizados na membrana plasmática. A proteína SBP (“sucrose binding protein”) foi inicialmente identificada pela sua capacidade em ligar a sacarose e, pelo menos, dois homólogos da proteína, SBP1 e SBP2, têm sido descritos em soja. Neste trabalho, nós analisamos a função de SBP2 em plantas transgênicas de tabaco expressando o cDNA na orientação antisenso e caracterizamos os cis-elementos presentes no promotor que controlam a expressão espacial do gene SBP. Plantas anti- senso na geração T2 apresentaram crescimento e desenvolvimento reduzidos. Este fenótipo, característico de plantas com inibição do transporte de sacarose a longa distância, foi associado a alterações fisiológicas e metabólicas ocorridas, principalmente, na fase vegetativa do desenvolvimento. As plantas apresentaram reduzida fotossíntese e alteração no particionamento de carboidratos, com preferência para o acúmulo de amido nas folhas em detrimento à síntese de sacarose. Nossos dados suportam a hipótese que SBP provavelmente atua no transporte de sacarose a longa distancia no floema, alterando a expressão ou a atividade de proteínas envolvidas em sistemas alternativos de transporte de carboidratos, já que a manipulação dos níveis de SBP também alterou a atividade da invertase e da sintase da sacarose. Consistente com o papel da proteína no transporte de sacarose, um fragmento de 2 kb do promotor de SBP2 dirigiu a expressão do gene repórter de β- glicuronidase (GUS) para as células do floema de folhas, caules e raízes. A caracterização dos cis-elementos presentes no promotor de SBP2 foi realizada por deleções sucessivas na região 5’ e por deleções internas. A deleção da seqüência de - 2000 a -703 causou o acúmulo de GUS em todos os tecidos de folhas, caule e raízes analisados, indicando a presença de cis-elementos que reprimem a atividade do promotor em tecidos, que não o floema, a jusante da posição -703 pb. Deleções sucessivas até a posição -92 indicaram que a atividade tecido-específica do promotor é coordenada pela interação complexa entre elementos negativos e positivos. De fato, elementos negativos fortes foram identificados na seqüência delimitada pelas posições -495 e -370, os quais foram confirmados por experimentos de ganho de função, e também, entre -243 e -193. Foi identificada também uma região silenciadora do meristema radicular na região entre -136 e -92. Uma seqüência curta de 92pb a partir do códon de iniciação de tradução foi capaz de manter altos níveis de expressão basal em todos os tecidos analisados e, portanto, provavelmente representa um promotor eucariótico mínimo em plantas.
The plants are autotrophic organisms with specialized organs that transform the sun light energy in chemical energy as organic compounds, the carbohydrates, which are transported in part to the other organs by phloem. In plants, sucrose is the major transported form of photoassimilated carbon and its translocation involves loading and unloading of the phloem by membrane specific transporters. A sucrose binding protein, SBP, was initially identified by its capacity to bind sucrose and, at least, two SBP homologues, SBP1 and SBP2, have been described in soybean. Here, we analyzed the SBP2 homologue function in tobacco transgenic plants expressing the cDNA in the antisense orientation and characterized the cis-acting elements involved in spatial regulation of the SBP2 promoter. Typical phenotypes of an inhibition of long distance sucrose translocation were observed in the antisense T2 transgenic lines. In general, the growth and development of the transgenic lines was retarded when compared with control plants. This growth-related phenotype was associated with physiological and metabolic alterations during the early plant development. The photosynthetic rate was decreased and the leaf starch content was higher in antisense lines in comparison with control plants. Our data support the hypothesis that SBP may have a regulatory role in phloem sucrose transport by regulating the expression or activity of alternative carbohydrate uptake systems, since the manipulation of the level of the SBP homologue also altered invertase activity and sucrose synthase activity. Consistent with the involvement of SBP in long-distance sucrose transport, the SBP promoter directed the expression of the β-glucuronidase (GUS) reporter gene with high specificity to phloem of leaves, stems and roots of the transgenic tobacco plants. In order to identify potential cis-regulatory elements controlling the spatial expression of SBP promoter, we performed 5’ and internal deletion promoter analyses in transgenic tobacco. The repression of the SBP2 promoter activity in all other tissues of root, stem and leaf is alleviated by deletion of sequences upstream of -703. This indicates that the phloem-specific expression of SBP2 promoter is contributed by tissue-specific silencers in distal sequences as well as phloem-specific elements within proximal sequences of SBP2 promoter. Further deletions of 5’ flanking sequences indicate that SBP2 promoter activity and tissue-specificity is coordinated by negative and positive combinatorial modules that interact to each other in a complex way. Strong negative elements were found in sequences delimited by positions -495 to -370, which were further confirmed by gain-of-function experiments and also between positions -243 and -193. In addition, a root meristem-specific silencer was identified within the region between -136 and -92. A short sequence, spanning from -92 to the start codon, was able to maintain high level of basal expression and may represent a potential eukaryotic minimal promoter.
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Lundquist, Tomas. "Stability of SBP schemes on overlapping domains." Thesis, Linköpings universitet, Beräkningsvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70413.

