Journal articles: 'SARSCoV2'

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Hayakawa, Satoshi. "COVID-19 and SARSCoV2." Journal of Nihon University Medical Association 79, no. 1 (February 1, 2020): 47–49. http://dx.doi.org/10.4264/numa.79.1_47.

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Chivato Pérez, T. "Allergology and COVID19 pandemic." ANALES RANM 138, no. 138(02) (August 31, 2021): 132–36. http://dx.doi.org/10.32440/ar.2021.138.02.rev03.

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The COVID19 pandemic produced by SARSCOV2 has changed and impacted all areas of Medicine, including Allergology. Professionals and patients have seen how this virus has affected the daily routine at different levels. In this article three relevant aspects will be reviewed. First, the epidemiological, clinical, diagnostic, therapeutic and preventive measures differences between rhinitis due to SARSCOV2 infection and allergic rhinitis due to pollen sensitization are described. Second, the impact of new technologies and digital transformation on the daily routine of Allergology at the care and teaching level is reviewed. Finally, an update of the vaccines against SARSCOV2 is carried out from the point of view of safety for the allergic patient.

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Şteţca, Mădălina, Cristina Burlacenco, Andreea Ördög, and Nicoleta Tohănean. "PERIPHERAL NEUROLOGICAL COMPLICATIONS DURING COVID-19 PANDEMIC. SHORT REVIEW." Journal of School and University Medicine 09, no. 03 (2022): 20–23. http://dx.doi.org/10.51546/jsum.2022.9303.

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Covid-19 disruption has led to a dramatic loss of patients infected with SarsCov2 agent. With a well-reviewed vulnerability for the respiratory and cardiovascular systems, studies have expressed concern also for the neurological system. Lately, a number of cases regarding manifestations of central nervous- and peripheral nervous system have been reported, raising awareness of the high prevalence of prolonged neurological symptoms. Although affecting a smaller number of patients in comparison to central nervous system, the peripheral nervous system disorders have impacted the quality of patient’s life to a great extent. Infection with SarsCov2 has been connected with the development of several disorders like Guillain -Barre syndrome, or affection of cranial nerves with anosmia and disgeusia being the most encountered. Furthermore, exacerbation of symptoms involving already established disorders like CIDP and Miastenia Gravis have also been revealed. Nonetheless, neurological complications following vaccination against SarsCov2 infection cannot be omitted.

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Saha, Rajib. "Spectrum of SARSCOV2 infection with the efficacy of Covaxin and Covishield vaccines during third wave of COVID-19 pandemic: an experience of a densest state of India." International Journal of Research in Medical Sciences 10, no. 11 (October 28, 2022): 2633. http://dx.doi.org/10.18203/2320-6012.ijrms20222872.

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Background: Study was conducted to assess the trend or characteristic of SARSCOV2 infection during 3rd wave of pandemic and to compare the efficacy of Covaxin and Covishield Vaccines.Methods: This descriptive cross-sectional study was conducted with a mixed-method approach (Explanatory sequential mixed method) among the SARSCOV2 infected patients of West Bengal, India on the month of January 2022. In quantitative analysis 277 SARSCOV2 infected patients who were detected as COVID positive within January, were selected randomly from the secondary data source (collected by 20 general practitioners). In qualitative analysis, 11 patients from different categories were interviewed in-depth over the telephone to explain the quantitative data. Bivariate analysis (Mann Whitney U or Kruskal Wallis test) was used as per applicability. Kaplan Meir plot compared the efficacy of Covaxin and Covishield vaccines. Results: Most commonly presented symptom were low-grade fever (78.7%), a mild cough (41.9%), mild cold (62.4%), sore throat (41.9%), body ache (47.3%), and headache (33.2%). Few patients had experienced breathing difficulty (1.4%) and hospitalization (1.1%). Mann Whitney U test significantly (p<0.001) justified that Covaxin receivers have infected in late (median 161 days) comparison to other vaccines receivers (Covishield and Sputnik V median 129 days and 115 days respectively). This finding was also demonstrated in Kaplan Meir Plot.Conclusions: During the 3rd wave of the pandemic, SARSCOV2 infected patients commonly presented with milder symptoms, minimal hospitalization and without any case fatality. Delaying of infection has been observed more among Covaxin receivers compared to others.

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Hawaldar, Ranjana, Sadhna Sodani, Varsha Sodani, and R. K. Sodani. "Study of Seroprevalence of SARS CoV2 antibodies in children in a diagnostic centre of Central India-a retrospective study." Journal of Community Health Management 8, no. 4 (January 15, 2022): 176–80. http://dx.doi.org/10.18231/j.jchm.2021.039.

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It is said that children are less affected by SARSCoV2 infection because of their young immune system, so they have relatively milder symptoms as compared to adults. So the true incidence of SARSCoV2 is not known in this age group. Serosurveys in the paediatric age group can give a much better estimate of the incidence of SARSCoV2 infection in asymptomatic and symptomatic childrenThe present study was undertaken to study the seroprevalence of SARSCoV2 antibodies in children below 18 years of age, by measuring the S1RBD domain of spike protein neutralizing IgG antibody levels.This was a retrospective study carried out from August 2020 to August 2021 in a private diagnostic centre of Central India. 539 children of both genders from newborn babies upto 18 years of age were included in the study. US FDA Emergency Use Authorized [EUA], Atellica Solution SARS-CoV-2 IgG assay that detects anti S1-RBD antibodies including neutralizing IgG against SARS-CoV-2 was used for antibody estimation. Antibody level ≥1 was termed reactive or seropositive and below 1 were considered to be non reactive or seroneagtive There were 321 males and 218 females with a male to female ratio of 1.47 :1. 57% male children were seropositive while 61.9% female children showed seropositivity with an overall positivity rate of 58.99%.The findings of our study suggest that chidren below 5 years and adolescents exhibit higher antibody responses as compared to children between 5-10 years of age. The results of our study would be of help in formulating surveillance and vaccination strategies for children and in implementing public safety guidelines.

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Lemos de Souza Botelho, Joyce, Marta Duque de Oliveira, Nathan Alves de Souza, Ingred Gimenes Cassimiro de Freitas, Rosana Franciele Botelho Ruas, and Ana Izabel de Oliveira Neta. "Campanha de vacinação na Pandemia de SarsCov2: Relato de experiência." Nursing (São Paulo) 24, no. 272 (January 4, 2021): 5092–97. http://dx.doi.org/10.36489/nursing.2021v24i272p5092-5097.

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Objetivo: Evidenciar a relevância da participação de acadêmicos de enfermagem nas campanhas de imunização em meio à pandemia de SarsCov2. Método: Trata-se de um relato de experiência, estudo descritivo da atuação dos acadêmicos de enfermagem no período de maio, junho e julho de 2020, em pontos estratégicos de uma cidade do Norte de Minas Gerais nas campanhas de imunização contra influenza, tríplice viral e dupla viral. Resultado: Atuar na campanha de vacinação em uma pandemia possibilitou o entendimento de condições e barreiras a serem enfrentadas. Conclusão: A paramentação adequada possibilitou que o trabalho acontecesse de forma segura e contínua como previsto anualmente, lembrando que a rubéola, sarampo, caxumba e influenza ainda continuam presentes mesmo em momento de pandemia de SarsCov2.

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Maestroni, Georges. "Exogenous melatonin as potential adjuvant in anti-SarsCov2 vaccines." Journal of Neuroimmune Pharmacology 15, no. 4 (September 10, 2020): 572–73. http://dx.doi.org/10.1007/s11481-020-09956-1.

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Sediki, S., I. Tadmouri, and M. Hida. "ACUTE PANCREATITIS IN CHILDREN AND MULTISYSTEMIC INFLAMMATORY SYNDROME POST COVID INFECTION 19." International Journal of Advanced Research 10, no. 01 (January 31, 2022): 873–78. http://dx.doi.org/10.21474/ijar01/14119.

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During the SARSCoV2 pandemic children appear less likely to develop severe form Compared to adult subjects with higher contagiousness and mortality, especially in those at risk (age over 65 obesity cardiovascular disease diabetes). However a new multisystemic inflammatory syndrome associated with SARSCoV2 has been identified in the child associated with a cascade of inflammatory response responsible for clinical symptoms (prolonged high fever digestive disorders rash cheilite conjunctivit) and a highly disturbed inflammatory biological profile (high CRP accelerated sedimentation rate hyperferritinemia) mimicking an atypical post covid 19 Kawasaki syndrome in children as was recently published in the literature. Our case will illustrate an unusual presentation of post covid 19 multisystemic inflammatory Syndrome acute pancreatitis in a 9-year old with favorable clinical and biological development.

