Relevant bibliographies by topics / SARS-CoV-2 (SARS2)

Academic literature on the topic 'SARS-CoV-2 (SARS2)'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "SARS-CoV-2 (SARS2)"

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Harrington, Whitney E., Winnie Yeung, Ingrid A. Beck, Fred D. Mast, John Houck, Sheila Styrchak, Leslie R. Miller, et al. "Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study." PLOS ONE 17, no. 9 (September 26, 2022): e0274078. http://dx.doi.org/10.1371/journal.pone.0274078.

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Background Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear. Methods To identify SARS-CoV-2 infections 553 seronegative individuals were prospectively followed for 52 weeks. From 4/2020-7/2021, participants submitted weekly self-collected nasal swabs for rtPCR and completed symptom and exposure surveys. Results Incident SARS2-CoV-2 infections were identified in 9/553 (1.6%) participants. Comparisons of SARS2-CoV-2(+) to SARS2-CoV-2(-) participants revealed significantly more close contacts outside the household (median: 5 versus 3; p = 0.005). The incidence of infection was higher among unvaccinated/partially vaccinated than among fully vaccinated participants (9/7,679 versus 0/6,845 person-weeks; p = 0.004). At notification of positive test result, eight cases were symptomatic and one pre-symptomatic. Conclusions These data suggest that weekly SARS2-CoV2 surveillance by rtPCR did not efficiently detect pre-symptomatic infections in unvaccinated participants.
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Warren, René L., and Inanc Birol. "Interactive SARS-CoV-2 mutation timemaps." F1000Research 10 (February 3, 2021): 68. http://dx.doi.org/10.12688/f1000research.50857.1.

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As the year 2020 came to a close, several new strains have been reported of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that has afflicted us all this past year. However, it is difficult to comprehend the scale, in sequence space, geographical location and time, at which SARS-CoV-2 mutates and evolves in its human hosts. To get an appreciation for the rapid evolution of the coronavirus, we built interactive scalable vector graphics maps that show daily nucleotide variations in genomes from the six most populated continents compared to that of the initial, ground-zero SARS-CoV-2 isolate sequenced at the beginning of the year. Availability: The tool used to perform the reported mutation analysis results, ntEdit, is available from GitHub. Genome mutation reports are available for download from BCGSC. Mutation time maps are available from https://bcgsc.github.io/SARS2/.
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Warren, René L., and Inanc Birol. "Interactive SARS-CoV-2 mutation timemaps." F1000Research 10 (June 3, 2021): 68. http://dx.doi.org/10.12688/f1000research.50857.2.

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As the year 2020 came to a close, several new strains have been reported of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that has afflicted us all this past year. However, it is difficult to comprehend the scale, in sequence space, geographical location and time, at which SARS-CoV-2 mutates and evolves in its human hosts. To get an appreciation for the rapid evolution of the coronavirus, we built interactive scalable vector graphics maps that show daily nucleotide variations in genomes from the six most populated continents compared to that of the initial, ground-zero SARS-CoV-2 isolate sequenced at the beginning of the pandemic. Availability: The tool used to perform the reported mutation analysis results, ntEdit, is available from GitHub. Genome mutation reports are available for download from BCGSC. Mutation time maps are available from https://bcgsc.github.io/SARS2/.
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O’Donnell, Kyle L., Tylisha Gourdine, Paige Fletcher, Kyle Shifflett, Wakako Furuyama, Chad S. Clancy, and Andrea Marzi. "VSV-Based Vaccines Reduce Virus Shedding and Viral Load in Hamsters Infected with SARS-CoV-2 Variants of Concern." Vaccines 10, no. 3 (March 12, 2022): 435. http://dx.doi.org/10.3390/vaccines10030435.

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The continued progression of the COVID-19 pandemic can partly be attributed to the ability of SARS-CoV-2 to mutate and introduce new viral variants. Some of these variants with the potential to spread quickly and conquer the globe are termed variants of concern (VOC). The existing vaccines implemented on a global scale are based on the ancestral strain, which has resulted in increased numbers of breakthrough infections as these VOC have emerged. It is imperative to show protection against VOC infection with newly developed vaccines. Previously, we evaluated two vesicular stomatitis virus (VSV)-based vaccines expressing the SARS-CoV-2 spike protein alone (VSV-SARS2) or in combination with the Ebola virus glycoprotein (VSV-SARS2-EBOV) and demonstrated their fast-acting potential. Here, we prolonged the time to challenge; we vaccinated hamsters intranasally (IN) or intramuscularly 28 days prior to infection with three SARS-CoV-2 VOC—the Alpha, Beta, and Delta variants. IN vaccination with either the VSV-SARS2 or VSV-SARS2-EBOV resulted in the highest protective efficacy as demonstrated by decreased virus shedding and lung viral load of vaccinated hamsters. Histopathologic analysis of the lungs revealed the least amount of lung damage in the IN-vaccinated animals regardless of the challenge virus. This data demonstrates the ability of a VSV-based vaccine to not only protect from disease caused by SARS-CoV-2 VOC but also reduce viral shedding.
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Kibler, Karen V., Mateusz Szczerba, Douglas Lake, Alexa J. Roeder, Masmudur Rahman, Brenda G. Hogue, Lok-Yin Roy Roy Wong, Stanley Perlman, Yize Li, and Bertram L. Jacobs. "Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501YMA30 Strain of SARS-CoV-2." Vaccines 10, no. 8 (July 23, 2022): 1172. http://dx.doi.org/10.3390/vaccines10081172.