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Using fnite difference methods for partial differential equations, this thesis focuses on the problem of connecting overlapping solution domains in the context of a frst order hyperbolic problem. Especially the stability properties of such constructions is studied, and a stable general implementation of the the test problem is proposed. However, no energy estimate could be found, and indeed proven not to exist in the natural norm. Finally, an example is also put forward where the interface conditions derived are, for stability considerations, incompatible with the boundary conditions in a coupled system of hyperbolic equations.
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Papp, Laura V., and n/a. "Multiple Levels of Regulation of Human SECIS Binding Protein 2, SBP2." Griffith University. School of Biomolecular and Biomedical Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070208.145623.

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Selenium is an essential trace mineral of fundamental importance to human health. Its beneficial functions are largely attributed to its presence within a group of proteins named selenoproteins in the form of the amino acid selenocysteine (Sec). Recently, it was revealed that the human selenoproteome consists of 25 selenoproteins, and for many of them their function remains unknown. The most prominent known roles of selenoproteins are to maintain the intracellular redox homeostasis, redox regulation of intracellular signalling and thyroid hormone metabolism. Sec incorporation into selenoproteins employs a unique mechanism that involves decoding of the UGA stop codon. The process requires interplay between distinct, intrinsic features such as the Sec Insertion Sequence (SECIS) element, the tRNASec and multiple protein factors. The work presented in this thesis has focused on characterising the regulation of human SECIS binding protein 2, SBP2, a factor central to this process. Experimental approaches combined with bioinformatics analysis revealed that SBP2 is subjected to alternative splicing. A total of nine alternatively spliced transcripts appear to be expressed in cells, potentially encoding five different protein isoforms. The alternative splicing events are restricted to the 5?-region, which is proposed to be dispensable for Sec incorporation. One of the variants identified, contains a mitochondrial targeting sequence that was capable of targetting SBP2 into the mitochondrial compartment. This isoform also appears to be expressed endogenously within the mitochondria in cells. Previous reports have depicted SBP2 as a ribosomal protein, despite the presence of a putative Nuclear Localisation Signal (NLS). In this study it was found that SBP2 subcellular localisation is not restricted to ribosomes. Intrinsic functional NLS and Nuclear Export Signals (NESs), enable SBP2 to shuttle between the nucleus and the cytoplasm via the CRM1 pathway. In addition, the subcellular localisation of SBP2 appears to play an important role in regulating Sec incorporation into selenoproteins. The subcellular localisation of SBP2 is altered by conditions imposing oxidative stress. Several oxidising agents induce the nuclear accumulation of SBP2, which occurs via oxidation of cysteine residues within a novel redox-sensitive cysteine rich domain (CRD). Cysteine residues were to form disulfide bonds and glutathione-mixed disulfides during oxidising conditions, which are efficiently reversed in vitro by the thioredoxin and glutaredoxin systems, respectively. These modifications negatively regulate selenoprotein synthesis. Cells depleted of SBP2 are more sensitive to oxidative stress than control cells, which correlated with a substantial decrease in selenoprotein synthesis after treatment with oxidising agents. These results provide direct evidence that SBP2 is required for Sec incorporation in vivo and suggest that nuclear sequestration of SBP2 under such conditions may represent a mechanism to regulate the expression of selenoproteins. Collectively, these results suggest that SBP2 is regulated at multiple levels: by alternative splicing, changes in subcellar localisation and redox control.
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Papp, Laura V. "Multiple Levels of Regulation of Human SECIS Binding Protein 2, SBP2." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/367554.