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Arshad, N., M. Ammad, A. Razzak, R. Ullah, Q. Ul Ain, M. Yousaf, S. Sajjad Naqvi, et al. "Detection of Mutations in SARS-CoV-2 Genomic Clades using COVIDSeq-NGS among International Travelers." American Journal of Clinical Pathology 158, Supplement_1 (November 1, 2022): S145. http://dx.doi.org/10.1093/ajcp/aqac126.308.

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Abstract Introduction/Objective Numerous SARS-CoV-2 variants/lineages have been identified based on genome sequencing. As of June 15, 2022 almost 11,399,573 whole genome sequences have been deposited in the GISAID-database. Severity and spread of COVID19 is based on their efficiency of infection and to multiply in host. That largely depend upon the structural mutation in spike, ORF and N proteins etc. That happens due to translation of genomic mutations during polypeptide synthesis. Also, the mutations are region/country specific. Specific mutation and combination of mutation causes the emergence of new strains. However, the strains can migrate from one region to other through travelers. The main objective of the current study is profiling of mutations in the genome of SARSCoV2 using Next- Generation-Sequencing (NGS) in international travelers and phylogenetic analysis of the sequences to find out different clades of SARSCoV2. Methods/Case Report A total of 557 SARSCoV2 genomes were sequenced on S4-sequencing flow-cell on NovaSeq 6000. For NGS of SARS-CoV-2 genome, Illumina, COVIDSeq kits and the protocols will be used strictly as recommended by the manufacturer. After NGS the analysis was done followed by FASTA sequences retrieval, mutations recording and phylogeny. Results (if a Case Study enter NA) This study reports 11 clades (19A, B, 20A, B, C, D, 20E; EU1, 20G, 20H; Beta V2, 20I: Alpha V1, 21D; and Eta) for the first time in international travelers. To best of our knowledge, this is the first report of the COVIDSeq approach for detection of mutation in SARSCoV2 genomic clades. The study revealed some dominants mutations was (Orf1a: P2018Q, K1053R, E176V, Orf1b: A520V, T2165A, S: D1127G, D614G, L18F etc. in other genes). Conclusion Profiling of common mutations among travelers could fill some gaps about the existence of SARS-CoV-2 variants information. However, further studies are needed to consolidate these findings before to be utilized for development of a potential therapeutic strategy.

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Shiraliyeva R.K., Huseynova S.Q., and Akhundov P.Y. "Covid 19-un nevroloji və psixoloji təzahürləri." NATIONAL JOURNAL OF NEUROLOGY, no. 18 (January 21, 2021): 19–25. http://dx.doi.org/10.28942/nnj.v2i18.301.

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Təqdim edilən ədəbiyyat icmalında COVID19un neyropsixoloji təzahürləri verilmişdir. Son aylar dərc edilən bir sıra məqalələrdə SARSCoV2 virusu ilə əlaqəli çoxsaylı nevroloji sindromlar barədə məlumatlar verilir. İcmalda COVID19 zamanı müşahidə edilən neyropisxoloji sindromların spektri və onların patofizioloji mexanizmlərinin müzakirəsi aparılmışdır.

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Mendoza Pruss, Jorge Rene, María Paola Zambrano Zambrano, Marcela Elizabeth Gómez Chumo, Ronald Steven Bravo Ávila, Jeffry Freddy Cedeño Moreira, and María Alejandra Marchán Matteucci. "Síndrome Inflamatorio sistémico asociado a SarsCov2. Revisión Bibliográfica y Actualización." RECIMUNDO 5, no. 2 (April 1, 2021): 238–47. http://dx.doi.org/10.26820/recimundo/5.(2).abril.2021.238-247.

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La enfermedad del Coronavirus 2019 (COVID-19) ha devastado a la comunidad mundial desde la aparición del síndrome respiratorio agudo severo coronavirus-2 (SARS-CoV-2) a fines de 2019. La mayoría de los casos de COVID-19 ocurren en adultos, y un subconjunto desarrolla síndrome hiperinflamatorio asociado a COVID-19, lo que resulta en enfermedad respiratoria progresiva y disfunción multiorgánica. La progresión a COVID-19 grave después de la exposición al SARS-CoV-2 es menos común en adultos jóvenes y niños. Sin embargo, desde marzo de 2020, las áreas con alta transmisión comunitaria de SARS-CoV-2 han informado un aumento de casos de síndrome inflamatorio pediátrico que ocurre semanas o meses después de la infección inicial asintomática o leve por SARS-CoV-2. En niños, el MIS-C también conocido como síndrome multisistémico inflamatorio pediátrico se asocia temporalmente con el SARS-CoV-2. Desde junio de 2020, se ha reconocido un síndrome similar (MIS-A) en adultos. La patología de MIS-C / A y su relación con la infección por SARS-CoV-2 aún no se conocen. La evidencia disponible sugiere una heterogeneidad significativa en la respuesta inmune humana al SARS-CoV-2. En este punto de vista, se examina el espectro de síndromes inflamatorios clínicos asociados con el SARS-CoV-2 identificado en poblaciones adultas y pediátricas hasta la fecha. Es necesario comprender mejor las inmunopatologías y las manifestaciones clínicas relacionadas de estos síndromes para mejorar su diagnóstico y tratamiento.

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AL-Obaidi, Zina F. H., and Abeer Ali Marhoon. "Molecular Study for Mutation of N-gene and S-gene COVID-19 Virus." International Journal for Research in Applied Sciences and Biotechnology 9, no. 1 (January 21, 2022): 34–44. http://dx.doi.org/10.31033/ijrasb.9.1.4.

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Thousands of individuals are affected every day by the current covid-19 pandemic, which is caused by a novel coronavirus called SARSCoV2. As a result, medicines and vaccines that are effective against all SARSCoV2 subtypes are critical today. Viral genome mutations are prevalent, and they can affect the encoded proteins, resulting in varying levels of detection and illness treatment effectiveness. Despite its clinical relevance, the SARS-CoV-2 gene set remains uncertain, making COVID-19 biology difficult to understand. A single type of mutation in the S gene that was changed the anticodon 614 from aspartic acid to glycine (D614G) consequence in increased virus infection. Herein, we report the gene mutation of structural proteins particularly spike and nucleocapsid proteins in viral genome. The overall prevalence of S and N gene mutations in SARS-CoV-2 were investigated. Among the structural proteins, our findings suggest that nucleocapsid had the highest mutation density, whereas Spike D614G was the most prevalent 93.9 %, found largely in genomes worldwide. These findings indicate that while designing diagnostics tools and therapeutic alternatives, the virus genotype in a certain community should be taken into account.

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Shorobura, M. S., T. I. Nehrych, N. L. Bozhenko, and N. O. Negrych. "Diagnosis and treatment of acute post-infection demyelinating disease. Case-study." Ukrainian Neurological Journal, no. 1—2 (July 1, 2022): 47–53. http://dx.doi.org/10.30978/unj2022-1-47.

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For almost 2 years, the SARSCoV2 pandemic has had a profound impact on the world of medicine and research. Research excitement caused by the new SARSCoV2 coronavirus may stimulate the study of demyelinating diseases (multiple sclerosis, acute disseminated encephalomyelitis acute), conversely, deepening our knowledge of the pathogenesis of demyelination and its association with viral infections may lead to studies in the immunopathogenesis of COVID19. Technological advances that have been rapidly mastered to combat SARSCoV2 may soon be used to address multiple sclerosis. A striking example is the potential use of mRNAbased technology to develop tolerant vaccines that suppress CNS autoimmunity. Clinical trials are already underway to evaluate IFNB, fingolimod, dimethyl fumarate, and masitinib (a tyrosine kinase inhibitor that is effective in phase 3 studies for primary progressive multiple sclerosis) as potent inhibitors of coronavirus. The study presents a clinical case of acute disseminated encephalomyelitis (ADEM) associated with SARSCoV2 in a 39yearold woman who was examined and treated at the Lviv Regional Clinical Hospital. The woman complained of severe dizziness, periodic numbness of the tongue, and snowlines of speech. From the anamnesis, it is known that from 07.05.2020 to 20.05.2020 she was treated for confirmed COVID19 infection in the Lviv Regional Infectious Diseases Hospital. Her condition was of moderate severity, she received an oxygen therapy. Neurological manifestations are horizontal nystagmus in both directions, high tendon and periosteal reflexes on all limbs, bilateral Babinski’s symptom, intentional tremor when performing a finger test on both sides. The diagnosis of demyelinating disease (possibly caused by COVID19) was established on the basis of serological studies (polymerase chain reaction to SARSCoV2), clinical findings, magnetic resonance imaging (multiple supra and infratentorial focal lesions of the white matter of the brain). The positive use of corticosteroids in the treatment of acute diffuse encephalomyelitis associated with SARSCoV2 has been reported. Thus, accurate diagnosis and timely treatment of acute demyelinating disease caused by SARSCoV2 virus are of great clinical importance.

