Journal articles on the topic 'Sarat Chandra'

Sarat Chandra Chatterjee has portrayed female characters from southern Bengal who struggle in a conservative patriarchal society. His female characters are in the interposed stage of decomposing feudalism and initial industrialization. He delineates boldly the pain and torment of lower-middle class women. Sarat demonstrates many widows as “fallen women” in Srikant and Charitrahin which projects their space as a reinforcement of purity amidst a grovelling atmosphere of general dirt. The women must have purity, virtue and integrity otherwise they become victimized by the conservative patriarchal society. Most of his women characters share an extraneous relationship with society. Sarat demonstrates the complex conundrums of widows’ sufferings, child-marriage, disease, poverty, public bias and fallen women’s victimization which focused his perception of social realism. He also satirically represents the prevalent system of child-marriage and dowry which has infested the so-called modern society asserts to bring the estimation of women at par with that of men.

The works of literary masters often encapsulate history and anthropology of their times. Of several doyens of colonial writers in Bengal, Sarat Chandra Chattopadhyaya is well known for mirroring the position of women and also drawing some strong sketches of women reflecting social issues as well as inequality and injustice meted out to them at that period of Bengal’s history. His empathetic concern for women and his keen insight into their minds has often been commented on and appreciated. This paper is concerned with his inter-subjective relationship with the questions of class and caste and how, he as a male member of upper caste and from a genteel background dealt with his innate caste and class concerns in constructing his women characters representing various strata of society.

This research paper attempts a comparative study between Sarat Chandra Chattopadhaya’s novel Grihadaha and Gustave Flaubert’s Madame Bovary. The exploration involves a comparative analysis of the dreams and desires of the female protagonists in relation to the social and cultural norms of the times in which the novels are set with an intention to evaluate how the respective societies treat these women. Initially, both texts were closely read and analyzed separately for better understanding. Then the texts were read comparatively to identify the similarities and the differences. The study led to the discovery that be it the conservative Bengali society or the comparatively lenient French society, the pursuit, and fulfillment of the dreams and desires of women are always restricted in favor of patriarchy. Men enjoy privileges that are not offered to women and societies are often inherently hypocritical and unjustifiable.

Rokeya Sakhawat Hossain (1880-1932) is often considered as one of the most significant figures in the education and emancipation of Bengali (Muslim) women, especially during the early decades of the twentieth century. A contemporary of Rabindranath Tagore (1861-1941), Sarat Chandra Chattapadhyay (1876-1938) and Kazi Nazrul Islam (1899-1976), she was not only a brilliant writer but also one who passionately fought for the rights and dignity of women, as well as for women’s social, economic, and intellectual empowerment. Here I would like to argue that Rokeya’s efforts in educating and emancipating Indian women in general, and Bengali Muslim women in particular, were part of a larger social reform program or movement which began in Bengal in the early decades of the nineteenth century and lasted through the first half of the twentieth century, eventually resulting in a change in the course of Bengal’s history, as well as in the fate and circumstances of Bengali (Muslim) women. In other words, I contend that Rokeya was influenced and inspired by this movement in taking up the gauntlet against the deeply entrenched patriarchy that shaped the mind and habits of her society.

Televisi sebagai salah satu media masa, dihandalkan perusahaan (penjual barang ataupun penawar jasa) untuk mengomunikasikan produknya dengan cara yang begitu “lembut” dan “elegan”. Hal ini tidak lain lantaran dalam menjalankan fungsi informasi, edukasi, dan hiburannya, televisi sarat kepentingan dan ideologi yang berlomba mempengaruhi audiens. Talkshowberkekuatan “menyihir” pemirsa lantaran bersanding dengan setting(visual) santai dan paparan percakapan (audio) yang membuat perbincangan mudah dicerna. Makna, mitologi dan ideologi yang terselubung dalam setiap tanda verbal dan nonverbal hostCerdas 5 Menit Metro TV layak dikaji secara mendalam. Penelitian ini menggunakan teori terkait kajian kritis semiotika, talkshow, serta kajian elemen verbal dan nonverbal. Adapun paradigma kritis berjalan beriringan dengan teori semiotika Roland Barthes berfungsi sebagai pisau analisis yang mengkaji pesan linguistik, pesan ikonik terkodekan dan pesan ikonik tidak terkodekan. Hasil penelitian yang didapatkan adalah pergeseran makna atas tanda verbal dan nonverbal Chandra Dewi selaku host, baik dari segi ekspresi, gerakan kepala dan tangan, hingga pelafalan dan atribut yang digunakan berikut elemen pendukung keberadaannya sebagai hostCerdas 5 Menit. Hal ini dirangkum dalam 4mitologi kunci, antara lain transformasi makna,gaya hidup, keberpihakan, serta kepentingan materialistis. Keempat mitologi ini mengantarkan pada ideologi kapitalismeyang dimiliki oleh hostCerdas 5 Menit Metro TV. Talk shows have the power to "bewitch" the audience because they are coupled with a relaxed (visual) setting and conversation exposure (audio) that makes the conversation easy to digest. The meaning, mythology, and ideology that are shrouded in every verbal and nonverbal sign of Host at the “Cerdas 5 Menit Metro TV” deserve to be studied in depth. This study uses theories related to semiotic critical studies, talk shows, and the study of verbal and nonverbal elements. The critical paradigm goes hand in hand with the theory of semiotics Roland Barthes functions as a knife of analysis that examines linguistic messages, coded iconic messages and uncoded iconic messages. The results obtained are a shift in the meaning of verbal and nonverbal signs Chandra Dewi as the host, both in terms of expression, head and handmovements, to pronunciation and attributes used along with supporting elements of its existence as a Host at the “Cerdas 5 Menit Metro TV”. This is summarized in 4 key mythologies, including the transformation of meaning, lifestyle, partisanship, and materialistic interests. These four mythologies usher in the ideology of capitalism that is owned by Host at the “Cerdas 5 Menit Metro TV”.

Tulisan ini mengkaji mengenai diskresi seponering. Seponering adalah hak istimewa Jaksa Agung untuk mengesampingkan perkara atau memetieskan suatu perkara karena alasan kepentingan umum setelah mendapat saran atau masukan dari institusi terkait dibidang hukum. Mensikapi tentang seponering kasus Bibit Samad Rianto dan Chandra Martha Hamzah dalam pandangan hukum pidana Islam itu adalah adil. Mengingat kedua orang tersebut sebagai pimpinan Komisi Pemberantasan Korupsi yang mempunyai tugas berat dan besar. Namun sebagai muslim memberi catatan khusus bahwa pertama, Bibit Samad Rianto dan Chandra Martha Hamzah harus mengembalikan semua uang hasil korupsi kepada negara, kedua Bibit Samad Rianto dan Chandra Martha harus minta maaf kepada publik melalui media dan berjanji tidak akan mengulangi perbuatan itu. This article examines the Seponering discretion. Seponering is the privilege of the Attorney General to override or freeze a court case for reasons of public interest after getting feedback from the relevant institutions in the field of law. In response about Seponering case of Bibit and Chandra Martha Hamzah in the view of Islamic criminal law is fair. Considering that the two men are the leaders of the Corruption Eradication Commission which have heavy and bulky duty. but Muslims, they are given a special note that first, Bibit and Chandra Martha Hamzah should return all the corruption money to the state, both Bibit and Chandra Martha have to apologize to the public through the media and vowed not to reiterate the act.