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Selenium is an essential trace mineral of fundamental importance to human health. Its beneficial functions are largely attributed to its presence within a group of proteins named selenoproteins in the form of the amino acid selenocysteine (Sec). Recently, it was revealed that the human selenoproteome consists of 25 selenoproteins, and for many of them their function remains unknown. The most prominent known roles of selenoproteins are to maintain the intracellular redox homeostasis, redox regulation of intracellular signalling and thyroid hormone metabolism. Sec incorporation into selenoproteins employs a unique mechanism that involves decoding of the UGA stop codon. The process requires interplay between distinct, intrinsic features such as the Sec Insertion Sequence (SECIS) element, the tRNASec and multiple protein factors. The work presented in this thesis has focused on characterising the regulation of human SECIS binding protein 2, SBP2, a factor central to this process. Experimental approaches combined with bioinformatics analysis revealed that SBP2 is subjected to alternative splicing. A total of nine alternatively spliced transcripts appear to be expressed in cells, potentially encoding five different protein isoforms. The alternative splicing events are restricted to the 5?-region, which is proposed to be dispensable for Sec incorporation. One of the variants identified, contains a mitochondrial targeting sequence that was capable of targetting SBP2 into the mitochondrial compartment. This isoform also appears to be expressed endogenously within the mitochondria in cells. Previous reports have depicted SBP2 as a ribosomal protein, despite the presence of a putative Nuclear Localisation Signal (NLS). In this study it was found that SBP2 subcellular localisation is not restricted to ribosomes. Intrinsic functional NLS and Nuclear Export Signals (NESs), enable SBP2 to shuttle between the nucleus and the cytoplasm via the CRM1 pathway. In addition, the subcellular localisation of SBP2 appears to play an important role in regulating Sec incorporation into selenoproteins. The subcellular localisation of SBP2 is altered by conditions imposing oxidative stress. Several oxidising agents induce the nuclear accumulation of SBP2, which occurs via oxidation of cysteine residues within a novel redox-sensitive cysteine rich domain (CRD). Cysteine residues were to form disulfide bonds and glutathione-mixed disulfides during oxidising conditions, which are efficiently reversed in vitro by the thioredoxin and glutaredoxin systems, respectively. These modifications negatively regulate selenoprotein synthesis. Cells depleted of SBP2 are more sensitive to oxidative stress than control cells, which correlated with a substantial decrease in selenoprotein synthesis after treatment with oxidising agents. These results provide direct evidence that SBP2 is required for Sec incorporation in vivo and suggest that nuclear sequestration of SBP2 under such conditions may represent a mechanism to regulate the expression of selenoproteins. Collectively, these results suggest that SBP2 is regulated at multiple levels: by alternative splicing, changes in subcellar localisation and redox control.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
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DiPuccio, Andrew A. "The Survivor Benefit Plan (SBP) : assessing retirees' cost share." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA366823.

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Machado, Luiz Henrique Jorge. "Análise experimental do comportamento dinâmico de mancais radiais hidrodinâmicos de geometria fixa." Universidade Federal de Minas Gerais, 2006. http://hdl.handle.net/1843/SBPS-7B4P9W.

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Este trabalho apresenta um estudo experimental da influência de mancais radiais hidrodinâmicos cilíndricos e não cilíndricos sobre o comportamento dinâmico de eixos rotativos. Uma bancada de ensaios de rotores horizontais apoiados em dois mancais radiais hidrodinâmicos, capaz de representar diferentes montagens de rotores, é especialmente fabricada para o desenvolvimento desse estudo. Seis mancais hidrodinâmicos de geometria fixa são selecionados para a avaliação da resposta dinâmica de diferentes configurações de rotores. Dois pares de mancais radiais cilíndricos, fabricados por processos de usinagem convencional e por eletro-erosão, e quatro pares de mancais não cilíndricos mancal elítptico (de dois lóbulos ou limão), mancal de dois lóbulos desalinhados (offset), mancal de três lóbulos e mancal de quatro lóbulos fabricados por meio de usinagem de precisão via eletroerosão, são projetados para o sistema de suporte da bancada de rotores desenvolvida nesse trabalho. A análise comparativa do comportamento dinâmico dos seis mancais é efetuada por meio de ensaios de vibrações realizados em condições de velocidade constante e em aceleração. Espectros de freqüência em velocidade zero, espectros de freqüência em diversas velocidades estacionárias de operação, diagramas cascata (waterfall plots) e diagramas das órbitas de precessão do munhão são obtidos a partir da medição das vibrações em diferentes montagens de rotores horizontais suportados pelos mancais selecionados. Acelerômetros e sensores de proximidade sem contato são utilizados para captar os sinais desejados de vibração sobre os mancais sob diferentes condições de carregamento dinâmico. Além dos espectros de freqüência e das órbitas do munhão, a resposta síncrona ao desbalanceamento de diferentes rotores é determinada para cada tipo de mancal para a faixa de velocidades de rotação de 0 a 10.000 rpm. Uma avaliação preliminar do desgaste por contato dos mancais analisados é efetuada por meio de análise metrológica dimensional antes e após os testes de vibração. Os resultados experimentais obtidos permitem a confecção de diversas curvas da resposta dinâmica dos seis mancais analisados, fornecendo subsídios relevantes para a seleção da configuração de mancal radial de geometria fixa mais apropriada para uma dada máquina rotativa. Pela análise comparativa realizada nesse trabalho, a classificação dos mancais analisados baseada na capacidade de atenuar a resposta síncrona ao desbalanceamento de rotores horizontais é dada por: 1) mancal de 2 lóbulos desalinhados (mancal offset); 2) mancal de 3 lóbulos; 3) mancal elíptico; 4) mancal circular de pequena folga radial; 5) mancal circular de grande folga radial; 6) mancal de 4 lóbulos.
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Verticchio, Norimar de Melo. "Análise comparativa das habilidades e competências necessárias para o engenheiro na visão da indústria, dos discentes e dos docentes." Universidade Federal de Minas Gerais, 2006. http://hdl.handle.net/1843/SBPS-756PGQ.