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Selina, Farhana, Khandaker Abu Talha, Mostafa Taufiq Ahmed, Ishrat Jahan Karim, Morshed Nasir, Sonia Latif, Rawshan Ara Perveen, and Ramanuj Bhattacharya. "The Neurological and Neurosurgical Presentations of SARSCoV2 Affected Patients: A Systematic Review." Bangladesh Journal of Neurosurgery 10, no. 2 (June 5, 2021): 169–74. http://dx.doi.org/10.3329/bjns.v10i2.53770.

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Presentation with neurological complaint is not very uncommon. Few patients report with intracerebral hemorrhage which are considered as cases of neurosurgical intervention, on the other hand respiratory depression and encephalitis patients need care in Neurosurgical intensive care unit (Neurosurgical ICU) for treating or measuring intracranial pressure (ICP). This systematic review includes 2683 COVID- 19 patients of 17 articles who had neurological manifestations. Out of these 17 studies 8 articles were retrospective case series, 3 were prospective case series, 3 were case reports, 2 were cross-sectional and 1 cohort study. Headache was commonest neurological feature presented in 7 studies. Cerebro-vascular problem, loss of smell and impaired conscious level was present in four studies each. Seizure was presenting feature in 3 studies. There were series where patients reported with loss of taste. Other presenting features were dizziness and ataxia. Previous studies supported that Corona virus can cause encephalitis, multiple sclerosis or cerebral hemorrhage. Respiratory failure due to damage of cardiorespiratory center of brainstem by COVID- 19 virus has not been ruled out. Bang. J Neurosurgery 2021; 10(2): 169-174

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Rodríguez-Blanco, Noelia, Irene Vegara-Lopez, Loreto Aleo-Giner, and José Tuells. "Scoping review of coronavirus case series (SARS-CoV, MERS-CoV and SARS-CoV-2) and their obstetric and neonatal results." Revista Española de Quimioterapia 33, no. 5 (July 20, 2020): 313–26. http://dx.doi.org/10.37201/req/064.2020.

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Background. The appearance of new infectious diseases, such as COVID-19, poses a challenge in monitoring pregnancy and preventing obstetric and neonatal complications. A scoping review has the objective to review the information available in pregnant women infected with the MERS-CoV, SARSCoV, SARS-CoV-2 coronaviruses to assess the similarities in terms of and differences in the clinical characteristics of the mothers and neonatal outcomes. Methods. We carried out a bibliographic search (scoping review) according to the PRISMA guidelines between March and April 2020 in the MEDLINE, SciELO, and CUIDEN databases and the Elsevier COVID-19 Information Center. Results. We analyzed 20 articles with a total of 102 cases. 9 of MERS-CoV, 14 of SARS-CoV and 79 of SARS-CoV-2. Fever (75.5%) and pneumonia (73.5%) were the most frequent symptoms in infected pregnant women. The most frequent obstetric complications were the threat of premature delivery (23.5%) and caesarean section (74.5%). No vertical transmission was documented in any of the infants. Conclusions. All three coronaviruses produce pneumonia with very similar symptoms, being milder in the case of SARSCoV2. Despite documented obstetric complications, neonatal outcomes are mostly favorable. Increased knowledge is needed to improve and prevent obstetric and neonatal complications from these infections in pregnant women.

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Foratori-Junior, Gerson Aparecido, Victor Mosquim, Thais Marchini de Oliveira Valarelli, Maria Aparecida de Andrade Moreira Machado, and Silvia Helena de Carvalho Sales-Peres. "COVID-19 and its relation to pregnancy and neonates: a systematic review." Revista Brasileira de Saúde Materno Infantil 21, no. 3 (July 2021): 697–727. http://dx.doi.org/10.1590/1806-93042021000300002.

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Abstract Objectives: this study systematically reviewed the literature in order to better understand the association among COVID-19, pregnancy and neonates. Methods: MEDLINE, EMBASE, Web of Science, BVS and SCOPUS were assessed, considering the terms: (covid 19 OR covid-19 OR novel coronavirus OR 2019 novel coronavirus OR 2019-nCoV OR sarscov 2 OR sars-cov-2 OR sarscov2 OR sars cov-2) AND (pregnancy OR pregnant OR pregnant women OR gestation OR gestational) AND (infant OR fetal OR neonatal). Thirty full-text were included (408 pregnant women, 11 non-pregnant women and 279 neonates). Results: fever (45.83%) and cough (31.61%) were the main symptoms of COVID-19 during the pregnancy. Low levels of lymphocytes (32.10%), elevated levels of C-reactive protein (32.35%); leukocytosis (29.41%); neutrophil (5.88%); and radiographic alterations on chest CT, x-ray or ultrasound (45.84%) were the main laboratorial findings. Cesarean delivery and preterm were registered in 239 and 49 cases, respectively. Ten neonates tested positive for SARS-CoV-2. Conclusion: when COVID-19 pneumonia affects women during pregnancy, the symptoms are similar to those experienced by non-pregnant women. In addition, there is still no plausible evidence suggesting vertical transmission of SARS-CoV-2 virus from mother to child.

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R. PREETHY, U. SUNDERESH KAMAL CHANDER, D. ARUNA, MUTHUVEL E, and SONTI SULOCHANA. "A SPECTRUM OF BACTERIAL SEPSIS IN COVID -19 POSITIVE AND NON COVID -19 PATIENTS – AN INDIAN MONOCENTER RETROSPECTIVE STUDY." Asian Journal of Microbiology, Biotechnology & Environmental Sciences 24, no. 04 (2022): 751–56. http://dx.doi.org/10.53550/ajmbes.2022.v24i04.022.

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–This study aims to determine spectrum of bacterial infection in patients with severe acute respiratory syndrome coronavirus-2 infection at the time of hospital admission and identify changes in hematological biomarkers of COVID19 severity. A retrospective study was conducted in blood cultures from patients suspected to have sepsis were included in the study. Patients were grouped based on SARS-CoV2 RT-PCR result as positive, negative, or not tested. For the purposes of classifying blood cultures by SARSCoV-2 RT-PCR status, hematological parameters were analyzed. Out off 825 blood sample, 466 samples was positive for blood culture identified by conventional and Automatic blood culture system – Vitek 2. Among these 466 patients, 211(45.2%) were positive for SARS-CoV2 virus and 255 (54.7%) were negative for SARSCoV2 virus by RT -PCR. Regarding CRP Total number of CRP positive samples was 654, CRP negative samples was 84 and CRP was not done for 87samples. The total number of IL6 positive samples was 83 and IL6 negative samples were not evaluated for 125 patients. The concern of Bacterial sepsis in COVID-19 patients due to the above organisms based on our study over the period of one year. Consequently, it is important to pay attention to bacterial co-infections in critical patients diagnosed for COVID-19.

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Richeux, J., R. Magnier, A. Mouadil, Y. Oulkhouir, K. Campbell, H. Fouquet, N. Aide, et al. "Séquelles fonctionnelles, vasculaires et parenchymateuses à 6–9 mois d’une infection au SarsCov2." Revue des Maladies Respiratoires Actualités 14, no. 1 (January 2022): 137–38. http://dx.doi.org/10.1016/j.rmra.2021.11.207.

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Villaseca Carrasco, Nicolás, and Raúl Villaseca Carrasco. "Ventilador mecánico no invasivo para atención domiciliaria." Revista de investigación de Sistemas e Informática 14, no. 2 (February 28, 2022): 5–14. http://dx.doi.org/10.15381/risi.v14i2.23146.