Abstract Background: In trials of HER2+ metastatic breast cancer (mBC), trastuzumab deruxtecan (T-DXd) monotherapy showed durable efficacy (DESTINY-Breast01) and significantly prolonged progression-free survival vs trastuzumab emtansine (DESTINY-Breast03). T-DXd is approved in the US for patients with HER2+ unresectable/mBC who received ≥1 prior anti-HER2–based treatment (tx) in the metastatic or neo-/adjuvant setting and recommended for approval in the EU as 2nd-line tx. Preclinical data suggest that T-DXd used in combination with other anticancer tx may lead to improved efficacy. The purpose of DB-07 is to assess the safety and efficacy of T-DXd alone or with other anticancer tx for patients with HER2+ mBC. Here we report preliminary data from the DB-07 dose-expansion phase for T-DXd monotherapy and T-DXd + pertuzumab (P) as 1st-line (1L) tx in mBC. Methods: DB-07 (NCT04538742) is an ongoing, phase 1b/2, 2-part (part 1: dose finding; part 2: dose expansion), modular, open-label trial of T-DXd alone or with other anticancer tx in patients with HER2+ mBC. In part 2, patients in module (mod) 0 received T-DXd 5.4 mg/kg every 3 weeks (Q3W) and in mod 2, T-DXd 5.4 mg/kg + P 420 mg Q3W (loading dose: 840 mg), the recommended phase 2 dose. Patients in these mods must be mBC tx naive. For part 2, the primary objective is to assess safety and tolerability. A secondary objective is to assess the objective response rate (ORR) per local investigators by Response Evaluation Criteria In Solid Tumors v1.1. We report results for patients randomized before Oct 13, 2021 to mods 0 and 2 of part 2 (data cutoff [DCO]: Mar 4, 2022); recruitment is ongoing. Based on the distinct mechanism of action of T-DXd and P, we conducted preclinical studies with the drugs in HER2-overexpressing cell lines to elucidate their potential synergies. To assess the effects on T-DXd internalization, live cell imaging was performed using pH-dependent fluorescently labeled T-DXd. To assess the effects on HER2 signaling, total and p-HER2 levels and downstream substrates were evaluated by immunoblot. Results: 23 patients were enrolled in the T-DXd monotherapy mod; 20 (87.0%) were receiving tx and 3 (13.0%) discontinued tx (withdrawal by patient, n=2; adverse event [AE], n=1) by DCO. 22 patients were enrolled in the T-DXd + P mod; 20 (90.9%) were receiving tx and 2 (9.1%) discontinued tx (AE, n=1; disease progression, n=1) by DCO. All patients experienced AEs (Table); 1 patient in each mod died. The unconfirmed ORR (80% CI) with T-DXd monotherapy and T-DXd + P was 82.6% (68.2%-92.2%) and 77.3% (61.9%-88.5%), respectively; updated data will be presented. Preclinical studies showed that T-DXd was more rapidly and effectively internalized in combination with P than when administered alone. Immunoblotting of cell lysates showed a greater reduction in total HER2 and HER2 signaling in response to combination tx than with T-DXd or P alone. Discussion: In summary, 1L T-DXd monotherapy and T-DXd + P safety profiles and antitumor activity were consistent with those previously reported for T-DXd. Mature data in these mods are awaited, and other T-DXd combinations are being investigated in additional mods. Preclinical studies showed the potential for P to induce greater internalization of T-DXd and inhibition of HER2-driven signaling. These results support investigation of T-DXd in larger ongoing trials (eg, NCT04784715). Table 1: Summary of treatment duration and safety data Citation Format: Erika Hamilton, Komal Jhaveri, Sherene Loi, Carey Anders, Peter Schmid, Konstantin Penkov, Elena Artamonova, Lyudmila Zhukova, Daniil L. Stroyakovsky, Dinesh Chandra Doval, Rafael Villanueva, Flavia Michelini, Sarat Chandarlapaty, Matt Wilson, Sarice R. Boston, Adam Konpa, Shoubhik Mondal, Fabrice Andre. Dose-Expansion Study of Trastuzumab Deruxtecan as Monotherapy or Combined With Pertuzumab in Patients With Metastatic Human Epidermal Growth Factor Receptor 2-Positive (HER2+) Breast Cancer in DESTINY-Breast07 (DB-07) [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr PD18-11.

An experiment was conducted in the experimental farm of Bidhan Chandra KrishiViswavidyalaya, Nadia, West Bengal to study the radiation pattern and its balance over green gram (Vignaradiata var. Samrat). The BREB method was used to determine the sensible heat flux and latent energy. The net radiation was measured through net radiometer and the ground heat flux was measured using Fourier's law. Both the diurnal and seasonal variation of net radiation were studied. Similarly, the energy balance components were studied regularly for different crop growth stages as well as on diurnal basis. It is observed that the net radiation varies from 6.32 Wm-2 to 606.43 Wm-2. The latent heat flux constitutes more than 50% of the net radiation for all growth stages as depicted by energy balance partitioning. The sensible heat flux is partitioned into 10% to 20% of total net radiation throughout the growth stages of green gram, which is the lowest in magnitude among all three energy fluxes. The relationship between Bowen ratio and Vapour pressure deficit (VPD), Bowen ratio and Canopy air temperature difference (CATD) was studied. It was found that Bowen ratio is negatively correlated with VPD but positively correlated with CATD. This study enables to monitor ET pattern through latent heat flux and microclimatic characteristics through sensible and ground heat flux.

Eight genotypes of greengram were collected in the present investigation from AICRP on MULLaRP, Bidhan Chandra Krishi Viswavidyalaya (BCKV) and they were characterized with ten quantitative, nineteen qualitative and two biochemical parameters as per the NBPGR descriptor. Grouping based on DUS descriptors indicate the existence of genetic diversity within the genotypes. These eight genotypes were evaluated and characterized for 31 DUS descriptors. However, 21 characters out of 31 characters of DUS descriptors differed significantly indicating a large and exploitable amount of genetic variability for the individual elite improved line profile development for identification and protection. The elite lines are similar for the important plant traits like semi erect and determinate growth habit but the development of erect types is the need of hour and indicates the incorporation of new germplasm for the improvement of this trait in the present material. Genotypes could be easily identified through some unique characters: SML-1822 could be identified amongst genotypes studied here in through its semi-erect growth habit, green stem colour with purple shade, dark green leaf colour, light yellow flower colour and bearing pods below canopy; identification of IPM-512-1 and TMB-37 could be made through seeds with drum shape and dull seed luster respectively; and Pusa Vishal through its leaves with dark green colour along with intermediate pod position and larger seed size. Samrat is having highest amount of protein as well as carbohydrate content among these genotypes. Thus, the DUS descriptor data generated with unique profiles of the elite improved lines can be used for the registration with PPV & FRA and seed purity testing.

The July-September 2000 (Vol 25, No 3) issue of Vikalpa had published a Management Case titled Erhardt+ Leimer India Limited by S Kaushika Madhavan. In this issue, we feature 11 responses from Mahima Balakrishnan, Sujith Kumar Chandrasekaran and Bharat B Lalwani; Somya Bhatnagar, Samrat Chanda, Abbey Thomas and Sanchali Chakraborty; Anindita Ghosh, A Preeti, Y Mallikarjuna Reddy and Piyush Goyal; Mohit Kumar Jakhodia, Harry Jose, Saurabh Mittal, Yashpal Krishna Das and Abhishek Bansal; Pavan Jolly, Nidhi Gupta, Purvi Modi, Sheel Shah, Shantanu Mazumdar and Santosh Kurian T; Neeraj Kaushlendra, Sptarshi Ganguly and Sushmita Biswas; S Rajaram; V Venkata Rao; Dipankar Roy, Somnath Bondopadhaya, Maulik Singhal and Rajat Shrivastava; Anand Sridharan, V T Bharadwaj and N Ravichandran; and C Venkat. Erhardt+Leimer India Limited (ELIL), in the business of textile and related equipment manufacturing, is facing increased competition, stagnation in revenue, and eroded profitability. ELIUs parent company in Germany had implemented Enterprise Resource Planning (ERP) solutions to enhance its effectiveness and had offered ELIL some licences free of cost. Mr S Rajaram, Vice President (Operations) of ELIL, though excited about the possibility of adopting ERP solutions is also concerned about implementation issues. They are: inadequate computing infrastructure, need for substantial investment, need to improve process orientation, data discipline, the prevailing organizational culture, and the high rate of failure in ERP implementation. Considering that he has to make a recommendation to the Board on ERP implementation, he is wondering whether ELIL is prepared for this change.

An analysis of the present day Hindi, as spoken in the northern part of India, brings to light the fact that this language has at least twenty vowel phonemes, and not simply thirteen. Twelve of these twenty vowel phonemes are oral while eight of them are nasalized. Eighteen of them are pure vowels (monophthongs) while two of them are diphthongs. Two of the thirteen vowels included in the current list of alphabet have given place to two consonants with the result that they have ceased to exist. Most of these vowel phonemes occur in all the three positions, namely initial, medial and final, in the Hindi words. References Agnihotri, Rama Kant. (2007). Hindi: An Essential Grammar. London: Routledge. Chatterjee, Suniti Kumar. (1942). Indo-Aryan and Hindi: Eight Lectures. Ahmedabad: Gujarat Vernacular Society. Retrieved from: https://archive.org/details/in.gov.ignca.2478. Duncan Forbes. (1846). A Grammar of the Hindustani Language in the Oriental and Roman Character, London: W. H. Allen & Co. Retrieved from: https://ia801408.us.archive.org/ 27/items/agrammarhindstn00forbgoog/agrammarhindstn00forbgoog.pdf. Dwivedi, Kapildev. (2016). Bhasha Vigyan Evam Bhasha Shastra [Philology and Linguistics]. Varanasi: Vishvavidaya Prakashan. Greaves, Edwin. (1921). Hindi Grammar. Allahabad: Indian Press. Guru, Kamta Prasad. (2009 rpt. [1920]). Hindi Vyakaran [Grammar of Hindi]. New Delhi: Prakashan Sansthan. Koul, Omkar N. (2008). Modern Hindi Grammar. Springfield: Dunwoody Press. Pahwa, Thakardass. (1919). The Modern Hindustani Scholar; or, The Pucca Munshi. Jhalum: Printed at the Baptist Mission Press, Calcutta and published by the author. Shakespear, John. (1845). An Introduction to the Hindustani Language. Comprising a Grammar, and a Vocabulary, English and Hindustani. London: Wm. H. Allen & Co. Retrieved from: https://archive.org/details/introductiontohi00shakrich. Sharan, Ram Lochan. (1920). Hindi Vyakaran Chandrodaya [Chandrodaya Hindi Grammar]. Darbhanga: Hindi Pustak Bhandar. Sharma, Aryendra. (1994). A Basic Grammar of Hindi. Delhi: Central Hindi Directorate. Tiwari, Bhola Nath. (1958). Hindi Bhasha ka Saral Vyakaran [A Simple Grammar of Hindi]. Delhi: Rajkamal. Tiwari, Uday Narayan. (2009). Hindi Bhasha ka Udgam aur Vikas [Origin and Development of Hindi Language]. Allahabad: Lok Bharati, 2009. Tweedie, J. (1900). Hindustani as It Ought to be Spoken. London: W. Thacker. Retrieved from: https://archive.org/details/hindstniasitoug00tweegoog/page/n6. Verma, Ram Chandra. (1961) Manak Hindi Vyakaran [Standard Grammar of Hindi]. Varanasi: The Chaukhambha Vidya Bhawan. Sources www.wikihow.com/Learn-Hindi https://en.wikipedia.org/wiki/Devanagari