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Formar um engenheiro contemporâneo, com as habilidades e competências exigidas pelo mercado de trabalho, que está cada vez mais competitivo e onde ocorrem constantes mudanças tecnológicas e organizacionais é o grande desafio dos cursos de engenharia do Brasil e do Mundo. Como fazer isso sem ter uma bússola que possa nortear o trabalho dos docentes e da coordenação do curso? Para encontrar essa bússola é necessário identificar as necessidades do mercado, classificá-las em competências e habilidades, comparando-as com a opinião dos docentes e discentes da instituição de ensino, a fim de verificar se o problema está na meta ou se está na implementação efetiva de metodologias de ensino diferenciadas. O instrumento de pesquisa utilizado foi o questionário de Likert, que foi aplicado nos docentes e discentes do curso de graduação em Engenharia Mecânica da UFMG e em profissionais que atuam na indústria. Constata-se que não há muita divergência entre a indústria e a academia, sendo que a academia considerou a maioria das competências e habilidades mais importantes que a indústria. As habilidades e competências intelectuais foram consideradas como essenciais para o engenheiro. Para obter essas competências na universidade é necessária uma formação profissional e principalmente com metodologias pedagógicas diferentes daquelas fornecidas hoje em dia. Verifica-se que o novo currículo do curso de graduação em Engenharia Mecânica possibilita uma flexibilização na formação do engenheiro. O objetivo está bem definido, logo é necessário então melhorar os caminhos pedagógicos, para então atingir o objetivo, que é formar o engenheiro do século XXI.
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Ribeiro, Jose Luiz Silva. "Fresamento do aço vhsuper nos estados recozido e temperado com metal duro e cermet." Universidade Federal de Minas Gerais, 2007. http://hdl.handle.net/1843/SBPS-7A2J3P.

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The concept of costs reduction in all the industrial processes has been continually developed aiming to make companies more competitive. In the dies and moulds production chain this concern is not different. Usually, dies and moulds require long machining and polishing times, which represent from 60 to 80% of the production cost. This work aims to investigate the influence of the cutting parameters when dry face milling VHSUPER tool steel in both annealed and hardened conditions. Cutting tools based on cermet and cemented carbide coated by TiCN + TiN and TiCN + TiN + Al2O3 were evaluated. Moreover, the influence of tool material cutting speed (vc) and feed rate per tooth (fz) on tool life, wear mechanisms, machined surface roughness, three component milling forces and dimensional and geometric tolerances was assessed. Additionally, the cutting temperature was evaluated for the hardened steel only. In the case of the annealed tool steel, the results indicated that, within the cutting range tested, tool life decreased with an increase in cutting speed and reduction in feed rate. Best results were obtained with the TiCN + TiN + Al2O3 coated carbide. When milling the hardened steel, the elevation of both cutting speed and feed rate resulted in shorter tool lives and the TiCN + TiN coated carbide gave best results. When machining the annealed steel, the principal wear mechanisms observed were abrasive wear, adhesion and coating delamination, whereas for the hardened tool steel, coating delamination in coated carbides and chipping in cermet, were the predominant wear mechanisms. Best surface finish was obtained using lower feed rates, irrespectively of the cutting speed and tool material grade employed. In addition to that, feed rate was the principal parameter affecting milling forces, however, cutting speed was the principal parameter affecting the milling temperature of the hardened tool steel. Finally, tighter dimensional and geometric tolerances were obtained after up milling the hardened tool steel. Keywords: milling, tool steel, coated carbide, cermet, milling forces.
O conceito de redução de custos em processos industriais tem sido continuamente desenvolvido para tornar as empresas cada vez mais competitivas. Na cadeia produtiva de matrizes e moldes esta preocupação não é diferente, uma vez que estes produtos necessitam de longos tempos de usinagem e polimento, consumindo de 60 a 80% dos custos finais de fabricação. Este trabalho tem como objetivo o estudo da influência de parâmetros de corte durante o fresamento frontal a seco do aço ferramenta VHSUPER nos estados recozido e temperado. Durante os testes foi avaliada a influência do substrato e revestimento das ferramentas, sendo uma de cermet e duas de metal duro revestido com TiCN + TiN e TiCN + TiN + Al2O3, além da velocidade de corte (vc) e avanço por aresta (fz) sobre vida das ferramentas, mecanismos de desgaste, rugosidade da peça, forças de usinagem e desvios dimensionais e geométricos. No caso específico do aço temperado também foi investigada a temperatura de usinagem. Os resultados obtidos durante a usinagem do aço recozido indicaram que, dentro da faixa de parâmetros utilizada, a vida das ferramentas caiu com a elevação da velocidade de corte, porém aumentou com o avanço. Vida mais longa de ferramenta foi obtida com o metal duro revestido com TiCN + TiN + Al2O3. No caso do aço temperado, tanto o aumento da velocidade de corte quanto o aumento do avanço resultaram em diminuição da vida das ferramentas, sendo que o metal duro revestido com TiCN + TiN foi o que apresentou melhores resultados. Os principais mecanismos de desgaste observados foram: desgaste abrasivo, adesão e perda do revestimento para o aço recozido. Para o aço temperado ocorreu perda do revestimento por desgaste e lascamento nas ferramentas de metal duro e lascamento na ferramenta cermet. Nas duas condições de dureza do aço, as superfícies com melhor acabamento foram obtidas com valores de avanço mais baixos, sem influência expressiva da velocidade de corte ou do material da ferramenta. Na análise dos fatores que influenciam as forças de usinagem, o avanço foi o fator mais expressivo, entretanto, a velocidade de corte foi o fator de maior influência sobre a temperatura de fresamento. Finalmente, tolerâncias dimensionais e geométricas mais estreitas foram obtidas após o fresamento discordante do aço no estado temperado.
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Silveira, Ricardo Cesar Alves. "Desenvolvimento de um equipamento mecânico com controle numérico computadorizado para produção de protótipos em escala." Universidade Federal de Minas Gerais, 2007. http://hdl.handle.net/1843/SBPS-7B6GRM.