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The Omicron SARS-CoV-2 variant has been designated as a variant of concern because its spike protein is heavily mutated. In particular, the Omicron spike is mutated at five positions (K417, N440, E484, Q493, and N501) that have been associated with escape from neutralizing antibodies induced by either infection with or immunization against the early Washington strain of SARS-CoV-2. The mouse-adapted strain of SARS-CoV-2, SARS2-N501YMA30, contains a spike that is also heavily mutated, with mutations at four of the five positions in the Omicron spike associated with neutralizing antibody escape (K417, E484, Q493, and N501). In this manuscript, we show that intranasal immunization with a pre-fusion stabilized Washington strain spike, expressed from a highly attenuated, replication-competent vaccinia virus construct, NYVAC-KC, fully protected mice against symptoms and death from SARS2-N501YMA30. Similarly, immunization by scarification on the skin fully protected against death, but not from mild disease. This data demonstrates that the Washington strain spike, when expressed from a highly attenuated, replication-competent poxvirus—administered without parenteral injection—can fully protect against the heavily mutated mouse-adapted SARS2-N501YMA30.
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Liu, Ying, Lu Li, Khalid A. Timani, and Johnny J. He. "A Unique Robust Dual-Promoter-Driven and Dual-Reporter-Expressing SARS-CoV-2 Replicon: Construction and Characterization." Viruses 14, no. 5 (May 5, 2022): 974. http://dx.doi.org/10.3390/v14050974.

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The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, SARS2) remains a great global health threat and demands identification of more effective and SARS2-targeted antiviral drugs, even with successful development of anti-SARS2 vaccines. Viral replicons have proven to be a rapid, safe, and readily scalable platform for high-throughput screening, identification, and evaluation of antiviral drugs against positive-stranded RNA viruses. In the study, we report a unique robust HIV long terminal repeat (LTR)/T7 dual-promoter-driven and dual-reporter firefly luciferase (fLuc) and green fluorescent protein (GFP)-expressing SARS2 replicon. The genomic organization of the replicon was designed with quite a few features that were to ensure the replication fidelity of the replicon, to maximize the expression of the full-length replicon, and to offer the monitoring flexibility of the replicon replication. We showed the success of the construction of the replicon and expression of reporter genes fLuc and GFP and SARS structural N from the replicon DNA or the RNA that was in vitro transcribed from the replicon DNA. We also showed detection of the negative-stranded genomic RNA (gRNA) and subgenomic RNA (sgRNA) intermediates, a hallmark of replication of positive-stranded RNA viruses from the replicon. Lastly, we showed that expression of the reporter genes, N gene, gRNA, and sgRNA from the replicon was sensitive to inhibition by Remdesivir. Taken together, our results support use of the replicon for identification of anti-SARS2 drugs and development of new anti-SARS strategies targeted at the step of virus replication.
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Royal, Joshua M., Carrie A. Simpson, Alison A. McCormick, Amanda Phillips, Steve Hume, Josh Morton, John Shepherd, et al. "Development of a SARS-CoV-2 Vaccine Candidate Using Plant-Based Manufacturing and a Tobacco Mosaic Virus-like Nano-Particle." Vaccines 9, no. 11 (November 17, 2021): 1347. http://dx.doi.org/10.3390/vaccines9111347.

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Stable, effective, easy-to-manufacture vaccines are critical to stopping the COVID-19 pandemic resulting from the coronavirus SARS-CoV-2. We constructed a vaccine candidate CoV-RBD121-NP, which is comprised of the SARS-CoV-2 receptor-binding domain (RBD) of the spike glycoprotein (S) fused to a human IgG1 Fc domain (CoV-RBD121) and conjugated to a modified tobacco mosaic virus (TMV) nanoparticle. In vitro, CoV-RBD121 bound to the host virus receptor ACE2 and to the monoclonal antibody CR3022, a neutralizing antibody that blocks S binding to ACE2. The CoV-RBD121-NP vaccine candidate retained key SARS-CoV-2 spike protein epitopes, had consistent manufacturing release properties of safety, identity, and strength, and displayed stable potency when stored for 12 months at 2–8 °C or 22–28 °C. Immunogenicity studies revealed strong antibody responses in C57BL/6 mice with non-adjuvanted or adjuvanted (7909 CpG) formulations. The non-adjuvanted vaccine induced a balanced Th1/Th2 response and antibodies that recognized both the S1 domain and full S protein from SARS2-CoV-2, whereas the adjuvanted vaccine induced a Th1-biased response. Both adjuvanted and non-adjuvanted vaccines induced virus neutralizing titers as measured by three different assays. Collectively, these data showed the production of a stable candidate vaccine for COVID-19 through the association of the SARS-CoV-2 RBD with the TMV-like nanoparticle.
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Rodrigues, Rui, and Sofia Costa de Oliveira. "The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review." Microorganisms 9, no. 8 (August 9, 2021): 1692. http://dx.doi.org/10.3390/microorganisms9081692.