Abstract The KRASG12D mutation is an ideal target for anti-cancer therapies as its expression is typically clonal, restricted to cancer tissue, and is among the most common oncogenic drivers in solid tumors. TCR-T cell therapies have demonstrated clinical activity in some solid cancers but have been limited by heterogeneous antigen expression and unfavorable tumor microenvironments. By targeting the KRASG12D mutation for which the cancer has established genetic dependency, AFNT-212 is designed to selectively target all cancer cells while avoiding on-target/off-tumor toxicities. AFNT-212 is non-virally engineered to knock-in a 5-transgene cassette expressing a high-avidity TCR specific for the KRASG12D mutation, a CD8α/β coreceptor, and a chimeric cytokine receptor. Transgene insertion at the TRAC locus disrupts expression of the endogenous TCRα, further enhancing the expression/activity of the transgenic KRASG12D TCR. Primary human CD8+ and CD4+ T cells were genetically engineered by a novel CRISPR-Cas nuclease system to integrate AFNT-212 transgenes within the TRAC locus. A cGMP compatible scale-up process for non-viral knock-in was established to support AFNT-212 clinical manufacturing. The activity of AFNT-212 was assessed against a panel of human KRASG12D tumor cell lines in vitro and established mouse xenograft models in vivo. The preclinical safety profile of AFNT-212 was evaluated by X-scan and crossreactivity assessment, alloreactivity studies, and cytokine independent growth studies. The specificity of gene-editing (GE) was assessed by an unbiased oligo-capture method followed by targeted sequencing. AFNT-212 TCR-T cells demonstrated potent in vitro anti-tumor activity against endogenously expressing HLA-A*11:01 KRASG12D tumor cells, including during chronic exposure to viable tumor cells. AFNT-212 TCR-T cells showed robust antitumor activity in established xenograft mouse models in vivo. No cross-reactivity was identified for the KRASG12D TCR against potential self-peptides even at supraphysiological levels, demonstrating high specificity of the TCR. No alloreactivity or cytokine-independent proliferation was observed. GE safety evaluations did not reveal any off-target activity using high sensitivity (~0.1%) NGS-based analyses or any GE-associated chromosomal rearrangements. The manufacturing of AFNT-212 consistently delivered >50-fold expansion of engineered TCR-T cells to meet expected clinical dose levels and exhibit memory/stemness phenotypes and negligible markers of immunologic exhaustion. AFNT-212, a novel TCR T cell therapy targeting KRASG12D mutant tumors, demonstrates robust activity against KRASG12D mutant tumors in vitro and in vivo. The robust manufacturing process developed using non-viral gene editing in the TRAC locus will support future clinical development of AFNT-212. Citation Format: Allison Drain, Nicholas Rouillard, Nathaniel Swanson, Martina Canestraro, Santosh Narayan, Tyler Warner, Nicole Danek, Ken Gareau, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Iqraa Priyata, Sarah Vidyasagar, Taylor Riggins-Walker, Hui-Wen Liu, Klaus Pechhold, Lauren Brown, Joshua Francis, Xingyue He, Patrick Browne, Rebecca Lamothe, Meghan Storlie, Gregory Cost, Thomas M. Schmitt, Philip D. Greenberg, Smita S. Chandran, Christopher A. Klebanoff, Hubert Lam, Ankit Gupta, Damien Hallet, Gary Shapiro, Kim Nguyen, Loïc Vincent. AFNT-212: A TRAC-knocked-in KRASG12D-specific TCR-T cell product enhanced with CD8αβ and a chimeric cytokine receptor for treatment of solid cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 9.

Abstrak Kualitas Pelayanan merupakan sebagai ukuran seberapa bagus tingkat layanan yang diberikan mampu terwujud sesuai harapan pengguna. Kualitas Layanan itu sendiri ditentukan oleh kemampuan Instansi dalam memenuhi kebutuhan dan keinginan pengguna sesuai dengan ekspektasi pengguna. Kepuasan Masyarakat merupakan kegiatan pengukuran secara komprehensif tentang tingkat kepuasan masyarakat terhadap kualitas layanan yang diberikan oleh penyelenggara pelayanan publik. Indeks Kepuasan Masyarakat sebagai berikut : Persyaratan, Sistem mekanisme, Waktu penyelesaian, Biaya/tarif, Produk spesifikasi jenis layanan, Kompetensi pelaksanaan, Perilaku pelaksanaan, Penanganan pengaduan saran dan masukan, serta sarana dan prasarana. Menurut (Permenpan Nomor.14 Tahun 2017 ). Dari uraian diatas maka peneliti tertarik melakukan penelitian dengan Judul�Pengaruh Bukti Fisik / Tangible(X1), Perhatian / Emphaty (X2), Kehandalan/Reliability(X3),DayaTanggap/Responsiveness(X4), Jaminan / Assurance (X5) Terhadap Kepuasan Masyarakat Pengguna Layanan Pada Kantor Urusan Agama Kecamatan Karau Kuala Tahun 2022�. Teori yang digunakan dalam penelitian ini yaitu Kualitas Pelayanan Menurut Lewis & Booms dalam Tjiptono & Chandran (2016). dan Kepuasan Masyarakat menurut Permenpan Nomor.14 Tahun 2017. Alat analisis yang digunakan yaitu Regresi Linier Berganda dengan menggunakan SPSS versi 25. Pada Tabel 4.50 Hasil yang diperoleh dalam perhitungan Regresi Linier Berganda adalah Y = 19,888 + 0,819 + 3,202 + 0,391 + (-2,123) + 1,257. Berdasarkan hasil analisis regresi pada tabel 4.60 diperoleh nilai (Fhitung > Ftabel) (18,635 > 2,38) dan nilai (Signifikan < 0,05) (0,000 < 0,05). Maka dapat disimpulkan Ho di tolak dan Ha diterima yang artinya Bukti Fisik/Tangible, Perhatian/Emphaty, Kehandalan/Reliability, Daya Tanggap/Responsivenes, Jaminan/Assurance secara simultan (bersama-sama) berpengaruh signifikan terhadap Kepuasan Masyarakat. Hipotesis dalam penelitian ini yaitu H?=Bukti Fisik/Tangible secara parsial berpengaruh terhadap Kepuasan Masyarakat, H?=Perhatian/Emphaty secara parsial tidak berpengaruh terhadap Kepuasan Masyarakat, H?= Kehandalan/Reliability secara parsial tidak berpengaruh terhadap Kepuasan Masyarakat, H?= Daya Tanggap/Responsivenes secara parsial tberpengaruh terhadap Kepuasan Masyarakat, H?=Jaminan/Assurance secara parsial tidak berpengaruh terhadap Kepuasan Masyarakat, H?= Kepuasan Masyarakat secara parsial berpengaruh terhadap Kepuasan Masyarakat. secara simultan. Abstract . Service quality is a measure of how well the level of service provided can be realized according to user expectations. Service quality itself is determined by the agency's ability to meet user needs and desires in accordance with user expectations. Community Satisfaction is a comprehensive measurement activity of the level of community satisfaction with the quality of services provided by public service providers. The Community Satisfaction Index is as follows: Requirements, Mechanism system, Completion time, Cost/tariff, Product specification type of service, Implementation competence, Implementation behavior, Handling complaints, suggestions and inputs, as well as facilities and infrastructure. According to (Permenpan No. 14 of 2017). From the description above, the researcher is interested in conducting research with the title "The Influence of Physical Evidence / Tangible (X1), Attention / Empathy (X2), Reliability / Reliability (X3), Responsiveness / Responsiveness (X4), Guarantee / Assurance (X5) On Community Satisfaction Service Users at the Karau Kuala District Religious Affairs Office in 2022". The theory used in this research is Service Quality According to Lewis & Booms in Tjiptono & Chandran (2016). and Community Satisfaction according to Permenpan Number 14 of 2017. The analytical tool used is Multiple Linear Regression using SPSS version 25. In Table 4.50 the results obtained in the calculation of Multiple Linear Regression are Y = 19.888 + 0.819 + 3.202 + 0.391 + (-2.123) + 1.257. Based on the results of the regression analysis in table 4.60, the value (Fcount > Ftable) (18,635 > 2,38) and the value (Significant < 0.05) (0.000 < 0.05). So it can be concluded that Ho is rejected and Ha is accepted, which means that Physical/Tangible Evidence, Attention/Emphaty, Reliability/Reliability, Responsiveness/Responsiveness, Guarantee/Assurance simultaneously (together) have a significant effect on Community Satisfaction. The hypothesis in this study is that H?=Physical/ Tangible Evidence partially affects Community Satisfaction, H?=Attention/Empathy partially does not affect Community Satisfaction, H?= Reliability/Reliability partially does not affect Community Satisfaction, H?= Responsiveness/Responsiveness Partially t has an effect on Community Satisfaction, H? = Guarantee/Assurance partially has no effect on Community Satisfaction, H? = Community Satisfaction partially has an effect on Community Satisfaction. simultaneously.the independent (X) Work Discipline and the dependent variable (Y) Employee Performance in the job training and workforce placement sections. Data processing techniques and data analysis used a Likert scale (questionnaire), simple linear regression analysis and simple regression coefficient test (t test) using the Windows application SPSS statistics version 25 program to test the results of calculations in the data analysis. The results obtained in the calculation of simple linear regression are Y = 18.628 + 0.553 x where the value (a) is 18.628; and the coefficient value (b) is 0.553. Then the results of tcount> from the above test show that tcount> ttable (3,374? t table 2,051) then Ho is rejected and Ha is accepted, meaning that there is an effect of Work Discipline on Employee Performance at the Manpower and Transmigration Service of South Barito Regency in 2021. Based on the conclusion, it can be seen that the effect of work discipline on employee performance in the Job Training Section and placement of workers at the Manpower and Transmigration Office of South Barito Regency in 2021 is important because it can improve employee performance in carrying out their respective duties according to job des.