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La infección por SarsCov2 produce el síndrome de distrés respiratorio severo, que lleva a la muerte. El año 2020, durante la epidemia Covid-19 se esperaba y ocurrió que en todos los hospitales colapsaran las unidades de cuidados intensivos (UCI), muchos pacientes murieron esperando tener acceso a un ventilador mecánico. En ese contexto nosotros logramos desarrollar un equipo que puede proporcionar asistencia ventilatoria no invasiva a los pacientes afectados, dándoles una oportunidad. Presentamos nuestros resultados, los mismos que no pudieron ser validados en modelos biológicos experimentales.

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Gomes e Costa, Durval Alex, Marli Sasaki, Marcelo Mileto Mostardeiro, Catia Cristina Carpinelli, Daniel Litardi Pereira, Pedro Saliba e Borges, Rafael Correa Barros, Samylla Costa de Moura, Andrea Lucia Silva Ladeira Almeida, and Augusto Yamaguti. "IMPACTO DE VACINAÇÃO CONTRA SARSCOV2 EM PACIENTES HOSPITALIZADOS POR COVID19 ACIMA DE 60 ANOS." Brazilian Journal of Infectious Diseases 26 (January 2022): 101800. http://dx.doi.org/10.1016/j.bjid.2021.101800.

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Martinez, Lorena, Nancy Y Portela, Nelson R Campos, Jose R Urrego, Karol A Mendez, Danny Wilson Sanjuanelo Corredor, and Claudia Patricia Tacuma Prada. "Knowledge, attitudes and practices in health personnel who provide care to patients with SARSCOV2." International Journal of Family & Community Medicine 6, no. 6 (December 7, 2022): 324–29. http://dx.doi.org/10.15406/ijfcm.2022.06.00298.

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Objective: To identify knowledge, attitudes and practices in health personnel who provide care to patients with SARS-COV2. Materials and methods: A cross-sectional, descriptive study was carried out that included 362 participants, discriminated against health professionals (213) and health technicians (149) who provided first-line health services for the care of suspected or positive patients for SARS Cov 2, the technique Sampling was at convenience, the questionnaire they answered to participate was self-completed electronically using the Google Docs tool after designing, validating and applying a KAP (Knowledge, Attitudes and Practices) survey. An analysis with descriptive statistics was performed, bivariate associations were made using the Chi-square test where p<005 was taken as the level of significance. Results: In the KAP (Knowledge, Attitudes and Practices) survey, factors, protective and risk behaviors emerged; In these results, it is important to highlight that some of them vary in the responses of the participants, because what for some may constitute a risk factor or behavior, for others it may be a risk or protective factor. Conclusion: For the participants Having security in knowledge, personal coping resources, availability of personal protection elements and resources for care, at the time of carrying out the interventions in the patients they become protective behaviors, and the participants' perception of risk was influenced by values, beliefs, feelings, knowledge and their sources. It is important to highlight that some of them vary in the responses of the participants, because what for some may constitute a risk factor or behavior, for others it may be a risk or protective factor. conclusions. For the participants Having security in knowledge, personal coping resources, availability of personal protection elements and resources for care, at the time of carrying out the interventions in the patients they become protective behaviors, and the participants' perception of risk was influenced by values, beliefs, feelings, knowledge and their sources. It is important to highlight that some of them vary in the responses of the participants, because what for some may constitute a risk factor or behavior, for others it may be a risk or protective factor. conclusions. For the participants Having security in knowledge, personal coping resources, availability of personal protection elements and resources for care, at the time of carrying out the interventions in the patients they become protective behaviors, and the participants' perception of risk was influenced by values, beliefs, feelings, knowledge and their sources.

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Muhammad Ilham Hardian and Bertha Rusdi. "Studi Bioinformatika Mutasi Genetik pada Gen Pengkode Protein Spike dari Virus Sars-Cov-2 di Indonesia." Bandung Conference Series: Pharmacy 1, no. 1 (December 19, 2021): 18–23. http://dx.doi.org/10.29313/bcsp.v1i1.89.

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Abstract. SARS-CoV-2 is a new type of virus that causes the current pandemic. Corona virus gene mutations have become popular since the discovery of SARS-CoV-2 variants in the UK (B.1.1.7), South Africa (B.1.351), India (B.1.617.1 and B.1.617.2). The purpose of this study was to analyze the genetic mutations of L452R and N501Y in SARS-CoV-2 virus isolates found in Indonesia to obtain an overview of their role in the ACE2 receptor binding site. The benefits of this research are expected to provide scientific information regarding genetic mutations of SARS-CoV-2 isolates that are useful for vaccine development and various other studies. A bioinformatic study that began with the search for the sequence of genes encoding the SARSCoV2 protein S that had mutations from Indonesian patient isolates on the Global Initiative on Sharing All Influenza Data (GISAID) page. Furthermore, the SARSCoV2 genome sequence that was first reported in Wuhan (Wuhan-1) was extracted from the National Center for Biotechnology Information (NCBI) page for comparison. The sequence of the gene encoding the protein S that had been obtained by GISAID was compared to the sequence of the gene encoding the protein S of the Wuhan-1 isolate using the Clustal Omega software. To compare the amino acid sequences of these isolates, the Coding Sequences (CDS) of protein S of the wuhan-1 isolate were translated into amino acid sequences using Skaminsky115. The nucleotide and amino acid sequences of protein S that have been obtained are then analyzed to map the position of RBD related to the mutation that occurs. The results of the study are genomic data that have been carried out by aligning the amino acid sequences of several Indonesian isolates and Wuhan-Hu-1 isolates. Then found mutations in the sequence of DNA bases and amino acid bases that are thought to be in the area around the RBD, namely in the order of (471, 472, 478, 480, 534). Abstrak. SARS-CoV-2 merupakan jenis virus baru penyebab pandemi saat ini. Mutasi gen virus corona menjadi populer semenjak ditemukannya varian SARS-CoV-2 di Inggris (B.1.1.7), Afrika Selatan (B.1.351), India (B.1.617.1 dan B.1.617.2). Tujuan dari penelitian ini adalah menganalisis mutasi genetik L452R dan N501Y pada isolat virus SARS-CoV-2 yang ditemukan di Indonesia untuk mendapatkan gambaran terhadap perannya pada daerah pengikatan reseptor ACE2. Manfaat penelitian ini diharapkan dapat memberikan informasi ilmiah mengenai mutasi genetik isolat SARS-CoV-2 yang berguna untuk pengembangan vaksin dan berbagai penelitian lainnya. Studi bioinformatik yang diawali dengan pencarian urutan gen pengkode protein S SARSCoV2 yang mengalami mutasi dari isolat pasien Indonesia pada laman Global Initiative on Sharing All Influenza Data (GISAID). Selanjutnya urutan genom SARSCoV2 yang dilaporkan pertama kali di Wuhan (Wuhan-1) diekstrak dari laman National Center for Biotechnology Information (NCBI) untuk dijadikan pembanding. Urutan gen pengkode protein S yang telah diperoleh dr GISAID dibandingkan terhadap urutan gen pengkode protein S isolat Wuhan-1 menggunakan perangkat lunak Clustal Omega. Untuk membandingkan urutan asam amino isolat-isolat tersebut, Coding Sequens (CDS) protein S isolat wuhan-1 diterjemahkan menjadi urutan asam amino menggunakan Skaminsky115. Urutan nukleotida dan asam amino protein S yang telah diperoleh kemudian dianalisis untuk memetakan posisi RBD berkaitan dengan mutasi yg terjadi. Hasil penelitian berupa data genomik yang telah dilakukan penyejajaran urutan asam amino dari beberapa isolat Indonesia dan isolat Wuhan-Hu-1. Kemudian ditemukan mutasi pada urutan basa DNA dan basa asam amino yang diduga berada pada daerah sekitar RBD yaitu pada urutan ke-(471, 472, 478, 480, 534).

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Fibrans, William Picolo, and Ana Paula Coelho Abreu dos Santos. "O DIREITO À SAÚDE NA CONSTITUIÇÃO BRASILEIRA: FERRAMENTAS DO SUS PARA ENFRENTAR A PANDEMIA DO SARS CoV2." Revista de Direito Sociais e Políticas Públicas 7, no. 1 (August 20, 2021): 163. http://dx.doi.org/10.26668/indexlawjournals/2525-9881/2021.v7i1.7902.