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A produção de equipamentos mecânicos corresponde a uma parcela importante da geração de bens de capital. Para a melhoria da produtividade e respostas mais rápidas às necessidades técnicas, lança-se mão de protótipos em escala que podem ser utilizados na avaliação do design, propriedades mecânicas, aspectos de fabricação, desempenho e funcionalidade na produção de peças e ou conjuntos. A produção de protótipos físicos pode ser feita através da utilização de equipamentos mecânicos com comando numérico computadorizado. O objetivo deste trabalho foi o desenvolvimento de um equipamento mecânico controlado numericamente por computador (CNC) para produção de protótipos em escala, principalmente para fins didáticos. Tal equipamento mecânico poderá ser utilizado tanto no aprendizado em laboratório de sistemas CNC, quanto na criação de protótipos em escala para as áreas de Desenho Mecânico, Elementos de Máquinas e Projetos Mecânicos. Para o desenvolvimento do equipamento mecânico com controle por comando numérico utilizou-se um kit de controle numérico constituído de 03 motores a passo com encoders, controlador lógico em malha fechada (close loop), software CNC e mesa divisora com rotação (A). A concepção do equipamento mecânico foi feita a partir da avaliação de equipamentos disponíveis no mercado. O equipamento desenvolvido foi uma fresadora do tipo Router onde a mesa principal é fixa e o cabeçote de movimentação da ferramenta de corte pode transladar nos eixos X, Y e Z e girar em torno dos eixos B e C, conferindo maior possibilidade na confecção de superfícies complexas. O eixo de rotação (W) da ferramenta de corte corresponde ao mandril de uma micro-retífica Dremel® fixada no cabeçote de movimentação da ferramenta. Como filosofia de concepção e desenvolvimento dos componentes mecânicos do equipamento mecânico utilizou-se sistema mecânicos de mais fácil aquisição e fabricação convencional.
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Books on the topic "Sbp1"

1

Silva, Seitenfus Ricardo Antônio, and Sociedade Brasileira para o Progresso da Ciência. Reunião, eds. O Mercosul na SBPC. São Paulo, SP: Universidade de São Paulo, Instituto de Estudos Avançados, 1992.

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Rosas, Paulo. O discurso psicológico na SBPC. Recife, PE: Editora Universitária, UFPE, 1998.

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Habitação, Banco Nacional da, and Associação Brasileira das Entidades de Crédito Imobiliário e Poupança., eds. SBPE, censo nacional-1983: Cadernetas de poupança. Rio de Janeiro, RJ: Escola Nacional de Habitação e Poupança, 1985.

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Sociedade Brasileira para o Progresso da Ciência. Reunião. Resumos: Ciência, educação, investimento : SBPC 50 anos. [São Paulo, Brazil]: SBPC, 1998.

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Por uma nova política: Uma campanha na SBPC. Cotia, SP: Ateliê, 2003.

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Colorado. Dept. of Human Services., Rose Community Foundation, and Creative Leadership Solutions (Firm), eds. Alternatives to foster care: Prepared pursuant to SB01-211. [Denver: Colorado Dept. of Human Services, 2002.