Abstract Background: 2.1 million breast cancers are newly diagnosed each year. Current guidelines endorse routine testing for estrogen receptor (ER) and progesterone receptor (PR), while use of the Ki67 biomarker can provide additional prognostic value. All three biomarkers currently require quantitative evaluation using manual review of a glass slide, resulting in reproducibility issues across labs due to interpretative and scoring variabilities. Current on-market image analysis algorithms only offer limited field-of-view (FOV) that analyze a tiny fraction of the entire tissue. Whole slide image (WSI) analysis, in comparison, analyzes the entire tissue and, therefore, more closely mimics how pathologists assess these slides in clinical practice. In this work, we developed three deep learning artificial intelligence (AI) based algorithms for WSI analysis (IA) of digitized images from Ki67, ER, and PR stained slides that address these variabilities and allow pathologists across labs to consistently score at the same accuracy as selected expert labs. The complete software solution delivers high throughput analyzing whole-slide images in less than 2 minutes during pre-computation on conventional computer hardware and returning results on user-provided annotations in milliseconds. Methods: We assembled a benchmark validation data set of 312 breast cancer cases (100 Ki67, 102 ER, and 110 PR slides, stained at multiple sites) representative of breast cancer subtypes (i.e. ductal, lobular, mucinous, medullary, tubular), score (i.e. 0%-100% positivity), tumor grade (i.e. well, moderately, and poorly differentiated), and specimen type (i.e. biopsy and resection). Three pre-clinical validation studies were performed using the Roche uPath enterprise software and each of the ER, PR and Ki67 image analysis algorithms. A total of 6 pathologists participated in the study split into expert (n=3) and study (n=3) readers. A non-inferiority Ground-Truth (GT) study design was implemented in which the study and expert readers performed manual read (MR) followed by AI-assisted scoring. The expert manual scores were used as GT to which the readers’ manual and AI scores were compared for each marker and case. Results: The overall concordance rates between AI scores and expert GT was as follows: For Ki67, OPA=97.2% (95% CI: 94.0, 99.7), NPA=97.8% (95% CI: 93.4,100), and PPA=96.7% (95% CI: 91.3, 100), for ER, OPA=95.4% (CI:91.4,98.4), NPA=96.4% (CI:92.5,99.4), and PPA=94.4% (CI:87.4,100), and for PR, OPA=96.1% (95% CI:92.7,99.1), NPA=96.7% (95% CI:92.5,100), and PPA=95.6% (95% CI:89.9,100). The differences between AI and MR overall concordance rates (AI-MR) when compared to the expert GT were: for Ki67: OPA-diff=1.4% (2-sided 95% CI:-0.7,3.7), NPA-diff=3.8% (CI:0.6,7.8), PPA-diff=-1.0% (CI:-3.5,0.0), for ER: OPA-diff=-0.9% (CI:-3.3,1.0), NPA-diff=-0.1% (CI:-3.1,3.0), PPA-diff=-1.8% (CI:-6.2,0.0), and for PR: OPA-diff=-1.5% (CI:-3.9,0.6), NPA-diff=-2.4% (CI:-6.8,1.2), PPA-diff= -0.7%(CI:-2.8,1.1) using the cutoffs 20% (Ki67), 1% (ER), and 1% (PR) respectively. Conclusion: Our preliminary feasibility data shows that pathologists using WSI analysis assisted scoring was equivalent to manual scoring and an expert panel GT using a truly representative benchmark data set. Additionally, image analysis algorithms are known to provide high reproducibility and precision. We will provide those numbers at a later stage as they were not fully available at time of submission. Our results show the value and potential of deep learning technologies to improve the diagnosis and care of patients with breast cancer. Citation Format: Monesh Kapadia, Mehrnoush Khojasteh, Margarita Kouzova, Carol Jones, Xiao-Meng Xu, Matthew T. Olson, Sarah Gladden, Nancy Sapanara, Shalini Singh, Chen Chun Chen, Isaac Bai, Jim Ranger-Moore, Landon J. Inge, Uday Kurkure, Ipshita Bhattacharya, Margaret Zhao, Karel Zuiderveld, Chandana Chintakindi, Bryan Lopez, Christoph Guetter. Artificial intelligence-based whole slide scoring of nuclear breast cancer IHC markers Ki67, ER, and PR matches performance of manual clinical scoring [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-02-17.