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Aborda-se o tema do combate à Pandemia do SarsCoV2 no Brasil, tendo como filtro a Constituição Federal de 1988 e o Sistema Único de Saúde (SUS). Objetiva demonstrar a importância do SUS, analisar o papel das políticas públicas no enfrentamento da Atual Crise Sanitária, além de responder à problemática proposta. A pesquisa identificou a possibilidade de aplicar uma política pública capaz de controlar a Pandemia no âmbito brasileiro, obtendo-se eficácia pelos caminhos indicados ao decorrer do desenvolvimento e conclusão. Esta última, demonstrando o atendimento dos objetivos propostos, com solução para o problema apresentado.

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Sawarkar, Siddhant, and Sapan Jaiswal. "Ophthalmic Manifestation of COVID-19 Disease." ECS Transactions 107, no. 1 (April 24, 2022): 17933–40. http://dx.doi.org/10.1149/10701.17933ecst.

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Coronavirus is the novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). It's a non-segmented enveloped positive sense RNA virus with 82 percent genetic similarity to the SARS coronavirus (SARSCoV), which sparked an outbreak in early 2003. Respiratory droplets are assumed to be the primary mechanism of transmission because the virus is found in respiratory secretions. Conjunctival transmission and aerosol transmission have also been proposed, however they are also problematic. Fever, tiredness, and dry mouth are the three most prevalent COVID-19 clinical symptoms. In several patients, however, conjunctivitis was the initial symptom. The disease's respiratory complications have been the focus of diagnostic and therapeutic efforts, However, a number of ocular concerns have surfaced. Infected patients' tears have been confirmed to contain SARSCov2 RNA, and studies indicate that the virus is spreading. For viral transmission, the ocular surface could serve as both an entry point and a reservoir. COVID-19 has been linked to mild conjunctivitis, which can be the disease's first and only symptom. Ocular symptoms can be treated with observation without therapy, antibacterial eye drops, antiviral eye drops, and antiallergic eye drops, according to clinical trials. As a result, the only recommended treatment for COVID-19 related ocular manifestations is close observation. The motivation behind this examination was to investigate the event of visual appearances in patients who had been determined to have COVID illness 2019 (coronavirus) because of serious intense respiratory condition.

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Bhagat, Shweta, and Yash Hada. "Mystery of Shedding Coronavirus in Tears of Patients Affected with COVID-19." ECS Transactions 107, no. 1 (April 24, 2022): 17899–906. http://dx.doi.org/10.1149/10701.17899ecst.

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The severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) caused 2019 new coronavirus illness (COVID-19) has spread globally, causing a pandemic. The WHO declared the outbreak a pandemic on January 31, 2020. 2020 has been marked as COVID pandemic year. SARSCoV2 caused a global outbreak of this infectious disease. A number of cases has continued to rise since then. Coronavirus is a highly infectious disease spread mostly by respiratory droplets and direct contact with affected individuals. Viral isolation and quantitative reverse-transcription polymerase chain reaction (RT-PCR) analysis confirm the diagnosis. While the pathways of virus transmission are still debated, several investigations have been conducted to identify tear film and conjunctiva as the mode of virus transmission. Multiple case reports have surfaced in which ophthalmic doctors were found to be infected during routine management. From January 26 to February 9, 2020, 30 confirmed novel coronavirus pneumonia (NCP) patients were recruited for a prospective interventional case series investigation at Zhejiang University's first affiliated hospital. Tear and conjunctival secretions were collected twice with disposable sample swabs at a 2-to-3 day interval for the reverse transcription polymerase chain reaction assay. Twenty-one individuals with NCP of the common type and nine patients with NCP of the severe kind were included in the study. The lone patient with conjunctivitis had two samples of tear and conjunctival secretions, both of which generated positive RTPCR results. A total of 58 samples from different patients were found to be negative.

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Leme, Jaci, and Thaissa Consoni Bernardino. "AVALIAÇÃO DO CRESCIMENTO DE CÉLULAS VERO EM SISTEMA PSEUDO AGITADO COM MICROCARREGADORES CYTODEX 1." Revista Multidisciplinar de Educação e Meio Ambiente 2, no. 4 (October 20, 2021): 1–6. http://dx.doi.org/10.51189/rema/2003.

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Células Vero são utilizadas para o desenvolvimento de vacinas virais, aprovadas para uso humano, incluindo assim uma vacina contra o vírus SARSCoV2. Nosso objetivo foi estabelecer um protocolo de produção para esta condição de cultivo. As células cultivadas em frasco spinner foram testadas em diferentes concentrações. Os valores de μmax permitem observar que o melhor desempenho foi com o ensaio cujo valor ficou em 0,0334 h1. A duplicação celular ocorreu em 1= 37,47 h, 2= 21,15 h e 3= 22,29 h. A concentração e a qualidade do inóculo são determinantes para o desempenho das células quando cultivadas em sistema pseudo agitado com microcarregadores.

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Gómez Avila, Niyireth, Silvia Raquel Rodriguez Montoya, Claudia Ramirez Fajardo, Dunia Ximena Paredes Aguirre, and Nataly Esmeralda Rojas Giron. "Hipoacusia Neurosensorial Súbita y COVID 19:." Areté 20, no. 2 (December 16, 2020): 43–52. http://dx.doi.org/10.33881/1657-2513.art20205.

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La enfermedad por COVID 19 es una infección viral causada por el agente etiológico SARS Cov 2; presenta una gama de características clínicas incluyendo síntomas neurológicos, afectando neuronas, células gliales y nervios; formando parte del grupo de etiología de la hipoacusia neurosensorial. Se realiza este reporte de caso de hipoacusia súbita neurosensorial unilateral acompañada de tinnitus en paciente con antecedente de SARSCov2 Positivo, describiendo los principales hallazgos otológicos y audiológicos en el proceso de evaluación diagnóstico. La afectación por el virus nCoV-19 tiene incidencia en la pérdida auditiva, como se describe en estudios de casos reportados internacionales.

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Musa, Hassan, Taha H. Musa, Idriss H. Musa, and Olayinka Oderinde. "Letter to Editor COVID-19 outbreak and medical waste: Challenge in hand." International Journal of Public Health Science (IJPHS) 9, no. 3 (September 1, 2020): 153. http://dx.doi.org/10.11591/ijphs.v9i3.20523.

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The ongoing pandemic of novel coronavirus disease, COVID19, which first reported in Wuhan, China, inDecember 2019, [1] and caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV2) has resulted to more than 6,881,352 confirmed cases in the world, and 399,895 global deaths, as reported in 8:36am CEST, 8 June 2020. [2] It has been reported that the primary spread of COVID-19 via human transmission is during close contact, most often through small droplets spread by coughing, sneezing, and talking. [3] Researchers and health experts have discovered that wearing of appropriate face masks can significantly reduce the transmission up to the 75%.

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Stirparo, L., F. Autore, I. Innocenti, E. Papa, F. Marchesi, C. Togni, S. Mariani, et al. "P1353: EFFICACY OF SARSCOV2 VACCINATION IN PATIENTS UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION. A MULTICENTER EXPERIENCE." HemaSphere 6 (June 2022): 1238–39. http://dx.doi.org/10.1097/01.hs9.0000848276.50247.d2.

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Dixon, Dalia. "RNA Sensors as a Mechanism of Innate Immune Evasion among SARSCoV2, HIV and Nipah Viruses." Current Protein & Peptide Science 22, no. 4 (2021): 273–89. http://dx.doi.org/10.2174/18755550mte0gotk15.

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Miranda Solís, Edwin Marcelo, José Alexander Ayala López, Patricia Alexandra Heredia Calvopiña, and Richard Eduardo Morales Cumbajín. "Neumotórax espontáneo secundario a bullas enfisematosas como secuela de Covid-19 severo: reporte de caso." Anatomía Digital 4, no. 4 (December 3, 2021): 129–40. http://dx.doi.org/10.33262/anatomiadigital.v4i4.1938.