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Angiotensin-Converting Enzyme 2 (ACE2) has been proved to be the main host cell receptor for the binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the COVID-19 pandemic. The SARS-CoV-2 spike (S) protein binds to ACE2 to initiate the process of replication. This enzyme is widely present in human organ tissues, such as the heart and lung. The pathophysiology of ACE2 in SARS-CoV-2 infection is complex and may be associated with several factors and conditions that are more severe in COVID-19 patients, such as age, male gender, and comorbidities, namely, cardiovascular diseases, chronic respiratory diseases, obesity, and diabetes. Here we present a comprehensive review that aims to correlate the levels of expression of the ACE2 in patients with comorbidities and with a poor outcome in COVID-19 disease. Significantly higher levels of expression of ACE2 were observed in myocardial and lung tissues in heart failure and COPD patients, respectively. An age-dependent increase in SARS2-CoV-2 receptors in the respiratory epithelium may be also responsible for the increased severity of COVID-19 lung disease in elderly people. Although the role of ACE2 is highlighted regarding the damage that can arise upon the SARS-CoV-2 invasion, there was no association observed between renin-angiotensin-aldosterone system (RAAS) inhibitors and the severity of COVID-19.
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Seibert, Brittany, C. Joaquín Cáceres, Silvia Carnaccini, Stivalis Cardenas-Garcia, L. Claire Gay, Lucia Ortiz, Ginger Geiger, Daniela S. Rajao, Elizabeth Ottesen, and Daniel R. Perez. "Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2." PLOS Pathogens 18, no. 10 (October 24, 2022): e1010734. http://dx.doi.org/10.1371/journal.ppat.1010734.

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The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS2) affected the geriatric population. Among research models, Golden Syrian hamsters (GSH) are one of the most representative to study SARS2 pathogenesis and host responses. However, animal studies that recapitulate the effects of SARS2 in the human geriatric population are lacking. To address this gap, we inoculated 14 months old GSH with a prototypic ancestral strain of SARS2 and studied the effects on virus pathogenesis, virus shedding, and respiratory and gastrointestinal microbiome changes. SARS2 infection led to high vRNA loads in the nasal turbinates (NT), lungs, and trachea as well as higher pulmonary lesions scores later in infection. Dysbiosis throughout SARS2 disease progression was observed in the pulmonary microbial dynamics with the enrichment of opportunistic pathogens (Haemophilus, Fusobacterium, Streptococcus, Campylobacter, and Johnsonella) and microbes associated with inflammation (Prevotella). Changes in the gut microbial community also reflected an increase in multiple genera previously associated with intestinal inflammation and disease (Helicobacter, Mucispirillum, Streptococcus, unclassified Erysipelotrichaceae, and Spirochaetaceae). Influenza A virus (FLUAV) pre-exposure resulted in slightly more pronounced pathology in the NT and lungs early on (3 dpc), and more notable changes in lungs compared to the gut microbiome dynamics. Similarities among aged GSH and the microbiome in critically ill COVID-19 patients, particularly in the lower respiratory tract, suggest that GSHs are a representative model to investigate microbial changes during SARS2 infection. The relationship between the residential microbiome and other confounding factors, such as SARS2 infection, in a widely used animal model, contributes to a better understanding of the complexities associated with the host responses during viral infections.
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Wang, Jiong, Bridget E. Young, Dongmei Li, Antti Seppo, Qian Zhou, Alexander Wiltse, Anna Nowak-Wegrzyn, et al. "Broad Cross-Reactive IgA and IgG against Human Coronaviruses in Milk Induced by COVID-19 Vaccination and Infection." Vaccines 10, no. 6 (June 20, 2022): 980. http://dx.doi.org/10.3390/vaccines10060980.