ABSTRAK Sektor kosmetik halal saat ini dianggap sebagai sektor dengan potensi tertinggi secara global. Berkembangnya tren penggunaan kosmetik halal dipengaruhi oleh tren hijrah dan gaya hidup umat Muslim yang sadar dengan urgensi penggunaan produk halal. Ketersediaan produk kosmetik halal yang beragam di pasaran mendorong konsumen lebih diskriminatif dalam pemilihan merek kosmetiknya. Perusahaan perlu merumuskan strategi pemasaran yang tepat agar produknya dapat bertahan dan bersaing dengan kompetitor, salah satunya melalui rekomendasi atas suatu produk tertentu. Penelitian ini bertujuan untuk menganalisis faktor yang mempengaruhi intensi konsumen untuk merekomendasikan produk kosmetik halal. Metode yang digunakan dalam penelitian yaitu Structural Equation Modelling (SEM) dengan alat analisis SmartPLS 3. Data primer diperoleh melalui kuesioner dengan 180 sampel masyarakat di Kota Tangerang Selatan. Hasil penelitian mengungkapkan bahwa customer satisfaction, product quality, dan customer experience berpengaruh secara positif dan signifikan terhadap intention to recommend produk kosmetik halal, sedangkan trust tidak berpengaruh secara signifikan terhadap intention to recommend produk kosmetik halal. Kata kunci: Kosmetik halal, customer satisfaction, trust, product quality, customer experience, intention to recommend. ABSTRACT The halal cosmetics sector is currently considered the sector with the highest potential in the world. The growing trend of using halal cosmetics is influenced by the migration trend and lifestyle of Muslims who are aware of the importance of using halal products. The presence of various halal cosmetic products on the market encourages consumers to be more selective in their choice of cosmetic brands. Companies need to formulate the right marketing strategy in order for their products to survive and compete with competitors, one of which is product-specific recommendations. This study aims to analyze the factors that influence consumers' intentions to recommend halal beauty products. This study used Structural Equation Modeling (SEM) with the SmartPLS 3 analysis tool. Primary data was obtained from a survey of 180 samples of people in the city of South Tangerang. The results of the study show that customer satisfaction, product quality, and customer experience have a positive and significant impact on the intention to recommend halal beauty products, while trust does not have a significant effect on the intention to recommend halal beauty products. Keywords: Halal cosmetics, customer satisfaction, trust, product quality, customer experience, intention to recommend. DAFTAR PUSTAKA Abu Bakar, E., Rosslee, N. N., Mastura, A., Ariff, M., Othman, M., & Hashim, P. (2017). Consumers’ trust and values towards halal cosmetics and personal care products. Malaysian Journal of Consumer and Family Economics. Adriyati, R., & Indriani, F. (2017). Pengaruh electronic word of mouth terhadap citra merek dan minat beli pada produk kosmetik wardah. Diponegoro Journal of Management, 6(4), 1–14. Ahmadi, A. (2019). Thai Airways: Key influencing factors on customers’ word of mouth. International Journal of Quality and Reliability Management, 36(1), 40–57. https://doi.org/10.1108/IJQRM-02-2018-0024 Ajzen, I. (1988). Attitudes, personality and behavior. Open University Press. Al-Ansi, A., Olya, H. G. T., & Han, H. (2019). Effect of general risk on trust, satisfaction, and recommendation intention for halal food. International Journal of Hospitality Management, 83, 210–219. https://doi.org/10.1016/j.ijhm.2018.10.017 Ali, F., Kim, W. G., Li, J., & Jeon, H. M. (2018). Make it delightful: Customers’ experience, satisfaction and loyalty in Malaysian theme parks. 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Journal of Quality Assurance in Hospitality and Tourism, 19(4), 442–459. https://doi.org/10.1080/1528008X.2018.1429981 Iglesias, O., Singh, J. J., & Batista-Foguet, J. M. (2011). The role of brand experience and affective commitment in determining brand loyalty. Journal of Brand Management, 18(8), 570–582. https://doi.org/10.1057/bm.2010.58 Ishak, S., Che Omar, A. R., Khalid, K., Intan, I. S., & Hussain, M. Y. (2020). Cosmetics purchase behavior of educated millennial Muslim females. Journal of Islamic Marketing, 11(5), 1055–1071. https://doi.org/10.1108/JIMA-01-2019-0014 Izogo, E. E. (2016). Structural equation test of relationship quality: Repurchase intention – willingness to recommend framework in retail banking. International Journal of Emerging Markets, 11(3), 374–394. https://doi.org/10.1108/IJOEM-07-2015-0130 Jani, D., & Han, H. (2014). Personality, satisfaction, image, ambience, and loyalty: Testing their relationships in the hotel industry. 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Determinants of purchase intention of halal cosmetic products among Generation Y consumers. Journal of Islamic Marketing, 12(8), 1461–1476. https://doi.org/10.1108/JIMA-11-2019-0248 Kim, H. S., & Choi, B. (2016). The effects of three customer-to-customer interaction quality types on customer experience quality and citizenship behavior in mass service settings. Journal of Services Marketing, 30(4), 384–397. https://doi.org/10.1108/JSM-06-2014-0194 Kotler, P., & Armstrong, G. (2018). Principles of marketing. London: Pearson Education Limited. Kotler, P., & Keller, K. L. (2012). Marketing management. London: Pearson Education. Kraeuter, S. G. (2002). The role of consumers’ trust in online-shopping. Journal of Business Ethics, 39(1), 43–50. http://dx.doi.org/10.1023/A:1016323815802 LPPOM MUI. (2021). LPPOM: Wajib sertifikasi halal juga berlaku untuk produk kosmetik. Retrieved from https://mui.or.id/berita/32650/lppom-wajib-sertifikasi-halal-juga-berlaku-untuk-produk-kosmetik/ Marques, C., Vinhas da Silva, R., & Antova, S. (2021). Image, satisfaction, destination and product post-visit behaviours: How do they relate in emerging destinations? Tourism Management, 85. https://doi.org/10.1016/j.tourman.2021.104293 Meilatinova, N. (2021). Social commerce: Factors affecting customer repurchase and word-of-mouth intentions. International Journal of Information Management, 57. https://doi.org/10.1016/j.ijinfomgt.2020.102300 Morgan, R. M., & Hunt, S. D. (1994). The commitment-trust theory of relationship marketing. Journal of Marketing, 58(3), 20–38. https://doi.org/10.2307/1252308 Oliveira, T., Tomar, S., & Tam, C. (2020). Evaluating collaborative consumption platforms from a consumer perspective. Journal of Cleaner Production, 273. https://doi.org/10.1016/j.jclepro.2020.123018 Oliver, R. L. (1980). 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<p><em>The history of Indian Subcontinent is the history of friendship and hatred, trust and suspicion and conflict and cooperation between the two communities Hindus and Muslims. The two nation states (and later three), that were carved out of this subcontinent formed the part of the single nation which was the undivided India. The two countries India and Pakistan despite being the parts of one single civilization are generally seen as the arch rivals of one another.</em></p><p><em>In many ways there are no two countries in the world which have so much in common as India and Pakistan. Parts of the same state, India and Pakistan have more common heritage and interests than probably any other two countries in the world. Mohenjo-Daro and Harappa in Pakistan are as much part of India’s history as Delhi, Agra, Ajmer and Lucknow are of Pakistan; at least four languages are spoken commonly in both the countries and the two national languages of Pakistan are two national languages of India as well; the same literary figures are held in the highest esteem – Tagore and Iqbal, Nazrul Islam and Waris Shah, Ghalib and Sarat Chandra Chatterjee; dresses are common in large parts of India and Pakistan, food habits, manners, customs and even the humor are common. Music and dancing, art and painting draw common inspirations and observe common forms¹. For centuries, people of both the countries have lived on the same land mass, have faced the heat and dust, the cold and snow together have gone through the national calamities such as famine and drought and floods together. And then together they saw the rulers come from the far away land and they tasted the dust of common humiliation. And in the initial stages, they even started fighting the foreign ruler together. The bondage of history, geography and culture is too strong to be overlooked. </em></p>

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh pendekatan saintifik terhadap kemampuan sains permulaan anak. Jenis penelitian ini adalah pra-eksperimen dengan One Group Pretest-Posttest Design. Populasi dalam penelitian ini adalah 20 anak kelompok B3 TK Sila Chandra I Batubulan Kecamatan Sukawati. Sampel dalam penelitian ini menggunakan teknik sampel jenuh. Data yang dikumpulkan menggunakan metode tes objektif, hasil tersebut dianalisis menggunakan uji-t. Hasil penelitian menunjukkan nilai rata-rata post-test (82,60) lebih tinggi daripada nilai rata-rata pre-test (70,00). Uji statistik menunjukkan bahwa thitung ≥ ttabel dengan harga thitung 74,11 dan harga ttabel 2,093 maka H0 ditolak dan Ha diterima pada taraf signifikansi 5 % dengan dk=19. Ini berarti terdapat pengaruh pendekatan saintifik terhadap kemampuan sains permulaan anak Kelompok B3 TK Sila Chandra I Batubulan Kecamatan Sukawati Tahun Ajaran 2017/2018. Berdasarkan hasil penelitian ini, maka saran yang dapat diberikan hendaknya dalam sebuah pembelajaran seorang pendidik atau guru memilih pendekatan yang tepat dalam merancang kegiatan sains melalui percobaan-percobaan sederhana. Kata Kunci : Kata Kunci: Pendekatan saintifik, kemampuan sains permulaan, percobaan sederhana ABSTRACT This research was aimed to determine the influence of scientific approaches to the early child’s science skills. The type of this research was pre-experiment with used One Group Pretest-Posttest Design. of science group B3 in Sila Chandra I Batubulan Kindergarten academic year 2017/2018. Population in this research is 20 child group B3 in Sila Chandra I Batubulan Kindergarten. The sample in this research used saturated sample technique that was all the group B3 of children in Sila Chandra I Batubulan Kindergarten which amounted 20 persons. Sample in this research use saturated sample technique. Data collacted using objective test method, the result is analyzed using t-test. Research results showed the average post-test (82,60) higher than the average pre-test (70,00). The satistical test shows that the price The result of hypothesis test shows that tcount ≥ ttable was 74,11 ≥ 2,093 with dk = 19 and significance level 5%, so H0 was rejected and Ha was accepted. Based on the results obtained, it could be concluded that there was a significant influence on the used scientific approach to the early science skills of children group B3 in Sila Chandra I Batubulan Kindergarten academic year 2017/2018. Based on the results of this study, suggestions should choose the appropriate approach in designing science activities through simple experiments. keyword : Keywords: Scientific approach, early science skills, simple experiment.

Though translation activities are more than two millennia old, the most significant activities in this field took place in the 20th century. To be specific, contradictory theoretical positions were taken and entirely new kinds of questions were asked in the second half of this century. Scholars like Susan Bassnett (1998) even claimed that a translation should be treated as an independent and original text. But a number of writers, translators and scholars hold an opposite view. If we consider the translation activities of the ancient western civilizations of the world, we notice that those were mostly commissioned and literal in nature. Contrary to it, the situation in India was different. Though Valmiki and Vyasa composed the Ramayana and the Mahabharata respectively for the first time in Sanskrit, the Ramayanas and Mahabharatas written later in various vernacular languages of India are adaptations or transcreations. A careful analysis of the European, Arabic, and Chinese traditions show that those were literate in comparison with the vernacular Indian tradition that was predominantly oral. This orality gave a lot of freedom to the writers in the vernacular languages in ancient India to be creative and compose new texts. Therefore, orality was the driving force for this creativity and some western scholars’ proposal that a translated text is an original text in not a new concept. The other point I would like to make is that contrary to the popular belief, a literal translation of a literary text is also appreciated more (Newmark 1988:70-71). This position is validated in two of our case studies, i.e. Mohanty et al. (2008) and Mohanty and Sarath Chandra (2014). Therefore, I want to argue that ‘free’ translation was the mainstream in the climate of orality and not in literacy. This free trend endorsed by those scholars who treat translations as original texts is peripheral in the contemporary literate societies in which translations are usually commissioned. I will also argue that the differences between the free and the literal trends in translation are primarily due to the oral and the literate traditions that prevailed in India and in the other parts of the world mentioned above in the olden days.