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Introducción: en diciembre del 2019, un nuevo virus respiratorio de la familia de los coronavirus fue identificado en la provincia de Wuhan China, rápidamente se extendió a nivel mundial causando un impacto en la morbimortalidad global. Presentamos el caso de neumotórax espontáneo en un paciente post-COVID 19 severo, llama la atención el escaso número de casos reportados con este tipo de complicaciones. Metodología: presentación de un caso clínico, estudio descriptivo, retrospectivo. Objetivo: describir un caso clínico de neumotórax espontáneo secundario a bullas enfisematosas en un paciente que presentó infección respiratoria severa por SARSCOV2. Resultados: paciente masculino, de 66 años de edad sin antecedentes patológicos de importancia, no reporta exposición a carburantes de biomasa o tabaco, ingresó al área de aislamiento respiratorio de un centro asistencial para pacientes COVID – 19 de la Ciudad de Ambato – Ecuador por presentar clínica respiratoria de varios días de evolución, confirmando mediante RT – PCR cuadro de neumonía por COVID 19, se catalogó como afectación severa luego de la valoración radiográfica pulmonar por lo cual tuvo una estancia prolongada, egresando con importantes secuelas pulmonares del tipo neumopatía intersticial secundaria a infección por SARSCOV2 por lo que requirió oxígeno domiciliario a su egreso. Luego de más de 20 días del alta hospitalaria reingresa por nuevo cuadro de insuficiencia respiratoria aguda. Luego de descartar infección respiratoria nosocomial y tromboembolia pulmonar se identifica neumotórax espontáneo como causante de los síntomas, evolucionando favorablemente luego de la colocación de tubo torácico y terapia respiratoria domiciliaria. Conclusiones: las complicaciones tempranas y tardías secundarias a COVID 19 son un tema de vital importancia dentro del ámbito hospitalario y del manejo en general de este tipo de pacientes. Una adecuada valoración y oportuna intervención en los pacientes con afectación severa secundaria a esta patología es fundamental para reducir la morbimortalidad por el virus.

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Wariah, Uway, Nelly Apriningrum, Dany Aulia, Muhammad Arief Setiawan, Oon Sopiah, Achmad Fariji, and Riska Setiawati. "Pengaruh Sikap Terhadap Intensi Berperilaku Melakukan Cuci Tangan Pada Lanjut Usia Di Masa Pandemi COVID-19." Jurnal Ilmu Kesehatan Immanuel 16, no. 1 (August 12, 2022): 43–46. http://dx.doi.org/10.36051/jiki.v16i1.179.

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Mencuci tangan merupakan upaya yang mudah dan murah dalam pencegahan infeksi, diantaranya dengan pencegahan penyebaran SarsCov2. Penelitian ini bertujuan menganalisa pengaruh sikap terhadap intensi berperilaku cuci tangan bagi lansia pada masa pandemi covid 19 di Wilayah kerja Puskesmas Telagasari Tahun 2020. Metode dalam penelitian ini adalah penelitian kuantitatif deskriptif analitik dengan pendekatan cross sectional. Jumlah populasi penelitian ini 8920 lansia di wilayah kerja Puskesmas Telagasari Tahun 2020 dan sampel penelitian sebesar 382 orang yang diperoleh dengan metode stratified random sampling. Hasil analisis data menunjukkan bahwa terdapat pengaruh signifikan antara sikap dan intensi dengan nilai r = 0.419 dan p = 0.000. Kesimpulanya terdapat pengaruh sikap terhadap intensi melakukan cuci bagi lansia pada masa pandemi covid 19.

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Pakpahan, Elvira Fitriyani, Willy Alfrio Saragih, Beny Pangaribuan, and Tonggi Sidabutar. "PERAN PEMERINTAH KOTA MEDAN TERHADAP PENANGANAN WABAH COVID-19." Jurnal Darma Agung 30, no. 2 (July 14, 2022): 98. http://dx.doi.org/10.46930/ojsuda.v30i2.1575.

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Penelitian ini bertujuan meneliti tentang Langkah-Langkah Strategi yang dilakukan Pemerintah Kota Medan dalam Penanganan wabah covid-19 di Kota Medan. Covid-19 merupakan penyakit yang penyebabnya teridentifikasi pada virus Corona yang menyerang saluran pernapasan. Corona pertama kali muncul di Wuhan, China. Penyebab virus Covid19 adalah SARSCoV2. Metode penelitian memberikan gambaran tentang desain penelitian yang meliputi antara lain: prosedur dan langkah-langkah yang akan dilakukan, waktu, sumber data dan langkah-langkah studi untuk mendapatkan tanggal genap. Virus Covid-19 adalah penyakit yang mengakibatkan kesehatan masyarakat jadi darurat, oleh karena itu tindakan pencegahan harus segera dilakukan. Kemudian, pemerintah mendeklarasikan darurat kesehatan masyarakat dan mengambil tindakan social distancing berskala besar sebagai cara untuk merespons darurat kesehatan masyarakat, selain itu pemerintah sendiri tetap harus memilih dan memilih.

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Czarnecka-Czapczyńska, Magdalena, Dorota Bartusik-Aebisher, Magdalena Krupka-Olek, David Aebisher, Grzegorz Cieślar, Wojciech Latos, and Aleksandra Kawczyk-Krupka. "Coagulation markers in diagnostic and monitoring of thromboembolic complication in COVID-19." European Journal of Clinical and Experimental Medicine 19, no. 3 (2021): 241–45. http://dx.doi.org/10.15584/ejcem.2021.3.5.

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Introduction. Coronavirus disease 2019 (COVID-19) was first observed in China in Wuhan city, Hubei province in December, 2019, and specified as a pandemic by the World Health Organization (WHO). COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2). Aim. The aim of this article is to discuss epidemiology of thromboembolic complication in COVID-19. Material and methods. This article is a review done in regards to discuss clinical features of the anticoagulation treatment in COVID-19. Analysis of the literature. A review is discussed an anticoagulation treatment in 41 manuscripts. Conclusion. Most commonly coagulation abnormalities in patient with COVID-19 is mild thrombocytopenia. Apart from their typical role in thrombosis and hemostasis, platelets mediate key aspects of immune and inflammatory.

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M. Hamouda, Ibrahim. "Clinical Management and Awareness of Covid-19 ‘SARS-coV-2’ Among Faculty members, Department of Eastern Medicine and peoples of Faisalabad." International Journal of Clinical Case Reports 1, no. 1 (October 24, 2022): 01–11. http://dx.doi.org/10.31579/2834-8389/001.

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COVID 19 a plague that has been spread worldwide in a brief time period. It is a sickness caused by contamination with the newly localized coronavirus "SARScoV2". Health specialists appreciate and tried for offerings that are near most people, irrespective of the chance of contamination. Consequently, in such situations, it ought to be essential to evaluate the statistics and views of medical specialists and numerous human beings particularly this pandemic and speak the effect of this catastrophe on psychosocial balance. The usual educational intervention sand schooling packages for COVID 19 pollutants manipulation and practices in all healthcare specialists are lacking, place of work fitness and safety are paramount to reducing the chance of transmission to students, healthcare experts and healthcare experts.

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Mouhcine, Mohammed, Youness Kadil, and Houda Filali. "The Preliminary Identification of Potential Vaccine Targets for SARSCoV2 and Computer-aided Synthesis ("Small Interfering RNA Design")." Current Enzyme Inhibition 16, no. 3 (November 4, 2020): 238–42. http://dx.doi.org/10.2174/1573408016999200624153546.

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Introduction: Coronaviruses constitute the subfamily Orthocoronavirinae, in the Coronaviridae family. Those viruses are a positive-sense and very long single-stranded RNA viruses. Infection- related to SARS CoV2 was named as a pandemic disease by the World Health Organization on Mars 4, 2020. Aim and Objective: The objective of this work is the identification of potential vaccine targets of SARS CoV2. We aim to provide the potential therapeutic target that can inhibit the spread of virus and identify miRNAs, and reminding proposals to improving the effectiveness of these vaccines. Methods: Several clinical trials have been stated to design the management process against this pathology and the most proposed drugs have been commercialized for other viral pathologies. Thus, no specific therapeutic protocol has been established. Results: Our result showed that the potential molecules may specific region in the viral ARN and exert an inhibitor activity against the viral transcription. Conclusion: We conclude throughout our results that several potential therapeutic targets can act at different stages of the viral life cycle by identifying siRNA interfering with molecules that may inhibit viral replication.

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Velasco, Manuel Reyes. "A Case Report on a Chemotherapy Treatment to a SARSCOV2 PCR Positive, Non-Hodgkins Lymphoma Filipino Patient." Blood 140, Supplement 1 (November 15, 2022): 11999–2000. http://dx.doi.org/10.1182/blood-2022-170968.