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It is currently unclear if SARS-CoV-2 infection or mRNA vaccination can also induce IgG and IgA against common human coronaviruses (HCoVs) in lactating parents. Here we prospectively analyzed human milk (HM) and blood samples from lactating parents to measure the temporal patterns of anti-SARS-CoV-2 specific and anti-HCoV cross-reactive IgA and IgG responses. Two cohorts were analyzed: a vaccination cohort (n = 30) who received mRNA-based vaccines for COVID-19 (mRNA-1273 or BNT162b2), and an infection cohort (n = 45) with COVID-19 disease. Longitudinal HM and fingerstick blood samples were collected pre- and post-vaccination or, for infected subjects, at 5 time-points 14–28 days after confirmed diagnosis. The anti-spike(S) and anti-nucleocapsid(N) IgA and IgG antibody levels against SARS-CoV-2 and HCoVs were measured by multiplex immunoassay (mPlex-CoV). We found that vaccination significantly increased the anti-S IgA and IgG levels in HM. In contrast, while IgG levels increased after a second vaccine dose, blood and HM IgA started to decrease. Moreover, HM and blood anti-S IgG levels were significantly correlated, but anti-S IgA levels were not. SARS2 acute infection elicited anti-S IgG and IgA that showed much higher correlations between HM and blood compared to vaccination. Vaccination and infection were able to significantly increase the broadly cross-reactive IgG recognizing HCoVs in HM and blood than the IgA antibodies in HM and blood. In addition, the broader cross-reactivity of IgG in HM versus blood indicates that COVID-19 vaccination and infection might provide passive immunity through HM for the breastfed infants not only against SARS-CoV-2 but also against common cold coronaviruses.
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Dissertations / Theses on the topic "SARS-CoV-2 (SARS2)"

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Daff, Kaitlyn M. "Nutritional Implications in SARS-CoV-2." Youngstown State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1596622611336371.

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Dafalla, Israa Yahia Al Hag Ibrahim. "Improving SARS-CoV-2 analyses from wastewater." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20237.

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Wastewater-based epidemiology (WBE) analyzes wastewater for the presence of biological and chemical substances to make public health conclusions. COVID-19 disease is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that infected individuals shed also in their feces, making WBE an alternative way to track SARS-CoV-2 in populations. There are many limitations to the detection and quantification of SARS-CoV-2 from wastewater, such as sample quality, storage conditions or viral concentration. This thesis aims to determine the extent of these limitations and the factors that contribute to them. Other viruses can help the measurements for example Bovine coronavirus (BCoV) can be spiked as a process surrogate, while Pepper mild mottle virus (PMMoV), a fecal biomarker is used to estimate the prevalence of SARS-CoV-2 infection. This study involved two distinct wastewater samples. For method comparison both samples were processed with two methods: virus concentration by electronegative (EN) filtration or direct RNA extraction method. From the RNA extracts RT-qPCR assays were performed to identify and quantify SARS-CoV-2, BCoV, and PMMoV. Based on the obtained cycle threshold (Ct) values, viral gene copy numbers and virus concentration of the original wastewater samples were calculated. Statistical tests were conducted to assess suggested hypothesizes and variations within the data. Results revealed differences in viral contents due to different sample qualities and as a result of freezing and thawing. Furthermore, different sample processing methods led to differences in quantification. In conclusion, improving analysis of SARS-CoV-2 in wastewater using methodologies with better detection efficiency leads to more reliable results.
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Vareschi, Rodolfo Dimitrius. "Cloud computing adoption during SARS-COV-2 pamdemic." Master's thesis, Instituto Superior de Economia e Gestão, 2021. http://hdl.handle.net/10400.5/21746.

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Mestrado em Gestão de Sistemas de Informação
Due to the rapid global spread of the pandemic caused by the new coronavirus, companies and institutions were forced to take precautionary measures to reduce the risk of contagion, such as asking employees to work remotely from their homes. In this scenario, cloud computing technology has proven to be a great ally of companies to overcome the crisis caused by the pandemic.The adoption of Cloud Computing technology has accelerated in recent years and, according to a forecast made by the International Data Corporation (IDC), investment in cloud services will exceed US $ 1.0 trillion in 2024, which represents a rate of annual growth of 15.7% (Villars et al., 2020).In an attempt to help organizations plan their strategies for adopting cloud computing, the present study intends to contribute to the existing literature on the subject, aiming to identify the main factors that influence the adoption of such technology during the Covid-19 pandemic crises.For this purpose, 18 factors identified during the literature review and were presented to 11 experts in the field of cloud computing technology, in order to seek a consensus regarding the order of importance of these factors.Through the Delphi method, divided into two phases and with two rounds, a list was obtained, ordered according to the degree of importance of the main factors that influence the adoption of cloud computing. After analyzing the data, the results obtained show that the six most important factors are: (1) Adoption, Migration and Acquisition Cost; (2) Availability and Accessibility; (3) Scalability; (4) Cost of Data Confidentiality and Availability Loss; (5) Security and (6) Customization.
Devido à rápida disseminação global da pandemia causada pelo novo coronavírus, empresas e instituições foram forçadas a tomar medidas de precaução para reduzir o risco de contágio, como pedir aos funcionários que trabalhassem remotamente das suas casas. Nesse cenário, a tecnologia de computação em nuvem tem se mostrado uma grande aliada das empresas para superar a crise provocada pela pandemia.A adoção de Computação em Nuvem tem se acelerado nos últimos anos e, segundo previsão da International Data Corporation (IDC), os investimentos em serviços em nuvem ultrapassarão US $ 1,0 milhão de bilhões em 2024, o que representa uma taxa de crescimento anual de 15,7% (Villars et al., 2020).Na tentativa de auxiliar as organizações no planeamento das suas estratégias de adoção da computação em nuvem, o presente estudo pretende contribuir com a literatura existente sobre o assunto, e tem como objetivo de identificar os principais fatores que influenciam a adoção dessa tecnologia durante a crise pandêmicas de Covid-19.Nesse sentido, 18 fatores identificados durante a revisão da literatura foram apresentados a 11 especialistas na área de tecnologia de computação em nuvem, a fim de encontrar um consenso quanto à ordem de importância desses fatores.Através do método Delphi, dividido em duas fases e com duas rondas, foi obtida uma lista ordenada de acordo com o grau de importância dos principais fatores que influenciam a adoção da computação em nuvem. Após a análise dos dados, os resultados obtidos mostram que os seis fatores mais importantes são: (1) Custo de Adoção, Migração e Aquisição; (2) Disponibilidade e acessibilidade; (3) Escalabilidade; (4) Custo de perda de confidencialidade e disponibilidade de dados; (5) Segurança e (6) Personalização.
info:eu-repo/semantics/publishedVersion
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Колюбакіна, Л. В., О. В. Власова, and Н. М. Крецу. "Kлініко-параклінічні особливості SARS-Cov-2 у новонароджених." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18391.