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A construção da ciência no Brasil e a SBPC. Brasília, DF: CNPq, 1990.

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Sociedade Brasileira para o Progresso da Ciência. Reunião. SBPC cultural 2001: Bahia, Bahia, que lugar é este? [Salvador, Brazil]: Sociedade Brasileira para o Progresso da Ciência, 2001.

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Gryczynski, Edward S. SBP made easy: The survivor benefit plan. Alexandria, VA (201 N. Washington St., Alexandria 22314-2529): the Retired Officers Association, 1992.

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Sociedade Brasileira para o Progresso da Ciência. Reunião. 45a. Reunião Anual SBPC: Universidade Federal de Pernambuco, 11-16 julho 1993. [São Paulo, Brazil]: SBPC, 1993.

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Book chapters on the topic "Sbp1"

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Kashani, John, Richard D. Shih, Thomas H. Cogbill, David H. Jang, Lewis S. Nelson, Mitchell M. Levy, Margaret M. Parker, et al. "SBP." In Encyclopedia of Intensive Care Medicine, 2014. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_3291.

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Leung, Alexander K. C., Cham Pion Kao, Andrew L. Wong, Alexander K. C. Leung, Thomas Kolter, Ute Schepers, Konrad Sandhoff, et al. "SBP." In Encyclopedia of Molecular Mechanisms of Disease, 1891. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_6875.

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Duha, Shamsul, and Mohammad E. Rangiha. "Social Business Process Management (SBPM)." In Business Process Management Workshops, 85–95. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11641-5_7.

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Schiro, Adam J. "Spontaneous Bacterial Peritonitis (SBP)." In Liver Disorders, 519–29. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30103-7_31.

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Ginty, Annie T. "Systolic Blood Pressure (SBP)." In Encyclopedia of Behavioral Medicine, 2220. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_497.

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Ginty, Annie T. "Systolic Blood Pressure (SBP)." In Encyclopedia of Behavioral Medicine, 1952. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_497.

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Ginty, Annie T. "Systolic Blood Pressure (SBP)." In Encyclopedia of Behavioral Medicine, 1. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4614-6439-6_497-2.

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Westphal, Ulrich. "Sex Steroid-Binding Protein (SBP)." In Steroid-Protein Interactions II, 198–264. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-82486-9_7.

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Pardasani, R. T., and P. Pardasani. "Effective magnetic moment of [Ni(sbpd)2]." In Magnetic Properties of Paramagnetic Compounds, 3819. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23675-4_3469.

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Volkovich, Ilya. "The Untold Story of $$\mathsf {SBP}$$." In Computer Science – Theory and Applications, 393–405. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50026-9_29.

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Conference papers on the topic "Sbp1"

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Munegowda, Keshava. "SBP: Storage Benchmark Protocol." In 2022 4th International Conference on Circuits, Control, Communication and Computing (I4C). IEEE, 2022. http://dx.doi.org/10.1109/i4c57141.2022.10057795.

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Triaa, Wafa, Lilia Gzara, and Hervé Verjus. "A New Approach for SBPM based on Competencies Management." In 20th International Conference on Enterprise Information Systems. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0006704706730681.

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Tian, Yifan, Jiawei Yuan, and Shucheng Yu. "SBPA: Social behavior based cross Social Network phishing attacks." In 2016 IEEE Conference on Communications and Network Security (CNS). IEEE, 2016. http://dx.doi.org/10.1109/cns.2016.7860514.

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Lundquist, Tomas, and Jan Nordstrom. "The SBP-SAT Technique for Time-Discretization." In 21st AIAA Computational Fluid Dynamics Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2013. http://dx.doi.org/10.2514/6.2013-2834.

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Shen, Gangxiang, Yue Wei, and Qi Yang. "Shared Backup Path Protection (SBPP) in Elastic Optical Transport Networks." In Asia Communications and Photonics Conference. Washington, D.C.: OSA, 2012. http://dx.doi.org/10.1364/acp.2012.paf4c.6.

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Shen, Gangxiang, Yue Wei, and Qi Yang. "Shared Backup Path Protection (SBPP) in Elastic Optical Transport Networks." In Asia Communications and Photonics Conference. Washington, D.C.: OSA, 2012. http://dx.doi.org/10.1364/acpc.2012.paf4c.6.

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Limpert, Nicolas, Stefan Schiffer, and Alexander Ferrein. "A local planner for Ackermann-driven vehicles in ROS SBPL." In 2015 Pattern Recognition Association of South Africa and Robotics and Mechatronics International Conference (PRASA-RobMech). IEEE, 2015. http://dx.doi.org/10.1109/robomech.2015.7359518.

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Yu, Qiankun, Guolei Wang, Tianyu Ren, Xiaotong Hua, and Ken Chen. "Starting Base Position Optimization in Integrated Task Planning for Mobile Manipulators Painting Large Workpieces." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-70465.