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Álvarez Piedra, Andrés Edmundo, Juan Pablo Holguín Carvajal, and Arianna Sofia Torres Ochoa. "Percepción de la comunidad de estudiantes de pregrado de la Universidad del Azuay frente a una vacuna para el SARS-CoV 2." Revista Médica del Hospital José Carrasco Arteaga 14, no. 2 (December 15, 2022): 118–16. http://dx.doi.org/10.14410/2022.14.2.ao.17.

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BACKGROUND: To date, there are no specific standardized treatments for SARS-COV2 infection hence, the importance of all the efforts focused during this pandemic on the development of vaccines against this infectious agent; however, public acceptance of a licensed vaccine has multiple challenges. The aim of this study was to determine the perception of the undergraduate students at Universidad del Azuay to opt for a vaccine against SARS-CoV2. METHODS: Descriptive, observational, cross-sectional study. An electronic survey was applied, between the months of January and February 2021, to a sample of 1 497 students enrolled in the 2020-2021 school year who agreed to participate. The survey contains 11 questions on sociodemographic data and characteristics of the participants and 6 questions on the perception of different aspects of the vaccine. The Chi-Square test was applied between the variables, with a confidence level of 95%. RESULTS: The acceptance of the participants for a free vaccine against SARS-CoV2 was 76.4%, this percentage of acceptance varies to 58.1% if the vaccine had a cost of 50 US dollars. Acceptance of a physician-recommended immunization process was 78%. 75.3% of the students believed that it is important to vaccinate people with comorbidities. 58% of students thought that the vaccines would be effective and 50.6% of those surveyed said that the vaccines would meet quality standards. CONCLUSION: Most of the participants would accept a vaccine against SARS-CoV2; acceptance increases if there is a recommendation from medical personnel and decreases if the vaccine has a cost. A statistically significant association was found between the acceptance of the vaccine and the following variables: sex, age, school, residence, income, type of work, social security affiliation, source of information on COVID-19, otherprevious vaccinations, previous infection with COVID-19.

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Walczak, Katarzyna, Anna Makuch-Kocka, and Justyna Ziemińska. "Molecular mechanisms of drugs recommended in COVID-19 treatment." Polish Journal of Public Health 130, no. 1 (January 1, 2020): 61–64. http://dx.doi.org/10.2478/pjph-2020-0014.

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Abstract The development of an effective treatment for COVID-19 is now one of the main tasks of scientists and doctors from all over the world. The rapidly spreading SARS-CoV2 virus infection is a serious health problem among the public. Similarity of SARSCoV2 to MERS-CoV and SARS-CoV may suggest the effectiveness of COVID-19 treatment with drugs used to fight infections of previously identified Coronaviridae viruses. On the basis of gained experience and new clinical trials, the Polish Society of Epidemiologists and Infectious Diseases Physicians has created guidelines for the treatment of COVID-19. The recommendations concern primary and supportive treatment at different stages of the disease. This article provides a brief review of the molecular mechanisms of drugs currently used in Poland for the treatment of COVID-19.

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Chusin Montesdeoca, Jonathan Marcos, María Andrea Mosquera Salazar, Jimmy Mauricio Barreiro Casanova, and Johanna Priscila Duque López. "Enfermedad de Kawasaki asociada a infección por Dengue: reporte de un caso." Revista Medicina e Investigación Clínica Guayaquil 2, no. 3 (November 18, 2021): 45–47. http://dx.doi.org/10.51597/rmicg.v2i3.77.

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El dengue es una virosis común en Latinoamérica, de la cual pueden derivar múltiples complicaciones, las más comunes asociadas a la disfunción endotelial propia de la fisiopatología de esta enfermedad. Sin embargo, es limitada la literatura sobre las complicaciones asociadas a vasculitis, como es el caso de la enfermedad de Kawasaki, de la cual aún se desconoce su causa, sospechándose en infecciones virales como gatillantes de la reacción hiperinmune y, de entre los cuales, la literatura reciente describe una asociación con el virus del SarsCov2, responsable de la actual pandemia. Se reporta un caso de enfermedad de Kawasaki asociada a infección por Dengue, que fue tratado en un hospital de la ciudad de Guayaquil – Ecuador, durante los meses en los que esta ciudad se encontraba severamente afectada por la pandemia de COVID-19.

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Serrano Medina, Juan David. "Estimación del número efectivo de reproducción para la pandemia causada por el Sars-Cov2 en Bogotá D.C." Boletín Epidemiológico Distrital - Bed 18, no. 12 (August 2, 2022): 4–47. http://dx.doi.org/10.56085/01238590.423.

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El número efectivo de reproducción (Rt) representa la velocidad del contagio para los diferentes virus que puedan afectar una población. En este documento se presenta la forma en la que se evaluó el Rt en Bogotá D.C., en el contexto de la pandemia por el virus SarsCov2, con el objetivo de hacer monitoreoconstante de la avanzada del virus y tomar decisiones que desaceleren a tiempo, en caso de ser necesario, el contagio. Luego de una corta introducción se presentan los métodos usados, así como la solución a un problema de rezago en la información. Los resultados se prestan en forma de gráf cas que evidencian la situación de la ciudad en el tiempo. Se discuten los resultados y se presentan conclusiones que marcan la importancia de monitorear este indicador.

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Sahoo, Jyotirmayee, and BR Abha Ayushree. "Eating Habit during Covid-19." International Journal of Agro Nutrifood Practices 1, no. 2 (November 12, 2021): 9–15. http://dx.doi.org/10.36647/ijanp/01.02.a002.

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A healthy diet is important for good health and nutrition. Optimal nutrition will improve well-being and may mitigate the danger and morbidity associated with coronavirus illness 2019 (COVID-19), caused by the severe acute metabolic process syndrome coronavirus combine of (SARS-CoV-2). This book chapter summarizes nutritional guidelines to support good eating habits during Covid-19. The majority of documents enthused the consumption of fruits, vegetables, and whole grain foods. 31% of the guidelines highlighted the importance of minerals and vitamins such as zinc and vitamin-C, A, and D to keep up a well-functioning immune system. There was no convincing proof that food or food packaging is expounded to the transmission of COVID-19, yet sensible hygiene practices for handling and making preparing foods were counselled. Keywords : SarsCoV2, COVID-19, eating behaviours

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Torti, Lorenza, Francesco Sorrentino, Laura Maffei, Paolo De Fabritiis, and Elisabetta Abruzzese. "Epidemiological surveillance of SARSCov2 in β-Thalassemia Patients in the last two years: reinfection rate, insights and future challenges." Mediterranean Journal of Hematology and Infectious Diseases 15, no. 1 (January 1, 2023): e2023007. http://dx.doi.org/10.4084/mjhid.2023.007.

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Background: Although the association between comorbidities and the severity of COVID-19 infection has been extensively discussed, data on COVID-19 and hemoglobinopathies are still limited. SARS-Cov2 reinfections with severe acute respiratory syndrome have been described in the general population, usually with a milder outcome compared to the primary infection. The aim of our study was to determine the rate of reinfection and clinical features in a population of β-thalassemia patients. Results: Following the first infection, patients showed an adequate humoral immune response, however, all four patients are considered immune impaired owing to chronic transfusional support coupled with iron chelating treatment and splenectomy in three of the four.

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Stewart, William H. "A global crash-course in teaching and learning online: A thematic review of empirical Emergency Remote Teaching (ERT) studies in higher education during Year 1 of COVID-19." Open Praxis 13, no. 1 (March 30, 2021): 89. http://dx.doi.org/10.5944/openpraxis.13.1.1177.

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The COVID-19 pandemic has impacted education in ways that academic institutions, scholars, administrators, educators, and students will strive to fully comprehend for years to come. The global spread of SARSCoV2 in early 2020 prompted social distancing as the primary countermeasure against contracting and spreading the novel coronavirus, which in turn led academic communities worldwide to suddenly transition to emergency remote teaching (ERT) in order to maintain educational continuity. This review of the literature synthesizes findings from 38 empirical studies set in higher education about ERT in 2020 from all over the world. A thematic analysis of findings produced four major themes: 1) diverse ERT experiences; 2) digital divide and vast educational/socio economic inequalities; 3) commonly-experienced ERT problems, issues, and challenges; and 4) frequently-made adjustments in response to ERT. Findings are indicative of the immediate aftermath of transitions to ERT, and open areas of research for long-term impacts of ERT are discussed.