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Elfström, Mia. "Synthesis of SARS-CoV-2 Main Protease Inhibitors." Thesis, Uppsala universitet, Läkemedelsdesign och läkemedelsutveckling, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449953.

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Coronaviruses have been responsible for several global disease outbreaks over the last 20 years, including the “Severe Acute Respiratory Syndrome” in 2002/2003, the “Middle East Respiratory Syndrome” in 2012, and the “Coronavirus Disease of 2019 (COVID19)”. These viruses are highly contagious and can cause multiple medical disorders upon contraction, such as common cold or lower respiratory infections. SARS-CoV-2, the newly emerged coronavirus variant of 2019, has been confirmed as the cause of the ongoing COVID19 pandemic, which infected over 167 million people worldwide and, by the end of May 2021, has a death toll of over 3 million people. Even though several SARS-CoV-2 vaccines have made it to the market, no proven options have yet been discovered for treating COVID19 infections. The aim of this project is, therefore, to improve the potency of two active SARS-CoV-2 main protease (Mpro) inhibitors (ML188 and X77) by performing a structure-activity-relationship study where two specific sites of the inhibitors are altered. The inhibition activity of these compounds is then tested on isolated SARS-CoV-2 Mpro. The four-component Ugi reaction was utilized to synthesize the ML188 and X77 analogs, which were purified by column chromatography before testing. During this project, six pure analogs were successfully synthesized and will be sent shortly for testing. Inhibitors with good activity against SARS-CoV-2 Mpro will be further tested for their antiviral activity in cell-based infection assays. The results obtained from this study will later be used to perform a second structure-activity-relationship study to further improve the potency of the two inhibitors by developing a 2nd generation library.
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Bălan, Mirela. "Integrative bioinformatic analysis of SARs-CoV-2 data." Thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450821.

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Phan, Alexandra. "Identification of MMP-9 as a Driving Factor in SARS-CoV-2 Entry." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42771.

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Since its emergence in December 2019, SARS-CoV-2 has infected over 200 million people globally. SARS-CoV-2 spike (S) decorates the viral envelope and is responsible for facilitating viral entry into the host cell. To mediate membrane fusion, S must be proteolytically cleaved. For the closely related SARS-CoV S, cleavage at the host cell surface must be facilitated by the serine protease TMPRSS2. We demonstrated that SARS-CoV-2 S can facilitate fusion independent of TMPRSS2 and sought to identify other proteases capable of driving SARS-CoV-2 S-mediated fusion. We show that the ADAMs and MMP inhibitor GI 254023X is capable of substantially reducing SARS-CoV-2 S-mediated syncytium formation. Additionally, we identified MMP-9, a protein target of GI 254023X, as a host protease capable of enhancing SARS-CoV-2 lentivirus entry in HEK293T-ACE2 cells. These results implicate ADAM and MMP proteases, in particular MMP-9, as potential antiviral drug targets against COVID-19 pathogenesis.
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Bui, Xuan Klaudia. "Biosensori FET per il rilevamento del SARS-CoV-2." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020.

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Nel 2020 la presenza del SARS-CoV-2 ha indotto alla produzione e miglioramento dei metodi per la rilevazione del virus. Negli ospedali di Wuhan vari campionatori d'aria sono stati utilizzati per verificare la presenza e la diffusione del virus. Il campione così raccolto viene analizzato tramite la reazione a catena della polimerasi (PCR). Lo svantaggio principale di questa reazione è il tempo richiesto per la diagnosi che è di tre ore. Per questo motivo sono stati effettuati vari studi di ricerca per trovare un metodo più rapido ma sempre efficace. Quindi vengono proposte le ultime scoperte convalidate per la determinazione del SARS-CoV-2. In particolare, i candidati migliori vengono rappresentati dai biosensori, dispositivi veloci e altamente sensibili che usano i biorecettori per creare il legame con la cellula bersaglio. Il documento presenta una dettagliata analisi del funzionamento del transistor ad effetto campo rivestito di un film di grafene su cui vengono posizionati gli anticorpi del virus. Come mostrato nell'elaborato, questo è un ottimo dispositivo per un rapido rilevamento del virus in quanto in tempo reale fornisce l'esito, positivo o negativo, dei tamponi nasofaringei.
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Flygare, Agnes. "The synthesis of main protease inhibitorsagainst SARS-CoV-2." Thesis, Uppsala universitet, Preparativ läkemedelskemi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448451.