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In order to paint large workpieces, heavy painting manipulators are always transported by mobile platforms due to their limited workspaces. To reduce the vibration of the end-effector, the base velocity of the manipulator is constant when painting. In this operation mode, the Starting Base Position (SBP) of the manipulator is important to attain the maximum manipulability and dexterity. This paper aims to optimize the SBP for painting a specified surface efficiently. An approximated decouplable model of painting manipulators is first built to get the analytically expressed inverse kinematic solutions. Then joint-level criteria for one manipulating point reflecting the manipulability and dexterity are proposed, followed by the combined criterion for a painting task about SBP with consideration of the platform velocity. Afterwards, the SBP optimization problem is translated into a least squares problem. To solve such a problem, an initial SBP value is first calculated through an algorithm based on internal penalty function method. Then a modified Levenberg-Marquardt method is employed to get the optimal SBP. Results of applications on painting a straight and an arc path indicate that the method proposed is effective and efficient.
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Ismail, Nor-Syahidatul N., Muhammad Ashraf Bin Zakaria, Nor Aishah Binti Muhammad, and Farizah Binti Yunus. "Smart Skim Pinjaman Buku Teks (SBPT) School Operation System in Malaysia." In 2021 IEEE International Conference on Automatic Control & Intelligent Systems (I2CACIS). IEEE, 2021. http://dx.doi.org/10.1109/i2cacis52118.2021.9495924.

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Balakit, Raymart B., Jennifer C. Dela Cruz, Rose Anne L. Reaño, Acer Jay G. Castillo, Christian Julius R. Garcia, Ma Caira Gail M. Libang, Joshua S. Mallapre, et al. "SB21: Portable Watermelon Ripeness Detector Through Acoustics Analysis and Spectral Identification." In 2022 IEEE 14th International Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment, and Management (HNICEM). IEEE, 2022. http://dx.doi.org/10.1109/hnicem57413.2022.10109373.

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Reports on the topic "Sbp1"

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Hong, J. K., H. J. Kim, I. Lee, and C. Kim. Sub-bottom profiler (SBP) survey. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2016. http://dx.doi.org/10.4095/297871.

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2

Wronosky, J. B. Sensor Based Process Control (SBPC) Laboratories Directed Research and Development (LDRD). Office of Scientific and Technical Information (OSTI), March 1993. http://dx.doi.org/10.2172/6588171.

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Agrawal, Asha Weinstein, Hilary Nixon, and Cameron Simmons. Investing in California’s Transportation Future: Public Opinion on Critical Needs. Mineta Transportation Institute, December 2020. http://dx.doi.org/10.31979/mti.2020.1861.

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In 2017, the State of California adopted landmark legislation to increase the funds available for transportation in the state: Senate Bill 1 (SB1), the Road Repair and Accountability Act of 2017. Through a combination of higher gas and diesel motor fuel taxes, SB1 raises revenue for four critical transportation needs in the state: road maintenance and rehabilitation, relief from congestion, improvements to trade corridors, and improving transit and rail services. To help state leaders identify the most important projects and programs to fund within those four topical areas, we conducted an online survey that asked a sample of 3,574 adult Californians their thoughts on how the state can achieve the SB1 objectives. The survey was administered from April to August 2019 with a survey platform and panel of respondents managed by Qualtrics. Quota sampling ensured that the final sample closely reflects California adults in terms of key socio-demographic characteristics and geographic distribution. Key findings included very strong support for improving all transportation modes, reducing air pollution and greenhouse gas emissions from transportation, and more convenient options to travel without driving. Respondents placed particular value on better maintenance for both local streets and roads, as well as highways. Finally, the majority of respondents assessed all types of transportation infrastructure in their communities as somewhat or very good.
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Ghosal, Samit, and Binayak Sinha. The cardiovascular benefits of GLP1-RA are directly related to their positive effect on glycaemic control: A meta-regression analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0071.

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Review question / Objective: P (patient population) = Type 2 diabetes patients with high CV risk or established atherosclerotic cardiovascular disease; I (intervention) = Received drugs: GLP1-RA; C (control group) = Compared to a control group that received a placebo; O (outcome) = Outcomes of interest included primary CV outcomes (MACE, CV death, MI, and Stroke). Condition being studied: To explore whether the heterogeneity associated with the primary outcomes benefits can be attributed to the metabolic improvements associated with GLP1-RA. The plan is to use HBA1c, weight, and SBP reduction as moderators attempting to explain any variance between the true and observed effect size.
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McElwain, Terry F., Eugene Pipano, Guy H. Palmer, Varda Shkap, Stephn A. Hines, and Wendy C. Brown. Protection of Cattle against Babesiosis: Immunization against Babesia bovis with an Optimized RAP-1/Apical Complex Construct. United States Department of Agriculture, September 1999. http://dx.doi.org/10.32747/1999.7573063.bard.