Photo by Owen Beard on Unsplash Introduction Through its professional associations and healthcare organizations, the medical community has made numerous anti-racism statements in the past year, including the American Medical Association’s (“AMA’s) Organizational Strategic Plan to Embed Racial Justice and Advance Health Equity.[1] Converting these statements into practical change will take time and money. In addition to implementing anti-bias training and education on racism in clinical practice, the medical community should also advocate to enhance and enforce Title VI anti-discrimination laws. The current limitations on enforcement conflict with the medical community’s ethical duty to improve health equity and treat all patients with a high standard of care. Advocating for legislation that meets the standards of other civil rights laws to hold the healthcare industry legally responsible for discrimination should be part of medical professionals’ anti-racism work. Development of Civil Rights in Health Care Despite the lack of a federal constitutional right to health care, the United States does acknowledge the importance of health and health care through its laws and spending decisions. In 2010, the Affordable Care Act (“ACA”) created health insurance options for 20 million additional Americans and reduced the gap in healthcare access among populations.[2] Although it did not ensure a right to health care and it does not guarantee a right to health, healthcare access is an important element of a healthy life and broadening the reach of health insurance is a worthy goal. Outside of the ACA’s offer of affordable health insurance, only a few stakeholders have gained “weak” statutory rights to publicly funded health care such as incarcerated people, the elderly, disabled, and the very poor.[3] Yet, the adoption of the public insurance programs Medicaid and Medicare in 1965, along with Title VI of the 1964 Civil Rights Act (“Title VI”), did create some rights to sue for discrimination in health care, even for people who are not recipients of Medicaid and Medicare benefits. Under Title VI, private institutions that receive federal financial assistance are prohibited from discriminating on the basis of race, color, and national origin.[4] Initially, this civil rights legislation had a major effect on health care because more than 1000 segregated hospitals immediately integrated their facilities in order to comply with the legislation and participate in Medicaid and Medicare.[5] Medical professionals interested in anti-racist work would do well to learn the history of Title VI; grassroots support of civil rights laws in the 1960s encouraged huge steps forward in eliminating de jure segregation in health care.[6] Title VI Lacks Mechanisms to Combat Structural Racism Title VI has been less effective when addressing more subtle forms of discrimination. Despite being one of the broadest anti-discrimination statutes, Title VI has been referred to as a “sleeping giant” because its full power has not been used to great effect.[7] The ACA included some attempts to improve Title VI’s effectiveness (see below), but much more could be done. Like most civil rights laws, Title VI discrimination may be alleged as disparate treatment (intentional) or disparate impact. Disparate impact claims are challenging to prove and may involve arguments such as how moving a hospital from an inner-city area to a wealthier suburban location will have a disparate impact on the local Black population. Besides the evidentiary challenges involved in demonstrating disparate impact, such a claim fails unless the plaintiffs can prove that a reasonable explanation for the action, such as cost savings, is a pretext for discrimination.[8] Title VI claims are also challenging because of the limitation on plaintiffs, the limitation on the scope of defendants, and enforcement issues. In 2001, the US Supreme Court held that individual plaintiffs cannot sue under Title VI for disparate impact claims, requiring a federal agency to do so.[9] While hospitals and other entities are potential defendants under Title VI, individual medical professionals are not, even though approximately 40 percent of Medicaid and Medicare reimbursements now go to physician and outpatient care.[10] The primary enforcement mechanism for Title VI healthcare claims is forcing compliance with the law through the threat of withdrawal of federal reimbursement.[11] The threat of financial punishments may harm communities, however, when low-resourced hospitals lose funding or are forced to fund rehabilitation programs.[12] Inequities between hospitals in different locations currently cannot be addressed under Title VI. Recent attempts to improve Title VI have failed. In the ACA, legislators included several updates to Title VI that appeared to improve its potential as a tool for reducing healthcare inequities. Section 1557 of the ACA changed the definition of “federal financial assistance” programs to include Medicaid and Medicare Advantage, thus expanding the pool of possible defendants to include individual providers.[13] However, the Department of Health and Human Services issued an implementing rule that specifically did not include Medicare Part B, so as of now patients cannot bring suit against sue their doctors for Title VI discrimination.[14] Some authors argue that the ACA also repealed the Supreme Court decision that prevented individuals from bringing disparate impact claims under Title VI.[15] So far, however, courts still interpret Title VI as supporting private claims only for intentional discrimination.[16] Individuals can still bring disparate impact claims to the Office of Civil Rights (“OCR”) and the Federal government may take action on their behalf. Because of the lack of available private action, however, there is no robust group of Title VI attorneys developing these civil rights cases.[17] If the legislature wants to encourage private enforcement of Title VI discrimination cases, it could also add punitive and compensatory damages to the available remedies, as it did with Title VII employment discrimination cases,[18] thus empowering plaintiffs and their lawyers to seek private remedies for discrimination in health care. Private litigation could be used as an additional lever in strategic approaches to eliminating discriminatory practices and improving health equity.[19] In 2003, the Institute of Medicine’s Committee on Understanding and Eliminating Racial and Ethnic Disparities in Health Care recommended that the federal government increase funding for the OCR to encourage investigations into violations of Title VI based on systemic discrimination in health care.[20] The committee saw such enforcement as a “last line” of defense against systemic racism in health care, and a way to find such suspected racism through proactive investigations. Unfortunately, the OCR continues to be “notoriously” underfunded, but future administrations may be encouraged to rectify that problem.[21] Permitting more individual lawsuits may improve Title VI by providing better enforcement mechanisms and broadening the scope of possible defendants. These litigation tools will never bring about a right to health but can reduce inequities in access to and treatment in the healthcare system. Health professionals can support such proposals as individuals and through their professional associations. Of course, not all stakeholders agree that the federal government should enforce greater access to health care; after several states brought suit, the US Supreme Court struck down the ACA provision that would have effectively required states to expand Medicaid eligibility.[22] In addition, many health professionals will object to individual Title VI lawsuits. Distinguishing between malpractice litigation and discrimination litigation will be important so that healthcare practitioners do not feel their livelihoods are threatened by Title VI. If improving health equity and combating racism is seen part of one’s ethical duty, then medical professionals should embrace a willingness to be held accountable personally, and even more importantly, as part of a healthcare organization. The AMA has a well-documented history of racism, and the organization has apologized and sought atonement. Part of that history includes a failure to support civil rights legislation in the 1960s and active opposition to Medicare, Medicaid, and the desegregation of hospital staff.[23] Notably, the National Medical Association, an African American medical association, worked hard to support civil rights laws and integration in the 1960s, but could not convince the “White” AMA to follow suit. As part of its anti-racism efforts, the AMA could work with legislators to craft appropriate changes to Title VI and take on the task of educating its membership. Health professionals should understand that the shortcomings of Title VI in eradicating racism in health care were due to decisions about and interpretations of the law which were influenced by the medical profession itself. Educating all the stakeholders about the connections between health, healthcare access, and strong enforcement of our civil rights statutes and regulations is one way that health professionals can actively engage in anti-racism work in the healthcare profession. [1] “The AMA’s Strategic Plan to Embed Racial Justice and Advance Health Equity,” American Medical Association, accessed June 25, 2021, https://www.ama-assn.org/about/leadership/ama-s-strategic-plan-embed-racial-justice-and-advance-health-equity. [2] “How ACA Narrowed Racial Ethnic Disparities Access to Health Care | Commonwealth Fund,” accessed March 10, 2021, https://www.commonwealthfund.org/publications/2020/jan/how-ACA-narrowed-racial-ethnic-disparities-access. [3] Aeyal Gross and Colleen Flood, The Right to Health at the Public/Private Divide : A Global Comparative Study, New York (Cambridge University Press, 2014), , 348, https://web-a-ebscohost-com.ezproxy.cul.columbia.edu/ehost/ebookviewer/ebook/ZTAyNXhuYV9fNzcwMjExX19BTg2?sid=5201c555-548f-4599-ae3d-857f6911322f@sessionmgr4007&vid=0&format=EB&lpid=lp_261&rid=0. [4] Title VI of the 1964 Civil Rights Act, § 2000d (“No person in the United States shall, on the ground of race, color, or national origin, be excluded from participation in, be denied the benefits of, or be subjected to discrimination under any program or activity receiving Federal financial assistance.”) [5] Amitabh Chandra, Michael Frakes, and Anup Malani, “Challenges to Reducing Discrimination and Health Inequity Through Existing Civil Rights Laws,” Health Affairs (Project Hope) 36, no. 6 (June 1, 2017): 1041–47, 1042, https://doi.org/10.1377/hlthaff.2016.1091. [6] David Barton Smith, “The ‘Golden Rules’ for Eliminating Disparities: Title VI, Medicare, and the Implementation of the Affordable Care Act,” Health Matrix, 2015, Gale OneFile: LegalTrac. [7] Olatunde C. A. Johnson, “Lawyering That Has No Name: Title VI and the Meaning of Private Enforcement,” Stanford Law Review 66, 6 (June 2014): 1293-1331, at 1294. [8] Chandra, Frakes, and Malani, at 1043. [9] Alexander v. Sandoval, 532 U.S. 275 (2001). [10] Chandra, Frakes, and Malani, at 1043. [11] See 42 U.S.C. §2000d-1. [12] Chandra, Frakes, and Malani, at 1045. [13] 42 U.S.C. §18116. [14] Chandra, Frakes, and Malani, at 1045. [15] Sarah G. Steege, “Finding a Cure in the Courts: A Private Right of Action for Disparate Impact in Health Care,” Michigan Journal of Race & Law 16, 439 (April 2011): 439- 468. [16] See, e.g., Lemon v. Aurora Health Care North Inc., 19-CV-1384 (E.D. WI Feb. 22, 2021). [17] Johnson, “Lawyering That Has No Name,” at 1295. [18] Pub. L. No. 102-166, § 102, 105 Stat. 1071, 1072-72 (codified as amended at 42 U.S.C. § 1981a). [19] Sara Rosenbaum and Sara Schmucker, “Viewing Health Equity through a Legal Lens: Title VI of the 1964 Civil Rights Act,” Journal of Health Politics, Policy and Law 42, no. 5 (October 1, 2017): 771–88, 777, https://doi.org/10.1215/03616878-3940423. [20] Institute of Medicine (US) Committee On Understanding and Eliminating Racial and Ethnic Disparities in Health Care, Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care, ed. Brian D. Smedley, Adrienne Y. Stith, and Alan R. Nelson (Washington (DC): National Academies Press (US), 2003), http://www.ncbi.nlm.nih.gov/books/NBK220358/. [21] Chandra, Frakes, and Malani, at 1045. [22] National Federation of Independent Business v. Sebelius, 567 U.S. 519 (2012). [23] Harriet A. Washington et al., “Segregation, Civil Rights, and Health Disparities: The Legacy of African American Physicians and Organized Medicine, 1910-1968,” Journal of the National Medical Association 101, no. 6 (June 2009): 513–27, https://doi.org/10.1016/S0027-9684(15)30936-6.