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Pisil, Yalcin. "The Study on Neutralization of Human Immunodeficiency Virus and SARS CoV-2 - Neutralization Resistance of SHIV and Neutralization Assay for SARS CoV-2 -." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/264673.

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京都大学
新制・課程博士
博士(人間・環境学)
甲第23392号
人博第1005号
新制||人||237(附属図書館)
京都大学大学院人間・環境学研究科相関環境学専攻
(主査)准教授 三浦 智行, 教授 川本 卓男, 准教授 西川 完途
学位規則第4条第1項該当
Doctor of Human and Environmental Studies
Kyoto University
DFAM
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Books on the topic "SARS-CoV-2 (SARS2)"

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Legach, Fr archpriest Evgeny I., and Konstantin S. Sharov, eds. SARS-CoV-2 and Coronacrisis. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2605-0.

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Goswami, Srijan, and Chiranjeeb Dey. COVID-19 and SARS-CoV-2. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003178514.

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Shelton-Davenport, Marilee, Julie Pavlin, Jennifer Saunders, and Amanda Staudt, eds. Airborne Transmission of SARS-CoV-2. Washington, D.C.: National Academies Press, 2020. http://dx.doi.org/10.17226/25958.

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Focosi, Daniele. SARS-CoV-2 Spike Protein Convergent Evolution. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-87324-0.

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Mueller, Siguna. Challenges and Opportunities of mRNA Vaccines Against SARS-CoV-2. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-18903-6.

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Prabha, S., P. Karthikeyan, K. Kamalanand, and N. Selvaganesan. Computational Modelling and Imaging for SARS-CoV-2 and COVID-19. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9781003142584.

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Berezina, Natal'ya, Mihail Cherkashin, and Nikita Berezin. Rational use of personal protective equipment in medical organizations in an unfavorable epidemiological situation ... ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1215689.

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The training manual discusses the organization of the use of personal protective equipment in the context of a new coronavirus infection (SARS-CoV-2) pandemic. It is intended for health care organizers, doctors of all specialties, and other medical professionals who provide care to patients with suspected or confirmed coronavirus infection.
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Berezina, Natal'ya, Mihail Cherkashin, Vladimir Kuplevackiy, Dar'ya Kuplevackaya, Tat'yana Rakova, Aleksey Nikolaev, Artem Fedorov, and Anna Lavrent'eva. Organization of the work of the outpatient computer tomography center to provide emergency care to patients with suspected new coronavirus infection. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1222384.

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The training manual discusses the organization of the outpatient computed tomography center, created to provide emergency care to patients with suspected new coronavirus infection (SARS-CoV-2). It is intended for health care organizers, radiologists, X-ray technicians, and other medical professionals who provide care to patients with suspected or laboratory-confirmed COVID-19 infection.
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Pennella, Valentino. SARS-CoV-2. Independently Published, 2020.

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Pennella, Valentino. SARS-CoV-2. Independently Published, 2020.

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Book chapters on the topic "SARS-CoV-2 (SARS2)"

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Focosi, Daniele. "SARS-CoV-2 Variants." In SpringerBriefs in Microbiology, 55–71. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-87324-0_6.

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Nowak-Far, Artur. "SARS-CoV-2 pandemic." In Contemporary States and the Pandemic, 69–87. London: Routledge India, 2022. http://dx.doi.org/10.4324/9781003353805-5.

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Yadav, Tushar, and Shailendra K. Saxena. "Transmission Cycle of SARS-CoV and SARS-CoV-2." In Medical Virology: From Pathogenesis to Disease Control, 33–42. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-4814-7_4.

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Sokolova, Svetlana N., and Anastasia A. Sokolova. "Radical Changes of Information Society During SARS-CoV-2 Pandemic and Structural Transformations of the Security Sphere: Experience of Republic of Belarus." In SARS-CoV-2 and Coronacrisis, 195–206. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2605-0_13.

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Sharov, Konstantin S. "SARS-CoV-2 in Acute Respiratory Infection Situation in Russia in Spring–Summer 2020." In SARS-CoV-2 and Coronacrisis, 55–66. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2605-0_4.

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Gerilovych, Fr priest Anton P., Borys T. Stegniy, Larysa V. Kovalenko, Yurii K. Dunaiev, Natalia S. Rodyna, Oksana V. Kinash, Vasiliy L. Arefiev, et al. "SARS-CoV-2 Zoonotic Potential: Current Knowledge and Hypotheses." In SARS-CoV-2 and Coronacrisis, 37–54. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2605-0_3.