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Previous research and current efforts at control of babesiosis fall short of meeting the needs of countries where the disease is endemic, such as Israel, as well as the needs of exporting countries and countries bordering on endemic areas, such as the U.S. Our long-term goal is to develop improved methods of immunization against bovine babesiosis based on an understanding of the molecular mechanisms of immune protection and parasite targets of a protective immune response. In our previous BARD project, we established the basis for focusing on rhoptry antigens as components of a subunit vaccine against bovine babesiosis, and for additional research to better characterize rhoptry associated protein-1 (RAP-1) as a target of protective immunity. In this continuation BARD project, our objectives were to [1] optimize the immune response against RAP-1, and [2] identify additional rhoptry candidate vaccine antigens. The entire locus encoding B. bovis RAP-1 was sequenced, and the rap-1 open reading frame compared among several strains. Unlike B. bigemina, in which multiple gene copies with variant domains encode RAP-1, the B. bovis RAP-1 locus contains only two identical genes which are conserved among strains. Through testing of multiple truncated constructs of rRAP-1, one or more immunodominant T cell epitopes were mapped to the amino terminal half of RAP-1. At least one linear and one conformational B cell epitope have been demonstrated in the same amino terminal construct, which in B. bigemina RAP-1 also contains an epitope recognized by neutralizing antibody. The amine terminal half of the molecule represents the most highly conserved part of the gene family and contains motifs conserved broadly among the apicomplexa. In contrast, the carboxy terminal half of B. bovis RAP-1 is less well conserved and contains multiple repeats encoding a linear B cell epitope potentially capable of inducing an ineffective, T cell independent, type 2 immune response. Therefore, we are testing an amino terminal fragment of RAP-1 (RAP-1N) in an immunization trial in cattle. Cattle have beer immunized with RAP-1N or control antigen, and IL-12 with Ribi adjuvant. Evaluation of the immune response is ongoing, and challenge with virulent B. bovis will occur in the near future. While no new rhoptry antigens were identified, our studies did identify and characterize a new spherical body antigen (SBP3), and several heat shock proteins (HSP's). The SBP3 and HSP21 antigens stimulate T cells from immune cattle and are considered new vaccine candidates worthy of further testing. Overall, we conclude that a single RAP-1 vaccine construct representing the conserved amino terminal region of the molecule should be sufficient for immunization against all strains of B. bovis. While results of the ongoing immunization trial will direct our next research steps, results at this time are consistent with our long term goal of designing a subunit vaccine which contains only the epitopes relevant to induction of protective immunity. Parallel studies are defining the mechanisms of protective immunity. Apicomplexan protozoa, including babesiosis and malaria, cause persistent diseases for which control is inadequate. The apical organelles are defining features of these complex protozoa, and have been conserved through the evolutionary process, Past and current BARD projects on babesiosis have established the validity and potential of exploiting these conserved organelles in developing improved control methods applicable to all apicomplexan diseases.
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Eshed, Yuval, and Sarah Hake. Exploring General and Specific Regulators of Phase Transitions for Crop Improvement. United States Department of Agriculture, November 2012. http://dx.doi.org/10.32747/2012.7699851.bard.

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The transition of plants from a juvenile to adult growth phase entails a wide range of changes in growth habit, physiological competence and composition. Strikingly, most of these changes are coordinated by the expression of a single regulator, micro RNA 156 (miR156) that coordinately regulates a family of SBP genes containing a miR156 recognition site in the coding region or in their 3’ UTR. In the framework of this research, we have taken a broad taxonomic approach to examine the role of miR156 and other genetic regulators in phase change transition and its implication to plant development and crop improvement. We set to: Determine the common and unique factors that are altered upon juvenile to adult phase transition. Determine the functions of select miR156 target genes in tomato and maize, and identify those targets that mediate phase transition. Characterize the role of miR172 and its targets in tomato phase change. Determine the relationships between the various molecular circuits directing phase change. Determine the effects of regulated manipulation of phase change genes on plant architecture and if applicable, productivity. In the course of the study, a new technology for gene expression was introduced – next generation sequencing (NGS). Hence some of the original experiments that were planned with other platforms of RNA profiling, primarily Affymetrix arrays, were substituted with the new technology. Yet, not all were fully completed. Moreover, once the initial stage was completed, each group chose to focus its efforts on specific components of the phase change program. The Israeli group focused on the roles of the DELAYED SYMPODIAL TERMINATION and FALSIFLORA factors in tomato age dependent programs whereas the US group characterized in detail the role of miR156 (also termed Cg) in other grasses and in maize, its interplay with the many genes encoding miR172.
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