Introduction The genealogy of Feminist Standpoint Theory in the 1970s prioritised “locationality”, particularly the recognition of social and historical locations as valuable contribution to knowledge production. Pioneering figures such as Sandra Harding, Dorothy Smith, Patricia Hill Collins, Alison Jaggar, and Donna Haraway have argued that the oppressed must have some means (such as language, cultural practices) to enter the world of the oppressor in order to access some understanding of how the world works from the privileged perspective. In the essay “Meeting at the Edge of Fear: Theory on a World Scale”, the Australian social scientist Raewyn Connell explains that the production of feminist theory almost always comes from the global North. Connell critiques the hegemony of mainstream Northern feminism in her pyramidal model (59), showing how theory/knowledge is produced at the apex (global North) of a pyramid structure and “trickles down” (59) to the global South. Connell refers to a second model called mosaic epistemology which shows that multiple feminist ideologies across global North/South are juxtaposed against each other like tiles, with each specific culture making its own claims to validity.However, Nigerian feminist Bibi Bakare-Yusuf’s reflection on the fluidity of culture in her essay “Fabricating Identities” (5) suggests that fixing knowledge as Northern and Southern—disparate, discrete, and rigidly structured tiles—is also problematic. Connell proposes a third model called solidarity-based epistemology which involves mutual learning and critiquing with a focus on solidarity across differences. However, this is impractical in implementation especially given that feminist nomenclature relies on problematic terms such as “international”, “global North/South”, “transnational”, and “planetary” to categorise difference, spatiality, and temporality, often creating more distance than reciprocal exchange. Geographical specificity can be too limiting, but we also need to acknowledge that it is geographical locationality which becomes disadvantageous to overcome racial, cultural, and gender biases — and here are few examples.Nomenclatures: Global-North and Global South ParadigmThe global North/South terminology differentiating the two regions according to means of trade and relative wealth emerged from the Brandt Report’s delineation of the North as wealthy and South as impoverished in 1980s. Initially, these terms were a welcome repudiation of the hierarchical nomenclature of “developed” and “developing” nations. Nevertheless, the categories of North and South are problematic because of increased socio-economic heterogeneity causing erasure of local specificities without reflecting microscopic conflicts among feminists within the global North and the global South. Some feminist terms such as “Third World feminism” (Narayan), “global feminism” (Morgan), or “local feminisms” (Basu) aim to centre women's movements originating outside the West or in the postcolonial context, other labels attempt to making feminism more inclusive or reflective of cross-border linkages. These include “transnational feminism” (Grewal and Kaplan) and “feminism without borders” (Mohanty). In the 1980s, Kimberlé Williams Crenshaw’s concept of intersectionality garnered attention in the US along with Gloria Anzaldúa’s Borderlands/La Frontera: The New Mestiza (1987), which raised feminists’ awareness of educational, healthcare, and financial disparities among women and the experiences of marginalised people across the globe, leading to an interrogation of the aims and purposes of mainstream feminism. In general, global North feminism refers to white middle class feminist movements further expanded by concerns about civil rights and contemporary queer theory while global South feminism focusses on decolonisation, economic justice, and disarmament. However, the history of colonialism demonstrates that this paradigm is inadequate because the oppression and marginalisation of Black, Indigenous, and Queer activists have been avoided purposely in the homogenous models of women’s oppression depicted by white radical and liberal feminists. A poignant example is from Audre Lorde’s personal account:I wheeled my two-year-old daughter in a shopping cart through a supermarket in Eastchester in 1967, and a little white girl riding past in her mother’s cart calls out excitedly, ‘oh look, Mommy, a baby maid!’ And your mother shushes you, but does not correct you, and so fifteen years later, at a conference on racism, you can still find that story humorous. But I hear your laughter is full of terror and disease. (Lorde)This exemplifies how the terminology global North/South is a problem because there are inequities within the North that are parallel to the division of power and resources between North and South. Additionally, Susan Friedman in Planetary Modernisms observes that although the terms “Global North” and “Global South” are “rhetorically spatial” they are “as geographically imprecise and ideologically weighted as East/West” because “Global North” signifies “modern global hegemony” and “Global South” signifies the “subaltern, … —a binary construction that continues to place the West at the controlling centre of the plot” (Friedman, 123).Focussing on research-activism debate among US feminists, Sondra Hale takes another tack, emphasising that feminism in the global South is more pragmatic than the theory-oriented feminist discourse of the North (Hale). Just as the research-scholarship binary implies myopic assumption that scholarship is a privileged activity, Hale’s observations reveal a reductive assumption in the global North and global South nomenclature that feminism at the margins is theoretically inadequate. In other words, recognising the “North” as the site of theoretical processing is a euphemism for Northern feminists’ intellectual supremacy and the inferiority of Southern feminist praxis. To wit, theories emanating from the South are often overlooked or rejected outright for not aligning with Eurocentric framings of knowledge production, thereby limiting the scope of feminist theories to those that originate in the North. For example, while discussing Indigenous women’s craft-autobiography, the standard feminist approach is to apply Susan Sontag’s theory of gender and photography to these artefacts even though it may not be applicable given the different cultural, social, and class contexts in which they are produced. Consequently, Moroccan feminist Fatima Mernissi’s Islamic methodology (Mernissi), the discourse of land rights, gender equality, kinship, and rituals found in Bina Agarwal’s A Field of One’s Own, Marcia Langton’s “Grandmothers’ Law”, and the reflection on military intervention are missing from Northern feminist theoretical discussions. Moreover, “outsiders within” feminist scholars fit into Western feminist canonical requirements by publishing their works in leading Western journals or seeking higher degrees from Western institutions. In the process, Northern feminists’ intellectual hegemony is normalised and regularised. An example of the wealth of the materials outside of mainstream Western feminist theories may be found in the work of Girindrasekhar Bose, a contemporary of Sigmund Freud, founder of the Indian Psychoanalytic Society and author of the book Concept of Repression (1921). Bose developed the “vagina envy theory” long before the neo-Freudian psychiatrist Karen Horney proposed it, but it is largely unknown in the West. Bose’s article “The Genesis and Adjustment of the Oedipus Wish” discarded Freud’s theory of castration and explained how in the Indian cultural context, men can cherish an unconscious desire to bear a child and to be castrated, implicitly overturning Freud’s correlative theory of “penis envy.” Indeed, the case of India shows that the birth of theory can be traced back to as early as eighth century when study of verbal ornamentation and literary semantics based on the notion of dbvani or suggestion, and the aesthetic theory of rasa or "sentiment" is developed. If theory means systematic reasoning and conceptualising the structure of thought, methods, and epistemology, it exists in all cultures but unfortunately non-Western theory is largely invisible in classroom courses.In the recent book Queer Activism in India, Naisargi Dev shows that the theory is rooted in activism. Similarly, in her essay “Seed and Earth”, Leela Dube reveals how Eastern theories are distorted as they are Westernised. For instance, the “Purusha-Prakriti” concept in Hinduism where Purusha stands for pure consciousness and Prakriti stands for the entire phenomenal world is almost universally misinterpreted in terms of Western binary oppositions as masculine consciousness and feminine creative principle which has led to disastrous consequences including the legitimisation of male control over female sexuality. Dube argues how heteropatriarchy has twisted the Purusha-Prakriti philosophy to frame the reproductive metaphor of the male seed germinating in the female field for the advantage of patrilineal agrarian economies and to influence a homology between reproductive metaphors and cultural and institutional sexism (Dube 22-24). Attempting to reverse such distortions, ecofeminist Vandana Shiva rejects dualistic and exploitative “contemporary Western views of nature” (37) and employs the original Prakriti-Purusha cosmology to construct feminist vision and environmental ethics. Shiva argues that unlike Cartesian binaries where nature or Prakriti is inert and passive, in Hindu Philosophy, Purusha and Prakriti are inseparable and inviolable (Shiva 37-39). She refers to Kalika Purana where it is explained how rivers and mountains have a dual nature. “A river is a form of water, yet is has a distinct body … . We cannot know, when looking at a lifeless shell, that it contains a living being. Similarly, within the apparently inanimate rivers and mountains there dwells a hidden consciousness. Rivers and mountains take the forms they wish” (38).Scholars on the periphery who never migrated to the North find it