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Legach, Fr archpriest Evgeny I., Galyna A. Bozhok, and Konstantin S. Sharov. "Using Experience in Previous Epidemics for Effective Containing SARS-CoV-2: Spanish Influenza 1918 and Beyond." In SARS-CoV-2 and Coronacrisis, 3–16. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2605-0_1.

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Sassin, Wolfgang. "Coronacrisis Reconstruction Programmes: Saving the “Global Economy”?" In SARS-CoV-2 and Coronacrisis, 221–48. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2605-0_15.

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Duna, Nataliia G. "Managing Economic, Cultural and Mental Crises Caused by COVID-19 Pandemic." In SARS-CoV-2 and Coronacrisis, 279–89. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2605-0_18.

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Moskovkin, Vladimir M., Tatyana V. Saprykina, and Igor V. Boichuk. "Phenomenon of Coronavirus Publication Race." In SARS-CoV-2 and Coronacrisis, 311–77. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2605-0_20.

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Conference papers on the topic "SARS-CoV-2 (SARS2)"

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Ay, Emrah, and Nizami Duran. "Resistance of SARS CoV-2 to Seawater." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.iii.2.

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SARS CoV-2, which is the cause of Covid-19 disease, has become the only and most important agenda of the world due to its mortality and morbidity that globally affects the whole world. The virus has profoundly affected life all over the world. The lifestyles of people have changed due to the virus. This study is planned to understand how important sea water is in SARS-CoV-2 transmission. The study aimed to determine whether there is a risk of sea water in SARS-CoV-2 transmission. The effectiveness of seawater on SARS CoV-2 viability has been investigated in different dilutions of seawater in different time periods. Experiments were carried out in three different titrations of SARS CoV-2 in Vero cell lines. Viral replication has been investigated by detecting morphological changes occurring in cells, cell viability, and the RT-PCR method. Seawater has been found to be highly potent inhibitory on SARS CoV-2 about time and dose. Especially within 300 seconds, seawater has been found to inhibit viral replication up to 1/32 dilution. These results show that viral transmission through seawater is quite difficult for people swimming in the sea during the pandemic. Seawater-mediated spread of SARS-CoV-2 is out of the question. However, these results should not be interpreted as the prophylactic activity of saline against viruses, which are obligate intracellular parasites.
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Lazarus, Theophilus. "SARS-CoV-2 infection and neuropsychological outcomes." In 2nd International Neuropsychological Summer School named after A. R. Luria “The World After the Pandemic: Challenges and Prospects for Neuroscience”. Ural University Press, 2020. http://dx.doi.org/10.15826/b978-5-7996-3073-7.10.

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The entire world is currently confronted with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS.CoV.2), a novel betacoronavirus causing the deadly pandemic of coronavirus disease 2019 (COVID.19). Since there is now increasing reports of neurological and cognitive problems, the impact of COVID.19 on neuropsychological functioning is unknown but is likely to leave residual problems.
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"APPLICATIONS OF SARS-COV-2 SEQUENCING DATA." In 14th International Conference on Computer Graphics, Visualization, Computer Vision and Image Processing. IADIS Press, 2020. http://dx.doi.org/10.33965/bigdaci2020_202011c034.

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Rivas Rodríguez, MD, RM Medina Comas, C. Redondo Galán, M. Ferris Villanueva, D. González Vaquero, and JF Rangel Mayoral. "4CPS-388 Telepharmacy during SARS-CoV-2." In 25th Anniversary EAHP Congress, Hospital Pharmacy 5.0 – the future of patient care, 23–28 March 2021. British Medical Journal Publishing Group, 2021. http://dx.doi.org/10.1136/ejhpharm-2021-eahpconf.220.

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Hatzipanagiotou, Maria, Miriam Fernandez, Rahel Deborah Huber, Olaf Ortmann, and Ute Germer. "Maternofetale Transmission bei Sars-CoV-2 Virusinfektion." In Interdisziplinärer Kongress | Ultraschall 2022. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1749557.

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Ferreira, Caíque Levir da Silva, Bárbara Guimarães Silqueira, Vanessa Giovanini Gasparoto, Ana Laura de Souza Campiello Talarico, and Ana Caroline Vendrame Cazeloto. "MANIFESTAÇÕES NEUROLÓGICAS CAUSADAS PELO SARS-COV-2." In III Congresso Online de Neurocirurgia e Neurologia. Congresse.me, 2022. http://dx.doi.org/10.54265/cnlc1334.

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Chen, Zhitong. "Cold Plasma for SARS-CoV-2 Inactivation." In 2021 IEEE International Conference on Plasma Science (ICOPS). IEEE, 2021. http://dx.doi.org/10.1109/icops36761.2021.9588571.

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Pavitt, Matthew, Sophie Krivinskas, Jo Congleton, and Sabrine Hippolyte. "SARS-CoV-2: Survival in COPD phenotypes." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.oa4195.