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AL-Samydai, Ali, Maha N. Abu Hajleh, Amal Akour, Naeem Shalan, Nisrein Jaber, Lidia Kamal Al-Halaseh, and Muhammed Alzweiri. "Investigation into the prophylactic and therapeutic activity of coenzyme Q10 against COVID-19." Tropical Journal of Pharmaceutical Research 20, no. 11 (December 13, 2021): 2387–93. http://dx.doi.org/10.4314/tjpr.v20i11.22.

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Purpose: To evaluate the anti-SARS CoV-2 effect of Coenzyme Q 10, Ubiquinol-10, and idebenone, which have beneficial therapeutic applications against diverse virus types, using molecular docking approach.Methods: The potential activity of Coenzyme Q10, Ubiquinol-10, and Idebenone against viral infections was explored through the collection of data from relevant literature, and by modelling these compounds virtually, using in silico investigation methods.Results: Coenzyme Q10 and ubiquinol-10 showed significant docking performance. They interacted with numerous amino acid residues of the main protease of SARS-CoV-2 ACE2 (7C8J), Alpha thrombin (1AE8), TYRO (4TS1) protein targets sides, SARS-coronavirus Orf7a accessory protein (1XAK), TNF (1RJ8), and Cytokine/receptor (1I1R).Conclusion: The findings of our study showed promising inhibitory activities of the selected compounds against the main proteases of SARS-CoV-2. Consequently, these compounds have theoretical effects on inhibiting the viral entry, reproduction, and ultimately the prevention and/or treatment of the SARSCoV2 infection.

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Dita, Willia Cahaya, Dedy Abdullah, and Dwita Deslianti. "Automatic hand washing faucet design using voice reminder for Covid-19 prevention protocol." Borobudur Informatics Review 1, no. 2 (December 6, 2021): 99–108. http://dx.doi.org/10.31603/binr.6145.

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Covid19 (2019 coronavirus disease) adalah penyakit baru yang disebabkan oleh virus dari keluarga coronavirus, yaitu SARSCoV2, juga dikenal sebagai virus Corona. Sampai saat ini belum ada alat mencuci tangan yang memberikan notifikasi berupa suara pengingat untuk mencuci tangan secara terus-menerus dan berhenti setelah digunakan, padahal cuci tangan ini sangat penting untuk mematikan virus Covid-19. Hasil dari alat kran cuci tangan otomatis dengan pengingat berupa suara yang dirancang terdiri dari dua bagian yang pertama yaitu sensor ultrasonik mendeteksi adanya orang dengan kondisi yang telah ditentukan yaitu jarak diatas 25 cm dan dibawah 50 cm maka peringatan berupa suara untuk mencuci tangan akan hidup dan peringatan akan mati apabila ada orang yang mencuci tangan dengan jarak dibawah 25 cm maka kran air hidup dan peringatan suara mati. Kemudian bagian kedua yaitu sensor ultasonik mendeteksi level air dengan jarak yang ditentukan yaitu 26 cm maka peringatan berupa suara air mulai habis akan hidup.

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Gwóźdź, Tomasz. "RELIEFS IN THE REPAYMENT OF PROPERTY TAX LIABILITIES, TAKING INTO ACCOUNT SPECIFIC LEGAL SOLUTIONS IN CONNECTION WITH THE SARSCOV2 PANDEMIC." Roczniki Administracji i Prawa 1, no. XXI (March 30, 2021): 185–98. http://dx.doi.org/10.5604/01.3001.0015.2534.

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The subject of the article is tax relief in the payment of property tax liabilities. Both solutions resulting directly from the Tax Code and those introduced in connection with the SARS CoV-2 epidemic and its economic consequences were taken into account. The types of discounts were discussed, as well as the conditions that must be met in order to apply them. It was indicated how to understand the important interest of the taxpayer and the public interest, referring to the decisions of administrative courts and the views of the doctrine. Special solutions for entrepreneurs in this regard were also analyzed separately. The most important rules of procedure for granting the requested tax reliefs are also presented. The article ends with conclusions and an attempt to evaluate the current legal regulations.

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Nilakesuma, Nur Fadjri. "BUMIL SIGAP DI ERA PANDEMI COVID 19." Jurnal Pengabdian Barelang 3, no. 01 (January 28, 2021): 51. http://dx.doi.org/10.33884/jpb.v3i01.2724.

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Virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARSCOV2) atau yang lebih dikenal dengan nama Coronavirus disease 2019 (COVID-19) adalah penyakit yang sedang mewabah hampir di seluruh dunia saat ini. Infeksi COVID-19 dapat menimbulkan gejala ringan, sedang atau berat. Masyarakat harus masif untuk edukasi dan diikuti dengan sanksi untuk menurunkan PR Covid 19. Edukasi ini bisa dilakukan oleh para professional (IDI, IBI, PPNI, Kesmas,MUI, DMI dan lain – lain). Tanpa edukasi yang baik, maka PR akan terus meningkat. Tujuan kegiatan pengabdian adalah memberikan edukasi tentang pedoman ibu hamil di era pandemic covid 19 dan tanda bahaya kehamilan kepada ibu hamil di PMB bidan Silvia Novita Sari Amd.,Keb tanggal 30 September – 1 Oktober 2020. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan Ibu hamil tentang pelayanan maternal dan neonatal di era pandemic covid 19 dan tanda – tanda bahaya dalam kehamilan. Diperlukan edukasi secara holistik terhadap seluruh ibu hamil yang tidak hadir pada saat kegiatan pengabdian sehingga ibu hamil di wilayah PMB tersebut meningkatkan kewaspadaan dalam penyebaran virus covid 19

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Mamun, SM AA, Zafor Iqbal, Arif Mahmood, and Sania Ahsan. "Post-COVID19 Lung Fibrosis: An Worrying Experience of COVID19 Survivors." Bangladesh Journal of Medicine 33, no. 1 (December 6, 2021): 114–19. http://dx.doi.org/10.3329/bjm.v33i1.56801.

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Patients recovering from confirmed COVID19 particularly moderate to severe disease, those treated in HDU / ICU support with high flow nasal cannula & Mechanical ventilation ,experienced different symptoms ranging from tiredness, fatigue to severe exertional dyspnea. High resolution CT scan of Chest of these such patients showed persistent radiological abnormalities simulating progressive fibrotic lung disease. Lung function including CO transfer factor revealed moderate to severe reduction. In case of patients recovered from moderate to severe COVID19 pneumonia, lung fibrosis is a big problem and it is one of the most worrying long-term complications. Lung fibrosis was documented in previous Severe Acute Respiratory Syndrome & Middle east Respiratory Syndrome pathology, and current observational studies suggests that pulmonary fibrosis could also complicate infection by SARSCOV2. The objective of our study was to set up a criteria of patients who are at risk to develop such serious complication, thus giving a chance for early detection of post-COVID19 lung fibrosis and thus preventing such disabling complication by proper andearly intervention . Bangladesh J Medicine July 2022; 33(1) : 114-119

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Dumbraveanu, Ion, Andrei Bradu, Iurii Arian, Mihaela Ivanov, Felicia Bulai, and Emil Ceban. "Impact of sars-cov-2 virus on male urinary and reproductive system." Akademos, no. 3(62) (January 2022): 41–48. http://dx.doi.org/10.52673/18570461.21.3-62.05.

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SARS-CoV-2 virus affects all organs and systems of the human body, including urinary and reproductive. Covid-19 disease has symptoms, clinical evolution and unknown complications till our days. Based on urology-specific systematic literature review, the authors describe the epidemiology and mechanisms of male urinary and reproductive system damaged by SARS-CoV-2 virus. The pathogenesis of renal impairment in Covid-19 is multifactorial with direct action of the virus on the nephron, but especially due to factors generated by inflammatory process, intravascular coagulation, hypovolemia, cytokine storm or toxic drug action. The presence of kidney disease until infection with SARSCoV2 virus can be interpreted as a risk factor for the evolution of the disease. Covid-19 disease also has an impact on male sexual-reproductive function, due to erectile dysfunction, decreased sperm motility or hormonal influences. At the moment, there is no evidence about presence of the specific effective drug for the treatment of Covid-19, the only medical solution to avoid side effects of the disease, is and remains vaccination.

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Journal articles on the topic 'SARSCoV2'

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