difficult to achieve international audiences unless they colonise themselves, steeping their work in concepts and methods recognised by Western institutions and mimicking the style and format that western feminist journals follow. The best remedy for this would be to interpret border relations and economic flow between countries and across time through the prism of gender and race, an idea similar to what Sarah Radcliffe, Nina Laurie and Robert Andolina have called the “transnationalization of gender” (160).Migration between Global North and Global SouthReformulation of feminist epistemology might reasonably begin with a focus on migration and gender politics because international and interregional migration have played a crucial role in the production of feminist theories. While some white mainstream feminists acknowledge the long history of feminist imperialism, they need to be more assertive in centralising non-Western theories, scholarship, and institutions in order to resist economic inequalities and racist, patriarchal global hierarchies of military and organisational power. But these possibilities are stymied by migrants’ “de-skilling”, which maintains unequal power dynamics: when migrants move from the global South to global North, many end up in jobs for which they are overqualified because of their cultural, educational, racial, or religious alterity.In the face of a global trend of movement from South to North in search of a “better life”, visual artist Naiza Khan chose to return to Pakistan after spending her childhood in Lebanon before being trained at the University of Oxford. Living in Karachi over twenty years, Khan travels globally, researching, delivering lectures, and holding exhibitions on her art work. Auj Khan’s essay “Peripheries of Thought and Practise in Naiza Khan’s Work” argues: “Khan seems to be going through a perpetual diaspora within an ownership of her hybridity, without having really left any of her abodes. This agitated space of modern hybrid existence is a rich and ripe ground for resolution and understanding. This multiple consciousness is an edge for anyone in that space, which could be effectively made use of to establish new ground”. Naiza Khan’s works embrace loss or nostalgia and a sense of choice and autonomy within the context of unrestricted liminal geographical boundaries.Early work such as “Chastity Belt,” “Heavenly Ornaments”, “Dream”, and “The Skin She Wears” deal with the female body though Khan resists the “feminist artist” category, essentially because of limited Western associations and on account of her paradoxical, diasporic subjectivity: of “the self and the non-self, the doable and the undoable and the anxiety of possibility and choice” (Khan Webpage). Instead, Khan theorises “gender” as “personal sexuality”. The symbolic elements in her work such as corsets, skirts, and slips, though apparently Western, are purposely destabilised as she engages in re-constructing the cartography of the body in search of personal space. In “The Wardrobe”, Khan establishes a path for expressing women’s power that Western feminism barely acknowledges. Responding to the 2007 Islamabad Lal Masjid siege by militants, Khan reveals the power of the burqa to protect Muslim men by disguising their gender and sexuality; women escape the Orientalist gaze. For Khan, home is where her art is—beyond the global North and South dichotomy.In another example of de-centring Western feminist theory, the Indian-British sitar player Anoushka Shankar, who identifies as a radical pro-feminist, in her recent musical album “Land of Gold” produces what Chilla Bulbeck calls “braiding at the borderlands”. As a humanitarian response to the trauma of displacement and the plight of refugees, Shankar focusses on women giving birth during migration and the trauma of being unable to provide stability and security to their children. Grounded in maternal humility, Shankar’s album, composed by artists of diverse background as Akram Khan, singer Alev Lenz, and poet Pavana Reddy, attempts to dissolve boundaries in the midst of chaos—the dislocation, vulnerability and uncertainty experienced by migrants. The album is “a bit of this, and a bit of that” (borrowing Salman Rushdie’s definition of migration in Satanic Verses), both in terms of musical genre and cultural identities, which evokes emotion and subjective fluidity. An encouraging example of truly transnational feminist ethics, Shankar’s album reveals the chasm between global North and global South represented in the tension of a nascent friendship between a white, Western little girl and a migrant refugee child. Unlike mainstream feminism, where migration is often sympathetically feminised and exotified—or, to paraphrase bell hooks, difference is commodified (hooks 373) — Shankar’s album simultaneously exhibits regional, national, and transnational elements. The album inhabits multiple borderlands through musical genres, literature and politics, orality and text, and ethnographic and intercultural encounters. The message is: “the body is a continent / But may your heart always remain the sea" (Shankar). The human rights advocate and lawyer Randa Abdel-Fattah, in her autobiographical novel Does My Head Look Big in This?, depicts herself as “colourful adjectives” (such as “darkies”, “towel-heads”, or the “salami eaters”), painful identities imposed on her for being a Muslim woman of colour. These ultimately empower her to embrace her identity as a Palestinian-Egyptian-Australian Muslim writer (Abdel-Fattah 359). In the process, Abdel-Fattah reveals how mainstream feminism participates in her marginalisation: “You’re constantly made to feel as you’re commenting as a Muslim, and somehow your views are a little bit inferior or you’re somehow a little bit more brainwashed” (Abdel-Fattah, interviewed in 2015).With her parental roots in the global South (Egyptian mother and Palestinian father), Abdel-Fattah was born and brought up in the global North, Australia (although geographically located in global South, Australia is categorised as global North for being above the world average GDP per capita) where she embraced her faith and religious identity apparently because of Islamophobia:I refuse to be an apologist, to minimise this appalling state of affairs… While I'm sick to death, as a Muslim woman, of the hypocrisy and nonsensical fatwas, I confess that I'm also tired of white women who think the answer is flashing a bit of breast so that those "poor," "infantilised" Muslim women can be "rescued" by the "enlightened" West - as if freedom was the sole preserve of secular feminists. (Abdel-Fattah, "Ending Oppression")Abdel-Fattah’s residency in the global North while advocating for justice and equality for Muslim women in both the global North and South is a classic example of the mutual dependency between the feminists in global North and global South, and the need to recognise and resist neoliberal policies applied in by the North to the South. In her novel, sixteen-year-old Amal Mohamed chooses to become a “full-time” hijab wearer in an elite school in Melbourne just after the 9/11 tragedy, the Bali bombings which killed 88 Australians, and the threat by Algerian-born Abdel Nacer Benbrika, who planned to attack popular places in Sydney and Melbourne. In such turmoil, Amal’s decision to wear the hijab amounts to more than resistance to Islamophobia: it is a passionate search for the true meaning of Islam, an attempt to embrace her hybridity as an Australian Muslim girl and above all a step towards seeking spiritual self-fulfilment. As the novel depicts Amal’s challenging journey amidst discouraging and painful, humiliating experiences, the socially constructed “bloody confusing identity hyphens” collapse (5). What remains is the beautiful veil that stands for Amal’s multi-valence subjectivity. The different shades of her hijab reflect different moods and multiple “selves” which are variously tentative, rebellious, romantic, argumentative, spiritual, and ambitious: “I am experiencing a new identity, a new expression of who I am on the inside” (25).In Griffith Review, Randa-Abdel Fattah strongly criticises the book Nine Parts of Desire by Geraldine Brooks, a Wall-Street Journal reporter who travelled from global North to the South to cover Muslim women in the Middle East. Recognising the liberal feminist’s desire to explore the Orient, Randa-Abdel calls the book an example of feminist Orientalism because of the author’s inability to understand the nuanced diversity in the Muslim world, Muslim women’s purposeful downplay of agency, and, most importantly, Brooks’s inevitable veil fetishism in her trip to Gaza and lack of interest in human rights violations of Palestinian women or their lack of access to education and health services. Though Brooks travelled from Australia to the Middle East, she failed to develop partnerships with the women she met and distanced herself from them. This underscores the veracity of Amal’s observation in Abdel Fattah’s novel: “It’s mainly the migrants in my life who have inspired me to understand what it means to be an Aussie” (340). It also suggests that the transnational feminist ethic lies not in the global North and global South paradigm but in the fluidity of migration between and among cultures rather than geographical boundaries and military borders. All this argues that across the imperial cartography of discrimination and oppression, women’s solidarity is only possible through intercultural and syncretistic negotiation that respects the individual and the community.ReferencesAbdel-Fattah, Randa. Does My Head Look Big in This? Sydney: Pan MacMillan Australia, 2005.———. “Ending Oppression in the Middle East: A Muslim Feminist Call to Arms.” ABC Religion and Ethics, 29 April 2013. <http://www.abc.net.au/religion/articles/2013/04/29/3747543.htm>.———. “On ‘Nine Parts Of Desire’, by Geraldine Brooks.” Griffith Review. <https://griffithreview.com/on-nine-parts-of-desire-by-geraldine-brooks/>.Agarwal, Bina. A Field of One’s Own: Gender and Land Rights in South Asia. 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