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Emi Aikawa, Nádia, Léonard de Vinci Kanda Kupa, Sandra Gofinet Pasoto, Ana Cristina de Medeiros Ribeiro, Emily Figueiredo Neves Yuki, Carla Gonçalves Schahin Saad, Tatiana Pedrosa, et al. "DYNAMICS OF INACTIVATED SARS-COV-2 VACCINE ANTIBODY RESPONSE IN SARS-COV-2-SEROPOSITIVE AUTOIMMUNE RHEUMATIC DISEASE PATIENTS." In SBR 2021 Congresso Brasileiro de Reumatologia. Sociedade Brasileira de Reumatologia, 2021. http://dx.doi.org/10.47660/cbr.2021.1905.

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Smatti, Maria K., Yasser Al-Sarraj, Omar Albagha, and Hadi M. Yassine. "Host Genetic Variants Potentially Associated with SARS-Cov-2: A Multi-Population Analysis." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0298.

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Background: Clinical outcomes of Coronavirus Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and interpopulation differences, possibly due to host genetics differences. Earlier studies identified single nucleotide polymorphisms (SNPs) associated with SARS-CoV-1 in Eastern Asian (EAS) populations. In this report, we aimed at exploring the frequency of a set of genetic polymorphisms that could affect SARS-CoV-2 susceptibility or severity, including those that were previously associated with SARS-CoV-1. Methods: We extracted the list of SNPs that could potentially modulate SARS-CoV-2 from the genome wide association studies (GWAS) on SARS-CoV-1 and other viruses. We also collected the expression data of these SNPs from the expression quantitative trait loci (eQTLs) databases. Sequences from Qatar Genome Programme (QGP, n=6,054) and 1000Genome project were used to calculate and compare allelic frequencies (AF). Results: A total of 74 SNPs, located in 10 genes: ICAM3, IFN-γ, CCL2, CCL5, AHSG, MBL, Furin, TMPRSS2, IL4, and CD209 promoter, were identified. Analysis of Qatari genomes revealed significantly lower AF of risk variants linked to SARS-CoV-1 severity (CCL2, MBL, CCL5, AHSG, and IL4) compared to that of 1000Genome and/or the EAS population (up to 25-fold change). Conversely, SNPs in TMPRSS2, IFN-γ, ICAM3, and Furin were more common among Qataris (average 2-fold change). Inter-population analysis showed that the distribution of risk alleles among Europeans differs substantially from Africans and EASs. Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations. Conclusion: Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. Our results highlight the importance of exploring population genetics to understand and predict COVID-19 outcomes. Indeed, further studies are needed to validate these findings as well as to identify new genetic determinants linked to SARS-CoV-2.
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Reports on the topic "SARS-CoV-2 (SARS2)"

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Urbatsch, Dana. Monitoring SARS-CoV-2 in wastewater. Office of Scientific and Technical Information (OSTI), July 2022. http://dx.doi.org/10.2172/1878019.

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Urbatsch, Dana. Monitoring SARS-CoV-2 in wastewater. Office of Scientific and Technical Information (OSTI), August 2022. http://dx.doi.org/10.2172/1881788.

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Paul, Satashree. Crosstalk Between Lung Cancer and SARS-CoV-2. Edited by Nature Library. Nature Library, September 2020. http://dx.doi.org/10.47496/nl.blog.06.

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Gleasner, Cheryl, Kimberly Mcmurry, Julia Kelliher, and Andrew Hatch. Illumina Sequencing for SARS-CoV-2 Training [Slides]. Office of Scientific and Technical Information (OSTI), May 2021. http://dx.doi.org/10.2172/1782612.

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Jüni, Peter, Antonina Maltsev, Pavlos Bobos, Upton Allen, Yoojin Choi, James P. Connell, Gerald A. Evans, et al. The Role of Children in SARS-CoV-2 Transmission. Ontario COVID-19 Science Advisory Table, August 2020. http://dx.doi.org/10.47326/ocsat.2020.01.03.1.0.

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Sola, Isabel. Estrategias para controlar al nuevo coronavirus SARS-Cov-2. Sociedad Española de Bioquímica y Biología Molecular, March 2020. http://dx.doi.org/10.18567/sebbmdiv_actu.2020.03.1.

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Negrete, Oscar, Steven Bradfute, Steven Larson, Anupama Sinha, Kenneth Coombes, Ronald Goeke, Lisa Keenan, et al. Photocatalytic Material Surfaces for SARS-CoV-2 Virus Inactivation. Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1669200.

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Chan, Wanyu. SARS-CoV-2 Transmission Control in California Correctional Facilities. Office of Scientific and Technical Information (OSTI), October 2022. http://dx.doi.org/10.2172/1891334.

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Leitner, Thomas. Tracking the SARS-CoV-2 Epidemic Using the Evolutionary Rate. Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1659156.

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Gans, Joshua. Test Sensitivity for Infection versus Infectiousness of SARS-CoV-2. Cambridge, MA: National Bureau of Economic Research, September 2020. http://dx.doi.org/10.3386/w27780.

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